research and technology transfer at the bio/nano/electronic interface applied biotechnology...
TRANSCRIPT
RESEARCH AND TECHNOLOGY
TRANSFER AT THE
BIO/NANO/ELECTRONIC INTERFACE
Applied Biotechnology Innovation Centre
Ioanis KatakisOctoner 25, 2004
Tarragona
Applied Biotechnology Innovation Centre
WHO ARE WE?
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Students
PhD
Technicians
BBCAT
Evolution
of membership
Applied Biotechnology Innovation Centre
HOW WE FINANCE OUR WORK?
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private
public
BBCAT
Applied Biotechnology Innovation Centre
HOW WE WORK?
Knowledge Creation• Biosensors• Bioelectronics• Nanotechnology• Microsystems• (Photo)catalysis• Biotechnology
Technology Transfer• Clinical & veterinary diagnostics• Biomedical applications• Food & Agriculture• Pharmaceutical & Fine Chemicals• Chemical Industry• Renewable energies
Innovation• Spin off companies• New educational/vocational
models
Applied Biotechnology Innovation Centre
OUR SECOND RESEARCH PLAN
MICROSYSTEMSMICROSYSTEMS
Enzyme (NAD) BIOELECTRONICSBIOELECTRONICS
NANOTECHNOLOGYNANOTECHNOLOGY
BIOSENSORSBIOSENSORS
NEW AREASNEW AREAS
APPLIED RESEARCHAPPLIED RESEARCH
Immunosensors
DNA Biofuel cells Neuron chip
Directed deposition Nanocatalysts
Screen printed Microreactors Aptamers
Bioreactors
Solar Cells
Making immuno strips and systems
Applied Biotechnology Innovation Centre
FROM SUB MOLECULAR TO MACRO
GENESGENES
PROTEINSPROTEINS
CELLSCELLS
TISSUESTISSUES
ORGANSORGANS
ORGANISMSORGANISMS
ECOSYSTEMSECOSYSTEMS
NANOTECHNOLOGYNANOTECHNOLOGY
BIOSENSORSBIOSENSORS
BIOELECTRONICSBIOELECTRONICS
TISSUE ENGINEERINGTISSUE ENGINEERING
IN VITRO SYSTEMSIN VITRO SYSTEMS
MICROSYSTEMSMICROSYSTEMS
MULTI MICRO BIOREACTORSMULTI MICRO BIOREACTORS
ENVIRONMENTAL BIOTECHNOLOGYENVIRONMENTAL BIOTECHNOLOGY
MA
TE
RIA
LS
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AN
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ND
CH
EM
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Applied Biotechnology Innovation Centre
SOME RESEARCH LINES (1/4)
MODULE 1
--
MODULE 2
++ + MODULE 3
-- -
MODULE 4
Os
Os Os+ +
MODULE 5
MODULE 6...
-
-+
+
+
Os
Os
Os
+
+-
-
-
SELF ASSEMBLY FOR THE ULTIMATE (BIO)CHEMICAL CATALYTIC FLEXIBILITY
• Narváez et al. Biosens Bioelectr 15:43-52 (2000)
• Narváez et al. J Electroanal Chem 430:227-33 (1997)
Applied Biotechnology Innovation Centre
SOME RESEARCH LINES (2/4)
SUPRAMOLECULAR ARCHITECTURES FOR COMPLEX BIOSENSING, AMPLIFICATION, AND
CATALYSIS TASKS
• Popescu et al. J Electroanal Chem 464:208-14 (1999) (+2 in preparation)
• V. Pavlov Thesis (2005) on biosensors, K. Horton DEA (2003) liposomes
Sonicate, extrude
Applied Biotechnology Innovation Centre
SOME RESEARCH LINES (3/4)
• Campàs & Katakis Int J Env Anal (in press), PCT&US pat. Appl (2002)
• M. Campàs PhD Thesis (2003), S. Dondapati DEA Thesis (2004)
gold colloidoligonucleotide
colloidal gold-oligonucleotideselective deposition
deposition
conjugation
NANOCOLLOID SYNTHESIS AND MODIFICATION FOR NANOPATTERNING AND ARTIFICIAL
INTELLIGENCE
Applied Biotechnology Innovation Centre
SOME RESEARCH LINES (4/4)
Os+Os+
Os+Os+
Os+Os+
Os+Os+
Os+Os+
Os+Os+
- - --- -
+ + +++ +- - --
- - }N1
+ + +++ +
+ + +++ + }N2
- - --- -
Glucose oxidase produces H2O2
Peroxidase uses H2O2 and consumes electrons at E2
Glucose oxidase produces electrons at E1
e-
e-
• P. Pescador DEA thesis (2004) Biofuel cells
TOWARDS THE ULTIMATE NANOMACHINE(?): SELF POWERED, SELF PROPELLED, SELF PROPAGATING
Applied Biotechnology Innovation Centre
BBG/DINAMIC MOST VALUABLE RESOURCE
• Magda Constanti (Lector, Microbiology)
• Teresa Hechevarria (Torres Quevedo, Chemical
Engineering)
• Ioanis Katakis (Associate professor, Chemical
Engineering)
• Petros Lenas (Ramon y Cajal, Tissue Engineering)
• Przemyslaw Los (Visiting Professor, Physical
Chemistry)
•Josep Ma Montornés (Post doctoral fellow, Org.
Synthesis)
• Susana Rodríguez (Ramon y Cajal, Bioprocess
Engineering)
• Jose Luis Toca-Herrera (Ramon y Cajal,
Nanotechnology)
SENIOR MEMBERS AND PROJECT MANAGERS
Applied Biotechnology Innovation Centre
BBG/DINAMIC MOST VALUABLE RESOURCE
PERMANENT TECHNICIANS AND SUPPORT
• Barbara Vastenavond (Administration)• Lea Gragert (Administration and accounting)• Mònica Mir (Technician, Electrochemistry)• Joaquim Solana (Marketing, Project support)• Diego Bejarano (Technician, Chemical & Process Engineering)• Marta Jimenez (Technician, microbiology)• MireiaMassanell (Technician, Immunology)• Cristina Sanz (Technician, Analytical techniques)• Xavier Roch (IT Technician)
Applied Biotechnology Innovation Centre
BBG/DINAMIC MOST VALUABLE RESOURCE GRADUATE STUDENTS AND TRAINEES
• Mònica Mir (PhD Student, Bioelectrochemistry)• Srujan Dondapati (PhD Student, Bioelectrochemistry)• Paula Pescador (PhD Student, Molecular biology/fuel cells)• Veronica Saravia (PhD Student, Tissue engineering)• Viviana Duarte (PhD Student, Immunosensors)• Frank Jeyson (PhD Student, Biofuel cells)• Kelly Briceño (PhD Student, Bioelectrochemistry)• Peter Pfeiffer (PhD Student, Biomolecular interactions)• Rory McNally (MS trainee, Microbiology)• Denise Hogan (MS trainee, Microbiology)• Antoni Montseny (Undergraduate trainee)• David Romero (Undergraduate trainee)• Josep Pamies (Undergraduate trainee)
Applied Biotechnology Innovation Centre
OUR PRODUCTIVITY IN PERSPECTIVE
• PhD Theses: 2,0 (1995-2004)• DEA Theses: 9,0 (1995-2004)• Publications/PDI/year: 2,5 (ISI 1990-1999) • Citations/PDI/year: 21,0 (ISI 1990-1999)
DATA BBG
DATA Catalunya (all areas)• Citations/article/year: 1,7 (1994-1998)
DATA USA (Chemical Engineering source: NRC 1990-94)• Citations/PDI/year: 23,44 (rank #1 U of Minnesota)20,78 (rank #2 Stanford U)
• Publications/PDI/year: 4,6 (rank #1 U of Minnesota)
2,5 (rank #13 SUNY, Buffalo)1,7 (rank #72 U of Tulsa)