REFERENCES•Dissolution of aspirin from tablets containing various buffering agentsSource: Javaid, Karamat. Journal Of Pharmaceutical Sciences Volume: 61 Issue: 9 (1972-09-01) p. 1370-1373. ISSN: 0022-3549

•Loftin, Keith A., USGS, Craig D. Adams, University of Missouri--Rolla, Michael T. Meyer, USGS, and Rao Surampalli, USEPA. "Ects of Ionic Strength, Temperature, and PH on Degradation of Selected Antibiotics." Published in J. Environ. Qual. 37.378–386 (2008): 1-9. Print.

ACKNOWLEDGEMENTS

We would like to Thank Dr. White for making our undergraduate research experience amazing

We would like to Thank Gregory Goins for providing us with the necessary tools to thoroughly complete our presentation

We would like to thank Ms. Ashley Brown, our sweet lab assistant, for coaching us through our invigorating and educating lab

experience

We would like to thank our peers for maintaining a creative and constructive environment necessary to remain competitive and

strive to reach one common goal. " SUCCESS"

ABSTRACTAspirin, also known as acetylsalicylic acid(ASA), is a salicylate drug, often used as an analgesic to relieve minor aches and pains, as an antipyretic to reduce fever, and as an anti-inflammatory medication. Around the world, the normal usage is to take this medication by mouth. Drink a full glass of water (8 ounces/240 milliliters) with it unless your doctor tells you otherwise. Do not lie down for at least 10 minutes after you have taken this drug. If stomach upset occurs while you are taking this medication, you may take it with food or milk. Therefore, we decided to test these methods and determine the most effective solvent for the dissolution of aspirin. Since people consume aspirin with liquids we used four commonly used solvents to test our research. Another determining factor considered in the dissolution of aspirin was the possibility of various temperatures of the Solvents. In Hot, Cold, and Room temperature environments we hypothesized that sprite will work the best as far as dissolving the aspirin most effectively because it is the most acidic solvent; as opposed to using water, milk, or apple juice. One tablet was placed into each tube, once the desired temperature was reached, and the stopwatches were started. Tubes were shaken every 2 minutes for 30 seconds throughout this process. The time for complete dissolution was recorded in minutes and seconds and documented. This process was repeated for all 12 tubes. Once all times were recorded the data was placed in charts and a "raw time" was calculated for each liquid to determine which liquid worked the quickest in overall dissolution. For all methods water was the best solvent to use for the consumption and dissolution of aspirin.

CONCLUSIONS

MATERIALS

OBJECTIVE

AVERAGE DISSOLUTION TIMES BASED ON TEMPREATURE SETTING

RESULTS

METHODS

Does Temperature Affect The Dissolution Rate of Aspirin?

Alexis Montgomery Tomekia Phillips Shakkirah Simmons and C. Dinitra White2

Department of Chemistry1 and Department of Biology2

North Carolina Agricultural and Technical State University, Greensboro, NC 27411

•We started by labeling the 12 tubes by the name of the liquid they would contain and also by the temperature in which they would be stored.

•When all the tubes were labeled, 30 mL of each liquid was measured into the corresponding tubes.

•The tubes after being labeled were placed into one of the 3 designated temperature settings:Room,Cold, or Hot(temps. range from 4 to 70 degrees Celsius).

•One tablet was placed into each tube, once the desired temperature was reached, and the stopwatches were started.

•Tubes were shaken every 2 minutes for 30 seconds throughout this process.

•The time for complete dissolution was recorded in minutes and seconds and documented. This process was repeated for all 12 tubes.

•Once all times were recorded the data was placed in charts and a "raw time" was calculated for each liquid to determine which liquid worked the quickest in overall dissolution

• 12 50 mL pipette tubes• 12 CounterAct Pain Tablets • 90 mL VeryFine Apple Juice

• 90 ml Milk• 90 mL Water• 90 mL Sprite• Water Bath

• Cold Room/Walk-In Refrigerator• Lab Station• Stopwatches

For all methods water was the best solvent to use for the consumption and dissolution of aspirin. therefore, leading to a false hypothesis.

Although medical Professionals recommend an individual uses milk as a substitute for water, this study shows that since milk had the longest dissolutioin rate throughout the different temperatures, it not only will increase the longetivity of pain, but also has the potential to not completely disolve at all.

HYPOTHESIS

• To determine whether or not various temperature ranges and solvents will have an affect on the time it takes to dissolve an aspirin tablet.

We hypothesized that Sprite will work best as far as dissololving the aspirin most effectively because it is the most acidic solvent

Room Temperature

Liquid Milk Sprite Water Apple Juice

Dissolution Time

58 min 15 sec 34 min 15 sec

21 min 43 sec

45 min 12 sec

Hot Temperature

Liquid Milk Sprite Water Apple Juice

Dissolution Time

44 min 03 sec

8 min 20 sec 2 min 20 sec 4 min 43 sec

Cold Temperature

Liquid Milk Sprite Water Apple Juice

Dissolution Time

2 hr 2 mins 12 secs

1 hr 24 mins 15 secs

53 mins 2 hr 2 mins 12 secs

Average Dissolution Time For Each Temperature Zone

Hot 39 mins 7 secs

Cold 1 hr 35 mins 34 secs

Room 40 min 11 sec