re-engineering of research and graduate studies @ usf...

Research and Innovation to Improve Health

Re-engineering of Research and Graduate Studies @ USF Health

Presented to:

USF BOT/Health Sciences & Research WorkgroupWednesday, February 15, 2006

Abdul S. Rao, MD, MA, DPhil

Office of Research and Graduate Affairs


Extramural Funding - USF

290

255

287

179 179

160

0

50

100

150

200

250

300

350

FY 02-03 FY 03-04 Fy 04-05

Fiscal Years

Total Research Training Other


Extramural Funding - USF Health

134

120

145

113 117

88

29 2519

1.72.72.6

0

20

40

60

80

100

120

140

160

FY 02-03 FY 03-04 Fy 04-05

Fiscal Years

Total COM COPH CON

8%

3.4%

24%

37%


Sources of Extramural Funding - COM

117

88

113

29 2734

15 15 13

44

7566

0

20

40

60

80

100

120

140

FY 02-03 FY 03-04 Fy 04-05

Fiscal Years

Total NIH Clinical Trials Other

COM


Clinical Trial Activity - COM*

10.8

15.8

11.4

44.2

5.2

0.0

2.0

4.0

6.0

8.0

10.0

12.0

14.0

16.0

18.0

FY 02-03 FY 03-04 Fy 04-05

Fiscal Years

Awards Expenditure

~75%

~61%~45.6%

COM *Excludes DIO clinical research activity


What is the indirect cost recovery rate for USF Health?


Sources of Extramural Funding – USF HealthIndirect Cost Recovery Rates*

21.04,193,80719,996,324Engineering

9.82,587,84626,397,862FMHI

20.83,277,89515,782,345Arts & Sciences

19.53,675,62618,810,894Public Health

19.5349,6521,653,229Nursing

6.26,760,396108,954,934Medicine

% RECOVERYRECOVERED INDIRECTSEXPENSES

COLLEGE/AREA

* As reported by USF Office of Research Award Data: September 12, 2005


Sources of Extramural Funding – USF COMIndirect Cost Recovery Rates

5.79375,9876,496,230Clinical Trials

7.27,383,020103,196,217Medicine (COM)

60,263,732TOTAL:

17.27,383,02042,932,485TOTAL:

12.58525,7014,178,051Private Contracts & Grants

9.67522,4725,402,481State Contracts & Grants

Without Indirects

14,253,280MCC Salary Support

21,552,758UMSA Salary SupportN/A

24,457,694GME - House staff

22.195,958,86026,855,723Federal Grants & Contracts

With Indirects

6.26,760,396108,954,934Medicine (OR)


COLLEGE/AREA


Sources of Extramural Funding – USF HealthIndirect Cost Recovery Rates

2.11,76284,674Other (VP/Dean)22.1332,5741,506,013CON18.73,970,56121,204,144COPH17.27,383,02042,932,485COM

17.811,687,91765,727,316TOTAL:


COLLEGE/AREA


What is the level of utilization of services offered by the USF

Office of Research by the faculty, staff, and students of

USF Health?


Services Provided by USF Office of Research and Percent Usage by USF Health

Animal Research Protocols

Human Research Protocols

Award AmountFY 04-05

# of Awards and Contracts

FY 04-05

Animal census December 2005

Billing

COMMENTS

39.9%4431109Division of Research Integrity &

Compliance*

46.6%$134 million$287 million

38.1%6811789Division of Sponsored Research

33.8%6,45419,103Comparative Medicine

75.0%186248

USF HEALTH % OF TOTAL

USF HEALTH TOTALUSF TOTAL

SERVICEAREA

*July 01 - July 31, 2005


Why do universities invest disproportionately more in

enhancing research capacity in health (life) sciences?


Health Sciences Contribution to Federal Research Expenditures (2002)*

67.984,108Univ. of South Florida77

71.8142,625Univ. of Utah50

71.8143,183Univ. of Illinois, Chicago49

67.3167,108Univ. of Florida41

69.5487,059Univ. of Washington, Seattle2

% Life Sciences

Expenditures($; millions)

UniversityRanking

*The Top American Research Universities; December 2004; The Center Report


Strategic Objectives – USF Health

• Support the accomplishment of USF’s strategic goals• Develop and implement an objective “roadmap” for

strategic growth in research and graduate affairs• Double our total research expenditures from $65 million

in FY04-05 to $130 million by FY10-11• Continue to improve NIH peer-ranking of COM, CON,

and COPH• Enhance clinical and translational research• Enhance interdisciplinary research collaborations

between faculty, staff, and students at USF, USF Health, and affiliate partners

• Identify new resources of funding to support projected growth in research capacity


Strategic ObjectivesUSF Health - COM

• Identify signature programs of strategic research interest

• Reorganize basic science research – Establish a School of Biomedical Sciences

• Double total research expenditures from $43 million in FY04-05 to $86 million by FY10-11

• Establish an Office of Clinical Research• Increase clinical research expenditures from $5.2 million in

FY04-05 to $12 million by FY10-11• Among AAMC-accredited medical schools, to

be in the 50th percentile in NIH ranking

COM


By 2010:

• Advance into the top third of schools of public health in total direct expenditures from grants and contracts ($26 million)

• Quadruple NIH awards from $0.3 million in FY04-05 to $1.2 million

• Double other federal awards from $14.4 million in FY 04-05 to $29 million

• Double private foundation awards from $0.9 million in FY04-05 to $1.8 million

COPH

Strategic ObjectivesUSF Health - COPH


BY 2010:

• In NIH ranking, make CON one of the top 20 nursing schools in the U.S.

• Increase total awards from ~$1.7 million in FY04-05 to ~$6 million

CON

Strategic ObjectivesUSF Health - CON


Challenges - I

• Leveling or decline in available NIH and other Federal and State funding

• Lack of an executable strategic plan• Inadequate number of research-intensive

faculty• Competing demands on finite resources• Inadequate and/or low quality research space• Inadequate number of graduate students -

COM


Challenges – II

• Lack of a post-doctoral training program• Quality and outcome measurements are

not clearly outlined – poor definition of expectations and consequences

• Limited financial resources• Inadequate (non-existent) CORE facilities• Relatively small number of investigators

involved in translational research• Relatively limited multidisciplinary and

interdisciplinary team-based research


What are we doing to overcome these challenges?

College of Medicine


Rules for Selection of Signature Programs of Strategic Research Interest

• Takes advantage of our existing intellectual, academic, and clinical strengths

• Aligned with local, regional, and national needs and priorities

• Has a long-term (> five years) prospect of sustained extramural funding

• Has prospect for a substantial level of funding (≥$5 million per year)

• Is interdisciplinary in scope• Takes advantage of our doctoral programs


Signature Programs of Strategic Research Interests

Primary Areas:• Neurosciences• Cardiovascular• Emerging Infectious Diseases and Immunology

Emerging/Supporting Technologies:• Genomics and Proteomics• Bioinformatics/Computational Biology• Pharmacogenomics• Drug Discovery and Development• Structural Biology• Biomedical Engineering• Regenerative and Nano Medicine• Orthotics and Prosthetics


Signature Research Programs

NEU

RO

SCIE

NC

ES

CA

RD

IOVA

SCU

LAR

INFE

CTI

OU

S D

ISEA

SES/

IMM

UN

OLO

GY

• Emerging/Supporting Technologies• Core Facilities

Faculty, staff and students

from:• Departments

• Centers• Institutes• Colleges• Schools

at

• USF• USF Health

• Affiliate Partners


Signature Programs of Strategic Research Interests - I

• Established outside the departmental, center, institute, and collegiate boundaries

• Each program will be co-directed by two individuals; a clinical and a basic researcher

• Will promote horizontal (interdisciplinary) and vertical (translational) integration of research and researchers


Signature Programs of Strategic Research Interests - II

• Enhancement of research capacity in these programs will be accomplished by:– Targeted recruitment of ALL basic science faculty– Whenever possible, targeted recruitment of Endowed

Chairs– Continued development of clinical services in these

areas – setting the “standard of care” in these signature programs

– Creation of specialized CORE facilities– Competitive “seed funding”– Development of a concept of program-specific

“community of scholars” facilitated by social synergy events, journal clubs, lecture series, local and regional research conferences, etc.

– Realignment of biomedical graduate programs


RESEARCH EXPENDITURE GROWTH PLAN – College of Medicine

FY 2005 - 2010

COM

GOAL• In the next five years, to increase our research

expenditures from$43 million (FY04) → $86 million (FY10)

Target: $43 million by FY10-11

• Same Store Growth (25%): $10.75 million• New Faculty Recruitment (60%): $25.80 million• Synergy & Collaboration (15%): $06.45 million


Projected Cost of Enhancement of Research Expenditure - COM

1,500,000250,000250,000250,000250,000250,000250,000Other

Infrastructure Upgrade

8,000,0002,000,0002,000,00002,000,0002,000,0000Chair

33,900,0005,800,0006,950,0004,850,0006,750,0006,650,0002,900,000Total Yearly Cost ($):

500,000

2,750,000(n=11)

300,000

YEAR 05(10-11)

8,500,0001,900,0001,800,0001,700,0001,600,0001,000,000Core Facilities**

14,250,000(n=57)

2,500,000(n=10)

2,500,000(n=10)

2,500,000(n=10)

2,500,000(n=10)

1,500,000(n=6)

New Faculty Recruitment*

1,650,000300,000300,000300,000300,000150,000Same Store Growth

Cumulative Cost ($)

YEAR 04(09-10)

YEAR 03(08-09)

YEAR 02(07-08)

YEAR 01(06-07)

YEAR 00(05-06)

AREA

*Each new faculty costs ~$250K with ~$450K/year in research expenditures; 57 new faculty to be recruited in the next 5.5 years**Five facilities at ~$1.5 million/facility capital cost and $100K recurring operations cost/facility; one core facility to be established/year


Projected Cost of Enhancement of Research Expenditure - COM

Total Estimated Cost: ~$34 million

Important Considerations:• It is only an estimate• Does not include the cost of improving existing and/or

construction of new space• Requires modest increase in research productivity of

existing faculty• Requires relatively higher level of synergy and

collaboration• Does not include the cost of improving graduate

programs• Cost of recruitment of faculty is highly variable• All faculty recruited in this period will be extramurally

funded


What else do we have to do to enhance our basic research capacity?

• Continue to improve the quality of our biomedical graduate programs – COM

• Develop and adequately maintain KEY CORE facilities

• Build a new Interdisciplinary Biomedical Science Building

• When?: by 2008-09• How large?: ~100 - 125K ft2 (net)


Integrated Biomedical Graduate Program

Enro

lled

Gra

duat

e St

uden

ts

Com

mon

Inte

rdis

cipl

inar

y C

urric

ulum

Neurosciences

Infectious Diseases

Cardiovascular

Oncology

Bioengineering

Regenerative & Nano Medicine

Other

Areas of Research EmphasisCOM


External Review of Biomedical Graduate Programs

• External Reviewers• Dr. Alan Yates, Director of Integrated Biomedical

Graduate Program, Ohio State University, College of Medicine

• Dr. Roger Chalkley, Sr. Associate Dean, Biomedical Research Education & Training, Vanderbilt University

• Timeline:• On-campus visit February 28 - March 01, 2006• Report due date: March 24, 2006

COM


Develop CORE FacilitiesWhat CORE Facilities do we need?

• Microscopy and Imaging• Flow Cytometry and Cell Sorting• Genetics and Microarray• Bioinformatics/Computational

Sciences• Pharmacogenomics• Proteomics• Others


Interdisciplinary Research Facility*

1. USF Utilities Infrastructure2. Visual & Performing Arts Teaching

Facility3. Interdisciplinary Science Teaching &

Research Facility (~109K net ft2)4. Honors College Classroom/Support

Services5. HSC Research Building II (~160K net ft2)

*PECO List Period 2006 - 2011


Increase Financial Resources


Potential Sources of Support for Sustaining and Enhancing Research Mission in

Comprehensive Universities

• Reinvestment of indirects (Rebate Funds)• University and State support• Federal appropriations• Endowments• Gifts and philanthropy• Technology transfer and commercialization• Reallocation of funds in:

– Educational mission– Clinical practice, others

• Support from “affiliate” partners


Initiate a Nation-wide Campaign

CREATE

Campaign for Research Enhancement & Academic & Teaching Excellence


Goals of CREATE

• Improve human health through cutting-edge research and innovation - setting the “standard of care”

• Continue to improve the economy of the region and the State

• Enhance the academic stature of USF and USF Health among its current and inspirational peers

• Create enhanced opportunities for public-private partnerships

• Develop a technically skilled workforce for evolving local, regional, national, and international needs


Objectives of CREATE

• Raise $200 million by 2010• Build upon existing strengths in:

– Neurosciences - “Brain Health”– Cardiovascular - “Heart Health”– Infectious Diseases/Immunology “Immune Health”

• Support enhancement of research and education in interdisciplinary biomedical sciences by:– Recruitment of new faculty– Improvement of graduate programs– Construction of a new 150,000 ft2 interdisciplinary research

facility– Establishment of state-of-the-art CORE facilities


February 15, 2006

USF AND USF HEALTH LAUNCH A MAJOR CAMPAIGN TO ENHANCERESEARCH AND EDUCATIONBy: Gil Thelen

President Judy Genshaft, Vice President Steve Klasko, and members of the Board of Trustees of theUniversity of South Florida unveiled a five year $200 million blueprint to enhance innovative research and education to improve health, continue to improve the economy of the region, and enhance the academic stature of the University.

This campaign entitled “CREATE; Campaign for Research Enhancement and Academic andResearch Excellence”, embraces President Genshaft’s vision to move USF in the elite group of the top 50 public research universities in the country. “This is the scale of thinking and initiative that has to be implemented if you want to be a leader,” said Rhea Law, a member of the USF Board of Trustees and Chair of the Health Sciences and Research Workgroup.

A Reverie….

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