research in motion - connecting repositories · comparative orthopaedics • identify “real...
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Research in Motion
B. Sonny Bal, MD, JD, MBA
Associate Professor
Department of Orthopaedic Surgery
University of Missouri School of Medicine
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Great Expectations
Life expectancy is now 77.7 years … and people are expecting to stay actively moving through those years.those years.
Aging baby boomers expect to stay active, placing unprecedented demands on surgical options previously reserved for the elderly.
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Total Hip Replacement
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Knee Replacement
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Joint Replacement Advances
• Materials (Failure)
• Bearings (Wear)
• Surgery
– Infection
– DVT– DVT
• Today:
– Biomaterials
– Bearings
– Safe Surgery
• Future?
– Biological solutions
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Meeting Demand for Ortho R&D
• Biomaterials– Mimic skeletal bone (elasticity, porosity)
– Bearing wear and compatibility
– Biological options
• Surgical techniques and procedures– Less invasive surgery and faster recovery
• Patient education and rehabilitation– Consumers are better informed
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Collaborative Research
• Orthopaedic scientists and surgeons
• Engineering and materials scientists
• Veterinary medicine scientists and clinicians
Working together.
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Collaboration
Comparative Orthopaedics Laboratory-MUMissouri University of Science & Technology-Rolla
Department of Orthopaedic Surgery-MU
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Empty Control
Implanted
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BiomaterialsBiomaterials
OC plugs in RabbitsOC plugs in Rabbits
–– Regenerate CartilageRegenerate Cartilage
–– Bioactive GlassesBioactive Glasses
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Tissue-engineered patella
• Columbia University
New York City
• COL at MU
Columbia, MO
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Stem Cell Engineered CartilageStem Cell Engineered Cartilage
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Comparative Orthopaedics
• Identify “real world” problems
• Develop hypothesis and aims
• Break it down into the components
• Assess the variables to test the hypothesis• Assess the variables to test the hypothesis
• Optimize the solutions
• Apply it to the problem
• Test the solution in the real world
• Stakeholders: Veterinary and Human
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Ceramic-Metal Femoral Head
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Material Composites
• Optimizing Bioactive Glasses
• Testing tissue-engineered cartilage
• Combining biomaterials
– Bioactive glass– Bioactive glass
– Porous titanium
– Biologically active materials
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The Value of Investigation?
#1 Disability: Arthritis
Leading Cause of Death: Heart Disease
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The Case for Moving Forward
57% of adults with heart disease also have
arthritis
Arthritis = difficulty being physically active
Less active = difficulty managing heart disease
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Investments in Motion
Government grants
Foundation grantsFoundation grants
Corporate giving
Individual giving
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Research to Products
• Once we have the biomaterials:
• MU Biodesign Team
– New applications
– New solutions– New solutions
• Business Incubator
– Business School
– Commercial Venture
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Investments in Motion