regulation of feed intake
DESCRIPTION
Regulation of Feed Intake. ANS/NUTRS 520 February 28,2012. Neural feedback. Ventromedial nucleus of hypothalamus (leptin) Stimulation decreases feed intake Lesions increase feed intake Lateral hypothalamus Stimulation increases feed intake Lesions decrease feed intake. CNS. - PowerPoint PPT PresentationTRANSCRIPT
ANS/NUTRS 520February 28,2012
Ventromedial nucleus of hypothalamus
(leptin) Stimulation decreases feed intake Lesions increase feed intake
Lateral hypothalamus Stimulation increases feed intake Lesions decrease feed intake
http://www.vivo.colostate.edu/hbooks/pathphys/digestion/pregastric/foodintake.html
◦ Satiety signals
◦ Energy balance
Absorbed compounds-or direct result of an absorbed compound
Fermentation products (VFA-mainly acetate, propionate)
Ammonia (urea)
Steroids, FSH, LH, PRL, ST-secondary effects
J Physiol Pharmacol. 2007 Dec;58 Suppl 6:23-52.
◦ 36 AA neural peptide◦ Secreted from hypothalamus◦ Increases feed intake◦ Stimulates fat production◦ Production may increase due to cold stress or
aggressive behavior (Nat Med. 13:7, 2007)
◦ 41 AA peptide produced in hypothalamus◦ Decreases feed intake
Signal of body energy (fat) and senses
energy balance Inhibits neuropeptide Y In fed state
◦ Correlates with body fat mass Fasted state (12-48 h)
◦ Rapid drop in leptin expression
Molecular Psychiatry (2005) 10, 132–146
J. Dairy Sci. 86:799-807
Released from enterocytes to stimulate release of enzymes and bile into duodenum
Stimulates release of GH from pituitary Signals energy status
Wertz-Lutz et al., 2006
Tahir et al., 2008
P metabolism in liver to glucose leads to
insulin release Increased insulin decreases DMI Dose VFA intravenously-no effect Infuse VFA into portal vein-decrease meal
size
Oba and Allen, J Nutr 133:1094
Bradford and Allen, 2007 JDS 90:2305
Bradford and Allen, 2007 JDS 90:2305