safe prescribing: the physician’s ... - internal medicine...ppioids for chronic back pain. aim....
TRANSCRIPT
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SAFE PRESCRIBING:THE PHYSICIAN’S CHALLENGE
Elizabeth S. Grace, MD, FAAFP
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SAFE PRESCRIBING:THE PHYSICIAN’S CHALLENGE
Elizabeth S. Grace, M.D., FAAFP
Medical DirectorCPEP, Center for Personalized Education for Physicians
Assistant Clinical ProfessorDepartment of Family MedicineUniversity of Colorado School of Medicine
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DISCLOSURES
Dr. Grace has no conflicts of interest to disclose.
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OBJECTIVES
• Assess the risk of opioid abuse in patients to whom you are considering or already prescribing opioids
• Establish monitoring strategies that are commensurate with risk assessment
• Learn the role of SBIRT in addressing the spectrum of substance use
• Define and identify substance use disorder
• Identify the drug-seeking patient
• Learn ways to locate local addiction treatment resources
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A national problem
17,000 deaths from painkiller ODs annually
More deaths from Rx Drug OD than MVAs
A Colorado problem
300 deaths in CO each year from Painkiller ODs
CO 12th in self-reported nonmedical use of opioid
Annual deaths from painkillers more than tripled from 2000 to 2013
PRESCRIPTION DRUG ABUSE
http://takemedsseriously.org/
Photo: cc lic Frankie Leon
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To adequately address patients’ acute and chronic pain…
…while following safe prescribing principles.
THE PHYSICIAN’S CHALLENGE
Photo: CC lic Wendy
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BUT I DON’T TREAT CHRONIC PAIN!
Every chronic pain patient was first an acute pain patient
The transformation is not always clear
Every pill that your patients don’t use can be diverted
Colorado teens: Rx drugs “easier to get than beer”
Street value of oxycodone: about $1 per mg
Prescriptions for acute sports injuries may put adolescents at risk for misuse
http://takemedsseriously.org/
Veliz, Philip, Quyen M. Epstein-Ngo, Elizabeth Meier, Paula Lynn Ross-Durow, Sean Esteban Mccabe, and Carol J. Boyd. "Painfully
Obvious: A Longitudinal Examination of Medical Use and Misuse of Opioid Medication Among Adolescent Sports
Participants." Journal of Adolescent Health 54.3 (2014): 333-40. Web.
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THE PATIENT EVALUATION:CHRONIC PAINFUL CONDITIONSThorough evaluation (S/O) of:
1) The painful condition – including function
2) Risk – including SUD
Formulate an Assessment
1) The painful condition
2) Risk
Formulate a Plan
1) The painful condition
2) Risk
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PATIENT EVALUATIONSubjective
Objective
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S/O: THE PAINFUL CONDITIONSubjective:
CC/HP, including prior work-up and treatment
Reported level of function and functional limitations
Objective:
Examination
Imaging
Electrodiagnostics, other testing
Observed level of function and functional limitations
Review of old records for verification
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S/O: RISKSubjective:
• Personal and family substance use history (include history of overdose)
→ SBIRT if positive
• Psychiatric history
• History of trauma/abuse
• Also consider: Comorbidities and medications that ↑ risk of respiratory depression (COPD, OSA; benzos, other opioids, etc.
Objective:
• Urine drug testing & PDMP review - before you prescribe
• Consider screening for anxiety and depression
• ?Nocturnal oximetry? If at risk
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PATIENT EVALUATION Assessment
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A: THE PAINFUL CONDITION
What is the pain generator? What is the diagnosis?
What type of pain is it?
• Nociceptive: somatic (DJD); visceral (IBS, endometriosis)
• Neuropathic: e.g., diabetic neuropathy, PHN, radiculopathy
• Mixed: migraine
• Opioid-related: hyperalgesia, tolerance (Pain: Assessment, Non-
Opioid Treatment Approaches and Opioid Management. ICSI Guideline).
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A: RISK
Risk for abuse/addiction
Comorbidities
Concurrent medications
• Use a tool to help you quantify the risk of opioid abuse
http://www.opioidrisk.com/book/export/html/613
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ASSESSING RISK - TOOLS
High sensitivity and specificity for those at risk (Webster and Webster 2005)
Quick and easy to score – 5 items
Low Risk 0-3Moderate Risk 4-7High Risk 8+
High score: increased likelihood of future abusive drug-related behavior
https://www.drugabuse.gov/sites/default/files/files/OpioidRiskTool.pdf
http://www.opioidrisk.com/book/export/html/613
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ASSESSING RISK: TOOLS
http://nationalpaincentre.mcmaster.ca/documents/soapp_r_sample_watermark.pdf
http://www.opioidrisk.com/book/export/html/613
Validated (Butler 2008)
24 questions, 5 min est
Harder to deceive, but less sens/spec than original version
Easy to Score
Positive: ≥ 18
High score: increased likelihood of drug abuse
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RECOGNIZING SUBSTANCE USE DISORDER
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DIAGNOSING SUBSTANCE USE DISORDERDSM 5 DIAGNOSTIC CRITERIA
DSM IV: abuse, dependence
DSM 5: substance use disorder with three severities
11 criteria: severity based on number of positive criteria
2-3 Mild
4-5 Moderate
6 or more Severe
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DIAGNOSING SUBSTANCE USE DISORDERDSM 5 DIAGNOSTIC CRITERIA1. Taking the substance in larger amounts and for longer than intended
2. Wanting to cut down or quit but not being able to do it
3. Spending a lot of time obtaining the substance
4. Craving or a strong desire to use
5. Repeatedly unable to carry out major obligations at work, school, or home due to use
http://www.buppractice.com/node/12351
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DIAGNOSING SUBSTANCE USE DISORDERDSM 5 DIAGNOSTIC CRITERIA6. Continued use despite persistent or recurring social or interpersonal problems caused or made worse by use
7. Stopping or reducing important social, occupational, or recreational activities due to use
8. Recurrent use in physically hazardous situations
9. Consistent use despite acknowledgment of persistent or recurrent physical or psychological difficulties from using
http://www.buppractice.com/node/12351
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DIAGNOSING SUBSTANCE USE DISORDERDSM 5 DIAGNOSTIC CRITERIA
10. Tolerance as defined by either a need for markedly increased amounts to achieve intoxication or desired effect or markedly diminished effect with continued use of the same amount. (Does not apply when used appropriately under medical supervision)
11. Withdrawal manifesting as either characteristic syndrome or the substance is used to avoid withdrawal (Does not apply when used appropriately under medical supervision)
http://www.buppractice.com/node/12351
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RECOGNIZING THE DRUG SEEKING PATIENTRecognize “red flags”
Demand to be seen right away, often at the end of the day
New to town, passing through, doctor unavailable
Call after hours
Unusual and assertive behavior
At extremes of being over- or under-dressed
Lack of impulse control, mood instability, emotionally labile
Overly complementary (“You are the only one who understands…”)
https://www.deadiversion.usdoj.gov/pubs/brochures/drugabuser.htm
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RECOGNIZING THE DRUG SEEKING PATIENT
Recognize “red flags” (continued)
“Textbook” history, or evasive and vague
Demonstrates unusual degree of knowledge of drugs
Lack of interest in a diagnosis
Asks for specific drugs
Track marks and scars
https://www.deadiversion.usdoj.gov/pubs/brochures/drugabuser.htm
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THE DRUG SEEKING PATIENT
Differential diagnosis:
Diversion: a legal matter
Addiction: a disorder that needs treatment
Pseudoaddiction: a response to inadequate pain control
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PATIENT EVALUATION Plan
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P: TREATING THE CONDITION/PAIN
Evidence-based treatments for the condition and type of pain being treated
Therapy of underlying disorder (e.g., diabetes)
Establish treatment goals:
• Patient specific functional treatment goals
• Realistic goals for pain reduction (not realistic to expect elimination of pain)
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P: TREATING THE CONDITION/PAIN (CONTINUED)
Psychologic/psychotherapy: CBT
Complementary and integrative: acupuncture, yoga
Physical/rehabilitation modalities: massage therapy, manipulation therapy, trigger point injection, PRP injection
Interventional treatment: Facet blocks, ESI, others
Referrals
PharmacologicPain: Assessment, Non-Opioid Treatment Approaches and Opioid Management. N.p., n.d. Web. 13 Dec. 2016.
<https://www.icsi.org/guidelines__more/catalog_guidelines_and_more/catalog_guidelines/catalog_neurological_guidelines/pain/>.
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P: TREATING THE CONDITION/PAIN (CONTINUED)
Pharmacologic Therapy
Non-opioid medications
Acetaminophen, NSAIDs/COX-2 inhibitors, steroids, muscle relaxants, calcium channel modulators and other anti-seizure medications, antidepressants (TCAs, SNRIs)
Topical medications
Opioid medications
Only when indicated, other treatments inadequate
Informed consent
Start with low dose IR formulations, not ER/LA preparation
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P: TREATING THE CONDITION/PAIN (CONTINUED)
Pharmacologic treatment targeting the pathophysiology
Nociceptive
Topical agents
Acetaminophen, NSAIDs/COX-2, steroids, muscle relaxants, antidepressants
Neuropathic
Antidepressants (TCAs and SNRIs) and calcium channel modulators
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P: MONITORING AND MITIGATING RISKMonitoring for harms of non-opioid medications (e.g.
acetaminophen, NSAIDs, others)
Renal and liver function, GI bleeding, sedation
Monitoring for harms of opioid medications
Controlled substance agreement
Plan consistent with the level of risk
Establish plan for and frequency of patient monitoring
(see next slide)
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P: MONITORING AND MITIGATING RISK• Urine drug testing – when starting and AT LEAST annually (CDC)
• Review of PDMP – when starting and AT LEAST every 3 months (CDC)
• Carefully assess/reassess if doses reach 50, 90, 120 MED/MME
• Avoid prescribing opioids and benzodiazepines concurrently (CDC) (FDA warning)
• Periodic reevaluation
5 A’s: Analgesia, Activity, Adverse events, Affect, Aberrancy (Based on Passik & Weinreb, 1998)
• Periodic reassessment with risk tools (COMM)
• Referrals, as indicated (psych, addiction, pain management)
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ADDICTIONSBIRT
Motivational interviewing
Referral to addition treatment resources
https://findtreatment.samhsa.gov
http://www.samhsa.gov/medication-assisted-treatment/physician-program-data/treatment-physician-locator
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ABERRANCY MANAGEMENTAberrancy: Deviation from controlled substance agreement
Investigate the reason
Inadvertent: Loss Theft Memory problems
Medical: Self-directed pain management
Non-medical: Diversion Personal non-medical use
Seen in 5-80% of pain population on opioids 1-3
Response to aberrancy: depends on severity1 Martell. Ppioids for chronic back pain. AIM. 2007;146(2):116-272 Fishbain. % chronic nonmalignant pain patients on opioids develop addiction, aberrancy. Pain Med. 2008;9(4):444-593 Fleming. Reported aberrancies of substance misuse in 1º care. Pain Med. 2008;9(8):1098-106
Steven Wright, MD. Basics of Chronic Pain Management. CPEP
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OPIOID-RELATED ABERRANCIESLOW LEVEL• Early refill once
• Self-directed dose ↑ once
• Missed / late for appointment
• Low dose alcohol for special occasion only
• Not informing prescriber of mild adverse reactions
• Non-notification of other opioid prescriber for good reason x1
• Occasional problem-solving phone calls rather than office visits
• Non-participation in non-medication pain approaches for economic reasons
Steve Wright, MD. Basics of Pain Management for the Non-Pain
Management Specialist. CPEP.
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OPIOID-RELATED ABERRANCIESINTERMEDIATE LEVEL
• Early refill >1
• Consider self addicted
• Lost / stolen prescription
• Unauthorized overuse >1
• Focused on specific opioid
• Unauthorized cannabis use
• Limited interest in non-opioid approaches
• Multiple phone calls rather than office visits
• Not informing prescriber of significant adverse reactions
• Non-opioid substance addiction slip → return to abstinence
• Non-participation in non-medication approaches for noneconomic reasons
Steve Wright, MD. Basics of Pain Management for the Non-Pain Management Specialist. CPEP.
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OPIOID-RELATED ABERRANCIESHIGH LEVEL
• Forged prescription
• Cocaine / Stimulant use
• Involvement in DUI / MVA
• > 3 lower level aberrancies
• Non-pain related opioid use
• IV or IN route of administration
• Aggressive demands for opioids
• Active non-opioid substance relapse
• Refusal of non-medication approaches for pain
• Intoxication / Oversedation: reported or observed
• Multi-sourcing: other prescribers / street / internet
• Stealing opioids / Obtaining from nonmedical sources
• Reliance on problem-solving phone calls rather than office visits
Steve Wright, MD. Basics of Pain Management for the Non-Pain Management Specialist. CPEP.
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PATIENT EVALUATION Documentation
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DOCUMENTATIONhttp://static.practicalpainmanagement.com/sites/default/files/image
cache/inline-image-wide/images/2014/02/07/t1.jpg
Also … PDMP findings
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PATIENT EVALUATION Resources
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TOOL BOX• Screening tool for substance use/abuse: NIDA, CAGE-AID, AUDIT, DAST, NIDA
Modified Assist
• Screening tool for opioid risk – initial: ORT, DIRE, SOAPP-R
• Screening tool for ongoing monitoring of opioid risk and misuse: COMM, ABC
• Screening tool for depression and anxiety: HAM-D, PHQ 9, GAD 7, PHQ 4
• Pain assessment tool: Numeric Intensity Rating Scale, Brief Pain Inventory
• Function assessment tool: Brief Pain Inventory, Rolland Morris Disability Questionnaire
• Controlled substance Agreement: NIDA, AAPM
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ADDITIONAL RESOURCESGeneral
• FSMB Model Policy on the Use of Opioid Analgesics in the Treatment of Chronic Painhttp://www.fsmb.org/Media/Default/PDF/FSMB/Advocacy/pain_policy_july2013.pdf
• DEA Practitioner’s Manual (2006 last pub)https://www.deadiversion.usdoj.gov/pubs/manuals/pract/pract_manual012508.pdf
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ADDITIONAL RESOURCESGeneral
• CDC Checklist for Prescribing Opioids for Chronic Painhttps://www.cdc.gov/drugoverdose/pdf/PDO_Checklist-a.pdf
• Washington State Agency Medical Directors’ Group Interagency Guideline on Prescribing Opioids for Pain, 3rd Edition, June 2015http://www.agencymeddirectors.wa.gov/Files/2015AMDGOpioidGuideline.pdf
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ADDITIONAL RESOURCESMotivational Interviewing
• Center for Substance Abuse Treatment. Enhancing Motivation for Change in Substance Abuse Treatment. Treatment Improvement Protocol (TIP) Series, No. 35. HHS Publication No. (SMA) 13-4212. Rockville, MD: Substance Abuse and Mental Health Services Administration, 1999.
• Motivational Interviewing for Healthcare Professionals - Online Educationhttp://www.ucdenver.edu/academics/colleges/nursing/programs-admissions/CE-PD/Pages/Motivational-Interviewing-for-Healthcare-Professionals.aspx
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ADDITIONAL RESOURCESSBIRT
• FACT SHEET Substance (Other Than Tobacco) Abuse Structured Assessment and Brief Intervention (SBIRT) Serviceshttp://www.integration.samhsa.gov/sbirt/SBIRT_Factsheet_ICN904084.pdf
• SBIRT: Screening, Brief Intervention, and Referral to Treatmenthttp://www.integration.samhsa.gov/clinical-practice/sbirt
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ADDITIONAL RESOURCESTapering
• CDC Pocket Guide: Tapering Opioids for Chronic Painhttps://www.cdc.gov/drugoverdose/pdf/clinical_pocket_guide_tapering-a.pdfDEA Practitioner’s Manual (2006 last pub)
• Tapering Long-term Opioid Therapy in Chronic Noncancer Painhttp://www.mayoclinicproceedings.org/article/S0025-6196(15)00303-1/fulltext
• Helping Patients Taper from Benzodiazepineshttp://www.va.gov/PAINMANAGEMENT/docs/OSI_6_Toolkit_Taper_Benzodiazepines_Clinicians.pdf
• Benzodiazepines: How They Work and How To Withdraw (Ashton Manual)http://www.benzo.org.uk/manual/
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ADDITIONAL RESOURCESUrine Drug Testing
• Washington State Agency Medical Directors’ Group Interagency Guideline on Prescribing Opioids for Pain, 3rd
Edition, June 2015. Appendix D http://www.agencymeddirectors.wa.gov/Files/2015AMDGOpioidGuideline.pdf
• Urine Drug Testinghttp://www.opioidrisk.com/print/book/export/html/487
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PRACTICE RESOURCES
"Policy for Prescribing and Dispensing Opioids.pdf." Google Docs. DORA, n.d. Web. 12 Dec. 2016. https://drive.google.com/file/d/0B-
K5DhxXxJZbd01vVXdTTklZLVU/view?pref=2&pli=1
Centers for Disease Control and Prevention. Centers for Disease Control and Prevention, 18 Mar. 2016. Web. 12 Dec. 2016.
<http://www.cdc.gov/mmwr/volumes/65/rr/rr6501e1.htm>
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PRACTICE RESOURCES
CDC 1
Caution with any opioid dose
For acute pain: Only 3-7 days of opioids
For chronic pain:
Reevaluate 1-4 weeks after initiation, dose escalation
>50 MED Reassess risk / benefit
>90 MED Avoid or carefully justify
Colorado Department of Regulatory Agencies 2
Use lowest effective opioid dose
>120 MED Add safeguards, consult specialist
>90 days Reevaluate opioid use
TD, ER/LA Use clinical judgment
1 CDC Opioid Prescribing Guideline for Chronic Pain. 2016. Accessed 4/12/162 Colorado Opioid Prescribing, Dispensing Quad-Regulator Policy. 2014. Accessed 12/7/16
Basics of Chronic Pain Management. CPEP
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PRACTICE RESOURCES
https://www.colorado.gov/pacific/dora/PDMP
The Washington State Agency Medical Director’s Group (AMDG)
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PATIENT EVALUATION Summary
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SAFE PRESCRIBING:THE PHYSICIAN’S CHALLENGE
Thorough evaluation of pain, function, and risk initially and on an ongoing basis
Use objective tools to assess risk and use in treatment planning
Know the guidelines and document your clinical rationale carefully, especially if practicing outside the guidelines
Do not practice beyond your scope of practice/capabilities: refer to Pain Management, Addiction, Psychology, and Psychiatry
Learn MI skills
Become familiar with treatment resources in your area
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BEWARE OF COMMON PITFALLS
• Failure to recognize misuse, addiction, or the drug seeking patient
• Failure to identify individuals at higher risk
• Discomfort declining patient requests and demands
• Not sure how to manage aberrant behavior or how to help the addicted patient
• Failure to document clinical rationale
• Failure to refer when over our heads