saponin how saponin could be used to reduce the occurrence of asthma and an alternative approach in...
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SAPONINHOW SAPONIN COULD BE USED TO REDUCE THE OCCURRENCE OF ASTHMA AND
AN ALTERNATIVE APPROACH IN THE TREATMENT OF ASTHMA
Quick Review
My hypothesis
Sources of saponin
Mechanism of saponin
Methods and vivo model
Structural Formula of Saponin (Reminder)
Hypothesis
Saponin can help in the reduction of the occurrence of asthma
Aim
To examine the design of my experiment To examine the model I would use in my experiment To examine the mechanism of saponin in lung tissues of a rabbit system in more detail
Expected results
Alternative approach in the treatment of Asthma
Design
Design: In my work, I have decided to use a rabbit for my experiment. I chose a rabbit because of its basic similarities of its body system to that of humans. In this experiment, I want to use 4 samples and compare its results for evaluation. Below is the basic design of my experiment.
Saponin + + - - Patient + - + -
Key:
Saponin: + means with saponin - means without saponin
Patient: + means sick patient - means healthy patient
Expected Result
For
Saponin + Patient +
In this case, when a sick patient takes saponin, the sick patient gets treated by the saponin through the mechanism described above.
For
Saponin + Patient -
In this case, when the patient is healthy and he takes saponin, it continues the normal action of providing nutrients to the body like Vitamin K, and also fight bacteria and enhance the growth of hair.
For
Saponin - Patient +
In this case, when a sick patient does not take saponin, he remains with the blocked lungs like that of Fig. D and the patient would continue having breathing problems.
For
Saponin - Patient -
In this case, when a healthy person does not take saponin, he would live his normal life without any problem.
Mechanism
Lung Tissues Of Two Vivo Models
Fig. A: Tissue of a healthy lung of a rabbit
Fig. B: Tissue of a smoked lung of a rabbit
Potential Problems of Saponin
it increases the latent period of asthma another serious problem caused by saponin is the fact that when it is induced into the
human body, it moves directly to the blood cells and causes haemolysis of the red blood cells.
Notes and Definition of Terms
The ability of saponin to increase the latent period of asthma depends on the dose of the saponin that is taken. Researchers have proven that if a dose of 20mg/kg is taken, it increases the latent period by about 29% and if a dose 40mg/kg is taken, it increases the latent period by about 49%.
Haemolysis: Breakdown or destruction of red blood cells so that the contained haemoglobin is freed into the surrounding medium
latency period is a period in which someone is infected with a disease, but no symptoms are observable
Free radicals are molecules produced when your body breaks down food, or by environmental exposures like tobacco smoke and radiation. Free radicals can damage cells, and may play a role in heart disease, cancer and other diseases.
Alternative Approach
Garlic can be an alternative approach to curing asthma.
One nutrient that plays a key role in the ability of garlic to fight asthma is vitamin C
Vitamin C helps neutralize free radicals, unstable molecules that cause contraction of airway smooth muscles in asthma sufferers
Vitamin C is an antioxidant
Antioxidants terminate chain reactions of free radicals by removing free radical intermediates, and inhibit other oxidation reactions. They do this by being oxidized themselves, so antioxidants are often reducing agents.
Anti-Oxidants Vs. Free Radicals
Conclusion
Saponin is used in the treatment of asthma, but it also has some setbacks like its level of toxicity making Garlics the best alternative in the treatment of asthma due to the fact that they are less toxic and very effective irrespective of the dose taken. Garlic is now used in the treatment of asthma for several years now and have proven to be very effective.
Reference
Adams NP, Bestall JC, Jones PW, Lasserson TJ, Griffiths B, Cates C. (2005). Inhaled fluticasone at different doses for chronic asthma in adults and children. Cochrane Database Syst Rev, 3.
Masoli M, Weatherall M, Holt S, Beasley R. (2004). Clinical dose-response relationship of fluticasone propionate in adults with asthma. Thorax, 59(1):16-20
http://www.ncbi.nlm.nih.gov/pubmed/14694240?dopt=Abstract
Chenghua. G, Xuexi .T, Xinwei. D and Yan.Y. (2009). African Journal of Biotechnology. Studies on the expectorant, antitussive and antiasthmatic properties of asterosaponin extracted from Luidia quinaria. 8 (23), 6694-6696.
http://www.ajol.info/index.php/ajb/article/viewFile/66384/54095
Ajibade V. A., Famurewa, O. (2012). Global Journal of Medical research. Histopathological and Toxicological effects of crude saponin extract from Phyllanthus niruri, L (Syn. P. franternus. Webster) on Organs in animal studies12 (1), 31-