research & knowledge exchange report · lottery-funded well london programme which is working...

Research &

Knowledge Exchange

Report

2013

School of Health, Sport and Bioscience

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Professor Neville Punchard Dean of School

Professor Wendy Drechsler Associate Dean for Research and Knowledge Exchange

Professor Adrian Renton Director, Institute for Health and Human Development (IHHD)

Professor Angela Harden Professor of Community and Family Health, IHHD and Newham University Hos-pital NHS Trust

Professor Duncan Turner Professor of Restorative Neuroscience and Rehabilitation

Professor Keith Gilbert Professor, Sport & Disability

Professor Olivia Corcoran Professor, Bioanalytical Chemistry

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Introduction

In the School of Health, Sport and Bioscience we are committed to deliver and promote Research and Knowledge Exchange in line with UEL’s Strategic Plan for Research (2010-2015). Our research is focused on improving health and wellbeing. Research areas include: public and community health, physiotherapy, po-diatry, rehabilitation, medical biosciences, biotechnology, forensic science, applied sports science and pharmacognosy.

The School is preparing for the upcoming Research Excellence Framework (REF) submission in November 2013 and hopes to submit almost triple the number of staff compared with our submission in RAE 2008.

Our research is carried out at national and international levels, and undertaken with a variety of partners including the NHS, industry and other UK and overseas universities. We continue to focus our research around the strengths of our institute (IHHD) and research groups, ensuring that we have viable and sustain-able areas of research and a successful submission to REF 2014.

Professor Wendy Drechsler

October 2013

Contents

Page

Institute for Health and Human Development (IHHD) 4

Human Motor Performance Group (HMPG) 6

Medicines Research Group (MRG) 8

Infection and Immunity Research Group (IIRG) 10

Neurorehabilitation Unit (NRU) 12

Applied Sport Sciences Research Group (ASSRG) 13

Learning and Teaching Research Group 14

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Institute for Health and Human Development (IHHD)

Group Research Interests The Institute of Health and Human Development is a multi-disciplinary group with staff backgrounds in epidemiology, psychology,

sociology, economics, public health, statistics and community development. The group conducts research and development into

health and well-being improvement and have a commitment to community participation in co-designing research and interven-

tions; a focus on the wider social determinants of health; and methodological expertise in the evaluation of complex interventions,

the integration of qualitative and quantitative data and systematic reviews. The Institute is the lead academic partner in the Big

Lottery-funded Well London Programme which is working to promote health in 20 of the most deprived areas across London

through an integrated community development approach. It leads the scientific evaluation of the Programme which is designed on

a pair-matched Community Randomised Controlled Trial with nested qualitative case studies funded by the Wellcome Trust. With

an established programme of systematic review work on interventions tackling the wider determinants of health, the institute is

contributing to the development of international standards for evidence synthesis and complex interventions. Internationally, the

Institute’s evaluation research in India is influencing reform of health financing programmes for the ‘below poverty line’ popula-

tion.

Group news - Impacts

IHHD’s Well London Programme has created a strong legacy, influencing the ways in which health and local authorities design and

deliver services for deprived communities in London, and driving policy and commissioning towards use of asset-based community

development approaches and action on wider determinants of health. Further Big Lottery funding was recently granted for a sec-

ond phase that extends the Programme to eight new areas in London.

The Francis Crick Institute, a partnership between University College London, Imperial College, King’s College London, the Well-

come Trust, the Medical Research Council and Cancer Research UK, has recently commissioned UEL to deliver a community en-

gagement project based on the Well London model.

Evidence from our systematic review programme has been cited by the Scottish Parliament, Marmot review and others and is driv-

ing both policy and intervention design in relation to teenage pregnancy.

Recommendations from our policy research on primary care models in India led to direct discussions between UK and Indian Prime

Ministers and agreement to share primary know-how and the UK-India CEO Forum adopting primary care development as its top

priority.

Grants & Collaborations

Girls’ health in the school environment: an exploratory case study. UEL Early Career Research Accelerator Grant; £8219,

May 2012 - September 2012.

Health economic and further statistical analysis of the Well London Trial. Wellcome Trust, £158000, June 2012.

Technical and management support to implement the Madhya Pradesh health sector reform programme. Family Health

International; £10450, August – December 2012.

Knowledge exchange project on the neighbourhood impact of Creative Enterprise Centres. Arts and Humanities Research

Council and Netherland Organisation for Scientific Research (NWO); £40000, August 2012-July 2013

Evaluation of the Rajiv Aarogyasri Health Insurance. Access Health International; £18000, September 2012.

Primary Care scoping study, Kerala, India. Department for International Development; £29000, October – December 2012.

Greenwich Assets Model development: Phases I & II. NHS Greenwich; £48000, October 2012 – August 2013.

Creative approaches to young people’s health research: training and development. UEL Early Career Research Accelerator

Grant; £9259, November 2012 - July 2013.

Queen Mary Avenue Estate community engagement. Circle 33 Housing Trust; £3500, March – June 2013

Engaging health and social care professionals in the Joint Strategic Needs Assessment. London Borough

of Barking and Dagenham & NHS Barking and Dagenham; £19000, April – June 2013

Heart in the Community CVD prevention project. NHS Waltham Forest, £15000, April – July 2013

Development of the Crick Living Centre. The Francis Crick Institute; £92000, April – July 2013

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Well London CADBE (Consultation, Assessment, Design, Brokerage and Enterprise). Greater London Assembly/Big Lottery,

£18350.

Well London Legacy Strategy Phase 2. Greater London Authority/Big Lottery; £79000,

Well London Phase 2 programme. UEL HSB Research and Knowledge Exchange grant; £8000, April – July 2013

Conference & Invited Talks

Bertotti M, Han Y. Governance models in South Korean Social Enterprises: are there alternative models?, CEEDR seminar series, Middlesex University, 27th April 2013

Watts P, Phillips G, Petticrew M, Hayes R, Bottomley C, Yu G, Schmidt E, Moore D, Frostick C, Lock K, Renton A. The relation-ship between greenspace and physical activity in deprived communities in London. WHO Health Enhancing Physical Activity Conference, Cardiff; September, 2012.

Jamal F, Bertotti M, Harden A. Critical reflection of the meta-narrative review: a case of the meanings and conceptualisa-tions of community. Oral presentation at Social Science Research Unit, Institute of Education, UCL, May 2012.

Jamal F, Fletcher A, Bonell C, Harden A. et al. The process through which schools impact young people’s health: a meta-ethnography approach. Oral presentation at Department for Social Policy and Social Intervention, University of Oxford, May 2012.

Nijkamp J, Bertotti M (2012). Lessons learnt from the experience of two creative hubs: London and Rotterdam. RAAK Every-body on Board Symposium. Rotterdam, 29th April 2012.

Selected Publications

Sampson A, Harden A, Tobi P, Renton A (2012). Promoting a healthy legacy for the Olympic Park: findings from a pre-games study. Perspectives in Public Health 132: 64. Phillips G, Renton A, Moore DG, Bottomley C, Schmidt E, Lais S, Yu G, Wall M, Tobi P, Frostick C, Clow A, Lock K, Petticrew M, Hayes R (2012). The Well London program - a cluster randomized trial of community engagement for improving health behaviors and mental wellbeing: baseline survey results. Trials, 13:105. Phillips G, Petticrew M, Draper A, Derges J, South J, Adams-Eaton F, Sheridan K, Renton A, on behalf of the Well London Trial Inves-tigators Group (2012). What is complexity and what do you do with it? Reflections on use of controlled trials to assess complex public health interventions. The Lancet; 380: S65. Cooper K, Shepherd J, Picot J, Jones J, Kavanagh J, Harden A, Barnett-Page E, Clegg A, Hartwell D, Frampton G, Price A (2012) An economic model of school-based behavioral interventions to prevent sexually transmitted infections. International Journal of Tech-nology Assessment in Health Care, 28:4. Picot J, Shepherd J, Kavanagh J, Cooper K, Harden A, Barnett-Page E, Jones J, Clegg A, Hartwell D, Frampton G (2012) Behavioural interventions for the prevention of sexually transmitted infections in young people aged 13–19 years: a systematic review. Health Education Research 27(3): 495-512.

Group Members

Prof Adrian Renton Prof Angela Harden Prof Mala Rao Prof Gopal Netuveli Gail Findlay Kevin Sheridan Dr Marcello Bertotti Dr Patrick Tobi Farah Jamal Bethan Hatherall Younghee Han Faye Adams-Eaton Ruby Farr Ifeoma Dan-Ogosi Dr Paul Watts Dr Nena Foster

uel.ac.uk/ihhd

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Human Motor Performance Group (HMPG)

Group Research Interests

The Human Motor Performance Research Group (HMPG) is a multidisciplinary team of clinical scientists with backgrounds in physiotherapy, podiatry, exercise physiology and biomechanics. We investigate how physical factors impact physiological and bio-mechanical function across the lifespan. Evaluation of physical interventions to mitigate the effect of disease and trauma are also central to the work of HMPG. Key research themes include

the effect joint bleeding on physiological and biomechanical function in children, adolescents & young adults with haemophilia

the manifestation of disease on the growth, development and function of the paediatric foot and lower limb

understanding factors that can influence walking and lower limb biomechanical function in a variety of conditions across the life span

the impact of stroke on dimensions of physical fitness and the therapeutic use of exercise to alleviate the effects of neurologi-cal illnesses.

Group news - Impacts

Currently, the principal impact of our research into Haemophilia has been on shaping clinical evaluation and service delivery in the local and national context. Dissemination of our research for The Haemophilia Society and UK Haemophilia Centres was seminal in convincing UK therapists to monitor physical outcomes using evidence-based clinical assessment. These dissemination activities of our research have supported change now evident in current haemophilia service delivery:

Jan 2013, Dr Stephensen established a UK Haemophilia Physiotherapy Advisory Board which has developed a “Train the Trainer” programme to educate UK physiotherapists in the assessment and treatment of people with haemophilia based on UEL research.

Biomechanical function of the foot and lower limb in children with obesity is a key area for Dr Stewart Morrison and colleagues. Having recently completed a three year project exploring the impact of obesity on the three-dimensional function of the paediatric foot, novel understanding of the impact of obesity is emerging. This work is ongoing through grant funding from the Dr William M Scholl Podiatric Research and Development Fund which will assist the translation laboratory research into clinical practice.

Focus on the function of the foot and lower limb in mobility in adults is being advanced through new funded collaborations. In con-junction with colleagues at Plymouth University, Drs. Cramp and Morrison have commenced a new programme examining the ef-fects of foot and ankle impairments on mobility and balance in community dwelling adults post stroke. This builds on existing work on factors that can influence walking in a variety of conditions and the impact of stroke on dimensions of physical function and physical treatment options. Drs. Cramp and Morrison are also working in collaboration with ASICS Corporation to advance study of in-shoe foot motion and in the influence of footwear on foot and lower limb biomechanics. This new work offers exciting possibili-ties for both clinical and sporting application.

Working with the rheumatology team at Great Ormond Street Hospital, Dr. Jill Ferrari is leading a research project investigating the impact of muscle weakness on the foot and gait in Juvenile Dermatomyositis. This involved collaboration with local schools to measure normal foot and gait parameters and will start the development of further work into podiatric management in muscu-loskeletal and inflammatory conditions affecting the child’s foot.

Grant Funding

Bowen (PI, University of Southampton), Drechsler Stephensen, Arden (University of Oxford), Doherty (University of Notting-ham) (2012- 2015). Chingford Study: The epidemiology and lifetime risk of foot osteoarthritis and associated lower limb biomechanical factors. Dr. William M. Scholl Podiatric Research and Development Fund £214,233 (£99,698 to UEL)

Drechsler, Stephensen, Bowen (Uni of Southampton), Izod (Sept 2012-Sept 2015). What is the impact of early adult rheuma-toid arthritis on the biomechanical and functional characteristics of the foot and lower limb? Dr. William M. Scholl Podiatric Research and Development Fund £132,403

Morrison, Cramp (2012-2015). The influence of running shoes on the biomechanics of the foot and lower limb. ASICS/UEL PhD Studentship (£45,000)

Cramp, Morrison, Marsden (University of Plymouth), Freeman (University of Plymouth), Paton (University of Plymouth) (2012-2015) The effects of foot and ankle impairments on mobility and balance in community dwelling adults post stroke: a personal and multi-disciplinary approach. Dr William M Scholl Podiatric Research and Development Fund £164,265

Cramp, Lyddon, Hunter (2012) Quantitative gait analysis for community based rehabilitation: a feasibility study of older adults. £1,400 UEL UG Research Internship.

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Mahaffey, R., Morrison, S.C., Drechsler, W., Cramp, M. Motion of the Paediatric Foot during Gait: Associations with Obesity. European Congress of Obesity. May 2013.

Morrison, S.C., Cousins, S.D., Drechsler, W. Foot loading is altered in overweight and obese children: findings from plantar pres-sure analysis. European Congress of Obesity. May 2013.

Stephensen, D. Invited to present ‘diagnosis and evaluation of muscle impairment in children with Haemophilia’ at the Muscu-loskeletal Congress of the World Federation of Haemophilia in Chicago. April 2013.

Suckling, L.B., Stephensen, D, Cramp, M.C., Drechsler, W.I. Muscle strength, architecture and neuromuscular function in adoles-cent boys with haemophilia following lower limb joint haemarthrosis. World Federation of Haemophilia Musculoskeletal Congress, Chicago, United States of America. April 2013

Mahaffey, R., Morrison, S.C., Drechsler, W., Cramp, M. Comparison of skin mounted and virtual markers to track the anterior su-perior iliac spine (ASIS) in obese and non-obese boys. Clinical Movement Analysis Society UK and Ireland. Glasgow, UK. April 2013.

Culpan, J., Bateman, A., Dawes, H., Greenwood, R., Scott, O.M. Minimum levels of mobility and function for successful exercise testing in adults with acquired brain injury . Physiotherapy UK Chartered Society of Physiotherapy Annual Conference. Liverpool, UK. October 2012.

Ecclestone, C., Morrison, S.C., Ferrari, J., Drechsler, W. Musculoskeletal co-morbidity of the obese child. The Society of Chiropo-dists and Podiatrists Annual Conference. Glasgow, UK. October 2012.

Ferrari J. Chronic Recurrent Multifocal Osteomyelitis: podiatric implications. The Society of Chiropodists and Podiatrists Annual Conference. Glasgow, UK. October 2012.

Griffin, J., Ferrari, J., Drechsler, W. An overview of podiatric manifestations in Juvenile Dermatomyositis. The Society of Chiropo-dists and Podiatrists Annual Conference. Glasgow, UK. October 2012.


Cousins, S.D., Morrison, S.C., Drechsler, W.I. (2012) The reliability of plantar pressure assessment during barefoot level walking in children aged 7-11 years. Journal of Foot and Ankle Research. 5: 8.

Morley, A.S., Tod, A., Cramp, M.C., Mawson, S. J. (2013) The meaning of spasticity to people with Multiple Sclerosis: What can health professionals learn? Disability and Rehabilitation.

doi: 10.3109/09638288.2012.726691

Morris, M.G., Dawes, H., Howells, K., Scott, O.M. and Cramp, M.C. et al. (2012). Alterations in peripheral muscle contractile charac-teristics following high and low intensity bouts of exercise. European Journal of Applied Physiology. 112:1; 337-343

Morrison, S.C., Ferrari, J., Smillie, S. (2012) Are spatio-temporal gait characteristics reliable outcome measures in children with Developmental Coordination Disorder? Pediatric Physical Therapy. 24 (1), pp. 46 – 50.

Stephensen, D., Drechsler, W.I. & Scott O.M. (2012) Comparison of muscle strength and in-vivo muscle morphology in young chil-dren with haemophilia and those of age-matched peers. Haemophilia, 18: e302-310.

Group Members

Dr Mary Cramp Dr Jane Culpan Professor Wendy Drechsler Dr Jill Ferrari Dr Kellie Gibson Dr Tim Hunter Dr Stewart Morrison Prof (Emeritus) Oona Scott Dr David Stephensen

uel.ac.uk/hmpg

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Medicines Research Group (MRG)

Group Research Interests The Medicines Research Group REF2014 outputs embrace translational medicine themes underpinning Global Health across the biomedical disciplines concerning the quality, safety and mechanisms of action for prescription and over the counter (OTC) medi-cines. The Group's multidisciplinary expertise spans drug discovery and development, chemistry, toxicology, pharmacology, micro-biology, pharmacognosy and biopharmaceuticals. Faculty generate consulting and research income and lead partnerships with institutions across London, the UK, Europe, USA, Latin America, Pan-Africa and China.

The focus is primarily on elucidation of inflammation mechanisms underpinning pharmacological and toxicological response at cellular, acellular levels and integrative whole body systems

Investigate drug discovery potential for natural products related to public health promotion and disease prevention as well as disease treatment in emerging economies (of impact in children) and developed economies (of impact in the elderly)

Quality Assessment of optimal product formulations for clinically relevant therapeutic indications.

Group News - Impacts, Grants & Collaborations, Conference & Invited Talks Ayoub S, Colville-Nash P, Botting R and Flower RJ “Hypothalamic prostaglandin E2 synthesised by a cyclooxygenase-1 gene-derived protein is involved in the maintenance of normothermia” 4th European Workshop on Lipid Mediators, Paris September 2012. Ayoub S and Morgan WA “An investigation into the role of novel cyclooxygenase variant proteins in inflammation”, Awarded HSB PhD scholarship for September 2013. Corcoran O, Lyons A, Carpenter R and Culpan J. Translating systems biology of elite athletes from the laboratory to the sports clinic and arena. Poster presented at Biomedical Basis of Elite Performance, London 19-21 March 2012. Corcoran O. "From research to publishable paper" 148th Annual Conference, National Institute of Medical Herbalists, Crewe Hall, Cheshire October 2012. Corcoran O. "The evolution of medicines research in East London." London BioNat Network Meeting, UCL School of Pharmacy, Oc-tober 2012. Dawkins L (Psychology, University of East London) and Corcoran O (MRG, University of East London). An evaluation of the SkyCig electronic cigarette for blood nicotine levels, craving reduction and product satisfaction after acute administration. SkyCig Ltd. £27,750. Flower RJ (Barts & the London Medical School), Seed MP (MRG, University of East London), Ray D (University of Manchester). Mechanisms of dissociated steroid action on Bone. William Harey Research Foundation. Wellcome Trust Seeding Drug Discovery Initiative. £43,777. Flower RJ (Barts & the London Medical School), Seed MP (MRG, University of East London), Ray D (University of Manchester). Mechanisms and translation of dissociated steroids. William Harvey Research Foundation & Wellcome Trust Seeding Drug Discov-ery Initiative. £43,000. Flower RJ (Barts & the London Medical School), Seed MP (MRG, University of East London), Burnet M (Synovo GmbH), Ray D (University of Manchester). Mechanisms of dissociated steroid action on glucose metabolism. William Harvey Research Foundation & Wellcome Trust Seeding Drug Discovery Initiative. £21,000. Sanchez-Medina A, Garcia-Rodriguez RV, Cruz-Sanchez JS, Vázquez-Hernández M and Corcoran O. Wide variability of pharmaco-logically active constituents in commercial herbal products available in Xalapa, Veracruz. Poster presented at MIXIM, Mexico 2012 FAP-176 282. Seed MP (MRG) and El-Shikh M (Barts & The London): HSB Research & Knowledge Exchange Grant: ‘Feasibility study into the role of antigen trapping in the induction of systemic arthritis in mice’. £9,250.

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Seed MP ‘Pre-conditioned MAPK activated protein kinase-2 (MK-2) responses of macrophages to p38 inhibition in the absence of intracellular inhibitor, SB203580.’ and ‘Development of a robust rat model of glucocortiocid induced osteoporosis as assessed by μCT, S.E.M., and confocal LM’. 17th International Conference of the Inflammation Research Association, Bolton Landing, New York. September 2012. Seed MP (MRG) ‘3D imaging methods in quantifying rat femoral bone architectural changes associated with prednisolone admini-stration: microCT, SEM and confocal LM. International Workshop on Musculoskeletal and Neuronal Interactions 2013, University of Ipswich. Thompsett AR, Casalotti S, Rahman MM. UEL Summer Research Internships 2013. (£2,000 each). Torres V (PI) and Corcoran O. Investigations into the pharmacological properties of Rhoeo discolour, a Mexican plant used in phy-tomedicine. CONACyT, the Mexican Science Research Council. £25,000. Dr. Seed has been elected to the Council of the British Pharmacological Society, invited to be a member of the RSPCA Rheumatoid Arthritis Working Group and represented the British Inflammation Research Association at the Board meeting of the 17th Interna-tional Association of Inflammation Societies, Bolton Landing, Albany, USA. September 2013. Dr. M Seed and Prof. N Punchard or-ganised and chaired the BIRAs Symposium ‘Inflammation in Sport’ at the International Convention on Science, Education and Medicine in Sport (ICSEMIS) 2012, the medical conference associated with the Olympic Games.


Adebola O, Corcoran O and Morgan WA (2013). Protective effects of prebiotics inulin and lactulose from cytotoxicity and genotox-icity in human colon adenocarcinoma cells. Food Research International. 52:269-274. Bolton C, Wood EG and Ayoub SS (2012). N-methyl-D-aspartate (NMDA) receptor involvement in central nervous system pros-taglandin production during the relapse phase of chronic relapsing experimental autoimmune encephalomyelitis (CR EAE). Funda-mental & Clinical Pharmacology, doi: 10.1111/j.1472-8206.2012.01050. Hesketh S, Thompsett AR and Brown DR (2012). Prion protein polymerisation triggered by Manganese-generated prion protein seeds. Journal of Neurochemistry. 120:177-189. Mancino A, Habbedine M, Johnson E, Luron L, Bebien M, Bajenoff M, Wu X, Karin M, Caamano, Seed MP, Lawrence T. (2013) I kappa B kinase (IKKα) activity is required for functional maturation of dendritic cells and acquired immunity to infection. EMBO J, advance online publication; doi:10.1038/emboj.2013.28. Watkins F, Pendry B, Sanchez-Medina A and Corcoran O (2012). Antimicrobial assays of three native British plants used in Anglo-Saxon medicine for wound healing formulations in 10th century England. Journal of Ethnopharmacology. 144:408-415.

Group Members

Ayoub (inflammation, pain and thermoregulation)

Casalotti (molecular neuroscience)

Corcoran (inflammation, wound-healing and lung cancer)

Morgan (toxicology of natural products and synthetic drugs)

Pendry (cancer and mental health)

Rahman (antimicrobial natural products)

Sanchez-Medina (pharmacology and phytochemistry of natural products)

Seed (preclinical models of inflammation and immunity)

Thompsett (neurodegenerative disease)

Torres (phytochemistry of Mexican flora)

Watkins (antimicrobial formulations from native British flora)

Webb (diet and nutrition)

uel.ac.uk/mrg

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Infection and Immunity Research Group (IIRG)


Research within the Infection and Immunity group explores the interactive role between the host immune response and patho-gen thereby elucidating mechanisms that may play a role in causing disease pathologies. Our multidisciplinary team provides a broad mixture of skills enabling us to synergistically deliver our research aims. Our group provides a forum supporting a broad range of related research areas recognised both nationally and internationally. This in turn has resulted in several fruitful col-laborative links with prestigious institutions around the globe. Through working as a research-oriented group, we provide a sci-entifically stimulating environment to enhance and benefit the experience of our post-graduate research students.

Our focus is primarily elucidation of the mechanisms that underpin the development of the immune system and the function of the immune response at both cellular and acellular levels

Investigation of potential virulence factors and other mechanisms utilised by pathogens compared to their less virulent environmental counterparts

Assessment of interactions between host and pathogens that might influence clinical consequences or likelihood of infection.

Grants

2013 UEL HSB Research Funding Initiatives: Functional analysis of the Role of Hedgehog signalling in B cell differen-

tiation £6934 [Outram]

2013 UEL School-Funded PhD studentship awarded 2013 [Cutler, Guiliano, Scotti]

2013 SfAM Students into work grant £2500 awarded April 2013 [Cutler].

Conference Presentations

Abdi, H. [Intern under supervision of Outram] “Sonic hedgehog regulates B cell development” ICH/UCL July 2012

Sirbu, E. [Intern under supervision of Outram] “Anti-microbial peptides regulate T cell function” ICH/UCL July 2012.

Invited Presentations

Cutler, S.J. “Unwanted holiday souvenirs – tropical zoonoses” ASM congress 16th-19th June 2012 San Francisco, USA

Cutler, S.J. “Bacterial zoonoses in a changing world – can we control these using “one health” initiatives?” 12th Sept 2012,

Onderspoort, South Africa

Cutler, S.J. “Emerging zoonoses in a changing world” Marseille Medical School 30th November 2012

Outram S ‘The role of morphogens in directing B cell development’ 4th July 2013 ICH/UCL .

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uel.ac.uk/iirg


Naddaf SR, Ghazinezhad B, Bahramali G, Cutler SJ. 2012 Phylogenetic analysis of the spirochete Borrelia microti, a potential agent of relapsing fever in Iran. J Clin Microbiol; 50; (9) 2873-2876.

Lau CI*, Outram SV*, Saldaña JI, Furmanski AL, Dessens JT, Crompton T.(2012)Regulation of murine normal and stress-induced erythropoiesis by Desert Hedgehog (Dhh). Blood. 17; 119 (20): 4741-51. * equal contribution

Pader, V., Nikitorowicz-Buniak, J. Abdissa, A., Adamu, H., Tolosa, T., Gashaw, A. Cutler, S.J. 2012 Rickettsia hoogstraalii in Ethio-pian Argas persicus ticks. Ticks & Tick-Borne Diseases 3: 337-344.

Haitham E, Gimenez G, Sokna C, Barker SC, Cutler SJ, Raoult D, Drancourt M. 2012 Multispacer sequence typing relapsing fever borreliae in Africa. PLoS Neglected Tropical Diseases; 6: e1652. Doi:10.1371/journalpntd.0011652.

Haitham E, Henry M, Diatta G, Sokna C, Socolovschi C, Cutler S, Mediannikov O, Raoult D, Drancourt M. (2013) Multiplex real-time PCR diagnostic of relapsing fevers in Africa. PLoS Neglected Trop Diseases 10.1371/journal.pntd.0002042.

Group Members

Sally Cutler Stefano Casalotti John George

David Guiliano Sue Outram David Rowley

Claudio Scotti Nadia Terrazzini Andrew Thompsett

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Neurorehabilitation Unit (NRU)


Our vision is to employ state-of-the-art assistive technology to enhance recovery of functional movement, intricate sensory aware-ness and communicative skills following stroke and traumatic brain injury. The main thrust of our work involves using adaptive ro-botics and advanced neuroimaging technologies and we have built an innovative hub for their development in the NRU. Together they offer an exciting insight into how clinical interventions impact on brain function. Clinical Trials in Stroke Rehabilitation

The NRU has a mission to enhance the quality of life and potential of community members who live with central nervous system injury (CNS) by undertaking clinical trials. Such interventions can be designed for use early after brain injury [e.g. acute and subacute stages of recovery after stroke or traumatic brain injury] or once the brain has recovered function somewhat [e.g. several years after of stroke]. We will be recruiting to a robot-therapy trial after stroke and this trial will be available through the NHS stroke units involved. Impacts, Grants & Collaborations

EU COST Action TD1006 "European network for robots in rehabilitation" [2011-2016; 0.5M euros].

NIHR “Robot-assisted therapy for the upper limb after stroke” [2014-2018; £3.1M].

News Items

We have, with neurosurgeons, recently pioneered the use of non-invasive brain stimulation to alleviate previously intractable chronic neuropathic pain. By first localising the position of most effective cortical stimulation through the scalp, it was possible to fully implant an epidural stimulator unit. We think this protocol will work significantly better than if the stimulator was implanted with no prior localization procedure. This non-invasive pre-operative localization procedure has enabled better reduction of chronic pain after limb amputation where a common symptom is phantom limb pain. Conference & Invited Talks

35th National Society of Physical Medicine and Rehabilitation, Romania

Centre for Sensory-Motor Interaction, Aalborg University, Denmark

International Congress for Neurorehabilitation, Switzerland


Turner DL, Kmetova M & Winterbotham W. (2012) Robot-assisted motor rehabilitation for complex upper limb impairments fol-lowing childhood stroke. Journal of Neurological Research 2, 65-68. Turner DL, Tang X, Kmetova M & Winterbotham W (2012) Recovery of submaximal upper limb force production is correlated with better arm position control and motor impairment early after a stroke. Clin. Neurophysiology 123, 183-192. Hunter T, Sacco P & Turner DL (2011) Changes in excitability of the motor cortex associated with internal model formation during intrinsic visuomotor learning in the upper arm. J. Behavioral and Brain Science 1, 140-152.

Unit Director

Prof Duncan Turner, Professor of Restorative Neuroscience and Rehabilitation

uel.ac.uk/nru

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Research within the group is grounded in applied sport and exercise sciences with expertise and interest in sport and exercise physiology, psychology and elite level competitive performance. In addition, the group benefits from specific expertise in the area of disability sport. The group's research aims to focus on how sport and physical activity impact on social, psychological and physiological outcomes. This work is further defined by specific expertise in assessing the determinants of, and patterns in, physi-cal activity rates in BME groups. The group employs a range of methodological approaches encompassing qualitative and quantita-tive methods. The group has recently begun to investigate psychophysiological responses to sport and physical activity, corporate social responsibility in professional sport and the impact of nutritional supplementation on sports performance.


Gilbert, K. (2012). Keynote Presentation – Sport & Development, 4th International Conference on Sport and Society, Cambridge University, 22-24th July 2012.

Gilbert, K. (2012). Keynote Presentation - Corporate Social Responsibility, 16th International Scientific Congress ‘Olympic Sport for All’ 17th – 19th May 2012 Sophia, Bulgaria.

Bottoms, L. (2013). The placebo and nocebo effects of a 'brand new sports drink' on peak minute power during incremental arm crank ergometry. American College of Sports Medicine (ACSM), Boston; Massachusetts, US.

News Items

The ASSRG has substantially increased its peer reviewed research output over the period 2011-12. In addition, through the contin-ued work of Keith Gilbert the group has a presence on national and international boards which serves to strengthen our external profile. We have welcomed one additional PhD student this year at the same time as progressing one current student to the point of completion. ASSRG members have successfully worked with individuals situated in other research groups (Medicines Research Group) and Schools (School of Psychology) in order to increase and diversify our work. It is our intention to consolidate these links over the course of the coming year.


Gilbert, K. & W. Bennett (2012). (Eds.) Sport, Peace & Development, Commonground Publishing, Champaign, Illinois.

Schantz, O.J. & K. Gilbert (2012). (Eds.) Heroes or Zero's: The Media’s Portrayal of Paralympic Sport, Commonground Publishing, Champaign, Illinois.

Solomon, G. S. & Buscombe, R. (2012). Expectancy Effects in Coaching. In Potrac, Gilbert and Denison (Eds.) Handbook of Sports Coaching. Routledge.

Buscombe, R. & Greenlees, I. (2012). ‘The role of time pressure and accountability in moderating the impact of expectancies on judgements of tennis performance’. International Journal of Sport Psychology, 43(4), 346-363.

Greenhalgh, A., Bottoms, L., and Sinclair, J. (2012). 'Tibial shock measured during the fencing lunge: The Influence of Surface'. Journal of Applied Biomechanics, Aug 22 (E Pub Ahead of Print).

Bottoms, L., Taylor, K., Sinclair, J., Polman, R., and Fewtrell, D. (2012) 'The effects of carbohydrate ingestion on the badminton serve following fatiguing exercise.' Journal of Sports Science, 30(3):285-293.

Group Members

Dr Richard Buscombe Dr Lindsay Bottoms Dr Marcia Wilson

Dr Symeon Dagkas Professor Keith Gilbert Kim Hastings

Nadia Grubnic Professor Stephen Edwards* Dr David Edwards*

Applied Sport Sciences Research Group (ASSRG)

uel.ac.uk/assrg

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The learning and teaching research group engages in pedagogical research and evaluation of learning, teaching and assessment methodologies. The group encompasses members from a diverse background of specialties, and aims to work in conjunction with learning and teaching research groups in other Schools of the University.

To experiment on a new mode of operation the Learning and Teaching Research Group in the year 2012-13 has operated within the Learning and Teaching Committee. At least 30 min of each committee meting has been dedicated to discussion pedagogic re-search. Other staff members are invited to this part of the meeting

Three main area of interests are

the use of e-technologies and particularly virtual world environments in the enhancement of learning and teaching. Recent lines of research include:

virtual laboratories and virtual patients

text messaging in classroom interaction

situated learning and teaching in clinical practice

the development of methodologies and technologies to facilitate large class practical teaching

electronic assessment, including the development and employment of electronic rubrics.

Group News

Grants: two personal HEA grants (ca. £6500 each) were awarded to Claire Deguid to carry out a comparative evaluation of the virtual world applications Second Life and Open Simm and to Stefano Casalotti to develop and evaluate a methodology of involv-ing senior students as markers using turnitin technology

Presentations

Heaney, R., Vannet, C. and Duguid, C. A Virtual Clinic in Second Life for Podiatry Students from Plymouth and East London 7th Plymouth Enhanced Learning Conference (PELeCON) 18-20 April, 2012, Plymouth, UK

Heaney, R. and Olasoji, R. A ‘low tech’ approach to management of Second Life Virtual Patients 2nd Global Conference: Experiential Learning in Virtual Worlds, March 2012, Prague, Czech Republic

Calvin Moorley and S.Casalotti : Peer Review: flexibility or prescription? UEL learning and teaching conference October 2012 .

Group Members

Karen Atkinson

Joy Needham

Julian Hargreaves

Jo Dawes

Learning and Teaching Research Group

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Further Information about Health, Sport & Bioscience: School Website: uel.ac.uk/hsb/ School Research Pages: uel.ac.uk/hsb/research/ Information for Prospective Postgraduate Students: uel.ac.uk/postgraduate/

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