reabsorb : an absorbable stent
DESCRIPTION
TRANSCRIPT
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REabSORB : A STENT THAT DISAPPEARS
IDEA GENERATED & PRESENTED BY :MINAL CHAUHAN - 7MALVIKA BANSAL - 11SHILPA TAHAKAR - 14
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JOURNEY
1) INTRODUCTION2) CURRENT SITUATION3) MARKET STUDY4) PRE LAUNCH SURVEY5) NEW PRODUCT DEVELOPMENT6) POST LAUNCH STRATEGY7) BENEFITS8) EXPECTED OUTCOME9) SUPPLEMENTARY SLIDES
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JOURNEY
1) INTRODUCTION2) CURRENT SITUATION3) MARKET STUDY4) PRE LAUNCH SURVEY5) NEW PRODUCT DEVELOPMENT6) POST LAUNCH STRATEGY7) BENEFITS8) EXPECTED OUTCOME9) SUPPLEMENTARY SLIDES
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Commonest cause of coronary artery blockage
Results in a fixed blockage
May be accompanied by coronary spasm
ATHEROSCLEROSIS
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CYCLE
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A mesh 'tube'
Inserted into a natural passage/conduit in the body
Treats narrow or weak arteries
STENT
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Stents usually are made of metal mesh, but
sometimes they're made of fabric
Fabric stents, also called stent grafts, are used in
larger arteries
Some stents are coated with medicine that is slowly
and continuously released into the artery
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Figure A shows the location of the heart and coronary arteries
Figure B shows the deflated balloon catheter and closed stent inserted into the narrow coronary artery
The inset image shows a cross-section of the artery with the inserted balloon catheter and closed stent
In figure C, the balloon is inflated, expanding the stent and compressing the plaque against the artery wall
Figure D shows the stent-widened artery. The inset image shows a cross-section of the compressed plaque and stent-widened artery
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Risks Related to Stents
Blood clot at the stent site
Blood clots can cause a heart attack, stroke, or other
serious problems
Stents coated with medicine may raise the risk of
dangerous blood clots
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JOURNEY
1) INTRODUCTION2) CURRENT SITUATION3) MARKET STUDY4) PRE LAUNCH SURVEY5) NEW PRODUCT DEVELOPMENT6) POST LAUNCH STRATEGY7) BENEFITS8) EXPECTED OUTCOME9) SUPPLEMENTARY SLIDES
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STRAIN TAKES TOLL ON HEART
Hypertension : three times higher in urban citizens
than their rural counterparts
9% of population in the age bracket of 40-70 undergo
angioplasty every year
BMS is the most popular choice
Several post surgery complications are involved
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JOURNEY
1) INTRODUCTION2) CURRENT SITUATION3) MARKET STUDY4) PRE LAUNCH SURVEY5) NEW PRODUCT DEVELOPMENT6) POST LAUNCH STRATEGY7) BENEFITS8) EXPECTED OUTCOME9) SUPPLEMENTARY SLIDES
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JOURNEY
1) INTRODUCTION2) CURRENT SITUATION3) MARKET STUDY4) PRE LAUNCH SURVEY5) NEW PRODUCT DEVELOPMENT6) POST LAUNCH STRATEGY7) BENEFITS8) EXPECTED OUTCOME9) SUPPLEMENTARY SLIDES
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STRATEGIES
Meeting doctors
Understanding consumer requirements
Analyzing current problems
Conducting survey through questionnaires
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Which is the most commonly used STENT ?
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Which kind of STENT is a better option?
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JOURNEY
1) INTRODUCTION2) CURRENT SITUATION3) MARKET STUDY4) PRE LAUNCH SURVEY5) NEW PRODUCT DEVELOPMENT6) POST LAUNCH STRATEGY7) BENEFITS8) EXPECTED OUTCOME9) SUPPLEMENTARY SLIDES
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Circumferential PLLA hoops
150 µm thick
Hoops directly joined by bridges
BASIC DESIGN
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PLLA (Poly-L-Lactic Acid) Backbone
PDLLA (Poly-D, L-Lactic Acid) Coating
Drugs coated on it include :
VEGF (Vascular Endothelial Growth Factor) to
promote healing
ASPIRIN to reduce the ability of blood to clot
easily
STATIN to help in reabsorbing cholesterol
COMPONENTS
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Both the backbone and coating will degrade to
lactic acid (Kreb’s cycle)
Drugs coated on it are to serve their respective
function
Entire stent should dissolve in 2-3 yrs without
any side effects
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JOURNEY
1) INTRODUCTION2) CURRENT SITUATION3) MARKET STUDY4) PRE LAUNCH SURVEY5) NEW PRODUCT DEVELOPMENT6) POST LAUNCH STRATEGY7) BENEFITS8) EXPECTED OUTCOME9) SUPPLEMENTARY SLIDES
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Strategies
Spreading awareness
Contacting doctors & MRs
One on one presentations
Hiring professionals for personal selling
Taking feedback
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JOURNEY
1) INTRODUCTION2) CURRENT SITUATION3) MARKET STUDY4) PRE LAUNCH SURVEY5) NEW PRODUCT DEVELOPMENT6) POST LAUNCH STRATEGY7) BENEFITS8) EXPECTED OUTCOME9) SUPPLEMENTARY SLIDES
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Polymers are biocompatible
100% drug elution in 4 months
Complete healing of endothelium possible
No corrosion or dislocation
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JOURNEY
1) INTRODUCTION2) CURRENT SITUATION3) MARKET STUDY4) PRE LAUNCH SURVEY5) NEW PRODUCT DEVELOPMENT6) POST LAUNCH STRATEGY7) BENEFITS8) EXPECTED OUTCOME9) SUPPLEMENTARY SLIDES
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Reduced stent thrombosis
Reduction in therapy time
Limited chances of re-placement requirement
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JOURNEY
1) INTRODUCTION2) CURRENT SITUATION3) MARKET STUDY4) PRE LAUNCH SURVEY5) NEW PRODUCT DEVELOPMENT6) POST LAUNCH STRATEGY7) BENEFITS8) EXPECTED OUTCOME9) SUPPLEMENTARY SLIDES
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Pre-supposed approval by FDA
Rs. 90,000 : average cost of a stent in India
Based on historical precedence, our price 2.5 lakh at
initial entry
20% hurdle rate
Total cost inclusive of trials : 8 crores
Profit Margin of 65%
ASSUMPTIONS
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TRIAL BUDGET BREAKDOWNTRIAL REQUIREMENTS COST INCURRED*
(Rs.)FOLLOW UP, 5 YRS, 50
PATIENTS 1,00,000 * 5 * 50 =
2,50,00,000 ANGIOGRAPHY, 50
PATIENTS 20,000 * 2 * 50 =
20,00,000 RESOURCE COST, 50
PATIENTS 60,000 * 50 =
30,00,000 MEDICAL COST, 50
PATIENTS 10,000 * 5 * 50 =
25,00,000 IVUs COST, 50
PATIENTS 50,000 * 50 =
25,00,000MISCELLANEOUS COSTS 2,00,000
TOTAL TRIAL COST 3,52,00,000* ALL FIGURES ARE IN APPROXIMATION
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http://blog.mediligence.com/2007/05/12/drug-eluting-stents-2/
http://www.bioabsorbabletx.com
http://www.vascularconcepts.com
http://www.revespcardiol.org/en/influencia-trombosis-del-stent-relacion/articulo/13150746/
http://www.cxvascular.com
http://www.nbcnews.com
http://www.nhlbi.nih.gov
http://www.news-medical.net/health/Stent-Types.aspx
REFERENCES
http://www.abbottvascular.com
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