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Brain Aging University of California, Irvine

Institute for Brain Aging & Dementia Volume 4, Issue 2

BulletinC O N T E N T S

Brain Aging is the newsletter

of the Institute for Brain

Aging & Dementia, a non-

profit Institute dedicated to

improving the lives of those

afflicted with Alzheimer’s

disease through research and

education.

S U M M E R 2 0 0 3

“Conference” Continued on Page 3

2003 Regional Alzheimer’s Disease ConferenceResearch and Caregiving: The Best of Both Worlds

Faculty Spotlight:Frank LaFerla, Ph.D. 7

Clinical Trials 9Memory WalkHighlights 8

Donors 10

What’s New at theInstitute 2

Calendar 12

Dr. Carl Cotman and Dr. Guy McKhanndiscuss ways to

“Keep Your Brain Young”

The UCI Institute for Brain Aging andDementia and the Alzheimer’s Associat-ion of Orange County held its firstcollaborative two-day RegionalAlzheimer’s Disease ResearchConference on May 8-9, 2003 at theNewport Beach Marriott. The excitingtwo-day conference combined UCI’sspring “Beckman” Conference and theAlzheimer’s Association of OrangeCounty’s “Facing the Challenge”Conference. An outstanding roster ofdistinguished speakers and researcherspresented new research information,state-of-the-art caregiver issues, and themost current findings in the race to findthe cause, treatment, and cure of thisdisease. Attendance for this conferencewas outstanding, with over 470participants and a large number ofsponsors and exhibitors. TheConference received extensive localnews coverage and very enthusiasticcompliments from those in attendance.When the attendees were polled, manyof the responses were very positive,“Great conference! Good balance ofscientific and practical information!”

This year’s theme for the conferencewas “Behavior: Measurement, Inter-vention, and Consequences”. The goalof the conference was to examine newbehavioral and pharmacologicalstrategies for maintaining high cognitive

function during aging and to assist thosewith dementia to have a high quality oflife. The emphasis was placed on behav-ioral strategies, as this is an area wherebasic research is increasingly demon-strating that such strategies can stimulatethe benefits and optimization of drugeffectiveness.

Exercise can help maintain cognitivefunction and decrease brain atrophy

The conferencewas kicked off bykeynote speakerArthur Kramer,Ph.D., from theUniversity of Illi-nois. Dr. Kramerspoke on “Cogni-tive Vitality and

Aging” and how exercise can help main-tain cognitive function and decrease brainatrophy that can occur with normalaging. He presented brain imaging data

Keynote speaker,Arthur Kramer, M.D.

2003 Regional Alzheimer’sDisease Research andEducation ConferenceHighlights 1

Research NewsThe Making of theTransgenic Mouse 6

UCI Institute for Brain Aging & Dementia

Brain AgingUCI Institute for Brain Aging & Dementia

2

What’s New at the Institute?

Recently theUCI Institute forBrain Aging andDementia teamed upwith Adult DayServices of OrangeCounty to create a partnership andprovide clinical assessment services atthe Huntington Beach site. The programopened it’s doors to its first participantsin July of last year.

The new satellite clinic proves to bea success, drawing in persons ofdifferent ethnic backgrounds,particularly those of Hispanic andVietnamese descent. Neurological andNeuropsychological testing is availablein English, Spanish, and Vietnamese.Appointments can be scheduled bycalling the main clinic appointmentline at (949) 824-2382.

Community Partners: AdultDay Services of OrangeCounty

New Clinic for AgingResearch and EducationOpens Its Doors in LagunaWoods

Family Educational SeriesCalendar of Upcoming Events...2003 Family Educational SeriesCo-Sponsored by the UCI Institute for Brain Aging &Dementia, Alzheimer’s Association, and Adult Day Servicesof Orange County. All Sessions meet from 4:30-6:30pm atthe University Club, UCI Campus. Call (949) 824-2382 forreservations and details.

September 9- Research Advances: Are We Almost There Yet?December 9- Coping with Grief and Loss During the Holidays

“Coping at Home: A Survival Guide For Alzheimer’sFamilies”Co-Sponsored by the UCI Institute for Brain Aging &

Dementia, and the Alzheimer’s Association. All Sessions meet from 2:00-4:00pm at the University Club, UCI Campus. Call (949) 824-2382 forreservations and details.

August 7- Compassionate Communication With The Memory ImpairedAugust 14- Behavioral Challenges Associated with Alzheimer’s DiseaseAugust 21- In Times of Crisis: What You Should KnowAugust 28- Body Mechanics: Don’t Break Your Back

The Clinic for Aging Research andEducation (C.A.R.E.) hosted an OpenHouse on November 8, 2002. Alongwith munchies and drinks, handouts andsample apparatus tests were adminis-tered to visitors along with guided toursof the new facility. Door prizes for freemeals at the newly opened Home TownBuffet located in the same complexwere given away to two lucky winnersthat rainy day. The C.A.R.E. office is

the newest addition to the Institute forBrain Aging and Dementia at UCI.

The researchers at the C.A.R.E. officeare currently enrolling participants intothe 90+ Study, a new study for peoplewho are 90 years of age and older.These researchers, under the directionof Claudia Kawas M.D., plan to study

ways to maximize the potential of theoldest-old as they age.

To learn more about the 90+ Study,call 949-824-9121 to have a freeinformational brochure sent to you.

New UCIInstitute forBrain Agingand DementiaWebsite!

http:// www.alz.uci.edu*Sections of the new website maystill be under construction.Dr. John Ringman interviewing

a 90+ Study Participant


Brain Aging 3

“Conference” Continued from Page 1

“Conference” Continued on Page 4

Dr. Laura Mosqueda takes a moment to listen and talk toseveral caregivers at the conference

(MRI, magnetic resonance imaging) that demonstrated thosewho exercise and are fit have less age-related brain atrophy.

Elizabeth Head, Ph.D., from UC Irvine, expanded on Dr.Kramer’s talk, discussing “Antioxidants, CognitiveEnhancement, and Successful Aging”. Research from longi-tudinal studies with aged dogs suggests that modifications ofdiet and environmental variables can help to promotesuccessful aging. Dr. Head shared that through modifica-tions of the environment (i.e., diet, exercise, and education),and changing lifestyle choices, a person can promotesuccessful brain aging.

In addition tovaluable researchinformation pre-sented at theconference, theaudience had anopportunity tohear about curr-ent caregivingissues as well.David Troxel,

M.P.H, from the California Central Coast Alzheimer’sAssociation argued that behavioral interventions are anessential part in the management of dementia patients,activities, games, socialization, and exercise.

Behavioral interventions and pharmacologicalapproaches continue to be one of the gold standardsIn parallel with behavioral interventions, pharmacologicalapproaches continue to be one of the gold standards. MurrayRaskind, M.D., from the Seattle VA Medical Center, spokeabout the management of agitation and dementia and out-lined several strategies for the selection and utilization ofvarious new second-generation antipsychotic medications.He noted these drugs should be started at low dosages,increased very slowly, and the dosing should be stoppedwhen there is an improvement or if a side effect develops. Ifineffective over the dose range, another should be tried asthere are subtle but real response differences among thesecond-generation antipsythotics. He emphasized the

importance of the proper use of these drugs since they arethe mainstay of treatment for agitation and psychosis andusually effective.

Linda Teri, Ph.D., from theUniversity of Washington out-lined strategies to recognize andunderstand the behavioral prob-lems of dementia, learn how toproblem-solve associatedpatient problems, enhancesocial skills, maximize cognitivefunctions, and finally, how tolearn to admit to get help.

Laura Mosqueda, M.D., from UC Irvine, discussed medi-cal facts about behavioral problems and what we shouldand should not believe. She suggests that we, as medicalconsumers, families, and caregivers should try to learn asmuch medical information as possible, especially when itpertains directly to a current situation. She also suggeststhat as we are given information through various channels

(news, media, hypes, etc.), we should put the next promiseof a miracle cure/treatment into perspective. Think criticallyabout any information that you hear or read.

One of the dementias that has shown various behavioral

David Troxel, M.P.H. shares his expertisewith conference attendees

Dr. Linda Teri andDr. Carl Cotman




4

Dr. Kesslak talks to a conference attendee

Linda Scheck, of the Alzheimer’sAssociation, with members of the

Medical Scientific Advisory Board

problems is thatof Frontal Tem-poral Dementia(FTD), discussedby J. PatrickKesslak, Ph.D.,of UC Irvine. Dr.Kesslak wentinto depth aboutFTD, the courseof the disease, and some of the behavioral problems thatoccur amongst individuals who have been diagnosed withFTD.

A series of several informal roundtable sessions were held inseparate rooms for the audience to get an update on a rangeof topics. These were presented by members of theAlzheimer’s Association of Orange County’s MedicalScientific Advisory Board, bringing to the audience inform-ation on various dementia subtypes, medication management,as well as clinical/legal issues involved with dementia. Theinformal sessions provided a great forum for attendees tointeract with the speakers in a smaller setting. A Panel dis-cussion, made up from the roundtable session presenters,was then led by Dr. Raskind who helped to summarize thefindings and reports of each session. Several Caregiverroundtables were arranged for the second day of theconference and also provided the audience with an oppor-tunity to interact with those speakers, who discussed topicssuch as Elder Abuse, Health Insurance, Benefits ofStructured Activities, and other very helpful topics.

New training methods for healthcare workersBeverly Sanborn, L.C.S.W. Sanborn presented somealarming facts about the need for an increase in the numberof health care workers in the near future. She stated that inthe next five years, there will be a need for a 25% increase innursing assistance and a need for a 74% increase in homehealth aides! She predicted that by 2020, there would be aneed for 1.1 million more people in the nursing field! One ofthe biggest limitations, however, in this area is the recruiting,training, and maintenance of good staff. Sanborn suggestedtraining through observation by creative use of videos and

she demonstrated the use of specially developed robots thatare placed in assisted living facilities! She mentioned thatthese tools have tremendous potential for large companiesand multi-campus facilities, allowing them to save time andmoney by having higher-level staff coach front-line staff inan efficient and effective manner.

Living with Dementia: An Early-Stage PanelOne of the most engaging sessions of the conference, wasthe “Insights into Early Dementia Panel”, that was moder-ated by Cordula Dick-Muehlke, Ph.D., of Adult DayServices of Orange County. Within the panel, there werethree individuals, who had been diagnosed with MildCognitive Impairment, accompanied by their spouses, whohad graciously agreed to participate in a live paneldiscussion at the conference. They discussed real-lifesituations and the changes they have had to make to adaptto their current life problem. The panel put the practicalissues into perspective from a standpoint that is often notheard and at the time of closing the audience gave them astanding ovation.

Keeping your brain youngThe closing keynote speaker Guy McKhann, M.D., fromJohns HopkinsU n i v e r s i t ysummed up theconference. Dr.McKhann is mostrecently recog-nized for the bestseller book thathe co-authoredwi th Mar i lynAlbert, Ph.D.,“Keeping YourBrain Young:The CompleteGuide to Physical and Emotional Health and Long-evity”. Dr. McKhann summarized the current state ofresearch to improve health and how it is increasingly in-tegrated with basic science. He discussed how to keep yourmind active and stimulated in order to enhance cognitive


Brain Aging 5

Alzheimer’s Disease Research Centerof California

at theUCI Institute for Brain Aging & Dementia

1100 Gottschalk Medical PlazaIrvine, CA 92697-4285

website: www.alz.uci.eduFor information and appointments please call: (949) 824-2382

Sponsor/ExhibitorOpportunities for the

2004 Regional Alzheimer’sDisease Research

and EducationConference available!

Reserve your table today!For more information, call

(949) 824-8135

A special thankyou to all of

the 2003Regional

Alzheimer’s DiseaseResearch and EducationConference sponsors andexhibitors who helped tomake the conference a

success!


Arnold Starr, M.D.Chief NeurologistGaby Thai, M.D.

NeurologistMalcolm B. Dick, Ph.D.

NeuropsychologistPatrick Kesslak, Ph.D.

NeuropsychologistCordula Dick-Muehlke, Ph.D.

Clinical PsychologistShirley Sriyordsa

Education CoordinatorSwitaya Ken KrisnasmitPatient Care Coordinator

Rosa GoetteProgram Assistant

Claudia Kawas, M.D.Associate Director of Clinical Science

Carl W. Cotman, Ph.D.Program Director

Ruth Mulnard, R.N., D.N.Sc.Associate Director of Administration

Greg Whitman, M.D.Neurologist

John Ringman, M.D.Neurologist

Catherine Ortiz, R.N., M.S.N., G.N.P.Clinical Trials Coordinator

Beatriz YanezClinical Trials Recruitment Coordinator

Aleece NoujaimClinical Trials Recruitment CoordinatorHyunmie Kim, R.N., M.S.N., G.N.P.

Nurse PractitionerKaren Shore, R.N.,M.S.N., A.N.P.

Clinical CoordinatorLinda Nelson, Ph.D.

Successful Aging Coordinator

function, stressing the “If you don’t useit, you lose it!” theory. Dr. McKhannalso gave tips on what you can do to“Keep Your Brain Young”, such asphysical activities, mental activities, therole of nutrition, and things that one cando to help stimulate the mind. He alsogave some pointers on genetic risks,therapies (past, present, and future), andwhat can be expected in the area ofbrain aging research. He also led adiscussion with the conference co-chairand director of the UCI Institute forBrain Aging and Dementia, Dr. CarlCotman. This discussion allowed theaudience an opportunity to ask ques-tions and provided them a chance tolearn from one of the U.S.’s leadingneurologists!

This year’s conferencewas a tremendoussuccess and the UCIInstitute for BrainAging and Dementiaand the Alzheimer’sAssociation of OrangeCounty look for-ward to coordinatinganother exciting andinformative conferencenext Spring. If youwould like more infor-mation or would like tobe added to the mailing list to receiveinformation on upcoming educationalevents and the Regional Alzheimer’sDisease Research Conference in 2004,

please call (949) 824-2382 and ask tobe added to the mailing list. We hopethat you will be able to join us at nextyear’s conference, May 6-7th, 2004!

Conference attendees showed great enthusiasm andinterest for the various speakers and topics for the

2003 Conference



6

Faculty Spotlight: Frank M. LaFerla, Ph.D.The Making of the Transgenic Mouse

High magnification view of the hippocampus of atriple transgenic mouse showing ß-amyloid stainingin brown and tangles in blue. The arrows point toextracellular ß-amyloid deposits. Note that manycells manifest both pathologies (arrowheads).

Alzheimer’s disease is the most common form of dementiaworldwide, with the vast majority of Alzheimer’s disease casesoccurring sporadically in elderly individuals over 65-70 yearsof age. Some Alzheimer’s disease cases, however, are familialand transmitted from one generation to another. These familialAlzheimer’s disease cases generally develop at a much earlierage of onset compared to the sporadic version. For instance,some familial Alzheimer’s disease cases begin as early as 16years of age! Other than the age of onset, both forms arequite similar pathologically and clinically. At theneuropathological level, the Alzheimer’s disease brain ischaracterized by two hallmark lesions: amyloid plaques andneurofibrillary tangles. These two lesions occur in selectivebrain regions such as the temporal lobe. Plaques arecomprised of small proteins called ß-amyloid, whereas tanglesare comprised of biochemically modified form of the tauprotein. It is currently not clear what the relationship of thesetwo lesions are to the disease phenotype, although convergingevidence from multiple fields suggests that ß-amyloid maybe the trigger for all cases of Alzheimer’s disease.

To study the pathogenesis of Alzheimer’s disease, researchersturn to animal models such as the mice. These mouse modelsare useful because they are relatively cheap, easy to breedand maintain, and more importantly, because human genesare biologically functional even when expressed in commonlaboratory animals such as the mouse. These geneticallymodified mice are referred to as transgenic mice, becausethey contain foreign transferred genes.

The LaFerla lab has recently two important transgenic mousemodels. The first is an animal model of Alzheimer’s diseaseand the second is of a muscle disorder that is related toAlzheimer’s disease called inclusion body myositis.

Transgenic model of Alzheimer’s disease Although thefield has been able to model either plaques or tangles intransgenic mice, recapitulating both lesions in the same mousemodel in Alzheimer’s relevant brain regions has proven to bea difficult challenge. The LaFerla lab utilized a novel strategyfor developing a transgenic mouse that harbors three mutantAlzheimer’s related genes. Because of the strategy that they

employed, all three transgenes are inherited in everygeneration, which means that the mice breed as easily asany single transgenic mouse. In addition, all of their miceare on the same genetic background, thereby eliminating acritical confounding variable that typically is difficult to avoid.

LaFerla’s triple transgenic mice develop both plaques andtangles in a progressive and age-related manner (see picturebelow). The accumulation of these lesions also parallels thedistribution pattern that has been observed in the humanAlzheimer’s disease brain. Notably, the ß-amyloid plaquesdevelop several months prior to the development of the tanglepathology. This finding is consistent with the genetic evidencein human studies that show that ß-amyloid lies upstream oftangles in the neuropathological cascade. These tripletransgenic mice are particularly useful for testing potentialtherapeutic compounds and will allow investigators todetermine if clearing ß-amyloid deposits is sufficient toprevent or reverse the tangle pathology.

Transgenic model of inclusion body myositis Inclusionbody myositis is the most common muscle disease inindividuals over the age of 55. It is an incurable disorder that


Brain Aging 7

This figure compares the motor performance of normalmice and two transgenic lines: A2 and A6, which expressthe transgene to the low and high levels respectively,on the accelerating rotarod. Note that the controlsshow no substantial age-related deficit but that boththe A2 and A6 transgenic lines exhibit an age-relateddeficit beginning around 10 months.

Biography of Frank M. LaFerla, Ph.D.leads to severe disability. Like Alzheimer’s disease, inclusionbody myositis occurs sporadically or can be inherited. Mostcases of inclusion body myositis are sporadic, with anunknown etiology. Surprisingly, this muscle disorder hasmuch in common with Alzheimer’s disease. Althoughinclusion body myositis patients are not demented, theirmuscle fibers are characterized by the accumulation of many“dementia”-related proteins, most notably the ß-amyloidpeptide. Eventually the accumulation of these proteins inthe muscle fibers of these patients leads to their paralysis.

The role of ß-amyloid in the pathogenesis of inclusion bodymyositis is still unresolved. To develop a transgenic mousemodel of this common, age-related muscle disorder, weselectively targeted overexpression of the ß-amyloidprecursor protein to skeletal muscle through use of themuscle-specific gene promoter. We showed that theoverexpression of this Alzheimer’s related protein intransgenic mice led to the development of histopathologicaland clinical features characteristic of human inclusion bodymyositis, including motor deficits in aged-mice. One methodof studying the motor ability of mice is to place them on amotorized rotating well that is called the rotarod (see picturebelow). Healthy mice can remain on the rod for longerperiods of time than transgenic mice.

Frank M. LaFerla obtainedhis undergraduate degreefrom St. Joseph’s University(Philadelphia) in 1985 andhis doctorate from theUniversity of Minnesota(1990). He subsequentlycompleted his postdoctoraltraining at the HollandLaboratory of the AmericanRed Cross. There hebecame interested in the development andcharacterization of genetically-modified animalmodels of complex human neurologic disorderssuch as Alzheimer’s disease. In late 1995, he wasappointed as an assistant professor in theDepartment of Neurobiology and Behavior at theUniversity of California, Irvine. He became a tenuredassociate professor in 2000 and also serves as theassociate director for brain science for the Institutefor Brain Aging and Dementia. At UC Irvine, hislaboratory remains focused on dissecting the

neuropathogenesis ofAlzheimer’s disease. Hehas been well recognizedfor his research accom-plishments and has re-ceived several awards

including the Ruth Salta Investigator Award forAlzheimer’s Disease Research by the AmericanHealth Assistance Foundation (2000) and serves onthe Brain Disorders and Clinical NeurosciencesGrant Review Panel for the National Institutes ofHealth.

You can learn more about ProfessorLaFerla’s research on his webpage:

http://neurobiology.bio.uci.edu/faculty/laferla/

or by visiting the Institute for Brain Aging &Dementia website at: http://www.alz.uci.edu



8

Memory Walk 2002: Another Year to RememberThe UCI Institute for Brain Aging and Dementia Memory Walk Team

wins the “Largest Team” for the 7th consecutive year

UCI

“Orange” We the Largest Team?!The 2002 UCI Institute for Brain Aging and Dementia Memory Walk Team

We could not have done it without all of the participantsand dedicated efforts to help in the fightagainst this devastating disease! A huge“thank you” to everyone who has madelast year’s Memory Walk asuccess!

Children and adults of all ages attended last year’sRobinson’s May Alzheimer’s Association Memory Walk atthe Irvine Spectrum on October 5, 2002. Hosting the larg-est Memory Walk in the nation, with almost 5,000 partici-pants, Orange County raised over $550,000 for theAlzheimer’s Association of Orange County.

For the seventh consecutive year, the UCI Institute forBrain Aging and Dementia won the “Largest Memory WalkTeam”, thanks to the hundreds of walkers and “forget-me-nots” who participated with the UCI Memory Walk Team

2002! The UCI team recruited over 300walkers and raised over $10,000 in fundsthat will go towards helping a countlessnumber of families and patients throughthe Alzheimer’s Association.

A special thanks goes to Dr. DianeEdwards (Professor at the SaddlebackCollege Emeritus Institute), Milly Polash,and Maurice Labovich, who helped torecruit over 200 Leisure World Exer-cisers! Great Job!

Come Join the Fun in 2003!Mark your calendars for the 2003 Alzheimer’sAssociation Memory Walk!When: Saturday, October 4th, 2003Where: Irvine Spectrum

To receive information about the walk or joining theUCI Memory Walk Team, call (949) 824-2382.

THANKTHANKTHANKTHANKTHANKYYYYYOU!OU!OU!OU!OU!


Brain Aging 9

Specialized Educational SupportGroups for FTD & Lewy Body

Dementia CaregiversWe welcome all caregivers of patients with FrontalTemporal Dementia (e.g., Pick’s Disease and PrimaryProgressive Aphasia) and caregivers of those withLewy Body Dementia to our monthly supportgroups.

When? Meetings are held the first Wednesday of each month from9:30am-11:30am

Where? Meetings are held in the 1st floor conference room of theGillespie Neuroscience Research Facility on the UCI Campus

Co-Facilitators are Lynne Conger of the Alzheimer’s Associationand Shirley Sriyordsa of the UCI Institute for Brain Aging &

Dementia. For more information about the group,please call (949) 824-8135.

On the Forefront: An Update on Clinical Trials

Valproate Study for Alzheimer’s Disease♦ Double-blind 26-month study to test the ability of Valproate to prevent the occurrence of behavior problems in individuals with Alzheimer’s disease♦ For men and women 50 years of age or older who have been diagnosed with Alzheimer’s disease, and who have not experienced agitation and/or psychosis since the onset of their illness

Aricept Treatment Study for MildCognitive Impairment♦ Double-blind 1-year study of donepezil (Aricept) to treat mild cognitive impairment♦ Objective is to test the ability of Aricept to improve memory and/or delay the progression of the memory problem♦ For men and women 45 years of age or older who have a memory complaint recognized by an informant

Homocysteine Treatment Study for AD♦ Double-blind 18-month study of B-6, B-12, and Folic acid for delay of progression in Alzheimer’s disease (AD)♦ For men and women over the age of 55 who have been diagnosed with AD♦ Cannot currently be taking B-6, B-12, or Folic Acid supplements

Depression and Alzheimer’s Disease♦ Follow-up study for individuals with Alzheimer’s disease with and without depression; not a treatment study♦ For men and women who have AD; limited to patients seen at our assessment center; informant needed♦ A small fee is paid at each visit for partipation in this study

Statin Treatment Study for AD♦ Double-blind 21-month study of simvastatin for delay of progression in Alzheimer’s disease (AD)♦ For men and women over the age of 55 who have been diagnosed with AD♦ Cannot currently be taking cholesterol lowering medication

Current and Upcoming Clinical Study Options

For more information,please call Beatriz Yanez

or Aleece Noujaim at(949) 824-5733 or visit our

website at: http://www.alz.uci.edu/clinicaltrials/



DONORS

10

here are many ways tosupport the clinical and basicscience research activities atthe UCI Institute for BrainAging and Dementia. If youwould like to receive moreinformation on giving, pleasecontact Shirley Sriyordsa at(949) 824-8135.

University of California, IrvineInstitute for Brain Agingand Dementia

C linic forAgingR esearch &E ducation24361 El Toro Road, Ste. 150Laguna Woods, CA 92653(949) 768-3635email: [email protected]

Jean & Silvia BerchtoldCeleste CarneroMary Chahinian, Focus Technologies Inc.Steven C. GabrielCynthia GrimesGeorge & Marian JeromsonGladys LetinCarol G. McGillMelin Family Foundation Fund of the Orange County Community FoundationAristotle & Eleni MitchelThe New Majority Committee

Jack RosenbergJack A. & Ryna H. RothbergShirley SchwartzLeonard & Marian TorresThomas & Joyce Tucker, Community Foundation of the Jewish Federation of Orange CountyRuth F. Wolstoncroft

In Memory of Helen AllbrandtJohn B. & Charlyn W. Barton

In Memory of Vera BarrettHoyt F. & Dorothy M. Martin

In Memory of Kenneth BodineMartin B. Goldberg and Alan B.Lash, Lash & Goldberg LLP

In Memory of Patricia BodineCynthia GrimesBetty T. KulishJeanne & Larry Varnell

In Memory of E. CanterPaul R. & Jorja A. Puma

In Memory of Wilma J. DeanUCI College of Medicine –Educational Affairs

In Memory of Dr. L. De LeonITT IndustriesPatricia L. Samora

In Memory of William W.Drewry, Jr.Mary Louise DrewryR.W. & Mary Fay Rockwell

In Memory of Dorothy E. FolgnerLois Schwartz

In Memory of Herbert FreedEsther Freed

In Memory of Isaac J. GabrielVickie BeckerKenneth C. Bussey InvestmentsIrene V. CastonWilbur J. & Henrietta C. EichFlorentino & Regina GarzaRobert & Bernice GogoThomas M. & Phyllis M. HellwigMarie C. & Kathleen M.McCalmonRoberta L. McPetersBabette H. MeyersJ. Willard MonningerCharles D. ObershawPaper Partners, Inc.Porter Family TrustWayne & Marion Scott

A special thank you for all of thedonors who have contributed tothe UCI Institute for BrainAging and Dementia. Yourgenerous and thoughtful giftswill help to promote advancesin Brain Aging Research at theUniversity of California, Irvine.

Torrey Olins, Sage Hill SchoolR.W. & Marian Fay Rockwell

Field of Flowers- by Peggy

All artwork for this Donor section isfrom the 2002 Alzheimer’s Association

Memories in the Making program.C


Brain Aging 11

To make a donation to the UCI Institutefor Brain Aging, log on to:

http://www.alz.uci.edu/donate.htmlor call (949) 824-8135.

Make a Contribution, andMake a Contribution, andMake a Contribution, andMake a Contribution, andMake a Contribution, andHelp Make a DifferenceHelp Make a DifferenceHelp Make a DifferenceHelp Make a DifferenceHelp Make a Difference

1.) Checks should be made payable to:UCI Foundation UCI Foundation UCI Foundation UCI Foundation UCI Foundation and in the Memosection please write: Alzheimer’sAlzheimer’sAlzheimer’sAlzheimer’sAlzheimer’sR e s e a r c hR e s e a r c hR e s e a r c hR e s e a r c hR e s e a r c h2.) If the donation is being made inmemory/honor of someone, pleaseinclude a note with information as towhere the acknowledgements shouldbe sent to.3.) Please mail the donations to:

Institute for Brain Aging & Dementia1113 Gillespie Neuroscience Research Facility

Irvine, CA 92697-4540

Jack & Lila StricklerJuliet W. SwingJoe B. WinkelmannBeverly R. WoodDaniel J. & Mary Lee YoungLaw Offices of Fullerton, Lemann,Schaefer, & Dominick, LLPDainko & Wise LLP

In Memory of Marjorie GarrettHelmut & Lynda Cook

In Memory of Hal HagginsGail & Rene Rigaud

In Memory of MadelaineHolkeswickDorris Van Culin

In Memory of Adolphus JollySharon M. Spring

In Memory of Mabel KleinJohn W. & Suzanne L. ChandlerRoland & Mary HaasJack W. & Jean S. KleinRobert W. & Marjorie A. LichtsinnC. Alice Schwene

In Memory of MargeLuttenbackerGeorge & Martha DotyRobert & Nancy GaripayW.E. & Eleanor Hullinger Jr.Cynthia I. Tamkin

In Memory of Lillian MalucelliJudy O. Ayers

In Memory of Albert L. NicholsM.D.Bruce & Karen ClarkCathy A. Genard

Michael & Eleanor GordonRobert & Linda HoveeRichard C. HunsakerAmos Z. KrauszMichael O. & Judith A. KroppJerald C. & Beverly D. NelsonMaria NewLinda White PetersW.F. & P.J. PodlichArnold E. & Mary M. RiserFredric M. Roberts FoundationMary RooseveltErnie SnyderJared & Eva-Maria TausigGerard R. & Barbara A. Waldt

In Memory of Sue PiercePaul R. & Jorja A. Puma

In Memory of Jack W. RobertsMickey Roberts

In Memory of Arthur RoseHerbert & Cecelia Brody

In Memory of Richard RosolackLin Abel

In Memory of Veikko SiiraRonald J. Firestone

In Memory of Edward N. StuebingThe Maple Heights Board ofEducation Members and theAdministrative Staff

In Memory of Rose WarrenCharles L. & Laura A. Anglen

In Memory of Seymour LockeWattsMarcia J. McKinley

In Memory of W. Clarke WilkinVirginia D. AllhusenDr. Catheryn L. BoothMargaret BurchinalRoger & Martha CoxDr. Wendy A. Goldberg GilmoreKathleen McCartneyDeborah PhillipsSusan J. SpiekerDeborah Lowe Vandell

In Memory of James WoelkeLinda Scheck

In Memory of Ann WolczanskiMickey Roberts

Circus in Town- by Eugene

University of California, IrvineInstitute for Brain Aging & Dementia1113 Gillespie Neuroscience Research FacilityIrvine, CA 92697-4540

Non Profit Org.US PostagePAIDSanta Ana, CAPermit No. 1106


“The Old Bridge in the Fall” by BethArtwork borrowed from 2002 Orange County Alzheimer’s Association

Memories in the Making Calendar. The Calendar may be purchased by calling (714) 283-1111.

2003 Alzheimer’s Association

Memory Walk

To join the UCI team or for moreinformation, please call (949) 824-2382

Saturday, October 4th, 2003

Irvine Spectrum, Irvine

September 9September 9September 9September 9September 9Family Educational

Series WorkshopResearch Advances: AreWe Almost There Yet?

DecembeDecembeDecembeDecembeDecember 9r 9r 9r 9r 9Family Educational

Series WorkshopCoping with Grief and

Loss During the Holidays

AugustAugustAugustAugustAugust“Coping at Home: A

Survival Guide forAlzheimer Families”, A

4-Part SeriesThursday AfternoonsUniversity Club, UC Irvine

Sign-Up with theUCI Institute forBrain Aging Teamby September 12th

and receive a freeT-Shirt! Come andjoin the fun!

October 4October 4October 4October 4October 42003 Alzheimer’s Association

Memory WalkIrvine Spectrum

November 8November 8November 8November 8November 8What is Memory Loss?

Offered in SpanishAdult Day Services of

Orange County

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MaMaMaMaMay 6-7,y 6-7,y 6-7,y 6-7,y 6-7, 2004 2004 2004 2004 20042003 Regional Alzheimer’s

Disease Research andEducation Conference

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