research advocacy training - sept 2016
TRANSCRIPT
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CANCER BIOLOGYResearch Advocacy Training and Support Program
Our webinar will begin shortly.
WELCOME!
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• Speaker(s): Dan A. Dixon, PhD and Nancy Roach, Fight CRC Founder and Cancer Advocate
• Archived Webinars: FightColorectalCancer.org/Webinars
• AFTER THE WEBINAR: Expect an email with links to the material & a survey. If you fill it out, we’ll send you a Blue Star pin.
• Ask a question in the panel on the RIGHT SIDE of your screen
• Follow along via Twitter – use the hashtag #CRCWebinar
Today’s Webinar:
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What is a RESEARCH ADVOCATE? A research advocate brings the patient viewpoint to the research process and communicates a collective patient perspective.
Fight CRC’s Research Advocacy Training and Support (RATS) Program:
Goal: to improve the ability of research advocates to effectively participate in the research process. This is done by hosting person meetings, online trainings, and webinars, in addition to ongoing support.
Brought to you by RATS:
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Resources:
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Disclaimer:
The information and services provided by Fight Colorectal Cancer are for general informational purposes only. The information and services are not intended to be substitutes for professional medical advice, diagnoses or treatment.
If you are ill, or suspect that you are ill, see a doctor immediately. In an emergency, call 911 or go to the nearest emergency room.
Fight Colorectal Cancer never recommends or endorses any specific physicians, products or treatments for any condition.
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Goals for today
– Gain a basic understanding of normal cell biology and what makes cancer happen.
– Get a feel for some of the language and process of basic research.
– Understand some of the questions that need to be answered in order to move the field forward.
– Feel more comfortable with being overwhelmed by scientific language.
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DoD grant
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Dan Dixon & Nancy Roach
Fight CRC Founder & Chair of the BoardCo-Leader: Cancer Prevention & SurvivorshipUniv. of Kansas NCI-Designated Cancer Center
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Cell Structure
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Cells, genes and signaling pathways
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Cell Communication
http://sciencedoing.blogspot.com/2012/10/cell-‐receptors-‐2012.html
Cell membrane
Signaling pathway
Signal transduction
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Review!• We are made of cells.• Genes control what cells do.• Signaling pathways inside of cells tell the genes what to do.
• Signal transduction is the process of cells talking and listening to each other.
• Ligands are the molecules that float around outside cells (signal transduction!).
• Receptors are the proteins that stick outside of cells and grab the ligands (signaling pathways!).
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Normal colon stem cells
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CancerStem Cell
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Normal Colon(colonscopy)
Colorectal Cancer (CRC)
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TIME!
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Review!
• Our bodies are very complicated collections of cells that interact in a controlled, balanced way.
• Cell growth is usually controlled by genes and the signals they send out BUT…
• If mutations of key genes occur, cell growth can go out of control and lead to cancer.
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VOCABULARY!
• Oncogenes• Tumor suppressor genes–Apoptosis
• DNA repair genes
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Growth Control Signaling Pathway
Note: Growth Factors are LIGANDS
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Normal Stage 0 Stage 1 – 2 Stage 2 – 3 Stage 4
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Mutations in Colorectal Cancer
Oncogenes and Tumor Promoters Tumor Suppressors
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Review
• Oncogenes: accelerator on.• Tumor suppressor genes: brakes off.• DNA repair genes: sensors and mechanic don’t work.• Cancer involves multiple mutations over time in order to overcome our natural defenses.
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Why Cancer Biology Is Important
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Question & Answer:
SNAP A #STRONGARMSELFIEBayer HealthCare will donate $1 for every photo posted (up to $25,000).
Flex a “strong arm” & post it to Twitter or Instagram! (Use the hashtag!)