Introduction to Research Protocol for Pharmaceutical and Medicinal Chemistry Research

Department of Pharmaceutical ChemistryAnnamacharya College of Pharmacy

New Boyanapalli, Rajampet - 516126

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ByM. Nagendra Babu

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IDENTIFICATION OF PROBLEM

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Problem

Disease

Target

Toxicities of Drugs

Drug Resistance

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LITERATURE

Journals/Books/Articles/Scientific Magazines

Patents

Reports

Debates by Pharma. Industries during Conferences

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AIM & OBJECTIVES

Lead Identification and Optimization

Synthesis of Optimized Derivatives

Characterization of Synthesized Derivatives

Biological Screening

To Synthesize Novel Derivatives of

Therapeutic Potential

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RESEARCH PROTOCOL

Selection of Lead

Optimization of Lead

Synthesis of Optimized Structural Analogs

Characterization of Synthesized Analogs

Biological Screening

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SELECTION OF LEAD

Lead

Pharmacophore

Pharmacophore

Pharmacophore

Pharmacophore

N

NH

O

NH2

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OPTIMIZATION OF LEAD

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SYNTHESIS OF OPTIMIZED STRUCTURAL ANALOGS

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CHARACTERIZATION OF SYNTHESIZED ANALOGS

IR• Identification of functional groups

NMR

• Identification of number & nature of protons

• Identification of number of carbons

Mass• Identification of molecular mass

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BIOLOGICAL SCREENING

In-vitro AssaysToxicity Assays

In-vitro & in-vivoEx-vivo Assays In-vivo Assays

B i o l o g i c a l s c r e e n i n g M e t h o d s

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