regulating the cell cycle. warm up – the cell cycle the cell spends 80% of the time in...
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Regulating The Cell Cycle
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Warm Up – The Cell Cycle
•The cell spends 80% of the time in _______________ and 20% of the time in ________________
•What are the steps in mitosis?
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Key Concept
•How is the cell cycle regulated?
•How do cells know when to divide?
•How do you heal when you break a bone?
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Regulate the Cell Cycle
•Cyclin: A protein that regulates the cell cycle
•Tells the cell when to begin mitosis
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Growth Factors
•Growth factors stimulate the growth and division of cells
•When is this important?
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How Does a Cell Die?•1. Accident or injury
•2. Apoptosis: Programmed cell death
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What is Cancer?
•How have we been affected by cancer?
•How are cancer cells different from other cells?
•Why doesn’t everyone get cancer?
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Cancer•Cancer: Uncontrollable cell growth
•Cancer cells don’t respond to signals that regulate growth of cells
•Tumor: Mass of cells that divide uncontrollably
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What Causes Cancer?•Defects in genes that regulate cell growth and division.
•Sources?
•Defect in gene p53, which normally stops the cell cycle until all chromosomes are properly replicated.
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How Cancers Spread: Metastasis
•Cancerous cells lose control and continue to grow & divide, producing tumors which can metastasize (spread to other parts of the body)
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Think & Apply…•How are cancer cells different from normal cells?
•When researchers develop drugs, what characteristic of cancer cells do you think they target?
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Cancer: A Disease of the Cell Cycle • Driving Question:
From what we explore about cell growth and the cell cycle, why doesn’t everyone get cancer?
• Essential skills:2.1 The student will analyze the steps of the cell life cycle, including replication, mitosis and meiosis and describe the significance of each.
• 2.2 The student will explain the process of tumor propagation and cancerous cell division.
• Overview:How does cancer arise? We will explore the effect of environmental and genetic factors on cancer and how cell cycle regulation can go wrong.
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List of possible cancers:
• Colon CancerBreast cancer Lung cancerStomach cancerSkin cancer (melanoma)Hodgekin’s Lymphoma (immune system) Liver cancerLeukemia (blood)Prostate cancer Pancreas CancerColorectal Cancer (3rd most common)Brain cancerKidney Cancer