rhBMP-2 Release from Injectable Poly(DL-Lactic-co-glycolic Acid)/Calcium-Phosphate Cement Composites

by P. Quinten Ruhe, Elizabeth L. Hedberg, Nestor Torio Padron, Paul H.M. Spauwen, John A. Jansen, and Antonios G. Mikos

J Bone Joint Surg AmVolume 85(suppl 3):75-81

August 1, 2003

©2003 by The Journal of Bone and Joint Surgery, Inc.

Scanning electron microscopy image of PLGA microparticles, showing the spherical shape of the microparticles.

P. Quinten Ruhe et al. J Bone Joint Surg Am 2003;85:75-81

©2003 by The Journal of Bone and Joint Surgery, Inc.

Microcomputed tomography image of 30:70 by weight PLGA/calcium-phosphate cement composite.

P. Quinten Ruhe et al. J Bone Joint Surg Am 2003;85:75-81

©2003 by The Journal of Bone and Joint Surgery, Inc.

Scanning electron microscopy image of 30:70 by weight PLGA/calcium-phosphate cement composite.

P. Quinten Ruhe et al. J Bone Joint Surg Am 2003;85:75-81

©2003 by The Journal of Bone and Joint Surgery, Inc.

Results of mechanical testing of calcium phosphate cement (Ca-P) and PLGA/calcium-phosphate cement composite.

P. Quinten Ruhe et al. J Bone Joint Surg Am 2003;85:75-81

©2003 by The Journal of Bone and Joint Surgery, Inc.

Results of LIVE/DEAD cytotoxicity assay of calcium phosphate cement (Ca-P).

P. Quinten Ruhe et al. J Bone Joint Surg Am 2003;85:75-81

©2003 by The Journal of Bone and Joint Surgery, Inc.

In vitro release of rhBMP-2-loaded PLGA microparticles and PLGA/calcium-phosphate cement composite in pH 7.4 and pH 4.0 under continuous shaking at 37°C, expressed as the ratio of total

cumulative mass of rhBMP-2 released to total mass of rhBMP-2 entrapped.

P. Quinten Ruhe et al. J Bone Joint Surg Am 2003;85:75-81

©2003 by The Journal of Bone and Joint Surgery, Inc.