Report of President 2011/2012 - School of

Biomolecular & Biomedical Science

>> Book Chapters

>> Books Edited

>> Peer Reviewed Journals

>> Conference Publications

Book Chapters

Professor Steffen Backert

Tegtmeyer N, Rohde M, Backert S (2012) 'Clinical presentations and pathogenicity

mechanisms of bacterial foodborne diseases' In: O.A. Oyarzabal & S. Backert (eds).

Microbial Food Safety. New York London: Springer Verlag.

Oyarzabal OA, Backert S (2012) 'Food safety resources' In: O.A. Oyarzabal & S.

Backert (eds). Microbial Food Safety. New York London: Springer Verlag.

Professor Geraldine Butler

Butler G, Lorenz M, Gow NAR (2012) 'Evolution and genomics of the pathogenic

Candida species complex' In: L. David Sibley, Barbara J. Howlett, Joseph Heitman

(eds). Evolution of Virulence in Eukaryotic Microbes. New Jersey: Wiley-Blackwell.

Butler, G; (2012) 'Comparative genomics of Candida species' In: Candida and

Candidiasis, 2nd edition. Washington, DC: ASM Press.

Dr Gerard Cagney

Ryan C, Cagney G, Krogan NJ, Cunningham P, Greene D (2011) ''Imputing and

predicting quantitative genetic interactions in epistatic MAPs' In: Network Biology:

Methods and Applications (Methods in Molecular Biology). USA: Springer Verlag.

Dr Tara McMorrow

O'Connell S, Nolan S, Slattery C, Ryan MP, McMorrow T. (2012) 'The role of

Transglumatinase in Kidney Disease' In: Fibronectin and Disease. Croatia: Intech.

Slattery C, Cassidy H, Johnston O, Ryan MP and McMorrow T (2012) 'Mechanisms of

calcineurin inhibitor nephrotoxicity in chronic allograft injury' In: Chronic Kidney

Disease and Renal Transplantation. India: Research Signpost.

Dr Cormac Declan Murphy

Brennan L, Mostaert A, Murphy C & Owende, P (2012) 'Phytochemicals from Algae'

In: Carrier J, Ramaswamy S, Bergeron C (eds). Biorefinery Co-Products:

Phytochemicals, Primary Metabolites and Value-added Biomass Processing. Chicester:

Wiley.

Dr Keith Murphy

O'Sullivan NC, Sheridan GK, Murphy KJ; (2012) 'Transcriptional profiling of

hippocampal memory-associated synaptic plasticity: Old friends and new faces' In:

Transcription Factors CREB and NF-κB: Involvement in Synaptic Plasticity and

Memory Formation. E-Book: Bentham.

Professor Philip Newsholme

Newsholme P, Gaudel C, Krause M (2012) 'Mitochondria and diabetes. An intriguing

pathogenetic role' In: Roberto Scatena, P Bottoni B Giardina (eds). Advances in

Experimental Medical Biology. New York London: Springer.

Dr Jens Erik Nielsen

Johnston MA, Nielsen JE (2011) 'Constructing and Evaluating Predictive Models for

Protein Biophysical Characteristics' In: Ralph Wheeler (eds). Annual Reports in

Computational Chemistry. Amsterdam: Elsevier.

Professor Dominic Walsh

Teplow DB and Walsh DM (2012) 'Alzheimer's disease and the amyloid beta-protein in

The Molecular Biology of Neurodegenerative Diseases' In: Progress in Molecular

Biology and Translational Science. Elsevier: Academic Press.

Byrne S, Rowland LP, VonsattelJPF, Welzel AT, Walsh DM and Hardiman O (2011)

'Common Themes in the Pathogenesis of Neurodegeneration' In: O. Hardiman and C.

Doherty (eds). Neurodegenerative Disorders. London: Springer.

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Books Edited

Professor Steffen Backert

Oyarzabal OA, Backert S (Ed.). (2012) Microbial Food Safety: an introduction. New York

London: Springer Verlag.

Dr Gerard Cagney

Cagney G, and Emili A (Ed.). (2011) Network Biology: Methods and Applications (Methods

in Molecular Biology). New York London:: Springer.

Dr Chandralal Hewage

Hewage C (Ed.). (2012) EUROMAR 2012. Keynote Dublin: Keynote. Back to Top

Peer Reviewed Journals

Professor Steffen Backert

Hirsch C, Tegtmeyer N, Rohde M, Rowland M, Oyarzabal OA, Backert S. (2012) 'Live

Helicobacter pylori in the root canal of endodontic-infected deciduous teeth'. Journal of

gastroenterology, 47 (8).

Conradi J, Huber S, Gaus K, Mertink F, Gracia SR, Strijowski U, Backert S, Sewald N

(2012) 'Cyclic RGD peptides interfere with binding of the Helicobacter pylori protein

CagL'. Amino Acids, 43 :219-232.

Backert S, Tegtmeyer N (2012) 'Helicobacter pylori CagA tertiary structure reveals

functional insights'. Cell Host and Microbe, 12 (1):3-5.

Smolka A, Backert S (2012) 'How Helicobacter pylori infection controls gastric acid

secretion'. Gastroenterology, 47 (6):609-618.

Conradi J, Tegtmeyer N, Huber, S, Gaus, K, Mertink F, Gracia SR, Strijowski U,

Sewald N, Backert S (2012) 'An RGD Helper Sequence in CagL of Helicobacter pylori

Assists in Interactions with Integrins and Injection of CagA'. Frontiers in Cellular and

Infection Microbiology, 2 (70).

Mueller D, Tegtmeyer N, Brandt S, Yamaoka Y, De Poire E, Sgouras D, Wessler S,

Torres J, Smolka A, Backert S. (2012) 'c-Src and c-Abl kinases control hierarchic

phosphorylation and function of the CagA effector protein in Western and East Asian

Helicobacter pylori strains'. The Journal of clinical investigation, 122 :1553-1566.

Boehm, M, Hoy B, Rohde M, Tegtmeyer N, Baek KT, Oyarzabal OA, Brondsted L,

Wessler S, Backert S (2012) 'Rapid paracellular transmigration of Campylobacter jejuni

across polarized epithelial cells without affecting TER: role of proteolytic-active HtrA

cleaving E-cadherin but not fibronectin'. Gut Pathogens, 4 (1).

O'Croinin T, Backert S. (2012) 'Host epithelial cell invasion by Campylobacter jejuni:

trigger or zipper mechanism?'. Frontiers in Cellular and Infection Microbiology, 2 (25).

Hoy B, Geppert T, Reisen F, Boehm M, Plattner, P, Gadermaier G, Sewald N, Ferreira

F, Briza P, Schneider G, Backert S, Wessler S (2012) 'Distinct roles of HtrA proteases

from different Gram-negative bacteria in cleaving the junctional protein and tumor

suppressor E-cadherin'. Journal of Biological Chemistry, 287 (13):10115-10120.

Golz S, Sharbati S, Backert S, Alter T (2012) 'Quorum sensing dependant phenotypes

and their molecular mechanisms in Campylobacterales'. European Journal of

Microbiology and Immunology, 2 :50-60.

Wiedemann T, Hofbaur S, Tegtmeyer N, Huber S, Sewald N, Wessler S, Backert S.,

Rieder G. (2012) 'Helicobacter pylori CagL-dependent induction of gastrin expression

via a novel αvβ5-integrin-integrin linked kinase signalling complex'. Gut, 61 :986-996.

Boehm M, Krause M, Rohde M, Tegtmeyer N, Takahashi S, Oyarzabal OA Backert S

(2011) 'Major host factors in host cell invasion of Campylobacter jejuni: Role of

fibronectin, Integrin Beta1, FAK, Tiam-1, and DOCK180 in activating Rho GTPase

Rac1'. Frontiers in Cellular and Infection Microbiology, 1 (17).

Krause M, Boehm M, Rohde M, Tegtmeyer N, Takahashi S, Buday L, Oyarzabal OA,

Backert S (2011) 'The signaling pathway of Campylobacter jejuni-induced Cdc42

activation: Role of fibronectin, integrin beta1, tyrosine kinases and guanine exchange

factor Vav2'. Cell Communication and Signaling, 9 (32).

Backert S, Clyne M, Tegtmeyer N (2011) 'Molecular mechanisms of gastric epithelial

cell adhesion and injection of CagA by Helicobacter pylori'. Cell Communication and

Signaling, 9 :28-35.

Tegtmeyer N, Backert S (2011) 'Role of Abl and Src family kinases in actin-cytoskeletal

rearrangements induced by the Helicobacter pylori CagA protein'. European Journal of

Cell Biology, 90 (11):880-940.

Backert S and Clyne M (2011) 'Pathogenesis of Helicobacter pylori infection'.

Helicobacter, 16 (Supplement 1):19-25.

Dr Orina Belton

Mooney D, McCarthy C, Belton O (2012) 'Effects of conjugated linoleic acid isomers on

monocyte, macrophage and foam cell phenotype in atherosclerosis'. Prostaglandins &

other lipid mediators, 98 (3-4):56-62.

Reynolds CM, Toomey S, McBride R, McMonagle J, Morine MJ, Belton O, Moloney

AP, Roche HM (2012) 'Divergent effects of a CLA-enriched beef diet on metabolic

health in ApoE(-/-) and ob/ob mice'. Journal of Nutritional Biochemistry, Epub ahead of

print .

Duffy MM, Pindjakova J, Hanley SA, McCarthy C, Weidhofer GA, Sweeney EM,

English K, Shaw G, Murphy JM, Barry FP, Mahon BP, Belton O, Ceredig R, Griffin

MD; (2011) 'Mesenchymal stem cell inhibition of T-helper 17 cell- differentiation is

triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor'. J

IMMUNOL, 41 (10):2840-2851.

Dr Oliver Blacque

Radford R, Slattery C, Jennings P, Blaque O, Pfaller W, Gmuender H, Van Delft J,

Ryan MP, McMorrow T. (2012) 'Carcinogens induce loss of the primary cilium in

human renal proximal tubular epithelial cells independently of effects on the cell cycle'.

American Journal of Physiology-Renal Physiology, 302 (8):905-916.

Kaplan OI, Doroquez DB, Cevik S, Bowie RV, Clarke L, Sanders AAWM, Kida K,

Rappoport JZ, Sengupta P and Blacque OE (2012) 'Endocytosis Genes Facilitate Protein

and Membrane Transport in C. elegans Sensory Cilia'. Current Biology, 22 (6):451-460.

Reynolds AL, Blacque OE, Kennedy BN. (2012) 'The genetics of outer segment

morphogenesis in zebrafish'. Advances in Experimental Medical Biology, 723 :431-441.

Reiter JF, Blacque OE, Leroux MR. (2012) 'The base of the cilium: roles for transition

fibres and the transition zone in ciliary formation, maintenance and

compartmentalization'. Embo Reports, 13 (7):608-618.

Huang L, Szymanska K, Jensen VL, Janecke AR, Innes AM, Davis EE, Frosk P, Li C,

Willer JR, Chodirker BN, Greenberg CR, McLeod DR, Bernier FP, Chudley AE, Muller

T, Shboul M, Logan CV, Loucks CM, Beaulieu CL, Bowie RV, Bell SM, Adkins J,

Zuniga FI, Ross KD, Wang J, Ban MR, Becker C, Nurnberg P, Douglas S, Craft CM,

Akimenko MA, Hegele RA, Ober C, Utermann G, Bolz HJ, Bulman DE, Katsanis N,

Blacque OE, Doherty D, Parboosingh JS, Leroux MR, Johnson CA, Boycott KM.

(2011) 'TMEM237 is mutated in individuals with a Joubert syndrome related disorder

and expands the role of the TMEM family at the ciliary transition zone'. American

Journal of Human Genetics, 89 (6):713-730.

Professor Geraldine Butler

Riccombeni1 A, Vidanes1 G, Proux-Wera E, Wolfe KH, Butler G (2012) 'Sequence and

analysis of the genome of the pathogenic yeast Candida orthopsilosis'. PLoS ONE, 7

(e35750).

Guida A, Lindstaedt C, Maguire SL, Ding C, Higgins DG, Corton NJ, Berriman M,

Butler G; (2011) 'Using RNA-seq to determine the transcriptional landscape and the

hypoxic response of the pathogenic yeast Candida parapsilosis'. BMC Genomics, 12 .

Ding C, Vidanes GM, Maguire SL, Guida A, Synnott JM, Andes DR, Butler G (2011)

'Conserved and Divergent Roles of Bcr1 and CFEM Proteins in Candida parapsilosis

and Candida albicans'. PLoS ONE, 6 .

Dr Patrick Caffrey

Stephens N, Rawlings B, Caffrey P (2012) 'Streptomyces nodosus host strains optimised

for glycosylation engineering'. Bioscience Biotechnology and Biochemistry, 76 (2):384-

387.

Dr Gerard Cagney

Ryan CJ, Roguev A, Patrick K, Xu J, Jahari H, Tong Z, Beltrao P, Shales M, Qu H,

Collins SR, Kliegman JI, Jiang L, Kuo D, Tosti E, Kim HS, Edelmann W, Keogh MC,

Greene D, Tang C, Cunningham P, Shokat KM, Cagney G, Svensson JP, Guthrie C,

Espenshade PJ, Ideker T, Krogan NJ (2012) 'Hierarchical Modularity and the Evolution

of Genetic Interactomes across Species'. Molecular cell, 46 (5):691-704.

Hunkapiller J, Shen Y, Diaz A, Cagney G, McCleary D, Ramalho-Santos M, Krogan N,

Ren B, Song JS, Reiter JF (2012) 'Polycomb-like 3 promotes polycomb repressive

complex 2 binding to CpG islands and embryonic stem cell self-renewal'. PLoS

Genetics, 8 (3).

Jager S, Cimermancic P, Gulbahce N, Johnson JR, McGovern KE, Clarke SC, Shales M,

Mercenne G, Pache L, Li K, Hernandez H, Jang GM, Roth SL, Akiva E, Marlett J,

Stephens M, D'Orso I, Fernandes J, Fahey M, Mahon C, O'Donoghue AJ, Todorovic A,

Morris JH, Maltby DA, Alber T, Cagney G, Bushman FD, Young JA, Chanda SK,

Sundquist WI, Kortemme T, Hernandez RD, Craik CS, Burlingame A, Sali A, Frankel

AD, Krogan NJ (2011) 'Global landscape of HIV-human protein complexes'. Nature,

481 (7381):365-370.

Dr John Crean

O'Donovan HC, Hickey F, Brazil DP, Kavanagh DH, Oliver N, Martin F, Godson C,

Crean J (2012) 'Connective tissue growth factor antagonizes transforming growth factor-

β1/Smad signalling in renal mesangial cells'. Biochem J, 441 :499-510.

Professor Paul Engel

Engel, P.C. (2011) 'A marriage full of surprises: forty-five years living with glutamate

dehydrogenase'. Neurochemistry International, 59 (4):489-494.

Professor William Gallagher

Collins BC, Miller CA, Sposny A, Hewitt P, Wells M, Gallagher WM, Pennington SR

(2012) 'Development of a pharmaceutical hepatotoxicity biomarker panel using a

discovery to targeted proteomics approach'. Molecular & Cellular Proteomics, 11

(8):394-410.

Joyce CW, Murphy IG, Rafferty M, Ryan D, McDermott EW, Gallagher WM (2012)

'Tumor profiling using protein biomarker panels in malignant melanoma: application of

tissue microarrays and beyond'. Expert Review of Proteomics, 9 (9):415-423.

Brennan DJ, O'Connor DP, Laursen H, McGee SF, McCarthy S, Zagozdzon R,

Rexhepaj E, Culhane AC, Martin FM, Duffy MJ, Landberg G, Ryden L, Hewitt SM,

Kuhar MJ, Bernards R, Millikan RC, Crown JP, Jirstrom K, Gallagher WM (2012) 'The

cocaine- and amphetamine-regulated transcript mediates ligand-independent activation

of ERα, and is an independent prognostic factor in node-negative breast cancer'.

Oncogene, 31 (30):3483-3494.

Collins BC, Gallagher WM (2012) 'Focus on cancer proteomics'. Proteomics, 12

(13):2065-2066.

Geiger T, Madden SF, Gallagher WM, Cox J, Mann M (2012) 'Proteomic portrait of

human breast cancer progression identifies novel prognostic markers'. Cancer Research,

72 (9):428-439.

Zagozdzon AM, O'Leary P, Callanan JJ, Crown J, Gallagher WM, Zagozdzon R (2012)

'Generation of a new bioluminescent model for visualisation of mammary tumour

development in transgenic mice'. BMC Cancer, 12 (209).

Kulbe H, Chakravarty P, Leinster DA, Charles KA, Kwong J, Thompson RG, Coward

JI, Schioppa T, Robinson SC, Gallagher WM, Galletta L; Australian Ovarian Cancer

Study Group, Salako MA, Smyth JF, Hagemann T, Brennan DJ, Bowtell DD, Balkwill

FR (2012) 'A dynamic inflammatory cytokine network in the human ovarian cancer

microenvironment'. Cancer research, 72 (1):66-75.

O'Connor, AE McGee MM, Likar Y, Ponomarev V, Callanan JJ, O'Shea DF, Byrne AT,

Gallagher WM (2012) 'Mechanism of Cell Death Mediated by a BF2-Chelated

Tetraarylazadipyrromethene Photodynamic Therapeutic'. International Journal of

Cancer, 130 (3):705-715.

Vader P, van der Meel R, Symons MH, Fens MH, Pieters E, Wilschut KJ, Storm G,

Jarzabek M, Gallagher WM, Schiffelers RM, Byrne AT (2011) 'Examining the role of

Rac1 in tumor angiogenesis and growth: a clinically relevant RNAi-mediated approach'.

Angiogenesis, 14 (4):457-466.

Power KA, Grad S, Rutges JP, Creemers LB, van Rijen MH, O'Gaora P, Wall JG, Alini

M, Pandit A, Gallagher WM (2011) 'Identification of cell surface-specific markers to

target human nucleus pulposus cells: expression of carbonic anhydrase XII varies with

age and degeneration'. Arthritis Rheumatology, 63 (12):3876-3886.

Maher SG, McDowell DT, Collins BC, Muldoon C, Gallagher WM, Reynolds JV

(2011) 'Serum proteomic profiling reveals that pretreatment complement protein levels

are predictive of esophageal cancer patient response to neoadjuvant chemoradiation'.

Annals of Surgery, 254 (5):809-816.

O'Donovan N, Byrne AT, O'Connor A E, McGee S, Gallagher W M, and Crown J

(2011) 'Synergistic interaction between trastuzumab and EGFR/HER-2 tyrosine kinase

inhibitors in HER-2 positive breast cancer cells'. Investigational New Drugs, 29 (5):752-

759.

O'Neill AJ, Prencipe M, Dowling C, Fan Y, Mulrane L, Gallagher WM, O'Connor D,

O'Connor R, Devery A, Corcoran C, Rani S, O'Driscoll L, Fitzpatrick JM, Watson RW

(2011) 'Characterisation and manipulation of docetaxel resistant prostate cancer cell

lines'. MOL CANCER, 10 (126).

Sernbo S, Gustavsson E, Brennan DJ, Gallagher WM, Rexhepaj E, Rydnert F, Jirstrom

K, Borrebaeck CA, Ek S (2011) 'The tumour suppressor SOX11 is associated with

improved survival among high grade epithelial ovarian cancers and is regulated by

reversible promoter methylation'. BMC Cancer, 11 (405).

Zagozdzon R, Gallagher WM, Crown, J (2011) 'Truncated HER2: implications for

HER2-targeted therapeutics'. Drug Discovery Today, 16 (17-18):812-816.

Hams E, Saunders SP, Cummins EP, O'Connor A, Tambuwala MT, Gallagher WM,

Byrne A, Campos-Torres A, Moynagh PM, Jobin C, Taylor CT, Fallon PG; (2011) 'The

hydroxylase inhibitor dimethyloxallyl glycine attenuates endotoxic shock via alternative

activation of macrophages and IL-10 production by B1 cells'. Shock, 36 (3):295-302.

Coward J, Kulbe H, Chakravarty P, Leader D A, Vassileva V, Leinster D A, Thompson

R, Schioppa T, Nemeth J A, Vermeulin J, Singh N, Avril N E, Cummings J, Rexhepaj

E, Jirstrom K, Gallagher W M, Brennan D J, McNeish I A, Balkwill F R (2011)

'Interleukin-6 as a therapeutic target in human ovarian cancer'. Clinical Cancer

Research, 17 (18):6083-6096.

Dr Carmel Hensey

O'Shea LC, Mehta J, Lonergan P, Hensey C, Fair T (2012) 'Developmental competence

in oocytes and cumulus cells: candidate genes and networks'. Systems Biology in

Reproductive Medicine, 58 (2):88-101.

Sapetto-Rebow B, McLoughlin SC, O'Shea LC, O'Leary O, Willer JR, Alvarez Y,

Collery R, O'Sullivan J, Van Eeden F, Hensey C, Kennedy BN. (2011) 'Maternal

topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of

zebrafish top2a-/- mutants'. BMC Developmental Biology, 11 (71).

Sapetto-Rebow B, McLoughlin SC, O'Shea LC, O'Leary O, Willer JR, Alvarez Y,

Collery R, O'Sullivan J, Van Eeden F, Hensey C, Kennedy BN. (2011) 'Maternal

topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of

zebrafish top2a-/- mutants'. BMC Developmental Biology, 11 .

Dr Chandralal Hewage

Elsawy MA, Hewage C, Walker B (2012) 'Racemisation of N-Fmoc phenylglycine

under mild microwave-SPPS and conventional stepwise SPPS conditions: attempts to

develop strategies for overcoming this'. Journal of peptide science : an official

publication of the European Peptide Society, 18 (5):302-311.

Dr BreandᮠKennedy

Fichtnera I, Cinatl jr. J, Michaelis M, Sanders LC, Hilger R, Kennedy BN, Reynolds

AL, Hackenberg F, Lally G, Quinn SJ, McRae I and Tacke M (2012) 'In Vitro and In

Vivo Investigations into the Carbene Silver Acetate'. Letters in Drug Design &

Discovery .

Reynolds AL, Blacque OE, Kennedy BN. (2012) 'The genetics of outer segment

morphogenesis in zebrafish'. Advances in Experimental Medical Biology, 723 :431-441.

Casey J, Kawaguchi R, Morrissey M, Sun H, McGettigan P, Nielsen JE, Conroy J,

Regan R, Kenny E, Cormican P, Morris DW, Tormey P, Ni Chroinin M, Kennedy BN,

Lynch S, Green A, Ennis S.; (2011) 'First implication of STRA6 mutations in isolated

anophthalmia, microphthalmia, and coloboma: A new dimension to the STRA6

phenotype'. Human Mutation, 32 (12):1417-1426.

Sapetto-Rebow B, McLoughlin SC, O'Shea LC, O'Leary O, Willer JR, Alvarez Y,

Collery R, O'Sullivan J, Van Eeden F, Hensey C, Kennedy BN. (2011) 'Maternal

topoisomerase II alpha, not topoisomerase II beta, enables embryonic development of

zebrafish top2a-/- mutants'. BMC Developmental Biology, 11 .

Professor Therese Kinsella

Reid HM, Turner EC, Mulvaney EP, Hyland PB, McLean C, Kinsella BT. (2012)

'Interaction of the human prostacyclin receptor and the NHERF4 family member

intestinal and kidney enriched PDZ protein (IKEPP)'. Biochima Et Biophysica Acta -

Molecular Cell Research, 1823 (10):1998-2012.

Keating GL, Turner EC, Kinsella BT. (2012) 'Regulation of the human prostacyclin

receptor gene in megakaryocytes: Major roles for C/EBPδ and PU.1'. Biochimica et

biophysica acta, 1819 :428-445.

Dr Patricia Maguire

Steele BM, Harper MT, Smolenski AP, Alkazemi A, Poole AW, Fitzgerald DJ, Maguire

PB (2012) 'WNT-3a modulates platelet function by regulating small GTPase activity'.

FEBS Letters, 586 (16):2267-2276.

Professor Jonathan Malthouse

Petrillo T, O'Donohoe CA, Howe N, Malthouse JPG (2012) 'Importance of tetrahedral

intermediate formation in the catalytic mechanism of the serine proteases chymotrypsin

and subtilisin'. Biochemistry, 51 (31):6164-6170.

Ceruso M, Howe N, Malthouse JP; (2011) 'Mechanism of the binding of Z-L-tryptophan

and Z-L-phenylalanine to thermolysin and stromelysin-1 in aqueous solutions'.

Biochimica et biophysica acta, 1824 (2):303-310.

Dr Gethin McBean

McBean G J (2012) 'The transsulfuration pathway: a source of cysteine for glutathione

in astrocytes'. Amino Acids, 42 :199-205.

Dr Margaret McGee

Bannon JH, O'Donovan DS, Kennelly SM, Mc Gee MM. (2012) 'The peptidyl prolyl

isomerase cyclophilin A localizes at the centrosome and the midbody and is required for

cytokinesis'. Cell cycle (Georgetown, Tex.), 11 (7):1340-1353.

O'Connor, AE McGee MM, Likar Y, Ponomarev V, Callanan JJ, O'Shea DF, Byrne AT,

Gallagher WM (2012) 'Mechanism of Cell Death Mediated by a BF2-Chelated

Tetraarylazadipyrromethene Photodynamic Therapeutic'. International Journal of

Cancer, 130 (3):705-715.

Mac Fhearraigh S, Mc Gee MM (2011) 'Cyclin B1 interacts with the BH3-only protein

Bim and mediates its phosphorylation by Cdk1 during mitosis'. Cell cycle (Georgetown,

Tex.), 10 (22):3886-3896.

Dr Hilary McMahon

McMahon HEM (2012) 'Prion processing: a double-edged sword?'. Biochemical Society

Transactions, 40 (4):735-738.

Dr Tara McMorrow

Jennings P, Weiland C, Limonciel A, Bloch KM, Radford R, Aschauer L, McMorrow T,

Wilmes A, Pfaller W, Ahr HJ, Slattery C, Lock EA, Ryan MP, Ellinger-Ziegelbauer H.

(2012) 'Transcriptomic alterations induced by Ochratoxin A in rat and human renal

proximal tubular in vitro models and comparison to a rat in vivo model'. Archives of

Toxicology, 86 (4):571-589.

Radford R, Slattery C, Jennings P, Blaque O, Pfaller W, Gmuender H, Van Delft J,

Ryan MP, McMorrow T. (2012) 'Carcinogens induce loss of the primary cilium in

human renal proximal tubular epithelial cells independently of effects on the cell cycle'.

American Journal of Physiology-Renal Physiology, 302 (8):905-916.

Cassidy H, Radford R, Slyne J, O'Connell S, Slattery C, Ryan MP, McMorrow T (2012)

'The role of MAPK in drug-induced kidney injury'. Journal of Signal Transduction,

2012 .

O'Connell S, Tuite N, Slattery C, Ryan MP, McMorrow T. (2012) 'Cyclosporine A-

induced oxidative stress in human renal mesangial cells: a role for ERK 1/2 MAPK

signaling'. Toxicological sciences : an official journal of the Society of Toxicology, 126

(1):101-113.

Martin-Martin N, Dan Q, Amoozadeh Y, Waheed F, McMorrow T, Ryan MP, Szaszi K.

(2012) 'RhoA and Rho kinase mediate cyclosporine A and sirolimus-induced barrier

tightening in renal proximal tubular cells'. International Journal of Biochemistry & Cell

Biology, 44 (1):178-188.

O'Connell S, Slattery C, Ryan MP, McMorrow T. (2012) 'Sirolimus enhances

cyclosporine a-induced cytotoxicity in human renal glomerular mesangial cells'. Journal

of transplantation, 2012 .

Martin-Martin N, Slattery C, McMorrow T, Ryan MP. (2011) 'TGF-β1 mediates

sirolimus and cyclosporine A-induced alteration of barrier function in renal epithelial

cells via a noncanonical ERK1/2 signaling pathway'. American Journal of Physiology-

Renal Physiology, 301 (6):1281-1292.

Ellis JK, Athersuch TJ, Cavill R, Radford R, Slattery C, McMorrow T, Ryan MP,

Ebbels TMD, Keun H (2011) 'Metabolic Response to Low Level Toxicant Exposure in a

Novel Renal Tubule'. Molecular BioSystems, 7 (1):247-257.

Professor Wim Meijer

Garcia MS, Carvalho D, Zlydareva O, Muldoon C, Masterson BF, O'Grady MJ,

Meijer,WG, O'Sullivan JJ, O'Hare GMP (2012) 'An agent-based wireless sensor network

for water quality data collection'. Lecture Notes in Computer Science, 7656 .

Dr Cormac Declan Murphy

Murphy CD and Sandford G (2012) 'Fluorinated drug metabolism in microorganisms'.

Chimica Oggi-Chemistry Today, 30 (3):16-19.

Murphy C (2012) 'The Microbial Cell Factory'. Organic and Biomolecular Chemistry,

10 (10):1949-1957.

Lestini, E; Robertson, K; Murphy, CD; Paradisi, F (2012) 'An alternative mild route to

the synthesis of 4-methylenecyclohex-2-enone, a key moiety of the anticancer

compounds ottelione A and B'. Synthetic Communications, 42 :1864-1876.

Bright T, Clark B, O'Brien E, and Murphy CD (2011) 'Bacterial production of

hydroxylated and amidated metabolites of flurbiprofen'. Journal of Molecular Catalysis

B-Enzymatic, 72 :116-121.

Clark, B.R., O'Connor, S., Fox, D., Leroy, J and Murphy, C.D.; (2011) 'Production of

anticancer polyenes through precursor-directed biosynthesis'. Organic and Biomolecular

Chemistry, 9 (18):6306-6311.

Dr Keith Murphy

Scully D, Fedriani R, Desouza IE, Murphy KJ, Regan CM (2012) 'Regional dissociation

of paradigm-specific synapse remodeling during memory consolidation in the adult rat

dentate gyrus'. Neuroscience, 209 :74-83.

Monopoli MP, Raghnaill MN, Loscher JS, O'Sullivan NC, Pangalos MN, Ring RH, von

Schack D, Dunn MJ, Regan CM, Pennington S, Murphy KJ; (2011) 'Temporal

proteomic profile of memory consolidation in the rat hippocampal dentate gyrus'.

Proteomics, 11 (21):4189-4201.

Professor Philip Newsholme

Bortolon JR, Silva Junior AJ, Murata GM, Newsholme P, Curi R, Pithon-Curi TC,

Hatanaka E (2012) 'Persistence of inflammatory response to intense exercise in diabetic

rats'. Experimental Diabetes Research, 2012 (213986).

da Silva Krause M, Bittencourt A, Homem de Bittencourt PI Jr, McClenaghan NH, Flatt

PR, Murphy C, Newsholme P (2012) 'Physiological concentrations of interleukin-6

directly promote insulin secretion, signal transduction, nitric oxide release, and redox

status in a clonal pancreatic β-cell line and mouse islets'. Journal of Endocrinology, 214

(3):301-311.

Krause M, Rodrigues-Krause J, O'Hagan C, De Vito G, Boreham C, Susta D,

Newsholme P, Murphy C (2012) 'Differential nitric oxide levels in the blood and

skeletal muscle of type 2 diabetic subjects may be consequence of adiposity: a

preliminary study'. Metabolism, Epub June 2012 .

Rodrigues-Krause J, Krause M, O'Hagan C, De Vito G, Boreham C, Murphy C,

Newsholme P, Colleran G (2012) 'Divergence of intracellular and extracellular HSP72

in type 2 diabetes: does fat matter?'. Cell Stress and Chaperones, 17 (3):293-302.

Krause MS, McClenaghan NH, Flatt PR, de Bittencourt PI, Murphy C, Newsholme P

(2011) 'L-arginine is essential for pancreatic β-cell functional integrity, metabolism and

defence from inflammatory challenge'. Journal of Endocrinology, 211 (1):87-97.

Dr Jens Erik Nielsen

Farrell D, Webb H, Johnston MA, Poulsen TA, O'Meara F, Christensen LLH, Beier L,

Borchert TV, Nielsen JE (2012) 'Towards fast determination of protein stability maps:

experimental and theoretical analysis of mutants of a Nocardiopsis prasina serine

protease'. Biochemistry, 51 (26):5339-5347.

Bradley J, O'Meara F, Farrell D, Nielsen JE (2012) 'Highly Perturbed pK< sub> a

Values in the Unfolded State of Hen Egg White Lysozyme'. Biophysical Journal, 102

(7):1636-1645.

Johnston MA, Farrell D, Nielsen JE (2012) 'A collaborative environment for developing

and validating predictive tools for protein biophysical characteristics'. Journal of

Computer-aided Molecular Design, 26 (4):387-396.

Bjarnadottir U, Nielsen JE (2012) 'Predicting the open conformations of protein kinases

using molecular dynamics simulations'. BIOPOLYMERS, 97 (1):65-72.

Casey J, Kawaguchi R, Morrissey M, Sun H, McGettigan P, Nielsen JE, Conroy J,

Regan R, Kenny E, Cormican P, Morris DW, Tormey P, Ni Chroinin M, Kennedy BN,

Lynch S, Green A, Ennis S.; (2011) 'First implication of STRA6 mutations in isolated

anophthalmia, microphthalmia, and coloboma: A new dimension to the STRA6

phenotype'. Human Mutation, 32 (12):1417-1426.

Carstensen T, Farrell D, Huang Y, Baker NA, Nielsen JE (2011) 'On the development of

protein pKa calculation algorithms'. Proteins: Structure, Function, and Bioinformatics,

79 (12):3287-3298.

Nielsen JE, Gunner MR, Garcia‐Moreno E (2011) 'The pKa Cooperative: A

collaborative effort to advance structure‐based calculations of pKa values and

electrostatic effects in proteins. Proteins: Structure, Function, and Bioinformatics'.

Proteins: Structure, Function, and Bioinformatics, 79 (12):3249-3259.

McIntosh LP, Naito D, Baturin SJ, Okon M, Joshi MD, Nielsen JE (2011) 'Dissecting

electrostatic interactions in Bacillus circulans xylanase through NMR-monitored pH

titrations'. Journal of biomolecular NMR, 51 (1):5-19.

Dr John O'Connor

OConnor JJ, Lowry JP (2012) 'A comparison of the effects of the dopamine partial

agonists aripiprazole and 3-PPP with quinpirole on stimulated dopamine release in the

rat striatum: studies using fast cyclic voltammetry'. European Journal of Pharmacology,

686 :60-65.

Dr Kevin O'Connor

Narancic T, Kenny S, Lidija D, Vasiljevic B, O'Connor KE, Nikodinovic-Runic J (2012)

'Medium chain length polyhydroxyalkanoate production by newly isolated Pseudomonas

sp. TN301 from a wide range of poly- and monoaromatic hydrocarbons'. Journal of

Applied Microbiology, 113 :508-520.

Kenny ST, Nikodinovic Runic J, Kaminsky W, Woods T, Babu RP, and O'Connor KE.

(2012) 'Development of a bioprocess to convert PET derived terephthalic acid and

biodiesel derived glycerol to medium chain length polyhydroxyalkanoate'. Applied

Microbiology and Biotechnology, 95 (3):623-633.

Narancic T, Nikodinovic J, Kenny S, Vasiljevic B and K O'Connor. (2012) 'Metabolic

versatility of Gram-positive microbial isolates from contaminated river sediments'.

Journal of Hazardous Materials, 215-216 :243-251.

Nikodinovic-Runic J, Coulombel L, Francuski D, Sharma ND, Boyd DR, More

O'Ferrall R and O'Connor KE (2012) 'The oxidation of alkylaryl sulfides and

benzo[b]thiophenes by Escherichia coli cells expressing wild-type and engineered

styrene monooxygenase from Pseudomonas putida CA-3'. Applied Microbiology and

Biotechnology .

Boyd DR, Sharma ND, McMurray B, Haughey SA, Allen CCR,Hamilton JTG,

McRoberts WC,More O'Ferrall RA, Nikodinovic-Runic J, Coulombel LA and O'Connor

KE. (2012) 'Bacterial dioxygenase- and monooxygenase-catalysed sulfoxidation of

benzo[b]thiophenes'. Org Biomol Chem, 10 :782-790.

Dr Jim O'Gara

Stallard CP, McDonnell KA, Onayemi OD, O'Gara JP, Dowling DP (2012) 'Evaluation

of protein adsorption on atmospheric plasma deposited coatings exhibiting

superhydrophilic to superhydrophobic properties'. Biointerphases, 7 :31-39.

Pozzi C, Waters EM, Rudkin JK, Schaeffer CR, Lohan AJ, Tong P, Loftus BJ, Pier GB,

Fey PD, Massey RC and O'Gara JP (2012) 'Methicillin Resistance Alters the Biofilm

Phenotype and Attenuates Virulence in Staphylococcus aureus Device-Associated

Infections'. PLoS Pathogens, 8 (4):e-1002626.

Rudkin JK, Edwards AM, Bowden MG, Brown EL, Pozzi C, Waters E, Chan W,

Williams P, O'Gara J P and Massey RC (2012) 'Methicillin Resistance Reduces the

Virulence of Healthcare-Associated Methicillin-Resistant Staphylococcus aureus by

Interfering With the agr Quorum Sensing System'. Journal of Infectious Diseases, 205

(5):798-806.

Stevens NT, Greene CM, O'Gara JP, Bayston R, Sattar MT, Farrell M and Humphreys H

(2012) 'Ventriculoperitoneal shunt-related infections caused by Staphylococcus

epidermidis: pathogenesis and implications for treatment'. British Journal of

Neurosurgery, Epub ahead of print .

Galvin S, Boyle M, Russell R, Coleman D, Creamer E, O'Gara JP, DFitzgerald-Hughes

D, Humphreys H (2012) 'A practical evaluation of vaporised hydrogen peroxide,

CITROX and ECASOL in the decontamination of an enclosed area'. Journal of Hospital

Infection, 80 (1):67-70.

Professor Ciaran Regan

Scully D, Fedriani R, DeSouza IEJ, Murphy KJ, Regan CM (2012) 'Regional

dissociation of paradigm-specific synapse remodelling during memory consolidation in

the adult rat dentate gyrus'. Neuroscience, 209 :74-83.

Freir DB, Fedriani R, Scully D, Smith IM, Selkoe DJ, Walsh DM, Regan CM (2011)

'Aβ oligomers inhibit synapse remodelling necessary for memory consolidation'.

Neurobiology of Aging, 32 (12):2211-2218.

Monopoli MP, Nic Raghnaill M, Loscher JS, O'Sullivan NC, Pangalos MN, Ring RH,

Von Schack D, Dunn MJ, Regan CM, Pennington S, Murphy KJ (2011) 'Temporal

proteomic profile of memory consolidation in the rat hippocampal dentate gyrus'.

Proteomics, 11 (21):4189-4200.

Dr Helen Reid

Reid HM, Turner EC, Mulvaney EP, Hyland PB, McLean C, Kinsella BT. (2012)

'Interaction of the human prostacyclin receptor and the NHERF4 family member

intestinal and kidney enriched PDZ protein (IKEPP)'. Biochima Et Biophysica Acta -

Molecular Cell Research, 1823 (10):1998-2012.

Dr Michael Sharkey

Timpson LM, Liliensiek AK, Alsafadi D, Cassidy J, Sharkey MA, Liddell S,Allers T,

Paradisi F (2012) 'A comparison of two novel alcohol dehydrogenase enzymes(ADH1

and ADH2) from the extreme halophile Haloferax volcanii'. Applied Microbiology and

Biotechnology .

Oliveira T, Panjikar S, Carrigan JB, Hamza M, Sharkey MA, Engel PC, Khan AR

(2012) 'Crystal structure of NAD+-dependent Peptoniphilus asaccharolyticus glutamate

dehydrogenase reveals determinants of cofactor specificity'. Journal of Structural

Biology, 177 (2):543-552.

Timpson LM, Alsafadi D, Mac Donnchadha C, Liddell S, Sharkey MA, Paradisi F.

(2012) 'Characterization of alcohol dehydrogenase (ADH12) from Haloarcula

marismortui, an extreme halophile from the Dead Sea'. Extremophiles, 16 (1):57-66.

Sharkey MA, Maher MA, Guyonvarch A, Engel PC (2011) 'Kinetic characterisation of

recombinant Corynebacterium glutamicum NAD+-dependent LDH over-expressed in E.

coli and its rescue of an lldD- phenotype in C. glutamicum: the issue of reversibility re-

examined'. Archives of Microbiology, 193 (10):731-740.

Professor Dominic Walsh

Mc Donald J, Cairns NJ, Taylor-Reinwald L, Holtzman, Walsh DM (2012) 'The levels

of water-soluble and triton-soluble Aβ are increased in Alzheimer's disease brain'. Brain

Research, 1450 :138-147.

Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F1, Kleckers D,

Lopez de Vega JM, Gruning B, Wang Q, Schmidt MR, Lurz R, Roger Anwyl, Schnoegl

S, Fandrich M, Frank RF, Reif B, Gunther S, Walsh DM and Wanker EE (2011) 'An

orcein-related small molecule promotes the conversion of toxic oligomers to non-toxic,

beta-sheet-rich amyloid fibrils'. Nature Chemical Biology, 8 :93-101.

O'Nuallain B, Klyubin I, McDonald JM, Barry A, Dykoski RK, Cleary JP, Gebbink

MFBG, Rowan MJ and Walsh DM (2011) 'A Monoclonal Antibody Against Synthetic

A-beta Dimers Assemblies Neutralizes Brain-Derived Synaptic Plasticity-Disrupting

Abeta'. Journal of neurochemistry, 119 :189-201.

Dr Tadhg ӧCrᮠn

O Croinin T and Backert S. (2012) 'Host Epithelial Cell Invasion by Campylobacter

jejuni: trigger or zipper mechanism?'. Frontiers in Cellular and Infection Microbiology,

2 (25).

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Conference Publications

Dr Orina Belton

McCarthy C, Duffy M, Mooney D, James W, Fitzgerald DJ, Griffin MD, Belton O,

(2012) Il-10 Regulates the Immunoregulatory Response in the Regression of

Atherosclerosis Circulation Research,

McCarthy C, Mooney D, de Gaetano M, James W, Fitzgerald DJ, Belton O (2012)

Activation of the Nuclear Receptor Coactivator PGC-1{alpha} Mediates an

Atheroprotective Effect Circulation Research,

Dr John Crean

Andrews D, Browne J, O'Donovan H, Faherty N, Oliver N, Wallace D, O'Brien C and

Crean J. (2012) Integrated signalling between CTGF and TGFβ2 leads to divergent

activation of canonical and non-canonical pathways controlling EMT in ARPE-19 cells:

Implications for the pathogenesis of proliferative vitreoretinopathy ARVO,

Faherty N, Curran SP, O'Donovan H, Martin F, Godson C, Brazil DP, and Crean J.

(2011) CCN2/CTGF increases expression of miR-302 microRNAs, which target the

TGFβ type II receptor with implications for nephropathic cell phenotypes American

Society of Nephrology,

Dr Tara McMorrow

Cassidy H, Slyne J, Johnston O, Brennan L, O'Riordan A, Conlon P, Ryan MP,

McMorrow T (2011) Metabolomic Profiling Of Chronic Allograft Nephropathy (CAN)

Resulting From Immunosuppressant Therapies In Post Renal Transplantation Patients

HUPO 10th World Congress, Geneva, Switzerland,

Dr John O'Connor

Mukandala GD, O'Connor, JJ (2012) TNF-α synthesis inhibition post hypoxia impairs

long-term potentiation in the dentate gyrus in vitro FENS Barcelona,

Corcoran AE, Harney SC, O'Connor JJ (2012) Prolyl hydroxylase inhibition impairs

long-term potentiation in the rat hippocampus FENS Barcelona,

Wall AM, O'Connor JJ (2012) Tumour necrosis factor alpha does not impair long term

potentiation following an acute hypoxic insult FENS Barcelona,

Fanning RA, McMorrow JP, Campion DP, Carey MF, O'Connor JJ (2012) Opioid

mediated activity in human term non-laboring myometrium Royal Academy of Medicine

in Ireland, Biomedical Sciences Section, Galway,

Fanning RA, Duffy N, Leonard M, Ahmed JJ, O'Connor JJ (2012) The oxytocic effect

of ergometrine on human myomterium in vitro does not involve 5-HT2 receptor

activation Royal Academy of Medicine in Ireland, Biomedical Sciences Section,

Fanning RA, Duffy N, Leonard M, Ahmed JJ, O'Connor JJ (2012) An investigation into

the effects of ergometrine on human myomterium in vitro International Society of

Obstetric Anaesthesia,

O'Connor JJ, Dalton M, Cavanni P, Large CH, Lowry JP (2011) A comparison of the

effects of the dopamine partial agonists aripiprazole and (-)- 3-PPP with quinpirole on

stimulated dopamine release in the rat striatum: studies using fast cyclic voltammetry in

vitro Neuroscience Ireland Annual meeting NUI Maynooth, Irish Journal of Medical

Science,

Corcoran AE, O'Connor JJ (2011) Dimethyloxalyl Glycine Decreases Synaptic

Signalling and Impairs Long Term Potentiation in the Rat Hippocampus Neuroscience

Ireland Annual meeting NUI Maynooth, Irish Journal of Medical Science,

Wall AM, O'Connor JJ (2011) Acute hypoxia impairs the recovery of synaptic

transmission in the rat dentate gyrus and potentiates long-term potentiation in the

presence of tumour necrosis factor-alpha and picrotoxin Neuroscience Ireland Annual

meeting NUI Maynooth, Irish Journal of Medical Science,

Corcoran AE, O'Connor JJ (2011) Acute effects of hypoxia and prolyl hydroxylase

inhibition on synaptic plasticity in the rat hippocampus Soc Neuroscience,

Dr Kevin O'Connor

Guzik M, Duane G, Kenny S, Casey E, O'Connor K (2011) Mathematical modelling of

the bioprocess for PHA production European Congress of Applied Biotechnology,

Berlin,

Dr Tadhg ӧCrᮠn

Shortt C, Scanlan E, Bourke, B and O Croinin T (2012) Alteration of DNA Topology

leads to changes in Flagella gene expression in Campylobacter jejuni American Society

of Microbiology, General Meeting,

Scanlan E, Shortt C, Bourke B, and O Croinin T (2012) DNA Supercoiling in

Campylobacter jejuni: A Potential Trigger for Invasion American Society of

Microbiology, General Meeting,

Shortt C, Scanlan E, Bourke B and O Croinin T (2012) DNA topology influences

motility and chemotaxis in the enteric pathogen, Campylobacter jejuni SGM General

Meeting,

Scanlan E, Shortt C, Bourke B and O Croinin T (2012) A link between DNA topology

and the invasive phenotype of Campylobacter jejuni SGM General Meeting,

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