research in the emory school of medicine david stephens jeff sands trish haugaard october 2006
TRANSCRIPT
Research in the Emory School of Medicine
David StephensJeff Sands
Trish HaugaardOctober 2006
VA-Research CtrCRCA/MSCR/K30/K12
Yerkes PrimateResearch Ctr.
CDC
Emory UniversityHospital
Crawford LongHospital
GCRC
Wesley Woods
1979: $105M Woodruff gift
1986: 5th strategic plan for research: goal - national prominance
1986: Juha Kokko, Chair Dept. Medicine
1988: Jeff Houpt, Dean
1990-95: 9 new chairs appointed; new space – Rollins Bldg & WRMB wing
Research progress at Emory SOM
1996: Tom Lawley, Dean; Mike Johns, VP WHSC
1997: 6th Strategic plan for research: goal – expand workforce
1996-05: 14 new chairs appointed; >160 new NIH-funded investigators
1996-05: new space: Vaccine Center, Whitehead, WCI, Pediatrics, Yerkes Neuroscience; lose space – A&P building
1999: Biomed. Engineering Department, Don Giddens Chair
2000: EmTec-Bio incubator
2003: 7th strategic plan for research: goal – team science
2005: capital campaign
Growth rate of NIH funding 1996-2005 benchmark Schools
Emory Univ.Vanderbilt Univ.Univ. of PittsburghBaylor CollegeDuke Univ.Univ. of Penn.Washington Univ.Johns Hopkins U.Univ. of NCStanford Univ.UABYale Univ.
55 71 99 89128149162204 10413298
159
190244288257350399378449217264191298
14.8%14.8%12.6%12.5%11.9%11.6%9.8%9.2%
8.6% 8.0%7.7%7.2%
Rank SOM1996 2005
Ave. AnnualCompound
Growth Rate$ millions
1915 9
13 5 2 4 1171118 7
Top-20 ranked SOM departments (2005 NIH Funding)
• Otolaryngology (3)• Emergency Medicine (3)• Surgery (8)• Dermatology (9) • Pathology & Lab Medicine (8)• Neurology (11)• Urology (11) • Physical Medicine &
Rehabilitation (14)• Psychiatry & Behavioral Sciences
(17)• Neurosurgery (20)
• Biomedical Engineering (1)• Microbiology & Immunology
(7) • Pharmacology (11)
Clinical departments Basic science departments
Selected recent achievements
2005• Top 10 “best work environment for postdocs” – The Scientist• $25M for cancer nanotechnology (S Nie)• $11.5M for cardiovascular nanomedicine (G Bao)• $9M for small molecule discovery (R Dingledine)• $7.4M for Alzheimer’s Center (A. Levey)• $525M received for sale of 3TC (D. Liotta, R. Schinazi)
2004• Chris Larsen “Roche Basic Science Award” by Amer. Soc. Transplantation• $4.9M to develop drugs for depression (C. Nemeroff)
2003• $16M for vaccine research (R Ahmed)• $12M for emerging infections and bio-defense• $10M + $7.6M for prostate metastasis study (L Chung, J Simons)• $7M for alcohol link to acute respiratory distress syndrome (M Moss)
Selected recent achievements
2006• $7.5M to WCI Lung Cancer Research• $10M to Emory’s Transplant Center, Vaccine Center, and
Yerkes for development of new vaccine strategies• 42 SOM investigators now have $1M+ in NIH awards• Vision 2012 – two new research buildings proposed
– 1523 Clifton Road
– As part of the new Medical Research Complex
Strategic Plans for Research
1946 Glenville GiddingsDevelop SOM on Emory
campus, not Grady
1952 Boisfeuillet Jones Establish Emory Clinic
1960 Boisfeuillet Jones Build new space
1967 Art Richardson Improve quality, not quantity
1986 Ken Walker Strive for national prominance
1996Wright Caughman &
Ray Dingledine Expand research workforce
2003Wright Caughman &
Ray DingledineFocus on team science &
translational research
2003 Strategic Plan for Research
Goal• Accelerate our progress towards top-tier status as a
medical research enterprise
Mechanisms• Grow space, infrastructure and investigators• Promote translational & team science
Strategic Plan for Research: 2008 goals
Culture• Improve integration of research and clinical missions
People• Increase the number of NIH funded investigators by ~100
• Attend to retention as well as recruitment
• Increase # grad students from 322 to ~500, MD/PhDs from 8% to 12% of entering class, and postdocs from 420 to 630
Programs• Build new research space (550,000 gsf)
• Build team science research from 18 to 25% of NIH income
• Increase investment in enabling technologies & research cores
Seven Research Areas for Emphasis
1. Cancer
2. Neurosciences
3. Immunity and Host Defense
4. Cardiovascular and Epithelial Biology
5. Regenerative, Transplantation and Reparative Medicine
6. Integrative Medicine and Health Services Research
7. Molecular Structure and Interactions
Plan of Action for NIH RFA for Clinical and Translational Science Award (CTSA)
The purpose of this initiative is to forge a
uniquely transformative, novel and
integrative academic home for clinical
and translational science.
CTSAIt should:
1. Captivate, advance and nurture a cadre of well-trained multi- and inter-disciplinary
investigators and research teams.
2. Create an incubator for innovative research tools.
3. Synergize multi- and inter-disciplinary clinical and translational research.
CTSA
• U54 Cooperative Agreement Mechanism
• Application Due January 2007
• $6 million/yr. for 5 years total costs
• 8 awards made in 2006
• NIH plans to award up to 60 awards by 2010-2012
Research Resources
• Clinical Trial Office (Peter Block)
• GCRC (Arlene Chapman)
• Research core facilities
• Microchemical and proteomics • BIMCORE• DNA sequencing• Flow cytometry• Microscopy• Animal imaging• Biomedical imaging technology MRI center• PET center• Transgenic mouse• Human tissue procurement & banking• Human embryonic stem cell
Additional SOM CORE FACILITIES
• Animal Imaging• BIMCORE• Biomedical Imaging Technology Center• DNA Sequencing• Flow cytometry• Human Tissue Procurement & Banking• Microchemical & Proteomics• Microscopy• MRI Center• Positron Emission Tomography Center• Transgenic Mouse & Gene-Targeting
NEW CHALLENGES
• NIH FUNDING • Budget growth shrinking• 90% of grant applications not funded• 1% across-the-board cut on all discretionary
spending translating into a $286M reduction in NIH spending
NEW CHALLENGES
• Grants.gov• Electronic Submission system not ready• SR424 very different than PHS398• Change from % effort to # of person months• No internal electronic routing system (yet)• Earlier internal submission deadlines required
GRANT POINTERS
• Submit your grant to multiple funding agencies, such as NIH, VA, AHA, others
• Write your grant at least a month in advance of the deadline• Have people who know the field read it• Have people NOT in the field read it• Do not submit just to submit – it is better to
get it right (or close) than to get triaged