Research & Educational Resources at CUMC:Resources at CUMC:

Research Support and Training Opportunities for Junior Investigatorsfor Junior Investigators

Melissa BeggProfessor & Associate Dean for Interdisciplinary Programs

Co-Director, Irving Institute/CTSAM il S h l f P bli H lth f C l bi U i itMailman School of Public Health of Columbia University

September 22nd, 2010

Research ResourcesResearch Resources available through the CTSA

What is the CTSA?What is the CTSA?• A national consortium of medical research

instit tions f nded thro gh NIH’s Clinical andinstitutions, funded through NIH’s Clinical and Translational Science Awards (CTSAs), working together and sharing a common vision to: – Improve the conduct of biomedical research across the country – Reduce the time it takes for laboratory discoveries to become

treatments for patientstreatments for patients – Engage communities in clinical research – Train a new generation of clinical and translational researchers

• There are 46 funded centers now.• There will be ~60 funded centers by 2012.

From the CTSA Fact SheetSheet:

http://www.ctsaweb.org/docs/CTSA_Fact

Sheet.pdfp

What is the Columbia CTSA?What is the Columbia CTSA?

• Columbia CTSA = IRVING INSTITUTE• OVERALL GOALS:

– To transform the culture of research to accelerate the discovery and implementation of new treatments and prevention strategies.

– Key words: y• Interdisciplinary• Translational• Community-engaged• Community-engaged

What are the components of the I i I tit t ?Irving Institute?

• Facilities:• Facilities:– The 10th floor of 2 contiguous buildings (PH and

Harkness)– Adult inpatient and outpatient units– Administrative suite

Bi t iti it ith h kit h– Bionutrition unit with research kitchen– Biomarkers Core lab – Pediatric outpatient unit (and virtual in-patient facility)Pediatric outpatient unit (and virtual in patient facility)– Meeting and teaching space (PH10 stem)

What are the components of the I i I tit t ?Irving Institute?

• Irving Institute Resources:Irving Institute Resources:1. Development of Novel Methodologies Resource2. Pilot & Collaborative Studies Resource3. Biomedical Informatics Resource4. Design & Biostatistics Resource5 R l K l d S & E hi R5. Regulatory Knowledge Support & Ethics Resource6. Clinical Research Resource7 Community Engagement Core Resource7. Community Engagement Core Resource8. Translational Technologies & Resources9. TRANSFORM (educational programs)

WHAT DO THEWHAT DO THE IRVING INSTITUTEIRVING INSTITUTE

RESOURCES PROVIDE?

Development of Novel M th d l i RMethodologies Resource

• Provides salary support to a multidisciplinary team• Provides salary support to a multidisciplinary team of advanced junior and mid-level faculty scientists who develop projects to enhance opportunities for t iteam science

• Sample Projects:Initiating a campus wide effort on research to combat– Initiating a campus-wide effort on research to combat pediatric obesity

– Developing a mentoring program for junior faculty in the Dept of PediatricsDept of Pediatrics

Pilot & Collaborative Studies RResource

• Provides seed funding for innovative• Provides seed funding for innovative, interdisciplinary research efforts – particularly those that bring together new investigative teams

• Key Components:– Pilot Awards: With the CTO, the Irving Institute awards 8 one-year

awards of $50,000 each. $ ,TIMELINE: Announced annually in late Dec/early Jan for March deadline

– CaMPR Awards: Provides 4 team-building grants ($25K) and 2 l i t ($100K) f dd i i t t bl tplanning grants ($100K) for addressing an important problem at

the cellular, individual, and community levels.TIMELINE: Announced annually in July/summer for September deadline

Biomedical Informatics ResourceBiomedical Informatics Resource• Dual roles: Providing information services to

s pport clinical and translational researchsupport clinical and translational research; conducting original informatics research on the nature of research processes and how information services can improve their efficiency

• Key Components:W b P t l Si l t i t f ll I i I tit t ti iti– Web Portal: Single entry point for all Irving Institute activities (http://irvinginstitute.columbia.edu).

– WorkWeb: A unique search engine that incorporates information from HR, publication and grants databases that will allowfrom HR, publication and grants databases that will allow investigators to identify new collaborators (in production)

– Clinical Data Warehouse: Permits users to query data on sets of patients providers, departments, etc., for study planning.

Design & Biostatistics ResourceDesign & Biostatistics Resource• Provides a wide range of design, statistical, and

anal tical s pport ser ices to assist CUMC fac ltanalytical support services to assist CUMC faculty with grant applications and publications

• Key Services:Key Services:– Initial, one-hour consult and up to 5 hours of follow-up

support FREE TO CUMC INVESTIGATORSG t ti i l di h th i iti t d– Grant preparation, including hypothesis writing, study design, analytic plans, and sample size justification (~8 weeks lead time)

– Manuscript writing (~4 weeks lead time)

Regulatory Knowledge Support & Ethics Resource& Ethics Resource

• Provides educational programming, training, and consultation on the entire range of regulatoryconsultation on the entire range of regulatory requirements for the conduct of clinical and translational researchT i i d lt ti il bl i th f ll i• Training and consultation are available in the following domains:– Regulatory/FDA requirementsg y q– Research ethics (also provides pilot funding)– Human subjects protection/IRB issues– Clinical Trials Office/conduct of clinical trials– Clinical Trials Office/conduct of clinical trials– Science and Technology Ventures (STV) for technology transfer

(also provides funding for supportive studies

Clinical Research ResourceClinical Research Resource

• Provides research space and support to expedite p pp pand facilitate the collection of quality data in clinical and translational researchKey Components:• Key Components:– Inpatient and outpatient space for adult and pediatric

studies– Highly specialized research nursing services– Clinical study coordinators– Phlebotomy services– Support for off-site studies in the ED, ICU’s

Community Engagement Core ResourceResource

• Organizes and guides investigators within and outside of CUMC ho are in ol ed in comm nit based research in orderCUMC who are involved in community based research, in order to enhance research efforts and more effectively communicate with our community partnersKey Components:• Key Components:– Consultation services– Pilot awards for community researchers– NEW community center, CCPH = Columbia Community

Partnership for Health, at 390 Ft. Washington Ave, featuring:• A bilingual health library, health-related internet access for

it id t i t i d f hcommunity residents, interview and exam rooms for research, conference rooms for health-related lectures and events, pilot grants for training and research

Translational Technologies RResource

• Provides increased access and support to core• Provides increased access and support to core facilities campus-wide

• Key Components:y p– Biomarkers Core– Clinical Genetics core– Imaging Core– Research Pharmacy

Access to and pilot support for additional cores through– Access to and pilot support for additional cores through the Herbert Irving Comprehensive Cancer Center: confocal microscopy, flow cytometry, genomics technologies & cytogenetics proteomicstechnologies & cytogenetics, proteomics

TRANSFORM Educational RResources

• Provides long-term and short-term training and mentoring opportunities to a wide range of clinicalmentoring opportunities to a wide range of clinical and translational investigators, from pre-docs to junior faculty

• Key Components:– K12 Mentored Career Development Award for Assistant

Professors (announced in fall for July 1 start)– T32 Crossover Training Certificate for pre-doctoral students in

basic and population sciences (announced in January for July 1 start)MS in POR: Master of Science in Patient Oriented Research– MS in POR: Master of Science in Patient Oriented Research (application deadline January 5th)

– Short-Term training opportunities (e.g., Reach for the R, Summer Institute, courses)st tute, cou ses)

Educational Opportunities

Training OpportunitiesTraining Opportunities

• LONG-TERM OPTIONS:LONG TERM OPTIONS:– Master’s degree programs at MSPH– CTSA/K12 Mentored Career Development AwardCTSA/K12 Mentored Career Development Award

• SHORT-TERM OPTIONS:CSRI: Columbia Summer Research Institute– CSRI: Columbia Summer Research Institute

– Reach for the First R01Individual Courses at the Mailman School & CTSA– Individual Courses at the Mailman School & CTSA

Master’s Degree Programs• For fellows and junior faculty• Most relevant programs:p g

– MS in Patient Oriented Research (30 pts)– MPH (45 pts) or MS (30 pts) in Epidemiology

MS i Bi t ti ti Cli i l R h M th d T k (30 t )– MS in Biostatistics: Clinical Research Methods Track (30 pts)– MPH in General Public Health – GPH (45 pts)– MPH in Effectiveness & Outcomes Research (45 pts)( p )

• Cost: $1286 per credit plus fees (2010-2011)• Web Site for Descriptions:

http://mailman columbia edu/academics/degree offeringshttp://mailman.columbia.edu/academics/degree-offerings• Web Site for Applying:

http://mailman.columbia.edu/prospective-students/applying-school

CTSA K12 AwardCTSA K12 Award• For junior faculty (Assistant Professors) only • Program offers:

– Two years of salary support (75% effort) plus funds for tuition, research costs, travel, etc. ($25K/year)

– Didactic training (MS/POR for those without research Master’s)– Research rotations– Mentored research project– Colloquium on Career Developmentq p– Assistance with independent grant application

• Next Deadline: ? (waiting on pending application; there will be a campus-wide e-blast)be a campus wide e blast)

• Web site: http://irvinginstitute.columbia.edu/education/overview.html

CSRI: Columbia Summer Research InstituteColumbia Summer Research Institute • For post-doc fellows and junior faculty• Intensive 5-week summer training programg p g• Curriculum includes:

biostatistics, epidemiology, race and health, decision and cost-effectiveness analysisy

• Earn 10 academic pts; can be used towards summer certificate or full degree program (30-45 pts)

• Cost: $13 250 in 2010; 2011 rates not yet availableCost: $13,250 in 2010; 2011 rates not yet available(can be applied towards a degree program)

• Next offering: JULY 2011A li ti d dli M 15th 2011• Application deadline: May 15th, 2011

• Email: csri@columbia.edu• Web Site: http://csri.cumc.columbia.edu/ p

Reach for the First R01Reach for the First R01• Non-credit course, offered twice per year: fall and spring• Eligibility: Must be an Early Stage Investigator as per NIH:

http://grants.nih.gov/grants/new_investigators/index.htm• Must be supported/recommended by a senior faculty member • Up to six junior investigators will be selected for this course eachUp to six junior investigators will be selected for this course each

term, across all departments. • Advantages: Successful applicants will receive 5 free hours of

biostatistical consulting access to other Irving Institute Resources 2biostatistical consulting, access to other Irving Institute Resources, 2 expert pre-reviews on their R01 applications, and a bi-monthly meeting to ensure structure and timeliness in completing the tasks required to submit a first application.

• These resources are intended to enhance, rather than replace, appropriate mentoring. An applicant without excellent mentoring cannot be seen as competitive for this course.

Taking Single Courses for Credit• For fellows and junior faculty

Most pop lar choices itho t prereq isites• Most popular choices without prerequisites:– P6103 or P6104: Introduction to Biostatistics

P6400 P i i l f E id i l I– P6400: Principles of Epidemiology I – P6530: Issues & Approaches in Health Policy &

ManagementManagement– P8102: Basic Laboratory Methods in Clinical &

Translational Research– P8146: Drug Development from a Pharmaceutical

Perspective

Taking Courses for Credit• Most popular choices with prerequisites:

– P8140: The Randomized Clinical Trial (prerequisite isP8140: The Randomized Clinical Trial (prerequisite is P6103/4)

– P8450: Clinical Epidemiology (prerequisites are P6400 P6103/4)P6400, P6103/4)

– P8568: Decision Analysis for Clinical & Public Health Practices (prerequisite is P6103/4)Practices (prerequisite is P6103/4)

• Cost: $1286 per credit plus fees (2010-2011)• Must apply as a special/non-degree student; seeMust apply as a special/non degree student; seehttp://mailman.columbia.edu/prospective-students/applying-

school/faq

How do I access these t i f ?resources or get more info?

• To access the CTSA research resources visit the web site:• To access the CTSA research resources, visit the web site:http://irvinginstitute.columbia.edu

http://irvinginstitute columbia edu/resources/resources htmlhttp://irvinginstitute.columbia.edu/resources/resources.html• Fill out the request form on the web site for consultation or

more information. • To find out more about courses at MSPH, visit the website:

http://www.mailman.columbia.edu• Or contact the school at:

ph-admit@columbia.edu