safety of the rare sugar d-psicose · foods 06 research theme safety of the rare sugar d-psicose...

Foods 06 ●Research theme Safety of the rare sugar D-psicose (Keywords: D-Psicose, Safety) ●Research representative Tatsuhiro Matsuo, Professor, Kagawa University Faculty of Agriculture The safety of D-psicose must be confirmed before it can be used as a food material. In the Intelligent Cluster Formation Project, its safety testing was entrusted to Mitsubishi Chemical Safety Institute, Ltd. Five items were tested, and (1) good decomposability on the “ simplified decomposition test” , (2) no mutagenicity on the “mutagenicity test using microorganisms”, (3) acute toxicity of D-psicose being higher than an LD50 of 2,000 mg/kg on the “single dose oral toxicity test using rats”, (4) very mild irritativity against the eye on the “primary eye irritation test using rabbits”, and (5) no irritativity to the skin on the “primary skin irritation test using rabbits” have been reported. Also, on the acute toxicity test (rats), the LD50 of D-psicose was 16.3 g/kg, which is classified as average in toxicity categories and is similar to that of sucralose already used as a food additive (used as a sweetener in diet coke). On chronic toxicity tests (6－18 months, rats), no marked difference was noted in the results of general hematology or serum chemistry tests compared with the control group, and the values were in the normal ranges. Furthermore, when the D-psicose contents of various foods were measured to evaluate the routine D-psicose intake level, its contents were particularly high in sweets and seasonings, indicating that we are regularly taking D-psicose from various food materials (Figure). ●The safety of D-psicose, mass production of which has become possible, is being established. (1) Foods in general (4) Sweeteners (2) Food additives (5) Foods and beverages (3) Foods for specified health uses (6) Cosmetics References:Matsuo, T. et al.: Effects of oral acute administration and subchronic feeding of several levels of D-psicose in rats. J. Nutr. Sci. Vitaminol., 48, 512-516 (2002). Oshima, H. et al.: Psicose contents in various food products and its origin. Food Sci. Technol. Res., 12, 137- 143 (2006). (Developer’ s comment) D-Psicose was shown experimentally (in rats and humans) to suppress increases in the blood sugar level, and inhibition of digestive enzyme activities and promotion of glycogen synthesis have been suggested as mechanisms of this effect. Therefore, D-psicose may be useful as a functional food. (Developer’ s contact address) TEL: +81-87-891-3082 E-mail: [email protected] Glyco-Bio Project Team, Technical Promotion Division, Kagawa Industry Support Foundation 1st floor, FROM Kagawa, 2217-16 Hayashi-cho, Takamatsu City, Kagawa 761-0301 Japan TEL: +81-87-840-0338 FAX: +81-87-864-6303 URL http://www.kagawa-isf.jp/ Kagawa Prefecture Glyco-Biocluster Formation Project Collection of Technological Achievements Related to Rare Sugars Outline of technology Sales points Expected application fields and products Comparison with existing products References, patents, etc. Other matters to note Figure: Daily D-psicose intake from various foods Advantages D-Psicose Low Suppressed High A few thousand yen/kg Calorie Safety Responses of blood sugar level Cost Sucrose High Marked Very high 200 yen/kg Disadvantages

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Foods 06

●Research theme

Safety of the rare sugar D-psicose(Keywords: D-Psicose, Safety)

●Research representative Tatsuhiro Matsuo, Professor, Kagawa University Faculty of Agriculture

The safety of D-psicose must be confirmedbefore it can be used as a food material.In the Intelligent Cluster Formation Project, itssafety testing was entrusted to MitsubishiChemical Safety Institute, Ltd. Five items weretested, and (1) good decomposability on the“ simplified decomposition test” , (2) nomutagenicity on the “mutagenicity test usingmicroorganisms”, (3) acute toxicity of D-psicosebeing higher than an LD50 of 2,000 mg/kg on the“single dose oral toxicity test using rats”, (4)very mild irritativity against the eye on the“primary eye irritation test using rabbits”, and (5) no irritativity to the skin on the “primary skin irritation testusing rabbits” have been reported. Also, on the acute toxicity test (rats), the LD50 of D-psicose was 16.3 g/kg, which is classified as average in toxicitycategories and is similar to that of sucralose already used as a food additive (used as a sweetener in diet coke). Onchronic toxicity tests (6－18 months, rats), no marked difference was noted in the results of general hematology orserum chemistry tests compared with the control group, and the values were in the normal ranges.Furthermore, when the D-psicose contents of various foods were measured to evaluate the routine D-psicose intakelevel, its contents were particularly high in sweets and seasonings, indicating that we are regularly taking D-psicosefrom various food materials (Figure).

●The safety of D-psicose, mass production of which has become possible, is being established.

(1) Foods in general (4) Sweeteners(2) Food additives (5) Foods and beverages(3) Foods for specified health uses (6) Cosmetics

References:Matsuo, T. et al.: Effects of oral acute administration and subchronic feeding of several levels of D-psicosein rats. J. Nutr. Sci. Vitaminol., 48, 512-516 (2002).Oshima, H. et al.: Psicose contents in various food products and its origin. Food Sci. Technol. Res., 12, 137-143 (2006).

(Developer’s comment)D-Psicose was shown experimentally (in rats and humans) to suppress increases in the blood sugar level, andinhibition of digestive enzyme activities and promotion of glycogen synthesis have been suggested as mechanisms ofthis effect. Therefore, D-psicose may be useful as a functional food. (Developer’s contact address)TEL: +81-87-891-3082 E-mail: [email protected]

Glyco-Bio Project Team

, Technical Promotion D

ivision, Kagawa Industry Support Foundation 1st floor, FR

OM Kagaw

a, 2217-16 Hayashi-cho, Takam

atsu City, Kagaw

a761-0301 Japan

TEL: +81-87-840-0338 FAX: +81-87-864-6303 URL http://w

ww.kagaw

a-isf.jp/

Kagaw

a Prefecture G