regis james o'keefe, m.d. - washington university in … · web viewregis j. o’keefe, md,...

REGIS J. O’KEEFE, MD, PhDCurriculum Vitae

Personal

Office address: Washington University School of Medicine660 South Euclid, Campus Box 8233St. Louis, MO 63110

Phone: 314-747-8414Fax: 314-747-2599Email: [email protected]

Home address: 4545 Forest Park Avenue, Apt B209, St. Louis, MO 63108

Born: August 4, 1959, Pittsburgh, PA

Married: July 23, 1983, Carol Lee Gabardine

Children:Patrick Regis, born June 26, 1990 Daniel Eugene, born April 2, 1992Kaylin Marie, born October 18, 1994Abigail Lee, born December 16, 1997

Education and Training

Baldwin High School, Pittsburgh, PA 1973 – 1977Highest HonorsClass PresidentStudent Council President

Yale University, 1977 – 1981, B.A.Phi Beta Kappa Magna Cum LaudeDistinction in Major (Philosophy and Religious Studies)Varsity basketball letter, 197 – 81, Captain 1980 – 81Freshman Counselor, 1980 – 81

Harvard Medical School, 1981-1985, M.D.Admissions Committee, 1982 – 83Cardiovascular Research, Massachusetts General Hospital, 6/83 to 8/83 and 1/85 to 5/85

University of Rochester, School of Medicine and Dentistry, 2000, Ph.D. Biochemistry and Biophysics

New England Deaconess Hospital, Harvard Medical School, 1985 – 86Surgical Internship

University of Rochester School of Medicine and Dentistry, Instructor and Fellow in Research, Orthopaedic Research Laboratories, 6/86 to 6/88 Endocrinology Training Grant, 1986 – 1988

Resident in Orthopaedics, The University of Rochester Medical Center, Rochester, NY, 7/88 - 6/92Fellowship in Orthopaedic Oncology, Massachusetts General Hospital, 7/92 – 6/93

Academic Appointments

Instructor, Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY, 7/93 – 3/94

Assistant Professor, Orthopaedics and Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 4/94 – 04/97

Associate Professor, Orthopaedics and Oncology, University of Rochester School of Medicine and Dentistry, Rochester, NY, 4/97 – 6/00

Professor, Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY, 6/00 – 09/14

Director, Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, NY, 7/05 – 11/11

Chair, Department of Orthopaedics and Rehabilitation, University of Rochester School of Medicine and Dentistry, Rochester, NY, 3/07 – 09/14

Marjorie Strong Wehle Professor in Orthopaedics, University of Rochester School of Medicine and Dentistry, Rochester, NY, 03/07 – 09/14

Professor, Department of Pathology and Laboratory Medicine, University of Rochester School of Dentistry, Rochester, NY, 07/09 – 09/14

Professor, Department of Biochemistry and Biophysics, University of Rochester School of Dentistry, Rochester, NY, 07/10 – 09/14

Associate Dean for Clinical Affairs - Department of Dean's Office, University of Rochester School of Medicine and Dentistry, Rochester, NY, 07/11 – 09/14

Professor and Chair, Department of Orthopaedic Surgery, Washington University School of Medicine, St. Louis, MO, 10/1/14 - present

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Society Memberships

American Academy of Orthopaedic Surgeons

American Association for the Advancement of Science

American Board of Orthopaedic Surgeons, Inc.

American Orthopaedic Association

American Society of Bone and Mineral Research

Association of American Physicians

Association of Osteobiology

Interurban Orthopaedic Society

Monroe Medical Society

Musculoskeletal Tumor Society

New York Academy of Science

New York State Medical Society

Orthopaedic Research Society

Committees

University of Rochester

University of Rochester Research Core Facility Review Committee, 4/2003 – 6/2006

University of Rochester Executive Medical Scientist Training Program (“MSTP”) Program Committee, Chairman, 5/2003 – 2014

University of Rochester Incentives Committee, 2003 – 2005

University of Rochester Scientific Publishing Committee, 2005 – 2014

University of Rochester Medical School Advisory Council (MEDSAC) Committee, 2005 – 2014

University of Rochester Medical School Advisory Council (MEDSAC) Steering Committee, 2005 – 2008

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University of Rochester Medical Center Research CEO Research Advisory Group, 2005 – 2014

University of Rochester Medical Center Retention Policy Committee, 2006 – 2008

University of Rochester Medical Faculty Group Executive Committee, 2006 – 2014

University of Rochester Medical Center Clinical CEO Advisory Group, 2007 – 2014

University of Rochester Medical Center Lymphoma Specialized Programs of Research Excellence (SPORE) Advisory Board, 2007 – 2014

University of Rochester Medical Center CEO Strategic Group, 2011 – 2014

Washington University:

Executive Faculty, 2014 – presentExecutive Faculty Administration and Finance Committee, 2014 – presentFaculty Practice Plan Board of Directors, 2014 - presentGovernance Committee, 2014 – presentResearch Affairs Committee, 2014 – presentSiteman Cancer Center, 2014 - present

Barnes-Jewish Hospital

Medical Executive CommitteePeri-Operative Steering Committee

Search committees

Chair of the Hematology/Oncology Division Director Search Committee, University of Rochester Medical Center, 2007

Chair of the Anesthesiology Department Chair Search Committee, University of Rochester Medical Center, 2010 – 2011

University of Rochester Scientist Development Committee, 2010 – 2014

American Academy of Orthopedic Surgeons

Basic Science Subcommittee Member 1996 – 2002

Council on Research and Scientific Affairs Member 1999 – 2001

Academic Affairs Project Team Member 2001

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Council on Academic Affairs Member 2001 – 2006

Clinician-Scientist Program Committee Chair 2001 – 2006

United States Bone and Joint Decade Project Team Chair 2003 – 2007

Orthopaedic Basic Science Text, 3rd Edition Co-Chair 2005 – 2007

Molecular Biology and Therapeutics in Musculoskeletal Oncology Symposium Co-Chair 2007 – 2008

AAOS Annual Meeting Task Force Member 2008

Orthopaedic Research Society

Program Committee, Orthopaedic Research Society Meeting, New Orleans, LA, Adjunct Reviewer, 1998

Program Committee, Orthopaedic Research Society Meeting Anaheim, CA, Adjunct Reviewer, 1999

Program Committee, Orthopaedic Research Society Meeting Orlando, FL, Full Member, 2000

Treasurer, 2004 – 2007

Mentoring Committee, 2005 – present

Program Committee, 2007 – 2010

Executive Committee, 2007 – present

President-elect, 2008

President, February 2009 – March 2010

Immediate Past President, March 2010 – January 2011

American Orthopaedic Association

Resident’s Conference Committee, 1999

Member, 1999 – present

Executive Committee, 1999 – 2001

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Membership Committee, 1999 – 2001

Finance Committee, 1999 – 2001

Board of Directors, 1999 – 2001

Publication Committee, 2000 – 2003

Critical Issues Committee, 2002 – 2004

ABC Traveling Fellowship Committee, 2003 – 2006

Emerging Leaders Program Guide, 2004 – 2006

Critical Issues Committee, 2009 – 2012; Committee Chair 2012-present

American Board of Orthopaedic Surgery

Director, 2008 – present

Chair, Written Examination Committee, 2009 – present

Orthopaedic Research Education Foundation

Board of Trustees, 2003 – 2011

Chair, Grant Writing Workshop, 2006 – 2010

Executive Committee, 2007 – 2011

Secretary, 2007 – 2011

Awards

AOA Resident Traveling Research Award, “Differential expression of transforming growth factor-ß receptors and biological effects in maturationally distinct subpopulations of growth plate chondrocytes.” 1988

Kappa Delta Award, Orthopaedic Research and Education Foundation, 1995

The Dane and Mary Louise Miller Endowed Research Grant, Orthopaedic Research and Educational Foundation, 1997

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Dean’s Endowed Chair, Associate Professor of Orthopaedics, University of RochesterSchool of Medicine, 1998

American Orthopaedic Association ABC Traveling Fellowship, 1999

Dean’s Endowed Chair, Professor of Orthopaedics and Oncology, University of Rochester School of Medicine, 2000

Fifth Annual Dr. Marvin J. Hoffman Award in the Area of Faculty Mentoring to Medical Students, Awarded at the Annual Hoffman Awards Ceremony, April 25, 2003

Best Doctors in America for Cancerous Tumor Surgery, 2009

Orthopaedic Research Society and the Orthopaedic Research and Education Foundation 2013 Distinguished Investigator Award. Received on March 16, 2014

Research Support

Career Development Award, Orthopaedic Research and Education Foundation, “Proto-oncogene expression and the regulation of chondrocyte metabolism.” Principal Investigator, 7/93 – 6/95

Wilmot Cancer Research Fellowship, James P. Wilmot Foundation, University of Rochester, 7/93 – 6/96

Orthopaedic Research and Educational Foundation, “Identification and characterization of an operant anti-inflammatory mechanism for the control of wear debris osteolysis.” 7/97 – 7/99

Wear Debris Osteolysis: New Strategies for Prevention, NIH R29 AR44220, Principal Investigator, 9/97 – 8/02

Autocrine and Ionic Regulation of Chondrocyte Phenotype, NIH AR40325, Co-Investigator, (R. Rosier, Principal Investigator) 9/97 – 08/02

Growth Factors and Epiphyseal Chondrocyte Maturation. NIH RO1 AR38945, Principal Investigator, 5/98 – 4/07

Prostaglandin Signaling in Wear Debris-induced Osteolysis, Principal Investigator, National Institute of Arthritis and Musculoskeletal and Skin Disease, R01 AR46545, 7/00 – 6/10

Gene therapy for Prosthetic Loosening, NIH R01 AR46545, Principal Investigator, 9/00 – 8/04

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Acetabular Bone Loss Following Prosthetic Hip Arthroplasty, RO1 AR48149 Co-Principal Investigator 4/02 – 3/05

Cellular and Molecular Effects of Lead on Chondrogenesis and Cartilage Differentiation, P01 ES11854, 8/02 – 8/06. Principal Investigator, Project 2 in Lead Toxicity in the Skeleton and its Role in Osteoporosis. Program Project, J.E. Puzas, PI, 8/02 – 8/06

Prostaglandin Signaling in Wear Debris–Induced Osteolysis, NIH R01 AR46545, Principal Investigator, 07/00 – 06/11

Training in Orthopaedic Research, NIH T32 AR053459, Principal Investigator, 05/06 – 04/11

The use of genetic models to define the role of beta-catenin in post-natal growth, National Institute of Arthritis and Musculoskeletal and Skin Disease, R01 AR 05371, Principal Investigator, 9/07 – 8/12

Cyclooxygenases and Bone Repair, NIH RO1 AR48681, Principal Investigator RO1 7/09 – 6/14

Translating Molecular Signal Pathways to Orthopaedic Trauma Care, Dr. Randy Rosier, Program Director, NIH P50, AR054041, Principal Investigator of Project 2, 8/06 – 7/11

The Mechanism through which TGF-beta Maintains Chondrocytes in Proliferating StagePrincipal Investigator: Di Chen; Role: Co-Investigator, NIH National Institute of Arthritis and Musculoskeletal and Skin Disease, R01 AR054465, 2/07 – 1/11

Molecular Biology and Therapeutics in Musculoskeletal Oncology (MBTMO) Research, NIH R13 CA135939, Awarded with Priority Score 150, Principal investigator, 9/08

Allografts and Gene Therapy in Flexor Tendon Tissue Engineering, National Institute of Arthritis and Musculoskeletal and Skin Disease, Co-Investigator, R01AR056696, 7/09 – 6/14

Improving Orthopaedic Outcomes through a National TJR Registry, NIH, CO-PI, Prime Award No. 5-P50-HS0189-10-02 (Subaward No. 6127964/RFS2011171), 4/10 – 03/14

Notch Signaling in Cartilage Development, NIH, Co-Investigator, R01AR057022, 7/10 – 06/15

Development of siRNA Technology to Prevent Scar Formation in Tendon Repair, Department of Defense, Principal Investigator, W81XWH–10-1-0841, 10/10 – 09/13

The University of Rochester Core Center for Musculoskeletal Biology and Medicine, NIH National Institute of Arthritis and Musculoskeletal and Skin Disease, Advisory Committee Member, P30AR061307-01, 08/11 – 06/16

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DKK1-Ab Regulation of the Stem Cell Responses to Skeletal Injury, AMGEN, Principal Investigator, 12/12 – 11/15

Promoting MSC-mediated Musculoskeletal tissue regeneration using sustained, localized SIRNA delivery, NYSTEM, Co-Investigator, 3/13 – 02/15

Translating Molecular Signal Pathways to Orthopaedic Trauma Care, Program Director and PI of Project 1; NIH P50, AR054041, 09/12 – 08/17

National Research Review Committees

National Institutes of Health Review Panels

Study Section Member, National Institutes of Health RFA-HD-93-011 “Biomaterials to restore function in people with physical disabilities.” NIH, December 1 – 3, 1993

Orthopaedic Study Section, National Institutes of Health, Ad Hoc Reviewer, February 21 – 23, 1999

Orthopaedic Study Section, National Institutes of Health, Ad Hoc Reviewer, June 26 – 27, 2000

Orthopaedic Study Section, National Institutes of Health, Permanent Member, October 2000 – 2003

Orthopaedic Study Section, National Institutes of Health, Chair, October 2003 – 2004

NIH GCRC Grant Reviewer, General Clinical Research Center Grant Review, Duke University, Durham, NC, September, 16 – 17, 2003

NIH Skeletal Biology and Skeletal Regeneration Study Section, Chair, 2004 – 2005

NIH Electronic Review, Chair, ZRG1 MOSS-A (02) Skeletal Biology Structure and Disease Special Emphasis Panel, November 2005

NIH Electronic Review, Chair, ZRG1 MOSS-A (02) Musculoskeletal Hard Tissue Special Emphasis Panel, April 2006

National Institutes of Arthritis and Musculoskeletal and Skin Diseases (“NIAMS”), Musculoskeletal Injury and Trauma Roundtable, Advisory Panel, January 22, 2007

NIH Skeletal Biology Structure & Regeneration Study Section, Center for Scientific Review, Washington, DC, June 4, 2007

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Proteus Syndrome Skeletal Biology (PSSB) Workshop, (Co-Organizer), National Institutes of Health, Bethesda, Maryland, September 26 – 28, 2007

National Institutes of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health Review R03 Grants, July 2008

NIAMS Roundtable on Enhancing Clinical Trials in Orthopaedics and Osteoarthritis, Bethesda, MD, December 14, 2009

NIAMS Advisory Council (National Institute of Arthritis and Musculoskeletal and Skin Diseases NIH, DHHS), Bethesda, MD, February 2010 – February 2012

NIH Council Service

National Institutes of Health Council of Councils (CoC) Advisory Committee - November 1, 2010 – 2013

National Institutes of Health (NIH) National Arthritis and Musculoskeletal and Skin Disease Advisory Council - March 30, 2010 – 2013

NIAMS Advisory Council Working Group on Clinical Trials - June 15, 2010 – 2013

Howard Hughes Medical Institute Review Panels

HHMI Research Training Fellowships Review Committee Information, Washington, DC, February 18, 2010

HHMI Research Training Fellowships Review Committee Information, Washington, DC, February 17, 2011

Howard Hughes Medical Institute Research Training Fellowships Review Committee, January 2010 – February 2012

NASA Review Panels

American Institute of Biological Sciences, NASA Life and Biomedical Sciences Division Peer Review Committee, July 1994

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American Institute of Biological Sciences, NASA Bone Health and Military Medical Readiness, Committee on genetics and stress fracture, Washington, DC, November 1997

Shriners Hospitals Research Panels

Shriners Hospitals for Children Research Advisory Board, Member, 2006 – present.

United States Military Review Panels

United States Army Review Panel, Chair, July 2006

Orthopaedic Trauma Research Program (OTRP) US Army Institute of Surgical Research, Panel Chair, San Antonio, Houston, Texas, September 2007

Other Review Panels

Musculoskeletal Transplant Foundation Scientific Grant Award Committee, October 1996, October 1997, and October 1998

Reviewer, Whitaker Foundation Grants, April 1998

Bristol Meyers Squibb Zimmer Annual Distinguished Award in Orthopaedic Research Selection Committee, Vail, CO, January 2001

The Bone and Joint Decade, Scientific Grant Award Committee, April 2006

Reviewer, Pilot/Feasibility Study, Dermatology and Immunobiology, Yale University, January 2007

US Bone & Joint Decade Scientific Committee, Review and Select Awardees for the 2nd BJD Award and Scholarships, March 2008

Merck & Co., Osteoporosis Orthopaedic Expert Input Forum, New Brunswick, New Jersey, June 26 – 27, 2008

DoD Peer Reviewed Orthopaedic Research Program Stakeholders Meeting, Washington, DC, March 26 – 27, 2009

All Hands Armed Forces Institute of Regenerative Medicine (AFIRM), St. Petersburg, FL, January 12 – 15, 2010

University of Iowa, Consultant to the Carver College of Medicine for the Department of Orthopaedic Surgery and Rehabilitation, Cedar Rapids, IA, July 15, 2010

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All Hands Armed Forces Institute of Regenerative Medicine (AFIRM), Washington, DC, December 9-10, 2010

BIDMC Orthopedic Surgery Review, Department of Orthopedic Surgery, Beth Israel Deaconess Medical Center, Boston, MA, March 16 – 17, 2011

Hospital for Special Surgery (“HSS”) Scientific Advisory Board External Review, New York, NY, April 11, 2011

Research Lobbying Activities

American Academy of Orthopaedic Surgeons, Research Lobby Day Participant, February 11 – 13, 2004

American Academy of Orthopaedic Surgeons, Research Lobby Day Participant, March 16 – 18, 2005

American Academy of Orthopaedic Surgeons, Research Lobby Day Participant, March 2007

Board Memberships

American Board of Orthopaedic Surgery, Question Writing Task Force, 2001 – present

Aircast Foundation, Scientific Board, 2002- 2006; Chair, 2005 – 2006

Orthopaedic Research and Education Foundation, Executive Committee 2003 – 2011, Secretary, 2007 – 2011

Orthopaedic Research Society, Board of Directors 2003 – 2011, President 2010 – 2011, Treasurer 2004 – 2007; Program Committee Member, 2007 – 2010

United States Bone and Joint Decade, President 2003 – 2005, Chair 2003 – 2007, Board member, 2005 – present

Aircast Foundation, Extremity War Trauma Research Foundation Board of Directors, 2008 – 2009

Hospital for Special Surgery Scientific Advisory Board, 2006

American Board of Orthopaedic Surgery, Chair, Written Examinations Committee, Committee Member of Research Committee, Oral Examinations Committee and Maintenance of Certification Committee, February 2008 – present

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Thesis Committees

Daniel Jang, The University of New South Wales, Sydney Australia, “Studies on nitric oxide in cartilage metabolism and septic arthritis.” Thesis Examiner, 1999

Christopher Grimsrud, University of Rochester School of Medicine, “Bone morphogenetic proteins and chondrocyte maturation.” Ph.D. Research Advisor, 1995 – 1999

Andreia Ionescu, University of Rochester School of Medicine, “The role of CREB and c-Fos in PTHrP signaling in chondrocytes.” Ph.D. Research Advisor, 1998 – 2003

Andrew Gordon, University of Rochester School of Medicine, “The role of NFkB in tumor metastasis.” Ph.D. Research Committee, 1998 – 2003

Dongwei Zhang, University of Rochester School of Medicine, “BMP receptors in skeletal development and repair.” Ph.D. Research Advisor, 1999 – 2003

Lea Gunnell, University of Rochester School of Medicine, “ATF-2 in skeletal development.” Ph.D. Research Advisor, 2002 – present

David Reynolds, University of Rochester School of Medicine, “Analysis of grafted bone strength and structure and the effects of targeted gene therapy.” Ph.D. Research Advisor, 2002 – 2009

Xiaochao Wei, University of Rochester School of Medicine, “The role of the synovial fibroblast in periprosthetic loosening.” Ph.D. Research Advisor, 2002 – present

Yu Zhang, University of Rochester School of Medicine, Department of Pathology, “Growth factors and cell cycle regulation in endochondral ossification.” Ph.D. Research Advisor, 2003 – 2008

Christine Clark, University of Rochester School of Medicine, “Cyclooxygenases and the regulation of chondrocyte maturation.” Ph.D. Research Advisor, 2003 – 2008

Mo Chen, University of Rochester School of Medicine and Department of Genetics, "B-Catenin Signaling in Postnatal Cartilage Development.” Ph.D. Research Advisor, 2004 – 2007

Alayna Loiselle, University of Rochester School of Medicine, Department of Pathology, “Molecular events of tendon repair in an in vivo murine intra-synovial tendon healing model.” Ph.D. Research Advisor, 2004 – 2009

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Debbie Dao, University of Rochester School of Medicine, Department of Pathology, “The role of axin 2 and beta-catenin on skeletal development and cartilage metabolism.” Ph.D. Research Advisor, 2006 – 2011

Ming Kung, University of Rochester School of Medicine, Department of Environmental Medicine, “Mechanisms through which cigarette smoke regulates bone formation.” Thesis co-Advisor (with Michael Zuscik, Ph.D.), 2006 – present

Minjie Zhang, University of Rochester School of Medicine, Department of Biomedical Genetics, “The role of the various EP receptors in stem cell differentiation and bone repair.” Thesis Advisor, 2007 – 2011

Yang Gao, University of Rochester School of Medicine, Department of Biomedical Genetics, Thesis Committee Member, 2007 – present

ShanShan Shi, University of Rochester School of Medicine, Department of Pathology, “Tendon healing and scar formation: Modulation of TGF-beta signaling” June 2009 – present

Marina Feigenson, University of Rochester School of Medicine, Department of Biochemistry, “The role of Prostaglandin E Receptor 1 in bone homeostasis and fracture repair.” Thesis Advisor, 2010 – present.

Yongchun Zhang, University of Rochester School of Medicine, Department of Biochemistry, “Investigating the roles of Bmp-2/Smad and Ihh signaling in Beta-catenin-mediated endochondral bone formation.” Thesis Advisor, 2011 – present.

Post Doctoral Trainees

Theodore H. Blaine, MD: “The role of cAMP/CREB signaling in macrophage activation secondary to particulate debris.” 07/94 – 07/95

Paul Pollice, MD: The role of IL-10 as a natural inhibitor of peri-prosthetic osteolysis.” 07/95 – 07/96

Susan Bukata, MD: Hydroxyapatite particles induce monocyte production of TNF-alpha and bone resorption in vitro and in vivo.” 07/96 – 07/98

Allen P. Lu, MD: “The role of NFkB in the macrophage response to particulate debris.” 07/98 – 07/99

Xeufeng Li, MD, “The regulation of chondrocyte maturation by BMP’s and interaction with other growth factors.” 06/98 – 02/03

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Cristin Ferguson, MD, “The regulation of chondrocyte maturation through SMAD signaling.” 04/99 – 07/00

Alexander Soloviev, PhD, “Mechanisms of activation of NFkB by debris particles and regulation of TNF-alpha in macrophages.” 08/99 – 06/01

Jill-Marie Gelinas, MD, “The role of IL-6 in periprosthetic osteolysis.” 08/01 – 09/02

Michael Darowish, MD, “The role of IL-6 in wear debris mediates osteolysis.” 06/04 – 06/05

Tian-fang Li, MD, “Smad3 regulation of chondrocyte maturation.” 06/02 – 6/06

Yufeng Dong, MD, “Wnt expression and signaling in endochondral bone formation.” 09/02 – 09/07

Jennifer Jonason, PhD, “Mechanisms involved in VEGF regulation by beta-cateinin.” 9/07 – present

Calvin Hu, MD, Post doctoral fellow, “The development of a non-union model in murine fracture healing.” 07/08 – 6/09

Sarah Offley, MD, Post doctoral fellow, “The development of a non-union model in murine fracture healing.” 07/09 – 06/10

Kiminori Yukata, PhD, “Intracellular signals regulating stem cell population recruitment and expansion in fracture young and aged bone repair.” 06/09 – 05/11

Zaneb Yaseen, MD, “The development of a non-union model in murine fracture healing.” 07/10 – 06/11

Medical Student Trainee

James Hsu, B.A., “Effect of IL-10 on macrophage responses to wear particles” 06/97 – 06/98

Dhruv Pateder, B.S., “Regulation of PTHrP expression by chondrocytes, role of TGF-beta and Smad-mediated signaling.” 6/99 – 6/00

Emily Carmody, B.S., “IL-10 mediated gene therapy prevents wear debris induced bone resorption. 6/00 – 6/01

Ra’Kerry Rahman, B.S., “IL-6 regulation by debris particles and a role in periprosthetic osteolysis.” 6/02 – 6/03

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Ankur Chawla, B.S. “Distraction osteogenesis in the setting of chronic inflammation.” 8/03 – 8/04 (Awarded a Howard Hughes Medical Student Fellowship)

Amish Naik, B.S. "A comprehensive study of fracture healing in aged versus young mice." 8/04 – 8/05 (Awarded a Howard Hughes Medical Student Fellowship)

Emmanuel Menga, “Smad-3 deficiency and fracture healing.” 6/06 – 8/06

Taylor Buckley, “The effect of lead on in vivo chondrogenesis in a murine model.” 7/06 – 6/07

Stephen George, “The effect of androgens and environmental exposure to the phthalates on bone repair.” 6/06 – 8/07

Evan Katzel, “The role of Smad3 on tendon repair and adhesion formation.” 7/07 – 7/08

Sirish Kondabolu, “Modulation of tendon scar formation with siRNA against TGF-beta signaling targets.” 07/10 – 07/11

Matthew Brown, “Fracture Healing and Obesity.” 07/11 – 07/12

Student/Fellowship Grant Awards

Paul Pollice, M.D. Orthopaedic Research and Educational Foundation, Resident Fellowship, 1995 – 1996

Susan Bukata, M.D., Orthopaedic Research and Educational Foundation, Resident Fellowship, 6/96 – 6/98

Ra’Kerry Rahman, B.S., Bristol-Myer Squibb, National Medical Academic Medicine Fellowship, 6/02 – 6/03

Ankur Chawla, B.S., Howard Hughes Medical Student Fellowship, 8/03 – 8/04

Erik R. Lovria, Medical Student Summer Orthopaedic Research and Educational Foundation Fellowship, 6/04 – 8/04

Michael Darowish, M.D., Orthopaedic Research and Educational Foundation Fellowship, 6/04 – 8/05

Amish Naik, B.S., Howard Hughes Medical Student Fellowship, 8/05 – 8/06

Stephen George, Howard Hughes Medical Student Fellowship, 8/06 – 8/07

Evan Katzel, Clinical Translation Science Award, University of Rochester, 7/07 – 7/08

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Sirish Kondabolu, Clinical Translation Science Award, University of Rochester, 07/10 – 07/11

Matthew Brown, Clinical Translation Science Award, University of Rochester, 07/11 – 07/12

Graduate School Teaching

Pathology 493: Pathways of Human Disease (Graduate School Course). “Skeletal Development and Repair: The Role of Mesenchymal Stem Cells.” March 25, 2003

CMM Faculty Research Presentations: “Growth Plate Chondrocyte Differentiation and Maturation; Biochemical Mechanisms of Prosthetic Implant Loosening; Mechanisms of Tumor Mediated Bone Loss.” October 7, 2003

Pathology 493: Pathways of Human Disease “Skeletal Development and Repair: “The Role of Stem Cells.” January 29, 2004

Pathology 593: Molecular Basis of Disease “The Role of Stem Cells in Musculoskeletal Repair.” September 20, 2005

CMM Faculty Research Presentations: “Cell signaling in musculoskeletal tissues.” September 14, 2006

Pathology 493: Pathways of Human Disease (Graduate School Course). “Cell Signaling and Regulations of Growth and Development.” September 14, 2006

Medical School Teaching

Bench to Bedside: (Third year medical students) Journal Club Review: “The Treatment of Osteoporosis.” March 25, 2003

Ortho Double Helix Curriculum: (First year medical students). Lower Extremity Module II

Process of Discovery Lecture, “Genetic Advances in the Understanding of Osteoporosis, Past Present and Future.” February 5, 2004

Process of Discovery (Required 4th year medical school course.) “Respondent of Student Abstracts and Selector of Awards.” February 26, 2004

Process of Discovery Lecture, “Non-Modifiable Factors Influencing the Skeleton, and What Does the Future Hold for Osteoporosis.” February 3, 2005

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Process of Discovery Lecture, “Understanding the Cellular and Molecular Signals Required for Allograft Revitalization and Remodeling.” February 27, 2006

Scientific Reasoning in Medicine Course, “Models to Understand Bone Repair: Toward Improving Patient Care.” May 5, 2006

Process of Discovery Lecture, “Understanding and Improving Fracture Healing with Aging.” February 21, 2007

Problem Based Learning Module, 2nd year medical students, “Upper Extremity Disorders.” April 4, 2007


Upstate New York Musculoskeletal Basic Science Course, “Growth Plate Physiology.” April 3, 2008


Phelps Colloquium Series Lecture "Your aging bones - Growing older is getting better: Stem cells, hormones, and novel therapies." February 3, 2010


Surgery Interest Group Lecture, “Work Orthopaedic Tumor Surgeon.” February 7, 2011

Process of Discovery Lecture, “Translating Scientific Discovery into Better Bone Healing", February 10, 2011

Second Friday Social Seminar Lecture Series, “Improving Orthopaedic Care ThroughTranslational and Clinical Research: Opportunities and Challenges.” February 11, 2011

Process of Discovery Lecture, “Translating Scientific Discovery into Better Bone Healing”, February 16, 2012

Process of Discovery Lecture, “Translating Scientific Discovery into Better Bone Healing”, February 18, 2013

Course Faculty

“Women’s Health: Special Imaging and Intervention.” Wyndham Aruba Beach Resort, Aruba, July 31 – August 4, 2001

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“Emerging Technologies in Spine Surgery.” Sagamore Resort, Bolton Landing, NY, June 20 – 23, 2002

“Your Winning Playbook for Healthy Joints.” Men’s Health Day, University of Rochester, Rochester, NY, September 12, 2008

Editorial Service

Biochimica et Biophysica ACTA

Biomaterials

Bone

Calcified Tissue International

Cells, Tissues, and Organs

Clinical Cancer Research

Clinical Orthopaedics and Related Research

Development

Developmental Dynamics

Endocrinology

Experimental Cell Research

Gene

Journal of Biological Chemistry

Journal of Bone and Joint Surgery

Journal of Bone and Mineral Research

Journal of Cellular Biochemistry

Journal of Cellular Physiology

Journal of Clinical Investigation

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Journal of Histochemistry and Cytochemistry

Journal of Orthopaedic Research

Journal of Orthopaedic Trauma

Molecular and Cellular Biology

Molecular Therapy

Nature Medicine

Osteoarthritis and Cartilage

Plos One

Pediatric Research

Spine

Tissue Engineering

Toxicology and Applied Pharmacology

Editorial Boards

Journal of Bone and Joint Surgery, Basic Science, 2001 – 2006

Journal of Bone and Mineral Research, 2002 – present

Associate Editor - Journal of Bone and Mineral Research, 2008 – 2012

Associate Editor – Bone, 2013 – present

Books/Journals Edited

Current Opinions in Orthopaedics, Metabolic Bone Disease and Basic Science Edition Editor, 2000

Orthopaedic Knowledge Update 7, Basic Science Section Editor, 2001

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Current Opinions in Orthopaedics, Metabolic Bone Disease and Basic Science Edition Editor, 2001

Orthopaedic Basic Science, Foundations of Clinical Practice, Third Edition, eds. Thomas A. Einhorn, MD, Regis J. O'Keefe, MD, PhD, and Joseph A. Buckwalter, AAOS Publications, 2007

Orthopaedic Basic Science, Foundations of Clinical Practice, Fourth Edition, eds. Regis J. O’Keefe, MD, PhD, Joshua J. Jacobs, MD, Constance R. Chu, MD, and Thomas A. Einhorn, MD. AAOS Publications, 2012

Publications

1. O'Keefe, RJ, Domalik-Wawrzynski, L, Guerrero, JL Rosow, CE, Lowenstein, E, and Powell, WJ: Locally and neurally mediated effects of sufentanil on canine skeletal muscle vascular resistance. Journal of. Pharmacology and Experimental Therapeutics 242:699-706, 1987

2. O'Keefe, RJ, Puzas, JE, Brand, JS, and Rosier, RN: Effects of transforming growth factor-ß on matrix synthesis by chick growth plate chondrocytes. Endocrinology 122:2953-2961, 1988

3. O'Keefe, RJ, Puzas, JE, Brand, JS, and Rosier, RN: Effect of transforming growth factor-ß on DNA synthesis by growth plate chondrocytes: Modulation by factors present in serum. Calcified Tissue International 43:352-358, 1988

4. Rosier, RN, O'Keefe, RJ, Crabb, I.D., and Puzas, JE: Transforming growth factor beta: An autocrine regulator of chondrocytes. Connective Tissue Research 20:295-301, 1989

5. O'Keefe, RJ, Crabb, ID, Puzas, JE, and Rosier, RN.: Countercurrent centrifugal elutriation: A high-resolution method for the separation of growth plate chondrocytes. Journal of Bone and Joint Surgery 71A: 607-620, 1989

6. O'Keefe, RJ, Rosier, RN, and Puzas, JE: Differential expression of biological effects in maturationally distinct subpopulations of growth plate chondrocytes. Connective Tissue Research 24:53-66, 1990

7. Crabb, ID, O'Keefe, RJ, Puzas, JE, and Rosier, RN: Synergistic effect of transforming growth factor-ß and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes. Journal of Bone and Mineral Research 5:1105-1112, 1990

8. O'Keefe RJ; Jones JA; Hurwitz SR. "Bilateral sacroiliac joint fracture-dislocation requiring late coccygectomy: a case report." The Journal of Trauma 1992;33(5):793-4. 1992

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9. Crabb, ID, O'Keefe, RJ, Puzas, JE, and Rosier, RN: Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes. Calcified Tissue International 50:61-66, 1992

10. O'Keefe, RJ, Crabb, ID, Puzas, JE, and Rosier, RN: Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes. Journal of Bone and Mineral Research 7:397-404, 1992

11. O'Keefe, RJ, Crabb, ID, Puzas, JE, and Rosier, RN: Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I. Journal of Orthopaedic Research 12 (3): 299-310, 1994

12. O'Keefe, RJ, Puzas, JE, Loveys, LS, Hicks, DG, and Rosier, RN: Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization. Journal of Bone and Mineral Research 9:1713-1722, 1994

13. Scully, SP, Temple, HT, O'Keefe, RJ, and Gebhardt, MC: Case report 830: Aneurysmal bone cyst. Skeletal Radiology 23 (2): 157-60, 1994

14. Puzas, JE, Hicks, DG, Reynolds, SD, and O'Keefe, RJ: Regulation of osteoclastic activity in infection. Methods in Enzymology 236:47-58, 1994

15. Scully, SP, Mott, MP, Temple, HT, O'Keefe, RJ, O'Donnell, RJ, and Mankin, HJ: Late recurrence of giant-cell tumor of bone: A report of four cases. Journal of Bone and Joint Surgery 76 (8): 1231-1233, 1994

16. Temple, HT, Scully, SP, O'Keefe, RJ, Rosenthal, DI, and Mankin, HJ: Clinical presentation of alveolar soft-part sarcoma. Clinical Orthopaedics and related research 300:213-218, 1994

17. Scully SP; Temple HT; O'Keefe RJ; Scarborough MT; Mankin HJ; Gebhardt MC. "Role of surgical resection in pelvic Ewing's sarcoma." Journal of clinical oncology: official journal of the American Society of Clinical Oncology. 13(9):2336-41. 1995

18. Hicks DG; Gokan T; O'Keefe RJ; Totterman SM; Fultz PJ; Judkins AR; Meyers SP; Rubens DJ; Sickel JZ; Rosier RN. "Primary lymphoma of bone. Correlation of magnetic resonance imaging features with cytokine production by tumor cells." Cancer 75(4):973-80. 1995

19. Rosier, RN, Teot, LA, Hicks, DG, Schwartz, C, O'Keefe, RJ, and Puzas, JE: Multiple drug resistance in osteosarcoma. The Iowa Orthopaedic Journal 15:66-73, 1995

20. O'Keefe, RJ, O'Connell, JX, Temple, HT, Scully, SP, Kattapuram, SV, Springfield, DS, Rosenberg, AE, and Mankin, HJ: Calcific myonecrosis: A late sequela to compartment syndrome of the leg. Clinical Orthopaedics and related research 318:205-213, 1995

22

21. O'Keefe, RJ, O'Donnell, RJ, Temple, HT, Scully, SP, and Mankin, HJ: Giant cell tumor of bone affecting the foot and ankle. Foot and Ankle 16:617-623, 1995

22. Hughes, SS, Hicks, DG, O'Keefe, RJ, Hurwitz, SR, Crabb, ID, Krasinskas, AM, Loveys, L, Puzas, JE, and Rosier, RN: Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus. Journal of Bone and Mineral Research 10 (4): 533-544, 1995

23. Blaine, TA, Rosier, RN, Puzas, JE, Looney, RJ, Reynolds, PR, Reynolds, SD, and O'Keefe, RJ: Increased levels of tumor necrosis factor-2 and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles. Journal of Bone and Joint Surgery 78A (8):1181-1192, 1996

24. Teot, LA, O'Keefe, RJ, Rosier, RN, O'Connell, J, Fox, EJ, Puzas, JE, and Hicks, DG: Extraosseous primary and recurrent giant cell tumors: Transforming growth factor-beta-1 and beta-2 expression may explain metaplastic bone formation. Human Pathology 27:625-632, 1996

25. Reynolds, SD, Johnston, C., Leboy, PS, O'Keefe, RJ, Puzas, JE, Rosier, RN, and Reynolds, PR: Identification and characterization of a unique chondrocyte gene involved in transition to hypertrophy. Experimental Cell Research 226:197-207, 1996

26. Scully, SP, Temple, HT, O'Keefe, RJ, Mankin, HJ, and Gebhardt, M: The surgical treatment of patients with osteosarcoma who sustain a pathologic fracture. Clinical Orthopaedics and related research 324:227-232, 1996

27. Delsignore, JL, Dvoretsky, PM, Hicks, DG, O'Keefe, RJ and Rosier, RN: Mastocytosis presenting as a skeletal disorder. The Iowa Orthopaedic journal 16:126-134, 1996

28. Reynolds, PR, Reynolds, SD, O'Keefe, RJ, Puzas, JE, and Rosier, RN: Alternative splicing of a chondrocyte-specific gene. Annals of the New York Academy Of Sciences 785:321-324, 1996

29. Hicks, DG, O'Keefe RJ, Reynolds, KJ, Cory-Slechta, DA, Puzas, JE, and Rosier, RN: Effects of lead on growth plate chondrocyte phenotype. Toxicology and. Applied Pharmacology 140:164-172, 1996

30. Hicks, DG, Judkins, AR, Sickel, JZ, Rosier, RN, Puzas, JE, and O'Keefe, RJ. Granular histiocytosis of pelvic lymph nodes following total hip arthroplasty. Journal of Bone and Joint Surgery 78A:482-496, 1996

31. Rosier, RN, O'Keefe, RJ, Teot, LA, Fox, EJ, Nester, TA, Schnell, J, Puzas, JE, Reynolds, PR, and Hicks, DG. P-glycoprotein expression in cartilaginous tumors. Journal of Surgery and Oncology 65:95-105, 1997

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32. O'Keefe, RJ, Teot, LA, Singh, D, Puzas, JE, Rosier, RN, and Hicks, DG: Osteoclasts constitutively express regulators of bone resorption. An immunohistochemical and in-situ hybridization study. Laboratory Investigation 76:457-465, 1997

33. O'Keefe, RJ, Loveys, LS, Hicks, DG, Reynolds, PR, Crabb, ID, Puzas, JE, and Rosier, RN. Differential regulation of type-II and type-X collagen synthesis by parathyroid hormone-related protein in chick growth plate chondrocytes. Journal of Orthopaedic Research 15 (2):162-74, 1997

34. Hicks, DG, Stroyer, BF, Teot, L.A, and O'Keefe, RJ: In-situ hybridization in skeletal tissues utilizing non-radioactive probes. Journal of Histotechnology 20:215-224, 1997

35. Blaine, TA, Pollice, PF, Rosier, RN, Reynolds, PR, Puzas, JE, and O'Keefe, RJ: Modulation of the production of cytokines in titanium stimulated human peripheral blood monocytes by pharmacological agents: The role of cAMP mediated signaling mechanisms. Journal of Bone and Joint Surgery 79A (10):1519-28, 1997

36. Rosier RN; O'Keefe RJ. "Autocrine regulation of articular cartilage." Instructional course lectures. 47:469-75. 1998

37. Grimsrud, C, Rosier, RN, Puzas, JE, Reynolds. PR, Reynolds, SD, Hicks, DG, and O'Keefe, RJ: BMP-7 in growth plate chondrocytes: Regulation by retinoic acid is dependent upon the stage of chondrocyte maturation. Journal of Orthopaedic Research 16:247-255, 1998

38. Romano, PR, Wang, J, O’Keefe, RJ, Puzas, JE, Rosier, RN, and Reynolds, PR: HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation. Journal of Cell Science 111:803-813, 1998

39. Rapoport, AP, Constine, LS, Packman, CH, Rosier, RN, O’Keefe, RJ, Hicks, DG,

Rubin, SJ, and Rowe, JM: Treatment of multifocal lymphoma of bone with intensified promace-cytabom chemotherapy and involved field radiotherapy. American Journal of Hematology 58:1-7, 1998

40. Guerra, CE, Betts, RF, O’Keefe, RJ, and Shilling, JW: Mycobacterium bovis osteomyelitis involving a hip arthroplasty after intravesicular Bacille Calmette-Guerin for bladder cancer. Clinical Infectious Diseases 27:639-640, 1998

41. O’Keefe, RJ, Rosier, RN, Teot, LA, Stewart, J.M.M, and Hicks, DG: Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. The Iowa Orthopaedic Journal 18:26-34, 1998

42. Pollice, PF, Hsu, J, Hicks, DG, Bukata, S, Rosier, RN, Reynolds, PR, Puzas, JE, and O’Keefe, RJ: IL-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: evidence of an anti-inflammatory regulatory pathway. Journal of Orthopaedic Research 16:697-704, 1998

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43. Serletti, JM, Carras, AJ, O’Keefe, RJ, and Rosier, RN: Functional outcome after soft-tissue reconstruction for limb salvage after sarcoma surgery. Plastic and Reconstructive Surgery 102(5): 1576-1583, 1998

44. Reynolds, SD, Zuscik, MJ, Gunter, TE, O’Keefe, RJ, Puzas, JE, Rosier, RN, and Reynolds, PR: Parathyroid hormone and parathyroid hormone-related peptide effects on growth plate chondrocytes: an overview. Cells and Materials 7 (4): 289-300, 1998

45. Rosier, RN, O’Keefe, RJ, and Hicks, DG: The potential role of transforming growth factor beta in fracture healing. Clinical Orthopaedics and related research 355S:S294-S300, 1998

46. Grimsrud, C, Romano, PM, Rosier, RN, Puzas, JE, Reynolds,.PR, and O'Keefe, RJ: BMP-6 is an autocrine stimulator of chondrocyte differentiation. Journal of Bone and Mineral Research 14:475-482, 1999

47. Chi, H, Tiller, GE, Dasouki, MJ, Romano, PR, Wang, J, O’Keefe, RJ, Puzas, JE,Rosier, R.N., and Reynolds, P.R.: Multiple inositol polyphosphate phosphatase: Evolutionas a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to 10q23 and 19. Genomics, 56:324-336, 1999

48. Vena, VE, Hsu, J., Rosier, RN, and O’Keefe, RJ. Pelvic reconstruction for severe periacetabular metastatic disease. Clinical Orthopaedics and related research 362:171-180, 1999

49. Temple, HT, Scully, SP, O'Keefe, RJ, Katapurum, S, and Mankin, HJ: Clinical outcome of 38 patients with juxtacortical osteosarcoma. Clinical Orthopaedics and related research 373:208-17, 2000

50. Schwarz, EM, Lu, AP, Goater, JJ, Benz, EB, Kollias, G, Rosier, RN, Puzas, JE, andO’Keefe, RJ: Tumor necrosis factor-alpha/nuclear transcription factor-kappa ß signaling in periprosthetic osteolysis. Journal of Orthopaedic. Research 18 (3):472-80, 2000

51. Goater, JJ, Müller, R, Kollias, G, Firestein, GS, Sanz, I, O’Keefe, RJ, and Schwarz,EM: Empirical advantages of adeno-associated viral vectors for in vivo gene therapy for arthritis. The Journal of Rheumatology 27 (4):983-9, 2000

52. Schwarz, EM, Benz, EB, Lu, AP, Goater, Mollano, AV, Rosier, RN, Puzas, JE, and O’Keefe, RJ: A quantitative small animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis. The Journal of Orthopaedic Research 18:849-55, 2000

53. Schwarz, E.M., Looney, R.J. and O’Keefe, RJ: Anti- TNFα therapy as a clinical intervention for periprosthetic osteolysis. Arthritis Research 2 (3):165-68, 2000

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54. Pateder, DB, Rosier, RN, Schwarz, EM, Reynolds, PR, Puzas, JE, D’Souza, M, and O’Keefe, RJ: PTHrP expression in chondrocytes, regulation by TGF-ß and interactions between epiphyseal and growth plate chondrocytes. Experimental Cell Research 256 (2):555-62, 2000

55. Reynolds, SD, Zhang, D, Puzas, JE, O'Keefe, RJ, Rosier, RN, and Reynolds, PR: Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues. Gene 248 (1-2):233-43, 2000

56. Ferguson, CM, Schwarz, EM, Reynolds, PR, Puzas, JE, Rosier, RN, and O’Keefe, RJ: Smad2 and 3 mediate TGF-ß1-induced inhibition of chondrocyte maturation. Endocrinology 141:4728-35, 2000

57. Rosier, RN, and O'Keefe, RJ: Hyaluronic acid therapy. Instructional Course Lectures 49:495-502, 2000

58. Li, P, Sanz, I, O'Keefe, RJ, and Schwarz, EM: NF-kappa ß regulates VCAM-1 expression on fibroblast-like synoviocytes. The Journal of Immunology 164 (11):5990-7, 2000

59. O’Keefe, RJ, Schwarz, EM, and Boyce, BF: Bone metastases: An update on mechanisms of bone resorption and therapeutic strategies. Current Opinion in Orthopaedics 11 (5):353-359, 2000

60. Schwarz, EM, and O’Keefe, RJ: Breakthrough in bone: The molecular mechanism of osteoclast/osteoblast coupling revealed. Current Opinion in Orthopaedics 11 (5):329-335, 2000

61. Chi, H, Yang, X, Kingsley, PD, O’Keefe, RJ, Puzas, JE, Rosier, RN, Shears, SB, and Reynolds, PR: Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo. Molecular and Cellular Biology 20 (17):6496-6507, 2000

62. Andela, VB, Schwarz, EM, Puzas, JE, O’Keefe, RJ, and Rosier, RN: Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor к ß. Cancer Research 60:6557-62, 2000

63. Grimsrud, CD, Romano, PR, D’Souza, M, Reynolds, PR, Puzas, JE, Rosier, RN, and O’Keefe, RJ: BMP signaling stimulates chondrocyte maturation and expression of Indian Hedgehog. The Journal of Orthopaedic Research 19 (1):18-25, 2001

64. Pollice, PF, Rosier, RN, Puzas, JE, Schwarz, EM, and O’Keefe, RJ: Oral pentoxifylline inhibits the release of tumor necrosis factor alpha from human peripheral blood monocytes: A potential treatment for aseptic loosening. The Journal of Bone and Joint Surgery 83:1057-1061, 2001

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65. Ionescu, AM, Schwarz, EM, Vinson, C, Puzas JE, Rosier, RN, Reynolds, PR, and O’Keefe, RJ: PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling. The Journal of Biological Chemistry 276 (15):11639-47, 2001

66. Childs, LM, Goater, JJ, O’Keefe, RJ, and Schwarz, EM: Efficacy of etanercept for wear debris-induced osteolysis. The Journal of Bone and Mineral Research 16:338-47, 2001

67. Zhang, X, Morham, SG, Langenbaach, R, Young, DA, Xing, L, Boyce, BF, Puzas, JE, Rosier, RN, O’Keefe, RJ, and Schwarz, EM: Evidence for a direct role of cyclooxygenase 2 in implant wear debris-induced osteolysis. The Journal of Bone and Mineral Research 16 (4):660-670, 2001

68. Pateder, DB, Ferguson, CM, Schwarz, E.M, Rosier, RN, Reynolds, PR, Puzas, JE, and O’Keefe, RJ: PTHrP expression in chick sternal chondrocytes is regulated by TGF-ß through Smad-mediated signaling. Journal of Cellular Physiology 188 (3):343-51, 2001

69. Childs, LM, Goater, JJ, O’Keefe, RJ, and Schwarz, EM: The effect of anti-tumor necrosis factor-α (TNFα) gene therapy on wear debris-induced osteolysis. The Journal of Bone and Joint Surgery 83:1789-97, 2001

70. Pateder, DB, Eliseev, RA, O'Keefe, RJ, Schwarz, EM, Okunieff, P, Constine, LS, Puzas, JE, and Rosier, RN: The role of autocrine growth factors in radiation damage to the epiphyseal growth plate. Radiation Research. 155 (6):847-57, 2001

71. Zhang, X, Zhang, Y, Schwarz, EM, and O’Keefe, RJ: Cyclooxygenase and bone repair. Current Opinion in Orthopaedics 12:397-402, 2001

72. Huang, W, O’Keefe, RJ, and Schwarz, EM: Gene polymorphisms and musculoskeletal disease. Current Opinion in Orthopaedics 12:416-23, 2001

73. Konttinen YT; Mandelin J; Li TF; Salo J; Lassus J; Liljeström M; Hukkanen M; Takagi M; Virtanen I; Santavirta S.; O'Keefe RJ. "Acidic cysteine endoproteinase cathepsin K in the degeneration of the superficial articular hyaline cartilage in osteoarthritis." Arthritis and rheumatism. 46(4):953-60. 2002

74. Paavonen K; Mandelin J; Partanen T; Jussila L; Li TF; Ristimaki A; Alitalo K; Konttinen YT. O'Keefe RJ "Vascular endothelial growth factors C and D and their VEGFR-2 and 3 receptors in blood and lymphatic vessels in healthy and arthritic synovium." The Journal of rheumatology 29(1):39-45. 2002

75. Mungo DV; Zhang X; O'Keefe RJ; Rosier RN; Puzas JE; Schwarz EM. "COX-1 and COX-2 expression in osteoid osteomas." Journal of orthopaedic research: official publication of The Orthopaedic Research Society 20(1):159-62, 2002

76. Looney, RJ, Boyd, A., Totterman, S, Seo, GS, Tamez-Pena, J, Campbell, D, Novotny, L., Olcott, C., Martell, J, Hayes, FA, O'Keefe, RJ, and Schwarz, EM: Volumetric

27

Computerized Tomography as a measurement of periprosthetic acetabular osteolysis and its correlation with wear. Arthritis Research 4 (1):59-63, 2002

77. Carmody, EE, Schwarz, EM, Puzas, JE, Rosier, RN, and O’Keefe, RJ: IL-10 gene therapy inhibits inflammation, osteoclastogenesis, and bone resorption in response to titanium particles. Arthritis Research 46 (5):1298-1308, 2002

78. Pateder, DB, Gish, MW, O’Keefe, RJ, Hicks, DG, Teot, L.A, and Rosier, RN: Parathyroid hormone related peptide expression in cartilaginous tumors correlates with malignancy. Clinical Orthopaedics and related research 403:198-204, 2002

79. Goater, JJ, O’Keefe, RJ, and Schwarz, EM. Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis. The Journal of Orthopaedic Research 20 (2):169-73, 2002

80. Puzas, JE, O’Keefe, RJ, and Lieberman, J: The orthopaedic genome: What does the future hold and what are we ready to deal with it. The Journal of Bone and Joint Surgery 84-A (1):133-41, 2002

81. Soloviev, A, Schwarz EM, Rosier RN, Reynolds PR, Puzas JE, and O’Keefe, RJ. The role of p105 protein in NFk ß activation in ANA-1 murine macrophages following stimulation with titanium particles. The Journal of Orthopaedic Research 20 (4):714-22, 2002

82. Zuscik, MJ, O’Keefe, RJ, Gunter, TE, Puzas, JE, Schwarz, EM, and Rosier, RN: Parathyroid hormone – related peptide regulation of chondrocyte maturation requires protein kinase A. The Journal of Orthopaedic Research 20 (5):1079-90, 2002

83. Zuscik, MJ, Pateder, DB, Puzas, JE, Schwarz, EM, Rosier, RN, and O'Keefe, RJ. Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappa ß signaling in chondrocytes. The Journal of Orthopaedic Research 20 (4):811-18, 2002

84. Andela, VB, Sheu, TJ, Puzas, EJ, Schwarz, EM, O'Keefe, RJ, and Rosier, RN: Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaß. Biochemical and Biophysical Research Communications 297:237-41, 2002

85. Good, CR, O’Keefe, RJ, Puzas, JE, Schwarz, EM, and Rosier, RN: An immunohistochemical study of receptor activator of nuclear factor Kappa ß ligand (RANK-L) in human osteolytic bone tumors. The Journal of Surgery and Oncology 79 (3):174-9, 2002

86. Pateder, DB, Sheu, TJ, O'Keefe, RJ, Puzas, JE, Schwarz, EM, Constine, LS, Okunieff, P, and Rosier, RN: Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes. Radiation Research 157(1):62-8, 2002

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87. Zhang, X, Schwarz, EM, Young, DA, Xing, L, Boyce, BF, Puzas, JE, Rosier, RN, and O’Keefe, RJ: Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. The Journal of Clinical Investigation 109 (11):1405-1415, 2002

88. Zuscik, MJ, D'Souza, M, Gunter, K.K, Gunter, TE, O'Keefe, RJ, Schwarz, EM, Puzas, JE, and Rosier, RN: Growth plate chondrocyte maturation is regulated by basal intracellular calcium. Experimental Cell Research 276:310-9, 2002

89. Sheu, TJ, Schwarz, EM, O'Keefe, RJ, Rosier, RN, and Puzas, JE: Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae. The Journal of Bone and Mineral Research 17 (5):915-22, 2002

90. Andela, VB, Rosenblatt, JD, Schwarz, EM, Puzas, JE, O'Keefe, RJ, and Rosier, RN: Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis. Clinical Orthopaedics and related research 397:228-39, 2002

91. Zhang, D, Ferguson, CM, O'Keefe RJ, Puzas, JE, Rosier, RN, and Reynolds, PR: A role for the BMP antagonist chordin in endochondral ossification. The Journal of Bone and Mineral Research 17 (2):293-300, 2002

92. Childs, LM, Paschalis, EP, Xing, L, Dougall, WC, Anderson, D, Boskey, AL, Puzas, JE, Rosier, RN, O'Keefe, RJ, Boyce, BF, and Schwarz, EM: In vivo RANK signaling blockade using the receptor activator of NF-kappa ß: Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. The Journal of Bone Mineral Research 17(2):192-9, 2002

93. O’Keefe, RJ: Determination of responsiveness in biological systems is dependent on highly sensitive quantitative measures. Annals of the New York Academy of Sciences 961:206, 2002

94. Guilak, F., Kapur, R, Sefton, MV, Vandenburgh, H, Koretsky, AP, Kriete, A, and O'Keefe, RJ: Functional assessment of engineered tissues and elements of tissue design: breakout session summary. Annals of the New York Academy of Sciences 961:207-09, 2002

95. Ulrich-Vinther, M, Maloney, M D, Goater, JJ, Soballe, K, Goldring, MB, O'Keefe, RJ, and Schwarz, EM: Light-activated gene transduction enhances adeno-associated virus vector-mediated gene expression in human articular chondrocytes. Arthritis Rheumatology 46 (8):2095-104, 2002

96. Ulrich-Vinther, M, Carmody, EE, Goater, JJ, Soballe, K, O'Keefe, RJ, and Schwarz, EM: Recombinant adeno-associated virus-mediated osteoprotegerin gene therapy inhibits wear debris-induced osteolysis. The Journal of Bone and Joint Surgery 84A (8):1405-12, 2002

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97. Ballock RT; O'Keefe RJ. "Physiology and pathophysiology of the growth plate." Birth defects research. Part C, Embryo today : reviews. 69(2):123-43. 2003

98. Huang W; Drissi MH; O'Keefe RJ; Schwarz EM. "A rapid multiparameter approach to study factors that regulate osteoclastogenesis: demonstration of the combinatorial dominant effects of TNF-alpha and TGF-ss in RANKL-mediated osteoclastogenesis." Calcified tissue international. 73(6):584-93. 2003

99. Huang, W, O'Keefe, RJ, and Schwarz, EM: Exposure to receptor-activator of NFkappa ß ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation. Arthritis Research and Therapy 5 (1):R49-59, 2003

100. Li, X, Ionescu, AM, Schwarz, EM, Zhang, X, Drissi, H, Puzas, JE, Rosier, RN, Zuscik, MJ, and O'Keefe, RJ: Smad6 is induced by BMP-2 and modulates chondrocyte differentiation. The Journal of Orthopaedic Research 21 (5):908-13, 2003

101. Li, X, Schwarz, EM, Zuscik, MJ, Rosier, RN, Ionescu, A.M, Puzas, JE, Drissi, H, Sheu, TJ, and O'Keefe, RJ: Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5. Endocrinology 144 (6):2514-23, 2003

102. Ionescu, AM, Schwarz, EM, Zuscik, MJ, Drissi, H, MJ, Puzas, JE, Rosier, RN, and O'Keefe, RJ: ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation. Experimental Cell Research 288 (1):198-207, 2003

103. Flick, L, Weaver, JM., Ulrich-Vinther, M, Abuzzahab, F, Zhang, X, Dougall, WC, Anderson, D, O'Keefe, RJ, and Schwarz, EM: Effects of receptor activator of NFkappa ß (RANK) signaling blockade on fracture healing. The Journal of Orthopaedic Research 21 (4):676-84, 2003

104. Andela, VB, Gingold, BI, Souza, MD, O'Keefe, RJ, Puzas, EJ, Schwarz, EM, and Rosier, RN: Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappa ß. Cancer Letters 194 (1):37-43, 2003

105. Ballock, RT., and O'Keefe, RJ: The biology of the growth plate. The Journal of Bone and Joint Surgery 85A (4):715-26, 2003

106. Sheu, TJ, Schwarz, EM, Martinez, DA, O'Keefe, RJ, Rosier, RN, Zuscik, MJ, and Puzas, JE: A phage display technique identifies a novel regulator of cell differentiation. The Journal of Biological Chemistry 278 (1):438-43, 2003

107. Andela, VB, Gordon, AH, Zotalis, G, Rosier, RN, Goater, JJ, Lewis, G.D, Schwarz, EM, Puzas, JE, and O’Keefe, RJ: NFKappa ß: A pivotal transcription factor in prostate cancer metastasis to bone. Clinical Orthopaedics and related research 415:S75-85, 2003

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108. Andela, VB, Pirri M, Schwarz, EM, Puzas, JE, O’Keefe, RJ, Rosenblatt, JD, and Rosier, RN: The mevalonate synthesis pathway as a therapeutic target in cancer. Clinical Orthopaedics and related research 415 S:S59-66, 2003

109. O’Keefe, RJ, and Guise, TA: Molecular mechanisms of bone metastasis and therapeuticimplications. Clinical Orthopaedics and related research 415 S:S100-04, 2003

110. Zhang, D, Schwarz, EM, Rosier, RN, Zuscik, MJ, Puzas, JE, and O’Keefe, RJ: ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. The Journal of Bone and Mineral Research 18 (9):1 593-604, 2003

111. Ulrich-Vinther, M, Maloney, M.D, Schwarz, EM, Rosier, R, and O'Keefe, RJ: Articular cartilage biology. The Journal of the American Academy of Orthopaedic Surgeons 11 (6):421-430, 2003

112. Bukata, SV, Gelinas, J, Wei, X, Rosier, RN, Puzas, JE, Zhang, X, Schwarz, EM, Song, XR, Griswold, DE, and O'Keefe, RJ: PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway. The Journal of Orthopaedic Research 22 (1):6-12, 2003

113. Drissi, M.H., Li, X., Sheu, T.J., Zuscik, M.J., Schwarz, E.M., Puzas, J.E., Rosier, R.N., and O'Keefe, RJ: Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes. The Journal of Cellular Biochemistry. 90 (6):1287-98, 2003

114. Schwarz, EM, Campbell, D, Totterman, S, Boyd, A, O'Keefe, RJ, and Looney, RJ: Use

of volumetric computerized tomography as a primary outcome measure to evaluate drug efficacy in the prevention of peri-prosthetic osteolysis: A 1-year clinical pilot of etanercept vs. placebo. The Journal of Orthopaedic Research 21 (6):1049-55, 2003

115. Puzas, JE, O’Keefe, RJ, Schwarz, EM, and Zhang, X: Pharmacologic modulators of fracture healing: The role of cyclooxygenase inhibition. Journal of Musculoskeletal Neuronal Interactions 3 (4):308-312, 2003

116. Ito, H, Goater, JJ, Tiyapatanaputi, P, Rubery, PT, O'Keefe, RJ, and Schwarz, EM: Light-activated gene transduction of recombinant adeno-associated virus in human mesenchymal stem cells. Gene Therapy. 11 (1):34-41, 2004

117. Li, P, Schwarz, EM, O’Keefe, RJ, Ma, L, Looney, RJ, Ritchlin, CT, Boyce, BF, and Xing, L: Systemic tumor necrosis factor α mediates an increase in peripheral CD11bhigh osteoclast precursors in tumor necrosis factor alpha-transgenic mice. Arthritis and Rheumatology 50 (1):265-276, 2004

118. Ionescu, AM, Drissi H, Schwarz, E.M, Kato, M, J. Puzas, JE, McCance, DJ, Rosier,

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RN, Zuscik, MJ, and O’Keefe, RJ: CREB cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter. Journal of Cellular Physiology 198 (3):428-440, 2004

119. Li, P, Schwarz, EM, O’Keefe, RJ, Ma, L, Boyce, BF, and Xing, L: RANK signaling is not required for TNF alpha-mediated increase in CD11bhi osteoclast precursors but is essential for mature osteoclast formation in TNF alpha-mediated inflammatory arthritis. The Journal of Bone and Mineral Research 19 (2):207-213, 2004

120. Bukata, SV, Gelinas, J, Wei, X, Rosier, RN, Puzas, JE, Zhang, X, Schwarz, EM, Song, XR, Griswold, DE, and O’Keefe, RJ: PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway. The Journal of Orthopaedic Research 22:2-12, 2004

121. Zuscik, MJ, Baden, JF, Wu, Q, Sheu, TJ, Schwarz, E.M, Drissi, H, O’Keefe, RJ, Puzas, JE, and Rosier, RN: 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes. Journal of Cellular Biochemistry 92 (2):316-31, 2004

122. Zhang, X, Ziran, N, Goater, JJ, Schwarz, E.M, Puzas, JE, Rosier, RN, Zuscik, MJ, Drissi, H, and O’Keefe, RJ: Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PBGE2 inhibits terminal differentiation. Bone 34: 909-817, 2004

123. Ferguson, CM, Schwarz, EM, Puzas, JE, Zuscik, MJ, Drissi, MH, and O’Keefe, RJ: Transforming growth factor – beta1 induced alteration of skeletal morphogenesis in vivo. The Journal of Orthopaedic Research 22 (4):687-96, 2004

124. Ritchlin, CT, Schwarz, EM, O’Keefe, RJ, and Looney, RJ.: RANK, RANKL and OPG in inflammatory arthritis and periprosthetic osteolysis. Journal of Musculoskeletal Neuronal Interactions, 4 (3):276-284, 2004

125. Ulrich-Vinther, M, Duch, MR, Soballe, K, O’Keefe, RJ, Schwarz, EM, and Pedersen, FS: In vivo gene delivery to articular chondrocytes mediated by an adeno-associated virus vector. The Journal of Orthopaedic Research 22 (4):726-34, 2004

126. Schwarz, EM, O’Keefe, RJ, and Looney, RJ: Bone implant interface, osteolysis and potential therapies. Journal of Musculoskeletal Neuronal Interactions 4 (4):390-392, 2004

127. Li, TF, Dong, Y, Ionescu, AM, Rosier, RN, Zuscik, MJ, Schwarz, EM, O’Keefe, RJ, and Drissi, H: Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. Experimental Cell Research 299: 128-136, 2004

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128. Li, TF, Zuscik, MJ, Ionescu, AM, Zhang, X, Rosier, RN, Schwarz, EM, Drissi, H, and O’Keefe, RJ: PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling. Experimental Cell Research 300 (1):159-169, 2004

129. Tiyapatanaputi, P, Rubery, PT, Carmouche, J, Schwarz, EM, O’Keefe, RJ, and Zhang,X. A novel murine segmental femoral graft model: Journal of Orthopaedic Research 22 (6):1254-1260, 2004

130. Guldberg, RE, Oest, M, Lin, ASP, Ito, H, Chao, S, Gromov, K, Goater, JJ, Koefoed, M, Schwarz, EM, O’Keefe, RJ, and Zhang, X: Functional integration of tissue- engineered bone constructs. Journal of Musculoskeletal and Neuronal Interactions 4 (4):399-400, 2004

131. O’Keefe, RJ, and Rubery, PT: Point of View. Spine 30 (1):31-32, 2005

132. Li, T, O’Keefe, RJ, and Chen, D: TGF- Beta signaling in chondrocytes. Frontiers in Bioscience 10: 681-688, 2005

133. Blaine, TA, Kim, YS, Voloshin, I, Chen, D., Murakami, K, Chang, SS, Winchester, R, Lee, F.Y., O’Keefe, RJ, and Bigliani, L.U.: The molecular pathophysiology of subacromial bursitis in rotator cuff disease. Journal of Shoulder and Elbow Surgery 14 (1S):84S-89S, 2005

134. Ito, H, Koefoed, M, Tiyapatanaputi, P, Gromov, K, Goater, JJ, Carmouche, J, Zhang, X, Rubery, PT, Rabinowitz, J, Samulski, RJ, Nakamura, T, Soballe, K, O’Keefe, RJ, Boyce, BF, and Schwarz, EM: Remodeling of cortical bone allografts mediated by adherent rAAV-RANKL and VEGF gene therapy. Nature Medicine 11 (3):291-297, 2005

135. Clark, CA, Zuscik, MJ, Zhang, X, Ziran, NM, Drissi, H, Schwarz, EM, and O’Keefe, RJ: Differential regulation of EP receptor isoforms during condrogenesis and chondrocyte maturation. Biochemical and Biophysical Research Communications 328: 764-776, 2005

136. Gordon, AH, O’Keefe, RJ, Schwarz, EM, Rosier, RN, and Puzas, JE: Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone. Cancer Research 65 (6):3209-17, 2005

137. Soloviev, A, Schwarz, EM, Darowish, M and O’Keefe, RJ: Sphingomyelinase mediates macrophage activation by titanium particles independent of phagocytosis: A role for free radicals, NFkappaB, and TNFalpha. The Journal of Orthopaedic Research 23 (6):1258-65, 2005

138. Dong, Y, Drissi, H, Chen, M, Chen, D. Zuscik, MJ, Schwarz, EM, and O’Keefe, RJ: Wnt-mediated regulation of chondrocyte maturation: Modulation by TGF-beta. Journal of Cellular Biochemistry 95:1057-68, 2005

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139. Drissi, H, Zuscik, M, Rosier, R, and O’Keefe, RJ: Transcriptional regulation of chondrocyte maturation: Potential involvement of transcription factors in OA pathogenesis. Molecular Aspects of Medicine 26:169-179, 2005

140. Carmouche, JJ, Puzas, JE, Zhang, X, Tiyapatanaputi, P, Cory-Slechta, DA, Gelein, R, Zuscik, M, Rosier, RN, Boyce, BF, O’Keefe, RJ, and Schwarz, EM: Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environmental Health Perspectives 113 (6):749-755, 2005

141. Wei, X, Zhang, X, Zuscik, MJ, Drissi, MH, Schwarz, EM, and O’Keefe, RJ: Fibroblasts express RANKL and support osteoclastogenesis in a COX-2 dependent manner after stimulation with titanium particles. The Journal of Bone and Mineral Research 20 (7):1136-48, 2005

142. Koefoed, M., Ito, H, Gromov, K, Awad, HA, Rubery, PT, Ulrich-Vinther, M, Soballe, K, Guldberg, RE, Lin, AS, O’Keefe, RJ, and Schwarz, EM: Biological effects of rAAV-caAlk2 coating on structural allograft healing. Molecular Therapy 12(2):212-8, 2005

143. Wang, Y, Belflower, RM, Dong, YF, Schwarz, EM, O’Keefe, RJ, and Drissi, H: Runx1/AML1/Cbfa2 mediates onset of mesenchymal cell differentiation toward chondrogenesis. The Journal of Bone and Mineral Research 20 (9):1624-36, 2005

144. Voloshin,I, Gelinas J, Maloney MD, O'Keefe, RJ, Bigliani LU, and Blaine TA: Proinflammatory cytokines and metalloproteases are expressed in the subacromial bursa in patients with rotator cuff disease. The Journal of Arthroscopic and Related Surgery 21 (9):1076-1076, 2005

145. Eliseev, RA, Zuscik, MJ, Schwarz, EM, O'Keefe, RJ, Drissi, H, and Rosier, RN: Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: A role for c-Jun N-terminal kinase. Journal of Cellular Biochemistry 96-6:1262-73, 2005

146. Boyce, BF, Li, P, Yao, Z, Zhang, Q, Badell, IR, Schwarz, EM, O'Keefe, RJ, and Xing, L: TNF-alpha and pathologic bone resorption. The Keio Journal of Medicine 54 (3):127-31, 2005

147. Zhang, X, Xie, C, Lin, AS, Ito, H, Awad, H, Lieberman, JR, Rubery, PT, Schwarz, EM, O'Keefe, RJ, and Guldberg, RE: Periosteal progenitor cell fate in segmental cortical bone graft transplantations: implications for functional tissue engineering. The Journal of Bone and Mineral Research 20 (12):2124-37, 2005

148. Andela, VB, Schwarz, EM, O'Keefe, RJ, Puzas, EJ, Rosenblatt, JD, and Rosier, RN: A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival. FEBS Letters 579 (30):6814-6820, 2005

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149. Zhang, X, Naik, A, Xie, C, Reynolds, D, Palmer, J, Lin, A, Awad, H, Guldberg, R, Schwarz, EM, and O'Keefe, RJ: Periosteal stem cells are essential for bone revitalization and repair. Journal of Musculoskeletal Neuronal Interactions 5 (4):360-2, 2005

150. O'Keefe, RJ: Summary - cell therapies for orthopedic applications. Journal of Musculoskeletal Neuronal Interactions 5 (4):367-8, 2005

151. Smith, N, Dong, Y, Lian, JB, Pratap, J, Kingsley, PD, VanWijnen, AJ, Stein, JL, Schwarz, EM, O'Keefe, RJ, Stein, GS, Drissi, MH: Overlapping Expression of Runx1 (Cbfa2) and Runx2 (Cbfa1) Transcription Factors Supports Cooperative Induction of Skeletal Development. Journal of Cellular Physiology 203:133-143, 2005

152. Xie,C.; Reynolds,D.; Awad,H.; Rubery,P. T.; Pelled,G.; Gazit,D.; Guldberg,R. E.; Schwarz,E. M.; O'Keefe,R. J.; Zhang,X.;. "Structural Bone Allograft Combined with Genetically Engineered Mesenchymal Stem Cells As a Novel Platform for Bone Tissue Engineering". Tissue Engineering 2006

153. Shen, R, Chen, M, Wang, YJ, Kaneki, H, Xing, L, O'Keefe, RJ, and Chen, D: Smad6 interacts with Runx2 and mediates Smad ubiquitin regulator factor1-induced Runx2 degradation. The Journal of Biological Chemistry 281 (6):3569-76, 2006

154. O’Keefe, RJ, Tiyapatanaputi, P, Xie, C, Fang Li, T, Clark, C, Zuscik, MJ, Chen, D, Drissi, H., Schwarz, EM, and Zhang, X: COX-2 has a critical role during incorporation of structural bone allografts. Annals of the New York Academy of Sciences 1068:532-42, 2006

155. Looney, RJ, Schwarz, EM, Boyd, A, and O'Keefe, RJ: Periprosthetic osteolysis: an immunologist's update. Current Opinion in Rheumatology 18 (1):80-87, 2006

156. Li, TF, Darowish, M, Zuscik, MJ, Chen, D, Schwarz, EM, Rosier, RN, Drissi, H, and O'Keefe, RJ: Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. The Journal of Bone and Mineral Research 21:4-16, 2006

157. Eliseev, RA, Schwarz, EM, Zuscik, MJ, O'Keefe, RJ, Drissi, H, and Rosier, RN: Smad7mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. Experimental Cell Research 312:40-50, 2006

158. Maloney, MD, Goater, JJ, Parsons, R., Ito, H., O’Keefe, RJ, Rubbery, PT, Drissi, MH, and Schwarz, EM: Safety and efficacy of ultraviolet-A light-activated gene transduction for gene therapy of articular cartilage defects. The Journal of Bone and Joint Surgery 88:753-761, 2006

159. Shen, R, Wang, W, Drissi, H, Liu, F, O’Keefe, RJ, and Chen, D: Cyclin D1-cdk4 induce Runx2 ubiquitination and degradation. The Journal of Biological Chemistry 281 (24):16,347-53, 2006

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160. Dong, Y, Soung, DY, Schwarz, EM, O’Keefe, RJ, and Drissi, H: Wnt induction of chondrocyte hypertrophy through the Runx2 transcription factor. Journal of Cellular Physiology 208:77-86, 2006

161. Nishio,Y, Dong,Y, Paris, M, O’Keefe, RJ, Schwarz, EM and Drissi, MH: Runx2-mediated Regulation of the Zinc Finger Osterix/Sp7. Gene 372: 62-70, 2006

162. Li, TF, Chen, D, Wu, Q, Sheu, T, Schwarz, EM, Drissi, H, Zuscik, MJ. and O’Keefe, RJ: TGF- Stimulates Cyclin D1 Expression through activation of -catenin signaling in chondrocytes. The Journal of Biological Chemistry 281 (30):21,296-304, 2006

163. Schwarz, EM, Looney, RJ, Drissi, MH, O’Keefe, RJ, Boyce, BF, Xing, L. and Ritchlin, CT: Autoimmunity and bone. Annals of the New York Academy of Sciences 1068:275-283, 2006

164. Robertson, G, Xie, C, Chen, D, Awad, H, Schwarz, EM, O’Keefe, RJ, Guldberg, R.E. and Zhang, X. Alteration of femoral bone morphology and density in COX-2-/- mice. Bone 39:767-72, 2006

165. Baumhauer, JF, O’Keefe, RJ, Schon, LC and Pinzur, MS: Cytokine-induced osteoclastic bone resorption in Charcot Arthropathy: An immunohistochemical study. Foot and Ankle International 10:797-800, 2006

166. O’Keefe, RJ, Leach, JK, McDevitt, CA: On the horizon from the ORS. Journal of American Academy of Orthopaedic Surgery 14 (10):629-31, 2006

167. Xie, C, Reynolds, D, Awad, H, Rubery, PT, Pelled, G., Gazit, D., Guldberg, RE, Schwarz, E.M., O’Keefe, RJ, Zhang, X. Structural bone allograft combined with genetically engineered mesenchymal stem cells as a novel platform for bone tissue engineering. Tissue Engineering 13 (3):435-45, 2007

168. Chen M, Lichtler AC, Sheu TJ, Xie C, Zhang X, O’Keefe RJ, Chen, D. Generation of a transgenic mouse model with chondrocyte-specific and tamoxifen-inducible expression of Cre recombinase. Genesis 45:44-50, 2007

169. Wang Q, Wei X, Zhu T, Zhang M, Shen R, Xing L, O'Keefe RJ, Chen D. Bone morphogenetic protein 2 activates Smad6 gene transcription through bone-specific transcription factor Runx2. The Journal of Biological Chemistry 282 (14):10742-8, 2007

170. Awad HA, Zhang X, Reynolds DG, Guldberg RE, O'Keefe RJ, Schwarz EM. Recent Advances in Gene Delivery for Structural Bone Allografts: A Review. Tissue Engineering 13 (8): 1973-85, 2007

171. Reynolds DG, Hock C, Shaikh S, Jacobson J, Zhang X, Rubery PT, Beck CA, O'Keefe RJ, Lerner AL, Schwarz EM, Awad HA. Micro-computed tomography prediction of

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biomechanical strength in murine structural bone grafts. Journal of Biomechanics 40 (14):3178-86, 2007

172. Soung do Y, Dong Y, Wang Y, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H.Runx3/AML2/Cbfa3 Regulates Early and Late Chondrocyte Differentiation. The Journal of Bone and Mineral Research 22 (8):1260-70, 2007

173. Zuscik MJ, Ma L, Buckley T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ. Lead induces chondrogenesis and alters transforming growth factor-beta and bone morphogenetic protein signaling in mesenchymal cell populations. Environmental Health Perspectives 115 (9):1276-82, 2007

174. Dao DY, Yang X, Chen D, Zuscik M, O'Keefe RJ. Axin1 and Axin2 are regulated by TGF- and mediate cross-talk between TGF- and Wnt signaling pathways. Annals of the New York Academy of Sciences 15:82-99, 2007

175. Dong YF, Soung do Y, Chang Y, Enomoto-Iwamoto M, Paris M, O'Keefe RJ, Schwarz EM, Drissi H. Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner. Molecular Endocrinology 21 (11):2805-20, 2007

176. Zhu M; Chen M; Lichtler AC; O'Keefe RJ; Chen D. "Tamoxifen-inducible Cre-recombination in articular chondrocytes of adult Col2a1-CreER(T2) transgenic mice." Osteoarthritis and cartilage / OARS, Osteoarthritis Research Society. 16(1):129-30, 2008

177. Li D, Gromov K, Soballe K, Puzas JE, O'Keefe RJ, Awad H, Drissi H, Schwarz EM. Quantitative mouse model of implant-associated osteomyelitis and the kinetics of microbial growth, osteolysis, and humoral immunity. The Journal of Orthopaedic Research 26 (1): 96-106, 2008

178. Usui M, Xing L, Drissi H, Zuscik M, O'Keefe RJ, Chen D, Boyce BF Murine and Chicken Chondrocytes Regulate Osteoclastogenesis by Producing RANKL in Response to BMP2. The Journal of Bone and Mineral Research 23 (3): 314-325, 2008

179. Wu Q, Chen D, Zuscik MJ, O'Keefe RJ, Rosier RN. Overexpression of Smurf2 Stimulates Endochondral Ossification Through Upregulation of beta-Catenin. The Journal of Bone and Mineral Research 26 (5):704-712, 2008

180. Kaback LA, Soung DY, Naik A, Smith N, Schwarz EM, O'Keefe RJ, Drissi H. Osterix/Sp7 regulates mesenchymal stem cell mediated endochondral ossification. Journal of Cellular Physiology. 214 (1):173-82, 2008

181. Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN.-Regulation of embryonic endochondral ossification by Smurf2. The Journal of Orthopaedic Research 26 (5): 704-712, 2008

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182. Basile P, Dadali T, Jacobson J, Hasslund S, Ulrich-Vinther M, Søballe K, Nishio Y, Drissi MH, Langstein HN, Mitten DJ, O'Keefe RJ, Schwarz EM, Awad HA. Freeze-dried Tendon Allografts as Tissue-engineering Scaffolds for Gdf5 Gene Delivery. Molecular Therapy 16 (3): 466-473, 2008

183. Hasslund S, Jacobson JA, Dadali T, Basile P, Ulrich-Vinther M, Schwarz EM, O'Keefe RJ, Mitten DJ, Awad HA. Adhesions in a murine flexor tendon graft model: Autograft versus allograft reconstruction. The Journal of Orthopaedic Research 26 (6): 824-33, 2008

184. Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ , Rosier RN, Drissi MH. -Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene 27: 3605-14, 2008

185. Xie C, Xue M, Wang Q, Schwarz EM, O'Keefe RJ, Zhang X. Tamoxifen-inducible CreER-mediated gene targeting in periosteum via bone-graft transplantation. The Journal of Bone and Joint Surgery 90 Suppl 1:9-13, 2008

186. Zuscik MJ, Hilton MJ, Zhang X, Chen D, O'Keefe RJ. Regulation of chondrogenesis and chondrocyte differentiation by stress. The Journal of Clinical Investigation 118: 429-38, 2008

187. Chen M, Zhu M, Awad H, Li TF; Sheu TJ, Boyce BF, Chen D, O'Keefe RJ. Inhibition of (beta)-catenin signaling causes defects in postnatal cartilage development. Journal of Cell Science 21; (Pt 9):1455-65, 2008

188. Xie C, Ming X, Wang Q, Schwarz EM, Guldberg RE, O’Keefe RJ, Zhang X. COX-2 from the injury milieu is critical for the initiation of periosteal progenitor cell mediated bone healing. Bone 43 (6): 1075-83, 2008

189. Tsutsumi R, Hock C, Bechtold CD, Proulx ST, Bukata SV, Ito H, Awad H, Nakamura T, O'Keefe RJ, Schwarz, EM. Differential effects of biologic versus bisphosphonate inhibition of wear debris-induced osteolysis assessed by longitudinal micro-CT. The Journal of Orthopaedic Research 26 (10):1340-6, 2008

190. Kaback, LA, Soung DY, Naik A, Geneau G, Schwarz EM, Rosier RN, O’Keefe, RJ, Drissi, H. Teriparatide (1-34 human PTH) regulation of osterix during fracture repair. Journal of Cellular Biochemistry 1:105: (1):219-26, 2008

191. Zhang X, Awad, HA, O’Keefe, RJ, Guldberg, RE, Schwarz, EM. A perspective: engineering periosteum for structural bone graft healing. Clinical Orthopaedics and Related Research 466: 1777-87, 2008

192. Bostrom M, O'Keefe RJ. What experimental approaches (eg, in vivo, in vitro, tissue retrieval) are effective in investigating the biologic effects of particles? The Journal of the American Academy of Orthopaedic Surgeons 16 Suppl 1:S63-67, 2008

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193. Wu Q, Kim KO, Sampson ER, ChenD, Awad H, O’Brien T, Puzas JE, Drissi H, Schwarz EM, O’Keefe RJ, Zuscik, MJ, Rosier RN. Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. Arthritis and Rheumatism 58 (10): 3132-44, 2008

194. Wu, W; Huang, JH; Sampson, ER; Kim, KO; Zuscik, MJ; O'Keefe, RJ; Chen, D; Rosier, RN. "Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage". Experimental Cell Research 315(14): 2386-98, 2009

195. Clark CA, Li RF, Kim KO, Drissi H, Zuscik MJ, Zhang X, O’Keefe RJ. Prostaglandin E2 inhibits BMP signaling and delays chondrocyte maturation. The Journal of Orthopaedic Research 27(6):785-92, 2009

196. Loiselle AE, Bragdon GA, Jacobson JA, Hasslund S, Cortes ZE, Schwarz EM, Mitten DJ, Awad HA, O’Keefe RJ. Remodeling of murine intravnovial tendon adhesions following injury; MMP and neotendon gene expression. The Journal of Orthopaedic Research 27(6):833-40, 2009

197. Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik MJ, Chen D. Activation of beta-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult beta-Catenin Conditional Activation Mice. The Journal of Bone and Mineral Research 24(1):12-21, 2009

198. Crane DP, Gromov K, Li D, Soballe K, Wahnes C, Buchner H, Hilton MJ, O’Keefe RJ, Murray CK, Schwarz EM. Efficacy of colistin-impregnated beads to prevent multidrug-resistent A. baumannii implant-associated osteomyelitis. The Journal of Orthopaedic Research (8):1008-15, 2009

199. Naik AA, Xie C, Zuscik MJ, Kingsley P, Schwarz EM, Awad H, Guldberg, R, Drissi H, Puzas JE, Boyce B, Zhang X, O’Keefe RJ. Reduced COX-2 expression in aged mice is associated with impaired fractured healing. The Journal of Bone and Mineral Research 24 (2): 251-64, 2009

200. Reynolds DG, Shaikh S, Papuga MO, Lerner AL, O’Keefe RJ, Schwarz EM, Awad HA. muCT-based measurement of cortical bone graft-to-host union. The Journal of Bone and Mineral Research 24 (5): 899-907, 2009

201. Taylor DK, Meganck JA, Terkhorn S, Rajani R, Naik A, O’Keefe RJ, Goldstein SA, Hankenson KD. Thrombospondin-2 influences the proportion of cartilage and bone during fracture healing. The Journal of Bone and Mineral Research 24 (6): 1043-54, 2009

202. Tsutsumi R, Xie, C, Wei X, Zhang X, Flick LM, Schwarz EM, O’Keefe RJ. PGE2 signaling through the EP4 Receptor on fibroblasts upregulates RANKL and stimulates osteolysis. The Journal of Bone and Mineral Research 24 (10): 1753-62, 2009

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203. Darowish M. Rahman R. Li P, Bukata SV, Gelinas J, Huang W, Flick LM, Schwarz EM, O’Keefe RJ. Reduction of particle-induced osteolysis by interleukin-6 involves anti- inflammatory effect and inhibition of early osteoclast precursor differentiation. Bone. 45(4):661-8, 2009

204. Xie C, Liang B, Xue M, Lin AS, Loiselle A, Schwarz EM, Guldberg RE, O’Keefe RJ, Zhang X. Rescue of impaired fracture healing in COX-2-/- mice via activation of prostaglandin E2 receptor subtype 4. The American Journal of Pathology 175 (2): 772-85, 2009

205. Wei X, Zhang X, Flick LM, Drissi H, Schwarz EM, O’Keefe RJ. Titanium particles stimulate COX-2 expression in synolvial fibroblasts through an oxidative stress- induced, calpain-dependent, NF-Kappa B pathway. American Journal of Physiology 297 (2):C310-20, 2009

206. Frisch BJ, Porter RL, Gigliotti BJ, Olm-Shipman AJ, Weber JM, O'Keefe RJ, Jordan CT, Calvi LM. In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells. Blood 114-19:4054-63, 2009

207. Yan Y, Tang D, Chen M, Huang J, Xie R, Jonason JH, Tan X, Hou W, Reynolds D, Hsu W, Harris SE, Puzas JE, Awad H, O'Keefe RJ, Boyce BF, Chen D. Axin2 controls bone remodeling through the beta-catenin-BMP signaling pathway in adult mice. Journal of Cell Science 122-Pt 19:3566-78, 2009

208. Guise, TA, O'Keefe, RJ, Randall, RL, Terek, RM.: Molecular biology and therapeutics in musculoskeletal oncology. The Journal of Bone and Joint Surgery 91:724-32, 2009

209. Shane E, Burr D, Ebeling PR, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster D, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Koval K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe R, Papapoulos S, Sen HT, van der Meulen MC, Weinstein RS, Whyte M; American Society for Bone and Mineral Research. "Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research." Journal of Bone and Mineral Research. 2010; 25(11): 2267-94

210. Li D, Gromov K, Proulx ST, Xie C, Li J, Crane DP, Soballe K, O'Keefe RJ, Awad HA, Xing L, Schwarz EM. Effects of anti-resorptive agents on osteomyelitis: Novel insights on osteonecrosis of the jaw (ONJ) pathogenesis. Annals of the New York Academy of Sciences 1192(1):84-95, 2010

211. Gunnell, LM, Jonason, JH, Loiselle, AE, Kohn, A, Schwarz, EM, Hilton, M J. O'Keefe, RJ. TAK1 regulates cartilage and joint Development via the MAPK and BMP Signaling pathways. The Journal of Bone and Mineral Research 25 (8): 1784-97, 2010

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212. Dao DY, Yang X, Flick LM, Chen D, Hilton MJ, O’Keefe RJ. Axin2 regulates chondrocyte maturation and axial skeletal development. The Journal of Orthopaedic Research 28(1):89-95, 2010

213. Dong Y, Jesse AM, Kohn A, Gunnell LM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ. RBPj(kappa)-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. Development 137 (9):1461-71, 2010

214. Yanoso-Scholl L, Jacobson JA, Bradica G, Lerner AL, O'Keefe RJ, Schwarz EM, Zuscik MJ, Awad HA. Evaluation of dense polylactic acid/beta-tricalcium phosphate scaffolds for bone tissue engineering. Journal of Biomedical Materials Research 2010

215. Li TF, Gao L, Sheu RJ, Sampson ER, Flick LM, Konttinnen YR, Chen D. Schwarz EM, Zuscik MJ, Jonason JH, O’Keefe RJ. Aberrant hypertrophy in Smad3-deficient murine chondrocytes is rescued by restoring transforming growth factor beta-activated kinase 1/activating transcription factor 2 signaling: a potential clinical implication for osteoarthritis Arthritis and Rheumatism 62 (8):2359-69, 2010

216. Wu Q, Zhu M, Rosier RN, Zuscik MJ, O’Keefe RJ, Chen D. Beta-catenin, cartilage, and osteoarthritis. Annals of the New York Academy of Sciences Mar;1192:344-50, 2010

217. Katzel EB, Koltz PF, Tierney R, Williams JP, Awad HA, O’Keefe RJ, Langstein HN. A novel animal model for studying silicone gel-related capsular contracture. Plastic Reconstructive Surgery, 126(5):1483-91, 2010

218. Bukata SV, Kates, SL, O’Keefe, RJ. Short-term and Long-term Orthopaedic Issues in Patients with Fagility Fractures. Clinical Orthopaedics and Related Research Jan 29 2011

219. Jacobson JA, Yanoso-Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas EJ, Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz EM, Awad HA. "Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects." Tissue Engineering: Part A. 17(3-4): 389-98, February 2011

220. Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O’Keefe RJ. EP1-/- mice have enhanced osteoblast differentiation and accelerated fracture repair. Journal of Bone and Mineral Research 26:792-802, 2011

221. Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D, O'Keefe RJ, Rosier RN, Zuscik MJ. Establishment of an index with increased sensitivity for assessing murine arthritis. Journal of Orthopaedic Research Mar 3 2011

222. Reynolds DG, Takahata M, Lerner AL, O'Keefe RJ, Schwarz EM, Awad HA. "Teriparatide therapy enhances devitalized femoral allograft osseointegration and biomechanics in a murine model." Bone; 48(3): 562-70, March 2011

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223. Sampson ER, Amin V, Schwarz, EM, O’Keefe, RJ, Rosier, RN. The histone deacetylase inhibitor vorinostate selectively sensitizes fibrosarcoma cells to chemotherapy. Journal of Orthopaedic Research. 29 (4): 623-32, April 2011

224. Zhang M, Ho HC, Sheu TJ, Breyer MD, Flick LM, Jonason JH, Awad HA, Schwarz EM, O'Keefe RJ. "EP1(-/-) mice have enhanced osteoblast differentiation and accelerated fracture repair." The Journal of Bone and Mineral Research; 26(4): 792-802, April 2011

225. Kung, MH, Yukata, K, O’Keefe RJ, Zuscik, MJ. Aryl Hydrocarbon Receptor-Mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a) pyrene. Journal of Cell Physiology, May 12 2011

226. Katzel EB, Wolenski M, Loiselle AE, Basile P, Flick LM, Langstein HN, Hilton MJ, Awad HA, Hammert WC, O'Keefe RJ. "Impact of Smad3 loss of function on scarring and adhesion formation during tendon healing." The Journal of Orthopaedic Research. 29(5): 684-93, May 2011

227. Takahata M, Awad, HA, O’Keefe, RJ, Bukata SV, Schwarz, EM. Endogeneous tissue engineering: PTH therapy for skeletal repair. Cell and Tissue Research, May 31 2011

228. Sampson ER, Martin BA, Morris AE, Xie C, Schwarz EM, O’Keefe RJ, Rosier, RN. The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/marix production in a xenograft model. The Journal of Bone and Mineral Research, June 26 2011

229. Katzel EB, Koltz, PF, Tierney R, Williams JP, Awad HA, O’Keefe RJ, Langstein HN. The impact of Smad3 loss of function on TGF-B Signaling and Radiation-Induced Capsular Contracture. Plastic and Reconstructive Surgery. 27 (6); 2263-9, June 2011

230. Dhakal S, Chen J, McCance S, Rosier R, O'Keefe R, Constine LS. "Bone density changes after radiation for extremity sarcomas: exploring the etiology of pathologic fractures." International Journal of Radiation Oncology, Biology, Physics; 80(4): 1158-63, July 2011

231. Hu CT, Offley SC, Yaseen Z, O'keefe RJ, Humphrey CA. "Murine model of oligotrophic tibial nonunion." Journal of Orthopaedic Trauma. 25(8): 500-5, August 2011

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232. Yacizi C, Takahata M, Reynolds DG, Xie C, Samulski RJ, Samulski J, Beecham EJ, Gertzman AA, Spilker M, Zhang X, O’Keefe RJ, Awad HA, Schwarz EM. Self-complementary AAV2.5-BMP2-coated Femoral Allografts Mediated Superior Bone Healing Versus Live Autografts in Mice With Equivalent Biomechanics to Unfractured Femur. Molecular Therapy 19 (8): 1416-25. August 2011

233. Bukata SV, Kates SL, O'Keefe RJ. "Short-term and long-term orthopaedic issues in patients with fragility fractures." Clinical Orthopaedics and Related Research. 469(8): 2225-36. August 2011

234. Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ. "Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis." Science Translational Medicine. 2011; 101(3). September 2011

235. Takahata M, Schwarz EM, Chen T, O'Keefe RJ, Awad HA. "Delayed short course treatment with teriparatide (PTH(1-34) ) improves femoral allograft healing by enhancing intramembranous bone formation at the graft-host junction." Journal of Bone and Mineral Research 27 (1) 26-37. January 2012

236. Shu B, Zhang M, Xie R, Wang M, Jin H, Hou W, Tang D, Harris SE, Mishina Y, O'Keefe RJ, Hilton MJ, Wang Y, Chen D. "BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development." Journal of Cell Science; 124: 3428-40. October 2011

237. O'Keefe RJ, Mao J. "Bone tissue engineering and regeneration: from discovery to the clinic--an overview." Tissue Engineering Part B 17(6): 389-92. December 2011

238. Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. "Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression." Journal of Orthopaedic Research. 30(2): 325-33. February 2012

239. Kohn A, Dong Y, Mirando AJ, Jesse AM, Honjo T, Zuscik MJ, O'Keefe RJ, Hilton MJ. "Cartilage-specific RBPj?-dependent and -independent Notch signals regulate cartilage and bone development." Development. 139(6): 1198-212. March 2012

240. Kung MH, Yukata K, O'Keefe RJ, Zuscik MJ. "Aryl hydrocarbon receptor-mediated impairment of chondrogenesis and fracture healing by cigarette smoke and benzo(a)pyrene." Journal of Cellular Physiology. 227(3): 1062-70. March 2012

241. Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe RJ, Eliseev RA. "Targeting radioresistant osteosarcoma cells with parthenolide." Journal of Cellular Biochemistry. 113(4): 1282-91. April 2012

242. Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton MJ, Zuscik MJ. "Ski inhibits TGF-B/phospho-Smad3 signaling and accelerates

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hypertrophic differentiation in chondrocytes." Journal of Cellular Biochemistry. 113(6): 2156-66. June 2012

243. Loiselle AE, Frisch BJ, Wolenski M, Jacobson JA, Calvi LM, Schwarz EM, Awad HA, O'Keefe RJ. "Bone marrow-derived matrix metalloproteinase-9 is associated with fibrous adhesion formation after murine flexor tendon injury". PLoS One. 2012; 7(7). July 2012

244. Dao DY, Jonason JH, Zhang Y, Hsu W, Chen D, Hilton MJ, O'Keefe RJ. "Cartilage-specific ß-CATENIN signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development." Journal of Bone and Mineral Research 27:1680-1694, August 2012

245. Wang M, Tang D, Shu B, Wang B, Jin H, Hao S, Dresser KA, Shen J, Im HJ, Sampson ER, Rubery PT, Zuscik MJ, Schwarz EM, O'Keefe RJ, Wang Y, Chen D. "Conditional activation of B-catenin signaling leads to severe defects in intervertebral disc tissue." Arthritis and Rheumatism. August 2012

246. Farhat YM, Al-Maliki AA, Chen T, Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. "Gene expression analysis of the pleiotropic effects of TGF-?1 in an in vitro model of flexor tendon healing." PLoS One. December 2012

247. Ma Y, Ren Y, Han EQ, Li H, Chen D, Jacobs JJ, Gitelis S, O'Keefe RJ, Konttinen YT, Yin G, Li TF. “Inhibition of the Wnt-β-catenin and Notch signaling pathways sensitizes osteosarcoma cells to chemotherapy.” Biochem Biophys Res Communication. February 2013

248. Dhillon RS, Xie C, Tyler W, Calvi LM, Awad HA, Zuscik MJ, O'Keefe RJ, Schwarz EM. "PTH-enhanced structural allograft healing is associated with decreased angiopoietin-2-mediated arteriogenesis, mast cell accumulation, and fibrosis." Journal of Bone and Mineral Research. 28(3): 586-97 March 2013

249. Juneja SC, Schwarz EM, O'Keefe RJ, Awad HA. "Cellular and molecular factors in flexor tendon repair and adhesions: a histological and gene expression analysis." Connective Tissue Research. 54(3): 218-26. April 2013

250. Shah K, Majeed Z, Jonason J, O'Keefe RJ. "The role of muscle in bone repair: the cells, signals, and tissue responses to injury." Current Osteoporosis Reports. 11(2): 130-5. June 2013

251. Bonewald LF, Kiel DP, Clemens TL, Esser K, Orwoll ES, O'Keefe RJ, Fielding RA. "Forum on bone and skeletal muscle interactions: summary of the proceedings of an ASBMR workshop." Journal of Bone and Mineral Research. 28(9): 1857-65. September 2013

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252. Mirando AJ, Liu Z, Moore T, Lang A, Kohn A, Osinski AM, O'Keefe RJ, Mooney RA, Zuscik MJ, Hilton MJ. "RBP-J?-Dependent Notch Signaling Is Required for Murine Articular Cartilage and Joint Maintenance." Arthritis Rheumatology. 65(10): 2623-33. October 2013

253. Giang AH, Raymond T, Brookes P, de Mesy Bentley K, Schwarz E, O'Keefe R, Eliseev R. "Mitochondrial dysfunction and permeability transition in osteosarcoma cells showing the Warburg effect." The Journal of Biological Chemistry. 288(46): 33303-11. November 2013

254. Gao L, Sheu TJ, Dong Y, Hoak DM, Zuscik MJ, Schwarz EM, Hilton MJ, O'Keefe RJ, Jonason JH. "TAK1 regulates SOX9 expression in chondrocytes and is essential for postnatal development of the growth plate and articular cartilages." Journal of Cell Science. 126: 5704-13. December 2013

255. Shen J, Li J, Wang B, Jin H, Wang M, Zhang Y, Yang Y, Im HJ, O'Keefe R, Chen D. "Deletion of the transforming growth factor ? receptor type II gene in articular chondrocytes leads to a progressive osteoarthritis-like phenotype in mice." Arthritis and Rheumatism. 65(12): 3107-19. December 2013

256. Shane E, Burr D, Abrahamsen B, Adler RA, Brown TD, Cheung AM, Cosman F, Curtis JR, Dell R, Dempster DW, Ebeling PR, Einhorn TA, Genant HK, Geusens P, Klaushofer K, Lane JM, McKiernan F, McKinney R, Ng A, Nieves J, O'Keefe RJ, Papapoulos S, Howe TS, van der Meulen MC, Weinstein RS, Whyte MP. "Atypical subtrochanteric and diaphyseal femoral fractures: Second report of a task force of the American Society for Bone and Mineral Research." Journal of Bone and Mineral Research 29 (1) 1-23. January 2014

257. Hasslund S, O'Keefe RJ, Awad HA. “A mouse model of flexor tendon repair” Methods of Molecular Biology. 1130:73-88. 2014

258. Jonason JH, O'Keefe RJ. “Isolation and culture of neonatal mouse calvarial osteoblasts” Methods Molecular Biology. 1130:295-305. 2014

259. Li TF, Yukata K, Yin G, Sheu T, Maruyama T, Jonason JH, Hsu W, Zhang X, Xiao G, Konttinen YT, Chen D, O’Keefe RJ. “BMP-2 induces ATF4 phosphorylation in chondrocytes through a COX-2/PGE2 dependent signaling pathway”. Osteoarthritis Cartilage 22(3): 481-9. March 2014

260. Yukata K, Xie C, Li TF, Takahata M, Hoak D, Kondabolu S, Zhang X, Awad HA, Schwarz EM, Beck CA, Jonason JH, O'Keefe RJ. “Aging periosteal progenitor cells have reduced regenerative responsiveness to bone injury and to the anabolic actions of PTH 1-34 treatment”. Bone. 62:79-89. May 2014

261. Tyler W, Bukata S, O'Keefe RJ. “Atypical femur fractures”. Clinics in Geriatric Medicine. 30(2):349-59. May 2014

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262. Brown ML, Yukata K, Farnsworth CW, Chen DG, Awad H, Hilton MJ, O'Keefe RJ, Xing L, Mooney RA, Zuscik MJ. “Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus”. PLoS One.;9(6). June 2014

263. Farhat YM, Al-Maliki AA, Easa A, O'Keefe RJ, Schwarz EM, Awad HA. “TGF-beta1 Suppresses Plasmin and MMP Activity in Flexor Tendon Cells via PAI-1: Implications for Scarless Flexor Tendon Repair”. Journal of Cellular Physiology. June 2014

264. Huang C, Xue M, Chen H, Jiao J, Herschman HR, O'Keefe RJ, Zhang X. “The spatiotemporal role of COX-2 in osteogenic and chondrogenic differentiation of periosteum-derived mesenchymal progenitors in fracture repair”. PLoS One. 2;9(7). July 2014

265. Mann T, Baumhauer JF, O'Keefe RJ, Harrast J, Hurwitz SR, Voloshin I. “High Incidence of Hemiarthroplasty for Shoulder Osteoarthritis Among Recently Graduated Orthopaedic Surgeons”. Clinical Orthopaedics and Related Research 472(11):3510. November 2014

266. Hadjiargyrou M, O’Keefe RJ. “The Convergence of Fracture Repair and Stem Cells: Interplay of Genes, Aging, Environmental Factors and Disease”. Journal of Bone and Mineral Research 29(11):2307. November 2014

267. DiGiovanni BE, Southgate RD, Mooney CJ, Chu JY, Lambert DR, O’Keefe RJ. “Factors Impacting Musculoskeletal Knowledge and Clinical Confidence in Graduating Medical Students”. Journal of Bone and Joint Surgery 96A:21:e185. November 2014

268. Jonason JH, Hoak D, O’Keefe RJ. “Primary Murine Growth Plate and Articular Chondrocyte Isolation and Cell Culture”. Methods in Molecular Biology 1226:11. January 2015

269. Dong Y, Long T, Wang C, Mirando AJ, Chen J, O’Keefe RJ, Hilton MJ. “NOTCH-Mediated Maintenance and Expansion of Human Bone Marrow Stromal/Stem Cells: A Technology Designed for Orthopedic Regenerative Medicine”. Stem Cells Translational Medicine (in press). November 2014.

270. Lee DJ, Southgate RD, Farhat YM, Loiselle AE, Hammert WC, Awad HA, O’Keefe RJ. “Parathyroid hormone 1-34 enhances extracellular matrix deposition and organization during flexor tendon repair”. Journal of Orthopaedic Research 33:17. January 2015

271. Buckwalter JA, Tolo VT, O’Keefe RJ. “How Do You Know It Is True? Integrity in Research and Publications”. Journal of Bone and Joint Surgery (in press).

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272. Zhang M, Feigenson, M, Sheu, T-J, Awad, HA, Schwarz EM, Jonason JH, Loisell AE, O’Keefe RJ. “Loss of the PGE2 Receptor EP1 Enhances Bone Acquisition, Which Protects Against Age and Ovariectomy-induced Impairments in Bone Strength”. Bone 72:92-100. January 2015.

On-Line Publications

1. Grimsrud, C.D., Baumhauer, J.F., Teot, L., and O’Keefe, R.J.: Lytic lesion of the talus. AAOS Orthopaedic Short Stories, posted October 1999

Abstracts Provided Upon Request

Book Chapters

1. Rosier, R.N., Gelb, D.E., Landeserg, R.L., Crabb, I.D., O'Keefe, R.J., and Puzas, J.E.: “Transforming growth factor beta synthesis in endochondral ossification, in calcium regulation and bone metabolism.” Basic and Clinical Aspects, editors: Cohn, D.V., Glorieux, F.H., and Martin, T.J. Vol. 10:291-297, Elsevier, Amsterdam, 1990

2. Puzas, J.E., O'Keefe, R.J., and Hicks, D.G.: “Mechanisms of bone resorption in osteomyelitis.” Methods in Enzymology, 1994

3. Temple, H.T., O'Keefe, R.J., and Scully, S.P.: “Benign and malignant tumors of the foot.” Orthopedic Knowledge Update of the Foot 1, American Academy of Orthopedic Surgeons, Rosemont, IL, 1994

4. Rosier, R.N., and O’Keefe, R.J.: “Autocrine regulation of articular cartilage.” Instructional Course Lectures, Vol. 47, editor: W.D. Cannon, Jr., American Academy of Orthopaedic Surgeons, Rosemont, IL.1998

5. Rosier, R.N, O’Keefe, R.J., Reynolds, P.R., Hicks, D.G., and Puzas, J.E.: “Expression and function of TGF-ß and PTHrP in the growth plate.” Skeletal Growth and Development, editors: Buckwalter, J.A., Ehrlich, M.G., Sandell, L.J., and Trippel, S.B.: pp. 285-299, American Academy of Orthopaedic Surgeons, Rosemont, IL, 1998

6. O’Keefe, R.J., Grimsrud, C., D’Souza, M., Hicks, D.G., Puzas, J.E., Reynolds, P.R., and Rosier, R.N.: “Bone morphogenetic proteins commit growth plate chondrocytes to maturation.” Skeletal Growth and Development, editors: Buckwalter, J.A., Ehrlich, M.G., Sandell, L.J., and Trippel, S.B.: pp. 319-332, American Academy of Orthopaedic Surgeons, Rosemont, IL, 1998

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7. Reynolds, P.R., Romano, P.R., Hongbo, C., Wang, J., Reynolds, S.D., Johnston, C.J., Leboy, P.S., Tiller, G.E., Dasouki, M.J., O’Keefe, R.J., Puzas, J.E., and Rosier, R.N.: “Identification and characterization of a novel phosphatase with a role in the growth plate chondrocyte maturation.” Skeletal Growth and Development, editors: Buckwalter, J.A., Ehrlich, M.G., Sandell, L.J., and Trippel, S.B.: pp. 359-369, American Academy of Orthopaedic Surgeons, Rosemont, IL, 1998

8. Rosier, R.N. and O’Keefe, R.J.: “Molecular mechanisms of metastasis.” Management of Metastatic Disease to the Musculoskeletal System, editors: Heiner, J.P, Kinsella, T., and Zdeblick, T.A.: Quality Medical Publishing, Inc. St. Louis, MO. (In press), 1998

9. O'Keefe, R.J. and Terek, R.M.: “Musculoskeletal oncology.” Orthopedic Knowledge Update 6, editor: Beaty, J.H.: American Academy of Orthopedic Surgeons, Rosemont, IL, 1998

10. Rosier, R.N., O’Keefe, R.J., and Reynolds, P.R.: “Molecular and cellular biology in orthopaedics.” Orthopaedic Basic Science: Biology and Biomechanics of the Musculoskeletal System, 2nd edition, editors: Buckwalter, J.A., Einhorn, T.A., and Simon, S.R.: pp. 19-76. American Academy of Orthopaedic Surgeons, Rosemont, IL, 2000

11. O'Keefe, R.J., Totterman, S., Schwarz, E.M., Looney, J.M., Seo, G.S., Tamez-Pena, J., Boyd, A. Bukata, S., Monu, J. and Parker, K.: “Assessment of the performance of engineered tissues in humans requires the development of highly sensitive and quantitative noninvasive outcome measures.” Function Tissue Engineering, editors: Guilak, F., Butler, D.L., Goldstein, S.A., and Mooney, D.J.: Springer-Verlag New York, Inc., 2003

12. Ionescu A.M., Drissi, M.H., and O'Keefe, R.J.: “Regulation of chondrocyte differentiation.” The Skeleton, editors: Massaro, M.J. and Rogers, J.M.: pp. 43-53. Humana Press, Totowa, NJ, 2004

13. Puzas, J.E., Campbell, J., O’Keefe, R.J., and Rosier, R.N.: “Lead toxicity in the skeleton and Its role in osteoporosis.” Nutrition and Bone Health, editors: Holick, M.F. and Dawson-Hughes, B.: pp. 363-376. Humana Press, Totowa, NJ, 2004

14. Ballock, R.T. and O’Keefe, R.J.: “Growth and development of the skeleton.” Orthopaedic Basic Science, 3rd Edition, editors: Einhorn, T.A., Buckwater, JA., and O’Keefe, R.J., 2005

15. Bukata, S.V. and O’Keefe, R.J.: “Orthopaedic complications of osteoporosis.” Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 6th Edition, founding editor Favus, M.J.: pp. 313-318. American Society for Bone and Mineral Research, Washington, DC, 2006

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16. Awad, H.A., O’Keefe, R.J., Lee, C.H., Mao, J.J: “Bone Tissue Engineering: Clinical Challenges and Emergent Advances in Orthopaedic and Craniofacial Surgery.” Principles of Tissue Engineering. LANZA, Chapter 83. 2013

Book Reviews

1. O’Keefe, R.J.: “Osteoporosis in Men. The Effects of Gender on Skeletal Health.” Eric S. Orwoll, editor. San Diego: Academic Press; 1999. Review in J. Bone Joint Surg. 83A: 319, 2001

Oral Presentations

“The characterization of growth plate chondrocytes separated by countercurrent centrifugal elutriation.” AOA Traveling Fellows Conference, Rochester, NY, October 9, 1987

“The response of epiphyseal chondrocytes to transforming growth factor-beta is influenced by serum factors.” 34th Annual Meeting of the Orthopaedic Research Society, Atlanta GA, February 2, 1988

“Synergistic effects of IGF-I with TGF-ß and FGF are specific for DNA synthesis in growth plate chondrocytes.” 35th Annual Meeting of the Orthopaedic Research Society, Las Vegas, Nevada February 7, 1989

“The influence of prostaglandins on DNA and matrix synthesis by growth plate chondrocytes.” 35th Annual Meeting of the Orthopaedic Research Society, Las Vegas, NV, February 8, 1989

“Differential expression of transforming growth factor-beta receptors and biological effects in chondrocytes.” 36th meeting of the Orthopaedic Research Society, New Orleans, LA, February 6, 1990

“Analysis of type II and type X collagen synthesis in cultured chondrocytes by in-situ hybridization.” 37th meeting of the Orthopaedic Research Society, Washington, DC,February 17, 1992

“TGF-ß secretion is regulated by inflammatory cytokines in both growth plate and articular chondrocytes.” 41st Meeting of the Orthopaedic Research Society, Orlando, FL, February 13-16, 1995

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“The pathophysiology and treatment of metastatic bone disease.” Pathologic Bone Loss Symposium at the 44th Annual meeting of the Orthopaedic Research Society, New Orleans, LA, March 17, 1998

“Cells in pigmented villonodular synovitis secrete cytokines known to mediate osteoclastic bone resorption and cartilage degradation.” American Academy of Orthopaedic Surgeons Annual Meeting, New Orleans, LA, March 20, 1998

“Infection and bone healing.” American Academy of Orthopaedic Surgeons 65th annual meeting, New Orleans, LA, March 21, 1998

“Limb salvage in foot and ankle sarcoma.” Musculoskeletal Tumor Society, Washington, DC, May 8, 1998

“Molecular approaches to an understanding of periprosthetic osteolysis.” Interurban Orthopaedic Association Meeting, Baltimore, MD, October 2, 1998

“Bone morphogenetic protein signaling regulates chondrocyte maturation and Indian hedgehog expression.” 2nd Joint Meeting of The American Society for Bone and Mineral Research and The International Bone and Mineral Society, San Francisco, CA, December 2, 1998

“Coordinate interaction of tissues, cells, and growth factors during skeletal growth and development.” Skeletal Development and Regeneration Workshop at the 45th Annual Meeting of the Orthopaedic Research Society, Anaheim, CA, February 1, 1999

“Molecular changes and soft tissue sarcoma.” Musculoskeletal Tumor Society Specialty Day, 68th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Francisco, CA, March 3, 2001

“Intracellar signals regulate chondrocyte differentiation in the growth plate.” AAOS/NIH Workshop Biology in Orthopaedics, Scottsdale, AZ, September 8, 2001“Intracellular signaling and chondrocyte differentiation.” National Institute of Health (NIAMS), Bethesda, MD, December 6, 2001

“Signaling mechanisms utilized by TGF-β to regulate the rate of chondrocyte differentiation.” TGF-β Signaling Symposium at the 48th Annual meeting of the Orthopaedic Research Society, Dallas, TX, February 10, 2002

“The cellular and molecular basis of gene therapy.” Gene Therapy in Orthopaedic Surgery at the 69th Annual Meeting of the American Academy of Orthopaedic Surgeons, Dallas, TX, February 14, 2002

“US Bone and Joint Decade team report.” AAOS Board of Directors Meeting, AAOS Annual Meeting, San Francisco, CA, March 8, 2004

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“Update on US Bone and Joint Decade.” Orthopaedic Research Society Annual Business Meeting, Council of Musculoskeletal Specialty Societies, San Francisco, CA, March 10, 2004

“Effects of Cox-2 inhibitors on fracture healing.” AAOS Annual Meeting, AAOS Adult Reconstruction Hip and Knee Symposium: The Role of Pharmacological Agents in Fracture Healing and Implant Fixation, San Francisco, CA, March 10, 2004

“Overview of the AAOS Clinician Scientist Program and career path timeline.” Clinician Scientist Development Program, 117th Annual Meeting American Orthopaedic Association, Boston, MA, June 22, 2004

“NFk ß and retinoid receptors regulate pro-and anti-metastatic gene expression”. Molecular Biology and Pathology of Bone Working Group - Skeletal Metastasis: Tumor Interactions w/the Bone Microenvironment, 26th Annual Meeting ASBMR, Seattle, WA, October 4, 2004

“Smad3 deficient chondrocytes have accelerated differentiation and enhanced BMP signaling: concurrent oral 25, BMPs and other growth factors II”, 26th Annual Meeting ASBMR, Seattle, WA, October 5, 2004

“Bone and Joint Decade: Good moves for life.” National Association of Orthopaedic Nurses, ORS/AAOS Annual Meeting, Washington, DC, February 19-25, 2005

“TGF-ß and PTHrP regulate the stimulatory effects of BMPs, Runx2 and ß -Catenin on chondrocyte maturation.” Molecular Circuits Regulating Long Bone and Joint Development, ORS/AAOS Annual Meeting, Washington, DC, February 19-25, 2005

“Allograft bone revitalization through gene delivery.” Gene Therapy and Tissue Engineering in Orthopaedic Surgery, ORS/AAOS Annual Meeting, Washington, DC, February 19-25, 2005

“COX-2 in cartilage and bone.” New York Academy of Sciences Meeting, New York, NY, May 19, 2005

“The clinician scientist as an endangered species: A great time to start.” AAOS/OREF/ORS Clinician Scientist Development Program, Huntington, CA, June 20-22, 2005

“The Clinician Scientist Program and career path timeline.” AAOS/OREF/ORS Clinician Scientist Development Program, Huntington, CA, June 20-22, 2005

“Infrastructure support for the basic scientist.” AAOS/OREF/ORS Clinician Scientist Development Program, Huntington, CA, June 20-22, 2005

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“Grant writing for the basic scientist.” AAOS/OREF/ORS Clinician Scientist Development Program, Huntington, CA, June 20-22, 2005

“TGF-ß signaling in chondrocytes.” Parathyroid Hormone: A New Frontier in Bone Health, ASBMR 27th Annual Meeting, Nashville, TN, September 23-27, 2005

“The RANK RANKL OPB Axis.” ASBMR 27th Annual Meeting, Nashville, TN, September 23-27, 2005

“Revitalization of allograft bone by addition of cells and genes: Can we replace autograft?” Orthopaedic Basic Science Conference, Minneapolis, MN, November 19, 2005

“Allograft bone revitalization through gene delivery.” Gene Therapy and Tissue Engineering in Orthopaedic Surgery, ORS/AAOS Annual Meeting, Chicago, IL, March 18-24, 2006

“Bone and Joint Decade: Report.” AAOS Board of Directors Meeting, ORS/AAOS Annual Meeting, Chicago, IL, March 18-24, 2006

“The challenge of basic science research training in orthopaedics.” Educational Paradigms in Orthopaedic Research Workshop, ORS/AAOS Annual Meeting, Chicago, IL, March 18-24, 2006

“Overview of the AAOS clinician scientist program and career path.” AAOS/OREF/ORS Clinician Scientist Development Program, San Antonio, TX, June 19-20, 2006

“Morphometric Analysis of Osteoarthritis in Murine Models.” The Xth Congress of the International Society of Bone Morphometry, Philadelphia, PA, September 20, 2006

“Potentials for Pharmacological Treatment.” Visiting Professor, Alumni Association 88th Annual Meeting, Hospital for Special Surgery, New York, NY, November 9, 2006

“Fracture Healing - Current Concepts and Research Directions.” Introductory Lecture at Orthopaedic Research Society Session 37, Fracture Healing. Orthopaedic Research Society Meeting, San Diego, CA, February 13, 2007

“Gene Therapy & Tissue Engineering in Orthopaedic Surgery”. AAOS Instructural Course, San Diego, CA, February 14, 2007

“TGF-beta/Smad3 signaling modulate multiple signaling pathways during chondrocyte differentiation”. Gordon Research Conference (Cartilage Biology & Pathology),Ventura Beach Marriott, Ventura, CA. March 4-9, 2007

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“Transcription Regulation of Cartilage”. The New York Academy of Sciences, 2nd Conference on Skeletal Biology, New York Academy of Sciences, New York, NY. April 25-28, 2007

“Grant Writing 101”. AAOS Clinician Scientist Development Program, Asheville, NC, June 10-12 2007

“A Personal Perspective: Balancing it All”. AAOS Clinician Scientist Development Program, Asheville, NC, June 10-12 2007

“Wnt Signaling in Chondrocyte Differentiation.” AAOS/ORS/OREF Combined Meetings, San Francisco, CA, March 2, 2008

“Delayed Bone Repair in Aged Animals is Associated with Altered Cellular and Molecular Signals”. Workshop 5 - Orthopaedic Complications in Animal Models of Aging - Orthopaedic Research Society Annual Meeting, Las Vegas, NV, February 23, 2009

“Molecular targets and potential therapies to improve fracture healing in aging.” AIMM/ASBMR John Haddad Young Investigators Conference, Fracture healing lecture, Snowmass, CO, April 4, 2009 “Translational research using animal models of human disease.” AIMM/ASBMR John Haddad Young Investigators Conference, Meet the Professor lecture, Snowmass, CO, April 5, 2009

“Gene Therapy & Tissue Engineering in Orthopaedic Surgery”. AAOS Instructural Course, Las Vegas, CA, February 26, 2009

“Role of Non-Orthopaedic Providers in the Education of Orthopaedic Residents: Non Orthopaedic Providers: Can Teaching be Integrated into Clinical Service?” AOA Annual Meeting Hyatt Regency Coconut Point Resort, Bonita Springs, FL, June 11, 2009

“ICL 262 Biological Implants”, AAOS Instructural Course - New Orleans, LA, March 10, 2010

“What have been the most significant advances in musculoskeletal basic science in the last decade? What breakthroughs do you see being made in the next decade?” BJD World Network Conference, Lund, Sweden, September 10-11, 2010

“Cells and Molecular Signals Involved in Bone Repair: Insights Gained from Animal Models,” In Vivo Working Group, Bone Fracture Repair: From Bench to Bedside, ASBMR Annual Meeting, Toronto, Ontario, Canada, October 15, 2010

“Clinician Scientist/Scholar Timeline,” AAOS CSDP Webinar Module One- Translational Research, CS Timeline and Work/Life Balance, November 2, 2010

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“MAP Kinase Signaling and Chondrocyte Differentiation” 4th New York Skeletal Biology and Medicine Conference, Mt. Sinai School of Medicine, New York, NY, April 30, 2011

Implementing Results of CER in Academic Medical Centers: Panel Discussion: Joshua Jacobs, MD, James Wright, Regis O'Keefe, MD PhD and Michael Keith, MD AAOS/ORS Comparative Effectiveness Research Symposium - Hyatt Regency on Capitol Hill, Washington, DC, May 20, 2011

"Improving Orthopaedic Care Through Translational and Clinical Research: Opportunities and Challenges", OREF-ORS Research Symposium, Naval Academy, San Diego, CA, May 23, 2011

"Cellular and Molecular Targets to Enhance Fracture Healing and Bone Formation in Aging" OREF-ORS Research Symposium, Naval Academy, San Diego, CA, May 24, 2011

"The Science of Mentoring and Scientific Development: Roles, Responsibilities, and Rewards" OREF-ORS Research Symposium, Naval Academy, San Diego, CA, May 24, 2011

“Division of Program Coordination, Planning, and Strategic Initiatives (DPCPSI)” Council of Councils, NIAMS Advisory Council Meeting, Bethesda, Maryland, September 27, 2011

“Signals Regulating the Proliferation, Expansion, and Differentiation of Mesenchymal Stem Cells in Skeletal Tissue Repair” International Symposium of Mesenchymal Stem Cells, Chengdu, China, October 12, 2011

“Orthopaedic Departmental Leadership – Lessons Learned And What Can I Do To Lead Effectively In My Workplace” SOMOS Annual Meeting, San Diego, CA, December 13, 2011

“From The Deckplates To The Military Treatment Center: How To Conduct Successful Military/Civilian Research” SOMOS Annual Meeting, San Diego, CA, December 14, 2011

“Harassment and Headaches: Why Bother with Multicenter Trials”, 2012 AOA Annual Meeting, Washington, DC, June 28, 2012

“Orthopaedic Applications and Repair: Gaps in Our Knowledge of the Role of Muscle on Bone Repair” ASBMR Topical Meeting on Bone and Skeletal Muscle Interactions, Kansas City, MO, July 18, 2012

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“Pearls and Pitfalls: What I Have Learned from Wins and Losses” OTA/ORS Grant Writing Workshop, Minneapolis, MN, October 3, 2012

“Atypical Femoral Fractures” ASBMR Annual Meeting, Minneapolis, MN, October 13. 2012

“Morphometric and Molecular Assessment of Bone Fracture Repair” XIIth Congress of the International Society of Bone Morphometry, Minneapolis, MN, October 18, 2012

“Stem Cells and their Regulation in Bone Repair”, OREF/ORS Central Indiana Regional Resident Research Symposium, Indiana University, Indianapolis, IN, April 5, 2013

“How Do You Know It Is True? Integrity In Research And Publications”, Symposium, AOA Annual Meeting, Denver, CO, June 13, 2013

“Why Delegate: Developing an Effective Leadership Team”, AOA Annual Meeting, Denver, CO, June 14, 2013

“How Do You Know It Is True? Integrity in Research and Publications, AAOS Annual Meeting, New Orleans, LA, March 12, 2014

“Clinician Scientist (Scholar): Timeline Overview”, AAOS/OREF/ORS Clinician Scholar Career Development Program, Rosemont, IL, September 26, 2014

“Progenitor Cells and Tissue Injury and Repair Processes”, Society of Military Orthopaedic Surgeons Annual Meeting, Phoenix, AZ, December 18, 2104

Invited Lectures/Grand Rounds

“Reversal of digitoxic ventricular arrhythmia’s by the alpha adrenergic blocking agents prazosin and trimazosin.” Cardiology Research Conference, Massachusetts General Hospital, Boston MA, October 19, 1983

“The local and neutrally mediated effects of sufentanil on canine skeletal muscle vascular resistance.” Cardiology Research Conference, Massachusetts General Hospital, Boston, MA, May 29, 1985

“Effects of transforming growth factor-ß on growth plate and articular chondrocytes.” Endocrinology Research Conference, University of Rochester, Rochester, NY, March 31, 1987

“Countercurrent centrifugal elutriation: a preliminary report on the separation of growth chondrocytes.” University of Rochester Orthopaedic Alumni Conference, Rochester, NY, June 11, 1987

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“Growth factor effects in chondrocytes from different maturational stages separated by countercurrent centrifugal elutriation.” Endocrinology Research Conference, University of Rochester, Rochester, NY, April 5, 1988 “Correlation between TGF-ß receptor binding and biological effects in growth plate chondrocytes.” University of Rochester Orthopaedic Alumni Conference, Rochester NY, May 4, 1988

“The influence of prostaglandins on DNA and matrix synthesis by growth plate chondrocytes.” Orthopaedic Resident's Night, New York Academy of Medicine, New York, NY, May 8, 1989

“Synergistic effects of IGF-I with TGF-ß and FGF are specific for DNA synthesis in growth plate chondrocytes.” University of Rochester, Orthopaedic Alumni Conference, Rochester, NY, May 19, 1989

“A complex thumb M-P dislocation in a 4 year old: A case report and review of the literature.” University of Rochester, Biannual Hand Symposium, Rochester, NY, May 1990

“Structure and function of the growth plate.” University of Rochester Surgical Grand Rounds, Rochester, NY, November 23, 1991

“P-glycoprotein expression in benign and malignant cartilage tumors.” Meeting of the North American Traveling Fellows, Rochester, NY, October 15, 1993

“Update on evolution and treatment of soft tissue sarcomas with emphasis on synovial sarcoma.” Grand Rounds, University of Rochester, Rochester, NY, November 11, 1993

“Mechanism and role of P-glycoprotein in chemotherapeutic resistance in musculoskeletal neoplasms.” Brown University, Department of Orthopedics Grand Rounds, Providence, RI, December 15, 1993

“Biology of fracture repair.” Oral Surgery Grand Rounds, Genesee Hospital, Rochester, NY, November 29, 1994

“Biological mechanisms of prosthetic implant loosening.” University of Rochester, Department of Orthopaedics Grand Rounds, Rochester, NY, March 16, 1995

“Bone growth and development from conception to old age.” Keynote Speaker, National Association of Orthopaedic Nurses Annual Meeting, Rochester, NY, March 25, 1995

“Cell signaling and regulation of cytokine synthesis in wear debris stimulated monocytes.” Case Western Reserve University, Department of Orthopaedics, Grand Rounds, Cleveland, OH, January 26, 1996

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“Pharmacologic modification of the inflammatory response to wear debris particles.” Case Western Reserve University, Cleveland, OH, Department of Orthopaedics Grand Rounds, January 27, 1996

“Mechanism of bone loss in metastatic carcinomas and reconstruction of severe acetabular bone deficits in metastatic disease.” University of Rochester, Department of Orthopaedics Grand Rounds, Rochester, NY, May 11, 1996

“The role of in situ hybridization for examination of musculoskeletal tissues.” Symposium Presenter, Society of In Vitro Biology Annual Meeting, San Francisco, CA, June 24, 1996 “The cloning and expression of BMP-7 in chick growth plate chondrocytes.” Gordon Research Conference, Proctor Academy, Andover, MA, July 29, 1996

“The potential of pharmacologic agents for the inhibition of periprosthetic bone loss and loosening.” Visiting Lecturer, Novartis Pharmaceuticals, Summit, NJ, April 24, 1997

“Bone morphogenetic proteins commit growth plate chondrocytes to maturation.” Invited Participant/Presenter NIH/AAOS Workshop on “Skeletal Morphogenesis in Growth.” Howey-in- the-Hills, FL, May 3-6, 1997

“Bone loss in cancer and in association with joint prostheses.” Grand Rounds, Department of Orthopaedics, University of Rochester, Rochester, NY April 10, 1998

“Periprosthetic loosening: Molecular mechanisms and therapeutic intervention.” University of Bristol, U.K., April 19, 1999

“Molecular mechanisms of bone metastasis: A search for therapeutic intervention.” University of Manchester, U.K., April 21, 1999

“Bone morphogenetic proteins are modulators of chondrocyte maturation.” University of Nottingham, U.K., April 26, 1999

“BMP’s stimulate chondrocyte maturation.” Southampton University, U.K. May 5, 1999

“Reconstruction of severe periacetabular metastases restores ambulation and independence.” Perth, Australia, May 9, 1999

“Periprosthetic loosening: Molecular mechanisms and therapeutic intervention.” University of Adelaide, Australia, May 12, 1999

“Reconstruction of severe periacetabular metastases restores ambulation and independence.” Adelaide, Australia, May 13, 1999

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“Periprosthetic loosening: Molecular mechanisms and therapeutic intervention.” University of Melbourne, Australia, May 15, 1999

“Mechanisms of periprosthetic loosening.” Christchurch, NZ, May 17, 1999

“Mechanisms of bone metastasis.” Auckland, NZ, May 22, 1999

“Biological mechanisms of prosthetic loosening and potential therapeutic strategies.” Visiting Professor, Johns Hopkins Medical School, Department of Orthopaedics Baltimore, MD, September 30, 1999

“Periprosthetic osteolysis: Signaling pathways and pharmacologic approaches.” 93rd Annual Interurban Orthopaedics Society Meeting, In Symposium, Molecular Biological Approaches to the Prediction and Prevention of Arthroplasty Loosening, Rochester, NY, October 8, 1999

Visiting Professor for Resident Research Day, Hamot Medical Center, Erie, PA, May 2, 2000

Visiting Professor for Resident Research Day, University of Toronto, Toronto, Canada, May 29, 2000

“Functional evaluation of tissue engineered products requires innovative, sensitive, and quantitative methods.” Tissue Engineering Workshop, National Science Foundation, Tampa, FL, September 15-18, 2000

“Skeletal growth and development.” University of Rochester, Pathology and Molecular Medicine Seminar Series, April 18, 2001

“Regulation of chondrocyte differentiation in the growth plate.” University of Rochester, Department of Biochemistry Seminar Series, April 25, 2001

“Signaling events involved in PTHrP expression and effects in the growth plate.” First International Conference on the Growth Plate, San Antonio, Texas, June 17, 2001

Robert J. Kelly Visiting Professor, Mayo Clinic, Rochester Minnesota, November 29-December 1, 2001

“Molecular and therapeutic approaches to periprosthetic bone loss.” Mayo Clinic, Rochester, MN, November 30, 2001

“What motivates the clinician scientist.” Mayo Clinic, Rochester, MN, November 30, 2001

“Cyclooxygenases and bone repair.” Mayo Clinic, Rochester MN, December 1, 2001

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“RANKL and NFk β regulation of bone destruction.” Association of Bone and Joint Surgeons Workshop on Metastatic Bone Disease, Tampa, FL, November 8, 2002

“Cytokines, metalloproteases, and bone metastases.” Association of Bone and Joint Surgeons Workshop on Metastatic Bone Disease, Tampa, FL, November 8, 2002

“Mevalonate pathway and control of metastases: bisphosphonates, farnesyl transferase inhibitors and cytoskeletal regulation.” Association of Bone and Joint Surgeons Workshop on Metastatic Bone Disease, Tampa, FL, November 8, 2002

“Breakout session I report: Molecular biology and treatment of bone metastases.” Chairman, Association of Bone and Joint Surgeons Workshop on Metastatic Bone Disease, Tampa, FL, November 9, 2002

“The molecular events underlining prosthetic loosening.” University of Wisconsin, Madison, WI, December 18, 2002

“Transcriptional regulation of chondrocyte maturation.” Hospital for Special Surgery, New York, NY, January 13, 2004

“Mechanisms regulating chondrocyte differentiation.” Pathology, Oncology and Molecular Medicine Seminar Series, University of Rochester, Rochester, NY, March 29, 2004

“TGF-beta and BMP signaling in chondrocytes: mechanisms regulating chondrocyte maturation and osteoarthritis.” Molecular and Cell Pathology Seminar, The University of Alabama at Birmingham, Birmingham, AL, April 1, 2004

“The use of animal models to study human musculoskeletal diseases.” 42nd Murray S. Danforth Oration, Brown University, Providence, RI, May 12, 2004

“TGF-ß and BMP signaling in chondrocytes: mechanisms regulating chondrocyte maturation and osteoarthritis.” 42nd Murray S. Danforth Oration, Brown University, Providence, RI, May12, 2004

“The development and use of animal models to understand human musculoskeletal diseases.” Senior Resident’s Day, Dartmouth College, Dept. of Orthopaedic Surgery, Hanover, NH, June 18, 2004

“Understanding the cellular and molecular signals required for allograft revitalization and remodeling.” Gordon Research Conference - Signal Transduction By Engineered Extracell Matrices, Lewiston, ME, June 30, 2004

“TGF-beta and BMP signaling in chondrocytes: Mechanisms regulating chondrocyte maturation and osteoarthritis.” Endocrine Conference, Emory University, Atlanta, GA, October 11, 2004

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“Fracture repair.” Grand Rounds, Department of Orthopaedics, University of Rochester, Rochester, NY, February 3, 2005

“Methods to revascularize allograft bone in settings of segmental bone loss.” Regenerate 2005 Meeting, Georgia Tech, Atlanta, GA, June 2-3, 2005

“Defining the signals necessary for structural allograft revitalization and remodeling: Towards improving outcomes following bone resection.” Suzanne Berman Lectureship, University of Chicago, Chicago, IL, June 14-15, 2005

“Cell therapies for orthopaedic applications.” Chairman, Sun Valley Workshop, Sun Valley, ID, August 3, 2005

“Understanding the cellular and molecular signals required for allograft revitalization and remodeling.” 21st Annual Arkansas Orthopaedic Forum, Little Rock, AR, October 20-21, 2005

“Revitalization of allograft bone by addition of cells and genes: Can we replace autograft?” 35th Annual Ortho and Trauma Seminar, Minneapolis, MN, November 18, 2005

“Regeneration and remodeling of allograft bone.” Center for Craniofacial Regeneration Seminar, University of Michigan, Flint, MI, March 29, 2006

“Understanding and improving fracture healing in aging.” Columbia University Grand Round, New York, NY, April 12-13, 2006

“Models to investigate musculoskeletal diseases.” Celgene Cellular Therapeutics, Summit, NJ, April 20, 2006

“The role of stem cell signals in bone repair.” Bioengineering Seminar Series, University of NY at Stony Brook, Stony Brook, NY, May 3, 2006

“Understanding and improving fracture healing in aging.” Graduate Research Forum, University of California at Irvine, Irvine CA, May 31-June 2, 2006

“Understanding the cellular and molecular signals required for allograft revitalization and remodeling.” Graduate Research Forum, University of California at Irvine, Irvine CA, May 31-June 2, 2006

“Smads mediate chondrocyte hypertrophy and bone growth.” International Workshop on the Skeletal Growth Plate, Portland, OR, June 11-14, 2006

“Understanding and improving fracture healing in aging.” Graduation and Thesis Day Seminar Series, Cleveland Clinic Foundation, Cleveland, OH, June 15-16, 2006

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“Understanding the cellular and molecular signals required for allograft revitalization and remodeling.” Graduation and Thesis Day Seminar Series, Cleveland Clinic Foundation, Cleveland, OH, June 15-16, 2006

“Growth Factors and the Growth Plate.” 2006 Research Symposium on Developmental Biology in Orthopaedics, Toronto, Canada, October 26, 2006

“Economic Conditions of Running an Orthopaedic Department and Research Effort.” Visiting Professor, Alumni Association 88th Annual Meeting, Hospital for Special Surgery, New York, NY, November 10, 2006

“Understanding and Improving Fracture Healing In Aging.” Grand Rounds lecturer, Thomas McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, November 29, 2006

“Cells and Signals Necessary for Bone Regeneration and Repair.” Visiting Professor, Thomas McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh , PA, November 30, 2006

“Smad3 regulates multiple intracellular signaling pathways during chondrocyte maturation.” Grand Rounds speaker, Thomas Jefferson University, Philadelphia, PA, December 18, 2006

“Understanding and improving fracture healing in aging.” Visiting Professor, Thomas Jefferson University, Philadelphia, PA, December 18, 2006

“TGF-beta/Smad3 signaling modulate multiple signaling pathways during chondrocyte differentiation.” Gordon Research Conference - Cartilage Biology & Pathology, Ventura, CA, March 4-9, 2007

“Understanding and Improving Fracture Healing in Aging.” University of Iowa Sr. Residents' Day Program speaker, Cedar Rapids, IA, June 7-9, 2007

“Understanding the Cellular and Molecular signals required for Allograft Revitatilization and Remodeling.” University of Iowa Sr. Residents' Day Program speaker, Cedar Rapids, IA, June 7-9, 2007

“Understanding and improving bone repair in the aging population: new therapies on the horizon.” University of Washington Resident Research Days, Seattle, WA, June 27-30, 2007

“The Orthopaedic Clinician Scientist: What is the role and is it important.” University Washington Resident Research Days, Seattle, WA, June 27-30, 2007

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“Signaling Pathways Controlling Chondryocyte Maturation: Implications for the Development and Treatment of Osteoarthritis.” REF Marshall J. Schiff, M.D. Memorial Lectureship, American College Rheumatology, Boston, MA, November 8, 2007

“The challenges of allograft use for tumor surgery: strategies to improve allograft incorporation and function.” Residents’ speaker, University of Pennsylvania, Philadelphia, PA, January 9-10, 2008

“Fracture healing and aging: improved management through new therapies to improve healing.” Grand Rounds speaker, University of Pennsylvania, Philadelphia, PA, January 9-10, 2008

“The pathogenesis of osteoarthritis: molecular targets for potential therapeutics.” Laboratory presentation, University of Pennsylvania, Philadelphia, PA, January 9-10, 2008

“The challenges of allograft use for tumor surgery: strategies to improve allograft incorporation and function.” The John Hopkins University-School of Medicine, Department of Orthopaedic Surgery, 2nd Annual George B. Reid, Jr. Memorial Lecture, Baltimore, MD, March 13, 2008

“Fracture healing and aging: improved management through new therapies.” Visiting Professor Keynote Address, Stanford Research Day, Palo Alto, CA, March 29, 2008

“Fracture healing and aging: Improved management through therapies to improve healing.” Yale University, Center for Musculoskeletal Disorders, New Haven, CT, April 9, 2008

“Fracture healing in aging: Devising strategies to increase bone formation.” University of Connecticut, New Haven, CT, April 10, 2008

“The challenges of allograft use for tumor surgery: Strategies to improve allograft incorporation and function.” Grand Rounds, Yale School of Medicine, New Haven, CT, April 11, 2008

“Fracture healing and aging: Improved management through therapies to improve healing.” University of Minnesota, Minneapolis, MN, October 8, 2008.

“The Role of Stem Cells in Bone Repair and the Role of Altered Signals with Aging.” Bone Disease Program of Texas Seminar Series, MD Cancer Center, Houston, Texas, October 21, 2008

“Cells and Signals Involved in Bone Regeneration.” Hilton Head Workshop, Keynote Speaker, Regenerative Medicine: Advancing to Next Generation Therapies, Hilton Head, SC, March 6, 2009

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"Translational Research Using Animal Models of Human Disease.” Albert B. Ferguson Jr., MD Visiting Professor, Ferguson Visiting Professor, Resident Research Day, University of Pittsburgh, Pittsburgh, PA, May 19-20, 2009

“Translational Research Using Animal Models of Human Disease”- Bone & Joint Seminar and “Methods to Improve Fracture Healing in Aging.” Orthopaedic Grand Rounds, University of Wooster, University of Massachusetts, Memorial Medical Center, Wooster, MA, May 26, 2009

“Molecular Mechanisms of Reduced Bone Healing in Aging: Targets for Therapy.” Plenary Lecture: Bone Biology Forum, Saturday, August 22, 2009, Tokyo, Japan

“Cells and Signals in fracture repair: strategies to improve healing with aging." and “Signals and stem cell populations involved in tendon repair.” Hark Lecturer - Orthopaedics Grand Rounds, University of Virginia, Charlottesville, VA, October 14, 2009

“Signals and stem cell populations involved in tendon repair.” Grand Rounds Lecturer, Institute of Molecular Medicine and Genetics Medical College, Georgia, Augusta, GA, October 29, 2009

“Signals and stem cell populations involved in tendon repair.” Zunyi Medical College, Zunyi, Guizhou, China, November 16, 2009

“Molecular mechanisms of reduced bone healing in aging: Targets for therapy.” Eastern Forum Meeting, Shanghai, China, November 21, 2009

“The tissue, cellular, and molecular responses involved in scarring and adhesion formation during tendon repair" and "Molecular mechanisms of reduced bone healing in aging: Targets for therapy." China Orthopaedics Association, Shanghai, China, November 22, 2009

“Department of Orthopaedics and Rehabilitation Update: A Commitment to Excellence.” University of Rochester, Rochester, NY, Department of Orthopaedics Grand Rounds, January 21, 2010

“Cross Pollination Orthobiologics - What can we learn from our orthopaedic colleagues” AOFAS Specialty Day - New Orleans, LA, March 13, 2010

“Mechanisms whereby PTH stimulates fracture healing in young and aged mice.” - Annual Biologic Stain Commission Meeting, Renaissance at the Del Monte Lodge, Pittsford, NY, June 4, 2010

“Endochondral Bone Formation During Fracture Healing Is Coordinated by Periosteal Cell Signaling.” ASBMR Plenary Symposium III, Toronto, Ontario, Canada, October 18, 2010

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“Cellular and Molecular Targets to Enhance Fracture Healing and Bone Formation in Aging.” 5th International Conference on Osteoporosis and Bone Research, Shenzhen, China, October 30, 2010

"Improving Orthopaedic Care through Translational and Clinical Research: Opportunities and Challenges" CTSI Seminar Series, University of Rochester Medical Center, November 23, 2010

"Improving Orthopaedic Care Through Translational and Clinical Research: Opportunities and Challenges." University of Rochester, Rochester, NY, Department of Orthopaedics Grand Rounds, February 3, 2011

“Work Orthopaedic Tumor Surgeon” University of Rochester, Rochester, NY, Surgery Interest Group (“SIG”), February 7, 2011

"Improving Orthopaedic Care Through Translational and Clinical Research: Opportunities and Challenges", Second Friday Social Seminar Lecture Series, University of Rochester Medical Center, Rochester, New York, February 11, 2011

“The Science of Mentoring and Scientific Development: Roles, Responsibilities, and Rewards”, Vanderbilt University, Nashville Orthopaedic Society, Nashville, Tennessee, April 6, 2011

“Improving Orthopaedic Care Through Translational and Clinical Research: Opportunities and Challenges”, Vanderbilt University, Grand Rounds, Nashville, Tennessee, April 7, 2011

“Cellular and Molecular Targets to Enhance Fracture Healing and Bone Formation in Aging” Vanderbilt University, J. William Hillman Lecture, Nashville, Tennessee, April 8, 2011

“Improving Orthopaedic Care Through Translational and Clinical Research: Opportunities and Challenges” Arthur Stein Lecture, Washington University, St. Louis, MO, April 20, 2011

“Stem Cell Populations and Their Regulation in Bone Repair” 2011 Avioli Musculoskeletal Seminar, Washington University, St. Louis, MO, April 21, 2011

Grand Rounds Lecture: "The Science of Mentoring and Scientific Development: Roles, Responsibilities and Rewards”, UCLA, Los Angeles, CA, May 4, 2011

Grand Rounds Lecture: "Improving Orthopaedic Care Through Translational and Clinical Research: Opportunities and Challenges”, UCLA, Los Angeles, CA, May 4, 2011

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"How Do We Preserve and Stimulate INNOVATION in an Environment of Active Management, Standardization, Efficiency, and Cost Cutting?" Health Care Quality Innovation Summit, Cleveland Clinic, Cleveland, OH, May 11, 2011 – May 13, 2011

“Department of Orthopaedics and Musculoskeletal Care: Strategies for the Future”, University of Rochester, Rochester, NY, February 16, 2012

“Stem Cell Populations and Their Regulation in Bone Repair” Michigan State University, Secchia Center, MI, March 7, 2012

“Improving Orthopaedic Care Through Translational and Clinical Research: Opportunities and Challenges” Van Andel Research Institute, MI, March 7, 2012

“Chondrocyte Phenotype and Gene Expression and The Pathogenesis of Osteoarthritis”, University of North Carolina, Thurston Arthritis Research Center, Chapel Hill, NC, March 30, 2012

“The Role of Stem Cells and Their Regulation in Bone Repair” West Virginia University, Morgantown, WV, May 11, 2012

“Challenges of Health Reform: Need for Innovation in Musculoskeletal Care” West Virginia University, Morgantown, WV, May 11, 2012

“Use of Complementary Murine Models to Define the Cells, Molecular signals, and Therapeutic Targets to Improve Fracture Healing” AMGEN, Thousand Oaks, CA, May 31, 2012

“Improving Orthopaedic Care Through Translational and Clinical Research: Opportunities and Challenges” Annual Mallory-Coleman Research Day, Ohio State University, OH, June 8, 2012

“The Role of Stem Cells and Their Regulation in Bone Repair” University of Connecticut Health Center, New England Musculoskeletal Institute, Farmington, CT, June 22, 2012

“Healthcare Reform: Changes in the Care Delivery Model”, University of Rochester, Rochester, NY, February 7, 2013

“The Integration of TGF-beta and BMP Signaling in Cartilage Through MAP Kinase Signaling”, Orthopaedic Hospital Research Center, University California Los Angeles, CA, March 14, 2013

“Improving Orthopaedic Care Through Translational and Clinical Research: Opportunities and Challenges” University of North Carolina, Chapel Hill, NC, May 17, 2013

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“U.S. Healthcare and the World: How Do We Compare and Do We Need Change?” University of North Carolina, Chapel Hill, NC, May 17, 2013

“Stem Cell Populations and Signals That Regulate Bone Regeneration” Kobe Convention Center, Kobe, Japan, June 1, 2013

“Stem Cell Populations and Signals That Regulate Bone Regeneration” Rush University, Chicago, Illinois, June 20, 2013

“Bone Tumor – Clinical Progress” Southwest Hospital, Chongqing, China, August 12, 2013

“Bone Tumor – Clinical Progress” Zhejiang University, Hangzhou, China, August 15, 2013

“Musculoskeletal Medicine: Strategies for Future Success”, Yale University, New Haven, CT, March 19, 2014

“Stem Cell Populations and Signals that Regulate Bone Regeneration”, University of Alabama, Birmingham, AL, May 16, 2014

“The Clinician Scientist: Connecting Discovery with Advances in Clinical Care” Wake Forest School of Medicine, Winston-Salem, NC, November 20, 2014

Moderator of Scientific Sessions

“Scientific Session #2.” 93rd Annual Interurban Orthopaedics Society Meeting, Rochester, NY, October 9, 1999

“Basic Science 1.” 67th Annual Meeting of the American Academy of Orthopaedic Surgeons, Orlando, FL, March 17, 2000

“Miscellaneous Fundamentals.” 68th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Francisco, CA, March 2, 2001

“Developmental Biology Session.” 2001 AAOS/NIH Workshop Biology in Orthopaedics, Moderator, Scottsdale, AZ, September 7, 2001

“Basic Science II.” 69th Annual Meeting of the American Academy of Orthopaedic Surgeons, Dallas, TX, February 14, 2002

“Breakout Session I: Molecular Biology and Treatment of Bone Metastases.” Association of Bone and Joint Surgeons Workshop on Metastatic Bone Disease, Tampa, FL, November 9, 2002

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“The Orthopaedic Clinician Scientist.” American Orthopaedic Association 2003 Meeting, Symposium Moderator, Charleston, SC, June 9, 2003

“Evaluation of Biophysical Regulation of Skeletal Cells and Tissues.” NIH/AAOS Physical Regulation of Skeletal Repair Workshop, Session Moderator, Baltimore, MD, September 5-7, 2003

“Fracture Healing Session 15.” 50th Annual Meeting of the Orthopaedic Research Society, San Francisco, CA, March 7, 2004

“Influence of Sex Specificity and Gender on Musculoskeletal Health.” American Academy of Orthopaedic Surgeons, Hunt Valley, MD, April 22-24, 2004

“Symposium 1: Successful Clinician Scientist Business Models.” American Orthopaedic Association 117th Annual Meeting, Boston, MA, June 24, 2004

“Translation: Basic Science to Clinical Application.” Gordon Research Conference, Musculoskeletal Biology and Bioengineering, Andover, NH, July 28, 2004

“Panel reactor (American Academy of Orthopaedic Surgeons).” ACR Annual Meeting, San Antonio, TX, October 18, 2004

“Fracture healing.” ORS/AAOS Annual Meeting, Washington, DC, February 19-25, 2005

“Chondrocyte, Joint and Growth Plate Development land Pathology.” 2006 Research Symposium on Developmental Biology in Orthopaedics, Toronto, Canada, October 26, 2006

“Fracture Healing”, Moderator, Orthopaedic Research Society Annual Meeting, San Diego, CA, February 13, 2007

“Biological Questions in Implant Wear”, Moderator, AAOS/NIH Osteolysis and Implant Wear: Biological, Biomedical Engineering and Surgical Principles, Austin, TX, November 9-11, 2007

“Gene Therapy and Tissue Engineering in Orthopaedic Surgery”, Moderator with Steve Goldstein, PhD and Johnny Huard, MD, AAOS Annual Meeting, San Francisco, CA, March 6, 2008

“Running a Lab.” AAOS / ORS / OREF Clinician Scientist Development Program (CSDP) Quebec City, Canada, June 1-3, 2008

“Paper session: Tumor.” Moderator, AOA/COA Combined Annual Meeting, Quebec City, Canada, June 4-7, 2008

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“Genomic Screening Techniques for Disease Susceptibility and New Treatments.” Moderator, 2008 AAOS/ORS Molecular Biology and Therapeutics in Musculoskeletal Oncology Research Symposium Therapeutics in Musculoskeletal Oncology, Research Symposium, Hilton Salt Lake City Center, Salt Lake City, UT, September 25-27, 2008

“Gene Therapy and Tissue Engineering in Orthopaedic Surgery.” Moderator with Steve Goldstein, PhD and Johnny Huard, MD, AAOS Annual Meeting, Las Vegas, NV, February 23, 2009

“Bone Tissue Engineering and Regeneration: From Discovery to the Clinic” Co-Chair/Moderator with Dr. Jeremy Mao - 2010 TERMIS-NA Pre-Conference Workshop, Lake Buena Vista, Florida, December 4, 2010

“How to gain independence from your mentor or advisor and develop your own niche” Professional Advancement Series I, Developing and Managing your Collaborations and Colleagues, 2011 Orthopaedic Research Society Annual Meeting, Long Beach, CA, January 13, 2011

“A typical fractures: What are they? Does the epidemiologic evidence support defining them as a separate entity?” Workshop 10, Atypical Subtrochanteric Femoral Shaft Fractures: The What, the How, and Where Do We Go Now? 2011 Orthopaedic Research Society Annual Meeting, Women’s Leadership Forum, Long Beach, CA, January 15, 2011

"Building Your Local Orthopaedic Research Program" Funding a Program: Whatis the Role of Institutional, Departmental, and Extramural Support? AOA Symposium, AOA Annual Meeting, Boston, MA, June 24, 2011

“Session 2 MSCs in Bone Formation” International Symposium of Mesenchymal Stem Cells, Chengdu, China, October 11, 2011

“Basic Science Session II.” Moderator with LCDR Joseph R. Carney, MD, MC, USN., SOMOS Annual Meeting, San Diego, CA, December 13, 2011

“Tumor/Infection/Practice Management Scientific Session IV.” Moderator with MAJ Joseph F. Alderete MD, MC. SOMOS Annual Meeting, San Diego, CA, December 13, 2011

“Sixteenth Annual Resident Research Symposium.” West Virginia University, Morgantown, WV, May 11, 2012

“40th Annual Mallory-Coleman Research Day” Ohio State University, Columbus, OH, June 8, 2012

“Session 4, Defective Mechanotransduction and Repair”, ASBMR Topical Meeting on Bone and Skeletal Muscle Interactions, Kansas City, MO, July 18, 2012

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regis james o'keefe, m.d. - washington university in … · web viewregis j. o’keefe, md,...

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