154 �

REFERENCES

Abbott, W.S. 1925. A method of computing the effectiveness of an insecticide.

Journal of Economic Entomology, 18: 265-267.

Abdullahi, I., Winter, S., Atiri, G.I. and Thottappilly, G. 2003. Molecular

characterization of whitefly, Bemisia tabaci (Hemiptera: Aleyrodidae)

populations infesting Cassava. Bulletin of Entomological Research,

93(2): 97-106.

Abgali, A.Z. and Alavo, T.B. 2011. Essential oil from bush mint, Hyptis suaveolens,

is as effective as DEET for personal protection against mosquito bites.

The Open Entomology Journal, 5: 45-48.

Abu-Shanab, B., Adwan, G., Abu-Safiya, D., Jarrar, N. and Adwan, K. 2004.

Antibacterial activities of some plant extracts utilized in popular medicine in

Palestine. Turkish Journal of Biology, 28(2): 99-102.

Adda, C., Atachi, P., Hell, K. and Tamo, M. 2011. Potential use of the bush mint

Hyptis suaveolens for the control of infestation by the pink stalk borer,

Sesamia calamistis on maize in southern Benin, West Africa. Journal of Insect

Science, 11(33): 1-13.

Adewusi, E.A. and Steenkamp, V. 2011. In vitro screening for acetylcholinesterase

inhibition and antioxidant activity of medicinal plants from southern Africa.

Asian Pacific Journal of Tropical Medicine, 4(10): 829-835.

Agarwal, K. and Varma, R. 2013. Antioxidant activity and phytochemical analysis of

Hyptis suaveolens (L.) Poit. Journal of Advanced Pharmaceutical Education

and Research, 3(4): 541-549.

Aguirre, C., Castro-Guillen, J.L., Contreras, L., Mendiola-Olaya, E., Gonzalez de la

Vara, L. and Blanco-Labra, A. 2009. Partial characterization of

chrymotrypsin-like protease in the larger grain borer (Prostephanus truncates

(Horn) in relation to activity of Hyptis suaveolens L. trypsin inhibitor. Journal

of Stored Products Research, 45(2): 133-138.

155 �

Aguirre, C., Torres, I., Mendoza-Hernandez, G., Garcia-Gasea, T. and Blanco-Labra,

A. 2012. Analysis of protein fractions and some minerals in Chan

(Hyptis suaveolens L.) seeds. Journal of Food Science, 77(1): C15-C19.

Ahmad, I., Mehamood, Z. and Mohammad, F. 1998. Screening of some Indian

medicinal plants for their antimicrobial properties. Journal of

Ethnopharmacology, 62(2): 183–193.

Ahmad, J., Khan, I., Ahmad, A. and Imam, K. 2013. In vitro antioxidant and

antimicrobial activity of methanolic root extracts of Hyptis suaveolens.

Research Journal of Recent Sciences, 2(ISC-2012): 41-46.

Ahmed, M., Scora, R.W. and Ting, I.P. 1994. Composition of leaf oil of Hyptis

suaveolens (L.) Poit. Journal of Essential Oil Research, 6(6): 571–575.

Ajaiyeoba, E.O., Onocha, P.A. and Olarenwaju, O.T. 2001. In vitro anthelmintic

properties of Buchholzia coriaceae and Gynandropsis gynandra extract.

Pharmaceutical Biology, 39(3): 217-220.

Akinnibosun, F.I., Akinnibosun, H.A. and Ogedegbe, D. 2009. Investigation on the

antibacterial activity of aqueous and ethanolic extracts of leaves of Boerhavia

diffusa. Science World Journal, 4(2): 15-18.

Akkarachiyasit, S., Charoenlertkul, P., Yibchok-anun, S. and Adisakwattana, S. 2010.

Inhibitory activities of cyanidin and its glycosides and synergistic effect with

acarbose against intestinal �-glucosidase and pancreatic �-amylase.

International Journal of Molecular Sciences, 11(9): 3387-3396.

Akobundu, I.O. and Agyakwa, C.W. 1998. A Hand Book on West African Weeds.

International Institute of Tropical Agriculture, 2nd edition, Ibadan,

Nigeria, p. 496.

Akrout, A., Jani, E.H., Zammouri, T., Mighri, H. and Neffati, M. 2010.

Phytochemical screening and mineral contents of annual plants growing wild

in the southern of Tunisia. Journal of Phytology, 2(1): 34–40.

Alarcon-Aguilara, F.J., Roman-Ramos, R., Perez-Gutierrez, S., Aguilar-Contreras, A.,

Contreras-Weber, C.C. and Flores-Saenz, J.L. 1998. Study of the

antihyperglycemic effect of plants used as antidiabetics. Journal of

Ethnopharmacology, 61(2): 101-110.

156 �

Al-Dabbas, M., Hashinaga, F., Abdelgaleil, S., Suganuma, T., Akiyama, K. and

Hayashi, H. 2005. Antibacterial activity of an eudesmane sesqueiterpene

isolated from common Varthemia, Varthemia iphionoides.

Ethnopharmacology, 97(2): 237-240.

Ali, M.S., Yaghmour, R.M., Faidi, Y.R., Salem, K. and Al-Nuri, M.A. 1998.

Antimicrobial activity of 20 plants used in folkloric medicine in the

Palestinian area. Journal of Ethnopharmacology, 60(3): 265-271.

Ali, S.G., Rab, A., Khan, N.U. and Nawab, K. 2011. Enhanced proline synthesis may

determine resistance to salt stress in tomato cultivars. Pakistan Journal of

Botany, 43(6): 2707-2710.

Ambasta, S.P. 1986. The Useful Plants of India. Publication and Information

Directorate, CSIR, New Delhi, India, pp. 608-609.

Ammara, H., Salma, R. and Farah, D. 2009. Antimicrobial activity of some plant

extracts having hepatoprotective effects. Journal of Medicinal Plant Research,

3(1): 20-23.

Anis, E., Anis, I., Ahmed, S., Mustafa, G., Malik, A., Afza, N., Hai, S.M.,

Shahzad-ul-hussan, S. and Choudhary, M.I. 2002. α-glucosidase inhibitory

constituents from Cuscuta reflexa. Chemical and Pharmaceutical Bulletin,

50(1): 112-114.

Anjana, S., Rani, V. and Padmini, R. 2009. Antibacterial activity of some medicinal

plants used by tribals against UTI causing pathogens. World Applied Sciences

Journal, 7: 332-339.

Annegowda, H.V., Nee, C.W., Mordi, M.N., Ramanathan, S. and Mansor, S.M. 2010.

Evaluation of phenolic content and antioxidant property of hydrolysed

extracts of Terminalia catappa L. leaf. Asian Journal of Plant Sciences,

9(8): 479-485.

Anonymous, 1964. Wealth of India-Raw Materials, Vol. V, CSIR, New Delhi, p. 159.

Anonymous, 2001. Wealth of India: A Dictionary of Indian Raw Materials and

Industrial Products-Raw Materials Series, Publications and

Information Directorate, Council of Scientific and Industrial Research, New

Delhi,5: 158-159.

157 �

Anurakkun, N.J., Bhandari, M.R. and Kawabata, J. 2007. �-glucosidase inhibitors

from Devil tree (Alstonia scholaris). Food Chemistry, 103(4): 1319–1323.

AOAC, 1990. Official Methods of Analysis. Association of Official Analytical

Chemists, 15th edition, Washington, DC.

Arivoli, S. and Samuel, T. 2011. Mosquitocidal activity of Hyptis suaveolens (L.)

Poit. (Lamiaceae) extracts against Aedes aegypti, Anopheles stephensi and

Culex quinquefasciatus (Diptera: Culicidae). International Journal of Recent

Scientific Research, 2(5): 143-149.

Arokiyaraj, S., Martin, S. and Perinbam, K. 2008. Free radical scavenging activity and

HPTLC finger print of Pterocarpus santalinus an in vitro study. Indian

Journal of Science and Technology, 1(7): 1-7.

Asekun, O.T., Ekundayo, O. and Adeniyi, B.A. 1999. Antimicrobial activity of the

essential oil of Hyptis suaveolens leaves. Fitoterapia, 70(4): 440-442.

Asekun, O.T. and Ekundayo, O. 2000. Essential oil constituents of Hyptis suaveolens

(L.) Poit. (Bush Tea) leaves from Nigeria. Journal of Essential Oil Research,

12(2): 227-230.

Avaligbe, C.T., Gbenou, J.D., Kpoviessi, D.S.S., Accrombessi, G.C., Moudachirou,

M. and Gbeassor, M. 2012. Antihemolytic properties of extracts of six plants

used in the traditional treatment of Sickle cell disease in Benin. Journal of

Applied Pharmaceutical Science, 2(3): 8-13.

Avato, P. 2005. A survey of the Hypericum genus: secondary metabolites and

bioactivity. Studies in Natural Product Chemistry, 30: 603–634.

Azeez, G.O., Lawal, I.A., Muriana, M., Adeniji, S.T. and Hammed, T.B. 2014.

Chemical composition of Hyptis suaveolens grown in Saki, South Western

Nigerian, for its resource recovery. International Journal of Development

Research, 4(8): 1765-1767.

Azevedo, N.R., Campos, I.F., Ferreira, H.D., Portes, T.A., Santos, S.C., Seraphin,

J.C., Paula, J.R. and Ferri, P.H. 2001. Chemical variability in the essential oil

of Hyptis suaveolens. Phytochemistry, 57(5): 733-736.

158 �

Baker, E.A. 1982. Chemistry and morphology of plant epicuticular waxes. In: Cutler,

D.F., Alvin, K.L. and Price, C.E. (eds.), The Plant Cuticle. Academic Press,

London, pp. 139-165.

Bakkali, F., Averbeck, S., Averbeck, D. and Idaomar, M. 2008. Biological effects of

essential oils-a review. Food and Chemical Toxicology, 46(2): 446–475.

Balakrishnan, N., Panda, A.B., Raj, N.R., Shrivastava, A. and Prathani, R. 2009.

The evaluation of nitric oxide scavenging activity of Acalypha indica Linn.

root. Asian Journal of Research in Chemistry, 2(2): 148-150.

Balick, J.M. and Cox, P.A. 1996. Plants, People and Culture-The Science of

Ethnobotany. Scientific American Library, New York, pp. 228-235.

Barbosa, L.C.A., Martins, F.T., Teixeira, R.R., Polo, M. and Montanari, R.M. 2013.

Chemical variability and biological activities of volatile oils from Hyptis

suaveolens (L.) Poit. Agriculturae Conspectus Scientificus, 78(1): 1-10.

Barbour, E., Sharif, M.A., Sagherian, V.K. and Habre, A.N. 2004. Screening of

selected indigenous plants of Lebanon for antimicrobial activity. Journal of

Ethnopharmacology, 93(1): 1-7.

Barrett, A., Ndou, T., Hughey, C.A., Straut, C., Howell, A., Dai, Z. and Kaletunc, G.

2013. Inhibition of �-amylase and glucoamylase by tannins extracted from

cocoa, pomegranates, cranberries, and grapes. Journal of Agricultural and

Food Chemistry, 61(7): 1477-1486.

Bauer, A.W., Kirby, W.M., Sherris, J.C. and Turck, M. 1966. Antibiotic susceptibility

testing by a standardized single disk method. American Journal of Clinical

Pathology, 45(4): 493-496.

Beauchamp, C. and Fridovich, I. 1971. Superoxide dismutase: Improved assays

and an assay applicable to acrylamide gels. Analytical Biochemistry,

44(1): 276-287.

Benelli, G., Flamini, G., Canale, A., Molfetta, I., Cioni P.L. and Conti, B. 2012.

Repellence of Hyptis suaveolens whole essential oil and major constituents

against adult granary weevil Sitophilus granarius. Bulletin of Insectology,

65(2): 177-183.

159 �

Bhagwat, D.P. and Umathe, S.N. 2003. The immunomodulatory activity of Hyptis

suaveolens (L.) Poit., family- Lamiaceae. Indian Journal of Pharmacology,

35: 128-36.

Bhattacharyya, R., Bhattacharya, S. and Chaudhuri, S. 2006. Conservation and

documentation of the medicinal plant resources of India. Biodiversity and

Conservation, 15(8): 2705-2717.

Bimal, K., Rai, B.K. and Nisha, A. 2011. Synthesis, characterization and

antimicrobial screening of Cobalt(II), Nickel(II) and Copper(II) complexes

with schiff base derived from 2-Phenyl Quinoxaline Thiosemicarbazone.

Oriental Journal of Chemistry, 27(3): 1173-1178.

Blois, M.S. 1958. Antioxidant determinations by the use of a stable free radical.

Nature, 26: 1199-1200.

Bohannon, N.J.V. 2002. Treating dual defects in diabetes: Insulin resistance and

insulin secretion. American Journal of Health Systems Pharmacy, 59(9): 9-13.

Bundy, D.A.P. 1994. The global burden of intestinal nematode disease. Transactions

of the Royal Society of Tropical Medicine and Hygiene, 88(3): 259 – 261.

Cai, J., Yang, J. and Jones, D.P. 1998. Mitochondrial control of apoptosis; the role of

cytochrome C. Biochemica et Biophysica Acta, 1366(1): 139-149.

Cai, Z., Tsung, E.F., Marinescu, V.D., Ramoni, M.F., Riva, A. and Kohane, I.S. 2004.

Bayesian approach to discovering pathogenic SNPs in conserved protein

domains. Human Mutation, 24(2): 178-184.

Cao, G., Sofic, E. and Prior, R.L. 1997. Antioxidant and prooxidant behavior of

flavonoids: structure-activity relationships. Free Radical Biology and

Medicine, 22(5): 749–60.

Cavalcanti, E.S.B., Morais, S.M., Lima, M.A.A. and Santana, E.W.P. 2004.

Larvicidal activity of essential oils from Brazilian plants against Aedes aegypti

L. Memorias Instituto Oswaldo Cruz, 99(5): 541-544.

160 �

Cecile, C., Liagre, B., Terro, F. and Beneytout, J.L. 2004. Induction of

antiproliferative effect by diosgenin through activation of p53, release of

Apoptosis-Inducing Factor (AIF) and modulation of caspase-3 activity in

different human cancer cells. Cell Research, 14(3): 188-196.

Cespedes, C.L., El-Hafidi, M., Pavon, N. and Alarcon, J. 2008. Antioxidant and

cardioprotective activities of phenolic extracts from fruits of Chilean

blackberry Aristotelia chilensis (Elaeocarpaceae), Maqui. Food Chemistry,

107(2): 820–829.

Chakraborty, D. and Shah, B. 2011. Antimicrobial, antioxidant and antihemolytic

activity of Piper betel leaf extracts. International Journal of Pharmacy and

Pharmaceutical Sciences, 3(3): 192-199.

Chanda, S. and Dave, R. 2009. In vitro models for antioxidant activity evaluation and

some medicinal plants possessing antioxidant properties: an overview. African

Journal of Microbiology Research, 3(13): 981-996.

Chang, S., Sievert, D.M. and Hageman, J.C. 2003. Infection with Vancomycin

resistant Staphylococcus aureus containing the vanA resistance gene. The New

England Journal of Medicine, 348(14): 1342-1347.

Chatri, M., Baktiar, A., Mansyurdiin and Adnadi, P. 2014. Chemical components of

essential oils of the leaves of Hyptis suaveolens (L.) Poit. from Indonesia.

American Journal of Research Communication, 2(10): 30-38.

Chatterjee, A. and Pakrashi, S.C. 1997. The Treatise on Indian Medicinal Plants, Vol.

5, Publication and Information Directorate, CSIR, New Delhi, p. 15.

Chaudhuri, S., Banerjee, A., Basu, K., Sengupta, B. and Sengupta, P.K. 2007.

Interaction of flavonoid with red blood membrane lipids and proteins:

antioxidant and antihemolytic activity. International Journal of Biological

Macromolecules, 41(1): 42–48.

Chiao, C., Carothers, A.M., Grunberger, D., Solomon, G., Preston, G.A. and Barrett,

J.C. 1995. Apoptosis and altered redox state induced by caffeic acid phenethyl

ester (CAPE) in transformed rat fibroblast cells. Cancer Research, 55(16):

3576-3583.

161 �

Chiasson, J.L., Josse, R.G. and Hunt, J.A. 1994. Efficacy of acarbose in the treatment

of patients with non-insulin dependent diabetes mellitus- a multi control

clinical trial. Annals of Internal Medicine, 121: 928-935.

Christou, L., Hatzimichael, E., Chaidos, A., Tsiara, S. and Bourantas, K.L. 2001.

Treatment of plasma cell leukemia with vincristine, liposomal doxorubicin and

dexamethasone. European Journal of Haematology, 67(1): 51-53.

Chugh, T.D. 2008. Emerging and re-emerging bacterial diseases in India. Journal of

Biosciences, 33(4): 549-555.

Chukwujekwu, J.C., Smith, P., Coombes, P.H., Mulholland, D.A. and van Staden, J.

2005. Antiplasmodial diterpenoid from the leaves of Hyptis suaveolens.

Journal of Ethnopharmacology, 102(2): 295-7.

Conforti, F., Statti, G., Loizzo, M.R., Sacchetti, G., Poli, F. and Menichini, F. 2005.

In vitro antioxidant effect and inhibition of �-amylase of two varieties of

Amaranthus caudatus seeds. Biological and Pharmaceutical Bulletin,

28(6): 1098-1102.

Conti, B., Canale, A., Bertoli, A., Gozzini, F. and Pistelli, L. 2010. Essential oil

composition and larvicidal activity of six Mediterranean aromatic plants

against the mosquito Aedes albopictus (Diptera: Culicidae). Parasitology

Research, 107(6): 1455-1461.

Cox, P.A. 1994. The ethnobotanical approach to drug discovery; strengths and

limitations. Ethnobotany and the Search for New Drugs, 185: 25-41.

Cox, S.D., Gustafson, J.E., Mann, C.M., Markham, J.L., Liew, Y.C., Hartland, R.P.,

Bell, H.C., Warmington, J.R. and Wyllie, S.G. 1998. Tea tree oil causes K+

leakage and inhibits respiration in Escherichia coli. Letters in Applied

Microbiology, 26(5): 355-358.

Dai, F., Miao, Q., Zhou, B., Yang, L. and Liu, Z.L. 2006. Protective effect of

flavonols and their glycosides against free radical induced oxidative hemolysis

of red blood cells. Life Sciences, 78(21): 2488–2493.

Dalziel, J. M. 1937. The Useful Plants of West Tropical Africa. Crown Agencies for

the colonies publication, London, p. 461.

162 �

Dandiya, P.C. and Kulkarni, S.K. 2005. Introduction to Pharmacology, Vallabh

Prakashan, New Delhi, pp. 170-171.

Danmalam, U.H., Abdullahi, L.M., Agunu, A. and Musa, K.Y. 2009. Acute toxicity

studies and hypoglycemic activity of the methanol extract of the leaves of

Hyptis suaveolens Poit. (Lamiaceae). Nigerian Journal of Pharmaceutical

Sciences, 8(2): 87-92.

Das, N.G., Goswami, D. and Rabha, B. 2007. Preliminary evaluation of

mosquito larvicidal efficacy of plant extracts. Journal of Vector Borne

Diseases, 44(2): 145–148.

Das, P.K., Sahoo, S., Sethi, R., Nayak, P.S., Nayak, S. and Joshi, A. 2009.

Phytochemical and pharmacological investigation of the protective effect of

plant Hyptis suaveolens against duodenal unceration. Journal of Global

Pharma Technology, 1(1): 82-87.

Davis, S.N. and Granner, D.K. 2001. Insulin, oral hypoglycemic agents and the

pharmacology of endocrine pancreas. In: Brunton, L.L., Lazo, J.S. and Parker,

K.L. (eds.), Goodman and Gilman’s: The Pharmacological Basis of

Therapeutics, 11th ed. McGraw-Hill Medical Publication Division; New

York, pp. 1679-1714.

Devaki, K., Beulah, U., Akila, G., Narmadha, R. and Gopalakrishnan, V.K. 2011.

Glucose lowering effect of aqueous extract of Bauhinia tomentosa L. on

alloxan induced type 2 diabetes mellitus in wistar albino rats. Journal of Basic

and Clinical Pharmacy, 2(4): 167-174.

Devjani, C. and Verma, R.J. 2010. Ameliorative effect of Emblica officinalis aqueous

extract against ochratoxin – induced lipid peroxidation in the kidney and liver

of mice. International Journal of Occupational Medicine and Environmental

Health, 23: 1-11.

Dhiman, A.K. 2003. History of Indian Medicine and Pharmacopoeia. Aryavaidhyan,

17(1): 24-31.

Din, L., Zakaria, Z., Sandudin, M.W., Brophy, J. and Toia, R.F. 1988. Composition of

the steam volatile oil from Hyptis suaveolens. Pertanika, 11(2): 239-247.

163 �

Dive, C., Gregory, C.D., Phipps, D.J., Evans, D.L., Milner, A.E. and Wyllie, A.H.

1992. Analysis and discrimination of necrosis and apoptosis (programmed cell

death) by multiparameter flow cytometry. Biochimica et Biophysica Acta.,

1133(3): 275-285�

Durga, A.J., Acosta, J.C., Bonin, G.C., Prince, K.L., Fischer, N.H. and Winston, G.W.

2000. Evaluation of total peroxyl radical scavenging capacity of flavonoids,

structure activity relationships. Journal of Natural Products, 63(3): 327-331.

Earnshaw, W.C. 1995. Nuclear changes in apoptosis. Current Opinion in Cell

Biology, 7(3): 337– 343.

Easu, K. 1964. Plant Anatomy. John Wiley and Sons, New York, p. 767.

Ebrahimzadeh, M.A., Ehsanifar, S. and Eslami, B. 2009. Sambucus ebulus

elburensis fruits: a good source for antioxidants. Pharmacognosy Magazine,

4(19): 213-218.

Edeoga, H.O., Okwu, D.E. and Mbaebie, B.O. 2005. Phytochemical constituents

of some Nigerian medicinal plants. African Journal of Biotechnology,

4(7): 685-688.

Edeoga, H.O., Omosun, G. and Uche, L.C. 2006. Chemical composition of Hyptis

suaveolens and Ocimum gratissimum hybrids from Nigeria. African Journal of

Biotechnology, 5(10): 892-895.

Edwin, S., Jarald, E., Edwin, D.L., Jain, A., Kinger, H., Dutt, K.R. and Raj, A.A.

2008. Wound healing and antioxidant activity of Achyranthes aspera.

Pharmaceutical Biology, 46(12): 824-828.

Eldeen, A.M.G., Amer, H. and Helmy, W.A. 2006. Cancer chemopreventive and

anti-inflammatory activities of chemically modified Guar gum.

Chemico-Biological Interactions, 161(3): 229–240.

El-Kaissi, S. and Sherbeeni, S. 2011. Pharmacological management of type 2 diabetes

mellitus: an update. Current Diabetes Reviews, 7(6): 392-405.

Eloff, J.N. 1999. It is possible to use herbarium specimens to screen for antibacterial

components in some plants. Journal of Ethnopharmacology, 67(3): 355-360.

164 �

Eloff, J.N. 2004. Quantifying the bioactivity of plant extracts during screening and

bioassay-guided fractionation. Phytomedicine, 11: 370-371.

Elumalai, K., Mathivanan, T., Elumalai, A., Jeyasankar, A., Dhanasekaran, S. and

Krishnappa, K. 2013. Larvicidal and ovicidal properties of selected Indian

medicinal plants extracts against American bollworm, Helicoverpa armigera

(Hub.) (Lepidoptera: Noctuidae). International Journal of Interdisciplinary

Research and Reviews, 1(7): 5-11.

Eom, S.H., Lee, S.H., Yoon, N.Y., Jung, W.K., Jeon, Y.J., Kim, S.K., Lee, M.S. and

Kim, Y.M. 2012. �-glucosidase and �-amylase inhibitory activities of

phlorotannins from Eisenia bicyclis. Journal of the Science of Food and

Agriculture, 92(10): 2084-2090.

Essawi, T. and Srour, M. 1999. Screening of some Palestinian medicinal plants for

antibacterial activity. Journal of Ethnopharmacology, 70(3): 343-349.

Evans, W.C. 1996. Trease and Evans Pharmacognosy, 14th edition, Bailiere Tindall,

W.B. Sauders company Ltd, London, pp. 224-228.

Fabricant, D.S. and Farnsworth, N.R. 2001. The value of plants used in

traditional medicine for drug discovery. Environmental Health Perspectives,

109 (1): 69-75.

Fan, T.J., Han, L.H., Cong, R.S. and Liang. J. 2005. Caspase family proteases and

apoptosis. Acta Biochemica et Biophysica Sinica, 37(11): 719–727.

Farnsworth, N.R. 1994. Ethnopharmacology and drug development. In: Prance, G.T.

(ed.), Ethnobotany and the Search for New Drugs.Wiley, Chichester, Ciba

Foundation Symposium 185, pp. 42-59.

Finkel, T. and Holbrook, N.J. 2000. Oxidants, oxidative stress and the biology of

ageing. Nature, 408(6809): 239-247.

Fisher, D.E. 1994. Apoptosis in cancer therapy; crossing the threshold.

Cell, 78(4): 539-542.

Fox, T.R. 1999. Aloe vera revered. Mystery Healer. Health Foods Business,

pp. 45-46.

165 �

Fun, C.E. and Svendsen, A.B. 1990. The essential oil of Hyptis suaveolens grown in

Aruba. Flavour and Fragrance Journal, 5(3): 161-3.

Garg, S.K. 1976. Anti fertility screening of plants effect of 4 indigenous plants on

early pregnancy in female albino rats. Indian Journal of Medical Research,

64(8): 1133-1135.

Gavani, U. and Paarakh, P.M. 2008. Antioxidant activity of Hyptis suaveolens Poit.

International Journal of Pharmacology, 4(3): 227-229.

Gbolade, A.A., Oyedele, A.O., Sosan, M.B., Adewayin, F.B. and Soyela, O.L. 2000.

Mosquito repellent activities of essential oils from two Nigerian Ocimum

species. Journal of Tropical Medicinal Plants, 1(1/2): 146-148.

Geissman, T.A. 1963. Flavonoid compounds, tannins, lignins and related compounds.

In: Florkin, M. and Stotz, E.H. (ed.), Pyrrole Pigments, Isoprenoid

Compounds and Phenolic Plant Constituents, Vol. 9. Elsevier, New York,

p. 265.

George, S., Bhalerao, S.V. and Lidstone, E.A. 2010. Cytotoxicity screening of

Bangladeshi medicinal plant extracts on pancreatic cancer cells.

BMC Complementary and Alternative Medicine, 10(1): 52-55.

Ghaffari, H., Ghassam, B.J., Nayaka, S.C., Kini, K.R. and Prakash, H.S. 2014.

Antioxidant and neuroprotective activities of Hyptis suaveolens (L.) Poit.

against oxidative stress-induced neurotoxicity. Cellular and Molecular

Neurobiology, 34(3): 323-331.

Ghavami, A., Johnston, B.D., Jensen, M.T., Svensson, B. and Pinto, B.M. 2001.

Synthesis of nitrogen analogues of salacinol and their evaluation

as glycosidase inhibitors. Journal of American Chemical Society, 123(26):

6268-6271.

Ghayal, N., Padhye, A. and Dhumal, K. 2010. Larvicidal activity of invasive weeds

Cassia uniflora and Synedrella nodiflora. International Journal of Pharma

and BioSciences, 1(3): 1-10.

Ghosh, A., Chowdhury, N., and Chandra, G. 2012. Plant extracts as potential

mosquito larvicides. The Indian Journal of Medical Research, 135(5):

581-584.

166 �

Gilani, A.H. 2005. Trends in ethnopharmacology. Journal of Ethnopharmacology,

100(1): 43-49.

Gordon, M.F. 1990. The mechanism of antioxidant action in vitro. In: Hudson, B.J.F.

(ed.), Food Antioxidants. Elsevier Applied Science, London, pp. 1-18.

Gottlieb, R.A. 2000. Mitochondria execution central. FEBS Letters, 482(1): 6-12.

Govindarajan, R., Vijayakumar, M. and Pushpangadan, P. 2005. Antioxidant

approach to disease management and the role of ‘Rasayana’ herbs of

Ayurveda. Journal of Ethnopharmacology, 99(2): 165-178.

Gowda, D. 1984. Polysaccharide components of the seed-coat mucilage from Hyptis

suaveolens. Phytochemistry, 23(2): 337-338.

Grassi, P., Urias Reyes, T.S., Sosa, S., Tubaro, A., Hofer, O. and Zitterl-Eglseer, K.

2006. Anti-inflammatory activity of two diterpenes of Hyptis suaveolens from

El Salvador. Zeitschrift fur Naturforschung, 61(3-4): 165-170.

Green, D. and Kroemer, G. 1998. The central executioners of apoptosis; caspases or

mitochondria? Trends in Cell Biology, 8(7): 267-271.

Green, D.R. and Reed, J.C. 1998. Mitochondria and apoptosis. Science, 281(5381):

1309-1312.

Griggs, J.K., Towers, G.H.N. and Taylor, R.S. 2001. The effects of storage on the

biological activity of medicinal plants from Nepal. Journal of

Ethnopharmacology, 77(2): 247-252.

Grover, J.K., Vats, V., Rathi, S.S. and Dawar, R. 2001. Traditional Indian antidiabetic

plants attenuate renal hypertrophy, urine volume and albuminuria in

streptozotocin induced diabetic mice. Journal of Ethnopharmacology,

76: 233-238.

Gülçin, Ì., �at, �.G., Beydemir, �., Elmasta�, M. and Küfrevioglu, Ö.�. 2004.

Comparison of antioxidant activity of clove (Eugenia caryophylata Thunb)

buds and lavender (Lavandula stoechas L.). Food Chemistry, 87(3): 393– 400.

Gurunagarajan, S. and Pemaiah, B. 2011. Comparative studies on cytotoxic effect of

Hyptis suaveolens Poit. and Leonotis nepeatefolia R.Br. against EAC cell

lines. Journal of Pharmacy Research, 4(4): 1222-1224.

167 �

Habbal, O., Hasson, S.S., El-Hag, A.H., Al-Mahrooqi, Z., Al-Hashmi, N., Al-Bimani,

Z., Al-Balushi, M.S. and Al-Jabri, A.A. 2011. Antibacterial activity of

Lawsonia inermis Linn. (Henna) against Pseudomonas aeruginosa. Asian

Pacific Journal of Tropical Biomedicine, 1(3): 173-176.

Hagerman, A.E., Riedl, K.M., Jones, G.A., Sovik, K.N., Ritchard, N.T., Hartzfeld,

P.W. and Riechel, T.L. 1998. High molecular weight plant polyphenolics

(tannins) as biological antioxidants. Journal of Agriculture and Food

Chemistry, 46(5): 1887-1892.

Halliwell, B. 1991. Reactive oxygen species in living systems: source, biochemistry

and role in human disease. American Journal of Medicine, 91(3): 14-22.

Halliwell, B. 2000. The antioxidant paradox. The Lancet, 355(9210): 1179-1180.

Hang, W. and Lautzsch, H.J. 1983. Comparative methods for the rapid determination

of Palestian cereal products. Journal of the Science of Food and Agriculture,

34: 1423-1426.

Harborne, S.B. and Baxter, H. 1995. Phytochemical Dictionary-A Handbook of

Bioactive Compounds from Plants, Taylor and Francis, Cambridge University

Press, London, p. 76.

Harborne, J.B. 1998. Phytochemical Methods-A Guide to Modern Techniques of Plant

Analysis, 3rd edition, Chapman and Hall, London, p. 302.

Heinrich, M., Heneka, B., Ankli, A., Rimpler, H., Sticher, O. and Kostiza, T. 2005.

Spasmolytic and antidiarrhoeal properties of the Yucatec Mayan medicinal

plant Casimoroa tetramesia. Journal of Pharmacy and Pharmacology,

57: 1081-1085.

Hill, A.F. 1952. Economic botany. A text book of useful plants and plant products.

2nd Edition. Mcgraw-Hill Book Company Inc., New York, pp. 457-560.

Hirano, T., Abe, K., Gotoh, M. and Oka, K. 1995. Citrus flavone tangeretin inhibits

leukaemic HL-60 cell growth partially through induction of apoptosis with

less cytotoxicity on normal lymphocytes. British Journal of Cancer, 72(6):

1380-1388.

168 �

Hoult, J.R.S. and Payá, M. 1996. Pharmacological and biochemical actions of simple

coumarins-natural products with therapeutic potential. General Pharmacology,

27(4): 713-722.

Huang, Q., Roessner, C.A., Croteau, R. and Scott, A.I. 2001. Engineering Escherichia

coli for the synthesis of taxadiene, a key intermediate in the biosynthesis of

taxol. Bioorganic and Medicinal Chemistry, 9(9): 2237–2242.

Husain, S.R., Cillard, J. and Cillard, P. 1987. Hydroxyl radical scavenging activity of

flavonoids. Phytochemistry, 26(9): 2489-2491.

Ibrahim, M.B. 1997. Anti-microbial effects of extract leaf, stem and root bark of

Anogeissus leiocarpus on Staphylococcus aureus, Streptococcus pyogenes,

Escherichia coli and Proteus vulgaris. Journal of Pharmaceutical

Development, 2: 20-30.

Idu, M., Omogbai, E.K.I., Aghimien, G.E.I. and Amaechina, F. 2007. Preliminary

phytochemistry, antimicrobial properties and acute toxicity of Stachytarpheta

jamaicensis (L.) Vahl. leaves. Trends in Medical Research, 2(4): 193-198.

Ijeh, I.I., Edeoga, H.O., Jimoh, M.A. and Ejeke, C. 2007. Preliminary phytochemical,

nutritional and toxicological studies of leaves and stems of Hyptis suaveolens.

Research Journal of Pharmacology, 1(2): 34-36.

Ikenebomeh, M.J. and Metitiri, P.O. 1988. Antimicrobial effect of an extract from

Cassia alata. Nigerian Journal of Microbiology, 8: 12-23.

Irudayaraj, V., Janaky, M., Johnson, M. and Selvan, N. 2010. Preliminary

Phytochemical and antimicrobial studies on a spike-moss Selaginella

inaequalifolia (Hook. & Grev.) Spring. Asian Pacific Journal of Tropical

Medicine, 3(12): 957-960.

Islam, E., Khatune, N.A., Wahed, M.I.I., Md Haque, E. and Md Mosaddik, A. 2003.

Larvicidal activity of a new glycoside, Phenyl Ethyal–D Glycopyranoside

from the stem of the plant Sida rhombifolia, Pakistan Journal of Biological

Sciences, 6(1): 73-7.

Ismail, M.Y.M. 2009. Clinical evaluation of antidiabetic activity of Trigonella seeds

and Aegle marmelos leaves. World Applied Sciences Journal, 7(10):

1231-1234.

169 �

Ivoke, N., Okafor, F.C. and Owoicho, L.O. 2009. Evaluation of ovicidal and larvicidal

effects of leaf extracts of Hyptis suaveolens (L.) Poit. (Lamiaceae) against

Anopheles gambiae (Diptera: Anophelidae) complex. Animal Research

International, 6(3): 1072–1076.

Iwu, M.M., Ezeugwu, C.O., Okunji, C.O., Sanson, D.R. and Tempesta, M.S. 1990.

Antimicrobial activity and terpenoids of the essential oil of Hyptis suaveolens.

Pharmaceutical Biology, 28(1): 73-76.

Iwu, M.W., Duncan, D.R. and Okunji, C.O. 1999. New antimicrobials of plant origin.

In; Perspective on new crops and new uses. American shared hospital services

Press. Alexandria, pp. 107-108.

Jabeen, R., Shahid, M., Jamil, A. and Ashraf, M. 2008. Microscopic evaluation of the

antimicrobial activity of seed extracts of Moringa oleifera. Pakistan Journal

of Botany, 40: 1349-1358.

Jafri, M.A., Aslam, M., Javed, K. and Singh, S. 2000. Effect of Punica granatum

Linn. (flowers) on blood glucose level in normal and alloxan induced diabetic

rats. Journal of Ethnopharmacology, 70(3): 309-314.

Jäger, A.K., Hutchings, A. and van Staden, J. 1996. Screening of Zulu medicinal

plants for prostaglandin-synthesis inhibitors. Journal of Ethnopharmacology,

52(2): 95-100.

Jain, S., Jain, V. and Bhagwat, D. 2010. The Immunomodulation Potential of Hyptis

suaveolens. International Journal of Pharmaceutical Research and

Development, 1(11): 1-6.

Jelani, S. and Prabhakar, M. 1991. Pharmacognostic study of leaf of Hyptis

suaveolens L. Ancient Science of Life, 11(1-2): 31.

Jiang, M.C., Yang-Yen, H.F., Yen, J.J. and Lin, J.K. 1996. Curcumin induces

apoptosis in immortalized NIH 3T3 and malignant cell line. Nutrition and

Cancer, 26: 111-120.

Johansen, D.A. 1940. Plant Microtechnique. McGraw-Hill Book Co., Inc., New York

and London, p. 523.

170 �

Johnson, M., Wesely, E.G., Kavitha, M.S. and Uma, V. 2011. Antibacterial activity of

leaves and inter-nodal callus extracts of Mentha arvensis L. Asian Pacific

Journal of Tropical Medicine, 4(3): 196-200.

Jørgen, L. 1988. Chemistry and biology of naturally-occuring acetylenes and related

compounds In: Proceedings of a Conference on the Chemistry of Naturally-

Occuring Acetylenes and Related Compounds (NOARC), Elsevier,

Amsterdam.

Jose, G.S. and Radhamany, P.M. 2013. In vitro antioxidant activities, total phenolics

and flavonoid of wild edible mushroom Macrolepiota mastoidea (Fr.) Singer.

International Journal of Pharmacy and Pharmaceutical Sciences, 5(2): 1-6.

Joy, K.L. and Kuttan, R. 1999. Antidiabetic activity of Picrorrhiza kurroa extract.

Journal of Ethnopharmacology, 67(2): 143-148.

Kandemir, N. 2003. The morphological, anatomical and caryological properties of

endemic Salvia hypargeia Fich. & Mey. (Lamiaceae) in Turkey. Pakistan

Journal of Botany, 35(2): 219-236.

Kandra, L., Gyémánt, G., Zajácz, A. and Battab, G. 2004. Inhibitory effects of tannin

on human salivary alpha-amylase. Biochemical and Biophysical Research

Communications, 319(4): 1265-1271.

Karuppusamy, S. 2009. A review on trends in production of secondary metabolites

from higher plants by in vitro tissue, organ and cell cultures. Journal of

Medicinal Plants Research, 3(13): 1222-1239.

Kaufmann, F., Wohlfarth, G. and Diekert, G. 1998. O-Demethylase from

Acetobacterium dehalogenans substrate specificity and function of the

participating proteins. European Journal of Biochemistry, 257(2): 515-521.

Kaya, C., Higgs, D. and Burton, A. 2000. Plant growth, phosphorus nutrition and acid

phosphatase enzyme activity in three tomato cultivars grown hydroponically at

different zinc concentrations. Journal of Plant Nutrition, 23: 569-579.

Kerr, J.F., Wyllie, A.H. and Currie, A.R. 1972. Apoptosis: a basic biological

phenomenon with wide-ranging implications in tissue kinetics. British Journal

of Cancer, 26(4): 239-257.

171 �

Khandelwal, K.R. 2007. Practical Pharmacognosy. 18th edition, Nirali Publication,

Pune, pp. 10-14.

Kim, J.S., Kwon, C.S. and Son, K.H. 2000. Inhibition of alpha-glucosidase and

amylase by luteolin, a flavonoid. Bioscience, Biotechnology and Biochemistry,

64(11): 2458-2461.

Kitts, D.D., Wijewickreme, A.N. and Hu, C. 2000. Antioxidant properties of a

North American ginseng extract. Molecular and Cellular Biochemistry,

203(1-2): 1-10.

Klein, S.M., Cohen, G. and Cederbaum, A.I. 1991. Production of formaldehyde

during metabolism of dimethyl sulphoxide by hydroxyl radical generating

system. Biochemistry, 20(21): 6006-6012.

Klipstein, G.K., Launer, L.J. and Geleijnse, J.M. 2000. Serum carotenoids and

atherosclerosis: the Rotterdam study. Atherosclerosis, 148 (1): 49-56.

Koche, D., Shirsat, R., Imran, S. and Bhadange, D.G. 2010. Phytochemical screening

of eight traditionally used ethnomedicinal plants from Akola District (MS)

India. International Journal of Pharma and Bio Sciences, 1(4): 253-256.

Kodakandla, V., Guvvala, V., Sabbu, S. and Bhukya, B. 2012. Variations in volatile

oil compositions of different wild collections of Hyptis suaveolens (L.) Poit.

from Western Ghats of India. Journal of Pharmacognosy, 3(2): 131-135.

Kogel-Knaber, I. 2000. Analytical approaches for characterizing soil organic matter.

Organic Geochemistry, 31(7): 609-625.

Koleva, I.I., Vanbreek, T.A., Linssen, J.P., Groot, A.D. and Evstatieva, L.N. 2002.

Screening of plant extracts for antioxidant activity: a comparative study on the

three testing methods. Phytochemical Analysis, 13(1): 8-17.

Komalamisra, N., Trongtokit, Y., Rongsriyam, Y. and Apiwathnasorn, C. 2005.

Screening for larvicidal activity in some Thai plants against four mosquito

vector species. Southeast Asian Journal of Tropical Medicine and Public

Health, 36(6): 1412–1422.

172 �

Koshy, P., Nurestri, A.M. and Wirakarnain, S. 2009. Antimicrobial activity of

some medicinal plants from Malaysia. American Journal of Applied Sciences,

6(8): 1613-1617.

Kossouoh, C., Mondachirou, M., Adjakidje, V., Chalchat, J.C. and Figueredo, G.

2010. A comparative study of the chemical composition of the leaves and

fruits deriving the essential oil of Hyptis suaveolens (L.) Poit from Benin.

Journal of Essential Oil Research, 22(6): 507-509.

Kudi, A.C., Umoh, J.U. and Eduvie, L.O. 1999. Screening of some Nigerian

medicinal plants for antibacterial activity. Journal of Ethnopharmacology,

67(2): 225-228.

Kumar, B.K., Raj, N.P., Kishore, K., Reddy, A.G. and Reddy, K.S. 2006. Evaluation

of Hyptis suaveolens hydro-distillate as an acaricide. Journal of Veterinary

Parasitology, 20(1): 99-100.

Kumar, P.S., Dheeba, B., Vidhyasagar, V., Arulprakash, T. and Vinothkannan, R.

2008. Potential antimicrobial activity of various extracts of Bacopa monnieri

Linn.. International Journal of Pharmacology, 4(3): 230-232.

Kumar, S. and Kumar, D. 2009. Antioxidant and free radical scavenging activities of

edible weeds. African Journal of Food, Agriculture, Nutrition and

Development, 9(5): 1174-1178.

Kumar, D., Dhamodaran, P., Nilani, P. and Balakrishna, N. 2012. Larvicidal activity

of Tephrosia purpuria against Culex quinquefasciatus. Journal of Applied

Pharmaceutical Science, 2(7): 219–221.

Kunyanga, C.N., Imungi, J.K., Okoth, M., Momanyi, C., Biesalski, H.K. and Vadivel,

V. 2011. Antioxidant and antidiabetic properties of condensed tannins in

acetonic extract of selected raw and processed indigenous food ingredients

from Kenya. Journal of Food Science, 76(4): C560-567.

Kupier�Goodman, T. and Scott, P.M. 1989. Risk assessment of mycotoxin ochratoxin

A. Biomedical and Environmental Sciences, 2(3): 179�248.

Kwon, Y., Shim, H.S., Wang, X. and Montell, C. 2008. Control of thermotactic

behavior via coupling of a TRP channel to a phospholipase C signaling

cascade. Nature Neuroscience, 11(8): 871-873.

173 �

Lai, P.K. and Roy, J. 2004. Antimicrobial and chemopreventive properties of herbs

and spices. Current Medicinal Chemistry, 11(11): 1451-1460.

Lee, J.C. and Lim, K.T. 2001. Inhibitory effects of the ethanol extract of Ulmus

davidiana on apoptosis induced by glucose-glucose oxidase and cytokine

production in cultured mouse primary immune cells. Journal of Biochemistry

and Molecular Biology, 34(5): 463- 471.

Li, S., Qui, L., Shen, Y., Xie, A., Yu, X., Zhang, L. and Zhang, Q. 2007.

Green synthesis of silver nanoparticles using Capsicum annum L. extract.

Green Chemistry, 9(8): 852-858.

Lisiewska, Z., Kmiecik, W. and Korus, A. 2006. Content of vitamin C, carotenoids,

chlorophylls and polyphenols in green parts of dill (Anethum graveolens L.)

depending on plant height. Journal of Food Composition and Analysis,

19(2): 134–140.

Long, M., Millar, D.J., Kimura, Y., Donovan, G., Rees, J., Fraser, P.D. and Bolwell,

G.P. 2006. Metabolite profiling of carotenoid and phenolic pathways in

mutant and transgenic lines of tomato: identification of a high antioxidant fruit

line. Phytochemistry, 67(16): 1750-1757.

Luo, X.D., Basile, M.J. and Kennelly, E.J. 2002. Polyphenolic antioxidants from

fruits of Chrysophylolum cainito L. (Star apple). Journal of Agriculture and

Food Chemistry, 50(6): 1379-1382.

Mabberley, D.J. 1990. The Plant Book. Cambridge University Press, London,

pp. 209-289.

Madunagu, B.E., Ebana, R.B., Udo, S.M. and Ndifon, L.T. 2001. Antimicrobial

effects of Ixora divaricata and Citrus aurantifolia on some pathogens and

drug resistant Neisseria gonorrhoeae. Nigerian Journal of Botany, 14: 63-69.

Mahesh, B. and Satish, S. 2008. Antimicrobial activity of some important medicinal

plant against plant and human pathogens. World Journal of Agricultural

Sciences, 4(5): 839-843.

Maheshwari, J.K., Singh, K.K. and Saha, S. 1986. Ethnobotany of tribals of Mirzapur

District, Uttar Pradesh, Economic Botany Information Service, NBRI,

Lucknow, pp. 487-498.

174 �

Maheswaran, R., Kingsley, S. and Ignacimuthu, S. 2008a. Larvicidal and repellent

activity of Clerodendron phlomidis against Culex quinquefasciatus Say

(Diptera: Culicidae), In: Proceedings of Recent Trends in Insect Pest

Management, Elite publications, pp. 240–243.

Maheswaran, R., Sathish, S. and Ignacimuthu, S. 2008b. Larvicidal activity of Leucas

aspera (Willd) against the larvae of Culex quinquefasciatus Say and Aedes

aegypti L. International Journal of Integrative Biology, 2(3): 214–217.

Mai, T.T., Thu, N.N., Tien, P.G. and van Chuyen, N. 2007. Alphaglucosidase

inhibitory and antioxidant activities of Vietnamese edible plants and their

relationships with polyphenol contents. Journal of Nutritional Science and

Vitaminology, 53(3): 267-276.

Majorie, M.C. 1999. Plant products as antimicrobial agents. Clinical Microbiology

Reviews, 12(4): 564-582.

Malar, T.R.J.J., Johnson, M., Mary Uthith, M. and Arthy, A. 2011. Antibacterial

activity of ethanolic extracts of selected medicinal plants against human

pathogens. Asian Pacific Journal of Tropical Biomedicine, 1(1): S76-S78.

Malar, T.R.J.J., Sushna, S.L., Johnson, M., Janakiraman, N. and Ethal, T.R.J.J. 2012.

Bio-efficacy of the leaves extracts of Hyptis suaveolens (L.)Poit against the

fish pathogens. International Journal of Life Science and Pharma Research,

2(1): 128-133.

Malele, R.S., Mutayabarwa, C.K., Mwangi, J.W., Thoithi, G.N., Lopez, A.G., Lucini,

E.I. and Zygadlo, J.A. 2003. Essential oil of Hyptis suaveolens (L.) Poit. from

Tanzania: composition and antifungal activity. Journal of Essential Oil

Research, 15(6): 438-440.

Manchand, P.S., White, J.D., Fayos, J. and Clardy, J. 1974. Chemical constituents of

tropical plants, part IV. Structures of Suaveolic acid and Suaveolol. Journal of

Organic Chemistry, 39 (15): 2306-2308.

Mandal, S.M., Mondal, K.C., Dey, S. and Pati, B.R. 2007. Antimicrobial activity of

the leaf extracts of Hyptis suaveolens (L.) Poit. Indian Journal of

Pharmaceutical Sciences, 69(4): 568-571.

175 �

Mandwal, P.K., Salvekar, V., Patel, R. and Nayak, P.S. 2009. Antioxidant activity of

Hyptis suaveolens whole plant. In: Proceedings of 61st

Indian Pharmaceutical

Congress, Ahmedabad.

Mann, A., Banso, A. and Clifford, L.C. 2008. An antifungal property of crude plant

extracts from Anogeissus leiocarpus and Terminalia avicennioides. Tanzania

Journal of Health Research, 10 (1): 34-38.

Manzocco, L., Anese, M. and Nicoli, M.C. 1998. Antioxidant properties of tea

extracts as affected by processing. Lebensmittel-Wissenschaft und

Technologie, 31(7): 694 – 698.

Marles, R.J. 1996. Prairie Medicinal and Aromatic Plants. Conference-Olds, Food

and Rural Development Publishers, Alberta.

Martins, F.T., Santos, M.H., Pólo, M. and de Barbosa, L.C.A. 2006. Variação química

do óleo essencial de Hyptis suaveolens (L.) Poit. sob condições de cultivo.

Quimica Nova, 29(6): 1203-1209.

Martins, F.T., Santos, M.H., Polo, M. and Barbosa, L.C.A. 2007. Effects of the

interactions among macronutrients, plant age and photoperiod in the

composition of Hyptis suaveolens (L.) Poit essential oil from Alfenas (MG),

Brazil, Flavour and Fragrance Journal, 22(2): 123–129.

Mary, T.R., Anusha, K., Mallaiah, K.V., Ravindranadh, K. and Rao, M.C. 2014.

Phytochemical studies of Hyptis suaveolens (L.) Poit. Journal of Chemical,

Biological and Physical Sciences, 4(1): 319-323.

Masoud, E.A. and Gouda, H.A. 2012. Effect of some natural plant extracts against

gram negative bacteria in Njran Area, Saudi Arabia. Egyptian Academic

Journal of Biological Sciences, 4: 85-92.

Masum, G.Z.H., Dash, B.K., Barman, S.K. and Sen, M.K. 2013. A comprehensive

ethnomedicinal documentation of medicinal plants of Islamic University,

region, Bangladesh. International Journal of Pharmaceutical Sciences and

Research, 4(3): 1202-1209.

Matsui, T., Tanaka, T., Tamura, S., Toshima, A., Miyata, Y., Tanaka, K. and

Matsumoto, K. 2007. �-glucosidase inhibitory profile of catechins and the

aflavins. Journal of Agriculture and Food Chemistry, 55(1): 99–105.

176 �

Mbatchou, V.C., Abdullatif, S. and Glover, R. 2010. Phytochemical screening of

solvent extracts from Hyptis suaveolens LAM for fungal growth inhibition.

Pakistan Journal of Nutrition, 9(4): 358-361.

McConkey, D.J., Zhivotovsky, B. and Orrenius, S. 1996. Apoptosis molecular

mechanisms and biomedical implications. Molecular Aspects of Medicine,

17(1): 1-110.

McDonald, D.M., Mitchell, R.A., Gabella, G. and Haskell, A. 1988. Neurogenic

inflammation in the rat trachea II. Identity and distribution of nerves mediating

the increase in vascular permeability. Journal of Neurocytology, 17(5):

605-628.

Mclarty, J.W. 1997. Antioxidants and cancer, the epidemiologic evidence.

In: Garewal, H.S. (ed.), Antioxidants and Disease Prevention. CRC Press,

New York, pp. 45-66.

McNeil, M., Facey, P. and Porter, R. 2011. Essential oil from the Hyptis genus- a

review. Natural Product Communications, 6(11): 1775-96.

Meiri, D., Tazat, K., Cohen-Peer, R., Farchi-Pisanty, O., Aviezer-Hagai, K., Avni, A.

and Breiman, A. 2010. Involvement of Arabidopsis ROF2 (FKBP65) in

thermotolerance. Plant Molecular Biology, 72(1-2): 191-203.

Menichini, F., Conforti, F., Rigano, D., Formisano, C., Piozzi, F. and Senatore, F.

2009. Phytochemical composition, anti-inflammatory and cytotoxic activities

of four Teucrium essential oils from Greece. Food Chemistry, 115(2):

679-686.

Metcalfe, C.R. and Chalk, L. 1950. Anatomy of Dicotyledons. Vol.II. Clarendon

Press, Oxford University Press, London, p. 1500.

Middleton, E.J., Kandaswami, C. and Theoharides, T.C. 2000. The effects of plant

flavonoids on mammalian cells: implications for inflammation, heart disease

and cancer. Pharmacological Reviews, 52(4): 673-751.

Miller, G.L. 1959. Use of dinitro salicylic acid reagent for determination of reducing

sugar. Analytical Chemistry, 31(3): 426-428.

177 �

Miller, B.R., Godsey, M.S., Crabtree, M.B., Savage, H.M., Al-Mazrao, Y., Al-Jeffri,

M.H., Abdoon, A.M., Al-Seghayer, S.M., Al-Shahrani, A.M. and

Ksiazek, T.G. 2002. Isolation and genetic characterization of Rift valley fever

virus from Aedes vexans arabiensis, kingdom of Saudi Arabia. Emergence of

Infectious Diseases, 8(12): 1492-1494.

Miller, L.K. 1999. An exegesis of IAPs: salvation and surprises from BIR motifs.

Trends in Cell Biology, 9(8): 323-328.

Misra, T.N., Singh, R.S. and Upadhyay, J. 1983a. A natural triterpene acid from

Hyptis suaveolens roots. Phytochemistry, 22(11): 2557-2558.

Misra, T.N., Singh, R.S. and Upadhyay, J. 1983b. Triterpenoids of Hyptis suaveolens

roots. Phytochemistry, 22(2): 603-605.

Mogale, M.A., Lebelo, S.L., Thovhogi, N., de Freitas, A.N. and Shai. L.J. 2011. �-

Amylase and �-glucosidase inhibitory effects of Sclerocarya birrea

[(A. Rich.)Hochst.] sub species caffra (Sond) Kokwaro (Anacardiaceae) stem-

bark extracts. African Journal of Biotechnology, 10(66): 15033-15039.

Montalleb, G., Hanachi, P., Kua, S.H., Fauziah, O. and Asmah, R. 2005. Evaluation

of phenolic content and total antioxidant activity in Berberis vulgaris fruit

extract. Journal of Biological Sciences, 5(5): 648-653.

Moreira, A.C.P., de Oliveira, L.E., Wanderley, P.A., Carmo, E.S. and de Souza, E.L.

2010. Chemical composition and antifungal activity of Hyptis suaveolens (L.)

Poit. leaves essential oil against Aspergillus species. Brazilian Journal of

Microbiology, 41: 28-33.

Mosmann, T. 1983. Rapid colorimetric assay for cellular growth and survival:

application to proliferation and cytotoxicity assays. Journal of Immunological

Methods, 65(1): 55-63.

Mukherjee, K.S., Mukherjee, R.K. and Ghosh, P.K. 1984. Chemistry of

Hyptis suaveolens: a pentacyclic triterpene. Journal of Natural Products,

47(2): 377-378.

Mukherjee, D., Nissen, S.E. and Topol, E.J. 2001. Risk of cardiovascular events

associated with selective COX-2 inhibitors. Journal of American Medical

Association, 286(8): 954-959.

178 �

Murray, B.E. 1992. Problems and dilemmas of antimicrobial resistance.

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy,

12(6P2): 86S-89S.

Musa, A.K., Dike, M.C. and Onu, I. 2009. Evaluation of Nitta (Hyptis suaveolens

Poit.) seed and leaf extracts and seed powder for the control of Trogoderma

granarium Everts (Coleoptera: Dermestidae) in stored groundnut. American-

Eurasian Journal of Agronomy, 2(3): 176-179.

Musika, S. and Indrapichate, K. 2014. Cytotoxicity and apoptotic induction of

mintweed (Hyptis suaveolens L. Poit.) leaf extracts on human T-Leukemia cell

line, Jurkat cells. World Journal of Pharmacy and Pharmaceutical Sciences,

3(3): 304-317.

Muthukumaran, P., Shanmuganathan, P. and Malathi, C. 2011. In vitro antioxidant

evaluation of Mimosa pudica. Asian Journal of Pharmaceutical Research,

2: 44-46.

Myers, N., Mittermeier, R.A., Mittermeier, C.G., daFonseca, G.A.B. and Kent, J.

2000. Biodiversity hotspots for conservation priorities. Nature, 403(6772):

853–858.

Nabavi, S.F., Nabavi, S.M., Hellio, C., Alinezhad, H., Zare, M., Azimi, R. and

Baharfar, R. 2012. Antioxidant and antihemolytic activities of methanol

extract of Hyssopus angustifolius. Journal of Applied Botany and Food

Quality, 85(2): 198.

Nagarajan, N.S., Murugesh, N., Thirupathy, K.P., Radha, N. and Murali, A. 2005.

Antidiabetic and antihyhyperlipidemic effects of Cleomeo felina. Fitoterapia,

76: 310-315.

Naim, M., Gestetner, B., Bondi, A. and Birk, Y. 1976. Antioxidative and

antihaemolytic activity of soybean isoflavones. Journal of Agricultural and

Food Chemistry, 24(6): 1174-1177.

Nair, R. and Sumitra, V.C. 2007. Antibacterial activities of some medicinal plants of

the western region of India. Turkish Journal of Biology, 31(4): 231-236.

179 �

Nantitanon, W., Chowwanapoonpohn, S. and Okonogi, S. 2007. Antioxidant and

antimicrobial activities of Hyptis suaveolens essential oil. Scientia

Pharmaceutica, 75(1): 35-46.

Naruthapata, C. and Supaporn, S. 2009. Antioxidant and radical scavenging activity

of herbal medicine samples. In: International Conference on Pure and Applied

Chemistry, John Wiley & Sons, New Jersey, pp. 42-44.

Nayak, P.S., Kar, D.M. and Nayak, S. 2013. Evaluation of antidiabetic and

antioxidant activity of aerial parts of Hyptis suaveolens Poit. African Journal

of Pharmacy and Pharmacology, 7(1): 1-7.

Nayak, P.S., Nayak, S., Kar, D.M. and Das, P. 2010. In vitro anthelmintic activity of

whole plant extracts of Hyptis suaveolens Poit. International Journal of

Current Pharmaceutical Research, 2(2): 50-51.

Nayar, M.P. 1996. Hotspots of Endemic Plants of India, Nepal and Bhutan,

Thiruvananthapuram. Tropical Botanical Garden Research Institute. Vedams

eBooks, New Delhi, India, p. 252.

Newman, D.J., Cragg, G.M. and Snader, K.M. 2003. Natural products as sources of

new drugs over the period 1981-2002. Journal of Natural Products, 66(7):

1022-1037.

Niki, E. 1982. Antioxidants in relation to lipid peroxidation. Chemical Physical

Lipids, 44(2): 227-253.

Nipun, D., Vijay, S., Jaykumar, B., Kirti, S.P. and Richard, L. 2011. Antitumor

activity of Dendrophthoe falcata against Ehrlich ascites carcinoma in swiss

albino mice. Pharmaceutical Crops, 2: 1-7.

Notkins, A.L. 2002. Immunologic and genetic factors in type 1 diabetes. Journal of

Biological Chemistry, 277(46): 43545-43548.

Noudogbessi, J.P., Alitonou, G.A., Djènontin, T., Avlessi, F., Figueredo, G., Chalard,

P. and Sohounhloue, D.C.K. 2013. Chemical compositions and physico-

chemical properties of three varieties essential oils of Cymbopogon giganteus

growing to the spontaneous state in Benin. Oriental Journal of Chemistry,

29(1): 59-67.

180 �

O’Brien, T.P., Feder, N. and Mc Cull, M.E. 1964. Polychromatic staining of plant cell

walls by toluidine blue-O. Protoplasma, 59(2): 368-373.

Odugbemi, T.O., Akinsulire, O.R., Aibinu, I.E. and Fabeku, P.O. 2007. Medicinal

plants useful for malaria therapy in Okeigbo Ondo state, southwest Nigeria.

African Journal of Traditional, Complementary and Alternative Medicines,

4 (2): 191-198.

Ogundipe, O., Akinbiyi, O. and Moody, J.O. 1998. Antibacterial activities of essential

ornamental plants. Nigerian Journal of Natural Products and Medicine,

2: 46-47.

Okigbo, R.N., Agbata, C.A. and Echezona, C.E. 2010. Effect of leaf extract of

Azadirachta indica and Chromolaena odorata on post harvest spoilage fungi

of yams in storage. Current Research Journal of Soil Sciences, 2(1): 9-12.

Okonogi, S., Chansakaow, S., Vejabhikul, S., Tharavichitkul, P., Lerphokanont, J.,

Nakano, A. and Ikegami, F. 2005. Antimicrobial activity and pharmaceutical

development of essential oil from Hyptis suaveolens. Acta Horticulturae, 678:

163-169.

Okoye, E.I. and Chukwu, P.I. 2014. Extraction and preliminary structural elucidation

of alkaloid and flavonoid in Hyptis suaveolens. Peak Journal of Medicinal

Plant Research, 2 (4): 45-49.

Oliver-Bever, B. 1960. Nigeria’s useful plants, Part II. Medicinal plants. Nigerian

Field, 25 (1): 46-48.

Oliver-Bever, B. 1986. Medicinal Plants in Tropical West Africa, Cambridge

University Press, London, p. 225.

Omoyeni, O.A., Aterigbade, E., Akinyeye, R.O. and Olowu, R.A. 2012.

Phytochemical screening, nutritional/antinutritional and aminoacid

compositions of Nigeria Melanthera scandens. Scientific Reviews and

Chemical Communications, 2(1): 20-30.

Onwuliri, F.C. and Dawang, N.D. 2006. Antibacterial activity of aqueous and

ethanolic leaf extract of drumstick plant (Moringa oleifera Lam.) on some

bacterial species associated with gastrointestinal diseases. Nigerian Journal of

Botany, 19(2): 272-279.

181 �

Onyeke, C.C., Ajuziogu, G.C., Osayi, E.E., Nwani, C.D. and Odo, G.E. 2014.

Efficacy of soil amendment with leaf powder of Hyptis suaveolens (L.) Poit. in

the control of Meloidogyne javanica (Treub) Chitwood on the African Yam

bean, Sphenostylis stenocarpa (Hochst ex A. Rich) Harms. Plant Pathology

Journal, 13 (2): 112-119.

Oyedemi, S.O. and Afolayan, A.J. 2011. Antibacterial and antioxidant activities of

hydroalcoholic stem bark extract of Schotia latifolia Jacq. Asian Pacific

Journal of Tropical Medicine, 4(12): 952-958.

Pachkore, G.L. and Dhale, D.A. 2011. Pharmacognostic evaluation of Hyptis

suaveolens (L. Poit.) Lamiaceae. Journal of Ecobiotechnology, 3(3): 5-10.

Pachkore, G.L., Dhale, D.A. and Dharasurkar, A.N. 2011. Antimicrobial

and phytochemical screening of Hyptis suaveolens (L. Poit.) Lamiaceae,

International Multidisciplinary Research Journal, 1(4): 01-03.

Panchal, R.G. 1998. Novel therapeutic strategies to selectively kill cancer cells.

Biochemical Pharmacology, 55(3): 247-252.

Panda, S.K., Thatoi, H.N. and Dutta, S.K. 2009. Antibacterial activity and

phytochemical screening of leaf and bark extracts of Vitex negundo L. from

Simlipal biosphere reserve, Orissa. Journal of Medicinal Plants Research,

3(4): 294-300.

Pankaj, 2005. http//www.celestine.india.com/hyptissuaveolens

Pant, A.K., Singh, A.K., Mathela, C.S., Parihar, R., Dev, V., Nerio, A.T. and Bottini,

A.T. 1992. Essential oil from Hyptis suaveolens Poit. Journal of Essential Oil

Research, 4(1): 9-13.

Parasuraman, S., Raveendran, R. and Madhavrao, C. 2009. GC-MS analysis of leaf

extracts of Cleistanthus collinus Roxb. (Euphorbiaceae). International Journal

of Pharmaceutical Sciences, 1(2): 284-286.

Parichad, L. and Krittaporn, N.N. 1990. Chemical constituents of Hyptis suaveolens

Poit. leaves. Natural Products Research Unit. Available online at

http://www.sc.chula.ac.th/department/chemistry/npru/SENIOR%20PROJECT.

htm.

182 �

Parr, A. and Bolwell, G.P. 2000. Phenols in the plant and in man: the potential for

possible nutritional enhancement of the diet by modifying the phenols content

or profile. Journal of the Science of Food and Agriculture, 80(7): 985-1012.

Parsons, W.T. and Cuthbertson, E.G. 2001. Noxious weeds of Australia. CSIRO

Publishing, Collingwood, p. 698.

Paschka, A.G., Butler, R. and Young, C.Y. 1998. Induction of apoptosis in prostate

cancer cell lines by the green tea component, epigallocatechin-3- Gallate.

Cancer Letters, 130(1): 1-7.

Patil, B.J. and Madane, A.N. 2014. Effect of H. suaveolens (L.) Poit. and Eupatorium

odoratum L. leaf extracts on seed mycoflora of legume plants. Bioscience

Discovery, 5(2): 237-240.

Raj, K.P., Irudayaraj, V., Johnson, M. and Raja, D.P. 2011. Phytochemical and

anti-bacterial activity of epidermal glands extract of Christella parasitica (L.)

H. Lev. Asian Pacific Journal of Tropical Biomedicine, 1(1): 8-11.

Paz, E.A., Cerdeiras, M.P. and Fernandez, F. 1995. Screening of Uruguayan

medicinal plants for antimicrobial activity. Journal of Ethnopharmacology,

45(1): 67-70.

Peerzada, N. 1997. Chemical composition of the essential oil of Hyptis suaveolens.

Molecules, 2(11): 165-168.

Perandones, C.E., Iiiera, V.A., Peckham, D. and Stunz, L.L. 1993. Regulation of

apoptosis in vitro in mature spleen T-cell. The Journal of Immunology, 151(7):

3521-3528.

Pezutto, J.M. 1997. Plant-derived anticancer agents. Biochemical Pharmacology,

53(2): 121-133.

Pietta, P.G. 1998. Flavonoids in medicinal plants. In: Rice-Evans, C.A. and Packer, L.

(eds.), Flavonoids in Health and Disease. NewYork, Dekker, pp. 61-110.

Pietta, P.G. 2000. Flavonoids as antioxidant. Journal of Natural Products, 63(7):

1035-1042.

183 �

Pistelli, L. 2006. Phytochemicals from Lamiaceae: From Nutraceutics to

Hallucinogens. International Symposium on the Labiatae: Advances in

Production, Biotechnology and Utilization, Sanremo, Italy, p. 2.

Policegoudra, R.S., Abiraj, K., Gowda, D.C. and Aradhya, S.M. 2007. Isolation and

characterization of antioxidant and antibacterial compound from mango ginger

(Curcuma amada Roxb.) rhizome. Journal of Chromatography B Analytical

Technologies in the Biomedical and Life Sciences, 852(1): 40-48.

Prabakar, K. and Jebanesan, A. 2004. Larvicidal efficacy of some Cucurbitacious

plant leaf extracts against Culex quinquefasciatus (Say). Bioresource

Technology, 95(1): 113–114.

Prasanna, S.R. and Koppula, S.B. 2012. Antimicrobial and preliminary phytochemical

analysis of solvent extracts of Hyptis suaveolens from banks of river Krishna.

International Journal of Bio-Pharma Research, 1(1): 11-15.

Pratt, D.E. 1992. Natural anti-oxidants from plant material in phenolic compounds in

food and their effects on health, In: Hang, M., Ho, C. and Lee, C. Antioxidants

and cancer prevention (Acs symposium series 507), (ed.), American Chemical

Society, Washington DC, p. 54.

Priyadharshini, S.D. and Sujatha, V. 2013. Antioxidant and cytotoxic studies on two

known compounds isolated from Hyptis suaveolens leaves. International

Journal of Pharmacy and Pharmaceutical Sciences, 5(4): 283-290.

Puls, W., Keup, U., Krause, H.P., Thomas, G. and Hoffmeister, F. 1997. Glucosidase

inhibition. Naturwissenschaften, 64(10): 536-537.

Rabe, T. and van Stoden, J. 2000. Isolation of an antimicrobial sesquiterpenoid from

Warbugie salutaris. Journal of Pharmacology, 93: 171-174.

Radford, I.R., Murphy, T.K., Radley, J.M. and Ellis, S.L. 1994. Radiation response of

mouse lymphoid and myeloid cell lines Part II. apoptotic death is shown by all

lines examined. International Journal of Radiation Biology, 65(2):

217-227.

184 �

Rai, I., Bachheti, R.K., Joshi, A. and Pandey, D.P. 2013. Physicochemical properties

and elemental analysis of some non cultivated seed oils collected from

Garhwal region, Uttarkhand (India). International Journal of Chem Tech

Research, 5(1): 232-236.

Raja, R.D.A., Prakash, J.W. and Jeeva, S. 2010. Antibacterial activity of some

medicinal plants used by Kani tribe, southern Western Ghats, Tamilnadu,

India. In: Trivedi, P.C. Ethnic tribes and medicinal plants. Pointer Publishers,

Jaipur, pp. 28-45.

Raja, R.D.A., Jeeva, S., Prakash, J.W., Johnson, M. and Irudayaraj, V. 2011.

Antibacterial activity of selected ethnomedicinal plants from South India.

Asian Pacific Journal of Tropical Medicine, 4(5): 375-378.

Rajarajan, P.N., Rajasekaran, K.M. and Asha Devi, N.K. 2014. Antifungal and

phytochemical screening of Hyptis suaveolens (L.) Poit. Lamiaceae on

aflatoxin producing fungi. Scholars Academic Journal of Pharmacy,

3(1): 50-52.

Rajeswari, G., Murugan, M. and Mohan, V.R. 2013. GC-MS analysis of bioactive

components of Hugonia mystax L. bark (Linaceae). Journal of

Pharmaceutical and Biomedical Sciences, 29(29): 818-824.

Ranilla, L.G., Kwon, Y.I., Apostolidis, E. and Shetty, K. 2010. Phenolic compounds,

antioxidant activity and in vitro inhibitory potential against key enzymes

relevant for hyperglycemia and hypertension of commonly used medicinal

plants, herbs and spices in Latin America. Bioresource Technology, 101(12):

4676-4689.

Rao, K.V.R., Rao, L.J.M. and Rao, N.S.P. 1990. An A-ring contracted triterpenoid

from Hyptis suaveolens. Phytochemistry, 29(4): 1326-1329.

Re, R., Pellegrini, N., Proteggente, A., Pannala, A., Yang, M. and Rice-Evans, C.

1999. Antioxidant activity applying an improved ABTS radical cation

decolorization assay. Free Radical Biology and Medicine, 26(9): 1231–1237.

Rice-Evans, C.A., Miller, J.M. and Paganga, G. 1996. Structure-antioxidant activity

relationship of flavonoids and phenolic acids. Free Radical Biology and

Medicine, 20(7): 933-956.

185 �

Riss, T.L. and Moravec, R.A. 2004. Use of multiple assay endpoints to investigate the

effects of incubation time, dose of toxin, and plating density in cell-based

cytotoxicity assays. Assay and Drug Development Technologies, 2(1): 51-62.

Robak, J. and Gryglewski, R.J. 1988. Flavonoids are scavengers of superoxide anions.

Biochemical Pharmacology, 37(5): 837-841.

Robert, E.B. 1971. Method for estimation of tannin in grain sorghum. Agronomy

Journal, 63(3): 511-512.

Rodgers, W.A. and Panwar, H.S. 1990. A Biogeographical Classification for

Conservation Planning. Wildlife Institute of India, Dehradun, India, p. 370.

Rojas, R., Bustmante, B. and Bauer, J. 2003. Antimicrobial activity of selected

Peruvian medicinal plants. Journal of Ethnopharmacology, 88(2): 199-204.

Rudal, P. 1980. Leaf anatomy of the subtribe Hyptidinae of Labiatae. Botanical

Journal of Linnean Society, 80(4): 319-340.

Russell, W.R., Baka, A., Bjorck, I., Delzenne, N., Gao, D., Griffiths, H.R.,

Hadjilucas, E., Juvonen, K., Lahtinen, S., Lansink, M., van Loon, L.,

Mykkanen, H., Ostman, E., Riccardi, G., Vinov, S. and Weickert, M.O. 2013.

Impact of diet composition on blood glucose regulation. Critical Reviews in

Food Science and Nutrition, doi: 10.1080/10408398.2013.792772.

Saify, Z.S., Farhad, J., Mushtaq, N., Noor, F., Akhtar, S., Arif, M., Naqvi, B.S. and

Shoaib, M.H. 2005. Antibacterial activity of 1-methyl-7-methoxy-�-carboline

and its phenacyl and coumarine analogues. Pakistan Journal of

Pharmaceutical Sciences, 18(3): 39−41.

Sainani, G.S., Manik, J.S. and Sainani, R.G. 1997. Oxidative stress: A key factor in

pathogenesis of chronic diseases. Med Update, 1: 1.

Sajeesh, T., Arunachalam, K. and Parimelazhagan, T. 2011. Antioxidant and

antipyretic studies on Pothos scandens L. Asian Pacific Journal of Tropical

Medicine, 4(11): 889-899.

Sales, P.M., Souza, P.M., Simeoni, L.A. and Silveira, D. 2012. �-Amylase inhibitors:

a review of raw material and isolated compounds from plant source. Journal

of Pharmacy and Pharmaceutical Sciences, 15(1): 141-183.

186 �

Salie, F., Eagles, P.F.K. and Leng, H.M.J. 1996. Preliminary screening of four South

African Asteraceae species. Journal of Ethnopharmacology, 52(1): 27-33.

Saluja, A.K., Santani, D.D. and Singh, J.D. 1981. A short note on chemical

constituents of Hyptis suaveolens Poit. Indian Drugs, 19: 84.

Saluja, A.K. and Santani, D.D. 1984. Chemical studies of Hyptis suaveolens Poit.

Indian Drugs, 21 (10): 423-424.

Samrot, A.V., Mattew, A.A. and Largus, S. 2010. Evaluation of bioactivity of various

Indian medicinal plants-an In vitro study. Internet Journal of Internal

Medicine, 8(2): DOI: 10.5580/de.

Santos, T.C., Marques, M.S., Menezes, I.A.C., Dias, K.S., Silva, A.B.L. and Mello,

I.C.M. 2007. Antinociceptive effect and acute toxicity of the Hyptis

suaveolens leaves aqueous extract on mice. Fitoterapia, 78(5): 333-336.

Sass, J.E. 1940. Elements of Botanical Microtechnique. Mc Graw Hill Book Co,

Newyork, p. 222.

Sastri, B.N. 1959. Wealth of India, Vol. V (H-K), Council of Scientific and Industrial

Research, New Delhi, pp. 75-98.

Sastry, V.M.V.S. and Rao, G.R.K. 1994. Antibacterial substances from marine algae:

successive extraction using benzene, chloroform and methanol. Botanica

Marina, 37(4): 357-360.

Sathishkumar, P.S. and Paulsamy, A.M. 2009. Effect of habitat variation on the

content of certain secondary metabolites of medicinal importance in the

leaves of the plant, Acacia caesia Wild. Journal of Advanced Plant Sciences,

22(11): 451-453.

Satish, A.P., Paresh, U.P. and Natavarlal, J.P. 2011. Absorbance correction method

for simultaneous determination of nebivolol and amlodipine besylate in

combined tablet dosage form. International Research Journal of Pharmacy,

2 (8): 92-95.

Satish, V., Ravichandrian, V.D., Gavani, U. and Paarakh, P. 2010. Antimicrobial

studies on the extracts of Cocculus hirsutus Linn. and Hyptis suaveolens Poit.

Indian Journal of Natural Products Resources, 1: 49-52.

187 �

Saxena, A. and Vikram, N.K. 2004. Role of selected Indian plants in management of

type 2 diabetes: A review. The Journal of Alternative and Complementary

Medicine, 10(2): 369-378.

Scott, L.J. and Spencer, C.M. 2000. Miglitol: a review of its therapeutic potential in

type 2 diabetes mellitus. Drugs, 59(3): 521-549.

Sengupta, A., Ghosh, S. and Bhattacharjee, S. 2004. Allium vegetables in

cancer prevention: an overview. Asian Pacific Journal of Cancer Prevention,

5(3): 237-245.

Senthilkumar, P.K. and Reetha, D. 2009. Screening of antimicrobial properties of

certain Indian medicinal plants. Journal of Phytology, 1(3): 193-198.

Shaalan, E.A.S., Canyon, D., Younes, M.W.F., Abdel-Wahab, H. and Mansour, A.H.

2005. A review of botanical phytochemicals with mosquitocidal potential.

Environment International, 31(8): 1149-1166.

Shaikat, Z.H., Hossain, T. and Azam, G. 2014. Phytochemical screening and

antidiarrhoeal activity of Hyptis suaveolens. International Journal of Applied

Research in Natural Products, 5 (2): 1-4.

Shaikh, J., Uddin, I., Darren, G. and Evelin, T. 2011. Cytotoxic effects of Bangladeshi

medicinal plant extracts. Evidence Based Complementary and Alternative

Medicine, 2011: 1-7.

Shale, T.L., Strik, W.A. and Sladen, V.J. 1999. Screening of plants used by southern

African traditional healers in the treatment of dysmenorrhoea for

prostaglandin systhesis inhibitors and uterine releasing activity. Journal of

Ethnopharmacology, 64(1): 9-14.

Shan, B., Cai, Y.Z., Sun, M. and Corke, H. 2005. Antioxidant capacity of 26 spice

extracts and characterization of their phenolic constituents. Journal of the

Agricultural and Food Chemistry, 53(20): 7749–7759.

188 �

Sharma, N., Verma, U.K. and Tripathi, A. 2007. Bioactivity of essential oil from

Hyptis suaveolens against storage mycoflora. In: Donahaye, E.J., Navarro, S.,

Bell, C., Jayas, D., Noyes, R. and Phillips, T.W. (eds.). Proceedings of

International Conference on Controlled Atmosphere and Fumigation in Stored

Product, Gold-Coast Australia, 8-13th August 2004. FTIC Ltd. Publishing,

Israel, pp. 99-116.

Sharma, N. and Tripathi, A. 2008. Integrated management of postharvest Fusarium rot

of gladiolus corms using hot water, UV-C and Hyptis suaveolens (L.) Poit.

essential oil. Postharvest Biology and Technology, 47(2): 246–254.

Shenoy, C., Patil, M.B. and Kumar, R. 2009. Wound healing activity of Hyptis

suaveolens L.) Poit. International Journal of PharmTech Research,

1(3): 737-744.

Shirwaikar, A., Radhika, S., Udupa, A.L., Udupa, S.L. and Somashekar, S. 2003.

Wound healing property of ethanolic extract of leaves of Hyptis suaveolens

with supportive role of antioxidant enzymes. Indian Journal of Experimental

Biology, 41(3): 238-241.

Shoba, F.G. and Thomas, M. 2001. Study of antidiarrhoel activity of four medicinal

plants in castor oil induced diarrhoea. Journal of Ethnopharmacology,

76(1): 73-76.

Shreejayan, D. and Rao. N.A. 1997. Nitric oxide scavenging by curcuminoids.

Journal of Pharmacy and Pharmacology, 49(1): 105-107.

Sidibe, L., Chalchat, J.C., Garri, R.P. and Harama, M. 2001. Aromatic plants of Mali

(III): chemical composition of essential oils of two Hyptis species:

H. suaveolens (L.) Poit. and H. spicigera Lam. Journal of Essential Oil

Research, 13(1): 55-57.

Sikkema, J., de Bont, J.A.M. and Poolman, B. 1994. Interactions of cyclic

hydrocarbons with biological membranes. Journal of Biological Chemistry,

269(11): 8022-8028.

Singh, N.P. and Chowdhery, H.J. 2002. Biodiversity conservation in India, In: Das,

A.P. (ed.), Perspective of Plant Biodiversity. Department of Botany, North

Bengal University, West Bengal, India. pp. 501-527.

189 �

Singh, R., Singh, S., Kumar, S. and Arora, S. 2007. Studies on antioxidant potential of

methanol extract/fractions of Acacia auriculiformis A.Cunn. Food Chemistry,

103(2): 505-511.

Small, E. and Catling, P.M. 1999. Canadian Medicinal Crops. NRC Research Press,

Ottawa, Ontario, Canada p. 240.

Smets, L.A. 1994. Programmed cell death (apoptosis) and response to anticancer

Drugs. Anticancer Drugs, 5(1): 3- 9.

Solai, R.P., Preeth, M. and Shobana, J. 2010. In vitro anti-oxidant activity of the

various extracts of Tribules terestris leaves by UV Spectrophotometer.

International Journal of Research in Pharmaceutical and Biomedical

Sciences, 1 (2): 152-155.

Soobrattee, M.A., Neergheen, V.S., Luximon-Ramma, A., Aruoma, O.I. and Bahorun,

T. 2005. Phenolics as potential antioxidant therapeutic agents: mechanism and

actions. Mutation Research/Fundamental and Molecular Mechanisms of

Mutagenesis, 579(1): 200 – 213.

Sreejayan, M. and Rao, M.N. 1996. Free radical scavenging activity of curcuminoids.

Arzneimittelforschung, 46(2): 169-171.

Stief, T.W. 2003. The physiology and pharmacology of singlet oxygen. Medical

Hypotheses, 60(4): 567- 572.

Sudha, P., Zinjarde, S.S., Bhargava, Y.S. and Kumar, R.A. 2011. Potent �-amylase

inhibitory activity of Indian ayurvedic medicinal plants. BMC Complementary

and Alternative Medicine, 11(1): 1-10.

Sukumar, K., Perich, M.J. and Boobar, L.R. 1991. Botanical derivatives in mosquito

control: a review. Journal of American Mosquito Control Association,

7(2): 210-137.

Sulta, H., Ali, J. and Annamalai, K. 2013. Comparative phytochemical and nutritional

studies of leaves of three different localities of Hyptis suaveolens (L). Poit,

Lamiaceae members. International Journal of Current Molecular Research,

1(1): 16-17.

190 �

Sun, J., Chu, Y.F. and Wu, X.Z. 2002. Antioxidant and antiproliferative activities

of common fruits. Journal of Agriculture and Food Chemistry, 50(25):

7449-7454.

Sun, L., Hui, A.M., Su, Q., Vortmeyer, A., Kotliarov, Y., Pastorino, S. and Fine, H.A.

2006. Neuronal and glioma-derived stem cell factor induces angiogenesis

within the brain. Cancer Cell, 9(4): 287-300.

Syamasundar, K.V., Vinodh, G., Srikanth, S. and Balakishan, B. 2012. Variations in

volatile oil compositions of different wild collections of Hyptis suaveolens

(L.) Poit from Western Ghats of India. Journal of Pharmacognosy,

3(2): 131-135.

Tachakittirungrod, S. Okonogi, S. and Chowwanapoonpohn, S. 2007. Study on

antioxidant activity of certain plants in Thailand: mechanism of antioxidant

action of guava leaf extract. Food Chemistry, 103(2): 381–388.

Tahir, S.S., Khenam, M. and Husain, S.Z. 1995. A micromorphological study of

Pogostemon Desf. species (Lamiaceae) from Bangladesh. Pakistan Journal of

Botany, 27(1): 73-82.

Tapsell, L.C., Hemphill, I. and Cobiac, L. 2006. Health benefits of herbs and spices;

the past, the present, the future. Medical Journal of Australia, 185(4): S4-24.

Taylor, J.L.S., Rabe, T., Megano, L.J., Jager, A.K. and van Slaten, J. 2001. Towards

the scientific validation of traditional medicinal plants. Plants Growth

Regulator, 34(1): 23-37.

Teixeira, B., Marques, A., Ramos, C., Neny, N.R., Nogueira, J.M.F., Saraiva, J.A. and

Nunes, M.L. 2013. Chemical composition and antibacterial and antioxidant

properties of commercial essential oils. Industrial Crops and Products,

43: 587-595.

Telford, W.G., King, L.E. and Fraker, P.J. 1991. Evaluation of glucocorticoid-induced

DNA fragmentation in mouse thymocytes by flow cytometry. Cell

Proliferation, 24(5): 447-459.

Thambiraj, J. and Paulsamy, S. 2012. Rapid in vitro multiplication of the

ethnomedicinal shrub, Acacia caesia (L.) Willd. (Mimosaceae) from leaf

explants. Asian Pacific Journal of Tropical Biomedicine, 2(2): S618–S622.

191 �

Thornes, R.D. 1997. Clinical and biological observations associated with coumarins,

In: Kennedy, R.O. and Thornes, R.D. (eds.), Coumarins: biology, applications

and mode of action. John Wiley & Sons, Inc., New York, p. 256.

Tonk, S., Bartarya, R., Kumari, K.M., Bhatnagar, V.P. and Srivastava, S.S. 2006.

Effective method for extraction of larvicidal component from leaves of

Azadirachta indica and Artemisia annua Linn. Journal of Environmental

Biology, 27(1): 103-105.

Topçu, G., Tümen, G., Kılıç, T., Gören, A.C., Barla, A., Türkmen, Z. and Kingston,

D.G.I. 2009. Bioactive Turkish plant extracts and their constituents.

In: Sener, B. (ed.), Innovations in Chemical Biology, Springer Science,

doi: 10. 1007/978-1-4020-6955-0. pp. 61-81.

Towers, G.H., Lopez, A. and Hudson, J.B. 2001. Antiviral and antimicrobial activities

of medicinal plants. Journal of Ethnopharmacology, 77: 189-196.

Tsao, R. and Deng, Z. 2004. Separation procedures for naturally occurring antioxidant

phytochemicals. Journal of Chromatography B, 812(1): 85-99.

Udaykumar, P. 2005. Textbook of Medical Pharmacology, CBS Publishers,

New Delhi, p. 317.

Udhayakala, P., Rajendiran, T.V., Seshadri, S. and Gunasekaran, S. 2011. Quantum

chemical vibrational study, molecular property and HOMO-LUMO energies

of 3-bromoacetophenone for Pharmaceutical application. Journal of Chemical

and Pharmaceutical Research, 3(3): 610-625.

Umedum, N.L., Udeozo, I.P., Muoneme, O., Okoye, N. and Iloamaeke, I. 2013.

Proximate analysis and mineral content of three commonly used seasonings in

Nigeria. IOSR Journal of Environmental Science, Toxicology and Food

Technology, 5(1): 11-14.

Uzama, D., Ikoko, P.P., Fagbohun, A. and Rabiu, L.D. 2013. GC-MS analysis of

Hyptis suaveolens essential oil. International Journal of Natural Product

Science, 3(3): 21-24.

Vahabi, K., Mansoori, G. and Karimi, V. 2011. Biosynthesis of silver nanoparticles

by fungus Trichoderma reesei. Insciences Journal, 1(1): 65-79.

192 �

van Hac, L., Khoi, T.T., Dung, N.X., Mardarowicz, M. and Leclercq, P.A. 1996.

A new chemotype of Hyptis suaveolens (L.) Poit. from the Nghe an province,

Vietnam. Journal of Essential Oil Research, 8(3): 315-318.

van Seters, 1995. A remedial treasure in our tropical timberyard? Medicine and

Global Survival, 2(4): 248-251.

van Wyk, B., Gericke, N. and van Oudtshoorn, B. 2000. Medicinal Plants of South

Africa. Briza Publications. Pretoria, South Africa, pp. 304-312.

Velioglu, Y.S., Mazza, G. and Gao, L. 1998. Antioxidant activity and total phenolics

in selected fruits, vegetables and grain products. Journal of Agriculture and

Food Chemistry, 46(10): 4113-4117.

Vera-Arzave, C., Antonio, L.C., Arrieta, J., Cruz-Hernández, G., Velázquez-Méndez,

A.M., Reyes-Ramírez, A. and Sánchez-Mendoza, M.E. 2012. Gastroprotection

of suaveolol, isolated from Hyptis suaveolens, against ethanol-induced gastric

lesions in wistar rats: role of prostaglandins, nitric oxide and sulfhydryls.

Molecules, 17(8): 8917-8927.

Verma, L., Khatri, A., Kaushik, B., Patil, K.U. and Pawar, S.R. 2010. Antidiabetic

activity of Cassia occidentalis (Linn.) in normal and alloxan induced diabetic

rats. Indian Journal of Pharmacology, 42(4): 224-228.

Vijayabaskaran, M., Babu, G. and Venkateswaramurthy, N. 2010. In vitro antioxidant

potential of ethanolic bark extract of Symplocos racemosa Roxb. International

Journal of Pharmaceutical Technology, 2(3): 320- 326.

Vinay, R.P., Prakash, R.P. and Sushil, S.K. 2010. Antioxidant activity of some

selected medicinal plants in western region of India. Advanced Biology

Research, 4(1): 23-26.

Vinayak, R.C., Sabu, A.S. and Anil, C. 2010. Bio-evaluation of two red seaweeds for

their cytotoxic and antioxidant activities in vitro. Journal of Complementary

and Integrative Medicine, 7(1): 42-45.

Visioli, F., Keaney, J.F. and Halliwell, B. 2000. Antioxidants and cardiovascular

disease; pancreas or tonics for tired sheep. Cardiovascular Research,

47: 409-418.

193 �

Vlietinck, A.J., van Hoof, L. and Totte, J. 1995. Screening of hundred Rwandese

medicinal plants for antimicrobial and antiviral properties. Journal of

Ethnopharmacology, 46(1): 31-47.

Wang, H., Cao, G. and Prior, R.L. 1997. Oxygen radical absorbing capacity of

anthrocyanins. Journal of Agriculture and Food Chemistry, 45(2): 304-309.

Wang, J.S., Zhao, M.M., Zhao, Q.Z. and Jiang, Y.M. 2007. Antioxidant properties of

papain hydrolysates of wheat gluten in different oxidation systems. Food

Chemistry, 101(4): 1658-1663.

Wang, L. 2008. Dissection of mechanisms of Chinese medicinal formula Realgar-

Indigo naturalis as an effective treatment for promyelocytic leukemia.

Proceedings of National Academy of Sciences USA, 105(12): 4826-4831.

Warrier, P.K., Nambier, V.P. and Ramankutty, C. 2005. Indian Medicinal Plants- A

Compendium of 500 species, Vol. 5, Orient Longman Pvt. Ltd., Chennai, pp.

138-140.

Watson, A.J. 1995. Manipulation of cell death-the development of novel strategies for

the treatment of gastrointestinal disease. Alimentary Pharmacology and

Therapeutics, 9(3): 215-226.

Werker, E., Putievsky, E., Ravid, U., Duda, N. and Katziri, I. 1993. Glandular hairs

and essential oil in developing leaves of Ocimum basilicum L. (Lamiaceae).

Annals of Botany, 71(1): 43-50.

Werker, E. 2006. Function of essential oil-secreting glandular hairs in aromatic plants

of Lamiaceae a review. Flavour and Fragrance Journal, 8(5): 249-255.

WHO, 1995. Manual for Treatment of Diarrhoeal Diseases. World Health

Organization/Corporate Debt Restructurina, Geneva, p. 3.

WHO, 1996. Resistance to antimicrobial agents. Bull Scientific Working Group,

World Health Organization, Geneva, 71: 335-336.

WHO, 2000. General guidelines for methodologies on research and evaluation on

traditional medicine. WHO/EMD/TRM/2001.1, Geneva, Switzerland,

pp. 1-70.

194 �

WHO, 2002. Laboratory Diagnosis and Monitoring of Diabetes Mellitus. 20 Avenue

Appia, 1211 Geneva 27, Switzerland, pp. 1-29.

Williamson, P., van den Eijnde, S. and Schlegel, R.A. 2001. Phosphatidylserine

exposure and phagocytosis of apoptotic cells. Methods in Cell Biology,

66: 339-364.

Wils, P., Warnery, A., Phung-ba, V., Legrain, S. and Scherman, D. 1994. High

lipophilicity decreases drug transport across intestinal epithelial cells. Journal

of Pharmacology and Experimental Therapeutics, 269(2): 654- 658.

Wink, M., Alfermann, A.W., Franke, R., Wetterauer, B., Distl, M., Windhovel, J.,

Krohn, O., Fuss, E., Garden, H., Mohagheghzaden, A., Wildi, E. and

Ripplinger, P. 2005. Sustainable bioproduction of phytochemicals by plant in

vitro cultures; anticancer agents. Plant Genetic Resources, 3(02): 90-100.

Wink, M. 2008. Evolutionary advantage and molecular modes of action of

multi-component mixtures used in phytomedicine. Current Drug Metabolism,

9(10): 996-1009.

Witayapan, N., Sombat, C. and Okonogi, S. 2007. Antioxidant and antimicrobial

activities of Hyptis suaveolens essential oil. Scientia Pharmaceutica, 75(1):

35-46.

Wolf, B.B., Schuler, M., Echeverri, F. and Green, D.R. 1999. Caspase-3 is the

primary activator of apoptotic DNA fragmentation via DNA fragmentation

factor-45/inhibitor of caspase-activated DNAse inactivation. Journal of

Biological Chemistry, 274(43): 30651-30656.

Wretenjo, I. and Karlberg, B. 2002. Characterization of sterols in refined borage oils

by GC-MS. Journal of American Oil Chemists’ Society, 79(11): 1069-1074.

Xiao, J., Ni, X., Kai, G. and Chen, X. 2013. A review on structure-activity

relationship of dietary polyphenols inhibiting alpha-amylase. Critical Reviews

in Food Science and Nutrition, 53(5): 497-506.

Ximenes, R.M., Melo, A.M., Magalhães, L.P.M., de Souza, I.A. and de Albuquerque,

J.F.C. 2012. Antitumor activity of leaves from Hyptis mutabilis (A. Rich.)

Briq. (Lamiaceae) in mice bearing tumor. Dataset Papers in Pharmacology,

2013: 1-4.

195 �

Yang, C.S., Landau, J.M. and Huang, M.T. 2001. Inhibition of carcinogenesis by

dietary polyphenolic compounds. Annual Review of Nutrition, 21(1): 381-406.

Yaouba, A., Tatsadjieu, N., Jazet, D.P.M. and Mbofung, C.M. 2012. Inhibition of

fungal development in maize grains under storage condition by essential oils.

International Journal of Bioscience, 2 (6): 41-48.

Yasunaka, K., Abe, F. and Nagayama, A. 2005. Antibacterial activity of crude

extracts from Mexican medicinal plants and purified coumarins and

xanthones. Journal of Ethnopharmacology, 97(2): 293-299.

Yoganarasimhan, S.N. 2000. Hyptis suaveolens. In: Srinivasan, V. and Kosal Ram, N.

(ed.), Medicinal Plants of India. Vol. II. Bangalore: Cyber Media, wealth,

p. 282.

Young, I.S. and Wood, J.V. 2001. Antioxidants in health and disease. Journal of

Clinical Pathology, 54(3): 176-186.

Zamzami, N., Susin, S.A. and Marchetti, P. 1996. Mitochondrial control of nuclear

apoptosis. The Journal of Experimental Medicine, 183(4): 1533-1544.

Zebitz, C.P.W. 1984. Effects of some crude and azadirachtin enriched neem

Azadirachita indica seed kernel extracts on larvae of Aedes aegypti.

Entomologia Experimentalis et Applicata, 35: 11–14.

Zeshan, S.H., Hossain, T. and Azam, G. 2012. Phytochemical screening and

antidiarrhoeal activity of Hyptis suaveolens. Internet Journal of Applied

Research in Natural Products, 5(2): 1-4.

Zheng, W. and Wang, S.Y. 2001. Antioxidant activity and phenolic compounds in

selected herbs. Journal of Agriculture and Food Chemistry, 49(11):

5165-5170.

Ziegler, H.L., Jensen, T.H., Christensen, J., Staerk, D., Hagerstrand, H., Sittie, A.A.,

Olsen, C.E., Staalso, T., Ekpe, P. and Jaroszewski, J.W. 2002. Possible

artifacts in the in vitro determination of antimalarial activity of natural

products that incorporate into lipid bilayer: apparent antiplasmodial

activity of dehyroabientinol, a constituent of Hyptis suaveolens.

Planta Medica, 68(6): 547-549.