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ROAD TO CANCER:

MOLEKULER

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DASAR MOLEKULER

Kerusakan genetik non-letal: Karsinogenesis

Empat kelas gen regulator normal:

1. growth-promoting proto-oncogen (beta katenin),

2. growth-inhibiting tumor suppressor genes (p53), TSG:governor atau guardian

3. genes that regulate programmed cell death (Bcl2),

 . gene !ang terlibat dalam reparasi "#$ (%&'

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LES GENETK 

!eru"a#an genetik

$% Ke&il 'mutasi pa(a $ titik)insersi)(elesi*

+% ,esar se#inga mene"a"kan peru"a#an

karotpi&

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!ERU,A.AN KAR/OT/!C: TRANSLOK

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DELES

!OOR !ANCREATC CAN

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AM!L0KAS

NEURO,LAST

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ANEU!LOD 1 NOT MULT!LE O0 .A!LOD

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MCRORNA DAN CANCER

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KARSNOGENESS : MULTSTE!!ROCESS

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.ALLMARK O0 CANCER

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!ERAN CDK DAN CDK-N.,TOR DALAM SKLUSSEL

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