Relationship of Organic Chemistry to Biochemistry

Rondang R. Soegianto 2014

Chemistry is the Study of Matter

and its Changes

- What is matter?

- What are the changes?

BIOCHEMISTRY = LIFE SCIENCE

Chemistry of living system related to

Functions and Needs of the system

Matter changes thru chemical reactions

Atoms interact to form a bond =

Chemical bonding

- Ionic bonds

- Covalent bonds

Ionic Bonds

Atoms that loses e- pos ion (cation)

Atom that acquires e- neg ion (anion)

Ex. Ca + 2 Cl CaCl2

Covalent Bond

Sharing of a pair of electrons between atoms

Ex. H2 , CH4

BIOLOGICAL COMPOUNDS

Molecules of the body mainly:C, H, O, N, S, P

Joined by covalent bondsC is key element, forms covalent bondWith C, H, O, N, S

P usually linked to C by an oxygen atom.

FUNCTIONAL GROUPS

- Carbon-Oxygen groups- Carbon-Sulfur groups- Carbon-Nitrogen groups- Esters and Amides

Gambar 5.2a

Gambar 5.2b

Gambar 5.2c

KETONE BODIES are synthesized in the liver as acetoacetic acid andβ-hydroxybutiric acid.

At physiological pH they formtheir conjugate bases Acetoacetate and β-Hydroxybutirate

Gambar 4 Hal. 44

Groups That Carry a Charge

Acidic groups contain a proton that candissociate negative charge

Compouds containing N usually BASICand may acquire positive charge

Gambar Fig. 53

Gambar Fig. 54

REACTIVITY

Atoms with neg charge will be attracted

to atoms with pos charge and vice versa

Gambar Fig. 5.6

Gambar Fig. 5.7a (5)

Gambar Fig. 5.7b (6)

Gambar Fig. 5.8

Gambar Fig. 5.9

Gambar Fig. 5.10

Gambar Fig. 5.11

Gambar Fig. 5.12

Gambar Fig. 5.13

Gambar Page 50 No. 7