sajany gas vortex gradientless bioreactor Сreation of highly efficient universal modular...
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SajanySajanyGas Vortex Gradientless Bioreactor
Сreation of highly efficient universal modular biotechnological complexes of a new type based on
gas vortex gradientless bioreactors
Joint Stock CompanyJoint Stock Company
630090 office 403, building 8, Nikolaeva str., Novosibirsk Tel/fax: +7 (383) 3-33-33-69; 3-33-26-01, 3-30-92-31
e-mail: [email protected], [email protected] www.bioreactor.ru
The factors affecting the vital capacity of The factors affecting the vital capacity of cultivated cells and microorganismscultivated cells and microorganisms
The factors affecting the vital capacity of The factors affecting the vital capacity of cultivated cells and microorganismscultivated cells and microorganisms
(temperature regime, breath, nutrition, metabolites, mechanical impact)
O2
O2
O2O2
O2
O2
O2O2
O2
O2
O2
O2
O2
nutritionnutrition
metabolites
cut straincut strain
cut straincut strain
Mechanical mixing Gas vortex mixing
Traditional bioreactorTraditional bioreactor: : mechanical mixingmechanical mixing
Gas vortex gradientless bioreactorGas vortex gradientless bioreactor: : gas vortex mixinggas vortex mixing
Characteristics of gas vortexCharacteristics of gas vortex gradientless gradientless bioreactorsbioreactors
Extremely low power consumption, i.e. 10-12 times less compared to bioreactors with mechanical stirrer
Cultivation of cells which are poorly reproduced in well-known types of bioreactors
High surface mass exchange rate - 6-8 (KL 1/ hour)
Efficient mixing of especially viscous fluids
Absence of local overheating areas affecting the enzymes activity
Constant operational parameters when filled with a suspension by 15%-90% of the vessel volume
Gas vortex serves as an efficient foam breaker
Bioreactor’s hydrodynamics, practically, does not depend on the liquid level inside. The bioreactor is easy to scale-up
SomeSome Cultivation Results Cultivation Results (Without Medium Substitution(Without Medium Substitution))
Besides, chicken embryo fibroblasts, VERO, hybrid A4С5 cells (a hybrid of porcine kidney cell and lymphocyte), human thymus cells (T-5) and Aristolochia manshunensis cells, Aspergillus awamori, Fusarium moniliforme and many others were successfully cultivated.
Important advantagesImportant advantages of gas vortexof gas vortex gradientless bioreactorsgradientless bioreactors
Universality – capability to operate successfully practically on all types of cells (including embryonic and hybrid ones) and microorganisms
Full repeatability (scalability) of laboratory results at industrial application of developments
High economic efficiency in commercial use
Industrial implementation of innovative Industrial implementation of innovative products and technologiesproducts and technologies
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Traditionalbioreactor
Gradientlessbioreactor
New New productproduct
New New productproduct
New New productproduct
Application of gas-vortex bioreactors Application of gas-vortex bioreactors for emergency responcefor emergency responce
Epidemics, pandemics
Emergency eliminationsEmergency eliminations
Global warmingGlobal warming
Technogenic impactTechnogenic impact
BioterrorismBioterrorism
Global warmingGlobal warming
Technogenic impactTechnogenic impact
BioterrorismBioterrorism
Appearance of Appearance of diseases diseases
unknown beforeunknown before
Express manufacturing of any type vaccines in sufficient amounts using
gas-vortex bioreactors
Developments of required vaccines
Conception ofConception of highly efficient universal highly efficient universal modular biotechnological enterprises modular biotechnological enterprises
of a new type of a new type Highly efficient universal modular biotechnological enterprise of a new type consists of: fixed highly economical “head” block of the universal gas vortex gradientless bioreactors variable modular “tail” block responsible for the processing of biological productsModules of the “tail” block can be modified and enlarged depending on the processed biological product which is got from block of gas vortex gradientless bioreactors
Universal highly efficient biotechnological Universal highly efficient biotechnological modular production facilitiesmodular production facilities
750 L750 L
1010 L L 3030 L L100100 L L
300300 LL
1010 L L 3030 L L100100 L L
300300 L L
Fermentative unit withtraditional bioreactors
Fermentative unit withgas-vortex bioreactors
750 L750 L
10 L10 L10 L10 L
10 L10 L10 L10 L
10 L10 L10 L10 L
Factors that highlight high profitability of the Factors that highlight high profitability of the new production facilitynew production facility
Minor initial investments as a results of
Reduction of the number of bioreactors in the technological chain
Making communication pipelines simpler and shorter Reduction of a total production costs (electric power, steam, detergents,
area, payment schedule etc.) Universality of the facilities, i.e. feasibility of successful operation with
producers of different types Financial stability of the enterprise as a result of rapid and low-
investment implementation of technologies for manufacture of new biotechnological products
Technological effectiveness Augmentation of the biomass yield Reduction of losses during cultivation
Field ofField of A Applicationpplication Production of medical products
(including products using very sensitive embryonic, hybrid and other cells);
Production of a broad range of microbiological preparations for agriculture and veterinary medicine;
Production of polysaccharides and oil destructors for oil-producing industry;
Manufacturing of products for food industry (treacle, glucose syrups, ferments, food supplements and etc.);
Production of surface-active agents and ferments for chemical industry;
Carrying out research efforts of different types.
Promptly-built modular biotechnological Promptly-built modular biotechnological ((pharmaceuticalpharmaceutical) industrial complexes ) industrial complexes
of a new typeof a new type
Broad application of gas-vortex bioreactors and the creation of biotechnological industrial complexes of the new type on their basis
is one of thebreakthrough trends in the field of industrial biotechnology.
Gas Vortex Gradientless Bioreactor is an apparatus of new Gas Vortex Gradientless Bioreactor is an apparatus of new generation having no analogues in the whole worldgeneration having no analogues in the whole world in terms of in terms of
the method of mixingthe method of mixing
patents of USA, Japan and 6 European countries
Gas-Vortex Gradientless Bioreactor is
acknowledged by experts to be one of the most promising
creations in the sphere of high
technologies in Russia in 2004.
In III Moscow International Congress «BIOTECHNOLOGY:
STATE OF THE ART AND PROSPECTS OF
DEVELOPMENT»Gas Vortex Gradientless
Bioreactor became the winnerin the nomination “Equipment”and was awarded gold medal at
BIOTECH WORLD’ 2005 International Exhibition.
Thank you
630090 office 403, Building 8, Nikolaeva str., Novosibirsk Tel/fax: +7 (383) 3-33-33-69; 3-33-26-01, 3-30-92-31
e-mail: [email protected], [email protected] www.bioreactor.ru
SajanySajany Joint Stock CompanyJoint Stock Company