role of technologies in health innovations. raimo sepponen, aalto university
TRANSCRIPT
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Role of technologies in health innovations
Raimo Sepponen, professorAalto University
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Role of technologies in health innovations
• Case: Magnetic resonance imagingInvented by Paul Lauterbur and Peter Mansfield
• Early development stimulated by Raymond Damadian – claimed that malignant tissue may be diagnosed by measuring relaxation time T1
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Raymond Damadian's "Apparatus and method for detecting cancer in tissue."
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FONAR -MRI
One of the first whole body MR imagesAbout 1978, Fonar-method
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The first MR images in Germany
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Some early truths about MRI (~1980)
• The highest usable field strength for human studies is about 0.2 T
• MRI will not have any role in routine diagnostics
• Imaging times will always be long due to low S/N
• With MRI any contrast agents will not be needed or can be used
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But- magnets got stronger
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Optimum field?
• 0,15 T – Hammersmith hospital 1985• 0,35 T – University of San Francisco -1985• 1,5 T – General Electric 1986• 2,0 T – Siemens, Philips 1987• 3, 0 T - 2000• 7,0 T - 2015• 11,5 T - 2020
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First image
0,1 T field
0,17 T scanner at HUCS
0,02 T Acutscan0,04 T Magnaview0,1 T Mega40,1 T Merit
0,22 T Proviev
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1 Mmk
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OTC NYS250 Mmk
1st Patent
25 Patents
InstruTKKTEKES
InstruAkatemiaHYKS
1st Thesis
2nd Thesis
4 Thesis
Premarketapproval
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Open magnet technology – key for the success of MRI-units produced in Finland
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Multiple coils and SENSE Technology
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MRI Today
• Over 10 000 units world wide, routine clinical use
• Typical fieldstrength 1,5 T , 3,0 T increasing,7,0 T introduced
• Imaging times in the range ms/image• Over 20 different contrast agents available,
more under development
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Architecture of human white matter connectivity (Danielle Bassett)
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• Not all problems have a technological answer, but when they do, that is the more lasting solution.
• Andy Groveone of the founders of Intel Corporation