Clinical Resource: Ghosh, Mayo Clinic Internal Medicine Board Review 2008, 8th Edition, Lippincott, Williams & Wilkins. Part I Nephrology (pages 614-625) Glomerular Disease Clinical Presentation 1. Contrast microalbuminuria and overt proteinuria. Microalbuminuria - Urinary albumin excretion of 30-300 mg/1.73 m 2 per 24 hrs Over proteinuria - Urinary albumin > 300 mg/1.73 m 2 per 24 hrs Even minimal proteinuria is associated w/ ↑ cardiovascular risk; no such thing as normoalbuminuria 2. Define the nephrotic syndrome. Urinary protein > 3.5 g/1.73 m 2 per 24 hours, hypoalbuminemia (<3.0 g/dL), peripheral edema, hypercholesteremia, and lipiduria 3. Describe the laboratory and physical findings associated with the nephrotic syndrome. Edema can be prominent Urinalysis: waxy casts, free fat, oval fat bodies, lipiduria (“Maltese crosses”) Complications: hypogammaglobulinemia (inc risk of infections, e.g. cellulitis, spontaneous peritonitis) Vit D deficiency (d/t loss of Vit D-binding protein) iron deficiency anemia (d/t hypotransferrinemia) 4. Name the thrombotic complication of nephrotic syndrome. Thrombotic complications d/t increased levels of prothrombotic factors and decreased antithrombin III and antiplasmin renal vein thrombosis 5. Describe the urinary findings in nephritic syndrome. Urinary protein < 3.5 g/1.73 m 2 per 24 hours, hypoalbuminemia (<3.0 g/dL), peripheral edema, hypercholesteremia, and lipiduria
Clinical Resource: Ghosh, Mayo Clinic Internal Medicine Board
Review 2008, 8th Edition, Lippincott, Williams & Wilkins. Part
I Nephrology (pages 614-625)Glomerular Disease Clinical
Presentation 0. Contrast microalbuminuria and overt proteinuria. 1.
Microalbuminuria - Urinary albumin excretion of 30-300 mg/1.73 m2
per 24 hrs1. Over proteinuria - Urinary albumin > 300 mg/1.73 m2
per 24 hrs1. Even minimal proteinuria is associated w/
cardiovascular risk; no such thing as normoalbuminuria 0. Define
the nephrotic syndrome. 2. Urinary protein > 3.5 g/1.73 m2 per
24 hours, hypoalbuminemia (
