rbc
TRANSCRIPT
1Peripheral Blood
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Whole Blood
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Hemopoiesis
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ErythroidLineage
MyeloidLineage
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ErythropoiesisErythropoiesisFormation or making of red blood cellsFormation or making of red blood cells• Life-span 120 daysLife-span 120 days• New-born = old-death = 1 - 1.5 %New-born = old-death = 1 - 1.5 %• Bone marrow ==> macrophages (RE cells)Bone marrow ==> macrophages (RE cells)• Fe, Proteins (amino acids),Fe, Proteins (amino acids), B12, Folate, etc. B12, Folate, etc.
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Erythron
Erythropoiesis
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Blood Forming OrgansBlood Forming Organs• Mesoblastic periodMesoblastic period
yolk sacyolk sac• Hepatic periodHepatic period
liver & spleenliver & spleen• Myeloid periodMyeloid period
bone marrow (BM)bone marrow (BM)
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Blood Forming Organs Blood Forming Organs (cont.)(cont.)
• Medullary HemopoiesisMedullary Hemopoiesisbone marrow (BM)bone marrow (BM)
• Extramedullary HemopoiesisExtramedullary Hemopoiesisliver / spleenliver / spleen
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Blood FormingOrgans
10Stages of Erythron
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E2E1
E3E
4E5
E3
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Extrusion Polychromasia
Reticulocytes Erythrocytes
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ErythropoiesiErythropoiesis Mechanisms Mechanism• ProliferationProliferation
• DifferentiationDifferentiation• MaturationMaturation• ReleaseRelease• Functional RBCFunctional RBC• Senile RBCSenile RBC
15Erythropoiesis MechanismErythropoiesis Mechanism
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Characteristic of ErythronCharacteristic of Erythron
17Bone Marrow StructureBone Marrow Structure
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Bone Marrow SectionBone Marrow Section
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Bone MarrowBone MarrowContourContour
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Normal Red Blood Cells
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Functional Blood Cells
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Regulation of ErythropoiesisRegulation of Erythropoiesis• HypoxiaHypoxia• Oxygen tension in bloodOxygen tension in blood• Peritubular cells in Peritubular cells in KidneyKidney• ErythropoietinErythropoietin• Nutrients & raw materialsNutrients & raw materials
23Regulation of ErythropoiesisRegulation of Erythropoiesis
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Erythropoietin (Epo)Erythropoietin (Epo)•Chromosome 7 (q)Chromosome 7 (q)•3000 kDa3000 kDa•165 Amino acids165 Amino acids•60 % Proteins60 % Proteins•40 % Carbohydrate40 % Carbohydrate•Peritubular cells in Peritubular cells in KidneyKidney
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Molecule of ErythropoietinMolecule of Erythropoietin
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Factors Effecting ErythropoiesisFactors Effecting Erythropoiesis
• Micro-environmentMicro-environment• Stem cellsStem cells• Nutrients / Erythropoietin / Etc.Nutrients / Erythropoietin / Etc.