Upload File

repository of the max delbrück center for molecular medicine...

  • Home
  • Documents
  • Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
40
Repository of the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association https://edoc.mdc-berlin.de/16775 Allosteric modulators targeting CNS muscarinic receptors Bock, A., Schrage, R., Mohr, K. This is the final version of the accepted manuscript as first published by Elsevier. The original article has been published in final edited form in: Neuropharmacology 2017 JUL 01 ; 136(Part C): 427-437 2017 SEP 18 (first published online: final publication) doi: 10.1016/j.neuropharm.2017.09.024 Publisher: Elsevier Copyright © 2017 Elsevier. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by- nc-nd/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA.

Upload: others

Post on 24-Jan-2021

6 views

Category:

Documents


0 download

Report

TRANSCRIPT

Page 1: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular

Repository of the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz Association

https://edoc.mdc-berlin.de/16775

Allosteric modulators targeting CNS muscarinic receptors

Bock, A., Schrage, R., Mohr, K.

This is the final version of the accepted manuscript as first published by Elsevier. The original article has been published in final edited form in:

Neuropharmacology 2017 JUL 01 ; 136(Part C): 427-437 2017 SEP 18 (first published online: final publication) doi: 10.1016/j.neuropharm.2017.09.024

Publisher: Elsevier

Copyright © 2017 Elsevier. This manuscript version is made available under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0

International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/ or send a letter to Creative Commons, PO Box 1866, Mountain View, CA 94042, USA.

https://creativecommons.org/licenses/by-nc-nd/4.0/
https://edoc.mdc-berlin.de/16775
https://doi.org/10.1016/j.neuropharm.2017.09.024
https://www.elsevier.com/
https://creativecommons.org/licenses/by-nc-nd/4.0/
https://creativecommons.org/licenses/by-nc-nd/4.0/
Page 2: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 3: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 4: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 5: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 6: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 7: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 8: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 9: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 10: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 11: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 12: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 13: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 14: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 15: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 16: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 17: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 18: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 19: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 20: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 21: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 22: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 23: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 24: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 25: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 26: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 27: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 28: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 29: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 30: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 31: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 32: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 33: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 34: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 35: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 36: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 37: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 38: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 39: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular
Page 40: Repository of the Max Delbrück Center for Molecular Medicine (MDC…edoc.mdc-berlin.de/16775/1/16775oa.pdf · 2018. 12. 13. · Repository of the Max Delbrück Center for Molecular

Repository of the Max Delbrück Center for Molecular ...edoc.mdc-berlin.de/14447/1/14447oa.pdfdark cycle. Animals were housed in a pathogen free facility at the Max-Delbrück-Center

Repository of the Max Delbrück Center for Molecular ...edoc.mdc-berlin.de/14402/1/14402oa.pdf · N. Muller, PhD 5,6; Friedrich C. Luft, MD 5; Jens Titze, MD 1,7; and Thoralf Niendorf,

Project Name Documentation · •Databox repository •DataboxCollection repository •DataboxDocumentStructure repository •DataboxStatus repository •Entry repository •Feed

Media Education Research Journal - Lincoln Repositoryeprints.lincoln.ac.uk/16775/7/__ddat01_staffhome_bjones... · 2015-02-24 · Call for papers - MERJ 5.2 The Media Education Research

Efficient CRISPR-mediated mutagenesis in primary … · aMax Delbrück Center for Molecular Medicine, 13125 Berlin, Germany; bCentre d’Immunologie de Marseille-Luminy, Université

Butterfield Estates Homeowners’ Associationbutterfieldestates.com/butterfieldassociation/ruleregs/... · 2018. 3. 12. · 16775 Von Karman Avenue, Suite 1 Professionally Managed

Repository of the Max Delbrück Center for Molecular ...edoc.mdc-berlin.de/13245/1/13245oa.pdf · Repository of the Max Delbrück Center for Molecular Medicine (MDC) in the Helmholtz

Delbrück, Max, Aristotle-totle-totle (art. de 1971)

Delbrück scattering as a High Precision Vacuum Probe

The History of Phage Research2015phage.org/media/Posters/1940s.pdf · The History of Phage Research! Ty Roach & Emma George! PHAGE RECOMBINATION 1946–!HERSHEY!&!DELBRÜCK! • Hershey!and!Delbrück!independently!discovered!that!

Repository of the Max Delbrück Center for Molecular ...edoc.mdc-berlin.de/13605/1/13605oa.pdf · CNS-diff use manifestations ( 8, 25, 31 – 33 ). The serum titer of anti-P has been

Repository of the Max Delbrück Center for Molecular ...edoc.mdc-berlin.de/15950/7/15950oa.pdf · HEMATOPOIESIS AND STEM CELLS Identification of novel regulators of developmental

Debating Cannae- Delbrück Schlieffen and the Great War

Repository of the Max Delbrück Center for Molecular Medicine …edoc.mdc-berlin.de/16566/1/16566oa.pdf · 2018-09-24 · 1 METHODS Issue: CRISPR-Cas systems for genome engineering

Repository of the Max Delbrück Center for Molecular Medicine …edoc.mdc-berlin.de/14306/7/14306oa.pdf · 2017. 5. 2. · Weiss and Daniela Panáková Lantow, Sergei A. Kuznetsov,

URINARY TRACT STRUCTURE AND INFECTION 1medicaltextbooksrevealed.s3.amazonaws.com/files/16775-53.pdf · urinary abnormalities suggest the urinary tract is a source of the sepsis. To

Gene editing: From biblical times to the present Klaus Rajewsky Max-Delbrück-Center for Molecular Medicine, Berlin

Repository BNTU - Repository BNTU

Repository of the Max Delbrück Center for Molecular ...edoc.mdc-berlin.de/15139/1/15139oa.pdf · Olaf Jöhren, Peter Dominiak, L.M. Fredrik Leeb-Lundberg and Michael Bader Acute

2019 Green Footprints Campaign - kinder-meilen.de · Photo: Jan Amos Komenski School, Karposh Photo: Delbrück Photo: Mittelpunktgrundschule, Hungen. A Europe-wide campaign for sustainable

Repository of the Max Delbrück Center for Molecular ...edoc.mdc-berlin.de/14680/1/14680oa.pdf · 2 ABSTRACT : Objective. A hallmark of rheumatoid arthritis (RA) is the chronic pain

Other Business and Biodiversity initiatives Kilian Delbrück Head of Division The Federal Environment Ministry – Germany Brussels, 21/11/2014 Business and

Topological C*-Categoriesetheses.whiterose.ac.uk/16775/1/[OSullivan_D... · C -algebras. For example, the collection of structure preserving homomorphisms between any two C -categories

Fedora Classroom · 2018. 8. 13. · Git repository: Fedora Council Docs Git repository: Quick Docs Git repository: Mentored Projects Git repository: Fedora Modularity Git repository:

Repository of the Max Delbrück Center for Molecular Medicine … · 2020-05-11 · ERK1 as a Therapeutic Target for Dendritic Cell Vaccination against High-Grade Gliomas Min-Chi

Repository of the Max Delbrück Center for Molecular ...edoc.mdc-berlin.de/15318/1/15318oa.pdf · neurodegenerative processes. Surprisingly, genome-wide association studies now implicate

MAX-DELBRÜCK-CENTRUM · Web viewClinical Research Focus Single Cell Approaches for Personalized Medicine Job-code.:xxxx/2020 Department:Berlin Institute for Medical Systems Biology,

Repository of the Max Delbrück Center for Molecular ...edoc.mdc-berlin.de/14714/1/14714oa.pdf · This manuscript was published in final edited form in: Circulation . 2015 MAY 19

Automatically generated PDF from existing images. · 12.08. Paderborn, Körm. Nordsieck Mst. Sandra Schröter-Battran, Godefriedstr. 12, 33129 Delbrück Tel. 05250 9369120 Fax 05250

Repository of the Max Delbrück Center for Molecular Medicine …edoc.mdc-berlin.de/17135/1/17135oa.pdf · 2019. 10. 30. · Repository of the Max Delbrück Center for Molecular Medicine

Recombination Early Experiments: 1947 Alfred Hershey and Max Delbrück 1961 Matthew Meselson and Jean Weigle *Homologous Genetic Recombination *Site Specific

Journals - Max Delbrück Center for Molecular Medicine in the … · 2016-06-28 · Acta Myologica Electronic Holding: 26.2007 - Acta Neurobiologiae Experimentalis Formerly known

RIDE QUALITY AND INTERNATIONAL STANDARD N76-16775 EVALUATION OF HUMAN · PDF file · 2016-06-07RIDE QUALITY AND INTERNATIONAL STANDARD ISO 2631 ... requirements, to review briefly

Insights - MemberClicks 2018_final.pdfIndustry: Administration Contact: Cherie Moser. PriceKubecka. 16775 Addison Rd, Suite 500 Addison, TX 75001 Industry: Accounting Services Contact:

Mutations of Bacteria From Virus Sensitivity to Virus Resistance S. E. Luria and M. Delbrück