1.RESEARCHMISCONDUCTDr. Priya Bhave Chittawar

2. The lazy persons guide to research?In a world of publish or perish is there a medicineto help us Rise to the occasion Perform research and publish it Fast track work Get personal and professional acclaimINSTANTLY! 3. A pill for every woe 4. What is the evidence on Laigra?How Many Scientists Fabricate and Falsify Research?A Systematic Review and Meta-Analysis of Survey DataDaniele Fanelli ( Plos 2009)*21 studies*Scientists admitting misconduct( falsification andfabrication) : 1.97% (95%CI: 0.864.45)*Other misconduct ( QRP): 33%*Scientists observing misconduct: 14%(CI: 9.9119.72)*Observing QRP: 28.53%, (CI:18.8538.2) 5. Research Misconduct What? Who? Why? How to prevent? How to detect? 6. Types Falsification Fabrication Plagiarism 7. How fraud affects us? Breast cancer treatment Cardioprotective diet Red wine and the heart 8. 1. Breast cancer treatment NSBAP project Mastectomy versus lumpectomy in treatment of Ca breast Life-table estimates five and eight years after surgery indicated that 90 percent of women who underwent lumpectomy followed by breast irradiation remained free of cancer in the ipsilateral breast. The rates of disease- free survival, survival free of disease at distant sites, and overall survival were not significantly different from those among patients who underwent either total mastectomy or lumpectomy alone. 9. NSBAP trial Major misconduct by one of the contributors Dr. Poisson(Montreal) Ineligible patients recruited, data fudged and altered tosuit the results. Office of research integrity( ORI) 10. 11. Findings did not change after excluding thecohort of patients from St Luc Hospital Cast a shadow on the findings. No longer powered to detect a clinicallysignificant difference 12. The Story of RamBMJ, 1992 Apr 18;304(6833):1015-9.Randomised controlled trial of cardioprotectivediet in patients with recent acute myocardialinfarction: results of one year follow up.Singh RB, Rastogi SS, Verma R,Laxmi B,SinghR,Ghosh S,Niaz MA.Medical Hospital and ResearchCentre, Moradabad, India. 13. Cont. 550 patients of myocardial infarction One year of low fat, high fibre diet Half risk of death due to all causes Cited 225 times Still on the Pubmed 14. If something is too good to be true, it is probablynot. 15. The Expose`BMJ. 2005 July 30; 331(7511): 281288.Suspected research fraud: difficulties of getting atthe truthCaroline White, freelance medical journalist1When research misconduct is suspected and theresearcher is working outside the jurisdiction ofofficial research bodies, there is nowhere foreditors to turn. If they want to investigate theirconcerns, they are invariably forced to go italonea lengthy, costly, and difficult process 16. Dr. Ram B.Singh First author on 28 full articles between 1989 and 1993, Five large intervention trials within the space of 18 months BMJ, AJC , Lancet, IJC and other high impact journals Who should carry out the research? ICMR 17. The best succumb Chamberlain: transposition of an ectopicpregnancy to the uterus. Andrew Weikfield: MMR vaccine with autism Scott Reuben: Pain management Dr. Anil Potti: genomics in chemotherapy 18. How fraud affects us? Breast cancer treatment Cardioprotective diet Red wine and the heart 19. Responsibility of authors Duplication Guest/gift authorship Keep raw data Conflict of interest Ethical considerations 20. Responsibility of Institutions INVESTIGATE RETRACT PREVENT STEP DOWN 21. COLLEAGUES 22. JOURNALS Retract Expression of concern Corrections 23. Research: 24. Dont just do it, Do it right! 25. The Lazy persons guide to research 26. Thankyou!