ryan irvin, phd, ms · ryan irvin cv • january 2017 • 1 curriculum vitae ryan irvin, phd, ms...
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Ryan Irvin CV • January 2017 • 1
CURRICULUM VITAE
Ryan Irvin, PhD, MS
Office Address University of Alabama at Birmingham
Department of Epidemiology
1665 University Blvd, Room 220F
Birmingham, AL 35294-0022
Mailing Address RPHB 220F
1530 3rd Ave S
Birmingham, AL 35294-0022
Telephone 205.975.7672
Fax 205.934.8665
Email [email protected]
Web http://www.soph.uab.edu/faculty/epi/ryan_irvin
Education
2008 PhD Epidemiology, University of Alabama at Birmingham, Birmingham AL.
Dissertation: Genetic risk factors for type 2 diabetes with pharmacologic
intervention in African-American patients with schizophrenia or
schizoaffective disorder. Advisor: Rodney Go, [email protected]
2004 MS Biostatistics, Medical University of South Carolina, Charleston SC
1999 BS Biology with Honors, University of North Carolina, Chapel Hill, NC
Postdoctoral Training
2008 – 2011 Postdoctoral Fellow, joint appointment in Epidemiology and Section on Statistical
Genetics, University of Alabama at Birmingham, Birmingham AL.
Research Focus: Genomics and pharmacogenomics of cardiovascular disease.
Advisors: Donna K. Arnett, [email protected]; Hemant Tiwari, [email protected]
Faculty Appointment
2011 – 2017 Assistant Professor, Department of Epidemiology, University of Alabama at
Birmingham School of Public Health, Birmingham, AL
2017 – Associate Professor, Department of Epidemiology, University of Alabama at
Birmingham School of Public Health, Birmingham, AL
Additional Professional Appointments
2013 – Associate Scientist, Comprehensive Cardiovascular Center, University of Alabama
at Birmingham, Birmingham, AL
2013 – Associate Scientist, Nutrition Obesity Research Center, University of Alabama at
Birmingham, Birmingham, AL
2015 – Associate Scientist, Comprehensive Arthritis, Musculoskeletal, Bone and
Ryan Irvin CV • January 2017 • 2
Autoimmunity Center, University of Alabama at Birmingham, Birmingham, AL
Brief Chronology of Employment History
2004 – 2008 Project Manager and Multi-Site Coordinator, Department of Epidemiology,
University of Alabama at Birmingham. Supervisor: Rodney Go, [email protected]
2007 – 2008 PhD Candidate Research Assistant, Department of Biostatistics, University of
Alabama at Birmingham. Supervisor: Hemant Tiwari, [email protected]
2000 – 2004 Statistical and Research Analyst II, Department of Pulmonary and Critical Care
Medicine, Medical University of South Carolina. Supervisor: Charlie Strange,
1998 – 2000 Research Assistant, Department of Biology, University of North Carolina at
Chapel Hill. Supervisor: Bob Duronio, [email protected]
Summer 1999 Intern National Institute of Environmental Health Sciences, Research Triangle
Park, NC, Supervisor: Rick Paules, [email protected]
Professional Societies
2006 International Genetic Epidemiology Society
2009 Nominated Member of AAAS/Science Program for Excellence in Science
2011 – 2017 American Heart Association
Teaching
2017 – Course Co-Instructor, Analyzing Data and Publishing Findings in Large Cohort
Studies: REGARDS, BST 695
2015 – Course Instructor, Analysis of Case-Control Studies EPI 710
2011 Guest Lecturer Genetic Epidemiology EPI731 (2 sessions)
2012 Guest Lecturer Genetics in Public Health EPI635 (1 session)
2012 Guest Lecturer Graduate Biomedical Sciences GBS 721 (2 sessions)
2012 Guest Lecturer Cardiovascular Disease Epidemiology EPI606 (1 session)
2012 Guest Lecturer GBS 739-Neuropharmacology (1 session)
2012 Guest lecturer in Epidemiology Analysis of Follow-up Studies (720) (1 session)
2013 Guest Lecturer Graduate Biomedical Sciences GBS 721 (2 sessions)
2013 Guest Lecturer Methods Review in Epidemiology EPI781 (1 session)
2013 Guest Lecturer Pharmacoepidemiology EPI609 (1 session)
2013 Guest Lecturer Statistical Genetics BST775 (1 session)
2014 Guest Lecturer Genetic Epidemiology EPI 731 (1 session)
2015 Guest Lecturer Statistical Genetics BST775 (1 session)
2015 Guest Lecturer Genetics in Public Health EPI635 (1 session)
2015 Guest Lecturer Pharmacoepidemiology EPI609 (1 session)
2016 Guest Lecturer Chronic Disease Epidemiology EPI602 (1 session)
2017 Guest Lecturer Modeling Human Disease TMS 704/714/724 (1 session)
2017 Guest Lecturer Chronic Disease Epidemiology EPI602 (1 session)
2017 Guest Lecturer Genetic Epidemiology EPI 731 (2 sessions)
2018 Guest Lecturer Graduate Biomedical Sciences GBS 758 (2 sessions)
2018 Guest Lecturer Graduate Biomedical Sciences GBS 748 (1 session)
2018 Guest Lecturer Chronic Disease Epidemiology EPI602 (1 session)
Ryan Irvin CV • January 2017 • 3
Mentoring
Dissertation Committee Member
2013 – 2014 Guodong Wu, PhD, Department of Biostatistics, University of Alabama at
Birmingham.
Dissertation Title: Quantification and Association Analysis for Next-generation
Sequencing Data
2013 – 2014 Rikki Tanner, PhD, MPH, Department of Epidemiology, University of Alabama at
Birmingham.
Dissertation Title: Association of Blood Pressure Phenotypes with Kidney Disease
2013 – 2016 Lindsay Jones, PhD, MS, Department of Biostatistics, University of Alabama at
Birmingham.
Dissertation Title: Statistical Methodology for DNA Methylation Array Analysis
2013 – 2016 Aditi Shendre, PhD, MPH, Department of Epidemiology, University of Alabama at
Birmingham.
Dissertation Title: Admixture mapping of subclinical and clinical cardiovascular
disease among African Americans
2015 – 2016 Yogasudha Veturi, PhD, Department of Biostatistics, University of Alabama at
Birmingham.
Dissertation Title: Methods for analysis of genetic differences in sex and ethnicity
for complex human traits
2015 –2018 Michael P Behring, PhD Candidate, Department of Epidemiology, University of
Alabama at Birmingham.
Dissertation Title: Multi-platform correlates of breast cancer metastasis, aging, and
immune response
2016 –2017 Seth T Lirette, PhD Candidate, Department of Biostatistics, University of Alabama
at Birmingham.
Dissertation Title: Approaching brain perfusion data from a statistical perspective
2016 –2017 Carrie Huisingh, PhD Candidate, Department of Epidemiology, University of
Alabama at Birmingham.
Dissertation Title: Visual, Attentional, and Cognitive Risk Factors for Motor
Vehicle Collision Involvement among Older Adults
2017 –2018 Allison C. Fialkowski, PhD Candidate, Department of Biostatistics, University of
Alabama at Birmingham.
Dissertation Title: Simulation of Correlated Variables, Mixture Distributions, and
Repeated Measures and Comparison of Pharmacogenetic Prediction with Machine
Learning Techniques.
Dissertation Committee Chair
2016 – 2017 Anh Do, PhD Candidate, Department of Epidemiology, University of Alabama at
Birmingham.
Dissertation Title: Effects of antihypertensive drugs on left ventricular traits in
African Americans
2018- Bre Minniefield, PhD Program, Graduate Biomedical Sciences, University of
Alabama at Birmingham.
Dissertation Title: Genomic Background of Blood Pressure Response to Thiazide
Diuretic in African Americans-focus on Mitochondrial DNA and Admixture
mapping (funded by Administrative supplement to 1R01HLHL123782)
Ryan Irvin CV • January 2017 • 4
2018- Ninad Chaudhary, PhD Program, Department of Epidemiology, University of
Alabama at Birmingham.
Dissertation Title: How Inflammation and High Density Lipoproteins Affect the
Relationship Between APOL1 and Outcomes (funded by AHA Award Number
18PRE34000021)
Master Thesis Committee Member
2013 – 2014 Anh Do, MSPH, Department of Epidemiology, University of Alabama at
Birmingham.
Master’s Thesis Title: Pharmacogenetic effects of angiotensinogen gene
polymorphisms on cardiovascular disease outcomes in response to antihypertensive
treatments in the GenHAT study
2015 – 2016 Stephanie Ann Larocco, MSPH, Department of Epidemiology, University of
Alabama at Birmingham.
Master’s Thesis Title: Exomic background of incident cognitive impairment in
elderly African-Americans
2015 – 2016 Anna Junkins, MSPH, Department of Epidemiology, University of Alabama at
Birmingham
Master’s Thesis Title: The association between apparent treatment resistant
hypertension and quality of life, depressive symptoms and stress.
2017 Arnisha Atkins, MSPH, Department of Epidemiology, University of Alabama at
Birmingham
Master’s Thesis Title: Disparities in Breast and Colorectal Cancer Screenings in the
United States by Medicaid Expansion
Master Thesis Committee Chair
2013 – 2014 Ngan Thanh Tran, MSPH, Department of Epidemiology, University of Alabama at
Birmingham.
Master’s Thesis Title: PCSK9 variation and association with blood pressure in
African Americans: Preliminary finding from the HyperGEN and REGARDS
Project published in Frontiers in Genetics 2015
Co-mentor
2013 – 2014 Ngan Thanh Tran, MSPH student, Department of Epidemiology, University of
Alabama at Birmingham.
Research Focus: Pharmacogenomics of Cardiovascular Disease
Accomplishments: UAB Annual Public Health Research Day April 4, 2014 2nd
Place for poster entitled “Interaction of PCSK9 variants with anthropometric traits
on blood pressure in African Americans in the HyperGEN study.”
2014-2015 Mithun Das, Visiting Scholar, Assistant Professor in Anthropology, Sree Chaitanya
College, Habra West Bengal State University, West Bengal, India
Research Focus: Epigenetics
Accomplishments: Two CVD epigenetics papers were published in PLos One and
Frontiers in Genetics
2015 – 2016 Stephanie Ann Larocco, MSPH, Department of Epidemiology, University of
Alabama at Birmingham.
Research Focus: Cognitive genomics. Completed a project in the REGARDS
dataset
Primary Mentor
2017 – Ninad Chaudhary, 3rd year PhD Student, Department of Epidemiology, University of
Ryan Irvin CV • January 2017 • 5
Alabama at Birmingham.
Research Focus: Genomics and Epigenomics of CVD
2017 – Bre Minniefield, 2nd year PhD Student, Graduate Biomedical Sciences, University of
Alabama at Birmingham.
Research Focus: Genomics and Epigenomics of CVD, Copy Number Variants,
Admixture analysis
Accomplishments: Positive Review on Graduate Research Supplement to R01
HL123782 (funding pending December 2017).
MPH Advisor
2013 – 2014 Stephanie Tison, MPH Student, Epidemiology, University of Alabama at
Birmingham
2014 – 2016 Laura Kat Purvis, MPH Student, Epidemiology, University of Alabama at
Birmingham
2014 – 2016 Ana Carr Farout, MPH Student, Epidemiology, University of Alabama at
Birmingham
2015 – 2017 Kevin Wall, MPH Student, Epidemiology, University of Alabama at Birmingham
2016 – Theodule Baptiste, MPH Student, Epidemiology, University of Alabama at
Birmingham
2016 – Emily Ness, MPH Student, Epidemiology, University of Alabama at Birmingham
2016 – Deven Patel, MPH Student, Epidemiology, University of Alabama at Birmingham
2017 – Yi Pan, MPH Student, Epidemiology, University of Alabama at Birmingham
2017 – Valerie Kenny, MPH Student, Epidemiology, University of Alabama at Birmingham
Invited Lectures
2010 “Search for genes associated with metabolic traits in special populations: progress
and pitfalls.” UAB Department of Epidemiology Seminar Series. Birmingham, AL.
2011 “Pharmacogenetics of fenofibrate response in the GOLDN study.” UAB Department
of Epidemiology Seminar Series. February 2011, Birmingham, AL.
2012 “Treatment resistant hypertension: What is it and what puts you at risk?” UAB
Department of Epidemiology Seminar Series. Oct 2012, Birmingham, AL.
2013 “Risk and prognosis in resistant hypertension.” The UAB Vascular Biology and
Hypertension Program Weekly Seminar. February, 2013, Birmingham, AL.
2013 “Genes involved in renal Na+/K+ transport modify risk for diabetes on thiazide
diuretics” UAB Gene discovery approaches workshop. UAB Heflin Center.
November 2013, Birmingham AL
2014 “Disparities and outcomes in resistant hypertension.” CCHA/GRECC Scientific
Seminar Series on Aging. April, 2014, Birmingham, AL.
2014 “Uric Acid Genetics in Minority Populations.” UAB Gout enrichment series.
December, 2014, Birmingham, AL.
2015 “The Emerging Role of Epigenetics in Cardiovascular Disease.” UAB Department
of Epidemiology Seminar Series. February 2015, Birmingham, AL.
2015 “The Emerging Role of Epigenetics in Cardiovascular Disease.” UAB
Comprehensive Cardiovascular Center (CCVC) Seminar Series. February 2015,
Birmingham, AL.
2015 “Epigenetics of Cardiovascular Disease.” UAB Vascular Biology & Hypertension
Seminar Series. November 2015, Birmingham, AL
Ryan Irvin CV • January 2017 • 6
2017 “Cardiovascular Genomics and Pharmacogenomics” UAB Department of
Epidemiology Seminar Series, March 2017
Scientific Journal Activities
Review Editor
Frontiers in Pharmacogenetics and Pharmacogenomics
Frontiers in Applied Genetic Epidemiology
Ad Hoc Reviewer
Obesity
Circulation: Cardiovascular Genetics
Clinical Genetics
Journal of Human Hypertension
PLOS Genetics
PLOS One
American Journal of Clinical Nutrition
Professional Service
School/University
2013 School of Public Health President’s Award for Excellence in Teaching Selection
Committee, University of Alabama at Birmingham
2013 – MSPH Admission Committee, Department of Epidemiology, University of Alabama
at Birmingham
2013 – 2016 Academic Programs Review Committee (APRC), Alternate Member, University of
Alabama at Birmingham
2015 – PhD qualifying exam Committee, Department of Epidemiology, University of
Alabama at Birmingham
2016 –2019 Graduate Curriculum Committee, School of Public Health Representative,
University of Alabama at Birmingham
2017 – Responsible Conduct of Research Advisory Committee (ADCOM), School of
Public Health Representative, University of Alabama at Birmingham
2017 –2019 Faculty Senate, School of Public Health Representative, University of Alabama at
Birmingham
2017 –2019 Faculty Senate Research Committee, School of Public Health Representative,
University of Alabama at Birmingham
2017 – High Performance Computing (HPC) Users Group, University of Alabama at
Birmingham
2017 Kaul Pediatric Research Institute (KPRI) at Children’s of Alabama Pilot application
review
2017 UAB Center for Clinical and Translational Science Pilot application review
2018 UAB Obesity Health Disparities Research Center (OHDRC) Pilot Application
Review
2018 UAB Faculty Development Grant Program Pilot application review
National/International
2013 – 2016 Membership and Communications Committee, Functional Genomics and
Translational Biology Council, American Heart Association
2016 – 2018 Vice Chair Membership and Communications Committee, Functional Genomics and
Translational Biology Council, American Heart Association
Ryan Irvin CV • January 2017 • 7
2018 – 2019 Chair Membership and Communications Committee, Genomics and Precision
Medicine Council, American Heart Association
2014 Study Section, Ad hoc Member, Cardiovascular Genome Phenome Study Review
Panel, American Heart Association
2016 Study Section, Ad hoc Member, Cardiovascular Genome Phenome Study Review
Panel, American Heart Association
2016 – 2017 Study Section, Ad hoc Member, VA Epidemiology Research Program (EPID)
review panel, ad hoc (2 X a year, Summer and Fall)
2017 – 2018 Study Section, Ad hoc Member, Million Veterans Program (MVP)
2018 Study Section, Ad Hoc Member, NIH Center for Scientific Review, The Cancer,
Heart, and Sleep Epidemiology Study Section –Panel B (CHSB) (Spring Review
section 2/22/2018)
Journal Publications
*previously published under Dickson MR and Dickson R
+ co-first author
1. Strange C, Dickson R, Carter C, Carpenter MJ, Holladay B, Lundquist R, Brantly ML. Genetic
testing for alpha1-antitrypsin deficiency. Genet Med. 2004;6:204-210.
2. Stoller JK, Sandhaus RA, Turino G, Dickson R, Rodgers K, Strange C. Delay in diagnosis of
alpha1-antitrypsin deficiency: a continuing problem. Chest. 2005;128:1989-94.
3. Dickson MR, Perry RT, Wiener H, Go RC. Association studies of transforming growth factor-
beta 1 and Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2005;139b:38-41.
4. Strange C, Stoller JK, Sandhaus RA, Dickson R, Turino G. Results of a survey of patients with
alpha-1 antitrypsin deficiency. Respiration. 2006;73:185-190.
5. Carpenter MJ, Strange C, Jones Y, Dickson MR, Carter C, Moseley MA, Gilbert GE. Does
genetic testing result in behavioral health change? Changes in smoking behavior following
testing for alpha-1 antitrypsin deficiency. Ann Behav Med. 2007;33:22-28.
6. Dickson MR, Li J, Wiener HW, Perry RT, Blacker D, Bassett SS, Go RC. A genomic scan for
age at onset of Alzheimer's disease in 437 families from the NIMH Genetic Initiative. Am J Med
Genet B Neuropsychiatr Genet. 2008;147b:784-792. PMC2661765.
7. Dickson MR, Carter CL, Carpenter MJ, McClure RL, McGee DA, Zapka JG, Strange C. Barriers
to genetic testing among persons at risk for alpha-1 antitrypsin deficiency. Genet Test.
2008;12:501-505.
8. Wiener HW, Klei L, Irvin MR, Perry RT, Aliyu MH, Allen TB, Bradford LD, Calkins ME,
Devlin B, Edwards N, Gur RE, Gur RC, Kwentus J, Lyons PD, McEvoy JP, Nasrallah HA,
Nimgaonkar VL, O'Jile J, Santos AB, Savage RM, Go RC. Linkage analysis of schizophrenia in
African-American families. Schizophr Res. 2009;109:70-79. PMC2721327.
9. Irvin MR, Wiener HW, Perry RP, Savage RM, Go RC. Genetic risk factors for type 2 diabetes
with pharmacologic intervention in African-American patients with schizophrenia or
schizoaffective disorder. Schizophr Res. 2009;114:50-56. PMC2753171.
10. Shrestha S, Irvin MR, Taylor KD, Wiener HW, Pajewski NM, Haritunians T, Delaney JA,
Schambelan M, Polak JF, Arnett DK, Chen YD, Grunfeld C. A genome-wide association study
of carotid atherosclerosis in HIV-infected men. Aids. 2010;24:583-592. PMC3072760.
11. Irvin MR, Lynch AI, Kabagambe EK, Tiwari HK, Barzilay JI, Eckfeldt JH, Boerwinkle E, Davis
BR, Ford CE, Arnett DK. Pharmacogenetic association of hypertension candidate genes with
fasting glucose in the GenHAT Study. J Hypertens. 2010;28:2076-2083. PMC2957368.
Ryan Irvin CV • January 2017 • 8
12. Irvin MR, Kabagambe EK, Tiwari HK, Parnell LD, Straka RJ, Tsai M, Ordovas JM, Arnett DK.
Apolipoprotein E polymorphisms and postprandial triglyceridemia before and after fenofibrate
treatment in the Genetics of Lipid Lowering and Diet Network (GOLDN) Study. Circ
Cardiovasc Genet. 2010;3:462-467. PMC3119521.
13. Zhang Q, Irvin MR, Arnett DK, Province MA, Borecki I. A data-driven method for identifying
rare variants with heterogeneous trait effects. Genet Epidemiol. 2011;35:679-685. PMC3201701.
14. Irvin MR, Shrestha S, Chen YD, Wiener HW, Haritunians T, Vaughan LK, Tiwari HK, Taylor
KD, Scherzer R, Saag MS, Grunfeld C, Rotter JI, Arnett DK. Genes linked to energy metabolism
and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution
in HIV-infected men. Pharmacogenet Genomics. 2011;21:798-807. PMC3210910.
15. Irvin MR, Wineinger NE, Rice TK, Pajewski NM, Kabagambe EK, Gu CC, Pankow J, North
KE, Wilk JB, Freedman BI, Franceschini N, Broeckel U, Tiwari HK, Arnett DK. Genome-wide
detection of allele specific copy number variation associated with insulin resistance in African
Americans from the HyperGEN study. PLoS One. 2011;6:e24052. PMC3162025.
16. Aslibekyan S, Kabagambe EK, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY, Hopkins
PN, Shen J, Lai CQ, Ordovas JM, Arnett DK. A genome-wide association study of inflammatory
biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug
and Diet Network. Pharmacogenet Genomics. 2012;22:191-197. PMC3275691.
17. Irvin MR, Zhang Q, Kabagambe EK, Perry RT, Straka RJ, Tiwari HK, Borecki IB, Shimmin
LC, Stuart C, Zhong Y, Hixson JE, Arnett DK. Rare PPARA variants and extreme response to
fenofibrate in the Genetics of Lipid-Lowering Drugs and Diet Network Study. Pharmacogenet
Genomics. 2012;22:367-372. PMC3325369.
18. Zhi D+, Irvin MR+, Gu CC, Stoddard AJ, Lorier R, Matter A, Rao DC, Srinivasasainagendra V,
Tiwari HK, Turner A, Broeckel U, Arnett DK. Whole-exome sequencing and an iPSC-derived
cardiomyocyte model provides a powerful platform for gene discovery in left ventricular
hypertrophy. Front Genet. 2012;3:92. PMC3361011.
19. Lynch AI, Irvin MR, Boerwinkle E, Davis BR, Vaughan LK, Ford CE, Aissani B, Eckfeldt JH,
Arnett DK, Shrestha S. RYR3 gene polymorphisms and cardiovascular disease outcomes in the
context of antihypertensive treatment. Pharmacogenomics J. 2013;13:330-334. PMC3435442.
20. Irvin MR, Shimbo D, Mann DM, Reynolds K, Krousel-Wood M, Limdi NA, Lackland DT,
Calhoun DA, Oparil S, Muntner P. Prevalence and correlates of low medication adherence in
apparent treatment-resistant hypertension. J Clin Hypertens (Greenwich). 2012;14:694-700.
PMC3464920.
21. Aslibekyan S, Goodarzi MO, Frazier-Wood AC, Yan X, Irvin MR, Kim E, Tiwari HK, Guo X,
Straka RJ, Taylor KD, Tsai MY, Hopkins PN, Korenman SG, Borecki IB, Chen YD, Ordovas
JM, Rotter JI, Arnett DK. Variants identified in a GWAS meta-analysis for blood lipids are
associated with the lipid response to fenofibrate. PLoS One. 2012;7:e48663. PMC3485381.
22. Aslibekyan S, An P, Frazier-Wood AC, Kabagambe EK, Irvin MR, Straka RJ, Tiwari HK, Tsai
MY, Hopkins PN, Borecki IB, Ordovas JM, Arnett DK. Preliminary evidence of genetic
determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and
Diet Network. Nutr Metab Cardiovasc Dis. 2013;23:987-994. PMC3578131.
23. Peters U, North KE, Sethupathy P, Buyske S, Haessler J, Jiao S, Fesinmeyer MD, Jackson RD,
Kuller LH, Rajkovic A, Lim U, Cheng I, Schumacher F, Wilkens L, Li R, Monda K, Ehret G,
Nguyen KD, Cooper R, Lewis CE, Leppert M, Irvin MR, Gu CC, Houston D, Buzkova P,
Ritchie M, Matise TC, Le Marchand L, Hindorff LA, Crawford DC, Haiman CA, Kooperberg C.
A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African
Americans narrows in on the underlying functional variation: results from the Population
Ryan Irvin CV • January 2017 • 9
Architecture using Genomics and Epidemiology (PAGE) study. PLoS Genet. 2013;9:e1003171.
PMC3547789.
24. Aslibekyan S, Straka RJ, Irvin MR, Claas SA, Arnett DK. Pharmacogenomics of high-density
lipoprotein-cholesterol-raising therapies. Expert Rev Cardiovasc Ther. 2013;11:355-364.
25. Monda KL, Chen GK, Taylor KC, Palmer C, Edwards TL, Lange LA, Ng MC, Adeyemo AA,
Allison MA, Bielak LF, Chen G, Graff M, Irvin MR, Rhie SK, Li G, Liu Y, Liu Y, Lu Y, Nalls
MA, Sun YV, Wojczynski MK, Yanek LR, Aldrich MC, Ademola A, Amos CI, Bandera EV,
Bock CH, Britton A, Broeckel U, Cai Q, Caporaso NE, Carlson CS, Carpten J, Casey G, Chen
WM, Chen F, Chen YD, Chiang CW, Coetzee GA, Demerath E, Deming-Halverson SL, Driver
RW, Dubbert P, Feitosa MF, Feng Y, Freedman BI, Gillanders EM, Gottesman O, Guo X,
Haritunians T, Harris T, Harris CC, Hennis AJ, Hernandez DG, McNeill LH, Howard TD,
Howard BV, Howard VJ, Johnson KC, Kang SJ, Keating BJ, Kolb S, Kuller LH, Kutlar A,
Langefeld CD, Lettre G, Lohman K, Lotay V, Lyon H, Manson JE, Maixner W, Meng YA,
Monroe KR, Morhason-Bello I, Murphy AB, Mychaleckyj JC, Nadukuru R, Nathanson KL,
Nayak U, N'Diaye A, Nemesure B, Wu SY, Leske MC, Neslund-Dudas C, Neuhouser M, Nyante
S, Ochs-Balcom H, Ogunniyi A, Ogundiran TO, Ojengbede O, Olopade OI, Palmer JR, Ruiz-
Narvaez EA, Palmer ND, Press MF, Rampersaud E, Rasmussen-Torvik LJ, Rodriguez-Gil JL,
Salako B, Schadt EE, Schwartz AG, Shriner DA, Siscovick D, Smith SB, Wassertheil-Smoller S,
Speliotes EK, Spitz MR, Sucheston L, Taylor H, Tayo BO, Tucker MA, Van Den Berg DJ,
Edwards DR, Wang Z, Wiencke JK, Winkler TW, Witte JS, Wrensch M, Wu X, Yang JJ, Levin
AM, Young TR, Zakai NA, Cushman M, Zanetti KA, Zhao JH, Zhao W, Zheng Y, Zhou J,
Ziegler RG, Zmuda JM, Fernandes JK, Gilkeson GS, Kamen DL, Hunt KJ, Spruill IJ,
Ambrosone CB, Ambs S, Arnett DK, Atwood L, Becker DM, Berndt SI, Bernstein L, Blot WJ,
Borecki IB, Bottinger EP, Bowden DW, Burke G, Chanock SJ, Cooper RS, Ding J, Duggan D,
Evans MK, Fox C, Garvey WT, Bradfield JP, Hakonarson H, Grant SF, Hsing A, Chu L, Hu JJ,
Huo D, Ingles SA, John EM, Jordan JM, Kabagambe EK, Kardia SL, Kittles RA, Goodman PJ,
Klein EA, Kolonel LN, Le Marchand L, Liu S, McKnight B, Millikan RC, Mosley TH,
Padhukasahasram B, Williams LK, Patel SR, Peters U, Pettaway CA, Peyser PA, Psaty BM,
Redline S, Rotimi CN, Rybicki BA, Sale MM, Schreiner PJ, Signorello LB, Singleton AB,
Stanford JL, Strom SS, Thun MJ, Vitolins M, Zheng W, Moore JH, Williams SM, Ketkar S, Zhu
X, Zonderman AB, Kooperberg C, Papanicolaou GJ, Henderson BE, Reiner AP, Hirschhorn JN,
Loos RJ, North KE, Haiman CA. A meta-analysis identifies new loci associated with body mass
index in individuals of African ancestry. Nat Genet. 2013;45:690-696. PMC3694490.
26. Zhi D, Aslibekyan S, Irvin MR, Claas SA, Borecki IB, Ordovas JM, Absher DM, Arnett DK.
SNPs located at CpG sites modulate genome-epigenome interaction. Epigenetics. 2013;8:802-
806. PMC3883783.
27. Tanner RM, Calhoun DA, Bell EK, Bowling CB, Gutierrez OM, Irvin MR, Lackland DT, Oparil
S, Warnock D, Muntner P. Prevalence of apparent treatment-resistant hypertension among
individuals with CKD. Clin J Am Soc Nephrol. 2013;8:1583-1590. PMC3805064.
28. Liu CT, Monda KL, Taylor KC, Lange L, Demerath EW, Palmas W, Wojczynski MK, Ellis JC,
Vitolins MZ, Liu S, Papanicolaou GJ, Irvin MR, Xue L, Griffin PJ, Nalls MA, Adeyemo A, Liu
J, Li G, Ruiz-Narvaez EA, Chen WM, Chen F, Henderson BE, Millikan RC, Ambrosone CB,
Strom SS, Guo X, Andrews JS, Sun YV, Mosley TH, Yanek LR, Shriner D, Haritunians T,
Rotter JI, Speliotes EK, Smith M, Rosenberg L, Mychaleckyj J, Nayak U, Spruill I, Garvey WT,
Pettaway C, Nyante S, Bandera EV, Britton AF, Zonderman AB, Rasmussen-Torvik LJ, Chen
YD, Ding J, Lohman K, Kritchevsky SB, Zhao W, Peyser PA, Kardia SL, Kabagambe E,
Broeckel U, Chen G, Zhou J, Wassertheil-Smoller S, Neuhouser ML, Rampersaud E, Psaty B,
Kooperberg C, Manson JE, Kuller LH, Ochs-Balcom HM, Johnson KC, Sucheston L, Ordovas
Ryan Irvin CV • January 2017 • 10
JM, Palmer JR, Haiman CA, McKnight B, Howard BV, Becker DM, Bielak LF, Liu Y, Allison
MA, Grant SF, Burke GL, Patel SR, Schreiner PJ, Borecki IB, Evans MK, Taylor H, Sale MM,
Howard V, Carlson CS, Rotimi CN, Cushman M, Harris TB, Reiner AP, Cupples LA, North KE,
Fox CS. Genome-wide association of body fat distribution in African ancestry populations
suggests new loci. PLoS Genet. 2013;9:e1003681. PMC3744443.
29. Gong J, Schumacher F, Lim U, Hindorff LA, Haessler J, Buyske S, Carlson CS, Rosse S,
Buzkova P, Fornage M, Gross M, Pankratz N, Pankow JS, Schreiner PJ, Cooper R, Ehret G, Gu
CC, Houston D, Irvin MR, Jackson R, Kuller L, Henderson B, Cheng I, Wilkens L, Leppert M,
Lewis CE, Li R, Nguyen KD, Goodloe R, Farber-Eger E, Boston J, Dilks HH, Ritchie MD,
Fowke J, Pooler L, Graff M, Fernandez-Rhodes L, Cochrane B, Boerwinkle E, Kooperberg C,
Matise TC, Le Marchand L, Crawford DC, Haiman CA, North KE, Peters U. Fine Mapping and
Identification of BMI Loci in African Americans. Am J Hum Genet. 2013;93:661-671.
PMC3791273.
30. Lynch AI, Irvin MR, Davis BR, Ford CE, Eckfeldt JH, Arnett DK. Genetic and Adverse Health
Outcome Associations with Treatment Resistant Hypertension in GenHAT. Int J Hypertens.
2013;2013:578578. PMC3833110.
31. Katz DH, Selvaraj S, Aguilar FG, Martinez EE, Beussink L, Kim KY, Peng J, Sha J, Irvin MR,
Eckfeldt JH, Turner ST, Freedman BI, Arnett DK, Shah SJ. Association of low-grade
albuminuria with adverse cardiac mechanics: findings from the hypertension genetic
epidemiology network (HyperGEN) study. Circulation. 2014;129:42-50. PMC3888488.
32. Hidalgo B, Irvin MR, Sha J, Zhi D, Aslibekyan S, Absher D, Tiwari HK, Kabagambe EK,
Ordovas JM, Arnett DK. Epigenome-wide association study of fasting measures of glucose,
insulin, and HOMA-IR in the Genetics of Lipid Lowering Drugs and Diet Network study.
Diabetes. 2014;63:801-807. PMC3968438.
33. Shrestha S, Irvin MR, Grunfeld C, Arnett DK. HIV, inflammation, and calcium in
atherosclerosis. Arterioscler Thromb Vasc Biol. 2014;34:244-250. PMID24265418
34. Calhoun DA, Booth JN, 3rd, Oparil S, Irvin MR, Shimbo D, Lackland DT, Howard G, Safford
MM, Muntner P. Refractory hypertension: determination of prevalence, risk factors, and
comorbidities in a large, population-based cohort. Hypertension. 2014;63:451-458.
PMC4141646.
35. Tanner RM, Calhoun DA, Bell EK, Bowling CB, Gutierrez OM, Irvin MR, Lackland DT, Oparil
S, McClellan W, Warnock DG, Muntner P. Incident ESRD and treatment-resistant hypertension:
the reasons for geographic and racial differences in stroke (REGARDS) study. Am J Kidney Dis.
2014;63:781-788. PMC4141647.
36. Shendre A, Irvin MR, Aouizerat BE, Wiener HW, Vazquez AI, Anastos K, Lazar J, Liu C,
Karim R, Limdi NA, Cohen MH, Golub ET, Zhi D, Kaplan RC, Shrestha S. RYR3 gene variants
in subclinical atherosclerosis among HIV-infected women in the Women's Interagency HIV
Study (WIHS). Atherosclerosis. 2014;233:666-672. PMC3965606.
37. Selvaraj S, Aguilar FG, Martinez EE, Beussink L, Kim KY, Peng J, Rasmussen-Torvik L, Sha J,
Irvin MR, Gu CC, Lewis CE, Hunt SC, Arnett DK, Shah SJ. Association of comorbidity burden
with abnormal cardiac mechanics: findings from the HyperGEN study. J Am Heart Assoc.
2014;3:e000631. PMC4309045
38. Irvin MR, Aslibekyan S, Hidalgo B, Arnett DK. CPT1A: the future of heart disease detection
and personalized medicine? Future Medicine Clin Lipidol. 2014;9:9-12. PMC4358228
39. Irvin MR, Zhi D, Aslibekyan S, Claas SA, Absher DM, Ordovas JM, Tiwari HK, Watkins S,
Arnett DK. Genomics of post-prandial lipidomic phenotypes in the Genetics of Lipid lowering
Drugs and Diet Network (GOLDN) study. PLoS One. 2014;9:e99509. PMC4048279.
Ryan Irvin CV • January 2017 • 11
40. Diaz KM, Booth JN, 3rd, Calhoun DA, Irvin MR, Howard G, Safford MM, Muntner P, Shimbo
D. Healthy lifestyle factors and risk of cardiovascular events and mortality in treatment-resistant
hypertension: the Reasons for Geographic and Racial Differences in Stroke study. Hypertension.
2014;64:465-471. PMC4134352.
41. Irvin MR, Zhi D, Joehanes R, Mendelson M, Aslibekyan S, Claas SA, Thibeault KS, Patel N,
Day K, Jones LW, Liang L, Chen BH, Yao C, Tiwari HK, Ordovas JM, Levy D, Absher D,
Arnett DK. Epigenome-wide association study of fasting blood lipids in the Genetics of Lipid-
lowering Drugs and Diet Network study. Circulation. 2014;130:565-572. PMC4209699.
42. Irvin MR, Booth JN, 3rd, Shimbo D, Lackland DT, Oparil S, Howard G, Safford MM, Muntner
P, Calhoun DA. Apparent treatment-resistant hypertension and risk for stroke, coronary heart
disease, and all-cause mortality. J Am Soc Hypertens. 2014;8:405-413. PMC4120268.
43. Sorensen IF, Vazquez AI, Irvin MR, Sorensen P, Davis BR, Ford CE, Boerwinkle E, Eckfeldt
JH, Arnett DK. Pharmacogenetic effects of 'candidate gene complexes' on stroke in the GenHAT
study. Pharmacogenet Genomics. 2014;24:556-563. PMC4189974.
44. Selvaraj S, Aguilar FG, Martinez EE, Beussink L, Kim KY, Peng J, Lee DC, Patel A, Sha J,
Irvin MR, Arnett DK, Shah SJ. Diastolic wall strain: a simple marker of abnormal cardiac
mechanics. Cardiovasc Ultrasound. 2014;12:40. PMC4197332.
45. Liu CT, Buchkovich ML, Winkler TW, Heid IM; African Ancestry Anthropometry Genetics
Consortium; GIANT Consortium, Borecki IB, Fox CS, Mohlke KL, North KE, Adrienne
Cupples L. Multi-ethnic fine-mapping of 14 central adiposity loci. Hum Mol Genet.
2014;23:4738-44. PMC4119415
46. Do AN, Irvin MR, Lynch AI, Claas SA, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Tiwari
HK, Limdi NA, Arnett DK. The effects of angiotensinogen gene polymorphisms on
cardiovascular disease outcomes during antihypertensive treatment in the GenHAT study. Front
Pharmacol. 2014;5:210. PMC4165277.
47. Zhi D, Shendre A, Scherzer R, Irvin MR, Perry RT, Levy S, Arnett DK, Grunfeld C, Shrestha S.
Deep sequencing of RYR3 gene identifies rare and common variants associated with increased
carotid intima-media thickness (cIMT) in HIV-infected individuals. J Hum Genet. 2015;60:63-7.
48. Aslibekyan S, Demerath EW, Mendelson M, Zhi D, Guan W, Liang L, Sha J, Pankow JS, Liu C,
Irvin MR, Fornage M, Hidalgo B, Lin LA, Thibeault KS, Bressler J, Tsai MY, Grove ML,
Hopkins PN, Boerwinkle E, Borecki IB, Ordovas JM, Levy D, Tiwari HK, Absher DM, Arnett
DK. Epigenome-wide study identifies novel methylation loci associated with body mass index
and waist circumference. Obesity. 2015;23:1493-501. PMC4482015
49. Demerath EW, Guan W, Grove ML, Aslibekyan S, Mendelson M, Zhou YH, Hedman ÅK,
Sandling JK, Li LA, Irvin MR, Zhi D, Deloukas P, Liang L, Liu C, Bressler J, Spector TD,
North K, Li Y, Absher DM, Levy D, Arnett DK, Fornage M, Pankow JS, Boerwinkle E.
Epigenome-wide association study (EWAS) of BMI, BMI change and waist circumference in
African American adults identifies multiple replicated loci. Hum Mol Genet. 2015;24:4464-79.
PMC4492394.
50. Ma Y, Smith CE, Lai CQ, Irvin MR, Parnell LD, Lee YC, Pham L, Aslibekyan S, Claas SA,
Tsai MY, Borecki IB, Kabagambe EK, Berciano S, Ordovas JM, Absher DM, Arnett DK.
Genetic variants modify the effect of age on APOE methylation in the Genetics of Lipid
Lowering Drugs and Diet Network study. Aging Cell. 2015;14:49-59. PMC4324456
51. Howard VJ, Tanner RM, Anderson A, Irvin MR, Calhoun DA, Lackland DT, Oparil S, Muntner
P. Apparent treatment-resistant hypertension among individuals with history of stroke or
transient ischemic attack. Am J Med. 2015;128:707-14. PMC4475646
Ryan Irvin CV • January 2017 • 12
52. Mozaffarian D, Kabagambe EK, Johnson CO, Lemaitre RN, Manichaikul A, Sun Q, Foy M,
Wang L, Wiener H, Irvin MR, Rich SS, Wu H, Jensen MK, Chasman DI, Chu AY, Fornage M,
Steffen L, King IB, McKnight B, Psaty BM, Djoussé L, Chen IY, Wu JH, Siscovick DS, Ridker
PM, Tsai MY, Rimm EB, Hu FB, Arnett DK. Genetic loci associated with circulating
phospholipid trans fatty acids: a meta-analysis of genome-wide association studies from the
CHARGE Consortium. Am J Clin Nutr. 2015;101:398-406. PMC4307209
53. Tran NT, Aslibekyan S, Tiwari HK, Zhi D, Sung YJ, Hunt SC, Rao DC, Broeckel U, Judd S,
Muntner P, Kent ST, Arnett DK, Irvin MR. PCSK9 variation and association with blood
pressure in African Americans: preliminary findings from the HyperGEN and REGARDS
studies. Frontiers in Genetics. 2015;6:136. PMC4389541
54. Gutiérrez OM, Judd SE, Irvin MR, Zhi D, Limdi N, Palmer ND, Rich SS, Sale MM, Freedman
BI. APOL1 nephropathy risk variants are associated with altered high-density lipoprotein profiles
in African Americans. Nephrol Dial Transplant. 2016;31:602-8. PMC4805128
55. Das M, Irvin MR, Sha J, Aslibekyan S, Hidalgo B, Perry RT, Zhi D, Tiwari HK, Absher D,
Ordovas JM, Arnett DK. Lipid changes due to fenofibrate treatment are not associated with
changes in DNA methylation patterns in the GOLDN study. Front Genet. 2015;6:304.
PMC4586504
56. Aguilar FG, Selvaraj S, Martinez EE, Katz DH, Beussink L, Kim KY, Ping J, Rasmussen-Torvik
L, Goyal A, Sha J, Irvin MR, Arnett DK, Shah SJ. Archeological Echocardiography:
Digitization and Speckle Tracking Analysis of Archival Echocardiograms in the HyperGEN
Study. Echocardiography. 2016;33:386-97. PMC4775325
57. Hidalgo B, Aslibekyan S, Wiener HW, Irvin MR, Straka RJ, Borecki IB, Tiwari HK, Tsai MY,
Hopkins PN, Ordovas JM, Arnett DK. A family-specific linkage analysis of blood lipid response
to fenofibrate in the Genetics of Lipid Lowering Drug and Diet Network. Pharmacogenet
Genomics. 2015;25:511-4. PMC4558213
58. Bis JC, Sitlani C, Irvin MR, Avery CL, Smith AV, Sun F, Evans DS, Musani SK, Li X8,
Trompet S, Krijthe BP, Harris TB, Quibrera PM, Brody JA, Demissie S, Davis BR, Wiggins KL,
Tranah GJ, Lange LA, Sotoodehnia N, Stott DJ, Franco OH, Launer LJ, Stürmer T, Taylor KD,
Cupples LA, Eckfeldt JH, Smith NL, Liu Y, Wilson JG, Heckbert SR, Buckley BM, Ikram MA,
Boerwinkle E, Chen YD, de Craen AJ, Uitterlinden AG, Rotter JI, Ford I, Hofman A, Sattar N,
Slagboom PE, Westendorp RG, Gudnason V, Vasan RS, Lumley T, Cummings SR, Taylor HA
Jr, Post W, Jukema JW, Stricker BH, Whitsel EA, Psaty BM, Arnett D. Drug-gene interactions of
antihypertensive medications and risk of incident cardiovascular disease: a pharmacogenomics
study from the CHARGE consortium. PLoS One. 2015;10:e0140496. PMC4627813
59. Ma Y, Smith CE, Lai CQ, Irvin MR, Parnell LD, Lee YC, Pham L, Aslibekyan S, Claas SA,
Tsai MY, Borecki IB, Kabagambe EK, Ordovás JM, Absher DM, Arnett DK. The effects of
omega-3 polyunsaturated fatty acids and genetic variants on methylation levels of the interleukin-
6 gene promoter. Mol Nutr Food Res. 2016;60:410-9. PMC4844557
60. Das M, Sha J, Hidalgo B, Aslibekyan S, Do AN, Zhi D, Sun D, Zhang T, Li S, Chen W,
Srinivasan SR, Tiwari HK, Absher D, Ordovas JM, Berenson GS, Arnett DK, Irvin MR.
Association of DNA Methylation at CPT1A Locus with Metabolic Syndrome in the Genetics of
Lipid Lowering Drugs and Diet Network (GOLDN) Study. PLoS One. 2016;11:e0145789.
PMC4726462
61. NINDS Stroke Genetics Network (SiGN) and International Stroke Genetics Consortium (ISGC).
Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.
Lancet Neurol. 2016;15:174-184. PMC4912948.
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62. Huisingh C, Levitan EB, Irvin MR, Owsley C, McGwin G Jr. Driving with pets and motor
vehicle collision involvement among older drivers: A prospective population-based study. Accid
Anal Prev. 2016;88:169-74. PMC4738176
63. Do AN, Lynch AI, Claas SA, Boerwinkle E, Davis BR, Ford CE, Eckfeldt JH, Tiwari HK, Arnett
DK, Irvin MR. The effects of genes implicated in cardiovascular disease on blood pressure
response to treatment among treatment-naive hypertensive African Americans in the GenHAT
study. J Hum Hypertens. 2016;30:549-54. PMC4956602
64. Palmer ND, Divers J, Lu L, Register TC, Carr JJ, Hicks PJ, Smith SC, Xu J, Judd SE, Irvin MR,
Gutierrez OM, Bowden DW, Wagenknecht LE, Langefeld CD, Freedman BI. Admixture
mapping of serum vitamin D and parathyroid hormone concentrations in the African American-
Diabetes Heart Study. Bone. 2016;87:71-7. PMC4862915
65. Irvin MR, Rotroff DM, Aslibekyan S, Zhi D, Hidalgo B, Motsinger-Reif A, Marvel S,
Srinivasasainagendra V, Claas SA, Buse JB, Straka RJ, Ordovas JM, Borecki IB, Guo X, Chen
IY, Rotter JI, Wagner MJ, Arnett DK. A genome-wide study of lipid response to fenofibrate in
Caucasians: a combined analysis of the GOLDN and ACCORD studies. Pharmacogenet
Genomics. 2016;26:324-33. PMC4986826
66. Selvaraj S, Martinez EE, Aguilar FG, Kim KY, Peng J, Sha J, Irvin MR, Lewis CE, Hunt SC,
Arnett DK, Shah SJ. Association of Central Adiposity with Adverse Cardiac Mechanics:Findings
from the HyperGEN Study. Circ Cardiovasc Imaging. 2016;9;e004396. PMC4911824
67. Liu CT, Raghavan S, Maruthur N, Kabagambe EK, Hong J, Ng MC, Hivert MF, Lu Y, An P,
Bentley AR, Drolet AM, Gaulton KJ, Guo X, Armstrong LL, Irvin MR, Li M, Lipovich L, Rybin
DV, Taylor KD, Agyemang C, Palmer ND, Cade BE, Chen WM, Dauriz M, Delaney JA,
Edwards TL, Evans DS, Evans MK, Lange LA, Leong A, Liu J, Liu Y, Nayak U, Patel SR,
Porneala BC, Rasmussen-Torvik LJ, Snijder MB, Stallings SC, Tanaka T, Yanek LR, Zhao W,
Becker DM, Bielak LF, Biggs ML, Bottinger EP, Bowden DW, Chen G, Correa A, Couper DJ,
Crawford DC, Cushman M, Eicher JD, Fornage M, Franceschini N, Fu YP, Goodarzi MO,
Gottesman O, Hara K, Harris TB, Jensen RA, Johnson AD, Jhun MA, Karter AJ, Keller MF, Kho
AN, Kizer JR, Krauss RM, Langefeld CD, Li X, Liang J, Liu S, Lowe WL Jr, Mosley TH, North
KE, Pacheco JA, Peyser PA, Patrick AL, Rice KM, Selvin E, Sims M, Smith JA, Tajuddin SM,
Vaidya D, Wren MP, Yao J, Zhu X, Ziegler JT, Zmuda JM, Zonderman AB, Zwinderman AH;
AAAG Consortium.; CARe Consortium.; COGENT-BP Consortium.; eMERGE Consortium.;
MEDIA Consortium., Adeyemo A, Boerwinkle E, Ferrucci L, Hayes MG, Kardia SL, Miljkovic
I, Pankow JS, Rotimi CN, Sale MM, Wagenknecht LE, Arnett DK, Chen YD, Nalls MA;
MAGIC Consortium., Province MA, Kao WH, Siscovick DS, Psaty BM, Wilson JG, Loos RJ,
Dupuis J, Rich SS, Florez JC, Rotter JI, Morris AP, Meigs JB. Trans-ethnic Meta-analysis and
Functional Annotation Illuminates the Genetic Architecture of Fasting Glucose and Insulin. Am J
Hum Genet. 2016;99:56-75. PMC5005440
68. Moore JX, Zakai NA, Mahalingam M, Griffin RL, Irvin MR, Safford MM, Baddley JW, Wang
HE. Hemostasis Biomarkers and Risk of Sepsis: the REasons for Geographic And Racial
Differences in Stroke (REGARDS) cohort. J Thromb Haemost. 2016;14:2169-76. PMC in
process
69. Chami N, Chen MH, Slater AJ, Eicher JD, Evangelou E, Tajuddin SM, Love-Gregory L,
Kacprowski T, Schick UM, Nomura A, Giri A, Lessard S, Brody JA, Schurmann C, Pankratz N,
Yanek LR, Manichaikul A, Pazoki R, Mihailov E, Hill WD, Raffield LM, Burt A, Bartz TM,
Becker DM, Becker LC, Boerwinkle E, Bork-Jensen J, Bottinger EP, O'Donoghue ML, Crosslin
DR, de Denus S, Dubé MP, Elliott P, Engström G, Evans MK, Floyd JS, Fornage M, Gao H,
Greinacher A, Gudnason V, Hansen T, Harris TB, Hayward C, Hernesniemi J, Highland HM,
Ryan Irvin CV • January 2017 • 14
Hirschhorn JN, Hofman A, Irvin MR, Kähönen M, Lange E, Launer LJ, Lehtimäki T, Li J,
Liewald DC, Linneberg A, Liu Y, Lu Y, Lyytikäinen LP, Mägi R, Mathias RA, Melander O,
Metspalu A, Mononen N, Nalls MA, Nickerson DA, Nikus K, O'Donnell CJ, Orho-Melander M,
Pedersen O, Petersmann A, Polfus L, Psaty BM, Raitakari OT, Raitoharju E, Richard M, Rice
KM, Rivadeneira F, Rotter JI, Schmidt F, Smith AV, Starr JM, Taylor KD, Teumer A, Thuesen
BH, Torstenson ES, Tracy RP, Tzoulaki I, Zakai NA, Vacchi-Suzzi C, van Duijn CM, van Rooij
FJ, Cushman M, Deary IJ, Velez Edwards DR, Vergnaud AC, Wallentin L, Waterworth DM,
White HD, Wilson JG, Zonderman AB, Kathiresan S, Grarup N, Esko T, Loos RJ, Lange LA,
Faraday N, Abumrad NA, Edwards TL, Ganesh SK, Auer PL, Johnson AD, Reiner AP, Lettre G.
Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. Am J
Hum Genet. 2016;99:8-21. PMC5005438
70. Liu C, Marioni RE, Hedman ÅK, Pfeiffer L, Tsai PC, Reynolds LM, Just AC, Duan Q, Boer CG,
Tanaka T, Elks CE, Aslibekyan S, Brody JA, Kühnel B, Herder C, Almli LM, Zhi D, Wang Y,
Huan T, Yao C, Mendelson MM, Joehanes R, Liang L, Love SA,Guan W, Shah S, McRae AF,
Kretschmer A, Prokisch H, Strauch K, Peters A, Visscher PM, Wray NR, Guo X, Wiggins KL,
Smith AK, Binder EB, Ressler KJ, Irvin MR, Absher DM, Hernandez D, Ferrucci L, Bandinelli
S, Lohman K, Ding J, Trevisi L, Gustafsson S, Sandling JH, Stolk L, Uitterlinden AG, Yet I,
Castillo-Fernandez JE, Spector TD, Schwartz JD, Vokonas P, Lind L, Li Y, Fornage M, Arnett
DK, Wareham NJ, Sotoodehnia N, Ong KK, van Meurs JB, Conneely KN, Baccarelli AA, Deary
IJ, Bell JT, North KE, Liu Y, Waldenberger M, London SJ, Ingelsson E, Levy D. A DNA
methylation biomarker of alcohol consumption. Mol Psychiatry. 2016 Nov 15. doi:
10.1038/mp.2016.192. PMC5575985
71. Day K, Waite LL, Alonso A, Irvin MR, Zhi D, Thibeault KS, Aslibekyan S, Hidalgo B, Borecki
IB, Ordovas JM, Arnett DK, Tiwari HK, Absher DM. Heritable DNA Methylation in CD4+ Cells
among Complex Families Displays Genetic and Non-Genetic Effects. PLoS One.
2016;11:e0165488. PMC5085095
72. Joehanes R, Just AC, Marioni RE, Pilling LC, Reynolds LM, Mandaviya PR, Guan W, Xu T,
Elks CE, Aslibekyan S, Moreno-Macias H, Smith JA, Brody JA, Dhingra R, Yousefi P, Pankow
JS, Kunze S, Shah SH, McRae AF, Lohman K, Sha J, Absher DM, Ferrucci L, Zhao W,
Demerath EW, Bressler J, Grove ML, Huan T, Liu C, Mendelson MM, Yao C, Kiel DP, Peters
A, Wang-Sattler R, Visscher PM, Wray NR, Starr JM, Ding J, Rodriguez CJ, Wareham NJ, Irvin
MR, Zhi D, Barrdahl M, Vineis P, Ambatipudi S, Uitterlinden AG, Hofman A, Schwartz J,
Colicino E, Hou L, Vokonas PS, Hernandez DG, Singleton AB, Bandinelli S, Turner ST, Ware
EB, Smith AK, Klengel T, Binder EB, Psaty BM, Taylor KD, Gharib SA, Swenson BR, Liang L,
DeMeo DL, O'Connor GT, Herceg Z, Ressler KJ, Conneely KN, Sotoodehnia N, Kardia SL,
Melzer D, Baccarelli AA, van Meurs JB, Romieu I, Arnett DK, Ong KK, Liu Y, Waldenberger
M, Deary IJ, Fornage M, Levy D, London SJ. Epigenetic Signatures of Cigarette Smoking. Circ
Cardiovasc Genet. 2016;9:436-447. PMC5267325.
73. Yoneyama S, Yao J, Guo X, Fernandez-Rhodes L, Lim U, Boston J, Buzková P, Carlson CS,
Cheng I, Cochran B, Cooper R, Ehret G, Fornage M, Gong J, Gross M, Gu CC, Haessler J,
Haiman CA, Henderson B, Hindorff LA, Houston D, Irvin MR, Jackson R, Kuller L, Leppert M,
Lewis CE, Li R, Le Marchand L, Matise TC, Nguyen KD, Chakravarti A, Pankow JS, Pankratz
N, Pooler L, Ritchie MD, Bien SA, Wassel CL, Chen YD, Taylor KD, Allison M, Rotter JI,
Schreiner PJ, Schumacher F, Wilkens L, Boerwinkle E, Kooperberg C, Peters U, Buyske S, Graff
M, North KE. Generalization and fine mapping of European ancestry-based central adiposity
variants in African ancestry populations. Int J Obes (Lond). 2017;41:324-331 PMC5296276.
74. Lai CQ, Wojczynski MK, Parnell LD, Hidalgo BA, Irvin MR, Aslibekyan S, Province MA,
Absher DM, Arnett DK, Ordovás JM. Epigenome-wide association study of triglyceride
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postprandial responses to a high-fat dietary challenge. J Lipid Res. 2016;57:2200-2207.
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75. Chami N, Chen MH, Slater AJ, Eicher JD, Evangelou E, Tajuddin SM, Love-Gregory L,
Kacprowski T, Schick UM, Nomura A, Giri A, Lessard S, Brody JA, Schurmann C, Pankratz N,
Yanek LR, Manichaikul A, Pazoki R, Mihailov E, Hill WD, Raffield LM, Burt A, Bartz TM,
Becker DM, Becker LC, Boerwinkle E, Bork-Jensen J, Bottinger EP, O'Donoghue ML, Crosslin
DR, de Denus S, Dubé MP, Elliott P, Engström G, Evans MK, Floyd JS, Fornage M, Gao H,
Greinacher A, Gudnason V, Hansen T, Harris TB, Hayward C, Hernesniemi J, Highland HM,
Hirschhorn JN, Hofman A, Irvin MR, Kähönen M, Lange E, Launer LJ, Lehtimäki T, Li J,
Liewald DC, Linneberg A, Liu Y, Lu Y, Lyytikäinen LP, Mägi R, Mathias RA, Melander O,
Metspalu A, Mononen N, Nalls MA, Nickerson DA, Nikus K, O'Donnell CJ, Orho-Melander M,
Pedersen O, Petersmann A, Polfus L, Psaty BM, Raitakari OT, Raitoharju E, Richard M, Rice
KM, Rivadeneira F, Rotter JI, Schmidt F, Smith AV, Starr JM, Taylor KD, Teumer A, Thuesen
BH, Torstenson ES, Tracy RP, Tzoulaki I, Zakai NA, Vacchi-Suzzi C, van Duijn CM, van Rooij
FJ, Cushman M, Deary IJ, Velez Edwards DR, Vergnaud AC, Wallentin L, Waterworth DM,
White HD, Wilson JG, Zonderman AB, Kathiresan S, Grarup N, Esko T, Loos RJ, Lange LA,
Faraday N, Abumrad NA, Edwards TL, Ganesh SK, Auer PL, Johnson AD, Reiner AP, Lettre G.
Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. Am J
Hum Genet. 2016;99:8-21. PMC5005438
76. Ma Y, Follis JL, Smith CE, Tanaka T, Manichaikul AW, Chu AY, Samieri C, Zhou X, Guan W,
Wang L, Biggs ML, Chen YD, Hernandez DG, Borecki I, Chasman DI, Rich SS, Ferrucci L,
Irvin MR, Aslibekyan S, Zhi D, Tiwari HK, Claas SA, Sha J, Kabagambe EK, Lai CQ, Parnell
LD, Lee YC, Amouyel P, Lambert JC, Psaty BM, King IB, Mozaffarian D, McKnight B,
Bandinelli S, Tsai MY, Ridker PM, Ding J, Mstat KL, Liu Y, Sotoodehnia N, Barberger-Gateau
P, Steffen LM, Siscovick DS, Absher D, Arnett DK, Ordovás JM, Lemaitre RN. Interaction of
methylation-related genetic variants with circulating fatty acids on plasma lipids: a meta-analysis
of 7 studies and methylation analysis of 3 studies in the Cohorts for Heart and Aging Research in
Genomic Epidemiology consortium. Am J Clin Nutr. 2016;103:567-78. PMC5260796.
77. Aslibekyan S, Do AN, Xu H; Li S, Irvin MR, Zhi D, Tiwari HK, Absher DM, Shuldiner AR,
Zhang T, Chen W, Tanner K, Hong C, Mitchell BD, Berenson G, Arnett DK. CPT1A
methylation is associated with plasma adiponectin. Nutr Metab Cardiovasc Dis. 2017;27:225-
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78. Mendelson MM, Marioni RE, Joehanes R, Liu C, K. Hedman AK, Aslibekyan S, Demerath EW,
Guan W, Zhi D, Yao C, Huan T, Willinger C, Chen B, Courchesne P, Multhaup M, Irvin MR,
Cohain A, Schadt EE, Grove ML, Bressler J, North K, Sundstrom J, Gustafsson S, Shah S,
McRae AF, Harris SE, Gibson J, Redmond P, Corley J, Murphy L, Starr JM, Kleinbrink E,
Lipovich L, Visscher PM, Wray NR, Krauss RM, Fallin D, Feinberg A, Absher DM, Fornage M,
Pankow JS, Lind L, Fox C, Ingelsson E, Arnett DK, Boerwinkle E, Liang L, Levy D, Deary IJ.
Association of Body Mass Index with DNA Methylation and Gene Expression in Blood Cells
and Relations to Cardiometabolic Disease: A Mendelian Randomization Approach. PloS One.
2017;14:e1002215. PMC5240936.
79. Hedman ÅK, Mendelson MM, Marioni RE, Gustafsson S, Joehanes R, Irvin MR, Zhi D,
Sandling JK, Yao C, Liu C, Liang L, Huan T, McRae AF, Demissie S, Shah S, Starr JM, Cupples
LA, Deloukas P, Spector TD, Sundström J, Krauss RM, Arnett DK, Deary IJ, Lind L, Levy D,
Ingelsson E. Epigenetic Patterns in Blood Associated With Lipid Traits Predict Incident
Coronary Heart Disease Events and Are Enriched for Results From Genome-Wide Association
Studies. Circ Cardiovasc Genet. 2017;10. pii: e001487. PMC5331877.
Ryan Irvin CV • January 2017 • 16
80. Shendre A, Wiener H, Irvin MR, Zhi D, Limdi NA, Overton ET, Wassel CL, Divers J, Rotter JI,
Post WS, Shrestha S. Admixture Mapping of Subclinical Atherosclerosis and Subsequent
Clinical Events Among African Americans in 2 Large Cohort Studies. Circ Cardiovasc Genet.
2017;10. pii: e001569. PMC5396391.
81. Shendre A, Irvin MR, Wiener H, Zhi D, Limdi NA, Overton ET, Shrestha S. Local Ancestry and
Clinical Cardiovascular Events Among African Americans From the Atherosclerosis Risk in
Communities Study. J Am Heart Assoc. 2017;6(4). pii: e004739. PMC5532995
82. Naik RP+, Irvin MR+, Judd S, Gutiérrez OM, Zakai NA, Derebail VK, Peralta C, Lewis MR,
Zhi D, Arnett D, McClellan W, Wilson JG, Reiner AP, Kopp JB, Winkler CA, Cushman M.
Sickle Cell Trait and the Risk of ESRD in Blacks. J Am Soc Nephrol. 2017. pii:
ASN.2016101086. PMC5491293.
83. Bress AP, Irvin MR, Muntner P. Genetics of Blood Pressure: New Insights Into a Complex
Trait. Am J Kidney Dis. 2017;69:723-725. PMC in process.
84. Ng MCY, Graff M, Lu Y, Justice AE, Mudgal P, Liu CT, Young K, Yanek LR, Feitosa MF,
Wojczynski MK, Rand K, Brody JA, Cade BE, Dimitrov L, Duan Q, Guo X, Lange LA, Nalls
MA, Okut H, Tajuddin SM, Tayo BO, Vedantam S, Bradfield JP, Chen G, Chen WM, Chesi A,
Irvin MR, Padhukasahasram B, Smith JA, Zheng W, Allison MA, Ambrosone CB, Bandera EV,
Bartz TM, Berndt SI, Bernstein L, Blot WJ, Bottinger EP, Carpten J, Chanock SJ, Chen YI,
Conti DV, Cooper RS, Fornage M, Freedman BI, Garcia M, Goodman PJ, Hsu YH, Hu J, Huff
CD, Ingles SA, John EM, Kittles R, Klein E, Li J, McKnight B, Nayak U, Nemesure B, Ogunniyi
A, Olshan A, Press MF, Rohde R, Rybicki BA, Salako B, Sanderson M, Shao Y, Siscovick DS,
Stanford JL, Stevens VL, Stram A, Strom SS, Vaidya D, Witte JS, Yao J, Zhu X, Ziegler RG,
Zonderman AB, Adeyemo A, Ambs S, Cushman M, Faul JD, Hakonarson H, Levin AM,
Nathanson KL, Ware EB, Weir DR, Zhao W, Zhi D; Bone Mineral Density in Childhood Study
(BMDCS) Group., Arnett DK, Grant SFA, Kardia SLR, Oloapde OI, Rao DC, Rotimi CN, Sale
MM, Williams LK, Zemel BS, Becker DM, Borecki IB, Evans MK, Harris TB, Hirschhorn JN,
Li Y, Patel SR, Psaty BM, Rotter JI, Wilson JG, Bowden DW, Cupples LA, Haiman CA, Loos
RJF, North KE. Discovery and fine-mapping of adiposity loci using high density imputation of
genome-wide association studies in individuals of African ancestry: African Ancestry
Anthropometry Genetics Consortium. PLoS Genet. 2017;13:e1006719. PMC5419579.
85. Aslibekyan S, Irvin MR, Hidalgo BA, Perry RT, Jeyarajah EJ, Garcia E, Shalaurova I, Hopkins
PN, Province MA, Tiwari HK, Ordovas JM, Absher DM, Arnett DK. Genome- and CD4+ T-cell
methylome-wide association study of circulating trimethylamine-N-oxide in the Genetics of
Lipid Lowering Drugs and Diet Network (GOLDN). J Nutr Intermed Metab. 2017;8:1-7.
PMC5400362.
86. Fernández-Rhodes L, Gong J, Haessler J, Franceschini N, Graff M, Nishimura KK, Wang Y,
Highland HM, Yoneyama S, Bush WS, Goodloe R, Ritchie MD, Crawford D, Gross M, Fornage
M, Buzkova P, Tao R, Isasi C, Avilés-Santa L, Daviglus M, Mackey RH, Houston D, Gu CC,
Ehret G, Nguyen KH, Lewis CE, Leppert M, Irvin MR, Lim U, Haiman CA, Le Marchand L,
Schumacher F, Wilkens L, Lu Y, Bottinger EP, Loos RJL, Sheu WH, Guo X, Lee WJ, Hai Y,
Hung YJ, Absher D, Wu IC, Taylor KD, Lee IT, Liu Y, Wang TD, Quertermous T, Juang JJ,
Rotter JI, Assimes T, Hsiung CA, Chen YI, Prentice R, Kuller LH, Manson JE, Kooperberg C,
Smokowski P, Robinson WR, Gordon-Larsen P, Li R, Hindorff L, Buyske S, Matise TC, Peters
U, North KE. Trans-ethnic fine-mapping of genetic loci for body mass index in the diverse
ancestral populations of the Population Architecture using Genomics and Epidemiology (PAGE)
Study reveals evidence for multiple signals at established loci. Hum Genet. 2017;136:771-800.
PMC5485655.
87. Owolabi M, Sarfo F, Howard VJ, Irvin MR, Gebregziabher M, Akinyemi R, Bennett A,
Armstrong K, Tiwari HK, Akpalu A, Wahab KW, Owolabi L, Fawale B, Komolafe M, Obiako
Ryan Irvin CV • January 2017 • 17
R, Adebayo P, Manly JM, Ogbole G, Melikam E, Laryea R, Saulson R, Jenkins C, Arnett DK,
Lackland DT, Ovbiagele B, Howard G; SIREN-REGARDS Collaboration (Stroke Investigative
Research and Educational Network–Reasons for Geographic and Racial Differences in Stroke).
Stroke in Indigenous Africans, African Americans, and European Americans: Interplay of Racial
and Geographic Factors. Stroke. 2017;48:1169-1175. PMC5404953.
88. Katz DH, Deo RC, Aguilar FG, Selvaraj S, Martinez EE, Beussink-Nelson L, Kim KA, Peng J,
Irvin MR, Tiwari H, Rao DC, Arnett DK, Shah SJ. Phenomapping for the Identification of
Hypertensive Patients with the Myocardial Substrate for Heart Failure with Preserved Ejection
Fraction. J Cardiovasc Transl Res. J Cardiovasc Transl Res. 2017 Jun;10(3):275-284. PMC in
process.
89. Sayols-Baixeras S, Irvin MR, Arnett DK, Elosua R, Aslibekyan SW. Epigenetics of Lipid
Phenotypes. Curr Cardiovasc Risk Rep. 2016;10. pii: 31. PMC5421987.
90. Vemulapalli S, Deng L, Patel MR, Kilgore ML, Jones WS, Curtis LH, Irvin MR, Svetkey LP,
Shimbo D, Calhoun DA, Muntner P. National patterns in intensity and frequency of outpatient
care for apparent treatment-resistant hypertension. Am Heart J. 2017;186:29-39. PMC in process.
91. Wild PS, Felix JF, Schillert A, Teumer A, Chen MH, Leening MJG, Völker U, Großmann V,
Brody JA, Irvin MR, Shah SJ, Pramana S, Lieb W, Schmidt R, Stanton AV, Malzahn D, Smith
AV, Sundström J, Minelli C, Ruggiero D, Lyytikäinen LP, Tiller D, Smith JG, Monnereau C, Di
Tullio MR, Musani SK, Morrison AC, Pers TH, Morley M, Kleber ME, Aragam J, Benjamin EJ,
Bis JC, Bisping E, Broeckel U, Cheng S, Deckers JW, Del Greco M F, Edelmann F, Fornage M,
Franke L, Friedrich N, Harris TB, Hofer E, Hofman A, Huang J, Hughes AD, Kähönen M,
Investigators K, Kruppa J, Lackner KJ, Lannfelt L, Laskowski R, Launer LJ, Leosdottir M, Lin
H, Lindgren CM, Loley C, MacRae CA, Mascalzoni D, Mayet J, Medenwald D, Morris AP,
Müller C, Müller-Nurasyid M, Nappo S, Nilsson PM, Nuding S, Nutile T, Peters A, Pfeufer A,
Pietzner D, Pramstaller PP, Raitakari OT, Rice KM, Rivadeneira F, Rotter JI, Ruohonen ST,
Sacco RL, Samdarshi TE, Schmidt H, Sharp ASP, Shields DC, Sorice R, Sotoodehnia N, Stricker
BH, Surendran P, Thom S, Töglhofer AM, Uitterlinden AG, Wachter R, Völzke H, Ziegler A,
Münzel T, März W, Cappola TP, Hirschhorn JN, Mitchell GF, Smith NL, Fox ER, Dueker ND,
Jaddoe VWV, Melander O, Russ M, Lehtimäki T, Ciullo M, Hicks AA, Lind L, Gudnason V,
Pieske B, Barron AJ, Zweiker R, Schunkert H, Ingelsson E, Liu K, Arnett DK, Psaty BM,
Blankenberg S, Larson MG, Felix SB, Franco OH, Zeller T, Vasan RS, Dörr M. Large-scale
genome-wide analysis identifies genetic variants associated with cardiac structure and function. J
Clin Invest. 2017;127:1798-1812. PMC5409098.
92. Liu N, Irvin MR, Zhi D, Patki A, Beasley TM, Nickerson DA, Hill CE, Chen J, Kimmel SE,
Limdi NA. Influence of common and rare genetic variation on warfarin dose among African-
Americans and European-Americans using the exome array. Pharmacogenomics. 2017
Jul;18(11):1059-1073. PMC5619051
93. Tanner RM, Shimbo D, Irvin MR, Spruill TM, Bromfield SG, Seals SR, Young BA, Muntner P.
Chronic kidney disease and incident apparent treatment-resistant hypertension among blacks:
Data from the Jackson Heart Study. J Clin Hypertens (Greenwich). 2017 Nov;19(11):1117-1124.
PMC5693725
94. Akinyemi R, Arnett DK, Tiwari HK, Ovbiagele B, Sarfo F, Srinivasasainagendra V, Irvin MR,
Adeoye A, Perry RT, Akpalu A, Jenkins C, Owolabi L, Obiako R, Wahab K, Sanya E, Komolafe
M, Fawale M, Adebayo P, Osaigbovo G, Sunmonu T, Olowoyo P, Chukwuonye I, Obiabo Y,
Akpa O, Melikam S, Saulson R, Kalaria R, Ogunniyi A, Owolabi M; SIREN Investigators.
Interleukin-6 (IL-6) rs1800796 and cyclin dependent kinase inhibitor (CDKN2A/CDKN2B)
rs2383207 are associated with ischemic stroke in indigenous West African Men. J Neurol Sci.
2017 Aug 15;379:229-235. PMC5546618
Ryan Irvin CV • January 2017 • 18
95. Selvaraj S, Djoussé L, Aguilar FG, Martinez EE, Polsinelli VB, Irvin MR, Arnett DK, Shah SJ. Association of Estimated Sodium Intake With Adverse Cardiac Structure and Function: From the
HyperGEN Study. J Am Coll Cardiol. 2017 Aug 8;70(6):715-724. PMC5571737
96. Kent ST, Rosenson RS, Avery CL, Chen YI, Correa A, Cummings SR, Cupples LA, Cushman
M, Evans DS, Gudnason V, Harris TB, Howard G, Irvin MR, Judd SE, Jukema JW, Lange L,
Levitan EB, Li X, Liu Y, Post WS, Postmus I, Psaty BM, Rotter JI, Safford MM, Sitlani CM,
Smith AV, Stewart JD, Trompet S, Sun F, Vasan RS, Woolley JM, Whitsel EA, Wiggins KL,
Wilson JG, Muntner P. PCSK9 Loss-of-Function Variants, Low-Density Lipoprotein
Cholesterol, and Risk of Coronary Heart Disease and Stroke: Data From 9 Studies of Blacks and
Whites. Circ Cardiovasc Genet. 2017 Aug;10(4):e001632. PMC in process
97. Raffield LM, Zakai NA, Duan Q, Laurie C, Smith JD, Irvin MR, Doyle MF, Naik RP, Song C,
Manichaikul AW, Liu Y, Durda P, Rotter JI, Jenny NS, Rich SS, Wilson JG, Johnson AD,
Correa A, Li Y, Nickerson DA, Rice K, Lange EM, Cushman M, Lange LA, Reiner AP; NHLBI
Trans-Omics for Precision Medicine (TOPMed) Consortium, Hematology & Hemostasis
TOPMed Working Group*. D-Dimer in African Americans: Whole Genome Sequence Analysis
and Relationship to Cardiovascular Disease Risk in the Jackson Heart Study. Arterioscler
Thromb Vasc Biol. 2017 Nov;37(11):2220-2227. PMC5658238
98. Akinyemi R, Tiwari HK, Arnett DK, Ovbiagele B, Irvin MR, Wahab K, Sarfo F,
Srinivasasainagendra V, Adeoye A, Perry RT, Akpalu A, Jenkins C, Arulogun O, Gebregziabher
M, Owolabi L, Obiako R, Sanya E, Komolafe M, Fawale M, Adebayo P, Osaigbovo G, Sunmonu
T, Olowoyo P, Chukwuonye I, Obiabo Y, Onoja A, Akinyemi J, Ogbole G, Melikam S, Saulson
R, Owolabi M; SIREN Investigators. APOL1, CDKN2A/CDKN2B, and HDAC9
polymorphisms and small vessel ischemic stroke. Acta Neurol Scand. 2018 Jan;137(1):133-141.
PMC5716854
99. Yanik MV, Irvin MR, Beasley TM3, Jacobson PA, Julian BA, Limdi NA. Influence of Kidney
Transplant Status on Warfarin Dose, Anticoagulation Control, and Risk of Hemorrhage.
Pharmacotherapy. 2017 Nov;37(11):1366-1373. PMC5681429
100. Mefford MT, Rosenson RS, Cushman M, Farkouh ME, McClure LA, Wadley VG, Irvin MR,
Bittner VA, Safford MM, Somaratne R, Monda KL, Muntner P, Levitan EB. PCSK9 Variants,
LDL-Cholesterol, and Neurocognitive Impairment: The REasons for Geographic and Racial
Differences in Stroke (REGARDS) Study. Circulation. 2017 Nov 16. pii:
CIRCULATIONAHA.117.029785. PMC in process
101. Richard MA, Huan T, Ligthart S, Gondalia R, Jhun MA, Brody JA, Irvin MR, Marioni R, Shen
J, Tsai PC, Montasser ME, Jia Y, Syme C, Salfati EL, Boerwinkle E, Guan W, Mosley TH Jr,
Bressler J, Morrison AC, Liu C, Mendelson MM, Uitterlinden AG, van Meurs JB; Franco OH,
Zhang G, Li Y, Stewart JD, Bis JC, Psaty BM, Chen YI, Kardia SLR, Zhao W, Turner ST,
Absher D, Aslibekyan S, Starr JM, McRae AF, Hou L, Just AC, Schwartz JD, Vokonas PS,
Menni C, Spector TD, Shuldiner A, Damcott CM, Rotter JI, Palmas W, Liu Y, Paus T, Horvath
S, O'Connell JR, Guo X, Pausova Z, Assimes TL, Sotoodehnia N, Smith JA, Arnett DK, Deary
IJ, Baccarelli AA, Bell JT, Whitsel E, Dehghan A, Levy D, Fornage M. DNA Methylation
Analysis Identifies Loci for Blood Pressure Regulation. Am J Hum Genet. 2017 Dec
7;101(6):888-902. doi: 10.1016/j.ajhg.2017.09.028.
102. Owolabi M, Peprah E, Xu H, Akinyemi R, Tiwari HK, Irvin MR, Wahab KW, Arnett DK,
Ovbiagele B. Advancing stroke genomic research in the age of Trans-Omics big data science:
Emerging priorities and opportunities. J Neurol Sci. 2017 Nov 15;382:18-28. doi:
10.1016/j.jns.2017.09.021.
103. Huisingh C, Levitan EB, Irvin MR, MacLennan P, Wadley V, Owsley C. Visual Sensory and
Visual-Cognitive Function and Rate of Crash and Near-Crash Involvement Among Older Drivers
Using Naturalistic Driving Data. Invest Ophthalmol Vis Sci. 2017 Jun 1;58(7):2959-2967.
Ryan Irvin CV • January 2017 • 19
104. Yusuf N, Hidalgo B, Irvin MR, Sha J, Zhi D, Tiwari HK, Absher D, Arnett DK, Aslibekyan S.
An epigenome-wide association study of inflammatory response to fenofibrate in the Genetics of
Lipid Lowering Drugs and Diet Network. Pharmacogenomics. 2017 Sep;18(14):1333-1341. doi:
10.2217/pgs-2017-0037.
105. Shendre A, Wiener HW, Irvin MR, Aouizerat BE, Overton ET, Lazar J, Liu C, Hodis HN,
Limdi NA, Weber KM, Gange SJ, Zhi D, Floris-Moore MA, Ofotokun I, Qi Q, Hanna DB,
Kaplan RC, Shrestha S. Genome-wide admixture and association study of subclinical
atherosclerosis in the Women's Interagency HIV Study (WIHS). PLoS One. 2017 Dec
4;12(12):e0188725. PMC in process
106. Irvin MR, Booth JN, Sims M, Bress AP, Abdalla M, Shimbo D, Calhoun D, Muntner P. The
association of nocturnal hypertension and non-dipping blood pressure with treatment resistant
hypertension: The Jackson Heart Study. The Journal of Clinical Hypertension. 2017 In Press
107. Do AN, Zhao W, Srinivasasainagendra V, Aslibekyan S, Tiwari HK, Limdi N, Shah SJ, Zhi D,
Broeckel U, Gu CC, Rao DC, Schwander K, Smith JA, Kardia S, Arnett DK , Irvin MR. Whole
Exome Analyses to Examine the Impact of Rare Variants on Left Ventricular Traits in African
American Participants from the HyperGEN and GENOA Studies. J Hypertens Manag 2017,
3:025 DOI: 10.23937/2474-3690/1510025
108. Malik R et al. AFGen Consortium; Cohorts for Heart and Aging Research in Genomic
Epidemiology (CHARGE) Consortium; International Genomics of Blood Pressure (iGEN-BP)
Consortium; INVENT Consortium; STARNET; BioBank Japan Cooperative Hospital Group;
COMPASS Consortium; EPIC-CVD Consortium; EPIC-InterAct Consortium; International
Stroke Genetics Consortium (ISGC); METASTROKE Consortium; Neurology Working Group
of the CHARGE Consortium; NINDS Stroke Genetics Network (SiGN); UK Young Lacunar
DNA Study; MEGASTROKE Consortium; MEGASTROKE Consortium:. Multi-ancestry
genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and
stroke subtypes. Nat Genet. 2018 Apr;50(4):524-537. doi: 10.1038/s41588-018-0058-3
109. Geng X, Irvin MR, Hidalgo B, Aslibekyan S, Srinivasasainagendra V, An P, Frazier-Wood AC,
Tiwari HK, Dave T, Ryan K, Ordovas JM, Straka RJ, Feitosa MF, Hopkins PN, Borecki I,
Province MA, Mitchell BD, Arnett DK, Zhi D. An exome-wide sequencing study of lipid
response to high-fat meal and fenofibrate in Caucasians from the GOLDN cohort. J Lipid Res.
2018 Apr;59(4):722-729. doi: 10.1194/jlr.P080333.
110. Booth JN III, Li M, Shimbo D, Hess R, Irvin MR, Kittles R, Wilson JG, Jorde L, Cheung A,
Lange L, Lange E, Yano T, Muntner P, Bress AP. West African ancestry and nocturnal blood
pressure in African Americans: the Jackson Heart Study. Am J Hypertens. 2018 May
7;31(6):706-714. doi: 10.1093/ajh/hpy038.
111. Akinyemiju T, Do AN, Patki A, Aslibekyan S, Zhi D, Hidalgo B, Tiwari HK, Absher D, Geng
X, Arnett DK, Irvin MR. Epigenome-wide association study of metabolic syndrome in African-
American adults. Clin Epigenetics. 2018 Apr 10;10:49. doi: 10.1186/s13148-018-0483-2
112. Irvin MR, Aslibekyan S, Do A, Zhi D, Hidalgo B, Claas SA, Srinivasasainagendra V, Horvath
S, Tiwari HK, Absher DM, Arnett DK. Metabolic and inflammatory biomarkers are associated
with epigenetic aging acceleration estimates in the GOLDN study. Clin Epigenetics. 2018 Apr
18;10:56. doi: 10.1186/s13148-018-0481-4.
113. Irvin MR, Sitlani CM, Noordam R, Avery CL, Bis JC, Floyd JS, Li J, Limdi NA,
Srinivasasainagendra V, Stewart J, de Mutsert R, Mook-Kanamori DO, Lipovich L, Kleinbrink
EL, Smith A, Bartz TM, Whitsel EA, Uitterlinden AG, Wiggins KL, Wilson JG, Zhi D, Stricker
BH, Rotter JI, Arnett DK, Psaty BM, Lange LA. Genome-wide meta-analysis of SNP-by9-
ACEI/ARB and SNP-by-thiazide diuretic and effect on serum potassium in cohorts of European
and African ancestry. Pharmacogenomics J. 2018 Jun 1. doi: 10.1038/s41397-018-0021-9
Ryan Irvin CV • January 2017 • 20
114. Gutiérrez OM, Irvin MR, Chaudhary NS, Cushman M, Zakai NA, David VA, Limou S, Pamir
N, Reiner AP, Naik RP, Sale MM, Safford MM, Hyacinth HI, Judd SE, Kopp JB, Winkler CA.
APOL1 nephropathy risk variants and incident cardiovascular disease events in community-
dwelling Black adults. Circ Genom Precis Med. 2018 Jun;11(6):e002098. doi:
10.1161/CIRCGEN.117.002098
115. de Oliveira Otto MC, Lemaitre RN, Sun Q, King IB, Wu JHY, Manichaikul A, Rich SS, Tsai
MY, Chen YD, Fornage M, Weihua G, Aslibekyan S, Irvin MR, Kabagambe EK, Arnett DK,
Jensen MK, McKnight B, Psaty BM, Steffen LM, Smith CE, Risérus U, Lind L, Hu FB, Rimm
EB, Siscovick DS, Mozaffarian D. Genome-wide association meta-analysis of circulating odd-
numbered chain saturated fatty acids: results from the CHARGE Consortium. PLoS One. 2018
May 8;13(5):e0196951. doi: 10.1371/journal.pone.0196951
Book Chapters
1. Padilla MA, Irvin MR, Tiwari HK. Gene-environment Interactions: Gene-environment
interactions in human traits in Nriagu J (ed) Encyclopedia on Environmental Health, Elsevier
Science, 2011.
2. Irvin MR. Genetics of complex traits in Shah SJ, Arnett DK (eds) Cardiovascular
Genetics and Genomics in Clinical Practice, Demos Medical, 2014.
Abstracts and Posters
1. Dickson MR, Go R CP, Wiener H, Blacker D, Bassett SS. A genomic scan for age at onset
of Alzheimer’s disease from the NIMH Genetic Initiative. Poster Presentation at Annual
International Genetic Epidemiology Society Meeting. November 2006, Tampa Bay, FL.
2. Dickson MR, Wiener HW, Perry RP, Go R CP. Genetic risk factors for type 2 diabetes with
pharmacologic intervention in patients with schizophrenia and schizoaffective disorder.
Poster Presentation at Genome-wide Association: Analyze This! August 2008, Bethesda,
MD.
3. Irvin MR, Lynch AI, Kabagambe EK, Tiwari HK , Barzilay JI, Eckfeldt J, Boerwinkle E,
Davis BR, Ford CE, Arnett DK. Pharmacogenetic association of hypertension candidate
genes with fasting glucose in the GenHAT Study. Poster Presentation, American Heart
Association Cardiovascular Disease Epidemiology and Prevention Conference. March 3-5th
2010, San Francisco, CA.
4. Irvin MR, Wineinger N, Pajewski NM, Kabagambe EK, Gu CC, Pankow J, North KE, Wilk
JB, Freedman B, Franceschini N, Tiwari HK, Arnett DK. Genome wide detection of allele
specific copy number variation associated with diabetes related traits in African Americans
from the HyperGEN Study. Poster Presentation, HudsonAlpha Spring Symposium. March
30th 2010, Hunstville, AL.
5. Irvin MR, Kabagambe EK, Zhang Q, Sha J, Tiwari HK, Borecki IB, Province MA, Shimmin
LC, Hixson JE, and Arnett DK. Rare PPARa variants and extreme response to fenofibrate in
the GOLDN Study. Poster Presentation, Evolution of Next-Generation Sequencing Data
Management Workshop. September 27-29th 2010, Providence, RI.
6. Irvin MR, Kabagambe EK, Zhang Q, Sha J, Tiwari HK, Borecki IB, Province MA, Shimmin
LC, Hixson JE, and Arnett DK.. Rare PPARa variants and extreme response to fenofibrate in
the GOLDN Study. Poster Presentation at the 51th annual American Heart Association
Cardiovascular Disease Epidemiology and Prevention Conference. March 23-25th 2011,
Atlanta, GA.
Ryan Irvin CV • January 2017 • 21
7. Irvin MR, Wood AC, Vaughn LK, Kabagambe EK, Sha J, Tiwari HK, Borecki IB, Ordovas
JM, Arnett DK. Genetics of Insulin Response to Fenofibrate in the GOLDN Study. Poster
Presentation, AHA Scientific Sessions. Nov 12-15 2011, Orlando, FL.
8. Arnett DK, Borecki IB, Irvin MR, Tiwari HK, Straka RJ, Ordovas JM. Genome-Wide
Association Study of Lipid Response to Fenofibrate Treatment in the Genetics of Lipid-
Lowering Drugs and Diet Network (GOLDN) Study. Nutrition, Physical Activity and
Metabolism / Cardiovascular Disease Epidemiology and Prevention Scientific Sessions,
March 2012, San Diego, CA.
9. Aguilar FG, Selvaraj S, Martinez EE, Kim KA, Peng J, Rasmussen-Torvik L, Sha J, Irvin
MR, Arnett DK, Shah DJ. Serum Uric Acid is an Independent Risk Factor for Subclinical
Cardiac Dysfunction: A Speckle- Tracking Analysis of the HyperGEN Study. Abstract
Oral Session, AHA Scientific Sessions. Nov 7 2012. Los Angeles, CA.
10. Shah SJ, Aguilar FG, Selvaraj S, Martinez EE, Kim KA, Peng J, Rasmussen-Torvik L,
Sha J, Irvin MR, Budinger S, Mutlu GM, Arnett DK. Adverse Effects of Obesity,
Hyperglycemia, and Insulin Resistance on Cardiac Mechanics. Abstract Oral Session,
American Heart Association Scientific Sessions. Nov 7 2012, Los Angeles, CA.
11. Selvaraj S, Aguilar FG, Martinez EE, Kim KA, Peng J, Rasmussen-Torvik L, Sha J, Irvin
MR, Arnett DK, Shah SJ. Diastolic Wall Strain: A Simple Marker of Abnormal Cardiac
Mechanics. Poster Presentation, American Heart Association Scientific Sessions. Nov 5
2012, Los Angeles, CA.
12. Irvin MR, Booth JN, Shimbo D, Lackland DT, Oparil S, Howard G, Safford M, Muntner P,
Calhoun DA. Apparent Treatment Resistant Hypertension and Risk for Stroke, Coronary
Heart Disease and All-cause Mortality. Poster Presentation, American Heart Association
EPI/NPAM March 2013 New Orleans, LA.
13. Tanner RM, Calhoun DA, Bell EK, Bowling CB, Gutiérrez OM, Irvin MR, Lackland DT,
Oparil S, Warnock D, Muntner, P. Prevalence of aTRH among individuals with CKD: results
from the REGARDS study. Moderated Poster Presentation, American Heart Association
EPI/NPAM March 2013 New Orleans, LA.
14. Katz DH, Selvaraj S, Aguilar F, Martinez E, Beussink L, Kim K, Peng J, Sha J, Irvin MR,
Freedman B, Eckfeldt J, Arnett DK, Shah S. Association of Albuminuria with Adverse
Cardiac Mechanics: Findings from the HyperGEN Study. Poster Presentation, American
College of Cardiology March 2013, San Francisco, CA.
15. Aslibekyan S, Irvin MR, Sha J, Zhi D, Thibeault KS, Tsai M, Hopkins P, Borecki IB,
Ordovas JM, Absher D, Arnett DK. CPT1A Methylation is a Novel Epigenetic Marker of
Cardiovascular Risk. Oral Presentation, AHA Emerging Science Series, June 19, 2013,
Dallas, TX.
16. Howard VJ, Tanner RM, Irvin MR, Calhoun DA, Anderson A, Lackland DT, Oparil S,
Muntner P. Prevalence and Predictors of Apparent Treatment-Resistant Hypertension among
Individuals with a History of Physician-Diagnosed Stroke or TIA. Oral Presentation,
American Heart Association/American Stroke Association International Stroke Conference,
Feb 2014, San Diego, CA.
17. Diaz KM, Booth JN, Calhoun DA, Irvin MR, Howard G, Safford MM, Muntner P, Shimbo D.
Association of healthy lifestyle factors with all-cause mortality and incident cardiovascular
events among individuals with apparent treatment resistant hypertension: the Reasons for
Geographic And Racial Differences in Stroke (REGARDS) study. Moderated Poster
Presentation, American Heart Association EPI/NPAM March 2014 San Francisco, CA.
Ryan Irvin CV • January 2017 • 22
18. Bromfield S, Shimbo D, Diaz K, Booth J, Calhoun D, Irvin MR, Krousel-Wood M,
Redmond N, Oparil S, Muntner P. The associations between apparent treatment resistant
hypertension and low mental and physical functioning, depressive symptoms, and stress.
Poster Presentation, American Heart Association EPI/NPAM March 2014 San Francisco,
CA.
19. Aslibekyan S, Hidalgo B, Irvin MR, Sha J, Tiwari HK, Zhi D, Ordovas JM, Absher D,
Arnett DK. Epigenome-wide study of erythrocyte fatty acids in the Genetics of Lipid
Lowering Drugs and Diet Network. Poster Presentation, American Heart Association
EPI/NPAM March 2014 San Francisco, CA.
20. Hidalgo B, Irvin MR, Aslibekyan S, Sha J, Zhi D, Ordovas JM, Absher D, Tiwari HK,
Arnett DK. Epigenome-wide association study of lipid and inflammatory marker response
fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network Study. Moderated
Poster Presentation, American Heart Association EPI/NPAM March 2014 San Francisco,
CA.
21. Irvin, MR; Zhi, D; Limdi, NA; Sitlani, CM; Floyd, JS; Avery, CL; Musani, SK; Smith, AV;
Noordam, R; Arnett, DK on behalf of the CHARGE Pharmacogenetics Working Group.
Genome-Wide Meta-analysis of SNP-by-Thiazide diuretic and SNP-by-ACEI/ARB effect on
serum potassium in cohorts of European and African Ancestry in CHARGE. Winter
CHARGE Conference, November 2014, Washington DC.
22. Kent ST, Rosenson RS, Avery CL, Correa A, Cummings SR, Cupples LA, Cushman M, ,
Evans DS, Gudnason V, Harris TB, Howard G, Irvin MR, Judd SE, Jukema JW, Lange L,
Emily B Levitan EB, Li X, Liu Y, Postmus I, Psaty BM, Rotter JI, Safford MM, Sitlani CM,
Smith AV, Stewart JD, Trompet S, Sun F, Vasan RS, Woolley JM, Whitsel EA, Wiggins KL,
Wilson JG, Muntner P. PCSK9 Loss-of-function Variants, Low-density Lipoprotein
Cholesterol, And Risk Of Coronary Heart Disease And Stroke: Data From The REGARDS
Study And CHARGE Consortium. Oral presentation. American Heart Association Scientific
Sessions November 2015, Orlando, FL.
23. Vemulapalli S, Deng L, Patel MR, Kilgore ML, Jones WS, Curtis LH, Irvin MR, Svetkey
LP; Shimbo D, Calhoun DA, Muntner P. National Patterns in Intensity and Frequency of
Outpatient Care for Apparent Treatment Resistant Hypertension. Poster presentation.
American Heart Association Scientific Sessions November 2015, Orlando, FL.
24. Irvin MR, Zhi D, Limdi N, Sitlani C, Floyd F, Avery C, Whitsel E, Lange L, Smith A,
Noordam R, Arnett DK. Genome-Wide Meta-analysis of SNP-by-Thiazide diuretic and SNP-
by-ACEI/ARB effect on serum potassium in cohorts of European and African Ancestry in
CHARGE. Moderated Poster presentation. American Heart Association Epi Lifestyle March
2016, Phoenix, AZ.
25. Do AN, Irvin MR, Zhi D, Tiwari HK, Aslibekyan S, Zhao W, Smith J, Rao DC, Claas SA,
Broeckel U, Arnett DK. Epigenetic determinants of left ventricular traits and functions in
hypertensive African Americans. CVGPS special poster session. American Heart
Association Scientific Sessions November 2016, New Orleans LA.
26. Irvin MR, Hidalgo B, Zhi D, Aslibekyan S, Tiwari HK, Absher D, Arnett DK. Epigenetic
Age Acceleration and Postprandial Lipemia in the Genetics of Lipid Lowering Drugs and
Diet Network Study. Poster. EPI/Lifestyle 2017 Scientific Sessions, March 2017, Portland,
OR.
27. Gutiérrez OM+, Irvin MR+, Chaudhary NS, Cushman M, Zakai NA, David VA, Limou S,
Pamir N, Reiner AP, Naik RP, Sale MM, Nelson GW, Safford MM, Hyacinth HI, Judd SE,
Kopp JB, Winkler CA. APOL1 nephropathy risk variants and incident cardiovascular disease
Ryan Irvin CV • January 2017 • 23
events in community-dwelling Black adults ASN Kidney Week 2017 Annual Meeting,
October 31 - November 5 in New Orleans, LA.
28. Jones AC, Irvin MR, Chaudhary NS, Howard VJ, Howard H, Judd SE. Walkability as a
Predictor of Incident Hypertension in a National Cohort Study. UASOM Medical Student
Research Day, Tuesday, August 7, 2018, Birmingham AL. 1st Place Prize Poster
External Research Support
Ongoing
Genetic Underpinnings of Cardiorenal Risk in Africans and African Americans
NIH/NHLBI R01HL13666 (PIs: Irvin and Lange)
African Americans are overburdened by hypertension and related comorbidities, representing a
major area of racial health disparity, with African Americans having higher risk and worse
outcomes. The proposed work will identify novel genetic risk factors for various cardiorenal
measures in African Americans and Africans. The results may help better understand the
potential ancestral genetic etiology and lead to improved disease diagnosis as well as
cardiovascular disease prevention.
Role: Co-PI (4/01/17 – 03/31/2021)
Genomic Background of Blood Pressure Response to Thiazide Diuretic in African
Americans.
NIH/NHLBI 1R01HLHL123782-01 (PI: Irvin)
Hypertension (unhealthy high blood pressure) tends to begin earlier in life in African
Americans and clinical consequences (for example, cardiovascular disease) occur more rapidly.
Thiazide diuretics are the most common treatment for hypertension in this race group, yet some
persons do not respond to the medicine or have adverse metabolic side effects. The proposed
work will identify novel genetic risk factors for response and potentially harmful metabolic
side effects.
Role: Principal Investigator (09/15/2016 – 05/31/2021)
Genomics of lipidomic phenotypes in a postprandial intervention dietary study
15SDG25760020-American Heart Association Scientist Development Grant-National Center
This project will add deeper lipid phenotyping to the well-characterized Genetics of Lipid
Lowering Drugs and Diet Network (GOLDN) study using stored plasma samples. We will then
evaluate the association of the new phenotypes with existing genetic and epigenetic markers to
reveal novel loci underlying lipid metabolism.
Role: Principal Investigator (07/01/2015 – 06/30/2019)
HyperGEN: Genetics of Left Ventricular (LV) Hypertrophy NIH/NHLBI 2R01HL055673-16 (PI: Arnett)
To further understand the genetic architecture of LV hypertrophy and related traits.
Role: Subcontract PI (07/15/2013 – 04/30/2017 NCE)
Determinants, Trajectories, and Consequences of Abnormal Cardiac Mechanics
NIH/NHLBI 2R01HL107577-05 (PI: Shah)
The overall goal of the proposed studies is to leverage a unique ability to digitize and speckle-
track archived echoes from epidemiologic studies with the goal of further understanding
determinants, trajectories, and consequences of abnormal cardiac mechanics.
Role: Subcontract PI (07/05/2016 – 4/30/2020)
Metabolic predictors of stroke in REGARDS
NIH/NINDS 1R01NS099209-01 (PI: Kimberly)
Ryan Irvin CV • January 2017 • 24
There are geographic and racial disparities in the burden of stroke across the United States. In
this proposal, we will apply novel metabolite profiling techniques developed by our group to
test the hypothesis that metabolomics will illuminate stroke-associated markers and unravel
racial differences in that risk. These efforts have the potential to improve our ability to
identify individuals at risk for stroke and improve the understanding of underlying
mechanisms of disease.
Role: Subcontract PI (12/01/2016 – 11/30/2021)
Genomewide Association: Triglyceride Response to Fenofibrate Therapy and Dietary Fat
NIH/NHLBI 5R01HL091357-04 (PI: Arnett)
This study aims to identify genetic variants that influence fat and cholesterol’s response to diet
and drugs.
Role: Subcontract PI (04/01/2015 – 03/31/2019)
Trace Mineral Levels, The Trajectory of Cognitive Decline and Telomere Attrition
NIH/NIA 1R01AG056111 (PI: He)
The overall objective of this project is to examine a few trace mineral concentrations measured
in urine or serum in relation to the trajectory of cognitive decline, as well as telomere length
and telomere attrition. The proposed study will help to identify at-risk Americans for cognitive
decline and/or the consequences of aging. For nutritious minerals, information generated from
this study will be useful for future interventions related to healthy aging; and for the toxic ones
at low-to-moderate exposure level, knowledge gained will serve as a scientific foundation for
remediation and prevention strategies to improve cognitive health or slow down the
consequences of aging.
Role: PI of Subcontract (09/01/2017-08/31/2022)
Identification of the role of HDL function in human cardiovascular disease through
proteomics and genetics
NIH/NHLBI 1R01HL136373-01 (PI: Pamir)
This study will use available genomic data with the REGARDS study to determine genetic
variants responsible for dysfunctional HDL associated with human cardiovascular disease
and/or stroke events.
Role- PI of Subcontract (11/01/2017-08/31/2022)
HyperGEN: Genetics of Left Ventricular (LV) Hypertrophy – TOPMed Supplement NIH/NHLBI 3R01HL055673-18S1 (PI: Arnett)
To further understand the genetic architecture of LV hypertrophy and related traits using whole-
genome sequencing.
Role: Co-Investigator (08/14/2015 – 04/30/2017 NCE)
VCID and Stroke in a Bi-racial National Cohort (REGARDS)
NIH/NINDS 2 U01 NS041588 (PIs: Manly and Howard)
This is a longitudinal cohort study of > 30,000 black and white participants over the age of
45: 21% from the “buckle” of the stroke belt, 35% from the rest of the stroke belt area, and
44% from the remainder of the 40 contiguous states. The aims of the current grant are to: 1)
advance the understanding of disparities in the rate of cognitive decline and the
development of clinically defined cognitive impairment, 2) continue to advance the
understanding of disparities in stroke risk, with particular emphasis on stroke in the elderly,
and 3) assess biomarkers contributing to the disparities in the development of hypertension
and diabetes.
Role: Co-Investigator (09/01/01 – 01/31/23) Transitions to Family Caregiving and the impact on Caregivers’ Health
Ryan Irvin CV • January 2017 • 25
NIH/NINDS R01AG050609-01 (PI: Roth)
The proposed investigation will make major contributions to the research literature on the
health effects of caregiving. We propose to identify and study a large group of individuals who
have transitioned from being non-caregivers into an informal family caregiving role at some
point during their participation in a large, ongoing, national epidemiologic study.
Role- Co-Investigator (04/01/2016-03/31/2021)
Completed
Epigenetic Determinants of Lipid Response to Dietary Fat and Fenofibrate NHLBI 1R01HL104135-01 (PI: Arnett)
Research focuses on genetic and epigenetic response to lipid-lowering treatment with
fenofibrate in the Genetics of Lipid Lowering and Diet Network Study (GOLDN).
Role: Co-Investigator (08/15/2010 – 05/31/2014)
Stroke Investigative Research & Educational Network (SIREN)
NIH/NHGRI 1U54HG007479-01 (PI: Owolabi)
As a key aspect of the Stroke Investigative Research and Education Network (SIREN), the
overall goals of the Systematic Investigation of Blacks with Stroke (SIBS) Genomics project
are to evaluate the premier genetic risk factors for stroke in black Africans, and through
training and mentoring build sustainable cardiovascular genomics expertise/capacity in Sub-
Saharan Africa.
Role: Co-Investigator (08/01/2015 – 07/31/2017)
Epigenetic Determinants of Left Ventricular and Function in Hypertensive African
Americans
American Heart Association CVGPS Pathway (PI: Arnett)
Left ventricular hypertrophy (a thickening of heart walls that can reduce the heart's ability to
pump effectively) is common in African Americans, and it contributes more to the risk of
cardiovascular death in African Americans than it does in other race groups. This project is
designed to determine which non-coding genetic factors (that is, epigenetic factors) may play a
role in the development of left ventricular hypertrophy in African Americans.
Role: Subcontract PI (02/01/2015 – 01/31/2017)
Prospective Meta-Analyses of Drug-Gene Interactions: CHARGE GWAS Consortium
NIH/NHLBI 1R01HL103612-02 (PI: Psaty)
The benefits of modern drug therapies can be maximized by avoiding some medications in
patients who are genetically susceptible to adverse reactions or by selecting other medications
for patients who are genetically likely to benefit. This broad-based discovery effort may help to
illuminate biologic mechanisms, affect how some drugs are prescribed, or identify novel targets
for new therapies.
Role: Subcontract PI (08/10/2011 – 05/31/2015)
UAB CFAR-Lipidomic profiling in HIV patients newly initiating antiretroviral treatments
NIH/NIAID Administrative Supplement to 5P30AI027767-27 (PI: Saag)
Cardiovascular disease (CVD) is the second leading cause of death among people with HIV.
Changes in lipids after starting retroviral treatment may contribute to that statistic. This study
will investigate changes in small-molecule lipids and link those changes to clinical lipids and
measures of CVD risk aiming to better understand mechanisms underlying CVD in HIV+
individuals.
Role: Principal on Supplement (06/30/2015 – 05/31/2016 NCE)
Genetic Variants in Calcium Channel and Binding Proteins Underlying cIMT in HIV
Ryan Irvin CV • January 2017 • 26
NIH/NHLBI 1R56HL125061(PI: Shrestha)
The major objective of this study is to conduct deep-sequencing and examine genetic variants
in 9 genes encoding Ca2+ channels (RYR1, RYR2, RYR3, IP3R) and other related proteins
(GADD153, CALM1, CALM2, CALM3, CAMKII) in HIV patients that exhibit
extreme (high/low) carotid intima-media thickness measurements.
Role: Co-Investigator (09/01/2015 – 08/31/2016)
Training Grant NIH/NINDS T32NS054584 (PI: Cutter)
Research focus is on risk factors for cardiovascular disease in disadvantaged populations
including African Americans.
Role: Post-doc (7/01/07 – 6/30/13)
GenHAT – Genetics of Hypertension Associated Treatments NIH/NHLBI R01 HL063082-05 (PI: Arnett)
To evaluate whether hypertension candidate genotypes can predict therapeutic response to
antihypertensive therapy.
Role: Post-Doc (09/01/99 – 05/31/10)
Internal Pilot Research Funding
Ongoing
Epigenetic biomarkers of preeclampsia risk among mothers with chronic hypertension
UAB Center for Clinical and Translational Sciences Multidisciplinary Network Pilot Program
Conduct genome-wide CpG methylation analysis to identify epigenetic variation contributing
to preeclampsia in mothers with chronic hypertension.
Role: Principal Investigator (4/1/2016 – 3/31/2017)
Completed
Epigenetic risk factors for treatment resistant hypertension in African Americans UAB Minority Health Research Center Pilot and Feasibility Program 2014
Conduct genome-wide CpG methylation analysis to identify epigenetic variation contributing
to treatment resistant hypertension (TRH) in 50 TRH cases and 50 age-matched normotensive
controls using UAB clinic based samples.
Role: Principal Investigator (7/1/2014 – 6/31/2015)
Genes involved in renal Na+/K+ transport modify risk for diabetes on thiazide diuretics UAB Diabetes and Research Training Center Pilot and Feasibility Program 2012
Candidate gene study of risk factors for increased fasting glucose levels due to thiazide diuretic
treatment for hypertension among African Americans participating in the Genetics of
Hypertension Associated Treatment Study.
Role: Principal Investigator (6/1/2012 – 5/31/2013)
*Supported funding NIH/NHLBI 1R01HLHL123782-01 (PI: Irvin)