renu a. kowluru, ph - ouhscouvision.ouhsc.edu/visionschedule/cv/rkowluru.pdf · renu a. kowluru,...

Renu A. Kowluru, Ph.D Professor-Ophthalmology and Anatomy/Cell Biology

Wayne State University, Kresge Eye Institute 4717 St Antoine, Detroit, MI

E-Mail: [email protected] 313-993-6714 (voice) 313-577-8884 (fax)

EDUCATION Graduate MS (Biochemistry) Lucknow University, Lucknow; India; 1974 PhD Central Drug Research Institute, Lucknow, & Kanpur Biochemistry/Chemistry University, India; 1978 TRAINING Post-Doctoral Training 1978-1980 Brussels Free University, Brussels, Belgium, (Dr. Willy Malaisse, Director) 1981-1984 University of Wisconsin, Madison, WI, (Dr. Colin Jefcoate, Director) FACULTY APPOINTMENTS 1984-1991 Staff Member, Division of Life Sciences, Los Alamos National Laboratory, Los Alamos, NM 1991-1998 Associate Scientist (equivalent to Associate Professor-Research),

Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, WI

1999-2000 Adjunct Associate Professor, Kresge Eye Institute, Wayne State University, Detroit, MI 2000-2007 Associate Professor, Kresge Eye Institute, Wayne State University, Detroit, MI 2007- Professor, Ophthalmology, and Anatomy & Cell Biology; Wayne State University, Detroit, MI

Renu A. Kowluru, Ph.D.

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HONORS/AWARDS 1974 Secured first position in order of merit in Masters Program 1974-78 Junior and Senior Research Fellowships from the Council of Scientific and Industrial Research, New Delhi, India

1988 Certificate of Excellence from Los Alamos National Laboratory for Outstanding

Contribution to Research and Development 1999 Travel Award, American Diabetes Association 2000 Thomas Foundation Award to support investigation of metabolic abnormalities in the pathogenesis of diabetic retinopathy. 2003 Visiting Professor, National University of Singapore, Singapore. 2004 Dennise L. Gierhart Charitable Gift to support Diabetic Retinopathy Research 2001- ‘Regular Member’ of the Medical Science Research Review Committee- Complications, Juvenile Diabetes Research Foundation 2005 Doctoral Committee member- National University of Singapore School of Medicine 2006-2010 ‘Regular Member’ of the Biology and Diseases of the Posterior Eye Study Section (Visual Sciences C), National Institutes of Health 2006 Chair for the scientific session: ‘Diabetic Retinopathy: There is more than VEGF and PKC’, American Diabetes Association's 66th Scientific Sessions 2006 Moderator for the scientific session “Mechanisms of angiogenesis inhibition”, Annual Meeting of the Association for Research in Vision and Ophthalmology 2006 Mary Jane Kugel award from the Juvenile Diabetes Research Foundation 2007 Faculty Research Excellence Award, School of Medicine, Wayne State University 2008 Visiting Professor, University of Michigan, Ann Arbor, MI


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MAJOR PROFESSIONAL SOCIETIES American Diabetes Association Association for Research in Vision and Ophthalmology European Association for the Study of Diabetes European Association for Vision and Eye Research The Oxygen Society The Endocrine Society PROFESSIONAL CONSULTATION Abstract Reviewer, Society for Free Radical Biology & Medicine Abstract Reviewer, American Diabetes Association Scientific Advisory Committee; ZeaVision, St Louis, MO Research Grants Reviewer, Research Council of the University of Antwerp, Belgium Research Grants Reviewer, Wellcome Trust Foundation, UK Research Grant Reviewer, Healy Foundation, Australia Regular Member of the Medical Science Research Review Committee-Complications, Juvenile Diabetes Research Foundation Regular Member of the Biology and Diseases of the Posterior Eye Study Section (Visual Sciences C), National Institutes of Health JOURNAL/EDITORIAL ACTIVTY Editorial Board Memberships

Expert Opinion on Investigational Drugs, Ashlely Publications Ltd, London Investigative Ophthalmology & Visual Sciences International Journal of Biomedical Science


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Diabetes-Guest Associate Editor Manuscript Reviewer Acta Ophthalmologica

Archives of Ophthalmology American Journal of Physiology-Cell Physiology American Journal of Physiology-Endocrinology Biochemical Biophysical Acta British Journal of Ophthalmology British Journal of Pharmacology Current Eye Research Diabetes Diabetes and its Complications Diabetes Care Diabetes/Metabolism Research & Review Diabetologia Documenta Ophthalmologica European Journal of Clinical Nutrition Experimental Eye Research Expert Opinion on Investigational Drugs FEBS Letters Free Radical Biology and Medicine Investigative Ophthalmology and Visual Sciences Journal of Cellular Biochemistry


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Journal of Neurochemistry Lancet Metabolism Neuroscience Ocular Pharmacology and Therapeutics Pharmacological Research


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National and International Boards and Committees 2001 Ad-hoc Reviewer, National Eye Institute 2001 Study Section Member, Michigan Eye Bank and Transplantation Center 2001- Regular Member, Research Grant Review Committee-Complications, Juvenile Diabetes Research Foundation 2002- Ad-hoc Reviewer, Research Council of the University of Antwerp, Belgium 2002- Ad-hoc Reviewer, Wellcome Trust Foundation, United Kingdom 2003- Grant Reviewer, Healy Foundation, Australia 2003 Scientific Abstracts Evaluator, Society for Free Radical Biology & Medicine 2004 Study Section Member, Member, National Institute of Diabetes and Digestive & Kidney Disease 2004 Scientific Abstracts Evaluator, Society for Free Radical Biology & Medicine 2004-06 Study Section Member (Ad-hoc), Biology and Diseases of the Posterior Eye (VIS C), National Institutes of Health 2004 National Eye Institute SBIR GRANTS to ‘Develop New Therapies for Type I Diabetes and Its Complications’ 2004 Member, Special Emphasis Review Panel, ZRG1 SSS-U(03)M; Retinopathies–in vivo models and approaches to therapy 2005-08 Member, Diversity Issues Committee, Association for Research in Vision and Ophthalmology 2005 Study Section Member, National Institute of Diabetes and Digestive, and Kidney Diseases RFA: DK-05-001 ‘Preventing Mitochondrial Oxidative Stress in Diabetes and Obesity’ 2005 Study Section Member, National Institute of Diabetes and Digestive, and Kidney Diseases: ZDK1 ZRB-2 (C1) ‘Diabetic Complications in Animals’ 2005 Reviewer-Juvenile Diabetes Research Foundation, RFA: ‘Drug Screening Program for Diabetic Complications’ 2005 Scientific Abstracts Evaluator, Society for Free Radical Biology & Medicine


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2006-10 Regular member, Biology and Diseases of the Posterior Eye (VIS C), National Institutes of Health 2006 Scientific Abstracts Evaluator for the American Diabetes Association's 66th Scientific Sessions 2006 Scientific Abstracts Evaluator, Society for Free Radical Biology & Medicine 2006 Chair for the scientific session: ‘Diabetic Retinopathy: There is More than VEGF and PKC’, American Diabetes Association's 66th Scientific Sessions 2006 Moderator for the scientific session “Mechanisms of Angiogenesis Inhibition”, Annual Meeting of the Association for Research in Vision and Ophthalmology 2007 Scientific Abstracts Evaluator for the American Diabetes Association's 67th Scientific Sessions 2007 Scientific Abstracts Evaluator, Society for Free Radical Biology & Medicine 2007 Member- Special Emphasis Panel/Scientific Review Group ZDK1 GRB-N (M1) Biomarker Development for Diabetic Complications

Wayne State University Committees 2002- Member Core Vision Research Group, Wayne State University 2004-05 Member, Internal Review Committee, Kresge Eye Institute, Department of Ophthalmology 2005- Member, Faculty Search Committee, Department of Ophthalmology, and Anatomy & Cell Biology 2007- Member of the Clinical and Translational Science Award (CTSA) (Free Radicals sub- group) 2007-10 Research Development Committee of the Faculty Senate, Wayne State University


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TEACHING 1. Teaching and Mentoring at Wayne State University

Graduate and MD 2001-2003 Prashant Koppolu, MD; Resident 2003-2004 Saiyeda N Abbas, First year MD student 2004-2005 Lamia Atasi, Masters in Basic Medical Sciences 2006- Kamal Alwan, MD 2007 Steven Rayappa, Masters in Basic Medical Sciences

Undergraduate 2004-2006 Divyesh Sarman 2004 Srinuvasa Raghupatruni 2005 Meghna Shukla 2005- Vibhuti Kowluru 2006- Alissa Kerner 2006 Rahul Alawadhi 2007 Akhil Kanduru 2006 Yakov Shamailov 2007- Alexander Mark Tassopoulos Postdoctoral Fellows 2001-2002 Xiaohua Zhou, PhD 2005-2006 Anjaneyulu Murgundala, PhD 2006- Premanand C. Sundivakkam, PhD 2006- Pooi-See Chan, PhD


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2007- Jiang Ping Zhang, MD 2007 Vikram Srivastava, PhD 2007 Bindu Menon, PhD 2008- Sally Madsen-Bouters, PhD Research Assistants 2001-2001 Emilia Tambourov 2002-2005 Sarah Odenbach 2004-2005 Shivapriya Basak 2005- Mamta Kanwar 2006- Holly Birk 2006- Shuba Rajaram 2. Other Colleges/Universities 1. University of Wisconsin, Madison, WI 2. Oakland University, Oakland, MI 2004 Graduate course ‘Science of Vision’, BIO 491, lecture on ‘Diabetic

Retinopathy and Vascular Diseases’ 2005 Graduate course ‘Science of Vision’, BIO 491, lecture on ‘Diabetic




Retinopathy and Vascular Diseases’ 3. Courses Taught at Wayne State in Last Five Years Medical Students: 2005 MD-1 Histology laboratory


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2006 MD-1 Histology laboratory 2007 MD-1 Histology laboratory Resident/Fellows 2005-2006 Course Coordinator-Clinical and Basic Science Course in Ophthalmology-

Bench to Bedside series Lecture for the Clinical and Basic Science Course: ‘Metabolic Memory and

Diabetic Retinopathy’ 2006-2007 Course Coordinator-Clinical and Basic Science Course in Ophthalmology-

Bench to Bedside series 2007-2008 Course Coordinator-Clinical and Basic Science Course in Ophthalmology-

Bench to Bedside series 4. Thesis Directed Masters in Basic Medical Sciences thesis entitled ‘Altered nitric oxide

metabolism and its impact on endothelial tissue’ by Lamia Atasi; Wayne State University; 2004

External Advisor, PhD thesis “Dysfunctional signaling pathway for nitric

oxide production in endothelial cells chronically exposed to high glucose or fatty acids”. National University of Singapore, Singapore; 2005-2006


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PUBLICATIONS 1. Puri RB, Sahib MK, Kidwai JR, Anjaneyulu K: Postnatal development of acid phosphatase and cathepsin-B in rat pancreas. Indian J Exp Biology 14: 478-479, 1976 2. Puri RB, Kidwai JR, Sahib MK, Rao VKM: Effect of glucose and alloxan on acid phosphatase, cathepsin-B and insulin content in the islets of Langerhans of rat pancreas. Indian J Exp Biology 14:567-569, 1976 3. Puri RB, Kidwai JR, Anjaneyulu K, Rao VKM: Effect of glucose on incorporation of 14C leucine into pancreatic acid phosphatase and cathepsin B in rat. Indian J Exp Biology 33: 303-305, 1977 4. Puri RB: Chemical and biochemical studies on the regulation of insulin formation. Ph.D. Thesis, Kanpur University, India, 1977 5. Puri RB, Anjaneyulu K, Kidwai JR, Rao VKM: In Vitro conversion of proinsulin to insulin by cathepsin B and role of C-peptide. Acta Diabetol Latina 15: 243-250, 1978

6. Valverde I, Vandermeers A, Anjaneyulu R, Malaisse WJ: Calmodulin activation of adenylate cyclase in pancreatic islets. Science 206: 225-227, 1979 7. Malaisse WJ, Valverde I, Caprinelli A, Anjaneyulu R, Anjaneyulu K, Couturier E, Herchuelz A, Hutton JC, Sener A: Coupling of metabolic to cationic events in the process of insulin release. Possible role of native ionophores and endogenous calmodulin. In Diabetes, Waldausi WK ed. Excerpta Medica I.C.S. 75, pp 172, 1979

8. Malaisse WJ, Anjaneyulu K, Anjaneyulu R, Couturier E: Ionophore mediated Ca2+ transport: Role of Na+ Li+ or H+ gradient. Mol Cell Biochem 30:67-70, 1980

9. Anjaneyulu R, Anjaneyulu K, Couturier E, Malaisse WJ: Opposite effects of hypoglycemic and hyperglycemic sulfonamides upon ionophore mediated calcium transport. Biochem Pharmacol 29: 1879-1882, 1980

10. Anjaneyulu K, Anjaneyulu R, Malaisse WJ: The stimulus-secretion coupling of glucose-induced insulin release. Na+–Ca++ counter transport mediated by pancreatic islet native ionophores. J Inorg Biochem 13: 178-188, 1980

11. Anjaneyulu R, Anjaneyulu K, Carpinelli AR, Sener A, Malaisse WJ: The stimulus-secretion coupling of glucose induced insulin release: Enzymes of mannose metabolism in pancreatic islets. Arch Biochem Biophys 212: 54-62, 1981

12. Anjaneyulu K, Anjaneyulu R, Sener A, Malaisse WJ: Gamma-glutamyl transpeptidase activity in pancreatic islets. FEBS Letters 125: 57-59, 1981


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13. Anjaneyulu K, Anjaneyulu R, Sener A, Malaisse WJ: The stimulus-secretion coupling of glucose-induced insulin release: Thiol disulfide balance in pancreatic islets. Biochemie 64: 29-36, 1982

14. Kowluru RA, George R, Jefcoate CR: Polyphopshoinositide activation of cholesterol side chain cleavage with purified cytochrome P-450 scc. J Biol Chem 258: 8053, 1983

15. Narasimhulu N, Eddy CR, Dibartolomeis M, Kowluru RA, Jefcoate CR: Adrenal microsomal hydroxylation system: Purification and Substrate binding properties of cytochrome P-450 c-21. Biochemistry 24: 4287-4292, 1985 16. Kowluru A, Kowluru RA, Bitensky MW, Corwin EJ, Solomon S, Johnson JD: Suggested mechanism for the selective excretion of glucosylated albumin: The effects of diabetes mellitus and aging on this process and the origins of diabetic micro albuminuria. J Exptl Med 166: 1259-1279, 1987 17. Kowluru RA, Bitensky MW, Kowluru A, Dembo M, Keaton PA, Buican T: Reversible sodium pump defect and swelling in diabetic rat erythrocyte. Effects on filterability and implications for microangiopathy. Proc Natl Acad Sci (USA) 86: 3327-3331, 1989 18. Bitensky MW, Kowluru A, Kowluru RA: Non-enzymatic glycation and protein recognition. Prog Clin Biol Res 304: 185-203, 1989 19. Kowluru RA, Heidom D, Edmondson S, Kowluru A, Bitensky MW, Downer N, Whaley TW, Trewhella J: Glycation of calmodulin: Chemistry, and structural and functional consequences. Biochemistry 28: 2220-2228, 1989 20. Bitensky MW, Kowluru A, Kowluru RA: Non-enzymatic glycation and protein recognition. In The Maillard Reaction in Aging, Diabetes and Nutrition. Baynes JW and Monnier VM Eds. Pp 185-203 Alan R. Liss, New York, 1989

21. Bitensky MW, Dembo M, Kowluru A, Kowluru RA, Keaton PA, Buican TN: Increased survival of transfused red blood cells. In Research Highlights Annual Report of Physics Division. Los Alamos National Laboratory, Los Alamos, 1990

22. Dhariwal MS, Kowluru RA, Jefcoate CR: Cytochrome P-450 scc induces vesicle aggregation through secondary interactions at the adrenodoxin binding sites (in comparison with protein exchange). Biochemistry 30: 4940-4949, 1991

23. Kowluru RA, Kowluru A: Erythrocyte sodium-potassium ATPase activity and thiol metabolism in genetically hyperglycemic mice: Comparison with sreptozotocin diabetic rat. Metabolism 41: 160-164, 1992

24. Kowluru A, Kowluru RA: Phospholipid N-methylation in diabetic erythrocytes: Effects on membrane Na+ K+ ATPase activity. Cell Biochem Function 10: 95-101, 1992


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25. Kowluru A, Kowluru RA, Solomon S, Martinez L: Protein glycation: effects upon recognition by the proximal tubule. Life Sciences 50: 281-286, 1992

26. Kowluru A, Kowluru RA: Preferential excretion of glycated albumin in C57BL-KS-J mice. Effects of diabetes. Experientia 48: 486-488, 1992

27. Kowluru A, Kowluru RA, Yamazaki A: Functional alterations of G-proteins in diabetic retina: A possible explanation for the early visual abnormalities in diabetes. Diabetologia 35: 624-631, 1992

28. Kern TS, Kowluru RA, Engerman RL: Abnormalities of retinal metabolism in diabetes or galactosemia. I. ATPases and glutathione. Inves Ophthal Vis Sci 35: 2962-2967, 1994

29. Kowluru RA, Kern TS, Engerman RL: Abnormalities of retinal metabolism in diabetes and galactosemia. II. Comparison of gamma-glutamyl transpeptidase in retina and cerebral cortex and effects of antioxidant therapy. Current Eye Research 13: 891-896, 1994

30. Yamazaki T, Kowluru RA, McNamara BC, Jefcoate CR: P-450 scc-dependent cholesterol metabolism in rat adrenal mitochondria is inhibited by low concentrations of matrix calcium. Arch Bioch Bioph 318: 131-139, 1995

31. Kowluru RA, Yamazaki T, McNamara BC, Jefcoate CR: Metabolism of exogenous cholesterol by adrenal mitochondria is stimulated equally by physiological levels of free calcium and by GTP. Mol Cell Endocrinology 107: 181-188, 1995 32. Kern TS, Kowluru RA, Engerman RL: Questions raised by studies of experimental diabetic retinopathy. In Diabetes 1994; Proceedings of 15th International Diabetes Federation Congress, Baba S and Tanako T. eds. Kobe, Japan, Excerpta Medica, pp 331-334, 1995 33. Kowluru RA, Kern TS, Engerman RL, Armstrong D: Abnormalities of retinal metabolism in diabetes and galactosemia. III. Effects of antioxidants. Diabetes 45: 1233-1237, 1996

34. Kern TS, Kowluru RA, Engerman RL: Dog and rat models of diabetic retinopathy. In Lessons in Animal Diabetes. E Shafrir, ed. London, Smith-Gordon, Boston: Birkhauser, 395-408, 1996

35. Kowluru RA, Kern TS, Engerman RL: Abnormalities of retinal metabolism in diabetes and galactosemia. IV. Antioxidant defense system. Free Rad Biol Med 22: 587-592, 1997

36. Kowluru RA, Jirousek MR, Stramm L, Farid N, Engerman RL, Kern TS: Abnormalities of retinal metabolism in diabetes and galactosemia. V. Relationship between diabetes-induced alterations in retinal protein kinase C and ATPases in rats. Diabetes 47: 464-469, 1998 37. Kowluru A, Kowluru RA: Subcellular localization and characterization of nucleoside diphosphate kinase in rat retina: Effect of diabetes. Bioscience Reports 4: 187-198, 1998


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38. Kowluru RA, Engerman RL, Kern TS: Abnormalities of retinal metabolism in diabetes and galactosemia. VI. Comparison of retinal and cerebral cortex metabolism, and effects of antioxidant therapy. Free Rad Biol Med 26: 371-378, 1999 39. Berkowitz BB, Kowluru RA, Frank RN, Kern TS, Hohman TC, Prakash M: Subnormal retinal oxygenation response precedes diabetic-like retinopathy. Inves Ophthal Vis Sci 40: 2100-2105, 1999

40. Kowluru RA, Jirousek MR, Stramm L, Farid N, Engerman RL, Kern TS: Abnormalities of retinal metabolism in diabetes and galactosemia. V. Relationship between diabetes-induced alterations in retinal protein kinase C and ATPases in rats. In Focus on Diabetic Retinopathy. Bijesterveld OP ed Netherlands, Excerpta Medica 6: 38-39, 1999 41. Kowluru RA, Engerman RL, Kern TS: Diabetes-induced metabolic abnormalities in heart. Free Radical Research 32: 67-74, 2000 42. Kern TS, Tang J, Mizutani M, Kowluru RA, Nagraj R, Lorenzi M: Response of capillary cell death to aminoguanidine predicts the development of retinopathy: Comparison of diabetes and galactosemia. Inves Ophthal Vis Sci 41: 3972-3978, 2000 43. Kowluru RA, Engerman RL, Kern TS: Abnormalities of retinal metabolism in diabetes and galactosemia. VII. Prevention by aminoguanidine. Current Eye Research 21: 814-819, 2000 44. Kowluru RA, Engerman RL, Case GL, Kern TS: Retinal glutamate in diabetes and effect of antioxidants. Neurochem International 38: 385-390, 2001

45. Kowluru RA, Tang J, Kern TS: Abnormalities of retinal metabolism in diabetes and galactosemia. VII. Effect of long-term administration of antioxidants on retinal oxidative stress and the development of retinopathy. Diabetes 50: 1938-1942, 2001

46. Kowluru RA: Diabetes-induced elevation in retinal oxidative stress, protein kinase C and nitric oxide are inter-related. Acta Diabetologica 38: 179-185, 2001 47. Kowluru RA, Kennedy A: Therapeutic potential of antioxidants and diabetic retinopathy. Expert Opinion Investigational Drugs 10: 1665-1676, 2001 48. Kowluru RA, Koppolu P: Diabetes-induced activation of Caspase-3: Effect of antioxidants therapy. Free Radical Research 36: 993-999, 2002 49. Kowluru RA: Retinal metabolic abnormalities in diabetic mouse: comparison with diabetic rat. Current Eye Research 24: 123-128, 2002 50. Kowluru RA, Koppolu P: Termination of experimental galactosemia in rats, and progression of retinal metabolic abnormalities. Inves Ophthal Vis Sci 43: 3287-3291, 2002


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51. Kowluru RA: Effect of re-institution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats. Diabetes 52: 818-823, 2003 53. Kowluru RA, Tang J, Kern TS: Abnormalities of retinal metabolism in diabetes and experimental galactosemia. VII. Effect of long-term administration of antioxidants on the development of retinopathy. In Focus on DiabeticRetinopathy. Bijesterveld OP ed. Netherlands. Excerpta Medica 10: 19-20, 2003 54. Kowluru RA, Koppolu P, Chakrabarti S, Chen S: Diabetes-induced activation of nuclear transcriptional factor in the retina, and its inhibition by antioxidants. Free Radical Research 37: 1169-1180, 2003 55. Kowluru RA, Abbas SN: Diabetes-induced mitochondrial dysfunction in the retina. Inves Ophthal Vis Sci 44: 5327-5334, 2003 56. Luan H, Liggett M, Gupta RR, Pacheco D, Seidner A, Liggett J, Ito Y, Kowluru R, Berkowitz BA: Diabetic PKC βII knockout mice show regionally specific correction of the early subnormal retinal oxygenation response. Inves Ophthal Vis Sci 45: 937-942, 2004 57. Kowluru RA, Kowluru A, Chakrabarti S, Khan Z: Potential contributory role of H-Ras, a small G-protein, in the development of retinopathy in diabetic rats. Diabetes 53:775-783, 2004 58. Kowluru RA, Odenbach S: Role of interleukin-1β in the pathogenesis of diabetic retinopathy. British J Ophthalmology 88:1343-1347, 2004 59. Kowluru RA, Abbas SN, Odenbach S: Reversal of hyperglycemia and diabetic nephropathy: Effect of re-institution of good metabolic control on oxidative stress in the kidney of diabetic rats. J Diabetes & its Complications 18:282-288, 2004 60. Kowluru RA, Odenbach: Role of interleukin-1β in the development of diabetic retinopathy in rats: effect of antioxidants. Inves Ophthal Vis Sci 45:4161-4166, 2004 61. Kowluru RA, Odenbach S: Effect of long-term administration of alpha lipoic acid on retinal capillary cell death and the development of retinopathy in diabetic rats. Diabetes 53:3233-3238, 2004 62. Kowluru RA, Chakrabarti S, Chen S: Re-institution of good metabolic control in diabetic rats and activation of caspase-3 and nuclear transcriptional factor in the retina. Acta Diabetologica 44:194-199, 2004 63. Kowluru RA: Effect of advanced glycation end products on accelerated apoptosis of retinal capillary cells under in vitro conditions. Life Sciences 76:1051-60, 2005 64. Kowluru RA: Diabetic retinopathy: Mitochondrial dysfunction and retinal capillary cell death. Antioxidants & Redox Signaling 7:1581-1587, 2005


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65. Kowluru RA: Diabetic retinopathy, oxidative stress and antioxidants. Current Topics in Nutraceutical Research 3/4: 209-218, 2005 66. Kowluru RA, Atasi L, Ho Y-S: Role of mitochondrial superoxide dismutase in the development of diabetic retinopathy. Invest Ophthal Vis Sci 47:1594-1599, 2006 67. Kowluru RA, Kowluru V, Xiaong YS, Ho YS: Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes- induced oxidative stress. Free Rad Biol Med 41: 1191-1196, 2006 68. Cheng DW, Jiang Y, Shalev A, Kowluru R, Crook ED, Singh LP: An analysis of high glucose and glucosamine-induced gene expression and oxidative stress in renal mesangial cells. J Arch Physiol Biochem 118:189-212, 2006 69. Singh LP, Cheng DW, Kowluru R, Levi E, Jiang Y: Hexosamine induction of oxidative stress, hypertrophy and laminin expression in renal mesangial cells: effect of antioxidant α-lipoic acid. Cell Biochem Func 25:537-550, 2007 70. Kowluru RA, Kowluru A, Kanwar M: Role of small molecular weight G-protein, H-Ras, in retinal capillary cell death in diabetes. Molecular and Cellular Biochemistry 396:69-76, 2007 71. Kowluru V, Kowluru RA: Increased oxidative stress in diabetes regulates activation of a small molecular weight G-protein, H-Ras, in the retina. Molecular Vision 13:602-610, 2007 72. Kowluru RA, Kanwar M: Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutrition & Metabolism (Lond) 4:8, 2007 73. Kanwar M, Chan PS, Kern TS, Kowluru RA: Oxidative damage in the retinal mitochondria of diabetic mice: Possible protection by superoxide dismutase. Invest Ophthal Vis Sci 48: 3805-3811, 2007 74. Chan PS, Kowluru RA: Role of retinal mitochondria in the development of diabetic retinopathy. Expert Review of Ophthalmology 2:237-247, 2007 75. Kowluru RA, Kanwar M, Kennedy A: Metabolic Memory phenomenon and accumulation of peroxynitrite in retinal capillaries. Exp Diabetes Res 2197, 2007 76. Kowluru RA, Chan PS: Oxidative stress and diabetic retinopathy. Exp Diabetes Res 43603, 2007 77. Kowluru RA, Menon B, Gierhart D: Beneficial effect of zeaxanthin on retinal metabolic abnormalities in diabetic rats. Invest Ophthal Vis Sci 49:1645-1651, 2008 78. Kowluru RA, Kanwar M: Anti-oxidants and diabetic retinopathy. Proceedings of 7th International Symposium on Ocular Pharmacology and Therapeutics, Budapest, Hungary, 53-59, 2008


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79. Kanwar M, Kowluru RA: Diabetes regulates small molecular weight G-protein, H-Ras, in the microvasculature of the retina: Implication in the development of retinopathy. Microvascular Research, Apr 25 [Epub ahead of print], 2008 80. Kowluru RA, Chan PS: Capillary drop-out in diabetic retinopathy, chapter for book entitled ‘Diabetic Retinopathy’, Humana Press, NJ, in press, 2008 81. Rayappa S, Kowluru RA: Role of Raf-1 kinase in diabetes-induced accelerated apoptosis of retinal capillary cells. Intern J of Biomed Sci 4:20-28, 2008 82. Madsen-Bouterse S, Kowluru RA: Oxidative stress and diabetic retinopathy: pathophysiological mechanisms and treatment perspectives. Reviews in Endocrine and Metabolic Disorders, Jul 25 [Epub ahead of print], 2008 83. Kowluru RA, Kanwar M, Chan PS, Zhang JP: Inhibition of retinopathy and retinal metabolic abnormalities in diabetic rats with AREDS-based micronutrients. Arch Ophthalmol, in press, 2008 84. Chan PS, Kanwar M, Kowluru RA: Inflammatory mediators in the retina resist suppression after re-institution of good glycemic control in diabetic rats. 2008, under review 85. Kowluru RA, Kanwar M: Potential contributory role of matrix metalloproteinase-2 in the development of diabetic retinopathy. 2008, under review 86. Kanwar M, Kowluru RA: Role of glyceraldehyde 3-phosphate dehydrogenase in the development and progression of diabetic retinopathy. 2008, under review


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PUBLISHED ABSTRACTS 1. Puri RB, Sahib MK, Kidwai JR: Correlation between pancreatic lysosomal marker enzyme activities and insulin content in rat. 45th Annual Meeting of Society of Biological Chemists, Calcutta, India 1975 2. Puri RB, Anjaneyulu K, Kidwai JR, Rao VKM: Effect of different amino acids on acid phosphatase, cathepsin-B activities and insulin content in rat pancreas. 46th Annual Meeting of Society of Biol. Chemists, Hyderabad, India, 1976 3. Anjaneyulu K, Puri RB, Dua RD, Singh C: Fluorescence changes in amylases with some metal coordinates. 46th Annual Meeting of Society of Biological Chemists, Hyderabad, India 1976 4. Puri RB, Anjaneyulu K, Kidwai JR, Rao VKM: Role of cathepsin-B in the conversion of pro-insulin to insulin. 47th Annual Meeting of Society of Biological Chemists, Madras, India, 1977 5. Anjaneyulu K, Puri RB, Dua RD, Singh C: Response of modified and immobilized alpha-amylase to its activators. 47th Annual Meeting of Society of Biological Chemists, Madras, India 1977 6. Puri RB, Anjaneyulu K, Kidwai JR, Rao VKM: Effect of centpiperalone on the activities of acid phosphatase, cathepsin-B and insulin content in the islets of Langerhans of rat. Proceedings of All India Symposiums on Metabolism and Disposition of Xenobiotics, Aurangabad, India, 1977 7. Anjaneyulu K, Puri RB, Dua RD, Singh C: Studies on the effect of neomycin and polyamines on some pancreatic enzymes and insulin content in rats. Proceedings of All India Symposium on Metabolism and Disposition of Xenobiotics, Aurangabad, India, 1977 8. Puri RB, Anjaneyulu K, Sahib MK, Kidwai JR: Effect of streptozotocin on the activity of cathepsin-B and insulin content in rat. Federation Proceedings of Indian Society of Endocrinology, Central Drug Research Institute, Lucknow, India 1977 9. Anjaneyulu R, Anjaneyulu K: Purification, properties, and characterization of cathepsin-B from islets of Langerhans of rat pancreas. 48th Annual Meeting of Society of Biological Chemists, Delhi, India, 1978 10. Anjaneyulu R, Viswanathan R: Studies of certain enzymes of rat exposed to hypoxia. 48th Annual Meeting of Society of Biological Chemists, Delhi, India, 1978 11. Anjaneyulu K, Anjaneyulu R, Malaisse WJ: Ionophoretic transport of cations by islets extracts. Presented at the Contact Group Meeting on “Endocrine Pancreas” at University of Brussels, 1979


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12. Anjaneyulu K, Anjaneyulu R, Valverde I, Sener A: Significance of glutathione metabolism in pancreatic islets. 16th European Association of Study of Diabetes, Athens, Greece, 1980

13. Couturier E, Anjaneyulu R, Anjaneyulu K, Dleers M, Malaisse WJ: Effect of gliclazide and diazoxide upon ionophore mediated calcium counter transport. European Association for the Study of Diabetes, Athens, Greece, 1980

14. Anjaneyulu R, Anjaneyulu K, Sener A, Malaisse WJ: Mannose metabolism in pancreatic islets. Diabetes 30: A115, 1981

15. Kowluru RA, Porter JW: Inactivation of Acetyl CoA Carboxylase by glucagons in a cell free system obtained from rat liver. Diabetes 31: A56, 1982

16. Kowluru RA, Jefcoate CR: Activation and reconstitution of cytochrome P-450 scc by diphosphoinositide. Fed Proc 42: 122A, 1983

17. Kowluru RA, Privalle CT, Jefcoate CR: Control of cholesterol movement of cytochrome P450 scc in rat adrenal mitochondria. Fed Proc 43: 339A, 1984

18. Narasimhulu S, Diabartolomeis M, Kowluru RA, Jefcoate CR: On the purification of P-450 C-21 from bovine adrenocortical microsomes. VI International Meeting on Microsomes during oxidation, Brighton, 1984

19. Kowluru A, Kowluru RA, Bitensky MW, Johnson JD, Greenberg R, Kelly RO: Glycosylation of erythrocyte cytoskeleton proteins in diabetes. Fed Proc 44: 4994A, 1985

20. Kowluru A, Kowluru RA, Bitensky MW: Nonenzymatic glycosylation of erythrocyte cytoskeletal proteins in diabetes mellitus. Gioranle Italino di Diabetologia 5: 401, 1985

21. Lehnert BE, Kowluru RA, Kowluru A, Tillery SI, Bitensky MW: Alterations in alveolar macrophage cytoskeletal proteins and functions during diabetes mellitus. Amer Rev Respir Dis 133: 140A, 1986

22. Johnson JD, Trissell S, Kowluru A, Kowluru RA, Bitensky MW: Red cell function in fetuses of diabetic mothers: Decreased life span and deformability associated with increased nonenzymatic glucosylation of red cell membrane proteins. Pediatric Research 20: 413A, 1986

23. Kowluru RA, Kowluru A, Bitensky MW: Nonenzymatic glucosylation of neuronal calmodulin and its functional consequences. Fed Proc 45: 1241A, 1986

24. Bitensky MW, Kowluru A, Kowluru RA: Increased cross-linking of proteins in diabetes. Fed Proc 45: 2080A, 1986

25. Kowluru A, Kowluru RA, Johnson J, Greenberg R, Bitensky MW: Preferential excretion of glucosylated albumin in normal and diabetic individuals. Diabetes 35: A93, 1986


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26. Kowluru RA, Kowluru A, Bitensky MW: Kinetics and mechanism of loss of preferential urinary excretion of glucosylated albumin in the diabetic rat. Diabetes 35: A120, 1986

27. Bitensky MW, Kowluru RA, Kowluru A, Valdez YE, Tillery SI, Lehnert BE: Structural and functional alternations in alveolar macrophages during diabetes mellitus. Proceedings of the Endocrine Society Meetings 106:301A, 1986

28. Downer NW, Kowluru A, Kowluru RA, Bitensky MW, Heidorn DB, Trewhella J: Effects of glucosylation on calcium binding of calmodulin structure studies by small angle x-ray scattering. Biophys J 51454A, 1987

29. Kowluru RA, Bitensky MW, Kowluru A: Decreased RBC ouabain sensitive Na – K ATPase activity in diabetes. Diabetes 37: A72, 1988

30. Kowluru A, Bitensky MW, Kowluru RA: An age dependent change in glomerular charge. Diabetes 38: A119, 1989

31. Bitensky MW, Kowluru RA, Kowluru A, Dembo M: A new approach in the practice of transfusion science based upon the body’s method for removing aged red blood cells. Defense Applications Program Fair. Los Alamos National Laboratory, Los Alamos, 1989

32. Bitensky MW, Kowluru RA, Kowluru A: A parameter that predicts the survival of transfused red blood cells. Defense Applications Program Fair. Los Alamos National Laboratory, Los Alamos, 1989.

33. Kowluru RA, Bitensky MW, Kowluru A: Regulation of Na pump activity in diabetic red blood cells by insulin. Diabetes, 39: A256, 1990

34. Kowluru RA, Kowluru A, Yamazaki A: Altered erythrocyte G-protein metabolism in diabetes. Fed Proc 5:3151A, 1991

35. Kowluru RA and Kowluru A: Erythrocyte sodium-potassium ATPase activity and thiol metabolism in genetically hyperglycemic mice. Diabetes 41: A127, 1992

36. Kowluru RA, Kern TS, Engerman RL: Ciliary body (Na,K)-ATPase activity in diabetes and galactosemia. Diabetes 42: A190, 1993.

37. Kern TS, Kowluru RA, Engerman RL: Subnormal calcium ATPase activity and glutathione in retinas of diabetic dogs and galactosemic dogs. Diabetes 42: A190, 1993

38. Kowluru RA, Kern TS, Engerman RL: Retinal ATPase and glutathione: Effects of diabetes, galactosemia and aldose reductase inhibition. Inves Ophthal Vis Sci 35: S1587, 1994.

39. Kowluru RA, Kern TS, Engerman RL: Metabolic abnormalities in retinas of diabetic rats: Treatment with antioxidants or a calcium channel blocker. Diabetes 43: A112, 1994


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40. Kowluru RA, Kern TS, Engerman RL: Antioxidants prevent retinal glutathione dysmetabolism in diabetes. Inves Ophthal Vis Sci 36: S1066, 1995

41. Kern T, Kowluru RA, Engerman R: Disparity of (Na,K)-ATPase, myoinositol and nerve conduction velocity (NCV) in canine diabetes and galactosemia. Diabetes 44: A65, 1995

42. Kowluru RA, Kern T, Engerman RL: Antioxidant therapy corrects subnormal free radical defense mechanism in diabetic retina. Diabetes 44: A117, 1995

43. Kowluru RA, Kern TS, Engerman RL: Retinal metabolic abnormalities of diabetic mice and galactosemic mice. Inves Ophthal Vis Sci 36:S970, 1996

44. Kern TS, Kowluru RA, Engerman RL: Effects of antioxidants on the development of retinopathy in diabetes and galactosemia. Inves Ophthal Vis Sci 36: S970, 1996

45. Kowluru RA, Jirousek MR, Stramm L, Engerman RL, Kern TS: Diabetes-induced disorders of retinal protein kinase C and Na,K-ATPase are inhibited by LY333531. Diabetes 45: A16, 1996

46. Beyer-Mears A, Cruz E, Kowluru RA, Engerman R, Kern TS: Short term effects of vitamin C plus vitamin E on diabetic albuminuria and proteinuria. Diabetes 45: A206, 1996

47. Kowluru RA, Kern TS: Effect of antioxidant therapy on protein kinase C activity in retina and nerve of diabetic rats and galactose-fed rats. Presented at 32nd Research Symposium on the Role of Antioxidant Therapy in Diabetic Complications, Nov 1996, Orlando, FL

48. Kowluru RA, Engerman RL, Kern TS: Oxidative stress and protein kinase (PKC) are inter-related in retinas of diabetic rats and galactose-fed rats. Diabetes 46: A9, 1997

49. Kowluru RA, Engerman RL, Kern TS: Antioxidant (AO) supplementation in diabetes normalizes disparate alterations in protein kinase C (PKC) activity in heart and sciatic nerve. Diabetes 46: A156, 1997

50. Kern TS, Kowluru RA, Jirousek MR, Stramm L: Protein kinase C in retinal microvessels of diabetic or galactosemic rats. Diabetes 46: A10, 1997

51. Kowluru RA: Hyperglycemia-induced retinal metabolic abnormalities are inter-related. EASD/JDF Oxford Workshop on Diabetic Retinopathy, Sep 1997, Oxford, UK

52. Kowluru RA, Lieth E, Engerman RL, Kern TS, Ratz MJ, Xu B, Lanoue KF: Antioxidants inhibit diabetes-induced elevation in retinal glutamate. Diabetes 47: A141, 1998

53. Kowluru RA, Engerman RL, Kern TS: Inter-relationship of hyperglycemia-induced increases of oxidative stress, protein kinase C, nitric oxide and glutamate in the retina. Diabetes 47: A141, 1998


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54. Lieth E, Ratz MJ, Lanoue KF, Xu B, Kowluru R, Kern TS, Gardner TW, Barber AJ, Antonetti DA: Elevated glutamate in retinas of short-term diabetic rats. Inves Ophthal Vis Sci 39: S826, 1998

55. Kowluru RA, Engerman RL, Kern TS: Effects of aminoguanidine (AG) on hyperglycemia-induced retinal metabolic abnormalities. Diabetes 48: A19, 1999 56. Kern TS, Kowluru RA: Effect of Aminoguanidine on the development of retinopathy in diabetic rats and galactosemic rats. Diabetes 48: A153, 1999 57. Kowluru RA: Retinal dysmetabolism continues to progress after hyperglycemia is reversed. Diabetes 49: A171, 2000 58. Kowluru RA, Kern TS: Antioxidants inhibit the development of retinopathy in diabetic rats and in galactose-fed rats. Inves Ophthal Vis Sci 42: S208, 2001 59. Kowluru RA, Kern TS: Long-term administration of antioxidants inhibits the development of retinal histopathology in diabetes. Diabetes 50: A17, 2001 60. Chen H-Q, Kowluru RA: Antioxidants inhibit hyperglycemia-induced activation in caspase-3 in the retina. Diabetes 50: A191, 2001 61. Kowluru RA, Chakrabarti S, Chen S: Nuclear transcriptional factor (NF-kB) remains activated in the retina of diabetic rats when retinopathy is developing, and antioxidants inhibit this activation. Diabetes 51: A201, 2002 62. Kowluru RA: Protein kinase C and retinal capillary cell death in diabetes. Diabetes 51: A205, 2002 63. Koppolu P, Zhou X, Kowluru RA: Excretion of lipid peroxides and nitric oxides is inhibited after normoglycemia is re-instituted. Diabetes 51: A205, 2002 64. Kowluru RA, Chen S, Chakrabarti S: Antioxidants inhibit diabetes-induced activation of retinal nuclear transcriptional factor (NF-kB). Presented at annual meeting of the Association for Research in Vision and Ophthalmology, 2002 65. Luan H, Kowluru RA, Koppolu, Gupta R, Pacheco D, Leitges M, Ito Y, Berkowitz B: PKC BII and the subnormal retinal oxygenation response in galactose-fed mice. Presented at annual meeting of the Association for Research in Vision and Ophthalmology, 2002 66. Kowluru RA: Mitochondrial oxidative stress and retinal capillary cell death in diabetes. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, 2003 67. Kowluru RA: Effect of re-institution of good glycemic control in diabetic rats on retinal caspase-3 activation. Diabetes 52: A202, 2003


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68. Kowluru RA: Role of mitochondrial oxidative stress in the development of diabetic retinopathy. Diabetes 52: A202, 2003 69. Kowluru RA, Odenbach S: Interleukin-1 beta and retinal microvascular cell death in diabetes. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, 2004 70. Kowluru RA, Odenbach S: Role of interleukin 1 beta in retinal microvascular cell death. Diabetes 53: A217, 2004 71. Kowluru RA: Advanced glycation end products and retinal capillary cell death. Diabetes 53: A218, 2004 72. Odenbach S, Abbas SN, Kowluru RA: Re-institution of good metabolic control in diabetes and reversal of renal abnormalities. Diabetes 53: A505, 2004 73. Kowluru RA, Odenbach S: Interleukin-1 beta and diabetic retinopathy. Diabetologia 47: A381, 2004 74. Abrams G, Kowluru RA: Role of Hyperglycemia and oxidative stress in development of diabetic retinopathy. Presented at the meeting Association for Research in Vision and Ophthalmology-Asia, 2005 75. Kowluru RA, Odenbach S, Basak S: Long-term administration of lipoic acid inhibits retinopathy in diabetic rats via regulating superoxide dismutase. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, 2005 76. Kowluru RA, Basak S: Lipoic acid inhibits retinal histopathology in diabetic rats via regulating mitochondrial superoxides. Diabetes 54: A222, 2005 77. Kowluru RA, Basak S: Overexpression of MnSOD in retinal endothelial cells inhibits their apoptosis. Diabetes 54: A224, 2005 78. Kowluru RA, Kowluru A, Kanwar M: Role of Small Molecular Weight G-protein Ras in the Development of Diabetic Retinopathy. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, 2006 79. Gierhart D, Kowluru RA: Administration of zeaxanthin inhibits diabetes-induced metabolic abnormalities in the retina. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, 2006 80. Kowluru RA, Kowluru R, Kanwar M: Role of small molecular weight G-protein Ras in the development of diabetic retinopathy. Diabetes 55: A53, 2006


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81. Kowluru RA, Kanwar M: Curcumin prevents diabetes-induced retinal abnormalities: possible implications for diabetic retinopathy. Presented at the meeting of the International Diabetes Federation, 2006 81. Kanwar M, Kowluru RA: Role of mitochondria in the development of diabetic retinopathy. Presented at the meeting of the International Diabetes Federation, 2006 82. Kowluru RA, Kanwar M: Continued damage to the retinal microvasculature and progression of diabetic retinopathy. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, 2007 83. Kanwar M, Kowluru RA: Mitochondrial superoxide and diabetic retinopathy. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, 2007 84. Glybina I, Kanwar M, Iezzi R, Abrams GW, Kowluru RA: Effects of AREDS-based nutritional supplements in albino RCS rats. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, 2007 86. Kowluru RA, Kanwar M: Metabolic memory and retinal dysmetabolism in mouse model of diabetic retinopathy. Diabetes 56: A216, 2007 85. Kowluru RA, Kanwar M: Diabetic retinopathy and mitochondrial damage in the retina. Diabetes 56: A217, 2007 88. Kanwar M, Kowluru RA: G-protein H-Ras in retinal microvessels and its role in the development of diabetic retinopathy. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, 2008 89. Chan PS, Kowluru RA: Role of MMP-9 in inflammation and apoptosis of retinal capillary cells in diabetes. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, 2008 90. Kowluru RA, Chan PS, Kanwar M: Resistance of Retinal inflammatory mediators to arrest after re-institution of good glycemic control in diabetic rats. Presented at the annual meeting of the Association for Research in Vision and Ophthalmology, 2008 91. Kanwar M, Kowluru RA: Inflammation is important in the progression of diabetic retinopathy. Diabetes 57: A236, 2008 92. Chan PS, Kowluru RA: Metabolic memory and apoptotic markers in the retina. Diabetes 57: A237, 2008


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PRESENTATIONS Invited and/or Refereed Meetings and Seminars 1999 Annual Meeting and Scientific Session off the American Diabetes Association; San Diego, CA; ‘Effects of aminoguanidine on hyperglycemia-induced retinal metabolic abnormalities.’ 2000 Invited speaker, Esperion Corporation, Ann Arbor, MI; ‘Diabetic retinopathy and metabolic abnormalities’ 2001 Research Seminar, Kresge Eye Institute; ‘Role of abnormal metabolism in the development of diabetic retinopathy.’ 2001 Annual Meeting and Scientific Session off the American Diabetes Association; Philadelphia; PA, ‘Long-term administration of antioxidants inhibits the development of retinal histopathology in diabetes’. 2002 Annual Meeting of the Association for Research in Vision and Ophthalmology; Ft Lauderdale, FL; Antioxidants inhibit diabetes-induced activation of retinal nuclear transcriptional factor.’ 2003 Invited speaker, National University of Singapore, Singapore; ‘Role of oxidative stress in the development of diabetic retinopathy.’ 2003 Invited seminar, Anatomy and Cell Biology Department; Wayne State University; ‘Diabetic retinopathy and oxidative stress.’ 2004 Invited lecture, Oakland University, Oakland, MI; ‘Diabetic retinopathy and vascular disease.’ 2004 Invited speaker, Anatomy and Cell Biology Department; Wayne State University; ‘Pathogenesis of retinopathy in diabetes: Potential cellular mechanisms’. 2004 Invited speaker, Oakland University, Oakland, MI; ‘Retinal Dysmetabolism and Retinopathy in Diabetes.’ 2004 Invited speaker at the annual meeting of the Indian Society for Atherosclerosis Research, Trivendrum, India; ‘Inflammation and retinopathy in diabetes.’ 2005 Invited lecture, Oakland University, Oakland, MI; ‘Diabetic retinopathy and vascular disease.’ 2005 Invited speaker, Veterans Administration Hospital, Detroit, MI; ‘Pathogenesis of diabetic retinopathy’


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2006 Invited lecture, Oakland University, Oakland, MI; ‘Diabetic retinopathy and vascular disease.’ 2006 ‘Role of small molecular weight G-protein Ras in the development of diabetic retinopathy’; American Diabetes Association's 66th Scientific Sessions, Washington DC 2007 Invited speaker, Michigan State University, Lansing, MI; ‘Role of mitochondria in the pathogenesis of diabetic retinopathy’ 2007 Invited lecture, Oakland University, Oakland, MI; ‘Diabetic retinopathy and vascular disease.’ 2007 Annual meeting of the Association for Research in Vision and Ophthalmology, Ft Lauderdale, FL; ‘Continued damage to the retinal microvasculature and progression of diabetic retinopathy’.

2008 Invited speaker, Institute of Environmental Health Sciences, Wayne State University, MI; ‘Mitochondrial dysfunction and diabetic retinopathy’. 2008 Visiting Professor, Kellogg Eye Center, University of Michigan, Ann Arbor, MI; ‘Good glycemic control and progression of diabetic retinopathy’. 2008 Invited speaker, 7th International Symposium on Ocular Pharmacology and Therapeutics, Budapest, Hungary “Antioxidants and diabetic retinopathy’. 2008 Invited lecture, Oakland University, Oakland, MI; ‘Diabetic retinopathy and vascular disease.’ 2008 Invited speaker, Diabetes Research Conference, Division of Endocrinology, Wayne State University; ‘Metabolic Imprinting and Progression of Diabetic Retinopathy’.


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GRANT SUPPORT (Active) Source: National Institutes of Health Title: Glycemic Control and Progression of Diabetic Retinopathy Grant Period: 3/01/2007-2/29/2012 Role: Principal Investigator Specific Objectives: To understand the mechanism responsible for the tendency of incipient retinopathy to continue to progress. Source: Juvenile Diabetes Research Foundation Title: ‘Role of Inflammation in the Progression of Diabetic Retinopathy’ Grant period: 11/01/2006-10/31/2009 Role: Principal Investigator Specific Objectives: This project is to investigate the role of cytokines in the resistance of retinopathy to reverse after re-establishment of good glycemic control in diabetes. Source: National Institutes of Health Title: Role of Retinal Cell Death in Diabetes Grant Period: 09/04-08/08 Role: Principal Investigator Specific Objectives: This project examines contributory roles for Ras in apoptotic cell death of the retinal capillary endothelial cells. Source: Juvenile Diabetes Research Foundation Title: ‘Role of Oxidative Stress in the Development of Diabetic Retinopathy’ Grant period: 04/01/2004-03/31/2008 Role: Principal Investigator Specific Objectives: This project is to investigate the role of diabetes-induced increased oxidative stress and superoxide on the specific signaling steps leading to retinal capillary cell death in diabetes. Source: The Thomas Foundation Title: ‘Metabolic Abnormalities and Diabetic Retinopathy’ Grant period: 01/01/2000-12/31/2008 Role: Principal Investigator Specific Objectives: This proposal investigates the retinal metabolic abnormalities, including inflammation and transcriptional factors that could contribute to retinal capillary cell death in diabetes. Source: Midwest Eye Banks and Transplantation Center Project to investigate the role of inflammatory markers in the resistance of diabetic retinopathy to reverse after reinstitution of good glycemic control Grant period: 2007-2008 Role: Mentor (student award-Pooi-See Chan, PhD)


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Source: Midwest Eye Banks and Transplantation Center Project to investigate the diabetes-induced covalent modifications of GAPDH in retinal capillary cells Grant period: 2008-2009 Role: Mentor (student award-Sally Madsen-Bouterse, PhD)

(Approved for funding) Source: Juvenile Diabetes Research Foundation Title: ‘Oxidative Stress and Diabetic Retinopathy: Matrix Metalloproteinase-2’ Grant period: 12/01/2008-11/30/2011 Role: Principal Investigator Specific Objectives: This project is to investigate the role matrix metalloproteinases and oxidative stress in retinal capillary cell death in diabetes.

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