Research Highlight• Medical Device: Focused Ultrasound Enhance Therapeutic Nanocarrier

Delivery for Brain Tumor Treatment

MNP-Epirubicin design

R2 MR relaxometry map to quantitatively estimate drug concentration

Tumor, without FUS/MT Tumor, with FUS/MT

Reference: H-L Liu, M-Y Hua, H-W Yang, et al, “Magnetic resonance monitoring of focused ultrasound/magnetic nanoparticle targeting delivery of therapeutic agents to the brain,” Proceedings of National Academy of Science USA, Vol. 107, No. 34, pp.15205-15210, 2010 (IF=9.737, 4/56 in “Multidisciplinary sciences”).

CW-Laser

Traditional FUS alone FUS+Nanocarrier

Hyperthermia amplification

MRI

FUS

Survival

Magnetization

Reference: H.W. Yang, M.Y. Hua, T.L. Hwang, et al, H.L. Liu*, K.C. Wei. Noninvasive synergistic treatment of brain tumor by targeted chemotherapeutic delivery and amplified focused ultrasound-hyperthermia using magnetic nanographene oxide. Advanced Materials, Vol. 25, No. 26, pp.3605-3611, 2013. (*Corresponding author; IF=14.829, 6/152 in “Materials Science, Multidisciplinary").

Research Highlight• Medical Device: Combined Ultrasound Brain Drug Delivery and Hyperthermia Amplification to Enhance Brain Tumor Treatment

Research Highlight• Medical Imaging: Treatment of infarcted myocardium with stem cell

sheets and MRI-based evaluation

Stem cell sheets transduced with VEGF is capable of restoring the cardiac functions in infarcted rabbit myocardium, as the therapeutic effects are measured and confirmed with MRI

Reference: Yeh TS, Fang YH (co-first author), Lu CH, Chiu SC, Yeh CL, Yen TC, Parfyonova Y and Hu YC. Baculovirus-transduced, VEGF-expressing Adipose-derived Stem Cell Sheet for the Treatment of Myocardium Infarction. Biomaterials. Jan; 35: 174-184, 2014 (SCI = 7.6; 2/79)

Research Highlight• Medical Imaging: Advanced image analysis of PET imaging for cancer

prognosis

Reference: Cheng NM, Fang YH (co-first author), Chang JT, Huang CG, Tsan DL, Ng SH, Wang HM, Lin CY, Liao CT and Yen TC. Texture features of pretreatment 18F FDG PET/CT images: prognostic significance in patients with advanced T-stage oropharyngeal squamous cell carcinoma. Journal of Nuclear Medicine. Oct; 54(10):1703-9, 2013. (SCI=5.77; 6/120)

Texture parameter of uniformity can predict progression free, disease specific, and overall survivals in oropharyngeal cancer

Open-source project for software development of texture analysis

Research Highlight

Reference: Woei-Luen Chen and Jhe-Shuan Lin, “One-dimensional optimization for proportional-resonant controllers design against the change in source impedance and solar irradiation of PV systems,” IEEE Trans. on Industrial Electronics, 2013.DOI: 10.1109/TIE.2013.2264789  (SCI: 5.165; Rank #3 in all IEEE Transactions)

Solar Array

SwitchingPatterns

id*

sinθv

cosθv

iq*

ε

i

i*

vdc 11

ip

KKs

vdc*

vdc

|v| Δv

22

ip

KKs

ve*

DC Voltage Regulator

AC Voltage Regulator

|v|* =1.0 p.u.

vdc

idcMPPT

ODO Eqs. (20),(22), and (23)

2 20

pbsK

s

Phase Shifter

Cdc

Cf

Lf

Lx viPCC

Series Filter

if idc

vdc

UnipolarSPWM

Pyranometer

Phase Detector

αβ dq

θv

vd

vq

vβ vα

v

SPLLdq axes® α axis

PR Current Controller

Cy

L

vs ve

S1

S4

S3

S2

ch1►

ch2►

ch3►

vdc

v

i

ch1: 500V/div, ch2: 200V/div, ch3: 5A/div, timebase: 10ms/div

ch1►

ch2►

ch3►

vdc

v

i

ch1: 500V/div, ch2: 200V/div, ch3: 5A/div, timebase: 10ms/div

103 104 105 10610-3

10-2

10-1

100

101

(rad/s)

W j23

M j

10

104

100

(rad/s)

M j W j

2310

11

c LG j G j

Adaptability to the change in source impedance

Adaptability to the change in irradiation

Robust Stability Analysis

3

2n x

P xo

LK r

2 2 22 1n x o x x Pb L L a r K

2n o

Closed-form solution to the control gains

• Industrial Electronics: Digital Adaptive Solar Energy Converter Design/ 數位適應型太陽能變流器之設計

Research Highlight

Reference: Woei-Luen Chen and Cheng-Zhang Xie, “Active voltage and frequency regulator design for a wind-driven induction generator to alleviate transient impacts on power grid,” IEEE Trans. on Industrial Electronics, vol. 60, no. 8, pp. 3165-3175, 2013. DOI: 10.1109/TIE.2012.2200212 

0 0.02 0.04 0.06 0.08 0.1 0.12 0.14 0.16-1

0

1

0 0.02 0.04 0.06 0.08 0.1 0.12 0.14 0.16-1

0

1

0 0.02 0.04 0.06 0.08 0.1 0.12 0.14 0.16-1

0

1

0 0.02 0.04 0.06 0.08 0.1 0.12 0.14 0.16-1

0

1

vi

vs

vs,1

vi,1

Vector position detection

θ α-axis

β-axis

vα

(1 ,0)

(0 ,1)vαβ

v1αβ

vβ

vα,1

Trajectory of unity 1-norm normalized

voltage vectors

Trajectory of voltage vectors

vβ,11

1v v

v vvv

Normalized one-norm vector

iai

vai

vas

iai

vai

vas

Parallel the IG with Power Grid

iai

vas,vai

iae

iai

vas

iaevai

Parallel the IG with Power Grid

iai

vai

vas

iaivai

vas

Disconnecting the IG from Power Grid

iai

vas,vai

iae

iai

vas

iaevai

Grid disconnection instant Grid connection instantWithout AVFR With AVFR With AVFRWithout AVFR

• Industrial Electronics: Wind-Driven Induction Generator to Alleviate Transient Impacts on Power Grid/ 零暫態併網風力發電系統設計