sarcolemmal displacement
DESCRIPTION
Sarcolemmal Displacement. Will Adams. Cardiac Myopathies. Dilated Cardiomyopathy. Physiological. medlib.med.utah.edu. Hypertrophy (concentric). medic.med.uth.tmc.edu. Individual Myocyte Geometry. H = 50nm. H = 50nm. R = 10µm. R = 16µm. L = 80µm. L = 80µm. H = 50nm. R = 10µm. - PowerPoint PPT PresentationTRANSCRIPT
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Disease Biophysics Group Will Adams 1
Sarcolemmal Displacement
Will Adams
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Disease Biophysics Group Will Adams 2
Cardiac Myopathies
Physiological
Dilated Cardiomyopathy
Hypertrophy (concentric)
medlib.med.utah.edu
medic.med.uth.tmc.edu
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Disease Biophysics Group Will Adams 3
Individual Myocyte Geometry
L = 80µm
R = 10µm
H = 50nm
L = 80µm
R = 16µm
H = 50nm
L = 110µm
R = 10µm
H = 50nm
PhysiologicalConcentric Hypertrophy
Dilated Cardiac Myopathy (eccentric hypertrophy)
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Disease Biophysics Group Will Adams 4
Displacement
• Why displacement?– Mechanical energy
dissipated from internal viscosity will depend on displacement and velocity
– Perhaps the pathological morphology of the heart is maladaptive not only on a macroscale (ejection fraction) but on a microscale (intracellular drag)
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Disease Biophysics Group Will Adams 5
Longitudinal Displacement
Stress Displacement
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Disease Biophysics Group Will Adams 6
Longitudinal Displacement
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Disease Biophysics Group Will Adams 7
Transverse Displacement
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Disease Biophysics Group Will Adams 8
Results
SystoleDiastole Hypertension
Critical Ejection Fraction
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Disease Biophysics Group Will Adams 9
Directions• Maintain cytosolic volume conservation • Intregrate a t-tubule network into ABAQUS
http://mednote.co.kr/
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Disease Biophysics Group Will Adams 10
Acknowledgements
• Adrian Podpirka