I

I

III,,,

11 carbonicj., anhydrase II

CO2+H20~---=, C")

oUJ:S:~ Late Proximal Tubule

• Isosm. absorptionNa+

H+

•o Angiotensin II Stimulated

Aldosterone Stimulatedo ADH (vasopressin) Stimulatedo ANP Stimulatedo Sympathetic (Norepi.) Stimulated

~ Vasodilator

VasoconstrictorMajor effectMinor effect• insignificant. unless lots o' stirn.

Blood Flow

0-ro ""~III ::lC' '6(jl

0 0.C- o<1l 00. =

SQ):.;.o0:c0c

-0Q).0

K+0(jl.0ro~ Na++~ '"'0 K+--'''

~CI-

"g00N-0 Thickcro Ascending K++ LimbroZ • load-depend.'0 • H20 imp."g0 • DilutesL()N

Thin Ascending Limb• H20 impermeable

Nephron SchematicFind an error?

email dkm2112@columbia.edu

Afferent Arteriole

Late DistalTubule &Collecting Duct• a-Intercalated &

Principal Cells• H20 imp. wlo ADH

~-_. H20 permeablewithADH

a-Intercalated• Reabsorb K +

• H excretionAldost. stim'd

• H2P04 excret.• NH; excret.

K+~

New )I:HCO;absorbed

ATP

Principal Cell• Secrete K+• Add aquaporin2

ADH~ R

Gs

AC

J6\

Aldosterone increases # of:1. Na+channels2. Na+-K"':.ATPase pumps3. K+channels