7/24/2019 Repair and Regeneration of Oral Tissues Ten Cate Chapter 15

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Repair and Regeneration of Oral Tissues Ten Cate Chapter15

1. Diference between regeneration and repaira. Regeneration the complete restoration o tissue

architecture and unctionb. Repair restoration o unction and o tissue continuity

BUT with distortion o the normal architecture

Wound healing in Oral Mucosa- !in and oral mucosa ha"e the primary unction o protecting

the underlying tissues rom #$s and to%ins- The oral mucosa can be damaged by& direct physical insult'

radiation' chemical irritation' colonisation by microorganisms.

Initial response to wound healing- ()*#$T)+- ,hen the mucosal surace is damaged there is "ascular

damage and haemorrhaging into the tissue deecto +BR+ deposited' /0)T*0*T aggregation' 0$T

ormationo Time rame& #+UT*

- UT+$ o 0$To to unite the wound margins and protect rom e%posed

tissueso pro"isional 2scafold3 or subse4uent migration o

R*/)R)T+5* *00- #oist en"ironment means clot is not hard and dry li!e that in

s!in' rather it is a $T $)6U0)# that is easily lost.o The integrity o the clot as a protecti"e barrier is

compromised ater se"eral minuteso This is due to

5)$D+0)T+$ and +R*)*D 5)U0)R

/*R#*)B+0+T7 allow /0)#) /R$T*+ to enterthe wound site and this stimulates 0*U8$7T*#+6R)T+$

- #$s' to%ins' and antigens are also li!ely to ha"e entered intothe mucosal tissues leading to an +0)##)T$R7 R*/$*

Inammatory cell actiation! migration! and function- +mmediate acute in9ammatory reaction- +n9ammatory cells come rom

o ells normally present in tissueso ells e%tra"sated when B5s are damaged

o ells carried in intact B5s ad:acent to a wound that e%itby a process called diapedesis.

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hemota%is is the process by which platelet

deri"ed cyto!ines recruit leu!ocytes to the site otissue damage

- #a:or cells in"ol"ed in in9ammation and wound healingo /#s

#ainly *UTR$/(+0 the +RT to in"ade thewound

Time rame& a *, ($UR

)cti"ation& phagocytic stimuli $R binding o

chemotactic mediators' antigen-antibodycomple%es to speci;c receptors on the cellmembrane' and components o the complementsystem.

#a% concentration

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0ymphocyte chemota%is is macrophagerelated

o #ast cells

+mportant source o /R$+0)##)T$R7 mediators

and 7T$8+* /romotes in9ammation and "ascular changes

Reparatie phase- The acute in9ammatory phase needs to subside to ensure

successul repair o the in:ured tissues.- Regeneration o the tissues begins ;rst in epithelium and then

in the connecti"e tissue- #obilisation and migration o epithelial cells at the wound

margino ells lose their close attachment to each other and to

the underlying T within