ro cornell 12

Cornell University 2.12.11

Revised 12/07

AMERICAN COLLEGE OF VETERINARY RADIOLOGY

RECOGNIZED VETERINARY SPECIALTY OF RADIATION ONCOLOGY (ACVR-RO)

RESIDENCY TRAINING PROGRAM RE-ACCREDITATION APPLICATION NOTE: Some questions in this form are included for data collection purposes. The inclusion of an item does not necessarily imply that the item is a program requirement for ACVR-RO residency program. Please refer to the current Radiation Oncology Training Program Guidelines for comprehensive residency training requirements. This document may be downloaded from Members Only Downloads section of the ACVR website at http://www.acvr.org. APPLICATION INSTRUCTIONS: Training program directors wishing to have their programs evaluated should submit this electronic form and appropriate attachments electronically to the Chair of the Residency Standards and Evaluation Committee (RSEC) and to the Assistant Executive Director of the ACVR. The application must be received by February 15 of the third year following initial program approval / last re-accreditation The RSEC will evaluate the application, a vote will be taken, and the results of the vote and the majority recommendation of the committee forwarded to the President of the Recognized Veterinary Specialty for consideration at Executive Council at one of the two annual meetings. For the required ACVR and ACVIM Diplomates providing consultation in medical oncology and imaging, that are new to the program, please provide a brief 2-page curriculum vitae and specify the number of weeks each year that the individual will be available to actively support the radiation oncology resident. ACVR-RO RESIDENCY STANDARD TRAINING PROGRAM REACCREDITATION APPLICATION

1. Date of Application

2/12/11 Date of Initial Program Approval

2002

Cornell University 2.12.11 Date of Last Re-accreditation

2. Program Director(s): (Must be a Diplomate of ACVR Recognized Veterinary Specialty of Radiation Oncology)

Margaret C. McEntee

Program Director’s Contact Information:

Work Phone: 607-253-3208

Fax: 607-253-3055

E-mail: [email protected]

3. Additional ACVR-RO Diplomates supporting the program (not Program Directors)

None

Numbers of weeks per year an ACVR-RO Diplomate is available to resident on a daily basis.

48

4. Do you have a radiation oncology resident in training at this time?

5. Name of resident(s)

Michele Keyerleber

Is/are the resident(s) in an approved Standard program or an Alternative program:

February 2008

Yes No X


Standard Alternative Yes

6. Dates of training program (Please list only those dates of the actual training program. Time spent by the resident at your facility prior to beginning or following the completion of the actual training program should not be included.)

Dates of training program for resident (1) (mm/dd/yy)

07/13/09 – 07/24/11

Dates of training program for resident (2) (mm/dd/yy)

n/a


7. Location of Primary Institution Primary Site:

Cornell University, College of Veterinary Medicine Department

Department of Clinical Sciences Hospital/University

Cornell University Hospital for Animals Address

Dept. of Clinical Sciences, CVM, Cornell University City, State Zip Country

Ithaca, NY 14853 USA

8. Cooperating Institution(s) (If applicable): Roswell Park Cancer Institute

Department Radiation Medicine

Hospital/University Roswell Park Cancer Institute

Address Elm & Carlton Streets

City, State, Zip, Country

Buffalo, New York 14263 USA For cooperating institutions, attach letters of agreement signed on behalf of the

institution(s) by appropriate individual(s).

9. Length of Training Program (months):

24


If greater than 2 years, will this period include 24 months of continuous training in radiation oncology?

10. Number of months dedicated solely to radiation oncology training (excluding time on Medical Oncology service, Radiology/Imaging, etc.)

18

11. Advanced Degree:

Yes No Optional

Masters: X PhD: X

12. Essential Program Faculty: individual faculty member may serve in only one capacity

Please list all qualified faculty in support of program

a. Diagnostic Radiologist(s): (Must be Diplomate(s) of the ACVR)

Nathan Dykes, Peter Scrivani, Margret Thompson

Number of weeks per year an ACVR – Radiology diplomate is available to resident on a daily basis.

50

Faculty member on site?

Yes No X

Yes No


If off site, please explain relationship.

n/a


b. Medical Oncologist(s): (must be Diplomate(s) of ACVIM, Specialty of

Oncology)

Kelly Hume

Number of weeks per year an ACVIM-Oncology Diplomate is available to resident on a

daily basis.

50


Yes No X

If off site, please explain relationship

n/a

c. Surgeon(s): (must be Diplomate(s) of the ACVS)

H. Jay Harvey, James Flanders, Rory Todhunter, Ursula Krotscheck

Number of weeks per year an ACVS faculty member is available to resident on a daily

basis.

50


Yes No


X


n/a

d. Pathologist(s): (must be Diplomate(s) of the ACVP)

Sean McDonough, Donald Schlafer, Gerald Duhamel, Elizabeth Buckles, Jeanine Peters-Kennedy, Teresa Southard, Tracy Stokol (clin path), Deanna Schaefer (clin path)

Number of weeks per year an ACVP faculty member is available to resident on a daily

basis.

50


Yes No X



Please list all additional board certified specialists in direct support of the program. If offsite, please explain relationship.

Name Certifying College / Board

Luis Campoy

ACVA

Robin Gleed

ACVA

John Ludders

ACVA

Andrea Looney

ACVA

Sydney Moise

ACVIM/cardiology

Marc Kraus

ACVIM/cardiology

Bruce Kornreich

ACVIM/cardiology

Curtis Dewey

ACVIM/neurology

Sofia Cerda-Gonzalez

ACVIM/neurology

Nita Irby

ACVO

Thomas Kern

ACVO

Eric Ledbetter ACVO

Stephen Barr ACVIM/internal medicine

Sharon Center ACVIM/internal medicine

Richard Goldstein ACVIM/internal medicine

William Hornbuckle ACVIM/internal medicine

John Randolph ACVIM/internal medicine

Kenneth Simpson ACVIM/internal medicine

Daniel Fletcher ACVECC

Catherine Rogers ACVECC

Gretchen Schoeffler ACVECC


William Miller ACVD

Danny Scott ACVD

James K. Morrisey ABVP (avian)

Ricardo de Matos ABVP (avian)

Jennifer Rawlinson Dentistry

Joseph Wakshlag ACVN

13. How does resident receive training in Medical Oncology? What is time allotted for this training. Please provide description of formal and informal training experiences?

14. How is resident trained in diagnostic imaging? What is time allotted for this training. Please provide description of formal and informal training experiences?

One month rotation on the radiology service with responsibility to generate reports on imaging studies. Routine evaluation and review of all imaging studies performed on radiation therapy patients, as well as medical oncology patients. Films are routinely reviewed during the Friday morning rounds and on a daily basis during afternoon ward rounds.

2 one month rotations through the medical oncology section. On medical oncology rotation will receive new cases, see rechecks and be involved in the evaluation and treatment of both medical and radiation oncology cases. Will participate in twice daily rounds on the oncology service to discuss current cases. Medical and radiation oncology function as one service at Cornell University and there is daily discussions between the two specialties and shared responsibility for the patients.


15. How is resident trained in radiation biology? Please provide description of formal and

informal training experiences?

Radiation biology course.

16. How is resident trained in cancer biology? Please provide description of formal and informal training experiences?

Through topic reviews and journal club articles in Monday morning rounds. Additionally opportunities arise routinely in the clinical arena during the evaluation, and management of cancer patients.

17. How is resident trained in radiation oncology physics? Please provide description of

formal and informal training experiences?

Radiation physics course provided by radiation physicists from Roswell Park Cancer Institute.

18. Please list any formal courses and their instructors included in the residency training

curriculum. Please attach syllabi and instructor credentials for each listed course.

1. Radiation biology course, Margaret McEntee, DACVR(RO) 2. Radiation physics course, Medical physicists from Roswell Park Cancer Institute (Matthew Podgorsak, PhD, Prof., Radiation Oncology Physics)


19. Does the resident participate in clinical rounds on a daily basis while on clinical

rotations? Is a supervising Diplomate available for the majority of rounds? If no, please describe how rounds are attended and supervised.

Yes No X

Comments:

20. Are formal conferences, such as clinicopathologic conferences, journal clubs, or seminars held on a weekly basis?

Yes No X

Comments:

21. Please provide a description of the conferences, etc., that are provided and the typical schedule.

1. Journal club – combination of journal club and topic review rounds which are held every Monday morning 8-9 AM with presentations given by medical and radiation oncology residents and faculty. 2. Tumor board rounds – combined rounds with pathology, radiology, surgery and oncology to address different tumor types presented by faculty and/or residents in the three specialties held once a month on Friday morning from 8-9AM. 3. Morbidity/mortality rounds – held once weekly includes participation of residents and faculty in oncology to discuss current challenging cases. 4. Cardiology rounds – optional, held sometimes once weekly. 5. Anesthesia lecture series – topics presented by anesthesia residents and faculty on a weekly basis. 6. Chart rounds – weekly review of radiation records and port films for current patients. 7. Histopathology rounds – pathology residents and faculty present current surgical biopsies to clinicians on a daily basis which includes seeing the slides and discussion of the findings and diagnosis.


8. Radiology rounds – each morning to review cases from the previous day; attended when possible and when rotating through radiology. 9. Clinical pathology rounds – 1-2 times per month with review of the cytology from recent clinical cases in the hospital presented by the clinical pathologists. 10. Surgical oncology journal club – held once a month in conjunction with the surgical faculty and residents to review topics.


22. Is the resident required to give one or more formal presentations at a conference or in an educational setting on a yearly basis? If yes, please describe these conferences or educational settings.

Yes No X

Comments: Options include but are not limited to lectures given at Cornell University to interns/residents/students/faculty, presentations at ACVR, VCS, or ACVIM annual conferences

23. How many major veterinary medical or medical meetings is each resident able to or expected to attend during his/her training program? Please list the meetings attended.

None One Two > Two

X Comments: Options include but are not limited to ACVR annual conference, VCS

meeting, ASTRO

24. Does the training program require a research project? Please indicate the number of research projects required.

Yes No Optional Number X 1

Comments:

25. Are one or more publications required as part of the training program?

Yes No Number X 1

Comments:


26. Please indicate the availability of the following facilities or equipment. Indicate if these are available at the primary training site, or at a different location. For facilities that are not on-site, please describe the situation and availability in the space at the end of this section.

Available? On-Site? Equipment / Service Yes No Yes No Megavoltage Teletherapy Machine Please specify manufacturer and model: Siemens 6 MV linac with 5-14 MeV electrons, and MLC

X X

3D - Computer based treatment planning system Please specify manufacturer and model: Philips Pinnacle3

X X

2D/2.5 D - Computer based treatment planning system Please specify manufacturer and model:

X N/A

LDR Brachytherapy treatment and planning X N/A

HDR Brachytherapy treatment and planning X N/A

Diagnostic Radiology / Imaging Services X X

Conventional Radiography X X

Fluoroscopy X X

Ultrasound X X

Nuclear Medicine X X

Computed Tomography – Toshiba 16 slice multislice X X

Magnetic Resonance Imaging – 1.5 T MRI X X

Positron Emission Tomography X N/A

Intensive Care Facility - 24 hours X X

Clinical Pathology capabilities: (includes CBC, serum chemistries, blood gases, urinalysis, cytology, parasitology, microbiology,and endocrinology)

X X

Veterinary Library w/Literature Searching Capabilities X X


Medical Library w/Literature Searching Capabilities

X X

27. If any of the above equipment or facilities are available off-site, please explain how the

resident can access them for case management, research, or study.

Cornell Weill Medical is in NYC but electronic access available for collection.

28. Please list numbers of patients treated in the last 12 months using the listed radiation treatment modalities.

Modality Number Treated

Megavoltage Gamma / X-ray Teletherapy 50

LDR Brachytherapy 0

HDR Brachytherapy 0

Injectable Radionuclide therapy

Radioiodine Done through radiology (50)

Other (please specify) 0

90Strontium Pleisotherapy 5

Other - please specify N/A


29. Describe procedures for resident record recording of radiation treatment details of all

patients.

A detailed record is compiled for each radiation patient including: detailed treatment chart to record daily treatments by field, hand calculations on all computer plans, daily progress notes, medical history summarized by resident, physical examination performed by resident, diode measurements recorded, anesthesia record (by technicians), and record includes copies of blood work, imaging reports, histopathology reports, etc. A complete paper record is maintained for each patient and each patient is entered into the computer database.

30. What procedures are in place to facilitate collection of follow up information of patients

treated?

Computer database of radiation patients tracks routine recheck times. If a patient does not return to Cornell for routine rechecks then phone calls are placed by the radiation resident, and/or radiation oncology technicians to the owner and/or referring veterinarian to obtain follow up.

31. By what mechanisms and how often are residents evaluated? Please attach form used in

this evaluation (required).

Residents are evaluated by the 3rd and 4th year veterinary students that rotate through the oncology service and provided with a summary of the evaluations every 6 months. These evaluations are done electronically. Residents are evaluated by the medical and radiation oncology faculty every 6 months (see attached form) and a formal review of their performance and progress is provided in a meeting between the resident and the radiation oncology program director.


32. Please list the residents who have completed the training program including the year that each individual’s training program ended. If at all possible, please provide an address, and any information you have on the status of each individual with respect to the board certification process.

John Farrelly completed residency in 2004 and passed the certifying exam in 2004. Current address is as follows: Head, Radiation Therapy

The Animal Medical Center

510 East 62nd Street

New York, NY 10021

Blaise Burke completed residency in 2004/2005 and passed the certifying exam in 2005 Current address is as follows Veterinary Specialty Hospital 10435 Sorrento Valley Road San Diego, CA 92121 Tracy Gieger completed residency in 2007 and passed the certifying exam in 2007 Assistant Professor at Louisiana State University, School of Veterinary Medicine Skip Bertram Drive Baton Rouge, LA 70803

33. Please list any additional information of interest in support of this residency

re-accreditation application.

NYS Diagnostic Laboratory on site. DNA bank and active program. Currently have an internal cancer biology training grant with intent to apply for an NIH funded training grant.


Attachments: Please attach the following documents to the application if applicable. Please mark box to indicate which documents are included. Please list any additional documents attached in support of this application. Attached? Documents

YES Twenty-four (24) month calendar of resident’s activities - Required

YES CV - ACVR-RO Diplomate - Program Director(s) - Required N/A

ividuals CV - ACVR-R Diplomate(s) - Required

YES (new) CV - ACVIM-O Diplomate(s) - Required YES Syllabi of formal course work included in the training program - Required

YES (CV) Credentials of instructors providing formal course work - Required YES Forms used in resident evaluation - Required YES Letters of agreement from cooperating institutions - Required


Radiation Oncology Residency Calendar

July Aug Sept Oct Nov Dec Jan Feb Mar April May June MO RO RO RO Rad RO* RO RO RO RO Anes* RO MO RO RO RO RO RO* RO RO RO RO RO Study

MO – medical oncology (2 months total): Responsible for receiving both medical and radiation oncology patients that present for evaluation (diagnostics to include blood work, imaging, biopsy, etc.) and therapy, and to see recheck appointments with an emphasis on the radiation oncology patients that present for rechecks. Participate in twice daily ward rounds to discuss current patients. Attend and also routinely responsible for morning teaching rounds with 3rd and 4th year veterinary students that are rotating through the oncology service. RO – radiation oncology (18 months total): To consult on all potential radiation therapy patients that present to oncology or present to other services in the hospital. Develop a diagnostic and therapeutic plan. Review all imaging studies and the medical record for radiation patients. Perform a physical examination on all radiation patients prior to initiation of a course of radiation therapy. Position patients (vac-lok) for CT imaging for radiation treatment planning. Radiation treatment planning both CT based computer assisted 3D radiation treatment planning and manual planning. Involved in the daily treatment of radiation patients including assisting with anesthesia, patient positioning and delivery of radiation therapy. Telephone consultations with referring veterinarians on potential radiation patients. Rad – radiology (1 month total): To attend daily radiology rounds, observe image acquisition, and image interpretation under the guidance of the radiology residents and faculty. To generate imaging reports to be reviewed by the radiology faculty. Anes – anesthesia (2 weeks total): Anesthetize small animal patients under the direction of the anesthesia service. Participate in the daily anesthesia rounds while on the anesthesia service. Also, to attend anesthesia lecture series when possible and for relevant topics on anesthetics and management of patients under anesthesia. Study – (1 month total): To be spent preparing for the radiation oncology certifying examination. * For each of these one month blocks half of the time is to be spent on the designated service and the other two weeks are for vacation (10 days total each year) and two weeks optional for work on a project or time on another service such as pathology or clinical pathology.


RADIATION BIOLOGY Topics to be covered

Radiation chemistry Cellular responses to DNA damage Survival curves Sublethal damage repair, potentially lethal damage repair Linear energy transfer Relative biological effectiveness Radiation-induced cell cycle effects and age response through the cell cycle Mutagenesis, transformation and carcinogenesis The oxygen effect and reoxygenation Radiosensitizers, and radioprotectors Normal and tumor cell kinetics Early and late effects 4 R’s of radiotherapy Radiation and chemotherapy interactions Dose rate and dose fractionation effects Hyperthermia Miscellaneous topics


RADIATION PHYSICS Topics to be covered

Atomic and nuclear structure Radioactive decay Properties and production of particulate and electromagnetic radiation Interactions of electromagnetic radiation with matter Interactions of particulate radiation with matter Quantification and measurement of dose Characteristics of photon beams Dosimetry of photon beams in a homogenous water phantom Dosimetry of photon beams in a patient Dosimetry of electron beams Brachytherapy Radiation protection Other topics


Radiation Oncology Resident Evaluation Cornell University

Resident Name ______________________________ Evaluator(s) _________________________________________ Period covered by this evaluation ________________________ Year of program : 1 1 2 1

CATEGORY 1 2 3 4 NA CLINICAL ABILITY

Knowledge (theory/principle, current literature) Application of knowledge, logic Quality of patient management (diagnosis, treatment, follow-up) Patient care Diagnostic/technical skills Instructional skill Oral and written presentation Other

SENSE OF RESPONSIBILITY Initiative, motivation Judgement Reliability Organization Attendance at rounds and seminars Punctuality Other

INTERPERSONAL SKILLS Communication with :

Clients Faculty Students Technical and administrative staff Referring veterinarians Other house officers

Performance under stress Receptiveness toward guidance Other

HOSPITAL POLICIES AND PROCEDURES Medical records, including reports (timeliness, accuracy, completeness) Procedures (anesthesia scheduling, admissions/discharge) Other

STUDENT EVALUATION OF PERFORMANCE PROGRESS ON RESIDENCY AND BOARD REQUIREMENTS OVERALL EVALUATION

1 – frequently exceeds expectations/standards 2 – fully achieves expectations/standards 3 – needs improvement

Cornell University 2.12.11 4 – fails to achieve expectations/standards NA = not applicable Residents are expected to achieve a “fully achieves expectations/standards” in each category. For categories with a “frequently exceeds standards” score, residents should be acknowledged and commended. Suggestions for improvement with a reasonable time frame should be addressed for categories with a “needs improvement” or “fails to achieve expectations/standards” score. There should be evidence of improvement at the time of the next evaluation. If an overall score of “fails to achieve expectations/standards” is given at any time, a review of the resident is required to determine whether the resident will continue in his/her program. Written comments by faculty: Written summary of student evaluations: I have read and understand this evaluation. Signed, Resident ______________________________________ Advisor _______________________________________ Date __________________________________________

BIOGRAPHICAL SKETCH Provide the following information for the key personnel and other significant contributors in the order listed on Form Page 2.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME Margaret C. McEntee eRA COMMONS USER NAME (credential, e.g., agency login) MCMCENTEE

POSITION TITLE Professor of Oncology Department Chair, Dept. of Clinical Sciences

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)

INSTITUTION AND LOCATION DEGREE (if applicable) YEAR(s) FIELD OF STUDY

Cornell University, Ithaca, New York DVM 06/86 Veterinary Medicine North Carolina State University, Raleigh, NC Internship 07/86-06/87 Rotating Internship North Carolina State University, Raleigh, NC North Carolina State University, Raleigh, NC

Residency Residency

07/89-06/91 07/91-06/93

Medical Oncology Radiation Oncology

A. Positions and Honors

Positions and Employment: 1994-1997 Staff Oncologist, Animal Medical Center, New York, New York 1997-2000 2000-2008

Assistant Clinical Professor, University of California Davis, School of Veterinary Medicine Associate Professor, Cornell University, College of Veterinary Medicine, and Co-Director of the Sprecher Institute for Comparative Cancer Research (2005-present)

2008-present 2010-present

Professor, Cornell University, College of Veterinary Medicine Interim Chair, Department of Clinical Sciences, Cornell University, College of Veterinary Medicine

Honors and Professional Service:

1978 Phi Beta Kappa (University of Vermont) 2000-2002 President, American College of Veterinary Radiology, Radiation Oncology Affiliate 2006 Phi Zeta, Alpha Chapter, Cornell University

American College of Veterinary Internal Medicine – board certified in medical oncology (1993) American College of Veterinary Radiology – board certified in radiation oncology (1994) American Society for Radiation Oncology, member American Society of Clinical Oncology, member B. Selected peer-reviewed publications 1. McEntee MC, Silverman JA, Rassnick K, Zgola M, Chan AO, Tau PT, Page RL. Enhanced bioavailability

of oral docetaxel by co-administration of cyclosporine A in dogs and rats. Vet Comp Oncol 2003;1:105-112.

2. McEntee MC, Page RL, Theon AP, et al. Malignant tumor formation in dogs previously irradiated for acanthomatous epulis. Vet Rad Ultrasound 2004;45:357-361.

3. McEntee MC, Rassnick KM, Lewis LD, Zgola M, Page RL. Phase I and pharmacokinetic evaluation of oral docetaxel and cyclosporine in tumor-bearing dogs. Am J Vet Res 2006;67:1057-1062.

4. McEntee MC, Rassnick KM, Bailey DB, Balkman CE, Flanagan JL, Beaulieu BB, Zgola MM, Lewis LD, Page RL. Phase I and pharmacokinetic evaluation of the combination of orally administered docetaxel and cyclosporine A in tumor-bearing cats. J Vet Intern Med 2006;20(6):1370-1375.

5. Turrel JM, McEntee MC, Erb HN, Burke BP, Page RL. 131I treatment for advanced thyroid tumors: a retrospective study of 39 dogs (1990-2003). J Am Vet Med Assoc 2006;229:542-548.

6. Kim Y, Selvaraj V, McEntee MC, Travis AJ. Recipient preparation and mixed germ cell isolation for spermatogonial stem cell transplantation in domestic cats. Journal of Andrology 2006;27:248-256.

7. Turrel JT, Farrelly J, Page RL, McEntee MC. Strontium-90 irradiation for feline cutaneous mast cell tumors: a retrospective study of 35 cats (1992-2002). J Am Vet Med Assoc 2006;228:898-901.

8. McEntee MC. Portal radiography in veterinary radiation oncology: options and considerations. Vet Radiol Ultrasound 2008;49(1) Suppl 1:S57-S61.

9. McEntee MC, Steffey M, Dykes NL. Potential utility of surgical hemoclips in radiation treatment planning. Vet Radiol Ultrasound 2008;49:395-399.

10. Kim Y, Turner D, Nelson J, Dobrinski I, McEntee MC, Travis AJ. Production of donor-derived sperm after spermatogonial stem cell transplantation in the dog. Reproduction 2008;136:823-831.

11. Wakshlag JJ, Balkman CE, Morgan SK, McEntee MC. Evaluation of the protective effects of all-trans-astaxanthan on canine osteosarcoma cell lines. Am J Vet Res 2010;71:89-96.

12. Webster JD, Dennis MM, Dervisis N, Heller J, Bacon NJ, Bergman PJ, Bienzle D, Cassali G, Castagnaro M, Cullen J, Esplin DG, Pena L, Goldschmidt MH, Hahn KA, Henry CJ, Hellmen E, Karnstock D, Kirpensteijn J, Kitchell BE, Amorim RL, Lenz SD, Lipscomb TP, McEntee M, McGill LD, McKnight CA, McManus PM, Moore AS, Moore PF, Moroff SD, Nakayama H, Northrup NC, Sarli G, Scase T, Sorenmo K, Schulman FY, Shoieb AM, Smedley RC, Spangler WL, Teske E, Thamm DH, Valli VE, Vernau W, van Euler H, Withro SJ, Weisbrode SE, Yager J, Kiupel M. Recommended guidelines for the conduct and evaluation of prognostic studies in veterinary oncology. Vet Pathol 2010 Jul 27 [Epub ahead of print].

13. Stein R, Balkman C, Chen S, Rassnick K, McEntee M, Page R, Goldenberg DM. Evaluation of anti-human leukocyte antigen-DR monoclonal antibody therapy in spontaneous canine lymphoma. Leukemia and Lymphoma, 2010, in press.

BIOGRAPHICAL SKETCH DO NOT EXCEED TWO PAGES

NAME Hume, Kelly R.

POSITION TITLE Instructor, Section of Oncology Department of Clinical Sciences

EDUCATION/TRAINING: Begin with undergraduate BA/BS or equivalent. Include postdoctoral training (internship/residency/fellowship, etc.)


University of Wisconsin-Madison, Madison WI BS with Highest

Distinction 1995-1999 Animal Science

Auburn University, Auburn AL DVM cum laude 1999-2003 Veterinary Medicine

University of Georgia, Athens GA 2003-2004 Rotating Intern (Small Animal Medicine and

Surgery)

University of Georgia, Athens GA 2004-2005 Specialty Intern (Oncology)

North Carolina State University, Raleigh NC 2005-2008 Resident in Medical Oncology

Cornell University, Ithaca NY 2008-2010 Clinical Fellow, Biomedical Sciences

A. Certification

2008 – Diplomate of the American College of Veterinary Internal Medicine, Specialty of Oncology

B. Positions and Honors

Positions and Employment 2010-present – Instructor, Department of Clinical Sciences, College of Veterinary Medicine, Cornell

University Other Experience and Professional Memberships

2010 Reviewer, Journal of Feline Medicine and Surgery 2010-present Cornell University Comparative Cancer Biology Training Program 2009-present New York Academy of Sciences 2008-present American College of Veterinary Internal Medicine

Veterinary Cooperative Oncology Group 2004-present Veterinary Cancer Society 2003-2005 American Veterinary Medical Association 2004 Comparative Oncology Program – University of Georgia 2003-2004 American Association of Feline Practitioners

Academic and Professional Honors 2009 Cornell University-Pfizer Sponsored Attendee, Clinician Scientist Training Workshop,

University of Wisconsin-Madison 2003 Excellence in Feline Medicine and Surgery, AAFP Senior Student Award, College of

Veterinary Medicine, Auburn University 2002 Community Involvement Award, College of Veterinary Medicine, Auburn University

C. Selected Peer-reviewed Publications

Pavlova IP, Hume KR, Yazinski SA, Peters RM, Weiss RS, Webb WW. Multiphoton microscopy as a diagnostic imaging modality for lung cancer. Proc Soc Photo Opt Instrum Eng 2010;7569:756918.

Northrup NC, Gieger TL, Kosarek CE, Saba CF, LeRoy BE, Wall TM, Hume KR,

Childress MO, Keys DA. Mechlorethamine, procarbazine and prednisone for the treatment of resistant lymphoma in dogs. Veterinary and Comparative Oncology 2009;7:38-44.

Hume KR, Johnson JL, Williams LE. Adverse effects of concurrent carboplatin

chemotherapy and radiation therapy in dogs. Journal of Veterinary Internal Medicine 2009;23:24-30.

BIOGRAPHICAL SKETCH DO NOT EXCEED TWO PAGES

NAME Nathan L. Dykes

POSITION TITLE Senior Lecturer in Radiology Department of Clinical Sciences

EDUCATION/TRAINING: Begin with undergraduate BA/BS or equivalent. Include postdoctoral training (internship/residency/fellowship, etc.)


Rutgers University; New Brunswick, NJ BS 1966-70 Animal Science Cornell University; Ithaca, NY DVM 1970-74 Veterinary Medicine Rowley Memorial Animal Hosp.; Springfield, MA Internship 1974-75 Small Animal Med/Surg University of Pennsylvania; Philadelphia, PA Resident 1986-89 Radiology

A. Certification American College of Veterinary Radiology, 1991


Positions and Employment

2006-present Senior Lecturer, Radiology, Department of Clinical Sciences, College of Veterinary

Medicine, Cornell University, Ithaca, NY 1996-2006 Lecturer, Radiology, Department of Clinical Sciences, College of Veterinary Medicine,

Cornell University, Ithaca, NY 1991-96 Assistant Professor, Radiology, College of Veterinary Medicine, Cornell University, Ithaca,

NY 1989-91 Lecturer, Radiology, School of Veterinary Medicine, Philadelphia, PA

1986-89 Resident, Radiology, University of Pennsylvania, School of Veterinary Medicine, Philadelphia, PA

1984-86 Linden Heights Animal Hospital, Winchester, VA Small Animal Practice 1981-84 Loudoun Veterinary Service, Inc. Purcellville, VA Small Animal Practice 1976-81 Rowley Memorial Animal Hospital, Springfield, MA - Staff Surgeon 1975-76 Millar Animal Hospital, Deal, NJ Staff Veterinarian Other Experience and Professional Memberships

American Veterinary Medical Association American Animal Hospital Association American College of Veterinary Radiology New York Veterinary Medical Association Radiological Society of North America Society for Digital Imaging

Academic and Professional Honors 1970 Rutgers University, Graduation with Honors 1994 Yearbook Dedication, Class of 1994, College of Veterinary Medicine, Cornell

1994 Faculty Mentor Award, Multi-ethnic Student Veterinary Association, Class of 1994, College of Veterinary Medicine, Cornell

1994 Norden Distinguished Teacher Award, College of Veterinary Medicine, Cornell 2001 Distinguished Service Award, Southern Tier Veterinary Medical Association

C. Selected Peer-reviewed Publications

1. Clarifying some aspects of diagnostic-accuracy research. Scrivani PV, Dykes NL, Erb HN. Vet Radiol Ultrasound. 2004 Sep-Oct;45(5):419-23.

2. Effect of glomerular filtration rate on clearance and myelotoxicity of carboplatin in cats with tumors. Bailey DB, Rassnick KM, Erb HN, Dykes NL, Hoopes PJ, Page RL. Am J Vet Res. 2004 Nov;65(11):1502-7.

3. Association of the risk of development of hypothyroidism after iodine 131 treatment with the pretreatment pattern of sodium pertechnetate Tc 99m uptake in the thyroid gland in cats with hyperthyroidism: 165 cases (1990-2002). Nykamp SG, Dykes NL, Zarfoss MK, Scarlett JM.. J Am Vet Med Assoc. 2005 May 15;226(10):1671-5

4. Somatostatin receptor imaging in vivo by planar scintigraphy facilitates the diagnosis of canine insulinomas. Garden OA, Reubi JC, Dykes NL, Yeager AE, McDonough SP, Simpson KW. J Vet Intern Med. 2005 Mar-Apr;19(2):168-76.

5. Accuracy of increased thyroid activity during pertechnetate scintigraphy by subcutaneous injection for diagnosing hyperthyroidism in cats. Page RB, Scrivani PV, Dykes NL, Erb HN, Hobbs JM. Vet Radiol Ultrasound

6. Visually lossless compression of digitized radiographs based on contrast sensitivity and visual masking. Chandler DM, Dykes NL, Hemami SS,, Proc. Medical Imaging 2005, San Diego, CA, 2005.

7. Evaluation of serum iohexol clearance for use in predicting carboplatin clearance in cats. Bailey DB, Rassnick KM, Prey JD, Dykes NL. Am J Vet Res. 2009 Sep;70(9):1135-40.

8. Evaluation of quantitative trait loci for hip dysplasia in Labrador retrievers. Phavaphutanon J, Mateescu RG, Tsai KL, Schweitzer PA, Corey EE, Vernier-Singer MA, Williams AJ, Dykes NL, Murphy KE, Lust G, Todhunter RJ. Am J Vet Res. 2009 Sep;70(9):1094-101.

9. Estimation of heritabilities, genetic correlations and breeding values of four traits that collectively define hip dysplasia in dogs. Zhang Z, Zhu L, Sandler J, Freidenberg SS, Egelhoff J, Williams AJ, Dykes NL, Hornbuckle W, Krotscheck U, Moise NS, Lust G, Todhunter RJ. Am J Vet Res. 2009 Apr;70 (4):483-92.

Section A and B should not exceed two pages: A. Positions and Honors Positions and Employment: 1993-1994 Veterinarian, Liverpool Veterinary Hospital, Liverpool, NY 1994-1997 Radiology Residency, Ohio State University, College of Veterinary Medicine 1997-1998 Instructor, Cornell University College of Veterinary Medicine 1998-2005 Lecturer, Cornell University College of Veterinary Medicine 2005-present Assistant Professor, Cornell University College of Veterinary Medicine Other Experience and Professional Memberships: 1990-present American Veterinary Medical Association 1994-present American College of Veterinary Radiology 1998-present New York State Veterinary Medical Society 2000-present Phi Zeta, Alpha Chapter 2001-present World Association of Veterinary Anatomists 2006-present ACVR CT/MRI Society Honors: 1996, 1997 Clinical Teaching Excellence Award, Pfizer Animal Health and Ohio State University 1997 Service Award, Ohio State University B. Selected peer-reviewed publications (last 3 years only)

1. Freer SR, Scrivani PV. Post-‐operative susceptibility artifact during magnetic resonance imaging of the vertebral column in two dogs and a cat. Vet Radiol Ultrasound 2008;49(1):30-‐34.

2. Gold JR, Divers TJ, Miller AJ, Scrivani PV, Perkins GA, Van Biervliet J, deLahunta A. Cervical vertebral spinal hematomas in 4 horses. J Vet Intern Med 2008;22(2):481-‐485.

3. Burns GO, Scrivani PV, Thompson MS, Erb HN. Relation between age, body weight and medial retropharyngeal lymph node size in apparently healthy dogs. Vet Radiol Ultrasound 2008;49(3):277-‐281.

4. Winegardner KR, Scrivani PV, Gleed RD. Lung expansion in the diagnosis of lung disease. Compendium Contin Educ Vet 2008;30(9):479-‐489.

5. Pownder S, Scrivani PV. Non-‐selective computed tomography angiography of a vascular ring anomaly in a dog. J Vet Cardiol 2008;10(2):125-‐128.

BIOGRAPHICAL SKETCH Provide the following information for the key personnel in the order listed for Form Page 2.

Follow this format for each person. DO NOT EXCEED FOUR PAGES.

NAME POSITION TITLE

Scrivani, Peter Vincent Assistant Professor of Veterinary Imaging EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


Cornell University D.V.M. 1993 Veterinary Medicine

6. Cerda-‐Gonzalez S, Dewey CW, Scrivani PV, Kline K. Imaging features of atlanto-‐occipital overlapping in dogs. Vet Radiol Ultrasound 2009;50(3):264-‐268.

7. Scrivani PV, Freer SR, Dewey CW, Cerda-‐Gonzalez S. Cerebrospinal fluid signal-‐void sign in dogs. Vet Radiol Ultrasound 2009;50(3):269-‐275.

8. Dewey CW, Scrivani PV, Krotscheck U, Cerda-‐Gonzalez S, Bailey KS, Marino DJ. Intracranial arachnoid cysts in dogs. Compendium Contin Educ Vet 2009;31(4):160-‐168.

9. Freer SR, Scrivani PV, Erb HN. Associations between cardiopulmonary variables and the cerebrospinal fluid signal-‐void sign in small-‐breed dogs. Vet Radiol Ultrasound 2009;50(4):360-‐363.

10. Dewey CW, Cerda-‐Gonzalez S, Scrivani PV, Looney AL. Surgical stabilization of a craniocervical junction abnormality with atlanto-‐occipital overlapping in a dog. Compendium Contin Educ Vet 2009;31(10):E1-‐E6.

11. Dawson DR, Scrivani PV, Schaefer DMW, Bogdanovic LB, Ainsworth DM. Epitheliod variant of hemangiosarcoma in a gelding. Equine Veterinary Education 2009;21(10):519-‐524.

12. Pownder SL, Scrivani PV, Bezuidenhout A, Divers DJ, Ducharme NG. Computed tomography of temporal bone fractures and temporal region anatomy in horses. J Vet Intern Med 2010;24:398-‐406.

13. Levine JM, Scrivani PV, Divers TJ, Furr M, Mayhew IJ, Reed S, Levine GJ, Foreman JH, Boudreau C, Credillle BC, Tennent-‐Brown B, Cohen ND. Multicenter case-‐control study of signalment, diagnostic features and outcome associated with cervical vertebral malformation-‐malarticulation in horses. J Am Vet Med Assoc 2010;237(7):812-‐822.

14. Scrivani PV, Levine JM, Holmes NL, Furr M, Divers TJ, Cohen HD. Observer agreement study of cervical-‐vertebral ratios in horses. Equine Vet J, DOI: 10.1111/j.2042-‐3306.2010.00300.x

15. Sharma A, Thompson MS, Scrivani PV, Dykes NL, Yeager AE, Freer SR, Erb HN. Comparison of radiography and ultrasonography for diagnosing small-‐intestinal mechanical obstruction in vomiting dogs. Vet Radiol Ultrasound, DOI: 10.1111/j.1740-‐8261.2010.01791.x

BIOGRAPHICAL SKETCH DO NOT EXCEED TWO PAGES.

NAME Margret Sara Thompson

POSITION TITLE Lecturer, Imaging

EDUCATION/TRAINING (Begin with baccalaureate or other initial professional education, such as nursing, and include postdoctoral training.)


Smith College, Northampton, MA A.B. 1985-89 Architecture Boston University, Boston, MA M.Ed. 1992-93 Counseling Psychology Tufts University, N. Grafton, MA D.V.M. 1994-98 Veterinary Medicine Angell Memorial Animal Hospital, Boston, MA Internship 1998-99 Rotating Internship University of Florida, Gainesville, FL Residency 1999-2002 Veterinary Radiology

A. Certification – American College of Veterinary Radiology- board certified in radiology (2002)


Positions and Employment: 2002-2006 Clinical Assistant Professor, University of Florida, College of Veterinary Medicine, Gainesville,FL 2004-2006 Section Chief-Imaging, University of Florida, College of Veterinary Medicine, Gainesville,FL 2006-current Lecturer, Cornell University, College of Veterinary Medicine, Ithaca, NY 2010-current Section Chief-Imaging, Cornell University, College of Veterinary Medicine, Ithaca, NY Other Experience and Professional Memberships: American College of Veterinary Radiology American Veterinary Medical Association Academic and Professional Honors University of Florida, Health Science Center Superior Accomplishment Award – Digital Radiography Project 2004 University of Florida, College of Veterinary Medicine

1st Annual SACS Departmental Service Award 2004 Support Services Resident of the Year 2001 Support Services Resident of the Year 2002 11th Annual Resident Seminar of the Year, Winner 2002 10th Annual Resident Seminar of the Year, Co-Winner 2001 Tufts University, School of Veterinary Medicine Student

Pharmacia & Upjohn Small Animal Proficiency Award 1998 Eastman Kodak Radiology Achievement Award 1998 Phi Zeta Veterinary Honor Society Member 1998 NIH Student Research Competition - 2nd Place 1996

Dean's Commendation 1996 – 1998 C. Selected peer-reviewed publications Sharma A, Thompson MS, Scrivani PV, Dykes NL, Yeager AE, Freer SR, Erb HN. Comparison of Radiography and Ultrasonography of Small-Intestinal Mechanical Obstruction in Vomiting Dogs. Article first published online: 28 DEC 2010 | DOI: 10.1111/j.1740-8261.2010.01791.x Mulz JM, Kraus MS, Thompson MS, Flanders JA. Cranial vena caval syndrome secondary to central venous obstruction associated with a pacemaker lead in a dog. Journal of Veterinary Cardiology, 2010 Dec; 12 (3): 217-223.

Sharma A, Thompson MS, Schnabel LV, Mete A, Hackett R. Imaging Diagnosis-Equine Nasal Septal Thickening due to Chronic Chondritis. Vet Radiol Ultrasound, 2010 Jan-Feb: 51(1):65-8. Flanders JA, Thompson MS. Dyspnea caused by epiglottic retroversion in two dogs. J Am Vet Med Assoc. 2009 Dec 1; 235 (11): 1330-5. Hill RC, Ginn PE, Thompson MS, Seguin MA, Miller D, Taylor DP. Endobronchial polyp derived from a myxosarcoma in the lung of a dog J Am Anim Hosp Assoc. 2008 Nov-Dec:44 (6):327-34. Marolf A, Blaik M, Ackerman N, Watson E, Gibson N, Thompson M. Comparison of computed radiography and conventional radiography in detection of small volume pneumoperitoneum. Vet Radiol Ultrasound. 2008 May-Jun;49(3):227-32. Burns, GO, Scrivani PS, Thompson MS, Erb H. Relation between age, body weight, and medial retropharyngeal lymph node size in apparently healthy dogs. Vet Radiol Ultrasound. 2008 May-Jun;49(3):277- 81. Scrivani PV, Thompson MS, Winegardner K, Dewey C. Association between frontal-sinus size and syringohydromyelia in small-breed dogs: 62 cases (2004-2006). Am J Vet Res. 2007 Jun;68(6):610-3. Gardner A, Thompson MS, Heard D. Radiographic Evaluation of Cardiac Size in Flying Fox Species (Pteropus rodricensus, P. hypomelanus and P. vampyrus). J Zoo Wildl Med. 2007 Jun;38(2):192-200. Nelligan MR, Wheeler JL, Lewis DD, Thompson MS. Bilateral correction of metatarsal rotation in a dog using circular external skeletal fixation. Australian Veterinary Journal 2007 85(8) 332-336. Adin CA, Sereda CW, Thompson MS, Wheeler JL, Archer LL. Use of a percutaneously controlled hydraulic occluder in the treatment of canine intrahepatic shunts: short-term outcome in 10 dogs. J Am Vet Med Assoc. 229(11):1749-55, 2006. Marolf A, Specht A, Castleman W, Thompson MS. Radiographic and Urethrographic Findings associated with a Penile Hemangiosarcoma. Vet Radiol Ultrasound. 47(5) 474-475, 2006. Farese JP, Milner R, Thompson MS, et al. Stereotactic radiosurgery for the treatment of osteosarcomas involving the distal portions of the limbs in dogs. J Am Vet Med Assoc 225(10): 1572-87, 2005. Guille AE, Lewis DD, Anderson TP, Beaver DP, Carrera-Justiz SC, Thompson MS, et al. Evaluation of surgical repair of humeral condylar fractures using self-compressing Orthofix pins in 23 dogs. Vet Surg 33(4):314-22, 2004. Gunkel CI, Valverde A, Robertson SA, Thompson MS, et al. Treatment for a severe reaction to intravenous administration of diatrizoate in an anesthetized horse. J Am Vet Med Assoc 224(7):1143-6, 2004. Thompson MS, Graham JP, Mariani CL. Helical CT Angiography: Diagnosis of a Porto-Azygous Shunt. Vet Radiol Ultrasound 44(3):287-291, 2003. Dhar AK, Thompson MS, et al. Determination of cDNA Sequence and mRNA Expression of Interleukin 1 Receptor Antagonist in Horses. Am J Vet Res 67(8):920-4, 2000.


February 2011

CURRICULUM VITAE

MATTHEW B. PODGORSAK, PHD, FAAPM, DABMP Personal Information: Home Address: Work Address: Department of Radiation Medicine Roswell Park Cancer Institute Elm and Carlton Streets Buffalo, New York 14263 Tel.: Tel.: FAX: e-mail: Education: CEGEP: Marianopolis College, Montréal, Québec (1982-84) Major field: Health Sciences Undergraduate: McGill University, Montréal, Québec (1984-87) Major field: Physics Graduate: McGill University, Montréal, Québec (1987-89) Major field: Medical Physics University of Wisconsin, Madison, Wisconsin (1990-93) Major field: Medical Physics Degrees: D.E.C. (Health Sciences) Marianopolis College, Montréal (June 1984) B.Sc. (Hon. Physics) McGill University, Montréal (June 1987) M.Sc. (Physics) McGill University, Montréal (February 1990) Thesis: Fricke radiation dosimetry using NMR Ph.D. (Medical Physics) University of Wisconsin, Madison (December 1993) Thesis: Radiation parameters of high dose rate Iridium-192 sources Present Appointments: • September 1998 to present: Roswell Park Cancer Institute, Department of Radiation

Medicine: Chief Physicist. • December 1993 to present: State University of New York at Buffalo, Department of

Radiation Oncology: Clinical Assistant Professor. • September 1997 to present: Erie Community College, Department of Physics: Adjunct Clinical Professor.

Cornell University 2.12.11 • December 2002 to present: State University of New York at Buffalo, Department of

Molecular and Cellular Biophysics: Associate Professor. • March 2008 to present: State University of New York at Buffalo, Department of Physiology and Biophysics: Research Assistant Professor. Professional Certifications:

Diplomate, American Board of Medical Physics (ABMP), Certified in Radiation Oncology Physics, 1997, re-certified 2007. Diplomate, American Board of Radiology (ABR), Letter-of-Equivalence, Certified in Radiologic Physics, 2002.

Professional Affiliations: American Association of Physicists in Medicine (AAPM) (member since 1988). Canadian Organization of Medical Physicists (COMP) (member since 1990). Upstate New York Chapter of the AAPM (member since 1997). American College of Medical Physics (ACMP) (member since 2001). American Society for Therapeutic Radiology and Oncology (ASTRO) (member since 2008). Awards, Fellowships, and Honors: - Fellow, American Association of Physicists in Medicine (AAPM), 2009. Grant Funding: - Principal Investigator, “Image-guided tracking of tumor motion and its relation to PTV size,” National

Science Foundation (NSF) / University at Buffalo subaward, September 1, 2010 to August 31, 2011: $21,000.

Committee Memberships: - Radiation Safety Committee, Roswell Park Cancer Institute, 1997 – present - Quality Improvement Committee, Department of Radiation Medicine, Roswell Park Cancer Institute,

2001 – present. - Quality Assurance Committee, Department of Radiation Medicine, Roswell Park Cancer Institute, 2001

– present. - Continuing Education Committee, American College of Medical Physics (ACMP), January 2004 –

December 2007.

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