Renal Pathology II,Case 2

• A 63-year-old man presents with right flank pain that has been ongoing for the past several months

Identify the organDescribe the gross findingsIdentify the structures

Renal Cell CarcinomaThe surgical specimen consists of a whole kidney and attached ureter. There is a large, irregular carcinoma in the superior pole of the kidney.

A – CarcinomaB - Ureter

Identify the organDescribe the gross findingsIdentify the structures

Renal Cell CarcinomaThe surgical specimen consists of a bisected kidney that contains a renal cell carcinoma in the superior pole. The large, irregular neoplasm is yellow to golden and contains areas of hemorrhage (red). The yellow color and hemorrhage (increased vascularity) are characteristic pathologic findings in a renal cell carcinoma. Correlate the pathologic change with possible clinical presentations.

A – CarcinomaB – Normal Cortex

Describe the gross findingsIdentify the structures.Diagnosis?

Renal Cell CarcinomaThe autopsy specimen consists of a bisected left kidney, normal right kidney (arrow) and attached aorta. A renal cell carcinoma occupies the superior pole of the left kidney. The neoplasm is yellow and contains extensive hemorrhage

A – CarcinomaB – Normal cortexC – UreterD - Aorta

Describe the low and high power histologic findings of sections from the mass

Renal cell carcinoma, clear cell type

Tumor cells are rounded or polygonal shaped

with abundant clear or granular cytoplasm

(on special stains the cytoplasm stains for fat and glycogen).