springercomNEWSonline 1Springer News 72011 Biomedicine

S I Ahmad Nottingham Trent University UK (Ed)

Neurodegenerative DiseasesThe editor of this volume having research interests in the field of ROS production and the damage to cellular systems has identified a number of enzymes showing OH scavenging activities details of which are anticipated to be published in the near future as confirmatory experiments are awaited It is hoped that the information presented in this book on NDs will stimulate both expert and novice researchers in the field with excellent over-views of the current status of research and pointers to future research goals Clinicians nurses as well as families and caregivers should also benefit from the material presented in handling and treating their specialised cases Also the insights gained should be valuable for further understanding of the diseases at molecular levels and should lead to development of new biomarkers novel diagnostic tools and more effective therapeutic drugs to treat the clinical problems raised by these devastating diseases

Features7 Presents overviews of the current status of research and pointers to future research goals Written by experts 7 Covers autism Creutzfeldt-Jakob disease epilepsy frontotemporal lobar degeneration multiple sclerosis Down syndrome premature ageing and spinocerebellar ataxia and many more

Fields of interestNeurosciences Biomedicine general

Target groupsResearch

J Aliberti Cincinnati Childrens Hospital Cincinnati OH USA (Ed)

Control of Innate and Adaptive Immune Responses during Infectious Diseases

Upon infection the host needs to mount vigorous immune response against pathogen in order to successfully control its replication However once the infectious agent is controlled or eliminated host cells need to signal the immune system to slow or cease its activities While vast knowledge has been accumulated through the years on the mechanisms involved in the initiation and effector phases of the immune responses the pathways triggered in order to modulate or end innate and acquired immunity are becoming more evident as evidence for its relevance comes to surface Due to its biological power evidence has surfaced indi-cating that eventually pathogens may take advan-tage of such regulatory pathways in order to escape effector mechanisms and progress to persistence This book will discuss several cellular pathways involved in controlling immune response in the context of infectious diseases their biological consequences and potential ldquohijackrdquo of these path-ways for the benefit of pathogen leading towards pathogen persistence as opposed to clearance

Features7 Explores immune regulatory mechanisms that take place during some of the most relevant infectious diseases worldwide 7 Provides a wide spectrum understanding of the immune system modulates ongoing responses to prevent host pathology 7 Full-color figures illustrate complex ideas

Fields of interestImmunology Microbiology Infectious Diseases

Target groupsProfessionalpractitioner

A Cesario Catholic University of Rome Italy F Marcus European Commission Brussels Belgium (Eds)

Cancer Systems Biology Bioinformatics and MedicineResearch and Clinical Applications

This teaching monograph on systems approaches to cancer research and clinical applications provides a unique synthesis by world-class scien-tists and doctors of laboratory computational and clinical methods thereby establishing the foundations for major advances not possible with current methods Specifically the book 1) Sets the stage by describing the basis of systems biology and bioinformatics approaches and the clinical background of cancer in a systems context 2) Summarizes the laboratory clinical data systems analysis and bioinformatics tools along with infra-structure and resources required 3) Demonstrates the application of these tools to cancer research 4) Extends these tools and methods to clinical diagnosis drug development and treatment appli-cations and 5) Finishes by exploring longer term perspectives and providing conclusions This book reviews the state-of-the-art and goes beyond into new applications

Features7 The worldrsquos top experts describe systems approaches to cancer research and applicationIs uniquely organized to unify all aspects from laboratory to clinic 7 Demonstrates how systems approaches build upon and greatly extend and unify current research practices 7 Demonstrates that cancer systems approaches form a unified field that has already produced major applications 7 A full range of subjects is covered spanning laboratory clinical and medical approaches

Fields of interestCancer Research Systems Biology Oncology

Target groupsResearch

Type of publicationContributed volume

Due September 2011

2011 XXXII 390 p 71 illus (Advances in Experimental Medicine and Biology Volume 724) Hardcover

7 approx euro 15495 | pound139507 approx euro (D) 16580 | euro (A) 17044 | sFr 22200ISBN 978-1-4614-0652-5

9ltHTMERB=eagfcfgt

Type of publicationContributed volume

Due September 2011

2012 140 p 21 illus 20 in color Hardcover

7 approx euro 13995 | pound126507 approx euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-4614-0483-5

9ltHTMERB=eaeidfgt

Type of publicationContributed volume

Due August 2011

2011 X 440 p 40 illus in color Hardcover

7 euro 9995 | pound90007 euro (D) 10695 | euro (A) 10995 | sFr 14350ISBN 978-94-007-1566-0

9ltHTUELA=hbfggagt

springercomNEWSonline2 Springer News 72011Biomedicine

M Chatterjee Jadavpur University Kolkata India K Kashfi City University of New York Medical SchoolNew York NY USA (Eds)

Cell Signaling amp Molecular Targets in Cancer

This book provides an overview of critical compo-nents of cell signaling machinery and its role in epithelial morphogenesis proliferation invasions and angiogenesis in human cancer and discusses novel types of protein kinase pathways

Features7 Identifies various signaling molecules like GRB2 growth factors A1B1 STAT TGFβ 7 Provides a critical assessment of surrogate markers involved in the emergence and progres-sion of cancer 7 Covers the basic principle that drive oncogenesis and pharmacological interven-tions that lead to therapies

ContentsAcknowledgement- GRB2 Signaling as a Molecular Target for Cancer- Human arylamine N-acetyltransferase 1 from drug metabolism to drug target- Targeting Argininosuccinate Synthe-tase in Cancer Therapy- Parathyroid hormon-erelated peptide signaling in cancer- Signaling Molecules as Selective Targets for Therapeutic Strategies in Multiple Myeloma- Role of Bile Acids in Carcinogenesis of Gastrointestinal Tract- AIB1A Transcriptional Coactivator which Integrates Signaling Crosstalk in Cancer Cells- Rational Design of DNA Anti-cancer Agent that Targets Signal Transducer and Activator of Tran-scription 3 (Stat3) for Cancer Therapy- Estrogen Receptor Signaling in Lung Cancer- Microparticle Dissemination of Biological Activities Implica-tions for Cancer Biology- Protein Kinase D Signaling in Cancer- Cell Signaling and Cancer Integrated Fundamental Approach Involving Electron TransferReactive Oxygen Species and Antioxidants- PPARg Thiazolidinediones Lung Cancer- Targeting Signal Transducer and Acti-vator of Transcription (STAT) for Anti-Cancer Therapy- Index

Fields of interestCancer Research PharmacologyToxicology

Target groupsResearch

W C Cho Queen Elizabeth Hospital Hong Kong China (Ed)

Materia Medica for Various Cancers

Cancer is one of the leading killers in the world and the incidence is increasing but most cancer patients and cancer survivors suffer much from the disease and its conventional treatmentsrsquo side effects In the past clinical data showed that some complementary and alternative medicine (CAM) possessed anticancer abilities but some clinicians and scientists have queried about the scientific validity of CAM due to the lack of scientific evidence There is great demand in the knowledge gap to explore the scientific and evidence-based knowledge of CAM in the anticancer field With this aim a book series is needed to structurally deliver the knowledge to readers There have been a number of publications on materia medica for various cancers in recent years the scientific and medical community are thrust for up-to-date information that are supported by concrete labora-tory evidences or clinical trials

Features7 The scientific and medical community are thrust for up-to-date information that are supported by concrete laboratory evidences or clinical trials this book presents the experimental and clinical evidences of anticancer materia medica for various cancers 7 International opinion leaders provide concise reviews and expert opinions on the recent progress of materia medica research in the most common cancers from bench to bedside application 7 An overview of evidence-based materia medica for cancer chemo-prevention and pharmacokinetics is also included

Fields of interestCancer Research Biomedicine general Medicine Public Health general

Target groupsResearch

L J Collins Institute of Fundamental Sciences Massey University Palmerston North New Zealand (Ed)

RNA Infrastructure and Networks

RNAs form complexes with proteins and other RNAs The RNA-infrastructure represents the spatiotemporal interaction of these proteins and RNAs in a cell-wide network RNA Infrastruc-ture and Networks brings together these ideas to illustrate the scope of RNA-based biology and how connecting RNA mechanisms is a powerful tool to investigate regulatory pathways This book is but a taste of the wide range of RNA-based mechanisms that connect in the RNA infrastructure

Features7 Illustrates the scope of RNA-based biology and how connecting 7 RNA mechanisms is a powerful tool to investigate regulatory pathways 7 Presents a wide range of RNA-based mecha-nisms that connect in the RNA infrastructure 7 High quality illustrations

From the contentsThe RNA Infrastructure An Introduction to ncRNA Networks- RNA Interactions- Plant RNA Silencing in Viral Defence- MicroRNAs as Post-Transcriptional Machines and Their Interplay With Cellular Networks- Spatiotemporal Aspects of MicroRNA-Mediated Gene Regulation- Spli-ceosomal RNA Infrastructure The Network of Splicing Components and their Regulation by miRNAs- Construction Structure and Dynamics of Post-Transcriptional Regulatory Network Directed by RNA-Binding Proteins- Safe Keeping the Message mRNP Complexes Tweaking after Transcription- Unexpected functions of tRNA and tRNA Processing Enzymes- Programmed DNA Elimination in Tetrahymena A Small RNA-Mediated Genome Surveillance Mecha-nism- Long Noncoding RNA and Epigenomics- Promoter-Associated Long Noncoding RNAs Repress Transcription Through a RNA Binding Protein TLS

Field of interestNeurosciences

Target groupsResearch

Type of publicationContributed volume

Due November 2011

2012 X 291 p 51 illus 41 in color Hardcover

7 euro 13995 | pound126007 euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-4614-0729-4

9ltHTMERB=eahcjegt

Type of publicationContributed volume

Due September 2011

2011 X 390 p 34 illus in color (Evidence-based Anticancer Complementary and Alternative Medicine Volume 2) Hardcover

7 approx euro 14995 | pound135007 approx euro (D) 16045 | euro (A) 16494 | sFr 21500ISBN 978-94-007-1982-8

9ltHTUELA=hbjicigt

Type of publicationContributed volume

Due August 2011

2011 XXII 274 p 65 illus (Advances in Experimental Medicine and Biology Volume 722) Hardcover

7 approx euro 13995 | pound126507 approx euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-4614-0331-9

9ltHTMERB=eaddbjgt

springercomNEWSonline 3Springer News 72011 Biomedicine

I Couillin CNRS Orleacuteans France V Peacutetrilli Centre Leacuteon Beacuterard Lyon France F Martinon Harvard School of Public Health Boston MA USA (Eds)

The InflammasomesThe inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the matura-tion and biological activities of cytokines such as IL-1 and IL-18 This finding was substantiated by the identification of several mutations in the cias1 gene encoding the human NLRP3 protein responsible for several autoinflammatory disorders such as the Muckle Wells syndrome Since the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response With the contributions of leading international experts in the field this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease

Features7 Overview on the current knowledge of inflammasome biology 7 Highlights the role of inflammasomes in health and disease 7 With contributions by leading international experts

ContentsMolecular definition of inflammasomes- Pyrop-tosis A Caspase-1-dependent programmed cell death and a barrier to infection- Activation of the inflammasome by bacterial pathogens- The Role of Inflammasomes in Viral Infection- Inflamma-some activation in response to eukaryotic patho-gens- Inflammasome activation by pathogenic crystals and particles- Inflammasome activation by danger signals- Toll like receptors and inflam-masomes- Inflammasome in the skin- Cancer inflammasomes and adjuvanticity- Inflammasome and lung pathologies- Mechanisms of NLRP3 inflammasome activation in CAPS patients- Activa-tion and regulation of the NLRP3 inflammasome- Treatment of inflammasome-related disorders

Fields of interestImmunology Infectious Diseases Cell Biology

Target groupsResearch

L A Cowart Medical University of South Carolina Charleston SC USA (Ed)

Sphingolipids and Metabolic Disease

Current thinking holds that obesity derives primarily from overnutrition (though compelling arguments for other mechanisms like endocrine disruption by environmental pollutants also gain support from the literature) In animals over-nutrition is initially handled by adipose tissue expansion however exhaustion of this route of lipid sequestering results in oversupply of lipid to other tissues including skeletal muscle heart liver and others Failure of these tissues to clear excess lipids through either metabolism or sequestra-tion into putatively inert triacylglycerols results in perturbation of bioactive lipid metabolism in cells In particular aberrant generation of bioac-tive sphingolipids is implicated in a multitude of pathological outcomes of metabolic disease including insulin resistance inflammation cardio-myopathy and others This volume addresses not only the fundamentals of sphingolipid metabolism and analysis but also the roles of sphingolipids in these disease processes

Features7 Addresses the fundamentals of sphingo-lipid metabolism and analysis as well as the roles of sphingolipids in these disease processes 7 Features findings that sphingolipids may regulate cholesterol homeostasis through SREBP and lipid efflux 7 Presents broad overviews of tissue-specific effects of sphingolipids while emphasizing interrelatedness of cellular processes and cross-talk between organs

Fields of interestMolecular Medicine Metabolic Diseases

Target groupsResearch

B Deplancke Swiss Federal Institute of Technology Lausanne Switzerland N Gheldof Universiteacute de Lausanne Lausanne Switzerland (Eds)

Gene Regulatory NetworksMethods and Protocols

Gene regulatory networks play a vital role in organismal development and function by controlling gene expression With the availability of complete genome sequences several novel experimental and computational approaches have recently been developed which promise to significantly enhance our ability to comprehen-sively characterize these regulatory networks by enabling the identification of respectively their genomic or regulatory state components or the interactions between these two in unprecedented detail Divided into five convenient sections Gene Regulatory Networks Methods and Protocols details how each of these approaches contributes to a more thorough understanding of the composi-tion and function of gene regulatory networks while providing a comprehensive protocol on how to implement them in the laboratory Written in the highly successful Methods in Molecular Biologytrade series format chapters contain intro-ductions to their respective topics lists of the necessary materials and reagents step-by-step readily reproducible laboratory protocols and notes on troubleshooting and avoiding known pitfalls Authoritative and accessible Gene Regula-tory Networks Methods and Protocols aims to provide novices and experienced researchers alike with a comprehensive and timely toolkit to study gene regulatory networks from the point of data generation to processing visualization and modeling

Features7 Includes cutting-edge methods and proto-cols 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Fields of interestHuman Genetics Gene Expression

Target groupsProfessionalpractitioner

Type of publicationContributed volume

Due July 2011

2011 250 p (Progress in Inflammation Research) Hardcover

7 euro 13995 | pound126007 euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-3-0348-0147-8

9ltHTOAOE=iabehigt

Type of publicationContributed volume

Due August 2011

2011 XVIII 148 p 26 illus (Advances in Experimental Medicine and Biology Volume 721) Hardcover

7 approx euro 13995 | pound126507 approx euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-4614-0649-5

9ltHTMERB=eagejfgt

Type of publicationContributed volume

Due October 2011

2012 415 p 108 illus 14 in color (Methods in Molecular Biology Volume 786) Hardcover

7 approx euro 10495 | pound93007 approx euro (D) 11230 | euro (A) 11545 | sFr 14800ISBN 978-1-61779-291-5

9ltHTMGMH=hjcjbfgt

springercomNEWSonline4 Springer News 72011Biomedicine

M Fuxreiter Hungarian Academy of Sciences Buda-pest Hungary P Tompa Vrije Universiteit Brussel Brussels Belgium (Eds)

FuzzinessStructural Disorder in Protein Complexes

Detailed characterization of fuzzy interactions will be of central importance for understanding the diverse biological functions of intrinsi-cally disordered proteins in complex eukaryotic signaling networks In this volume Peter Tompa and Monika Fuxreiter have assembled a series of papers that address the issue of fuzziness in molecular interactions These papers provide a broad overview of the phenomenon of fuzziness and provide compelling examples of the central role played by fuzzy interactions in regulation of cellular signaling processes and in viral infectivity These contributions summarize the current state of knowledge in this new field and will undoubtedly stimulate future research that will further advance our understanding of fuzziness and its role in biomolecular interactions

Features7 Gives characterization of fuzzy interactions 7 Provides a broad overview of the phenomenon of fuzziness in molecular interactions 7 Summa-rizes the current state of knowledge in this new field

From the contentsFuzzy Complexes A More Stochastic View of Protein Function- Dynamic Fuzziness During Linker Histone Action- Protein Flexibility in Regulation of Cell Proliferation Advantages for Signaling and Opportunities for Novel Therapeu-tics- Interplay Between Protein Order Disorder and Oligomericity in Receptor Signaling- Conse-quences of Fuzziness in the NFkBIkBa Interac-tion- Roles for Intrinsic Disorder and Fuzziness in Generating Context- Specific Function in Ultrabithorax a Hox Transcription Factor- Molecular Recognition by the EWS Transcriptional Activation Domain

Fields of interestBiomedicine general Molecular Medicine

Target groupsResearch

T D Gould Department of Psychiatry University of Maryland School of Medicine Baltimore MD USA (Ed)

Mood and Anxiety Related Phenotypes in MiceCharacterization Using Behavioral Tests Volume II

Preclinical research related to mood and anxiety disorders relies extensively upon mouse behav-ioral tests and models the use of which continues to increase as a greater number of underlying susceptibility genes are discovered new targets for medications are identified and clinical studies reveal novel neurobiological risk factors Mood and Anxiety Related Phenotypes in Mice Char-acterization Using Behavioral Tests Volume II serves as a complement to the previous volume in order to offer a comprehensive resource for the behavioral approaches that are valuable for the characterization of mood and anxiety disorder-related behaviors in mice and the techniques that are utilized in the development of effective medications As a collection presented in the Neuromethods series each chapter provides a brief background and review of the test or model as well as a complete and up-to-date protocol narra-tive Authoritative and comprehensive Mood and Anxiety Related Phenotypes in Mice Character-ization Using Behavioral Tests Volume II is an ideal resource for scientists actively pursuing or interested in establishing vital behavioral protocols in their laboratories

Features7 Presents complete current and up-to-date collection of methods protocols and reviews 7 Contributed by world-renowned scientists with broad experiences in the development and applica-tion of behavioral tasks in miceIncludes clear and concise guides to experimentation

Field of interestNeurosciences

Target groupsProfessionalpractitioner

M Hayat Kean University Union NJ USA (Ed)

Stem Cells and Cancer Stem Cells Volume 2Therapeutic Applications in Disease and Injury

Bearing these points in mind please provide a promotional text of approximately 200 words (up to 1000 characters with spaces) As in volume 1 of this series this volume presents information on stem cells and cancer stem cells Therapeutic Applications in disease and tissueorgan injury Methodologies of regenerative medicine and tissue engineering are major components of this volume Specific stem cells discussed are human embryonic stem cells hematopoietic stem cells cord blood stem cells human pluripotent stem cells gliosarcoma stem cells induced pluripotent stem cells intestinal stem cells human thyroid cancer stem cells tumor stem cells menstrual stem-like cells neural stem cells breast cancer stem cells allogeneic mesenchymal stem cells fetal membrane-derived mesemchynmal stem cells and omental stem cells The method for isolating bone marrow stromal cells is explained Method for generating marmoset-induced pluripotent stem cells using transcription factors is also explained Use of stem cell lines in therapeutic applications is discussed Programming of stem cells is described

Features7 Therapeutic use of stem cells and cancer stem cellsRepair of damaged tissues 7 Cardiomyo-plasty and osteogenic induction 7 Use of stem cells for developing in vitro disease modeling 7 Diagnosis and therapy of diseases

Fields of interestBiomedicine general Occupational MedicineIndustrial Medicine Oncology

Target groupsResearch

Type of publicationContributed volume

Due September 2011

2011 XX 190 p 50 illus 4 in color (Advances in Experimental Medicine and Biology Volume 725) Hardcover

7 approx euro 13995 | pound126507 approx euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-4614-0658-7

9ltHTMERB=eagfihgt

Type of publicationContributed volume

Due September 2011

2011 375 p (Neuromethods Volume 63) Hardcover

7 euro 10995 | pound99007 euro (D) 11765 | euro (A) 12095 | sFr 15800ISBN 978-1-61779-312-7

9ltHTMGMH=hjdbchgt

Type of publicationContributed volume

Due September 2011

2011 XV 485 p 30 illus in color Hardcover

7 approx euro 14995 | pound135007 approx euro (D) 16045 | euro (A) 16494 | sFr 21500ISBN 978-94-007-2015-2

9ltHTUELA=hcabfcgt

springercomNEWSonline 5Springer News 72011 Biomedicine

M Hayat Kean University Union IN USA (Ed)

Tumors of the Central Nervous system Volume 3Brain Tumors (Part 1)

The classification of brain tumors is up-dated using magnetic resonance spectroscopy tech-nology The role of cellular immortality in brain tumors is reviewed Tumor to tumor metastases are a common occurrence for example brain metastasis from breast cancer lung cancer and renal cancer is discussed Genetic profiling and treatment (including neurosurgery) of such brain cancers are explained Breast cancer patients treated with certain drugs (eg capecitabine and lapatinib can develop CNS tumors Role of brain tumor suppressor genes (eg NRPB gene) is pointed out Biomarkers used to diagnose brain malignancies are explained in detail A number of imaging modalities used for diagnosing and assessing the effectiveness of treatments of brain tumors are presented The imaging methods discussed include MRI PET CT MRSi and SPECT Also is discussed the impact of PET using radiolabeled amino acids on brain tumors

Features7 Frozen section evaluation of CNS lesions 7 Methods of electrochemotherapy for primary and secondary brain tumors 7 Stereotactic radiosurgery for brain metastasis and ultrasound surgery 7 Epilepsy in brain tumor patients and treatment 7 Pain management following crani-otomy and quality of life of patients with brain tumors

Fields of interestCancer Research Neuroradiology Neurosurgery

Target groupsResearch

M Hayat Kean University Union NJ USA (Ed)

Tumors of the Central Nervous System Volume 5Astrocytomas Hemangioblastomas and Gangliogliomas

Brain tumors Astrocytomas Hemangioblas-tomas and Gangliogliomas are discussed in detail especially their diagnosis therapy and prognosis Role of methylation in promoting malignancy is pointed out Role of proteins such as antiapop-totic protein and Dopple protein is emphasized Role of receptors in cancer is also included Nervous system germ cell tumors are discussed The mechanism of cell migration of astrocytomas is detailed Use of various imaging techniques in diagnosing brain tumors is explained Gene expression profiling in subependymal giant cell astrocytoma is included Other techniques such as time-resolved laser-induced fluorescence spectroscopy are discussed Nanotechnology-based therapy is included A detailed discussion of the immunohistochemical factors affecting surgery is given Treatment of pilomyxoid astrocytoma with chemotherapy is explained Also are discussed the survival and recurrence of astrocytomas This volume will be useful to brain cancer researchers and physicians Radiosurgery for hemangioblas-toma patients is explained

Features7 Diagnosis of brain tumors including imaging techniques 7 Therapy for brain tumors and its effectiveness 7 Biomarkers for brain tumors 7 Molecular genetics of brain tumors 7 Genetics of epilepsy

Fields of interestCancer Research Neuroradiology Neurosurgery

Target groupsResearch

T L Jackson University of Michigan Ann Arbor MI USA (Ed)

Mathematical and Computational Modeling of Tumor VasculaturePutting Angiogenesis in 4-Dimensions

To profoundly understand biology and harness its intricacies for human benefit and the mitiga-tion of human harm requires cross-disciplinary approaches that incorporate sophisticated compu-tational and mathematical modeling techniques These integrative strategies are essential to achieve rapid and significant progress in issues in health and disease which span molecular cellular and tissue levels The use of mathematical models to describe various aspects of tumor growth has a very long history dating back over six decades Recently however experimental and computa-tional advances have improved our in the under-standing of how processes act at multiple scales to mediate the development of tumor vasculature and drive the advancement of cancer This book will showcase the development and utilization of new computational and mathematical approaches to address multiscale challenges associated with tumor vascular development

Features7 Provides a variety of interesting and innovative mathematical modeling approaches 7 Discusses the development and effects of tumor vasculature using mathematical models 7 Illustrates the innovation and new trend of mathematical models in cancer research

Fields of interestCancer Research PharmacologyToxicology

Target groupsResearch

Type of publicationContributed volume

Available

2011 XXII 382 p 75 illus 53 in color Hardcover

7 euro 14995 | pound135007 euro (D) 16045 | euro (A) 16494 | sFr 21500ISBN 978-94-007-1398-7

9ltHTUELA=hbdjihgt

Type of publicationContributed volume

Due September 2011

2011 XV 485 p 32 illus 22 in color Hardcover

7 approx euro 14995 | pound135007 approx euro (D) 16045 | euro (A) 16494 | sFr 21500ISBN 978-94-007-2018-3

9ltHTUELA=hcabidgt

Type of publicationContributed volume

Due September 2011

2011 X 305 p 137 illus 80 in color Hardcover

7 approx euro 13995 | pound126507 approx euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-4614-0051-6

9ltHTMERB=eaafbggt

springercomNEWSonline6 Springer News 72011Biomedicine

JIMD Reports

Series editor Society for the Study of Inborn Errors of Metabolism

JIMD Reports publishes case and short research reports in the area of inherited metabolic disor-ders Case reports highlight some unusual or previ-ously unrecorded feature relevant to the disorder or serve as an important reminder of clinical or biochemical features of a Mendelian disorder

Society for the Study of Inborn Errors of Metabolism SSIEM London UK (Ed)

JIMD Reports - Case and Research Reports 20111

JIMD Reports publishes case and short research reports in the area of inherited metabolic disor-ders Case reports highlight some unusual or previ-ously unrecorded feature relevant to the disorder or serve as an important reminder of clinical or biochemical features of a Mendelian disorder

Features7 Unique collection of case and research reports on rare metabolic disorders 7 Contains unusual or previously unrecorded features relevant to metabolic disorders 7 All contributions rigor-ously peer-reviewed

ContentsDifferent case reports

Fields of interestHuman Genetics Metabolic Diseases Pediatrics

Target groupsResearch

A E Kalyuzhny R amp D Systems Inc Minneapolis MN USA (Ed)

Handbook of ELISPOTMethods and Protocols

Enzyme-linked immunospot assay (ELISPOT) has been known for some time as a unique state-of-the-art technique for studying the cytokine-secreting activity of immune system cells and it appears to be one of the fast growing applications in biomedical research becoming an indispens-able tool in vaccine development HIV research transplantation studies and cancer and allergy research The second edition of Handbook of ELISPOT Methods and Protocols only the second book in the field which is entirely dedicated to ELISPOT assay shares the detailed techniques that have been developed since the release of the popular first ed Straight from the labs of seasoned experts this book covers setting and performing ELISPOT assays ELISPOT for veterinary research advanced ELISPOT techniques image and data analysis as well as vaccine development and diag-nostics Written in the highly successful Methods in Molecular Biologytrade series format chapters include introductions to their respective chapters lists of the necessary materials and reagents step-by-step readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls Authoritative and cutting-edge Handbook of ELISPOT Methods and Protocols Second Edition serves as a compilation of a technical refer-ence and a troubleshooting guide for researchers both experienced and novice worldwide in order to advance the usage of this key tool

Features7 Extends and expands upon the hands-on methodologies of the popular first edition 7 Features expert techniques ready for the labora-tory 7 Includes key tips and implementation advice to ensure successful results

Fields of interestImmunology Laboratory Medicine

Target groupsProfessionalpractitioner

New Series

Type of publicationContributed volume

Due September 2011

2011 X 100 p (JIMD Reports Volume 1) Softcover

7 euro 9995 | pound90007 euro (D) 10695 | euro (A) 10995 | sFr 14350ISBN 978-3-642-17707-1

9ltHTOGPC=bhhahbgt

Type of publicationContributed volume

Due October 2011

2nd ed 2011 255 p 60 illus 13 in color (Methods in Molecular Biology Volume 792) Hardcover

7 approx euro 8995 | pound79507 approx euro (D) 9625 | euro (A) 9895 | sFr 12650ISBN 978-1-61779-324-0

9ltHTMGMH=hjdceagt

springercomNEWSonline 7Springer News 72011 Biomedicine

P Kosma University of Natural Resources and Life Sciences Vienna Austria S Muumlller-Loennies Forschungszentrum Borstel Germany (Eds)

Anticarbohydrate AntibodiesFrom Molecular Basis to Clinical Application

Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies The success of several licensed carbohydrate based vaccines against bacte-rial pathogens such as Haemophilus influenzae type b Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential However the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design In addition to therapy antibodies in general serve as diagnostic tools in medical and scientific laboratories In this setting high affinity and exquisite specificity are important factors for their successful use ldquoAnticarbohydrate Antibodies ndash from molecular basis to clinical applicationrdquo compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications

Features7 Anticarbohydrate antibodies from the basics to clinical application are described 7 Describes state of the art technologies 7 Written from the leading researchers in the field

Fields of interestAntibodies Immunology

Target groupsResearch

A Kuchment Scientific American New York NY USA

The Forgotten CureThe Past and Future of Phage Therapies

This book fills a void Never before has a comprehensive history of phage therapymdasha once-neglected now resurgent fieldmdashbeen written Kuchment writes from the perspective of the eager student of history for the common reader

Features7 Comprehensive unprecedented history of phage therapy 7 Offers a lay persons perspective on an often ignored topic of research Has a broad appeal beyond just researchersscientists

ContentsPrologue- Helpful Little Bodies- Inside Stalinrsquos Empire- The Fading of Phage Therapy- Naked Genes- Theyrsquore Not a Panacea- In Poland Phages for Diabetes- The Renaissance of Phage Therapy- The Startups- Four Companies Four Strate-gies- Cows and Chickens- Approval At Last- In Treatment- Epilogue- Index

Fields of interestMedical Microbiology Laboratory Medicine Immunology

Target groupsPopulargeneral

B Kuumlster (Ed)

Kinase InhibitorsMethods and Protocols

Protein and lipid kinases are often the master regulators of cell signaling in eukaryotic systems The human genome codes for more than 500 of these enzymes and their misregulation has been shown to be involved in the onset and progression of many diseases including cancer and inflamma-tion Therefore small molecule kinase inhibitors have become important research tools for the elucidation of the many biological roles of kinases and their mechanisms of action Kinase inhibi-tors thus also contribute significantly to the drug pipelines of the pharmaceutical and biotechnology industries and to the growing need to treat cancer and inflammation In Kinase Inhibitors Methods and Protocols experts in kinase biology drug discovery and clinical research present a series of exemplary methods that can be used to address the many challenges facing scientists in the discovery and development of kinase inhibitors both for research and clinical use Written in the highly successful Methods in Molecular Biologytrade series format chapters contain introductions to their respective topics lists of the necessary materials and reagents step-by-step readily reproducible laboratory protocols and notes on troubleshooting and avoiding known pitfalls

Features7 Includes cutting-edge methods and proto-cols 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Fields of interestMolecular Medicine Cell Biology

Target groupsProfessionalpractitioner

Type of publicationContributed volume

Due November 2011

2012 500 p 150 illus 100 in color Hardcover

7 approx euro 14995 | pound135007 approx euro (D) 16045 | euro (A) 16494 | sFr 21500ISBN 978-3-7091-0869-7

9ltHTOHLJ=baigjhgt

Type of publicationPopular science

Due October 2011

2011 XVII 150 p Softcover

7 approx euro 1495 | pound13997 approx euro (D) 1600 | euro (A) 1645 | sFr 2150ISBN 978-1-4614-0250-3

9ltHTMERB=eacfadgt

Type of publicationContributed volume

Due October 2011

2011 275 p 50 illus 11 in color (Methods in Molecular Biology Volume 795) Hardcover

7 euro 9495 | pound85507 euro (D) 10160 | euro (A) 10445 | sFr 13650ISBN 978-1-61779-336-3

9ltHTMGMH=hjddgdgt

springercomNEWSonline8 Springer News 72011Biomedicine

E L Lane Welsh School of Pharmacy Cardiff University Cardiff UK S B Dunnett The Brain Repair Group School of Biosciences Cardiff University Cardiff UK (Eds)

Animal Models of Movement DisordersVolume I

Movement is the way that animals interact with their environment and is under the organization and complex control of the brain and spinal cord Multiple central nervous systems including cortex basal ganglia cerebellum and brainstem interact to provide precise motor control and integration Damage or disease within these systems cause profound motor disturbances in man which can be effectively modeled in animals to develop a better understanding and treatment of the human condition Animal Models of Movement Disorders introduces a variety of methods and techniques used to model and assess motor function in experimental animals from lower orders such as drosophila and c elegans through verte-brate species including fish to mammals such as rodents and non-human primates The most advanced contemporary models in each system are presented at multiple levels of analysis from molecular and genetic modeling lesions anatomy neurochemistry to imaging and behavior

Features7 Serves as a comprehensive and valuable reference for those studying motor disorders 7 Provides appropriate models and assessment tools 7 Includes clear easy to follow methods with expert implementation advice

Fields of interestNeurosciences Neurology Animal Models

Target groupsProfessionalpractitioner

E L Lane Welsh School of Pharmacy Cardiff University Cardiff UK S B Dunnett The Brain Repair Group School of Biosciences Cardiff University Cardiff UK (Eds)

Animal Models of Movement DisordersVolume II

Volume II of this detailed collection contains sections on the basal ganglia neo- and allo-cortical systems cerebellar and brain stem systems as well as spinal cord systems Comprehensive and meticulous Animal Models of Movement Disorders serves as a valuable reference for those studying motor disorders by covering method-ologies in detail and providing the information necessary to consider both the appropriate models and assessment tools that can most informatively answer the key experimental issues in the field

Features7 Serves as a comprehensive and valuable reference for those studying motor disorders 7 Provides appropriate models and assessment tools 7 Includes clear easy to follow methods with expert implementation advice

From the contentsBehavioral Assessment of Genetic Mouse Models of Huntingtonrsquos Disease- Excitotoxic Lesions of the Rodent Striatum- Combination Lesion Models of MSA- The Role of the Dorsal Striatum in Instrumental Conditioning- 3-Nitropropionic Acid and Other Metabolic Toxin Lesions of the Striatum- Functional Assessment of Subcortical Ischemia- Functional Organization of Rat and Mouse Motor Cortex- Forebrain Circuits Control-ling Whisker Movements

Fields of interestNeurosciences Neurology Animal Models

Target groupsProfessionalpractitioner

T Lawrence CNRS-INSERM-Universiteacute de la Meacutediterraneacutee Parc Scientifique de Luminy Marseille France T Hagemann Queen Mary University of London Barts and the London School of Medicine and Dentistry London UK (Eds)

Tumour-Associated Macrophages

The subject of Tumour-Associated Macrophages is of interest in the cancer research community and this book promises to be among the first to discuss a definitive theory on the role of macrophage in tumor development

Features7 Among the first books to collectively discuss a definitive theory on the role of macrophage in tumor development 7 The book appeals to basic scientist working in immunology tumor biology and to some extent pharmacology and biochemistry clinicians involved in preclinical tumor biology research 7 Research and intensive discussion of Ik-B and NF-kB

ContentsPreface- Macrophage Phenotype in Tumors- Role of Tumour-Associated Macrophages in the Regula-tion of Tumour Angiogenesis- The Role of Tumor-Associated Macrophages in Malignant Invasion- Tumor-Induced Immune Suppression by Myeloid Cells- TAM A Moving Clinical Target- Arginine Metanolism and Tumour Associated Macro-phages- Indoleamine 23-dioxygenaseAmino acid metabolism and tumor-associated macrophages regulation in cancer-associated inflammation and immune escape- Vascular Endothelial Growth Factor and Tumor-associated macrophages- TLR Signaling and Tumor-associated Macro-phages- SHIP and Tumor-Associated Macro-phages- NF-KappaB-Mediated Regulation of Tumor-Associated Macrophages Mechanisms and Signifance- Role of hypoxia-inducible transcrip-tion factors HIF-a for TAM function- Index

Fields of interestCancer Research PharmacologyToxicology

Target groupsResearch

Type of publicationContributed volume

Due October 2011

2011 425 p 74 illus 35 in color (Neuromethods Volume 61) Hardcover

7 approx euro 10495 | pound93007 approx euro (D) 11230 | euro (A) 11545 | sFr 14800ISBN 978-1-61779-297-7

9ltHTMGMH=hjcjhhgt

Type of publicationContributed volume

Due October 2011

2011 445 p 77 illus 29 in color (Neuromethods Volume 62) Hardcover

7 approx euro 10495 | pound93007 approx euro (D) 11230 | euro (A) 11545 | sFr 14800ISBN 978-1-61779-300-4

9ltHTMGMH=hjdaaegt

Type of publicationContributed volume

Due November 2011

2011 X 145 p 15 illus 10 in color Hardcover

7 euro 13995 | pound126007 euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-4614-0661-7

9ltHTMERB=eaggbhgt

springercomNEWSonline 9Springer News 72011 Biomedicine

D LeRoith Mount Sinai School of Medicine New York NY USA (Ed)

Insulin-like Growth Factors and CancerFrom Basic Biology to Therapeutics

The book will detail the history successes and failures of targeted therapies for cancer with a particular focus on IGF systems and cancer

Features7 Comprehensive look at the history of targeted therapies in cancer 7 Edited by a recognized expert in IGF Systems and cancer 7 Discusses the successes and failures of targeted therapies and cancer

ContentsPreface- Epidemiology of IGF-1 and Cancer- Aging and Cancer The IGF-I Connection- Obesity Type 2 Diabetes and Cancer- IGF System and Breast Cancer- The Role of Insulin-Like Growth Factor Signaling in Prostate Cancer Development and Progression- Mouse Models of IGF-1 Deficiency- Insulin-like Growth Factor Signaling in Pediatric Sarcomas- Cancer Genes Tumor Suppressors and Regulation of IGF-1R Expression in Cancer- Mouse Models of IGF-1R and Cancer- Targeting the Insulin-Like Growth Factor-I Receptor in Cancer Therapy- Targeting Insulin-like Growth Factor (IGF-1R) and Insulin Receptor Signaling by Tyrosine Kinase Inhibi-tors in Cancer- Calories and Cancer The Role of Insulin-like Growth Factor- Cancer Cell Metabo-lism- Overlaps between the Insulin and IGF-1R and Cancer- Index

Fields of interestCancer Research PharmacologyToxicology

Target groupsResearch

G Manfredi H Kawamata Fujita Weill Medical College of Cornell University New York NY USA (Eds)

NeurodegenerationMethods and Protocols

Neurodegenerative disorders such as Alzheimerrsquos and Parkinsonrsquos disease are a growing burden on our society Understanding and treating these common diseases is one of the major current challenges for the biomedical field In Neurode-generation Methods and Protocols experts in the field tackle this challenge and present cutting-edge analytical and technological approaches to study the mechanisms underlying neurodegenerative processes Organizes into five sections chapters detail protocols for isolating and culturing cells from the nervous system production and use of animal models characterization of cell death analytical tools to study disease mechanisms and therapeutic approaches for neurodegeneration Written in the successful Methods in Molecular Biologytrade series format chapters include introduc-tions to their respective topics lists of the neces-sary materials and reagents step-by-step readily reproducible protocols and notes on trouble-shooting and avoiding known pitfallsAuthoritative and easily accessible Neurodegeneration Methods and Protocols serves as an ideal guide to both novice and professional researchers in the field of neurodegeneration

Features7 Includes cutting-edge methods and proto-cols 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Field of interestNeurosciences

Target groupsProfessionalpractitioner

A Merighi Dipartimento di Morfofisiologia Veterinaria Universitagrave degli Studi di Torino Grugliasco Torino Italy (Ed)

NeuropeptidesMethods and Protocols

Since the early days the field of neuropeptide biology has dramatically widened and today the ultimate frontiers in neuropeptide research lie in the development of pharmacologically active compounds that are capable of crossing the blood-brain barrier to exert their biological role(s) in vivo and in the construction of genetic vectors to be employed in gene therapy Neuro-peptides Methods and Protocols presents a readily reproducible collection of established and emerging techniques for neuropeptide research as contributed by expert researchers in the field The detailed methods presented cover subjects such as immunocytochemical localization biochemical characterization functional analysis develop-ment and production of genetic probes and the design of neuropeptide derivatives for cellular neurobiology as well as the potential therapeutic applications

Features7 Features contributions from scientists with direct experience in one or more of the fields of neuropeptide research 7 Includes detailed protocols relevant to a wide range of scientists 7 Provides key tips and expert implementation advice to ensure successful results

Fields of interestNeurosciences Neurochemistry

Target groupsProfessionalpractitioner

Type of publicationContributed volume

Due October 2011

2012 VII 191 p 20 illus 17 in color (Cancer Drug Discovery and Development) Hardcover

7 approx euro 13995 | pound126507 approx euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-4614-0597-9

9ltHTMERB=eafjhjgt

Type of publicationContributed volume

Due October 2011

2011 475 p 102 illus 9 in color (Methods in Molecular Biology Volume 793) Hardcover

7 approx euro 10495 | pound93007 approx euro (D) 11230 | euro (A) 11545 | sFr 14800ISBN 978-1-61779-327-1

9ltHTMGMH=hjdchbgt

Type of publicationContributed volume

Due October 2011

2011 350 p 56 illus 12 in color With online filesupdate (Methods in Molecular Biology Volume 789) Hardcover

7 approx euro 10495 | pound93007 approx euro (D) 11230 | euro (A) 11545 | sFr 14800ISBN 978-1-61779-309-7

9ltHTMGMH=hjdajhgt

springercomNEWSonline10 Springer News 72011Biomedicine

L ODriscoll School of Pharmacy amp Pharmaceutical Sciences and MTCI Trinity College Dublin Dublin Ireland (Ed)

Gene Expression ProfilingMethods and Protocols

Understanding gene expression and how it changes under normal and pathological conditions is essential to our understanding of the fundamentals of cell biology through to the targeted treatment of disease In Gene Expression Profiling Methods and Protocols Second Edition experts in their particular fields compile detailed protocols for a broad range of techniques currently available and being further developed for the analysis of gene expression at the DNA RNA and protein levels Written in the highly successful Methods in Molecular Biologytrade series format chapters include introductions to their respective topics lists of the necessary materials and reagents step-by-step readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls Practical and easy-to-use Gene Expression Profiling Methods and Protocols Second Edition presents a collection of clearly described and illus-trated chapters certain to be helpful to researchers in academia in hospitals and in industry who are interested in applying techniques whether basic or advanced for the analysis of gene expression

Features7 Presents a broad range of available and devel-oping techniques for the analysis of gene expres-sion at the DNA RNA and protein levels 7 Features easy to follow step-by-step procedures ready for the labIncludes vital tips and expert implementation advice

Fields of interestHuman Genetics Gene Expression

Target groupsProfessionalpractitioner

T M Penning University of Pennsylvania Philadelphia PA USA (Ed)

Chemical Carcinogenesis

This volume will provide a contemporary account of advances in chemical carcinogenesis It will promote the view that it is chemical alteration of the DNA that is a route cause of many cancers The multi-stage model of chemical carcinogenesis exposure to major classes of human carcinogens and their mode-of-action will be a focal point The balance between metabolic activation to form biological reactive intermediates and their detoxi-fication ensuing DNA-lesions and their repair will be profiled It will describe the chemical changes that occur in DNA that result from endogenous insults including epigenetic changes that lead to gene silencing It will describe major mechanisms of mutagenesis affects on tumor suppressor genes and proto-oncogenes and how cell-cycle check points can be by-passed by the ldquostealth-likerdquo properties of chemical carcinogens Environ-mental agents that can promote tumor formation will be discussed The monograph will have wide appeal as a knowledge base for graduate students post-doctoral fellows and faculty interested in this aspect of cancer causation and research

Features7 Focuses of this volume chemical carcino-genesis exposure to major classes of human carcinogens and their mode-of-action the balance between metabolic activation to form biological reactive intermediates and their detoxification and environmental agents that can promote tumor formationappeals to graduate students post-doctoral fellows and faculty interested in this aspect of cancer causation and research

Fields of interestCancer Research PharmacologyToxicology

Target groupsResearch

A J Pollard University of Oxford Oxford United Kingdom A Finn University of Bristol Bristol United Kingdom N Curtis Royal Childrens Hospital Melbourne Parkville Australia (Eds)

Hot Topics in Infection and Immunity in Children VIII

Book covers course with topics in infectious diseases in children and is intended for Pediatric Infectious disease clinical researchers trainees trainers and all those who manage the research of children with infections and the children themselves The conference is being supported by several societies and is sponsored by several pharmaceutical companies such as Aventis Baxter Chiron Vaccines Wyeth etc ToC reflects the scientific program found here httpwwwoxfordiicorgcourse

Features7 Includes information on a wide range of diseases affecting children all over the world 7 Features a diverse and learned group of contributors 7 Covers prevention treatment and general theory

From the contentsOur time of pestilence purchasing immunity and ignoring the misery of others- Neonatal meningitis can we do better- Approaches towards avoiding lifelong antiretrovial therapy in paediatric HIV infection- How short is long enough for treatment of bone and joint infec-tion- Whatrsquos new in diagnostic testing and treatment approaches for Mycoplasma pneu-moniae infections in children- Pigs poultry and pandemic influenza how zoonotic pathogens threaten human health- Kingella kingae infections in children an update- Influenza pandemics- Management of shunt related infections- Nontu-berculous lymphadenopathy in children using the evidence to plan optimal management- Pediatric brucellosis an (almost) forgotten disease- Q fever still more queries than answers- Rickettsioses in children a clinical approach

Fields of interestImmunology Infectious Diseases Pharmacy

Target groupsResearch

Type of publicationContributed volume

Due October 2011

2nd ed 2011 200 p 37 illus 26 in color (Methods in Molecular Biology Volume 784) Hardcover

7 approx euro 8995 | pound79507 approx euro (D) 9625 | euro (A) 9895 | sFr 12650ISBN 978-1-61779-288-5

9ltHTMGMH=hjciifgt

Type of publicationContributed volume

Available

2011 XV 440 p 160 illus 64 in color With 2 16 page color inserts (Current Cancer Research) Hardcover

7 euro 13995 | pound126007 euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-61737-994-9

9ltHTMGMH=dhjjejgt

Type of publicationContributed volume

Due July 2011

2011 200 p 25 illus (Advances in Experimental Medicine and Biology Tentative volume 719) Hardcover

7 approx euro 13995 | pound126507 approx euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-4614-0203-9

9ltHTMERB=eacadjgt

springercomNEWSonline 11Springer News 72011 Biomedicine

R J Roselli Vanderbilt University Nashville TX USA K R Diller The University of Texas Austin TX USA

Biotransport Principles and Applications

Introduction to Biotransport Principles is a concise text covering the fundamentals of biotransport including biological applications of fluid heat and mass transport

Features7 This text is unique because no textbooks in biomedical engineering or engineering currently combine taxonomic content with a suite of open-ended challenge-based problems that can be used to probe all aspects of the subject in the classroom

ContentsPart I Fundamentals of How People Learn (HPL)- Introduction to HPL Methodology- Part II Fundamental Concepts in Biotransport- Funda-mental Concepts in Biotransport- Modeling and Solving Biotransport Problems- Part III Biofluid Transport- Rheology of Biological Fluids- Macro-scopic Approach for Biofluid Transport- Shell Balance Approach for One Dimensional Biofluid Transport- General Microscopic Approach for Biofluid Transport- Part IV Bioheat Transport- Heat Transfer Fundamentals- Macroscopic Approach to Bioheat Transport- Shell Balance Approach for 1-D Bioheat Transport- General Microscopic Approach for Bioheat Transport- Section V Biological Mass Transport- Mass Transfer Fundamentals- Macroscopic Approach to Biomass Transport- Shell Balance Approach for 1-D Biomass Transport- General Microscopic Approach for Biomass Transport

Fields of interestBiomedicine general Biophysics and Biological Physics Biomedical Engineering

Target groupsUpper undergraduate

V Saha University of Manchester Manchester UK P Kearns School of Cancer Sciences University of Birmingham Edgbaston Birmingham B15 2TT (Eds)

New Agents for the Treatment of Acute Lymphoblastic Leukemia

The majority of cancers present at a relatively advanced stage in which invasion within the primary organ is well established and metastases to lymph and distant organs are either clinically apparent or present at the microscopic level However it is increasingly recognized that the natural history of cancer formation is a long and complex path taking many years to develop to a clinically apparent stage in most cases Further-more for most solid tumours there is a pre-inva-sive or intraepithelial stage of disease This affords the opportunity for early detection and prevention of invasive disease and hence a cure However with this advancing knowledge comes a whole plethora of questions which will be explored in this monograph

Features7 Examines the strategies for the use of new agents as well as possible targets of therapy in this disease 7 Discusses and proposes some solu-tions to these issues acute lymphoblastic leukemia 7 Will be useful to all levels of professionals students and researchers

ContentsThe need for new agents- Identifying pre-clinical agents- Pre-clinical evaluation- Design of early phase trials- Strategies for trial design and analyses- Overview on Molecular and Animal models of ALL- Apoptosis BCL2- Targeting Stem Cells- Nucleoside Analogues- Flt3 Inhibi-tors- Tyrosine Kinase Inhibitors- Monoclonal Antibodies- Proteasome inhibitors- Targeting epigenetic pathways in ALL- Incorporating new therapies in frontline protocols-

Fields of interestCancer Research PharmacologyToxicology

Target groupsResearch

M Terabe J A Berzofsky Vaccine Branch National Cancer Institute NIH Bethesda MD USA (Eds)

Natural Killer T cellsBalancing the Regulation of Tumor Immunity

This book will cover primary roles of NKT cells in immunity to cancer in both mouse tumor models and cancer patients There are several chapters describing general aspects of NKT cells

Features7 Natural killer T (NKT) cells discussed in this book are CD1d-restricted T cells 7 Overview of structures and functions of glycolipid antigens 7 Explains roles of NKT cells in human lymphoma patients

ContentsPreface- Introduction Mechanisms of NKT cell-mediated adjuvant activity and function of iPS-derived NKT cells- Structure and Recognition of Antigens for Invariant NKT Cells- Invariant NKT cell-based vaccine strategies- Immune regulation of tumor immunity by NKT cells- The Regulation of CD1d+ and CD1d- tumors by NKT Cells- DC-based immunotherapy targeting NKT cells- Therapeutic Approaches Utilising NKT Cells- NKT Cells of Cancer Patients amp How Models can Inform Therapeutic Plans- Understanding the role of Natural Killer T (NKT) cells in hematologic malignancies progress and challenges- Clinical trials with α-galactosylceramide (KRN7000) in advanced cancer- Clinical trials of invariant Natural Killer T cell-based immunotherapy for cancer- Index

Fields of interestCancer Research PharmacologyToxicology

Target groupsResearch

Type of publicationUndergraduate textbook

Available

2011 XXVII 650 p 200 illus 100 in color Hardcover

7 euro 7995 | pound72007 euro (D) 8555 | euro (A) 8795 | sFr 11500ISBN 978-1-4419-8118-9

9ltHTMEPB=jibbijgt

Type of publicationContributed volume

Available

2011 XVIII 338 p 24 illus 12 in color With 1 4-page color insert Hardcover

7 euro 13995 | pound126007 euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-4419-8458-6

9ltHTMEPB=jiefiggt

Type of publicationProfessional book

Due October 2011

2012 VII 169 p 24 illus 16 in color (Cancer Drug Discovery and Development) Hardcover

7 approx euro 13995 | pound126507 approx euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-4614-0612-9

9ltHTMERB=eagbcjgt

springercomNEWSonline12 Springer News 72011Biomedicine

T O Tollefsbol University of Alabama Birmingham AL USA (Ed)

Epigenetics Protocols

The field of epigenetics has played a major role at the forefront not only of molecular biology but also of medical genetics and clinical medi-cine Few disciplines have experienced growth comparable to that which we have witnessed for epigenetics in the past decade The goal of Epigenetics Protocols Second Edition is to high-light select techniques that have been mainstays in the field as well as to cover methods that are espe-cially relevant to extant discoveries in epigenetics This volume focuses on the two broad areas of epigenetics DNA methylation and chromatin modifications and also covers the complex topic of computational methods for epigenetic analyses which is essential to a complete understanding of the vast body of information that is being derived with the use of these newly-developed tools Written in the highly successful Methods in Molecular Biologytrade series format chapters contain introductions to their respective topics lists of the necessary materials and reagents step-by-step readily reproducible laboratory protocols and notes on troubleshooting and avoiding known pitfalls Authoritative and accessible Epigenetics Protocols Second Edition serves as an ideal guide to advanced students basic scientists and clinical researchers as well as clinicians and biotechnology investigators who wish to continue exploring this exciting and progressive research field

Features7 Includes cutting-edge methods and proto-cols 7 Provides step-by-step detail essential for reproducible results 7 Contains key notes and implementation advice from the experts

Fields of interestHuman Genetics Gene Expression

Target groupsProfessionalpractitioner

O Troshichev Arctiv and Antarctic Research Institute St Petersburg Russia A Janzhura Arctic and Antarctic Research Institute St Petersburg Russia

Space Weather Monitoring by Groundbased MeansPC Index

This book demonstrates that the method based on the ground polar cap magnetic observations is a reliable diagnosis of the solar wind energy coming into the magnetosphere Method for the uninter-ruptive monitoring of the magnetosphere state (ie space weather) It shows that the solar wind energy pumping power can be described by the PC growth rate thus the magnetospheric substorms features are predetermined by the PC dynamics Furthermore it goes on to show that the beginning and ending of magnetic storms is predictable The magnetic storm start only if the solar energy input into the magnetosphere exceeds a certain level and stops when the energy input turns out to be below this level

Features7 Demonstrates that ground polar cap magnetic observations provide reliable diagnosis of solar wind energy 7 Shows that the development of magnetospheric substorms can be monitored 7 Allows the characaterization of dynamics in solar wind energy input

From the contentsPreface- 1 Physical backgrounds and origin of the idea- 2 Concept of the PC index 3 Unified procedure for on-line calculation of the 1-min PCN and PCS indices- 4 Validation of the unified procedure- 5 Differences in summer and winter PC indices and their physical reasons- 6 Response of PC index to sudden pulses in the solar wind dynamic pressure- 7 PC index as an indicator of the substorm development- 8 PC index as an indicator of the magnetic storm development

Fields of interestBiomedicine general MeteorologyClimatology Environmental Physics

Target groupsResearch

N Vergnolle INSERM Toulouse France M Chignard Institut Pasteur Paris France (Eds)

Proteases and Their Receptors in Inflammation

Proteases are everywhere from prokaryotes to eukaryotes from virus to bacteria and in all human tissues playing a role in many biological functions Among these functions the inflamma-tory reaction is of particular interest In inflamed tissues proteases can have a microbial andor host origin and are involved not only in tissue remod-eling but also in specific signaling to resident or inflammatory cells thereby contributing to the innate immune responseThis volume presents all advances in our knowledge of the role proteases and their inhibitors play in various diseases associated with inflammatory response Mecha-nisms involved in protease signaling to cells are presented and the different types of proteases that are present at inflammatory sites and their effects on the course of inflammation are discussed Finally the evidence for considering proteases and their receptors as potential molecular targets for therapeutic interventions in the treatment of inflammatory diseases is discussed in the context of specific organ inflammatory pathologies (the lung gastrointestinal tract skin joints etc)

Features7 Presents the most advanced knowledge in the field 7 Written by renowned experts 7 Richly illustrated

From the contentsProteolytic enzymes and cell signaling Pharma-cological Lessons- Serine and cysteine proteases and their inhibitors as antimicrobial agents and immune modulators- Kallikreins protease involve-ment in skin pathologies supports a new view of the origin of inflamed itchy skin- Proteases from Inflammatory Cells regulation of inflammatory response- Matrix Metalloproteinases inhibitors as new anti-inflammatory drugs- Dual role for prote-ases in lung Inflammation Proteases and Fibrosis

Fields of interestImmunology Cell Biology Infectious Diseases

Target groupsResearch

Type of publicationContributed volume

Due October 2011

2nd ed 2011 330 p 54 illus 9 in color (Methods in Molecular Biology Volume 791) Hardcover

7 approx euro 10495 | pound93007 approx euro (D) 11230 | euro (A) 11545 | sFr 14800ISBN 978-1-61779-315-8

9ltHTMGMH=hjdbfigt

Type of publicationMonograph

Due November 2011

2012 X 400 p 85 illus 10 in color (Springer Praxis Books Environmental Sciences) Hardcover

7 approx euro 12995 | pound117007 approx euro (D) 13905 | euro (A) 14294 | sFr 18650ISBN 978-3-642-16802-4

9ltHTOGPC=bgiacegt

Type of publicationContributed volume

Due August 2011

2011 300 p (Progress in Inflammation Research) Hardcover

7 approx euro 13995 | pound126007 approx euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-3-0348-0156-0

9ltHTOAOE=iabfgagt

springercomNEWSonline 13Springer News 72011 Biomedicine

J C Wright DURECT Corporation Cupertino CA USA D J Burgess School of Pharmacy University of Connecticut Storrs CT USA (Eds)

Long Acting Injections and Implants

Long acting injections and implants improve therapy enhance patient compliance improve dosing convenience and are the most appro-priate formulation choice for drugs that undergo extensive first pass metabolism or that exhibit poor oral bioavailability An intriguing variety of technologies have been developed to provide long acting injections and implants Many consider-ations need to go into the design of these systems in order to translate a concept from the lab bench to actual therapy for a patient This book surveys and summarizes the field Topics covered in Long Acting Injections and Implants include the historical development of the field drugs diseases and clinical applications for long acting injections and implants anatomy and physiology for these systems specific injectable technologies (including lipophilic solutions aqueous suspensions microspheres liposomes in situ forming depots and self-assembling lipid formulations) specific implantable technologies (including osmotic implants drug eluting stents and microfabricated systems) peptide protein and vaccine delivery sterilization drug release testing and regulatory aspects of long acting injections and implants

Features7 Provides a comprehensive overview of the scientific and regulatory challenges 7 Gives description of the types of systems major areas of current application and research together with current commercial applications 7 The reader is introduced to the host response to biomaterialsforeign body and the influence of environmental conditions on the design and development of long acting injections and implants

Fields of interestBiomedicine general Pharmaceutical SciencesTechnology

Target groupsResearch

J Xie (Ed)

Hedgehog signaling activation in human cancer and its clinical implications

Understanding the role of hedgehog signaling in cancer is critically important for novel cancer therapeutics The hedgehog pathway is a major pathway regulating cell differentiation tissue polarity stem cell maintenance and cell prolifera-tion It is known by now that activation of this pathway occurs in a variety of human cancer including basal cell carcinomas (BCCs) medullo-blastomas leukemia gastrointestinal lung ovarian breast and prostate cancers This book provides insightful views suitable for graduate students medical students undergraduate students basic and clinical scientists cancer patients as well as the general public

Features7 Presents up-to-date information in this exciting research area 7 Summarizes major advances made on hedgehog signaling mechanisms activa-tion of the pathway in various human cancer types 7 Highlights current challenges in our efforts to translate the basic biology into clinic 7 Provides insightful views suitable for graduate undergrad-uate and medical students basic and clinical scien-tists cancer patients as well as the general public

ContentsOverview of hedgehog signaling pathway- Regu-lation of Hh morphogene gradient- Smooth-ened Signaling through a G-protein Effector Network- Kinases and phosphatases in hedgehog signaling- Signaling Cross-talk of Oncogenic KRAS and Hedgehog Pathways in Pancreatic Cancer- Crosstalks between PKC and hedgehog signaling- Activation of Hh signaling in human cancer- Hedgehog signaling in pediatric brain tumors- Hedgehog Signaling in Mammary Gland Development and Breast Cancer- Hedgehog signaling and cancer therapeutic resis-tance- Small-molecule Inhibitors of the Hedgehog Pathway- Cyclopamine and its derivatives for cancer therapeutics

Fields of interestCancer Research PharmacologyToxicology

Target groupsResearch

T Yao Duke University Durham NC USA E Seto Moffitt Cancer Center Tampa FL USA (Eds)

Histone Deacetylases the Biology and Clinical Implication

The book highlights work from many different labs that taught us abnormal HDACs potentially contribute to the development or progression of many human diseases including immune dysfunc-tions heart disease cancer memory impairment aging and metabolic disorders

Features7 Will certainly serve as a reference to catalyze new collaborations between experts within the HDAC field 7 Written by leading authorities in the field 7 With numerous illustrations

Fields of interestPharmacologyToxicology Biomedicine general Posttranslational Modification

Target groupsResearch

Type of publicationContributed volume

Due October 2011

2011 XIII 492 p 146 illus 39 in color (Advances in Delivery Science and Technology) Hardcover

7 approx euro 17995 | pound159507 approx euro (D) 19255 | euro (A) 19794 | sFr 25400ISBN 978-1-4614-0553-5

9ltHTMERB=eaffdfgt

Type of publicationContributed volume

Available

2011 IX 217 p 24 illus 10 in color Hardcover

7 euro 13995 | pound126007 euro (D) 14975 | euro (A) 15394 | sFr 20100ISBN 978-1-4419-8434-0

9ltHTMEPB=jiedeagt

Type of publicationHandbook

Due September 2011

2011 350 p 31 illus 20 in color (Handbook of Experimental Pharmacology Volume 206) Hardcover

7 euro 30900 | pound278507 euro (D) 33063 | euro (A) 33990 | sFr 44300ISBN 978-3-642-21630-5

9ltHTOGPC=cbgdafgt