recognizing ultrasound patterns in the assessment of thyroid
TRANSCRIPT
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Neck Ultrasound Pattern Recognition in the
Evaluation of Thyroid NodulesMark A Lupo, MD, FACE, ECNU
Thyroid & Endocrine Center of Florida
Sarasota, Florida
Assistant Clinical Professor, Florida State University College of Medicine
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Low Risk Ultrasound Features of Nodules
• Colloid nodules (cat’s eye, comet tail artifact)
• Spongiform nodules
• Simple cysts
• Isoechoic/Hyperechoic• Especially a hyperechoic nodule with background Hashimoto’s (“white
knight”)
• Thin, regular halo
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Thin-walled Cyst
Enhancement
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Comet Tails
• Reverberation artifact from vibrating desiccated colloid
• Most common in cystic or partially cystic nodules
• Best appreciated in real-time as can be confused with microcalcifications
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Colloid Within Nodule “Cat’s Eye” (Comet
Tail, Stepladder or Ringdown artifact)
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• aggregation of multiple microcystic components in more than 50% of the volume of the nodule
• “honeycomb of internal cystic spaces”
• Only 1 in 360 spongiform nodules malignant
• 99.7% Specificity (Moon)
“Spongiform” nodules
Moon Radiology 2008; 247: 762-70Bonavita AJR 2009; 193:207-13
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Spongiform echotextureSPONGIFORM NODULES
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Spongiform Echotexture
Note: Bright Linear Reflectors all
posterior to the microcystic areas
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Halos & Margins
• Halo: sonolucent rim around an iso/hyperechoic nodule representing capsule
• Thin/regular – lower risk• Thick/irregular – higher risk
Hypoechoic Nodules ---- Margins:• Smooth and regular
• Poorly Defined: interface between nodule and surrounding parenchyma is difficult to delineate
• Lower risk, seen in hyperplastic nodules
• Irregular: the demarcation between the nodule and parenchyma is clearly visible but demonstrates and irregular, infiltrative or spiculated course.
• Higher risk
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Halo
Edge Artifact
Halo
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Hypoechoic NodulesNo Halo, but a Smooth Margin
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Halo irregular
Follicular adenoma
Yokozawa T
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Halo
Thin Halo
Benign Follicular AdenomaThick, Irregular Halo
Follicular CA
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Margins
Poorly defined, but notinfiltrative (spongiform)Irregular
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Suspicious Ultrasound Features of Nodules
• Markedly hypoechoic
• Invasive, infiltrative margins
• Microcalcifications
• Taller than wide shape (AP>TRV in transverse view)
• Abnormal cervical lymph nodes
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Markedly Hypoechoic
Compare to strap muscles and SCM
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Calcifications: Pattern recognition• Microcalcifications • Coarse Calcification
• Colloid “Ring-down” Reverberation Artifact
• Posterior Acoustic Enhancement Artifact
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PTC with Microcalcifications
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Microcalcifications vs Comet Tails
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sagittal
NOT microcalcifications!
sagittal
???
Small hyperechoic linear streaks just posterior to small cystic area posterior acoustic enhancement!
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Ultrasonographic appearance of
Follicular Variant Papillary
Isoechoic, variable thickness halo
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Sonographic Features of Follicular Variant Papillary Cancer versus Conventional Papillary Cancer
FEATURE FOLLICULAR
VARIANT (n=44)
CONVENTIONAL
PAPILLARY (n=74)
Size (mean) 17 mm 10.5 mm
Ovoid to round shape 95% 73%
Isoechoic 52% 8%
Halo 25% 3%
Taller than Wide 5% 22%
Marked Hypoechogenicity 5% 38%
Microcalcifications 3% 24%
FNAB Dx of Papillary CA 28% 56%
FNAB Indeterminate 46% 19%
Kim DS et al. J Ultrasound Med 2009, 28:1685
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Sonographic features:Papillary vs. Follicular Variant of PTC
0
20
40
60
80
100F
req
uen
cy (
%)
Hypoechoic Halo Spiculated
margins
Smooth
margins
MicroCa2+
Classic PTC
FV PTC
Kim J Ultrasound Med 2009
*
*
*
**
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Follicular variant of PTC
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PTC foll variantBenign Hürthle cell adenoma
Follicular thyroid cancer
Isoechoic/Hyperechoic and Solid
~20% of all cancers are Iso/hyperechoic: predominantly follicular/ Hürthle
Hyperplastic noduleHyperplastic nodule
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Taller than wide
Kim AJR 2002; Cappelli Clin Endocrinol 2005; Moon Radiology 2008
Nodule is taller than wide on
the transverse view
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Infiltrative/Irregular Borders
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Invasion of strap muscleMicrocalcificationsHypoechoic
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Invasion of Carotid Sheath
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Cystic PTC
Microcalcifications
Irregular, eccentric solid component
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Cystic change
• 360 thyroid cancers at Mayo Clinic:
Solid or minimally (5%) cystic: 88%
<50% cystic: 9%
>50% cystic: 3% and another suspicious sonographicfeature present1
Cystic papillary cancer1Henrichsen et al, RSNA 2005
Comet tail reverberation artifact
microcalcifications
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What About Intranodular Flow?
B-Mode Power Doppler
NO LONGER CONSIDERED AN INDEPENDENT
RISK FACTOR WHEN DECIDING ON FNA
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Vascularity - What to do?
• Consider whether features are suspicious for papillary or follicular cancers.
• Hypoechoic or features of papillary:
• Vascularity may be less important• Iso or hyperechoic with variable thickness halo:
• Consider intranodular vascularity as potential risk.
• AACE 2010 guidelines do consider vascularity.
• Korean 2011 and ATA 2015 guidelines do not consider vascularity
• **Don’t be reassured by absence of vascularity.**
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Rounded &
Infiltrative
NORMAL ABNORMAL
Hilum – with vascular flow
Calcifications
Peripheral Vascularity
LYMPH NODES
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Suspicious Lymph Node Features
• Rounded Shape
• Peripheral/Chaotic Vascularity
• Loss of hilar line
• Jugular Compression
Suspicious features not seen here
• Calcification
• Cystic change
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Longitudinal View of Right level IV Node
• Chaotic/pericpheral vascularity
• Jugular compression
• Loss of hilar line
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Malignant Node
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LEFT Nodule -- PTCLEFT Lateral Neck: Abnl LNs
Image from: Sheth, S: Role of Ultrasonography in Thyroid Disease. Otolaryngol Clin N Am 43 (2010) 239–255
US of Thyroid only….. US of Entire Neck reveals…..
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Differential Diagnosis for Lymph Nodes
• Reactive lymphadenopathy (recent URI, dental work, AITD, etc)
• Metastasis – thyroid, head/neck SCCA, breast, lung, melanoma
• Sarcoidosis
• Lymphoma
• CLL
• Infectious granulomatous disease
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Ultrasound Patterns in Autoimmune Thyroid Disease
• Heterogeneous echotexture
• Hashimoto’s typically hypoechoic, but can be hyperechoic
• Pseudonodularity• Small multiple hypoechoic psuedomicronodules (“lakes of lymphocytes”)• Banding fibrosis creating pseudomicronodular appearance
• Giraffe pattern – hyperechoic globular pattern (w/ hypoechoic borders)
• White knight – regenerative hyperechoic nodules
• Reactive cervical lymph nodes
• Isthmus AP thickened (>5mm)
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Autoimmune Thyroid Disease
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Normal vs Hashimoto’s
Side-by-side virtual panoramic transverse views
Left panel demonstrates normal homogeneous echotexture
Right panel shows heterogeneity, fibrosis and hypoechogenicity typical of
Hashimoto’s thyroiditis.
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Pseudomicronodules
Small hypoechoic areas < 1cm represent lymphocyte infiltration and
pseudomicronodules.
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Pseudomicronodules
“Swiss Cheese” In this pattern the pseudonodules are
more well defined and slightly larger. This is commonly misinterpreted
as a multinodular goiter
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Drug Induced Thyroiditis
This patient with metastatic melanoma was initially seen for an incidentally
discovered right nodule which was benign. The left panel shows the normal left lobe
at initial evaluation. Subsequently she was treated with Ipilimumab and developed
thyroiditis after four months with typical sonographic changes of heterogeneity,
fibrosis, and hypoechogeniticy.
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Hyperechoic Nodule
Bonavita AJR 2009; 193:207-13
With background Hashimoto’s WHITE KNIGHT
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Hyperechoic with background of Hashi’s
Nodule
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Giraffe Pattern
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Cleft Sign (aka Mitten Sign)
Right Transverse Right Sagittal
Thick hyperechoic fibrotic band separates the posterior and
anterior components of the lobe in transverse view creating the appearance
of a hypoechoic nodule (arrow) with hyperechoic halo
(note: true halos are only hypoechoic)
In Sagittal view, it is evident that there is no discrete nodule.
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Cleft Sign
In transverse view, there appears to be a hypoechoic nodule in the posterior
aspect of the right lobe (arrow). In sagittal view, it becomes clear that a band of fibrosis
created the appearance of a nodule (thin arrow)
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Cleft sign w/ Tubercle of Zuckerkandl
Figure 22. The left panel shows a transverse view giving the appearance of a nodule
In the posterior right lobe. The right panel sagittal view confirms this to be hyperechoic
banding fibrosis, in this case with an extension at the inferior posterior aspect
of the lobe representing a tubercle of Zuckerkandl (arrow) which frequently creates a more
prominent cleft sign.
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Tubercle of
Zuckerkandl
Superior
Parathyroid Gland
Tubercle of Zuckerkandl
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Multiplicity
Multiple blocks of hyperechogenicity
separated by bands of hypoechogenicity
with low probability of malignancy
“Giraffe pattern” Bonavita AJR 2009
Multiple coalescing nodules with little/no normal intervening parenchyma
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Multinodular Goiter
Enlarged thyroid with multiple
sonographically similar nodules with
little or no normal intervening parenchyma
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Multinodular Goiter:Characteristics matter more than Size
A patient with multinodular thyroid has a similar risk of
malignancy as a patient with a single thyroid nodule.
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Multiplicity
Multiple discreet nodules need to be
evaluated individually.
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Parathyroid
• Hypoechoic• Polar feeding vessel• Shape conforms to thyroid• Often posterior-medial to CCA
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Parathyroid Adenoma
PA
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Transverse Cervical Spine Process
• Calcified “spike” in lateral neck
• Posterior shadowing
• Often indents SCM
• More frequently seen in women with thin necks
• Don’t confuse with a calcified lymph node
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Sonographic MimicsZenker
Kobaly K, Mandel S, Langer J. JCEM Feb 2015, 371-375.
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ATA 2015 Guidelines
Nodule Evaluation is Based on RISK STRATIFICATION of PATTEN
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HighSuspicion70-90%
IntermediateSuspicion10-20%
LowSuspicion
5-10%
Very lowSuspicion
<3%
Benign<1%
ATA 2015: Nodule Sonographic Pattern Risk of Malignancy
Haugen et al.; Thyroid, January 2016
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HIGH Suspicion Pattern 70-90%
irregular margins, suspicious left lateral lymph nodehypoechoic, interrupted rim
calcification with soft tissue extrusion
hypoechoic, irreg margin, extrathyroidal extension
hypoechoic, irreg margin, taller than wide
hypoechoic, irreg margin (microlobulated/spiculated)
hypoechoic, microcalcs, irregmargin
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Intermediate Pattern 10-20%
Hypoechoic without:• Microcalcifications• Taller than wide shape• Infiltrative borders• Abnormal lymph nodes
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LOW Suspicion Pattern 5-10%
isoechoic solid reg margins hyperechoic solid reg margins
partially cystic with eccentric solid areas
WITHOUT: MicroCa,, Irregular Margin, Taller than Wide or Extra-thyroidal Extension
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VERY LOW Suspicion Pattern <3%
spongiform
partially cystic no suspicious features, note solid areas
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BENIGN
pure cyst
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R8 US Pattern and suggested FNA cutoffs
Sonographic
Pattern
Estimated
malignancy
risk
FNA size
cutoff
Strength of rec
Quality of evidence
High suspicion >70-90% > 1 cm Strong Moderate
Intermediate
suspicion
10-20% > 1 cm Strong Low
Low suspicion 5-10% > 1.5 cm Weak Low
Very low
suspicion
< 3% > 2 cm Weak Moderate
One option is surveillance
Benign < 1% No biopsy Strong Moderate
FNA is not recommended for nodules that do not meet the above criteria, including all nodules < 1 cm
Strong Moderate
Haugen et al. Thyroid; January 2016
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Sonographic
PatternStrength of rec
Quality of evidence
High
suspicionRepeat US and US FNA within 12 months
Strong Moderate
Intermediate/
Low
suspicion
Repeat US at 12-24m If growth or new suspicious US feature, repeat FNA OR continued observation
Weak Low
Very low
suspicion
Utility of surveillance US and assessment of nodule growth as an indicator for repeat FNA is not known. If repeated, US should at >24 months
Weak Low
IF 2nd US FNA done with benign cytology, US surveillance for continued risk of malignancy is no longer indicated
Strong Moderate
R23 Follow-up of nodules with benign cytology
Haugen et al. Thyroid; January 2016
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Sonographic
PatternStrength of rec
Quality of evidence
High
suspicionRepeat US 6-12 months Weak Low
Intermediate/
Low
suspicion
Repeat US at 12-24m Weak Low
Very low
suspicion> 1cm: Utility and time interval of repeat US for risk of malignancy is not known. If repeated, do at > 24 months
NO rec Insufficient
<1cm: Do not require routine US surveillance
Weak Low
R24 Recommended follow-up of nodules that have not undergone FNA
Haugen et al. Thyroid; January 2016