ISRNM Special Review Panel for KDOQI Guidelines in Renal NutritionDate of release: January 5, 2016

Upon deliberations held in 2015 among Drs. Kerry Willis (National Kidney Foundation, NKF), Alison Steiber (Academy of Nutrition and Dietetics, AND), Kam Kalantar-Zadeh (International Society of Renal Nutrition and Metabolism, ISRNM) and other stakeholders, and in an effort to make the Kidney Disease Outcome Quality Initiatives (KDOQI) Evidence Based Practice Nutrition Guidelines in CKD a joint collaboration between NKF, AND and ISRNM, the executive committee of the ISRNM was charged to form a special review panel to work closely with the KDOQI in 2016 and beyond towards developing and reviewing updates on the guidelines in renal nutrition in collaboration with the NKF and AND. The ISRNM special review panel consists of 12 experts and reviewers in the field of renal nutrition, whose names, titles and background are listed below (in alphabetical order):

1. Debbie Benner, MS, RD, CSR, is a Registered Dietitian and Certified Specialist in Renal Nutrition.  She has been in the kidney care field for over 35 years and has over 40 publications in various areas of renal nutrition including as a coauthor on AND and NKF paper, “Revised 2014 Standards of Practice and Standards of Professional Performance for Registered Dietitian Nutritionists in Nephrology Nutrition.”. She serves as Vice President Clinical Support of a large dialysis provider overseeing the nutritional care responsibilities of 1,800 Renal Dietitians in North America. She has served as an executive board member on both NKF Council of Renal Nutrition (CRN) leadership group as well as AND’s Renal Dietetic Practice Group.Email: Debbie.Benner@davita.com

2. Mona Boaz, RD, PhD, Professor of Epidemiology and Chair of the Department of Nutrition Sciences, School of Health Sciences, Ariel University in Israel. aAdditionally, she is the Director, Epidemiology and Research Unit, E. Wolfson Medical Center, Holon, Israel, where, prior to earning her PhD at Sackler Faculty of Medicine, Tel Aviv University, she worked as a renal dietitian. It was there that Prof. Boaz developed her thesis topic, the role oxidative stress in cardiovascular etiology in hemodialysis patients. The findings of this study formed the basis of the Secondary Prevention using Antioxidants of Cardiovascular outcomes in End stage renal disease: SPACE (published in Lancet), in which pharmacological doses of vitamin E reduced composite cardiovascular endpoints. She has authored 200 scientific papers, including many in the area of nutritional epidemiology in the hemodialysis population. Co-principal investigator of the Status of Nutrition in Hemodialysis Patients Survey (SNIPS), a national nutrition survey of hundreds of hemodialysis patients throughout Israel. Prof. Boaz serves as the scientific advisor for the Renal Nutrition Specialty Practice License in Israel. monabo@ariel.ac.il

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3.Jing Chen, MD, PhD, is Professor of Medicine, Division of Nephrology, Huashan Hospital, Fudan Univ., Shanghai, China. Dr. Jing Chen received her MD and PhD degrees in Medicine from Medical College of Fudan Univ. (former Shanghai Medical Univ.) and has worked at Division of Nephrology, Huashan Hospital, Fudan Univ. since 1996. She conducted her postdoctoral research training in Division of Nephrology, Medical Center of Vanderbilt Univ., USA from 2003 to 2004. Dr. Chen has authored over 100 publications including many on mineral metabolism disorders and hemodialysis nutrition in Chinese population and has several grants from Chinese government related to the field. She is currently the director of Blood Purification Centre, vice director of Nephrology Division, director of Scientific Research Department of Huashan Hospital, Fudan Univ. and serve as vice Chairman of the Youth Commission of Chinese Society of Nephrology and many other academic groups works in China.Email: chenjing1998@fudan.edu.cn

4.Christiane Drechsler, MD, is a nephrologist at the University of Wuerzburg (under leadership of Prof. Christoph Wanner) in Wuerzburg, Germany. She earned her medical degree from the University of Wuerzburg in Germany and performed her residency there in internal medicine and nephrology. She has also been trained in clinical epidemiology and received the MSc and PhD degrees at the Universities of Rotterdam and Leiden in the Netherlands. As nephrologist and epidemiologist, she is doing clinical practice in nephrology as well as research activities. Her research work focuses on nutrition and metabolism in end-stage renal disease as well as on the clinical epidemiology of cardiac and diabetic complications in chronic kidney disease. She has authored more than 80 papers and is part of the guideline development team of European Renal Best Practice.Email: Drechsler_C@ukw.de

5.Fitsum Guebre-Egziabher, MD, PhD, is a Professor of Nephrology at University Grenoble Alpes, Grenoble, France, with expertise in Clinical Trials, Nephrology, and Nutritional Biochemistry. She is a member of the ISRNM council. She conducted her postdoctoral training in the Department of Internal medicine and Cellular & Molecular Physiology, endocrine section, Yale University School of Medicine, USA from 2009 to 2011. Dr Guebre-Egziabher research interests are centered on nutritional interventions, lipid metabolism, cellular mechanisms of insulin resistance, mineral metabolism disorder and impact of obesity in CKD.Email: fguebreegziabher@chu-grenoble.fr

6.Mary Kay Hensley, MS, RDN, CSR, has worked as a registered dietitian/nutritionist providing nutrition care to CKD patients for more than 40 years in the United States. She has served as Chair of the Council on Renal Nutrition (CRN), Chair of the Renal Practice Group (RPG), a division of the Academy of Nutrition and Dietetics, and as the Associate Council Member of the International Society of Renal Nutrition and Metabolism (ISRNM).  She has chaired many conferences to educate dietitians on various aspects of nutrition care for CKD patients. Highlights of her service include spearheading the development plan for the start-up of  the Journal of Renal Nutrition and contributing to the success of the Certified

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Specialist in Renal Nutrition credential granted by the Commission on Dietetic Registration (CDR) by serving on the Specialist Panel and other committees for many years. Email: marykayhensleyrd@aim.com

7.Kunitoshi Iseki, MD, graduated Medical School of the Kyushu University, Fukuoka, Japan, and received MD. He studied Nephrology with Drs. Shaul G Massry and Vito M Campese at University of Southern California, Los Angeles. Dr. Iseki has authored over 200 publications including clinical epidemiology of CKD and ESRD and currently is working with the CKD Prognosis Consortium and Asian Renal Collaboration group. He is currently the chief of Clinical Research Support Center at Tomishiro Central Hospital, Okinawa, Japan. He will be the president of the 18th Congress of Renal Nutrition and Metabolism. Email: chihokun_ohra@yahoo.co.jp

8.Kamyar Kalantar-Zadeh, MD, MPH, PhD, (Kam Kalantar) is Professor of Medicine, Pediatrics, and Public Health at Univ. California and Head of Nephrology. He studied medicine in Germany and received MPH and PhD degrees from Univ. California Berkeley, School of Public Health. He is trained in SUNY Brooklyn and UCSF and became board certified in Internal Medicine, Nephrology and Pediatrics. Dr. Kalantar has authored over 400 publications including many on renal nutrition; he has several NIH grants including the USRDS special study center “Transition of Care in CKD”. He is currently the President of ISRNM (2014-2016) and a member of the steering committee of the World Kidney Day (WKD) and a council member of the International Federation of Kidney Foundations (IFKF).Email: kkz@uci.edu

9.Csaba P. Kovesdy, MD, is The Fred Hatch Professor of Medicine in Nephrology and Director of the Clinical Outcomes and Clinical Trials Program at the University of Tennessee Health Science Center in Memphis, Tennessee and Chief of Nephrology at the Memphis VA Medical Center in Memphis, Tennessee.  Dr. Kovesdy earned his medical degree from the University of Pecs Medical School in Pecs, Hungary. He performed his residency in Internal Medicine at the Henry Ford Hospital in Detroit, MI, and completed a clinical fellowship in Nephrology at the Johns Hopkins Bayview Medical Center in Baltimore, MD. Dr. Kovesdy’s research interests are centered on epidemiology and outcomes in pre-dialysis chronic kidney disease, including studies in nutritional disorders. He has published his research in over 260 peer-reviewed articles.Email: ckovesdy@uthsc.edu

10.Anita Saxena, MD, PhD, Add. Professor, Department of Nephrology, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India. Dr Anita Saxena has done two PhD’s (Cambridge University, England and India). She is a licensed MD from WHO affiliated Indian Board of Alternative Medicine. Dr Anita has authored two books on renal nutrition and edited two books on clinical and nutritional approach to CKD and Medical Genetics. Prevention of malnutrition in CKD is her passion She has authored nutritional guidelines for Indian patients on hemodialysis. She has published on post-transplant hypertension, gene polymorphism in MIA syndrome, IDPN, prevention of

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intradialytic hypotension and has first report globally on use of bioimpedance in screening for CKD. She is currently Additional Professor in the department of Nephrology SGPGIMS, Lucknow and is Secretary Society Of Renal Nutrition and Metabolism and Editor Journal Of Renal Nutrition and metabolism. Email: anitimmy@yahoo.com

11.Pieter ter Wee, MD, PhD, is professor of Nephrology at the VU university medical center (VUmc) Amsterdam. He did his medical school at the Rijks Universiteit Groningen. In 1987 he switched from the Groningen university to the VU university in Amsterdam to finish his training in internal medicine with subsequent training in Nephrology. In 1992 and 1993 he did a postdoc with professor Murray Epstein at the VA hospital in Miami. From 1994 to 2014 he has chaired the department of Nephrology at the VUmc in Amsterdam. From 2007-2013 he was the president of the Dutch Federation of Nephrology and he has participated in several European Best Practice Guidelines. He has (co-)authored over 270 papers. His research topics are related to dialysis (peritoneal and hemodialysis) and nutritional aspects of chronic kidney disease and dialysis. Currently he is the chief medical officer of VUmc and president-elect of the International Society of Renal Nutrition & Metabolism.Email: pm.terwee@vumc.nl

12.Amanda Tortorici (Brown), MS, RD, CSCS. is a practicing registered dietitian at University of California, Irvine. Ms. Tortorici has conducted nutritional assessments on dialysis patients enrolled in the Malnutrition, Diet, and Racial Disparities in CKD study.  She is obtaining a PhD in the program of Public Health at UC Irvine with research focusing on phosphorous intake and dietary behaviors in dialysis patients.  Ms. Tortorici has published and lectured on nutrition and diet related to CKD.Email: amandab@uci.edu

ISRNM Liaison and KDOQI Member

Angela Yee Moon WANG, MD, PhD, FRCP, is an Associate Consultant and Honorary Associate Professor at the Queen Mary Hospital, Univ. Hong Kong, Hong Kong and a Visiting Professor of Nephrology at the Macau Institute of Applied Research in Medicine and Health. She is an Executive Committee Member of KDIGO, Secretary of ISRNM and a workgroup member of KDOQI Evidence Based Practice Nutrition Guidelines in CKD. She chairs the ISPD Adult Cardiovascular and Metabolic Guidelines I and II (2012 – 2015) and a subcommittee of ISPD PDOPPS. She was a Board member of KDIGO (2011-2015) and a Core workgroup member of KDIGO – CKD Mineral and Bone Disorder Clinical Practice Guidelines (2007-2009). She serves the editorial board of many nephrology journals including JASN CJASN (International editor 2010-2013), AJKD, AJN, Nephron Clin Pract (Associate Editor), J Nephrol, Nephrol (Subject Editor), J Ren Nutr, J Diabetes, Blood Purification, World J Hypertens, World J Nephrol, and J Geri Cardiol. She received John Maher Award of ISPD in 2006 and Travelling Lecturer Award of Asian and Pacific Federation of Clinical Biochemistry in 2012. She has authored over 140 publications and given over 100 invited lectures in international and regional conferences. Her research interests center on cardiovascular disease, mineral bone disease and nutrition in CKD and peritoneal dialysis.Email: aymwang@hku.hk

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Addendum by Dr Angela Wang on 1/17/2016

I missed last Nutrition guideline Chicago meeting in Oct 2015 but I joined part of it through teleconference. We are uncertain of the amount of evidence available in the different groups of renal pts and so, the WG decided to first search for evidence for all groups, including CKD 3-5, 5D and transplants and also nephrotic syndrome. we will see how much evidence there are first before deciding if we will drop those where no or only limited evidence can be found. So, low protein diet will certainly be an area of which evidence will be reviewed.

“KDOQI Clinical Practice Guideline for Nutrition in CKD”, co-sponsored by the AND and the NKF (the official title; the “Nutrition guideline” for short), and to be reviewed by ISRNM Special Review Panel by Spring 2017 prior to public review phase

To share with you all the nutrition guideline workgroup members and scope of work as below:

We divide the work into three groups, namely:

1. Macronutrients 2. Micronutrients3. Electrolytes and other nutrients

Members list is split into 3 groups to do the above 3 groups (8 persons from USA and 7 from France, UK, Switzerland, Hong Kong, Sweden, Australia, and Brazil):

1. Laura Byham-Gray, RD, PhD, CDN, USA (NJ). byhamgld@shrp.rutgers.edu 2. Denis Fouque, MD, PhD, France (Lyon). denis.fouque@chu-lyon.fr 3. Winnie Chan, MSc., PhD, UK (Birmingham) Winnie.Chan@uhb.nhs.uk 4. Jerrilynn Burrows, RD, PhD, CDN, USA (NY). Jerrilynn.Burrowes@liu.edu 5. Daniel Teta, MD, PhD, Switzerland Daniel.Teta@chuv.ch 6. Angela Wang, MD, PhD, Hong Kong aymwang@hku.hk 7. Jordi Goldstein-Fuchs, RD, PhD, USA (NV) jfuchs@nevadakidney.com 8. Joel D Kopple, MD, USA (CA) jkopple@labiomed.org 9. Sana Ghaddar, PhD, RD, USA (CA) sana.ghaddar@davita.com 10. Alp Ikizler, MD, USA (TN). alp.ikizler@vanderbilt.edu 11. Juan-Jesus Carrero-Roig, PharmaD, PhD, MBA, Sweden. Juan.Jesus.Carrero@ki.se 12. Katrina Campbell, RD, PhD, Australia. Katrina.Campbell@health.qld.gov.au 13. George A. Kaysen, MD, PhD, USA (CA). gakaysen@ucdavis.edu 14. Allon N Friedman, MD, USA (IN), allfried@iu.edu 15. Lilian Cuppari, RD, PhD, Brazil. lcuppari@uol.com.br

Emails: byhamgld@shrp.rutgers.edu ; denis.fouque@chu-lyon.fr ; Winnie.Chan@uhb.nhs.uk ; Jerrilynn.Burrowes@liu.edu ; Daniel.Teta@chuv.ch ; aymwang@hku.hk ; jfuchs@nevadakidney.com ; jkopple@labiomed.org ; sana.ghaddar@davita.com ; alp.ikizler@vanderbilt.edu ; Juan.Jesus.Carrero@ki.se ; Katrina.Campbell@health.qld.gov.au ; gakaysen@ucdavis.edu ; allfried@iu.edu ; lcuppari@uol.com.br