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PY 202
B.Pharmacy 11 Semester
Examination, December 20 1 4
Pharmaceutics-II (Physical Pharmacy)
Time : Three Hours
Maximum Marks : 70
Note: i) Answer five questions. In each question part A, B. C compulsory and D part has
internal choice.
ii) All parts of each question are to be attempted at one place.
iii) All questions carry equal marks. out of which part A and B (Max.50 words) carry 2
marks, part C
(Max 100 words) carry 3 marks, part D Max.400 words carry 7 marks.
iv) Except numericals, Derivation. Design and Drawing etc.
1. a) Define the term micromeritics.
b) Write the particle dimensions in pharmaceutical disperse systems.
c) Write Edmundson equation for determination of average particle size.
d) Explain the methods for determining surface area of particles.
OR
Write the derived properties of powder.
2. a) Define the terms: solubility, saturated solution.
b) What is phase rule?
c) What are ideal and real solutions?
d) Explain the effect of temperature on solubility of salts.
OR
What is the minimum pH required for the complete solubility of the drug in a stock solution
containing 6g of Phenobarbital sodium in 100 ml of a 30% by volume alcoholic solution?
(Molecular weight of Phenobarbital sodium is 254, So of Phenobarbital is 0.028. pKa is 7.92
at 25°C).
3 a) Define the term interfacial tension.
b) What is spreading coefficient?
c) Write a note on HLB.
d) What are surfactants? Write the applications of surface active agents.
OR
A sample of chloroform rose to a height of 3.67 cm at 25°C in a capillary tube having an
inside radius of
0.01cm. What is the surface tension of chloroform at this temperature? (Density of
chloroform is
1.476 g/cm3; g=981 m/s2)
4 a) What is Fiek's First law of diffusion?
b) WriteNo, es and Whitney equation.
c) State Hixson-Crowell cube Root Law.
d) Explain types of Dissolution Test Apparatus USP.
OR
Write a note on diffusion principles in biologic systems.
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5. a) Define the terms: rheology, viscosity.
b) What are Newtonian systems?
c) Define plastic flow, pseudoplastic flow, dilatant flow.
d) Explain the principle and working of cup and bot: viscometer.
OR
Write the applications of rheology in pharmacy.
6. a) Define the term complexes.
b) What are inclusion compounds?
c) What do you mean by self association?
d) Classify complexes with suitable examples.
OR
Explain the factors affecting complexation and proteir binding.
7. a) Define the terms: buffer, pH.
b) What are pH indicators?
c) How buffer capacity is calculated?
d) Explain the methods of adjusting tonicity and pH.
OR
Find out the concentration of sodium chloride required to make 1% of boric acid isotonic
with blood plasma. (Freezing point depression of 1% boric acid is-O.288°C; Freezing point
depression of 1% solution of sodium chloride is -0.576°C).
8. a) Define the term colloids.
b) Classify colloids.
c) Explain the principle of micellization.
d) Explain the optical and electrical properties of colloids.
OR
Write the pharmaceutical applications of colloids.
9. a) Define the terms: multiple emulsions, micro emulsions.
b) Classify semisolid dosage forms.
c) Explain the theory of sedimentation.
d) Write a note on physical stability of emulsions.
OR
Write a note on rheologic properties of semisolids.
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PY - 203
B.Pharmacy II Semester Examination, December 20 14
Pharmaceutical Chemistry-III (Organic-I)
Time : Three Hours Maximum Marks : 70
Note: i) Answer five questions. In each question part A, B, C is compulsory and D part has
internal choice.
ii) All parts of each question are to be attempted at one place.
iii) All questions carry equal marks, out ofwhich partA and B (Max.50 words) carry 2 marks,
part C (Max. 00 words) carry 3 marks, part D (Max.400 words) carry 7 marks.
iv) Except numericals, Derivation, Design and Drawing etc.
1. a) What are Electrophiles?
b) Define Diastereomers.
c) What is chirality? Describe the RIS configuration of chiral carbon.
d) What is racemic modification? How the resolution of racemic mixture is done?
OR
Describe the SP' hybridization of methane.
2. a) Describe the free radical substitution reaction ofAlkanc
b) Describe the structure of Carbonium ion
c) Describe the structure of Benzene.
d)Describe the Benzene mechanism
OR
Discuss the mechanism for Electrophilic aromatic substitution in Benzene.
3. a) Write the reaction of Sodium Acetylides with Alkyl Halides.
b) Describe the Resonance in conjugated dienes.
c) Describe the conformations of Cycloalkanes.
d) Describe the SN2 substitution reaction.
OR
Describe the E2 Elimination reaction.
4 a) Write the physical properties of Ethers.
b) Discuss the physical properties of Alcohols.
c) Compare the acidity of phenols with alcohols.
d) Describe the chemical reactivity of Phenols.
OR
Discuss the chemical reactions of Alcohols.
5. a) Describe the structure of carbonyl group.
b) Discuss the physical properties of aldehyde and ketone.
c) Describe the nomenclature of amino compounds.
d) Describe the nucleophilic addition reaction to > C = 0 group.
OR
Describe the chemical reaction of carboxylic acids.
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PY - 204
B.Pharmacy II Semester
Examination, December 2014
Pharmacognosy -I
Time : Three Hours
Maximum Marks : 70
Note: i) Answer five questions. In each question part At B. C is compulsory and D part has
internal choice.
ii) All parts of each questions are to be attempted at one place.
iii) All questions carry equal marks, out of which part A and B (Max.50 words) carry 2
marks, part C (Ma100 words) carry 3 marks, part D (Max.400 words) carry 7 marks.
iv) Except numerical, Derivation, Design and Drawing etc.
1. a) Write the name of any two plants of labiates family with their uses.
b) Rauwolfia and vinca belongs to which family.
c) Write a note on Leguminosae with example of medicinally important plants.
d) Describe salient feature of the family papaveraceae. What is opium?
OR
Describe the diagnostic characters of Rubiaceae family. Name any three medicinal plants of
Liliaceae family.
2. a) Pharmacognosy is derived from two Greek words…….. &………
b) Give the name of alternative system of medicine.
c) Describe advantage and disadvantage of chemical classification of crude drugs.
d) Write definition, history and scope of pharmacognosy.
OR
Discuss taxonomic and therapeutic system of classification of crude drugs.
3. a) Explain agricultural pest controlling method.
b) Flow humidity affect cultivation of plants?
c) Advantages of drugs obtained from cultivated plants.
d) Discuss various natural pest controlling agents..
OR
Describe in brief the factors influencing cultivation of medicinal plants.
4. a) Write synonym of Isabgol seed.
b) Give active constituents of Agar.
c) Give classification of drug containing carbohydrates.
d) What do you mean by quality control of drugs? Describe microscopic methods of
evaluation of drugs.
OR
What are Lipids? .Classify them and discuss general chemistry of lipids.
5. a) Oleo-gum-resin are mixture of……..
b) Write biological source of linseed oil and kokum butter.
c) What are Pharmacy aids? Give applications of Bentonite and kaolin.
d) What are tannins? Give general properties and
classification of it.
OR
Write complete pharmacognostical account ofTurmeric and Ginger.
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PY - 204
B.Pharm. II Semester
Examination, June 2013
Pharmacognosy-I
Time Three Hours
Maximum Marks :70
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Note: Attempt any five questions. All questions carry equal marks.
l. Write down the Biological source, chemical constituents one identification test and uses of
following drugs.
i) Acacia ii) lsabgol iii) Cocoa Butter
iv)Turmeric V) Podophyllum vi) Catechu vii) Arjuna
2. What do you mean by quality control of crude drugs. Give a detail note on drug evaluation.
3. Define cultivation. What are various methods of cultivation and give a detail note on
factors affecting cultivation of medicinal plants.
4. Write the complete phannacogenetic account of
a) Tales & Peru balsam b) Guggul c) Ginger
5. Define tannins, Give the chemical tests for identification of tannins, write the complete
pharmacognosy of Amla and Ashoka.
6. a) Write note on natural pest controlling agents.
b) Write a note on classification of cmde drugs.
7. a) Define fibers. Give a detail note on animal fibers.
b) Write a note on Traditional systems of medicine.
8. Write short note on any three:
i) Umbelliferae ii) Synthetic fibers
iii) Identification tests for fats and waxes. iv) Pha.rmaceulicalAids.
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