Yearbook 2013

Society of Academic and Research Surgery

SARS Council ending 10 January 2013

From left to rightBack row: Bijan Modarai, Ajith Siriwardena, Steve White, Charles Knowles, Vimal Gokani, Dileep Lobo, Robert Hinchliffe

Front row: Sarah Watts, Alun Davies, Andrew Bradley, Cliff Shearman, Sarah King

ANNuAl meetiNg 2013 1

Up to 6pm, 10 January 2013

Executive Committee Name DemitsPresident Professor J A Bradley 2013President Elect Professor C Shearman 2013Honorary Secretary Professor A Davies 2015Honorary Treasurer Dr S Watts 2015Editorial Secretary Mr R Hinchliffe 2015

Sub Committees and ChairmenProgramme Chair Professor D Lobo 2014Membership Chair Dr M Loizidou 2014

Committee MembersCouncil Member Professor M Nicholson 2014Council Member Mr B Modarai 2015Council Member Professor C Knowles 2015Council Member Professor S White 2015Council Member Professor A Siriwardena 2015BAUS Rep Professor R Pickard 2014ASiT Rep Mr V Gokani

From 6pm, January 10th 2013

President Professor C Shearman 2015President-Elect Professor D Morton 2015

THE CONSTITUTION OF THE SARS COUNCIL

ANNuAl meetiNg 20132

CONTENTS LIST

Welcome from the President 3Foreword by Local Organisers 5Programme Overview: Wednesday 9 January 6Programme Overview: Thursday 10 January 8Symposium: Venous Thrombosis 10Oral presentations: Breast Surgery 11Oral presentations: Colorectal Surgery 12Oral presentations: Hepatobiliary Surgery 13Patey Prize 1 14Oral presentations: Training and Education 15Oral presentations: Vascular Surgery 1 15Oral presentations: Trauma And Orthopaedics 16SUS, SRS(SA) and ESSR Prize Winners’ Presentation 16Oral presentations: Transplantation 17

Oral presentations: Miscellaneous 18Oral presentations: Posters of Distinction 19John Farndon Lecture 20Annual General Meeting of SARS 20ASIT Symposium 20Medical Student Prize 21Oral presentations: Miscellaneous 2 22RSM Section of Surgery MIA Prize 23Oral presentations: Vascular Surgery 2 24Oral presentations: Upper GI 25Patey Prize 2 26Zachary Cope Lecture 27BJS Lecture 27Presentation of Prizes 27

Date for your Diary 27Poster Presentations – Displayed in the Atrium 28BAUS Section of Academic Urology Meeting 31BBA Programme 34Profiles of SARS Council Members 2012 36Profile: Mr Frank Smith 41Guest Speaker Profiles 42Honorary Secretary’s Report 44Honorary Treasurer’s Report 44Annual SARS Account – Year End 2011 45Prize Recipients 2012 46SARS Past Presidents and Honorary Secretaries 47Constitution of SARS 49The Royal Society of Medicine 50

ANNuAl meetiNg 2013 3

WELCOME FROM THE PRESIDENT

I am delighted to welcome you to the 61st annual scientific meeting of The Society for Academic and Research Surgery (SARS), which is held jointly for the first time with the Section of Surgery at the Royal Society of Medicine (RSM). Professor Alun Davies, the Honorary Secretary and Local Organiser for SARS, and Mr Frank Smith, the President of the Section of Surgery at the RSM, have worked together to organise what will undoubtedly be an excellent meeting in this superb venue in the heart of London’s West End.

The scientific programme has been overseen by Professor Dileep Lobo, Programme Chair of SARS, and is outstanding. It aims to promote the best surgically relevant research across the entire field, from basic laboratory research to clinical trials and health service research. The quality of the submitted abstracts was particularly high this year

and allowed us to select a large number of abstracts for presentation, covering a wide range of surgical disciplines. There are numerous prizes to be awarded that will add to the interest of the meeting. The David Patey Prize, the most prestigious award of SARS, will be given to the person judged to have given the best presentation. The RSM Section of Surgery MIA Prize will be awarded to the best presentation in the RSM Prize session. The SARS Norman Williams Prize for the best clinical and translational research presentation and the SARS Kevin Burnand Prize for the best basic and experimental science presentation will be awarded to those considered most outstanding in any other oral presentation session. This year there is, for the first time, a prize for the best presentation in the session allocated to the highest scoring abstracts presented by medical students. Finally there will be prizes for the best Poster of Distinction and the best poster.

The invited named lectures are always a highlight of the annual meeting and this year the John Farndon Memorial Lecture will be given by Professor Arnie Hill, and the British Journal of Surgery Lecture will be given by Professor Norman Williams, President of the Royal College of Surgeons of England and Past President of SARS.

SARS greatly values the close links it has established with a number of specialist surgical societies. The British Association of Urological Surgeons (BAUS) Section of Academic Urology are, once again, holding a scientific meeting alongside us and have also selected two of their highest ranked papers for presentation in the Patey Prize session. Additionally, Professor David Neal will give The Royal College of Surgeons of England’s prestigious Zachary Cope Lecture. The Association of Surgeons in Training (ASiT) and the British Burns Association are also holding satellite symposia alongside SARS and we very much welcome their presence. It is a particular pleasure to welcome to London the representatives from our three sister societies, the Society of University Surgeons in the United States, the Surgical Research Society of Southern Africa and the European Society of Surgical Research.

This joint meeting of SARS and the Section of Surgery of the RSM provides an outstanding opportunity for delegates to share the latest findings in surgical research and also socialise with like-minded surgeons and scientists, all while enjoying the wonderful hospitality provided by the local organisers.

This is my last meeting as SARS President and I am extremely grateful for the support received from all members of Council over the past two years. Particular thanks are due to Sarah King in the SARS office at the Royal College of Surgeons for her outstanding administrative support. It has been a privilege to serve as your President: SARS is in excellent health and I am confident that under the direction of the next President, Professor Cliff Shearman, it will go from strength to strength.

Andrew Bradley President

4

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Would you like to be awarded an RCS research fellowship?

If you are a subscribing fellow or member of the Royal College of Surgeons of England in a training post, or, a trainee who has passed the MCQ papers and will sit the fi nal MRCS examination at this College, you are eligible to apply.

The fellowships cover salary, on-costs and some running expenses. Applicants may study any aspect of surgery or surgical care including basic science, diagnosis, treatment, surgical technology, logistics or audit. The main criteria for those interested in applying are to delineate important research questions, with an appropriate study design that can be completed within the year of the fellowship. The research can also be self-contained or part of a wider research programme.

The supervisor plays a key role in helping with the writing and structure of the application, as well as offering support during the research year.

Each fellowship is worth up to £60,000, which includes salary, National Insurance and other contributions, as well as an additional amount for consumables. All applications are rigorously assessed by a panel of experts to ensure that the research, the surgeon, the supervisor and the facilities are of a high standard, and that the proposed work will be valid, benefi cial and original.

At the end of each period of research, the fellow is asked to contribute an evaluation and a report along with details of publications and presentations.

Closing date: 5pm, 28 February 2013

For more details:e: research@rcseng.ac.ukw: www.rcseng.ac.uk/surgeons/research/fellowships/research-old.html

5

FOREWORD BY LOCAL ORGANISERS

London 2013

We would like to welcome you to the first joint meeting of the Society of Academic and Research Surgery and the Section of Surgery at the Royal Society of Medicine.

This is the foremost surgical scientific meeting in the United Kingdom and this year takes place in the prestigious venue of the Royal Society of Medicine at 1 Wimpole Street, London.

The meeting programme contains over 160 excellent scientific presentations representing many surgical specialties, together with talks from respected experts who will deliver keynote British Journal of Surgery, John Farndon, and the Royal College of Surgeon’s Zachary Cope lectures. The Gala Dinner will give you the opportunity to relax and socialise with your peers and colleagues in convivial surroundings.

We hope you will enjoy your visit to London and make the most of all the academic and social opportunities that this joint meeting has to offer!

Alun DaviesHonorary Secretary,Society of Academic and Research Surgery

Frank SmithPresident,Section of Surgery,The Royal Society of Medicine

6

07.30 08.00 08.30 09.00 09.30 10.00 10.30 11.00 11.30 12.00 12.30 13.00

Max Rayne Auditorium

Wimpole Lecture

Theatre

Guy Whittle

Auditorium

Other

SARS PROGRAMME OVERVIEW: WEdnESdAy 9 JAnuARy

Registration Coffee, Trade ExhibitionAtrium

11.20–11.50

Lunch, Trade Exhibition and Poster JudgingAtrium

13.00–14.00

Parallel Oral Presentations13 papers (5 min + 2min)

1A. Breast Surgery09.40–11.20

Patey Prize 17 papers (7 min + 3min)

11.50–13.00

Parallel Oral Presentations14 papers (5 min + 2min)

1B. Colorectal Surgery09.40–11.20

WelcomeProf J Andrew Bradley, Mr Frank Smith and Prof Alun Davies

08.15–08.20

Followed by

Symposium: Venous thrombosis08.20–09.40

Parallel Oral Presentations14 papers (5 min + 2min)

1C. Hepatobiliary Surgery09.40–11.20

Page 10

Page 13

Page 14

Page 12

Page 11

7

14.00 14.30 15.00 15.30 16.00 16.30 17.00 17.30 18.00 18.30 19.00+

Max Rayne Auditorium

Wimpole Lecture

Theatre

Guy Whittle

Auditorium

Other

Coffee, Trade ExhibitionAtrium

15.30–16.00

Pre-dinner DrinksAtrium

19.00

Gala Dinner19.30

Parallel Oral Presentations8 papers (5 min + 2min)

2C. Trauma and Orthopaedics14.00–15.00

Parallel Oral Presentations15 papers (3 min + 2min)

3C. Posters of Distinction16.00–17.30

Parallel Oral Presentations8 papers (5 min + 2min)

2A. Training and Education14.00–15.00

Parallel Oral Presentations12 papers (5 min + 2min)

3A.Transplantation16.00–17.30

Parallel Oral Presentations8 papers (5 min + 2min

2B. Vascular Surgery

14.00–15.00

Parallel Oral Presentations12 papers (5 min + 2min

3B. Miscellaneous 116.00–17.30

John Farndon LectureBreast Surgery – What is the future?

Prof ADK Hill

17.30–18.00

SUS, SRS (SA) and ESSR Prize Winners’ Presentation (7 min + 3 min) 15.00– 15.30

Page 15

Page 19

Page 18

Page 17

Page 15

Page 16

Page 19

Annual General Meeting18.00–18.30

Page 20

Page 20

8

07.30 08.00 08.30 09.00 09.30 10.00 10.30 11.00 11.30 12.00 12.30 13.00

Max Rayne Auditorium

Wimpole Lecture

Theatre

Guy Whittle

Auditorium

Other

SARS PROGRAMME OVERVIEW: ThuRSdAy 10 JAnuARy

Registration Coffee, Trade ExhibitionAtrium

10.15–10.45

Lunch, Trade ExhibitionAtrium

13.15–14.00

Parallel Oral Presentations8 papers (5 min + 2min)

5B. Upper GI12.15–13.15

Parallel Oral Presentations8 papers (5 min + 2min)

4B. Miscellaneous08.45–09.45

ASiT symposiumDebate: A doctorate degree is necessary for progress in the current training system

08.00–08.45

Parallel Oral Presentations11 papers (5 min + 2min)

4A. Medical Student PrizeO8.45–10.15

Parallel Oral Presentations8 papers (5 min + 2min)

5A. Vascular Surgery 212.15–13.15

RSM Section of Surgery MIA Prize10 papers (6min + 3min)

10.45–12.15

Page 21

Page 20

Page 23

Page 24

Page 22

Page 25

9

14.00 14.30 15.00 15.30 16.00 16.30

Max Rayne Auditorium

Wimpole Lecture

Theatre

Guy Whittle

Auditorium

Other

Coffee, Trade ExhibitionAtrium

15.10–15.30

Zachary Cope Lecture The androgen receptor and prostate cancer

Prof D Neal

15.30– 16.00

BJS LectureAttempts to innovate in coloproctology and beyond

Prof N Williams

16.00– 16.30

Presentation of Prizes16.30–16.50

Patey Prize 27 papers (7 min + 3 min)

14.00–15.10

Page 26

Page 27

Page 27

Page 27

WED

NES

DAY

10

SYMPOSIUM: VENOUS THROMBOSISGuy Whittle Auditorium | Chairs: Professor Alun Davies and Mr Frank Smith

08.20 New agents in VTE treatment Beverley HuntProfessor of Thrombosis and Haemostasis, King’s College London08.40Impact of NICE VTE GuidelinesGerard StansbyProfessor of Vascular Surgery, University of Newcastle09.00VTE prophylaxis international opinionAndrew NicholaidesEmeritus Professor of Vascular Surgery, Imperial College; Director of Vascular Noninvasive Diagnostic Centre, London 09.20–09.40Discussion

11

WED

NES

DAYBREAST SURGERY

Parallel Oral Presentations 1A | Max Rayne Auditorium | Chairs: Professor Arnold Hill and Professor John Robertson

09.40O36: IMPORTANCE OF MONITORING BONE HEALTH IN BREAST CANCER O Choudhry2, L Olson1, Z Saad1, S Chatterjee1

1Salford Royal Foundation Trust; 2University of Manchester Medical School

09.47O37: TRIALS THAT CONSIDER OMITTING AXILLARY CLEARANCE IN PATIENTS WITH POSITIVE AXILLARY SENTINEL NODE BIOPSY COULD POTENTIATE UNDER TREATMENT T Hussain, K Grover, T Mahapatra, PL McManus, A Dhadda, PJ KneeshawCastle Hill Hospital, East Riding of Yorkshire NHS Trust

09.54O38: IDENTIFICATION AND VALIDATION OF A MICRORNA SIGNATURE ASSOCIATED WITH BREAST CANCER PROGRESSION PS Waters, RM Dwyer, P Hyland, C Brougham, D Wall, MJ KerinDiscipline of Surgery, Clinical Science Institute, University College Hospital, Galway, Ireland

10.01O39: DEFINING THE VALUE OF DIAGNOSTIC AXILLARY ULTRASOUND IN EARLY BREAST CANCER – A CONTEMPORARY COHORT ANALYSIS. H Tuffaha, A Gardiner, A Lee, M Reis, D Brown, A Evans, A ThompsonNinewells University Hospital, Dundee

10.08O40: SURVIVIN EXPRESSION IN MALE BREAST CANCER SS Rajan1,2, AM Hanby1,2, K Horgan2, V Speirs1 1The Male Breast Cancer Consortium, Leeds Institute of Molecular Medicine, University of Leeds; 2Leeds Teaching Hospitals NHS Trust, Leeds

10.15O41: THE INFLUENCE OF INTRINSIC TUMOUR SUBTYPE ON BREAST CANCER SURVIVAL JW Walsh, AM McDermott, PS Waters, MJ KerinDiscipline of Surgery, National University of Ireland, Galway

10.22O42: CONVENTIONAL VERSUS ULTRASOUND-ASSISTED LIPOSUCTION IN GYNAECOMASTIA SURGERY: A 13-YEAR REVIEW KY Wong, CM MalataCambridge University Hospitals NHS Foundation Trust

10.29O43: MIR-15 FAMILY MICRORNAS: ABERANT EXPRESSION IN BREAST CANCER AM McDermott, HM Heneghan, D Wall, N Miller, MJ Kerin Discipline of Surgery, National University of Ireland, Galway

10.36O44 : PSMD9 EXPRESSION PREDICTS LOCAL RECURRENCE FOLLOWING RADIOTHERAPY IN BREAST CANCER FE Langlands1,2, D Dodwell3, AM Hanby4, K Horgan2, RA Millican-Slater 4, ET Verghese 1,4, L Smith1, TA Hughes1

1Leeds Institute of Molecular Medicine, University of Leeds; 2Department of Surgery, Leeds General Infirmary; 3St James’s Institute of Oncology, St James’s University Hospital; 4Department of Histopathology, St James’s University Hospital, Leeds

10.43O45: A COMBINED ANALGAESIC/ANAESTHETIC INTERVENTION: EVAULATING ITS EFFECTIVENESS FOR THE REDUCTION OF POSTOPERATIVE PAIN AFTER BREAST CANCER SURGERYJ Wormald, A Figus, W Notcutt, J Pereira Norwich Medical School, University of East Anglia

10.50O46: PRACTICAL GUIDANCE FOR SELECTION OF SENTINEL NODE POSITIVE PATIENTS FOR FURTHER AXILLARY SURGERYH Tuffaha, A Gardiner, A Lee, M Reis, D Brown, K Thompson, A ThompsonNinewells University Hospital, Dundee

10.57O47: SENTINEL LYMPH NODE BIOPSY – ARE WE DOWNSTAGING THE AXILLA? ZM Jessop, M Oyewole, S Deeba, ED BabuDepartment of General Surgery, Hillingdon Hospital

11.04O48: ASSESSMENT OF THE AXILLA IN BREAST CANCER TREATED WITH NEOADJUVANT CHEMOTHERAPY – HOW AND WHEN? T McVeigh, D Al-Azawi, DE Kearney, C Malone, K Barry, KJ Sweeney, M Keane, R McLaughlin, MJ Kerin Galway University Hospital

12

WED

NES

DAY COLORECTAL SURGERY

Parallel Oral Presentations 1B | Wimpole Lecture Theatre | Chairs: Professor Charles Knowles and Professor John Macfie

09.40O49: AWARENESS AND UPTAKE OF FAMILY SCREENING IN PATIENTS DIAGNOSED WITH COLORECTAL CANCER AT A YOUNG AGE M Hanley1, NM Hogan1, M Sheehan2, OJ McAnena1, M Regan1, MR Joyce 3

1Discipline of Surgery, School of Medicine, National University of Ireland, Galway; 2Department of Histopathology and 3Department of Colorectal Surgery, University Hospital Galway 2

09.47O50: NEUTROPHIL-LYMPHOCYTE RATIO (NLR) AS A SIMPLE AND NOVEL BIOMARKER IN PREDICTING LOCOREGIONAL RECURRENCE AFTER CHEMOTHERAPY FOR SQUAMOUS CELL CARCINOMA (SCC) OF THE ANUS E-W Toh, J Wilson, I Botterill, D Sebag-MontefioreThe John Goligher Colorectal Unit, St James’s University Hospital, Leeds

09.54O51: INTERACTIONS BETWEEN MESENCHYMAL STEM CELLS (MSCS) AND COLORECTAL CANCER CELLS ARE MEDIATED BY PLASMINOGEN ACTIVATOR INHIBITOR TYPE 1 (PAI-1) NM Hogan1, RM Dwyer1, MR Joyce2 MJ Kerin1

1Discipline of Surgery, School of Medicine, National University of Ireland, Galway and 2Department of Colorectal Surgery, University Hospital Galway

10.01O52: KRAS MUTATION AND ITS EFFECT ON OUTCOME AFTER NEOADJUVANT CHEMORADIOTHERAPY IN RECTAL CANCER: A META-ANALYSIS C Clancy, JP Burke, JC CoffeyUniversity Hospital Limerick

10.08O53: CROHN’S DISEASE: A POPULATION ANALYSIS OF CHANGING TRENDS IN HOSPITAL ADMISSION AND SURGICAL INTERVENTION 1995–2009 HM Mohan, AC Rogers, DC WinterDepartment of Surgery, St Vincent’s University Hospital, Elm Park, Dublin 4, Ireland

10.15O54: INCREASED DERMAL ELASTIC FIBRES IN PATIENTS WITH RECTAL PROLAPSE HMN Joshi, EA Smyth, O Jones, C Cunningham, J Urban, I Lindsey Oxford Pelvic Floor Centre

10.22O55: ANALYSIS OF COLON DAMAGE AND RECOVERY FOLLOWING APPLICATION OF A MECHANICAL STRESS J Barrie1, S Hafeji, P Culmer1, A Neville1, DG Jayne2

1School of Mechanical Engineering, The University of Leeds; 2Division of Clinical Sciences, Leeds Institute of Molecular Medicine, The University of Leeds

10.29O56: A POTENTIAL PATHWAY LINKING INFLAMMATION TO MIR-21 ACTIVATION AND PDCD4 DOWNREGULATION IN COLORECTAL CANCERO Peacock, F Cameron, A Lee, C Tufarelli, J LundDivision of Surgery, School of Graduate Entry Medicine & Health, University of Nottingham, Royal Derby Hospital

10.36O57: COMPARISON OF ANAL EVOKED POTENTIALS ELICITED BY MECHANICAL AND ELECTRICAL STIMULI IN ANAESTHESISED RATSJ Evers1, EV Carrington1,2, SM Scott2, CH Knowles3, PR O’Connell4, JFX Jones1

1School of Medicine and Medical Science, University College Dublin, Dublin, Ireland; 2GI Physiology Unit, The Wingate Institute of Neurogastroenterology and 3National Centre for Bowel Research and Surgical Innovation, Queen Mary, University of London, London; 4Centre for colorectal disease, St Vincent’s University Hospital, Dublin, Ireland

10.43O58: CARCINOEMBRYONIC ANTIGEN (CEA) IS A HIGHLY SPECIFIC AND SENSITIVE MARKER FOR COLORECTAL CANCER IN VIVO IMAGING OR TARGETED DELIVERY APPLICATIONS AND OUTPERFORMS OTHER CANDIDATE MARKERSJP Tiernan1,2, SL Perry1, ET Verghese1,2, NP West1,2, S Yeluri2, DG Jayne1,2, TA Hughes1

1Leeds Institute of Molecular Medicine, 2Leeds Teaching Hospitals

10.50O59: DOES TUMOUR TATTOOING IN COLORECTAL SURGERY AFFECT LYMPH NODE YIELD? RM Evans, P Mummugati, M Davies, MD Evans, TV Chandrasekaran, U Khot, J Beynon, DA HarrisDept of Surgery, Singleton Hospital, Swansea

10.57O60: REPORTING OF LONG-TERM SURVIVAL AND ONCOLOGICAL OUTCOMES OF COLORECTAL CANCER SURGERY: A SYSTEMATIC REVIEW RO Forsythe1, RN Whistance1,2, AGK McNair2, ST Brookes2, K Avery2, AM Pullyblank3, DG Jayne4, JM Blazeby1,2 on behalf of the CONSENSUS-CRC (Core Outcomes and iNformation SEts iN SUrgical Studies – ColoRectal Cancer) working group.1Division of Surgery Head and Neck, University Hospitals Bristol NHS Foundation Trust; 2Academic Unit of Surgical Research, School of Social and Community Medicine, University of Bristol; 3Department of General Surgery, North Bristol NHS Trust; 4Academic Surgical Unit, St James’ University Hospital NHS Trust, Leeds

11.04O61: SYSTEMIC INFLAMMATORY RESPONSE IS PREDICTIVE OF OUTCOME IN PATIENTS UNDERGOING SURGERY FOR LOCALLY RECURRENT RECTAL CANCER DP Harji, B Griffiths, J Sarveswaran, M Evans, A Koshy, PM SagarSt James’s University Hospital, Leeds

11.11O62: GENETIC AND EPIGENETIC FACTORS IN PREDICTION OF RESPONSE OF RECTAL ADENOCARCINOMA TO NEOADJUVANT CHEMORADIATION JS Williamson, WN Williams, AP Griffiths, C Davies, GJ Jenkins, J Beynon, DA Harris Department of Colorectal Surgery, Abertawe Bro Morgannwg University Health Board

13

WED

NES

DAYHEPATOBILIARY SURGERY

Parallel Oral Presentations 1C | Guy Whittle Auditorium | Chairs: Mr Ashley Dennison and Professor John Primrose

09.40O63: INCREASED EXPRESSION OF TOLL-LIKE RECEPTOR (TLR) 4 AND TLR5 FOLLOWING COMPLEX HEPATO-PANCREATICO-BILIARY (HPB) SURGERY PREDICTS THE DEVELOPMENT OF POSTOPERATIVE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME (SIRS)R Lahiri 1,2, J Wong1, J Waters1, S Bhattacharya2, G Foster1, W Alazawi11Department of Hepatology, Centre for Digestive Diseases, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London; 2Barts and the London HPB Centre, Barts Health NHS Trust

09.47O64: DOES SEQUENTIAL COMPLETE EMBOLIZATION OF INFLOW TO LIVER RESULT IN IMPROVED FLR AUGMENTATION? R Lochan1, S Robinson1, JJ French1, BC Jaques1, J Rose2, RM Charnley1, DM Manas1, SA White1

1Department of HPB Surgery and 2Radiology, Freeman Hospital

09.54O65: PROGNOSTIC IMPLICATIONS OF TUMOUR-ASSOCIATED LYMPHOCYTES IN PANCREATIC DUCTAL ADENOCARCINOMA AND EXTRAHEPATIC CHOLANGIOCARCINOMA N Tewari1,3, AM Zaitoun2,3, A Arora4, S Madhusudan4, M Ilyas2 DN Lobo1,3

1Division of Gastrointestinal Surgery, University of Nottingham; 2Department of Cellular Pathology, Nottingham University Hospitals NHS Trust; 3NIHR Nottingham Digestive Diseases Centre Biomedical Research Unit; 4Academic Oncology, University of Nottingham, School of Molecular Medical Sciences, Nottingham University Hospitals NHS Trust

10.01O66: PANCREATICO-DUODENECTOMY WITH VASCULAR RESECTION FOR LOCALLY ADVANCED PANCREATIC CANCER. IS THERE A SURVIVAL ADVANTAGE? A Amer, J French, B Jaques, R Charnley, D Manas, S WhiteNewcastle upon Tyne Hospitals NHS Trust

10.08O67: ONCOLOGICAL FEASIBILITY OF LAPAROSCOPIC DISTAL PANCREATECTOMY FOR ADENOCARCINOMA OF DISTAL PANCREAS: A SINGLE-INSTITUTION COMPARATIVE STUDY S Rehman, R Lochan, JJ French, BC Jaques, DM Manas, SA White Department of Hepatobiliary Surgery, Freeman Hospital

10.15O68: ANATOMICAL VARIATION IN THE INFERIOR PANCREATICODUODENAL ARTERIES AND ITS RELEVANCE TO PANCREAS TRANSPLANTATION R Al-Biatty, University of Leeds

10.22O69: COLORECTAL LIVER METASTASES – WHICH DIAGNOSTIC IMAGING MODALITY IS BEST? A Kontoyannis1–3, S O’Connell1, S Berendse1, G Poston1,4, R Hargest1,2,5

1National Collaborating Centre for Cancer; 2Cardiff University; 3University Hospital Lewisham; 4University Hospital Aintree; 5University Hospital Wales

10.29O70: IDENTIFICATION OF MOLECULAR PATHWAYS IMPLICATED IN THE PATHOGENESIS OF OXALIPLATIN INDUCED SINUSOIDAL OBSTRUCTION SYNDROME SM Robinson1,2, J Mann1, DM Manas2, DA Mann1, SA White1,2

1Institute of Cellular Medicine, Newcastle University; 2Department of HPB Surgery, Freeman Hospital, Newcastle upon Tyne

10.36O71: A STUDY OF HEPATOCYTE ISCHAEMIA-REPERFUSION INJURY AND STEATOSIS IN A HUMAN LIVER STEM CELL MODEL PC Sivathondan1, L Hodson2, RA Dragovic1, MA Silva3, PJ Friend3, KJ Morten1 1Nuffield Department of Obstetrics and Gynaecology; 2Oxford Centre for Diabetes, Endocrinology and Metabolism; 3Nuffield Department of Surgical Sciences, University of Oxford

10.43O72: KLF6 SPLICE VARIANT 1 IN PATIENTS WITH COLORECTAL LIVER METASTASIS CORRELATES WITH A HIGHER CLINICAL RISK SCORE KYD Hui1, S Robinson2, GL Patman1, D Manas2, H Reeves1, SA White2

1Newcastle University, Northern Institute for Cancer Research, Newcastle-upon-Tyne; 2The Freeman Hospital, Department of HPB and Transplant Surgery, Newcastle-upon-Tyne

10.50O73: ANTIOXIDANT THERAPY IS ABLE TO PREVENT THE DEVELOPMENT OF OXALIPLATIN INDUCED SINUSOIDAL OBSTRUCTION SYNDROME SM Robinson1,2, JJ Mann1, A Vasilaki3, DM Manas2, DA Mann1, SA White 1,2

1Institute of Cellular Medicine, Newcastle University; 2Department of HPB Surgery, Freeman Hospital, Newcastle upon Tyne; 3Institute of Ageing and Chronic Disease, University of Liverpool

10.57O74: IN VIVO ALTERATIONS TO CHOLANGIOCYTE MICROVILLI AND BILE COMPOSITION IN RESPONSE TO HEPATIC ISCHAEMIA-REPERFUSION INJURY A Amer, M Wright, S WhiteInstitute of Cellular Medicine, Newcastle University, Newcastle upon Tyne

11.04O75: DO MULTIPLE DEPRIVATION INDEX SCORES CORRELATE WITH THE PREVALENCE AND OUTCOME OF PANCREATIC AND PERIAMPULLARY CANCER IN WEST YORKSHIRE? M Hamed, J Pine, AM Smith, GM Stiff The Pancreatic Unit, St James’s University Hospital, Beckett Street, Leeds

11.11O76: THE EFFECT OF HYPOXIC STRESS ON ACTIVATED HEPATIC STELLATE CELL CHEMOTAXIS IN VITRO A Amer, D Manas, M Wright, S WhiteNewcastle University

14

WED

NES

DAY PATEY PRIZE 1

Guy Whittle Auditorium | Chairs: Professor Andrew Bradley and Professor Cliff Shearman

11.50O1:NEOADJUVANT CHEMOTHERAPY INDUCES CHANGES IN EXPRESSION OF BREAST CANCER RESISTANCE PROTEIN THAT PREDICT DISEASE-FREE SURVIVAL IN BREAST CANCER B Kim1,3, BJ Williams2, H Fatayer3, AM Hanby1,2, K Horgan3, JL Thorne1, EMA Valleley1, ET Verghese1,2, TA Hughes1

1Leeds Institute of Molecular Medicine, University of Leeds, Leeds; 2Department of Histopathology, St James’s University Hospital, Leeds; 3Department of Breast Surgery, Leeds General Infirmary, Leeds

12.00O2: THE SIGNIFICANCE OF OESTROGEN RECEPTORS IN OESOPHAGEAL CANCER DEVELOPMENT W Al-Khyatt, C Tufarelli, R Khan, SY IftikharSchool of Graduate Entry Medicine and Health, University of Nottingham, Royal Derby Hospital, Uttoxeter Road, Derby

12.10O3: AN OMEGA-3 RICH LIPID EMULSION IS ASSOCIATED WITH IMPROVED CLINICAL OUTCOME IN PATIENTS WITH SEVERE ACUTE PANCREATITIS: A RANDOMISED DOUBLE-BLIND CONTROLLED TRIAL D Al-Leswas, A Arshad, A Eltweri, WY Chung, O Al-Taan, C Pollard, M Metcalfe, AR DennisonHepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester

12.20O4: IDENTIFICATION OF IL8 AND TIMP4 AS MOLECULAR PHENOTYPIC DESCRIPTORS OF BREAST CAPSULAR CONTRACTURE FORMATION USING INFORMATICS ANALYSIS OF THE WHOLE GENOME TRANSCRIPTOME D JT Kyle1, AG Harvey1, B Shih1, KT Tan1, IH Chaudhry4, A Bayat1,2,3

1Plastic & Reconstructive Surgery Research, Manchester Interdisciplinary Biocentre, University of Manchester; 2Department of Plastic and Reconstructive Surgery, University Hospital South Manchester Foundation Trust, Wythenshawe Hospital; 3The University of Manchester, Manchester Academic Health Science Centre, University Hospital South Manchester Foundation Trust, Wythenshawe Hospital; 4Department of Laboratory Medicine, Central Manchester NHS Foundation Trust, Manchester

12.30O5: AVAILABILITY OF T CELL HELP DETERMINES ALLOANTIBODY LEVELS AND GRAFT OUTCOME IN A MURINE MODEL OF ANTIBODY-MEDIATED REJECTION M Chhabra, CJ Callaghan, S Rehakova, MC Negus, EM Bolton, JA Bradley, GJ Pettigrew Department of Surgery, University of Cambridge

12.40O6: IRON CHELATION IN THE TREATMENT OF OESOPHAGEAL ADENOCARCINOMA – IN-VIVO ACTION OF DEFERASIROX ON A XENOGRAFT MODEL SJ Ford1, MR Bedford1, O Tucker2, T Iqbal1, D Alderson2, C Tselepis1

1Cancer Research UK Institute for Cancer Studies, University of Birmingham; 2University Hospital Birmingham

12.50O7: GENERATION OF HLA-SPECIFIC HUMANISED MICE USING BONE MARROW-DERIVED HAEMATOPOIETIC STEM CELLS FROM CADAVERIC ORGAN DONORS KM Elliott1, TM Conlon1, M Negus1, FJ Rouhani2, L Vallier2, EM Bolton1, JA Bradley1, GJ Pettigrew1, K Saeb-Parsy1

1Department of Surgery, University of Cambridge; 2Laboratory of Regenerative Medicine, University of Cambridge

15

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NES

DAYTRAINING AND EDUCATION

Parallel Oral Presentations 2A | Wimpole Lecture TheatreChairs: Dr Marilena Loizidou and Miss Rachel Hargest14.00O77: BRIDGING THE SIMULATION GAP - HOW ARE LAPAROSCOPIC SURGICAL SIMULATORS CURRENTLY PERCEIVED BY TRAINED SURGEONS AND SURGEONS IN TRAINING PM Brennan1, JJM Loan2, RW Partridge3

1Department of clinical neuroscience, Western General Hospital, Edinburgh; 2College of Medicine, Chancellor’s Building, University of Edinburgh; 3Department of Paediatric Surgery, Royal Hospital for Sick Children, Glasgow

14.07O78: AUDITING PERFORMANCE – WHAT DOES THE TICK IN THE BOX ACTUALLY MEAN? ER Robertson, L Morgan, S New, P McCullochUniversity of Oxford

14.14O79: QUANTIFYING SURGICAL TEACHING: THE STTAR (STRUCTURED TRAINING TRAINER ASSESSMENT TOOL) SM Wyles1, D Miskovic1, M Ni1, MG Coleman2, AW Darzi1, GB Hanna1

1Academic Surgical Unit, Imperial College, St Mary’s Campus, London; 2Lapco National Office, Derriford Hospital, Plymouth

14.21O80: ANATOMY KNOWLEDGE IN CORE SURGICAL TRAINEES T Jennison, W Midlands Deanery

14.28O81: A PROSPECTIVE SURVEY OF SURGICAL HANDOVER PRACTICES AND OUTCOMES IN THE UNITED KINGDOM Q Frew, C Allen, S Siddiqui, J Ford, J Akhtar, S DeSouza, M GriffithsSt Andrews Burns Unit

14.35O82: THE IMPORTANCE OF CASE SELECTION IN THE ENGLISH NATIONAL TRAINING PROGRAMME FOR LAPAROSCOPIC COLORECTAL SURGERY (LAPCO) H Mackenzie1, D Miskovic1, M Ni1, M Coleman2, G Hanna1

1Imperial College, London; 2Derreford Hospital, Portsmouth

14.42O83: IMPLICATIONS OF RATIONING AND THE EUROPEAN WORKING TIME DIRECTIVE ON AESTHETIC BREAST SURGERY: A STUDY OF TRAINEE EXPOSURE IN 2005 AND 2011 N Mabvuure1,2, M-J Hallam2, S Lo2, C Nduka2

1Brighton and Sussex Medical School, Brighton; 2Queen Victoria Hospital, Holtye Road, East Grinstead

14.49O84: THE ACQUISITION AND RETENTION OF COMPLEX CLINICAL PROCEDURAL SKILLS AMONGST MEDICAL STUDENTS – TEACHING METHOD OR STUDENT TRAITS? DP Mitchell, PS Waters, G Flaherty, B Kelly, D Devitt, MJ KerinDiscipline of Surgery, Clinical Science Institute, University College Hospital, Galway, Ireland

VASCULAR SURGERY 1Parallel Oral Presentations 2B | Guy Whittle AuditoriumChairs: Mr Matt Bown and Miss Sophie Renton14.00O85: TIE2-EXPRESSING MONOCYTES ARE KEY REGULATORS OF REVASCULARISATION IN THE ISCHAEMIC LIMB AS Patel1, A Smith1, S Nucera2, F Pucci 2, P Saha1, J Humphries1, K Mattock1, RQ Attia1, S Grover1, OTA Lyons1, S Egginton3, R Siow1, A Ivetic1, M Waltham1, M De Palma2, B Modarai1 1Academic Department of Surgery, Cardiovascular Division, King’s College London and the Biomedical Research Centre at Guy’s & St Thomas’ NHS Foundation Trust and King’s College London; 2San Raffaele-Telethon Institute for Gene Therapy, Milan; 3University of Birmingham Medical School

14.07O86: PREDICTING CAROTID ARTERY DISEASE AND PLAQUE VULNERABILITY FROM CELL-DERIVED MICROPARTICLES: THE CAROTID ARTERY BIOMARKER STUDY A Wekesa1, KS Cross2,3, J Dowdall2,3, H Prins3,5, J Phelan1, O O’Donovan1, R Landers2,3, M Doyle2, O O’Brien2, L Byrne4, M Harrison1

1Waterford Institute of Technology, Waterford, Ireland; 2Waterford Regional Hospital, Waterford, Ireland; 3Royal College of Surgeons, Dublin; 4Adelaide and Meath Hospital, Dublin; 5Connolly Hospital, Dublin

14.14O87: SORAFENIB ATTENUATES THE DEVELOPMENT AND PROGRESSION ANGIOTENSIN-II INDUCED AORTIC ANEURYSM B Vijaynagar, N Sylvius, MJ Bown, RD Sayers, E Choke Department of Cardiovascular Sciences, University of Leicester, Leicester

14.21O88: OPERATOR-CONTROLLED IMAGING SIGNIFICANTLY REDUCES RADIATION EXPOSURE DURING ENDOVASCULAR ANEURYSM REPAIR G Peach, S Sinha, SA Black, RA Morgan, IM Loftus, MM Thompson, RJ Hinchliffe St George’s Vascular Institute

14.28O89: THE PREVALENCE AND IMPACT OF ANTIPLATELET RESISTANCE IN CAROTID ARTERY DISEASE R Taylor, K Kanesalingam, A Schiro, C McCollum | The University Hospital of South Manchester

14.35O90: DOSE-DEPENDENT ARTEFACT IN THE FAR WALL OF THE CAROTID ARTERY WITH DYNAMIC CONTRAST ENHANCED ULTRASOUND A Thapar1, J Shalhoub1, M Averkiou2, C Mannaris2, A Davies1, E Leen1

1Imperial College London; 2University of Cyprus

14.42O91: PREDICTING AORTIC COMPLICATIONS AFTER ENDOVASCULAR ANEURYSM REPAIR: DEVELOPMENT AND EXTERNAL VALIDATION OF A MORPHOLOGICAL RISK SCORE A Karthikesalingam1, E Choke2, BO Patterson1, PH Holt1, RJ Hinchliffe1, MU Bown2, RD Sayers2, MM Thompson1

1St George’s Vascular Institute; 2Leicester Royal Infirmary

14.49O92: NEXT GENERATION CORONARY STENT INCORPORATING NANOTECHNOLOGY A Tan1, Y Rafiei1, A de Me l1, J Rajadas2, MS Alavijeh3, AM Seifalian1,4

1University College London; 2Stanford University; 3Pharmidex Pharmaceutical Services; 4Royal Free London NHS Foundation Trust

16

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DAY SUS, SRS(SA) AND ESSR PRIZE WINNERS’

PRESENTATIONGuy Whittle Auditorium | Chairs: Professor Alun Davies andProfessor Dileep Lobo15.00SUS Award WinnerIn Vivo Directed Differentiation of Pluripotent Stem Cells to Bone Lineage and Repair of a Skeletal DefectJS Hyun, M LonglakerStanford University

15.10ESSR Walter Brendel Award WinnerSevoflurane prevents liver inflammatory response induced by lung ischaemia/reperfusion in a lung autotransplant modelL Rancan, L Huerta, G Cusatti, I Erquicia, J Isea, V Garcia, I Garutti, C Simon, E VaraFaculty of Medicine, Complutense University of Madrid

15.20SRS (SA) 2012Do small bowel serosal tears perforate due to raised intraluminal pressure and ishaemia?M Tsai, A Greive, G Candy, M BrandDepartment of Surgery, University of Witwatersrand, Johannesburg, South Africa

TRAUMA AND ORTHOPAEDICSParallel Oral Presentations 2C | Max Rayne AuditoriumChairs: Professor Karim Brohi and Dr Sarah Watts

14.00O93: THE DOSE-DEPENDENT RESPONSE OF VASCULAR ENDOTHELIUM TO BLAST INJURY E Davies1,2, A Spear1, E Kirkman1, C Taylor1, M Midwinter2, S Watts1

1DSTL, Porton Down, Salisbury, Wilts; 2ADMST, RCDM, Birmingham

14.07O94: THE ADMISSION DIFFERENTIAL WHITE CELL COUNT IN TRAUMA – RELATIONSHIP WITH SHOCK, INJURY SEVERITY AND OUTCOME P Vulliamy, J Manson, K BrohiTrauma Clinical Academic Unit, The Royal London Hospital

14.14O95: THE INCIDENCE OF CALCIFIED ATHEROSCLEROSIS AND ASSOCIATION WITH IN-HOSPITAL MORTALITY IN TRAUMA K Oakland, H De’Ath, K Brohi Royal London Hospital, Barts Health NHS Trust

14.21O96: MENISCAL REPAIR SURGERY; SIGNIFICANCE OF EARLY AND SIMULTANEOUS ACL RECONSTRUCTION ON HEALING OF MENISCAL REPAIR H Majeed, KV Sigamoney, SV Karuppiah, G Geutjens, R Straw Royal Derby Hospital

14.28O97: WHEN SHEEP PLAY TENNIS Z Ahmad, R Brooks, F Henson, J Wardale, M Abdus-Samee, A Noorani, G Tytherleigh-Strong, N RushtonUniversity of Cambridge

14.35O98: UNILATERAL LOWER LIMB LOSS FOLLOWING COMBAT INJURY – MEDIUM-TERM OUTCOMES IN BRITISH MILITARY AMPUTEES PM Bennett1, ID Sargeant1, M Midwinter1,3, JG Penn-Barwell1,2,3

1Academic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, Birmingham; 2Institute of Naval Medicine, Gosport; 3National Institute for Health Research (NIHR), Surgical Reconstruction and Microbiology Research Centre (SRMRC), Birmingham

14.42O99: A 100 YEAR REVIEW OF BLOOD USE IN CIVILIAN MASS CASUALTY EVENTS – HOW BEST TO PREDICT FUTURE NEEDS SM Glasgow, ZB Perkins, R Davenport, NRM Tai, K Brohi Department of Trauma Sciences, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London

14.49O100: IDENTIFYING AND ADDRESSING PREVENTABLE PROCESS ERRORS IN TRAUMA PH Pucher , R Aggarwal, A Twaij, N Batrick, M Jenkins, A Darzi Imperial College London

17

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DAYTRANSPLANTATION

Parallel Oral Presentations 3A | Wimpole Lecture Theatre | Chairs: Mr Raj Prasad and Professor Derek Manas

16.00O101: THE UTILITY OF TIME-ZERO BIOPSY SCORING OF ISCHAEMIA/REPERFUSION INJURY AFTER LIVER TRANSPLANTATION J Ali, S Harper, S Mir, J Klink, A Bradley, G PettigrewUniversity of Cambridge

16.07O102: THE FIRST CLINICAL SERIES OF EX-VIVO NORMOTHERMIC PERFUSION (EVNP) IN MARGINAL DONOR KIDNEY TRANSPLANTATION SA Hosgood, C Crotty, ML NicholsonUniversity of Leicester

16.14O103: HOW HELPFUL ARE SERUM MARKERS IN EVALUATING GRAFT PANCREATITIS FOLLOWING SIMULTANEOUS PANCREAS KIDNEY TRANSPLANTATION? M Chhabra, F Powell , N Hilliard, J Bradley , C Watson, A Shaw, S Harper, G Pettigrew University of Cambridge

16.21O104: SIGNIFICANT RESPONSE TO LOCAL ABLATIVE BRIDGING TREATMENTS FACILITATES ACCEPTABLE RATES OF SURVIVAL FOLLOWING LIVER TRANSPLANTATION FOR HCC R Lochan1,3, A Vallance1,3, JJ French1,3, BC Jaques1,3, HL Reeves2, 3, RM Charnley1, SA White1,3 DM Manas1,3

1Department of HPB Surgery; 2Hepatology; and 3Transplantation, Freeman Hospital

16.28O105: WHAT ARE THE IMPLICATIONS OF 12-MONTH SURVEILLANCE BIOPSIES FOLLOWING RENAL TRANSPLANTATION? JP Hunter, V Hansrani, R Babla and ML NicholsonTransplant Group, University of Leicester

16.35O106: MICE ON TRIAL: IS XENOGRAFTS USING HUMAN TISSUE A BETTER MODEL OF CANCER THAN XENOGRAFTS FORMED FROM CELL LINES? G Sadadcharam1, M McCourt2, C Ryan3, K O’Connor3, B Bennett3, DG Power4, S O’Reilly4, JH Wang1, HP Redmond1, EJ Andrews1

1Department of Academic Surgery, Cork University Hospital, Ireland; 2Department of Colorectal Surgery, Cork University Hospital, Ireland; 3Department of Histopathology, Cork University Hospital, Ireland; 4Department of Medical Oncology, Cork University Hospital, Ireland

16.42O107: WITHDRAWN

16.49O108: TISSUE ENGINEERING OF THE KIDNEY USING A WHOLE ORGAN DECELLULARISATION APPROACH M He1, A Callanan1,2, C Chiappini1, MM Stevens1

1Imperial College London; 2University of Limerick

16.56O109: THE EFFECTS OF ARTERIAL PRESSURE DURING A PERIOD OF EX-VIVO NORMOTHERMIC PERFUSION IN A PORCINE KIDNEY MODEL M Patel, SA Hosgood, C Hyde, ML NicholsonUniversity of Leicester

17.03O110: TRANSCRIPTOMIC CHANGES IN HUMAN RENAL BIOPSIES FROM LIVING AND CADAVERIC DONORS AT 30 MINUTES AND 3 MONTHS POST-TRANSPLANTATION B Yang1,2, N Sylvius3, J Luo4, C Yang5, C Crotty1, Z Da6, ML Nicholson1

1Transplant Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, University Hospitals of Leicester, United Kingdom; 2Department of Nephrology, Affiliated Hospital of Nantong University, Nantong 226001, PR China; 3University of Leicester, Genetics, Leicester, United Kingdom; 4MRC Toxicology Unit, Genomics Group, Leicester, United Kingdom; 5Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, PR China; 6Department of Rheumatology and Immunology, Affiliated Hospital of Nantong University, Nantong 226001, PR China

17.10O111: SILDENAFIL ENHANCES RENAL BLOOD FLOW BUT DOES NOT PROTECT AGAINST ISCHAEMIA REPERFUSION INJURY IN A MODEL OF DONATION AFTER CIRCULATORY DEATH KIDNEY TRANSPLANTATION LV Randle2, SA Hosgood1, M Patel1, JA Bradley2, CJ Watson2, ML Nicholson1

1University of Leicester; 2University of Cambridge

17.17O112: LHBP IN PRESERVATION SOLUTION AND AUTOLOGOUS BLOOD PERFUSATE PROTECTS ISOLATED ISCHEMIC PORCINE KIDNEYS C Yang3,4, B Yang*1,2, SA Hosgood1, C Hyde1, Patel Meeta1, Y Long5, T Zhu3,4, ML Nicholson1 1Transplant Group, Department of Infection, Immunity and Inflammation, University of Leicester, Leicester General Hospital, University Hospitals of Leicester; 2Department of Nephrology, Affiliated Hospital of Nantong University, Nantong 226001, PR China; 3Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, PR China; 4Shanghai Key Laboratory of Organ Transplantation, Shanghai, PR China; 5Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China

18

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DAY MISCELLANEOUS

Parallel Oral Presentations 3B | Max Rayne Auditorium | Chairs: Professor Rob Sayers and Mr James Catton

16.00O113: METABOLIC CONSEQUENCES FOLLOWING COLECTOMY IN PATIENTS WITH FAMILIAL ADENOMATOUS POLYPOSIS S Mallappa1, M Samarasinghe1, S Gabe1, R Phillips1, S Clark1, M Robertson2

1St Mark’s Hospital, Harrow; 2University of Surrey, Guildford

16.07O114: EFFECT OF LOCAL AND SYSTEMIC GROWTH FACTORS ON THE HUMAN OSTEOBLAST RESPONSE TO LYSOPHOSPHATIDIC ACID AND VITAMIN D3 J Blackburn, J MansellMusculoskeletal Research Unit, Avon Orthopaedic Centre

16.14O115: 3D IN VITRO CANCER MODEL: A TISSUE ENGINEERING APPROACH TO CANCER RESEARCH T Magdeldin1, A Nyga1, M Loizidou1, U Cheema1,2

1UCL Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Sciences, University College London; 2UCL Institute of Orthopaedics and Musculoskeletal Sciences London

16.21O116: WITHDRAWN

16.28O117: DO DISTINCT GENE AND PROTEIN PROFILES OF CYTOKINES EXIST IN SEVERE SEPSIS? J Sarveswaran, N Orsi, M Cummings, S Homer-Vanniasinkam, D BurkeJohn Goligher Colorectal Unit, St James University Hospital

16.35O118: INHIBITION OF COLONIC BASOLATERAL POTASSIUM CHANNELS USING OCTREOTIDE TO REDUCE BACTERIAL TRANSLOCATION AND SEPSIS I Rajput, JPA Lodge, GI SandleUniversity of Leeds

16.42O119: BACTERIAL-PRODUCED POLYAMINES INTERFERE WITH THE COLONIC MUCUS BARRIER AC Rogers, D Collins, HM Mohan, AW Baird, DC WinterConway Institute of Biomolecular & Biomedical Research, University College Dublin

16.49O120: TUMOUR NECROSIS FACTOR ALPHA IN NON-INFLAMMATORY BOWEL DISEASE ENTEROCUTANEOUS FISTULAS PROSPECTIVE STUDY G Rahbour, HO Al-Hassi, AL Hart, MR Ullah, SM Gabe, SC Knight, J Warusavitarne, CJ VaizeySt Mark’s Hospital and Academic Institute

16.56O121: A NOVEL ‘NON-SLIP’ MICRO-STRUCTURED SURFACE FOR ATRAUMATIC SURGICAL MANIPULATIONGW Taylor, A Neville, PR Culmer, R Roshan, J Barrie, DG JayneUniversity of Leeds

17.03O122: VITAMIN C AMELIORATES RENAL INJURY IN A MURINE MODEL OF CONTRAST-INDUCED NEPHROPATHY KE Rollins1, A Noorani1, L Janeckova2, M Griffiths1, MP Baker2, JR Boyle1

1Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, Cambridge; 2Antitope Ltd, Babraham Science Park, Cambridge

17.10O123: IDENTIFICATION OF LINE1 CHIMERIC TRANSCRIPTS IN CANCER USING BIOINFORMATICS APPROACHES Hang Xu1, Aziz Aboobaker2, Jonathan N Lund1, Cristina Tufarelli11School of Graduate Entry Medicine and Health, Royal Derby Hospital, University of Nottingham; 2Department of Zoology, University of Oxford

17.17O124: IN VITRO STUDIES OF THE WNT SIGNALLING PATHWAYS IN FAP DESMOID TUMOURS Bhandari1, P Uysal Onganer2, D Romero2, RK Phillips1, R Kypta2, SK Clark1

1St Mark’s Hospital; 2Institute of Reproductive and Developmental Biology, Imperial College London

19

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DAYPOSTERS OF DISTINCTION

Parallel Oral Presentations 3C | Guy Whittle Auditorium | Chairs: Professor Dion Morton and Professor Alun Davies

16.00P01: COMPUTATIONAL MODELLING OF EMBOLIC TRAVEL TRAJECTORY IN CEREBRAL ARTERIES: INFLUENCE OF MICRO EMBOLIC PARTICLE SIZE AND DENSITY F Dario1,2, Q Long1, S Das1,2, M Pinelli31Brunel Institute for Bioengineering, Brunel University, Uxbridge; 2Department of Vascular Surgery, Hillingdon Hospital NHS Trust, Hillingdon, Middlesex; 3Facoltà di Ingegneria, Università di Ferrara, Ferrara, Italy

16.05P43: ADULT STEM CELLS IN THE HUMAN AND MOUSE SPINAL CORD: WHAT ARE THEIR CHARACTERISTICS AND CAN THEY MIGRATE AND REPLICATE UPON EXPOSURE TO GROWTH FACTORS S Stokes1,2, N Mani1,2, L O’Connor-Read1,2, M Placzek1

1MRC Centre for Developmental and Biomedical Genetics, and 2Sheffield Institute for Translational Neuroscience, University of Sheffield, Sheffield, UK

16.10P10: PRIMARY AND SECONDARY CARE ATTITUDES TO THE MANAGEMENT OF SUPERFICIAL VENOUS THROMBOSIS TRA Lane, K Sritharan, IJ Franklin, AH DaviesAcademic Section of Vascular Surgery, Imperial College, Charing Cross Hospital, London, UK

16.15P55: THE IMPACT OF SCREENING ON CLINICOPATHOLOGICAL DETERMINANTS OF OUTCOME IN COLORECTAL CANCER IN THE WEST OF SCOTLAND Y Grant1, D Mansouri1,2, E Crighton2, D McMillan2

1University of Glasgow; 2Glasgow Royal Infirmary

16.20P23: ASSESSING THE FACTORS CONTRIBUTING TO THE PRESENTATION OF WOMEN WITHIN THE SCREENING AGE TO SYMPTOMATIC BREAST CLINICSW Al Zawad, S Rajendran, T Roche, A Hill; Royal College of Surgeons

16.25P06: 1H-NMR SPECTROSCOPIC IDENTIFICATION OF BIOMARKERS OF ATHEROSCLEROSIS IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE P Abdulhannan1, M Twigg1, N Mughal1, D Russell1, S Homer-Vanniasinkam1, J Fisher2

Leeds Vascular Institute, Leeds General Infirmary, Leeds, UK -2 School of Chemistry, University of Leeds, Leeds, UK1

16.30P57: THE LONDON BANGLADESHI COMMUNITY: A POPULATION PROTECTED AGAINST THE DISEASE OF WESTERN CIVILISATION R Lahiri1, A Abeles2, K Burnand3, W Alazawi1, G Foster1, C Knowles2

1 Department of Hepatology, Centre for Digestive Diseases and 2National Centre for Bowel Research and Surgical Innovation, Centre for Digestive Diseases, Blizard Institute Barts and the London School of Medicine and Dentistry, Queen Mary University of London; 3Department of Paediatric Surgery, Bristol Royal Hospital for Children, Upper Maudlin Street, Bristol

16.35P13: A UK DISPARITY IN THE TREATMENT OF PATIENTS WITH VARICOSE VEINS HAS BEEN IDENTIFIED HM Moore, TRA Lane, IJ Franklin, AH DaviesAcademic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College School of Medicine

16.40P63: WHAT IS THE VALUE OF PRE-OPERATIVE INVESTIGATIONS IN THE OUTCOME OF TEMPORARY SNS FOR MANAGEMENT OF FAECAL INCONTINENCE? M Feretis, S Karandikar, A Carter, MAS ChapmanDepartment of Colorectal Surgery, Heart Of England NHS Foundation Trust, Birmingham, UK

16.45P04: A PRELIMINARY STUDY OF PHOTOPLETHYSMOGRAPHY AND LASER DOPPLER TO IDENTIFY REDUCED PERFUSION: A ROLE IN ACUTE COMPARTMENT SYNDROME? H Shalabi, E Lincoln, C Mann, J Teoh, S Shalabi, J Crowe, B Hayes-Gill, D SharkeySchool of Clinical Sciences, University of Nottingham

16.50P26: RAISING THE STANDARDS OF OUTCOME REPORTING IN RECONSTRUCTIVE BREAST SURGERY – INITIAL RESULTS OF THE BRAVO (BREAST RECONSTRUCTION AND VALID OUTCOMES) STUDY, A MULTICENTRE CONSENSUS PROCESS TO DEVELOP A CORE OUTCOME SET J Ward1, S Potter1, S Cawthorn2, C Holcombe3, R Warr4, S Wilson4, R Tillett4, E Weiler-Mithoff5, Z Winters6, J Barker2, C Oates4, D Harcourt7, S Brookes1, J Blazeby1,6

1Centre for Surgical Research, School of Social and Community Medicine, University of Bristol; 2Breast Cancer Centre, North Bristol NHS Trust; 3Liverpool and Broadgreen NHS Foundation Trust; 4Department of Plastic Surgery, North Bristol NHS Trust; 5Canniesburn Plastic Surgical Unit; 6University Hospitals Bristol NHS Foundation Trust; 7Institute for Appearance Research, University of the West of England

16.55P08: SINGLE VISIT ENDOVENOUS LASER TREATMENT FOR SYMPTOMATIC SAPHENO-FEMORAL INCOMPETENCE HAS BETTER PATIENT OUTCOME ON MID-TERM FOLLOW-UP LS Alder2, MA Rahi11Royal Blackburn Hospital; 2Imperial College London

17.00P29: INCIDENTAL METASTASES TO INTERNAL MAMMARY LYMPH NODES DETECTED DURING MICROVASCULAR ABDOMINAL FREE FLAP BREAST RECONSTRUCTION: A 15-YEAR REVIEW KY Wong, J Yu, V Broecker, P Forouhi, CM MalataCambridge University Hospitals NHS Foundation Trust

17.05P60: CONTEMPORARY MANAGEMENT AND CLASSIFICATION OF HEPATIC LEIOMYOSARCOMAM Hamed1, KJ Roberts1, W Merchant2, JPA Lodge1

1The Liver Unit; 2Histopathology Department; St James’s University Hospital, Leeds.

17.10P02: PATENCY OF ARTERIOVENOUS VASCULAR ACCESS AND MARKERS OF COAGULATION, FIBRINOLYSIS AND ENDOTHELIAL FUNCTION IN PATIENTS UNDERGOING HAEMODIALYSIS: PROSPECTIVE ANALYSIS JA Milburn1, I Ford2, N Mutch2, N Fluck3, J Brittenden2

1Dept of Vascular Surgery, 2Division of Applied Medicine, 3Renal Medicine, University of Aberdeen and Aberdeen Royal Infirmary

20

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DAY

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DAY JOHN FARNDON LECTURE

Guy Whittle Auditorium

ASIT SYMPOSIUMGuy Whittle AuditoriumChairs: Mr Vimal Gokani and Mr Joseph Shalhoub

ANNUAL GENERAL MEETING OF THE SOCIETY OF ACADEMIC AND RESEARCH SURGERY

Guy Whittle Auditorium

Wednesday 17.30Breast Surgery – What is the future?Professor Arnold DK Hill, Professor of Surgery and Chairman of the Department of Surgery at The Royal College of Surgeons in Ireland and at Beaumont Hospital, DublinIntroduced by Mr Frank Smith

Thursday 08.00Debate: A doctorate degree is necessary for progress in the current training systemFor: Professor Cliff ShearmanAgainst: Professor Dion Morton

Wednesday 18.00

Agenda:1. Apologies2. Minutes of the last AGM held on 4 January 20123. Matters arising4. President’s Report5. Honorary Secretary’s Report6. Treasurer’s Report7. Future SARS meetings8. Date of next meeting All members and non-members are encouraged to attend.

21

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RSD

AYMEDICAL STUDENT PRIZEParallel Oral Presentations 4A | Guy Whittle Auditorium | Chairs: Miss Hayley Moore and Professor Dileep Lobo

08.45O25: ELEVATED EXPRESSION OF MIR-106 AND MIR-202 IN BREAST CANCER M McLoughlin, CL Glynn, PS Waters, S Khan, RM Dwyer, MJ KerinDiscipline of Surgery, School of Medicine, National University of Ireland Galway, Galway, Ireland

08.53O26: THE EFFECT OF PROPRANOLOL ON POST-BURN SCAR APPEARANCE: A RANDOMISED, CONTROLLED TRIAL NT Mabvuure1, A El-ayadi2, DN Herndon2, H Hawkins2, CC Finnerty2 1Brighton and Sussex Medical School, Brighton; 2Shriners Hospital for Children, Galveston, TX, USA

09.01O27: WISP-2 REGULATES COLORETCAL CANCER CELL INVASION AND MOTILITY KA Frewer, AJ Sanders, R Hargest, WG JiangMetastasis and Angiogenesis Research Group, Institute of Cancer and Genetics, Cardiff University School of Medicine, Heath Park, Cardiff

09.09O28: FACTOR XIII VAL34LEU POLYMORPHISM AND DIABETES IN ABDOMINAL AORTIC ANEURYSMS HL Evans1,2, KJ Griffin1,3, F Macrae1, MA Bailey1,3, S Sohrabi1, DJA Scott1,3, RAS Ariens1

1DCDR, LIGHT Institute, Leeds; 2University of Leeds, Leeds; 3Leeds Vascular Institute, Leeds General Infirmary, Leeds

09.17O29: INTERLEUKIN-24 AND LYMPHANGIOGENESIS OF HUMAN BREAST CANCER NC Frewer, L Ye, P-H Sun, K Ji, R Hargest, WG Jiang Metastasis and Angiogenesis Research Group, Institute of Cancer and Genetics (Section of Surgery), Cardiff University School of Medicine, Heath Park, Cardiff

09.25O30: IDENTIFICATION OF BIOMOLECULAR MARKER OF CHRONIC LUNG ALLOGRAFT REJECTION I Atugba, C Ward, S AliInstitute of Cellular Medicine, Newcastle University

09.33O31: PROMOTER METHYLATION OF ZINC TRANSPORTER GENES IN THE AGEING HUMAN BOWEL E Kilcourse, J McKay, N Willis, JC MathersInstitute for Ageing and Health, Newcastle University

09.41O32: EFFECTIVE TARGETING OF MEK (MAP KINASE, KINASE) IN BREAST CANCER CELLS G Gan, N Roberts, V Lopez-Davila, M Loizidou, H WelchDivision of Surgery and Interventional Science, UCL Medical School Royal Free Campus

09.49O33: UTILISING A BIOREACTOR TO EVALUATE SMOOTH MUSCLE CELL PHENOTYPE AND FUNCTION IN PROTEASE TREATED PORCINE ARTERY MODEL OF AAA DISEASE GS Mudhar1 , K Riches2, P Walker3, S Sohrabi4, DJA Scott2,4, KE Porter2

1School of Medicine, University of Leeds; 2 Division of Cardiovascular Medicine, Leeds Institute for Genetics, Health and Therapeutics (LIGHT); 3School of Engineering, University of Leeds; 4Department of Vascular Surgery, Leeds General Infirmary

09.57O34: RADIOFREQUENCY TISSUE FUSION FOR SMALL BOWEL SEALING: A STUDY OF SEAL QUALITY USING MECHANICAL TESTING AND IMAGING N Hadjievangelou1, S Arya1, L Su1, H Kudo2, RD Goldin2, AW Darzi1, DS Elson1, GB Hanna1

1Division of Surgery, Department of Surgery and Cancer, Imperial College London, St Mary’s Hospital South Wharf Road, London; 2Centre for Pathology, Department of Cellular Pathology, St Mary’s Hospital, South Wharf Road, London

10.05O35: RELATIONSHIP BETWEEN CIRCULATING MIRNAS AND BREAST CANCER EPITHELIAL SUBTYPE MF Duignan, C Brougham, PS Waters, RM Dwyer, MJ KerinDiscipline of Surgery, School of Medicine, National University of Ireland Galway

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AY MISCELLANEOUS 2Parallel Oral Presentations 4B | Max Rayne Auditorium | Chairs: Mr Daryll Baker and Mr Geoff Candy

08.45O125: VOLUMETRIC MATERIAL LOSS IN METAL-ON-METAL TOTAL HIP ARTHROPLASTY: BEARING SURFACE WEAR VERSUS TAPER CORROSION A Hexter, A Matthies, P Bills, J Skinner, A HartThe London Implant Retrieval Centre, Imperial College London

08.52O126: A PILOT STUDY INVESTIGATING THE INFLUENCE OF VISCERAL OBESITY ON OUTCOMES FOLLOWING ANTERIOR RESECTION COMPLICATED BY ANASTOMOTIC LEAK NA Hirst, S Hafeji, D Tolan, DG JayneSt James’s University Hospital, Leeds

08.59O127: MOUSE TO MAN: MURINE, RODENT, PORCINE AND HUMAN STUDIES OF A PROMISING MITOCHONDRIA-TARGETED THERAPY FOR RENAL ISCHAEMIA REPERFUSION INJURY AJ Dare1,2, A Logan2, I Panagiotopoulou1, EA Bolton1, SA Hosgood3, M Nicholson3, GJ Pettigrew1, JA Bradley1, K Saeb-Parsy1, MP Murphy2

1Department of Surgery, University of Cambridge; 2MRC Mitochondrial Biology Unit; 3University of Leicester

09.06O128: IMAGING GOLD NANOPARTICLES IN A NOVEL TISSUE ENGINEERED 3D IN VITRO CANCER MODELT Magdeldin1, A Nyga1, A Asghari1 H Welch1, M Loizidou1, U Cheema1,2, K Ricketts3, A Gibson3, G Royle3, C Guazzoni4, A Castolidi4, G Montemurro4

1University College London, UCL Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Sciences; 2UCL Institute of Orthopaedics & Musculoskeletal Science, London; 3Department of Medical Physics and Bioengineering, UCL, London; 4Dipartimento di Elettronica e Informazione, Politecnico di Milano, Italy, Sezione di Milano, Italy

09.13O129: THE INFLUENCE OF MDM2 AND MDMX PROTEINS ON P53 EXPRESSION IN HUMAN LIPOSARCOMAS INVITES CAREFUL EVALUATION OF NOVEL TARGETED THERAPIES N Touqan1,2, I Carr1, R Anwar1, AF Markham1, W Merchant2, R Achuthan2, K Horgan2

1University of Leeds School of Medicine; 2Leeds Teaching Hospitals NHS Trust

09.20O130: M-THPC DELIVERY VIA PEGYLATED PLGA NANOPARTICLES FOR IN VIVO PHOTODYNAMIC THERAPY (PDT)MJ Bovis, JH Woodhams, M Rojnik, P Kocbek, J Kos, SG Bown, AJ MacRobert, M LoizidouUniversity College London

09.27O131: THE DEVELOPMENT OF RESORBABLE NANOCOMPOSITE TRACHEA AND BRONCHI SCAFFOLDS FOR PAEDIATRIC APPLICATIONS: A TISSUE ENGINEERING SOLUTION TO ORGAN TRANSPLANTATIONGZ.Teoh1, C Crowley1,2, M Birchall1,2, AM Seifalian1

1University College London, UCL Centre for Nanotechnology and Regenerative Medicine, Division of Surgery and Interventional Sciences, and 2UCL Ear Institute, Royal National Throat, Nose & Ear Hospital, London, UK

09.34O132: IMPACT OF NON-DIGESTIBLE CARBOHYDRATE ON METHYLATION OF GADD45A PROMOTER IN THE HUMAN COLON C Jones, N Willis, I McCallum, JC MathersInstitute of Ageing and Health

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AYRSM SECTION OF SURGERY MIA PRIZEGuy Whittle Auditorium | Chairs: Mr Frank Smith and Mr Hamid Khawaja

10.45O15: FOXO3A EXPRESSION IN COLORECTAL CANCER: A PROMISING BIOMARKER OF MICROMETASTASES A Bruce, M Bullock, N Curtis, R Sreekumar, J Primrose, G Thomas, AH Mirnezami University of Southampton Cancer Research UK Centre

10.54O16: EVALUATION OF THE ACUTE INFLAMMATORY RESPONSE TO OMEGA-3 FATTY ACIDS IN PATIENTS WITH SEVERE ACUTE PANCREATITIS: A RANDOMISED CONTROLLED TRIAL D Al-Leswas, W-Y Chung, A Eltweri, A Arshad, C Pollard, M Metcalfe, A DennisonHepatobiliary and Pancreatic Surgery, University Hospitals of Leicester, Leicester

11.03O17: GENOME ANALYSIS OF COLORECTAL CANCERS IN BRITISH BANGLADESHIS IDENTIFIES EARLY ONSET AND A HIGH PREVALENCE OF RBFOX1 DELETION COMPARED TO CAUCASIANS N Sengupta1, C Yau2, J-B Cazier4, Sina Dorudi1, O Sieber3,5, A Silver1, C Lai11Centre for Digestive Diseases, Blizard Institute of Cell and Molecular Science, Barts and The London School of Medicine and Dentistry, Queen Mary University of London; 2Department of Mathematics, South Kensington Campus, Imperial College London; 3Ludwig Colon Cancer Initiative Laboratory, Ludwig Institute for Cancer Research, Parkville, Australia; 4Bioinformatics and Statistical Genetics; 5Faculty of Medicine, Dentistry and Health Sciences, Department of Surgery, University of Melbourne, Parkville, Australia

11.12O18: EVALUATION OF ONE STEP NUCLEIC ACID AMPLIFICATION (OSNA) MOLECULAR ASSAY FOR INTRA-OPERATIVE DIAGNOSIS OF SENTINEL LYMPH NODE METASTASIS S Banerjee, N Michalopoulos, N Williams, T Davidson, S El Seik, N McDermott, M Tran-Dang, S Davison, M KeshtgarRoyal Free London NHS Foundation Trust

11.21O19: RESPONSE OF COLORECTAL CANCER CELLS TO DIFFERENT MEK INHIBITORS V López-Dávila, H Welch, M LoizidouDivision of Surgery and Interventional Sciences, University College London

11.30O20: MYELOID CELLS ARE RECRUITED BY LIVER METASTASES AND AID THEIR DEVELOPMENT AN Gordon-Weeks, L Zhao, SY Lim, Y Cao, J Beech, D Allen, S Smart, RJ Muschel Gray Institute for Radiation Oncology and Biology, University of Oxford

11.39O21: METHYLATION OF THE NOTCH PATHWAY IN PATIENTS AT HIGHER RISK OF COLORECTAL CANCER AND EFFECTS OF SUPPLENTATION WITH RESISTANT STARCH IN A RANDOMISED CONTROLLED TRIAL IJD McCallum1,2, SB Kelly1, M Bradburn1, N Willis2, L Xie2, JC Mathers2

1North Tyneside Hospital, North Shields, UK; 2Human Nutrition Research Centre, Institute for Ageing and Health, Newcastle University, Newcastle upon Tyne

11.48O22: PROGRESSIVE ALTERATIONS IN CD4+ T CELL PHENOTYPES IN BREAST CANCER PATIENTS FOLLOWING CHEMOTHERAPY R Verma1,3, NL Smalle2, RE McCurtin2, K Horgan1, TA Hughes3, CRD Carter2

1Department of Surgery, Leeds General Infirmary, Leeds; 2Department of Immunology and Transplant Immunology, St James’s University Hospital, Leeds; 3Leeds Institute of Molecular Medicine, University of Leeds

11.57O23: LONG-TERM FOLLOW-UP OF THE MRC CONVENTIONAL VERSUS LAPAROSCOPICALLY ASSISTED RESECTION IN COLORECTAL CANCER TRIAL BL Green1, HC Marshall1, F Collinson1, DG Jayne2, JM Brown1

1Clinical Trials Research Unit, University of Leeds, Leeds, UK; 2Section of Translational Anaesthesia and Surgery, Leeds Institute of Molecular Medicine, St James’s University Hospital, Leeds

12.06O24: GLOBAL ANALYSIS OF THE SRC-1 AND HOXC11 TRANSCRIPTOMES IDENTIFIES A NOVEL ROLE FOR SRC-1 AND HOXC11 IN SUPPRESSING LUMINAL A MARKERS IN BREAST CANCERJC Bolger1, CA Walsh1, DP McCartan1, A Cahalin1, Y Hao2, J Xu2, P O’Gaora2, AD Hill1, LS Young1

1Endocrine Oncology Research, Royal College of Surgeons in Ireland, Dublin; 2School of Medicine, Conway Institute, University College Dublin

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AY VASCULAR SURGERY 2Parallel Oral Presentations 5A | Guy Whittle Auditorium | Chairs: Mr Mike Wyatt and Mr Domenico Valenti

12.15O133: MICROEMBOLI IDENTIFIED IN THE RIGHT HEART DURING THERMOABLATION OF VARICOSE VEINS V Sounderajah, HM Moore, A Thapar, TRA Lane , KF Fox, IJ Franklin, AH DaviesAcademic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College School of Medicine

12.22O134: COMPARISON OF THE EFFECT OF OPEN AND ENDOVASCULAR (EVAR) ANEURYSM REPAIR ON RENAL FUNCTION A Saratzis1, P Sarafidis2,3, D Christopoulos2, D Kiskinis2,GD Kitas1

1Department of Research and Development, Dudley Group NHS Foundation Trust, Russells Hall Hospital, Dudley, West Midlands, UK; 2Department of Vascular Surgery, Aristotle University of Thessaloniki, Greece; 3Department of Renal Medicine, King’s College, London

12.29O135: IS THERE A ROLE FOR C-REACTIVE PROTEIN, MYELOPEROXIDASE OR BETA-2-MICROGLOBULIN AS A MARKER OF CAROTID PLAQUE INSTABILITY? RK Birk1, MK Salem1, K West2, D Moore2, A Nicolaides3, RD Sayers1, AR Naylor1, MJ Bown1

1Vascular Surgery Group, Department of Cardiovascular Sciences, Robert Kilpatrick Clinical Sciences Building, University of Leicester; 2Department of Histopathology, University Hospitals Leicester; 3Department of Vascular Surgery, Imperial College, London

12.36O136: HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND ABDOMINAL AORTIC ANEURYSM – A MENDELIAN RANDOMISATION STUDY SC Harrison1, MV Holmes1, FW Asselbergs on behalf of the SMART study2, MJ Bown on behalf of the Aneurysm Consortium3, AF Baas on behalf of the Utrecht Study2, S Grettarsdottir on behalf of the Iceland Study4, GT Jones on behalf of the New Zealand Study5, SE Humphries1

1University College London; 2Utrecht Medical Centre; 3Leicester University; 4Decode Genetics, Iceland; 5Otago University

12.43O137: THE ASSOCIATION BETWEEN ENDOTHELIAL NITRIC OXIDE SYNTHASE (ENOS) AND METHYLENE TETRAHYDROFOLATE REDUCTASE (MTHFR) POLYMORPHISMS AND ABDOMINAL AORTIC ANEURYSM (AAA) A Saratzis1, MJ Bown2, JB Wild2, RD Sayers2, JP Smith1, GD Kitas1

1Department of Research and Development, Dudley Group NHS Foundation Trust, Russells Hall Hospital, Dudley, West Midlands; 2Department of Cardiovascular Sciences, University of Leicester

12.50O138: A NOVEL CYTOSOLIC PROTEIN COMPLEX REGULATES LOX-1 SCAVENGER RECEPTOR-MEDIATED ENDOCYTOSIS OF PROATHEROGENIC OXIDISED LOW-DENSITY LIPOPROTEIN PARTICLES NA Mughal1,2, K Freestone2, Z Holloway3, AP Monaco3, DA Russell1, S Homer-Vanniasinkam1,2, S Ponnambalam2

1Leeds Vascular Institute, The General Infirmary at Leeds, Leeds; 2Endothelial Cell Biology Unit, Leeds Institute of Genetics, Health and Therapeutics, University of Leeds; 3Wellcome Trust Centre for Human Genetics, University of Oxford

12.57O139: VEIN DIAMETER IS ASSOCIATED WITH DISEASE SEVERITY NOT QUALITY OF LIFE IMPAIRMENT TRA Lane, AC Shepherd, MS Gohel, IJ Franklin, AH DaviesAcademic Section of Vascular Surgery, Imperial College London, Charing Cross Hospital, London

13.04O140: THE SHORTFALL IN SURVIVAL OF PATIENTS WITH REPAIRED THORACIC OR ABDOMINAL AORTIC ANEURYSMS A Karthikesalingam, BO Patterson, G Peach, JD Poloniecki, A Vidal-Diez, PJ Holt, RJ Hinchliffe, MM Thompson St George’s Vascular Institute

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AYUPPER GIParallel Oral Presentations 5B | Max Rayne Auditorium | Chairs: Mr Adrian Steyer and Professor Derek Alderson

12.15O141: LONG TERM SURVIVAL FOLLOWING GASTRECTOMY FOR CANCER IN RANDOMISED CONTROLLED ONCOLOGICAL TRIALS: COMPARISON BETWEEN WEST AND EAST SR Markar1, A Karthikesalingam2, D Jackson3, G Hanna1

1Department of Surgery and Cancer, St Mary’s Hospital, Imperial College, London, UK; 2Department of Outcome Research, St George’s Vascular Institute, St George’s Hospital, London, UK; 3MRC Biostatistic Unit, Cambridge

12.22O142: TOWARDS MOLECULAR ASSESSMENT OF SURGICAL METABOLIC RESPONSE: EXHALED BREATH SIGNATURES OF MAJOR UPPER GASTROINTESTINAL SURGERY PR Boshier, V Mistry, JR Cushnir, OM Kon, SL Elkin, S Curtis, N Marczin, GB HannaImperial College London

12.29O143: A REVIEW OF THE PREVALANCE AND IMPACT OF ANAEMIA DURING NEOADJUVANT THERAPY FOR UPPER GASTROINTESTINAL ADENOCARCINOMABD Keeler, JA Simpson, MJ Brookes, A Reece-Smith, S Madhusudan, S Parsons, J Catton, AG Acheson Nottingham University Hospitals NHS Trust

12.36O144: HEALTH-RELATED QUALITY OF LIFE REPORTING IN BARIATRIC SURGERY: A SYSTEMATIC REVIEW OF CURRENT PRACTICE T Abdelrahman1,2, K Coulman1,3, A Owen-Smith1, RC Andrews 4,5, R Welbourn3, JM Blazeby1,6

1School of Social and Community Medicine, University of Bristol, Canynge Hall, Bristol; 2Department of Upper GI Surgery, West Wales General Hospital, Hywel Dda Health Board, Carmarthen, Wales; 3Department of Bariatric and Upper GI Surgery, Musgrove Park Hospital, Taunton; 4 School of Clinical Sciences, University of Bristol, Southmead Hospital, Bristol; 5Department of Diabetes and Endocrinology, Musgrove Park Hospital, Taunton; 6Division of Surgery, Head & Neck, University Hospitals Bristol NHS Foundation Trust, Bristol Royal Infirmary

12.43O145: OBESITY AND RADIOSENSITIVITY STATUS INFLUENCE GENOMIC INSTABILITY EVENTS: ANAPHASE BRIDGE FORMATION AND SPINDLE ASSEMBLY CHECKPOINT GENE EXPRESSION IN OESOPHAGEAL CANCER AM Mongan, N Lynam-Lennon, L Marignol, S Maher, G Pidgeon, JN O’Sullivan JV ReynoldsUniversity Department of Surgery, Trinity Healthcare Sciences Building, St James’s Hospital and Trinity College, Dublin

12.50O146: PRE-TREATMENT FDG-PET DOES NOT PREDICT OUTCOME IN RESECTABLE OESOPHAGEAL CANCER PATIENTS A Pillai, AR Davies, H Sandhu, P Sinha, S Helme, L Ramage, J Deguara, JA Gossage, AJ Botha, RC MasonDepartment of Surgery, St Thomas’ Hospital, London

12.57O147: IRON CHELATORS AS CHEMOTHERAPY ADJUNCTS IN OESOPAHAGEAL ADENOCARCINOMA: IN-VITRO AND IN-VIVO EFFECTS OF DEFERASIROX MR Bedford1, SJ Ford1, O Tucker2, T Iqbal1, D Alderson2, C Tselepis1

1School of Cancer Sciences, University of Birmingham; 2Department of Academic Surgery, University Hospitals Birmingham NHS Foundation Trust

13.04O148: IMPROVING THE STANDARD OF LYMPH NODE RETRIEVAL AFTER GASTRIC CANCER SURGERY I Amygdalos, PR Boshier, M Ni, S Mikhail, J Lloyd, R Goldin, GB HannaImperial College London

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AY PATEY PRIZE 2Guy Whittle Auditorium | Chairs: Professor Andrew Bradley and Professor Rob Pickard

14.00O8: TARGETING PANCREATIC CANCER STROMA BY HDAC INHIBITORS MA Ghallab, G Rosignoli, IS Escrig, HC Hurst, IR Hart, S Bhattacharya, HM KocherBarts Cancer Institute, Queen Mary University

14.10O9: SIFT-MS ANALYSIS OF HEADSPACE VAPOUR FROM GASTRIC CONTENT FOR THE DIAGNOSIS OF GASTRO-OESOPHAGEAL CANCER S Kumar, J Huang, GB HannaDivision of Surgery and Cancer, Imperial College London

14.20O10: REDUCED EXPRESSION OF SEMAPHORIN (SEMA4D) AND PLEXIN B IN BREAST CANCER IS ASSOCIATED WITH POORER PROGNOSIS, AND THE POTENTIAL LINKAGE WITH OESTROGEN RECEPTOR FA Malik1,2, L Ye1, WG Jiang1

1Metastasis and Angiogenesis Research Group, Cardiff University School of Medicine, Cardiff; 2Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan

14.30O11: GLOBAL GENETIC ALTERATIONS FROM PRIMARY AND NODE TO METASTASIS: NEW INSIGHTS INTO BREAST TUMOUR REPROGRAMMINGJC Bolger1, DP McCartan1, A Fagan1, E Hughes1, J McBryan1, P O’Gaora2, AD Hill1, LS Young1

1Endocrine Oncology Research; 2Royal College of Surgeons in Ireland, Dublin

14.40O12: ACTIVATION OF HIF1α PROMOTES ANDROGEN LINDEPENDENT PROSTATE CANCER CELL GROWTHGB Tran, F Lo, A Ramos-Mantoya, S Menon, M Osborne, J Hadfield, A Warren, C Massie, P Maxwell, I Mills, D NealAddenbrooke’s/Cambridge University, lab 120 Uro-oncology Group

14.50O13: THERAPEUTIC FATTY ACID SYNTHASE INHIBITION CAN BE MONITORED USING 11C ACETATE PET IN A XENOGRAFT MODEL OF PROSTATE CANCERGL Shaw, D Lewis, J Boren, A Ramos-Montoya, D Soloviev, K Brindle, D Neal Cambridge University

15.10O14: DESIGN OF NOVEL NANOCOMPOSITE NERVE CONDUITST Sedaghati1, G Jell1, A Mosahebi1,2, P Butler1,2, AM Seifalian1

1Centre for Nanotechnology and Regenerative Medicine, UCL Division of Surgery and Interventional Sciences, University College London, London; 2Department of Plastic and Reconstructive Surgery, Royal Free Hampstead NHS Trust Hospital, London

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AYZACHARY COPE LECTUREGuy Whittle Auditorium

BJS LECTUREGuy Whittle Auditorium

PRESENTATION OF PRIZESGuy Whittle AuditoriumChair: Professor Andrew Bradley and Mr Frank Smith

15.30The androgen receptor and prostate cancerProfessor David NealProfessor of Surgical OncologyAddenbrooke’s Hospital, CambridgeChair: Professor Derek Alderson

16.00Attempts to innovate in coloproctology and beyondProfessor Norman WilliamsPresident, The Royal College of Surgeons of EnglandWe gratefully acknowledge the support of the BJS for this lecture.Introduced by Professor Andrew Bradley

16.30–16.50

DATE FOR YOUR DIARY

The next SARS meeting is to be held at Robinson College, University of Cambridge

8 and 9 January 2014

We look forward to seeing you there!

Local organiser: Professor Cliff ShearmanSponsorship and other enquiries to: SARS SecretariatTel: 020 7869 6640Email: sars@rcseng.ac.uk

Up to date details will be on the SARS website www.surgicalresearch.org.uk

28 ANNuAl meetiNg 2013

SARS POSTER PRESENTATIONS – DISPLAYED IN THE EDR/CLUB FOYER/ENT ROOM

P01: COMPUTATIONAL MODELLING OF EMBOLIC TRAVEL TRAJECTORY IN CEREBRAL ARTERIES: INFLUENCE OF MICRO EMBOLIC PARTICLE SIZE AND DENSITY F Dario1,3, Q Long1, S Das1,2, MPinelli31Brunel Institute for Bioengineering, Brunel University, Uxbridge; 2Department of Vascular Surgery, Hillingdon Hospital NHS Trust, Hillingdon, Middlesex, UK; 3Facoltà di Ingegneria, Università di Ferrara, Ferrara, ItalyP02: PATENCY OF ARTERIOVENOUS VASCULAR ACCESS AND MARKERS OF COAGULATION, FIBRINOLYSIS AND ENDOTHELIAL FUNCTION IN PATIENTS UNDERGOING HAEMODIALYSIS: PROSPECTIVE ANALYSIS JA Milburn1, I Ford2, N Much2, N Fluck3, J Brittenden2

1Dept of Vascular Surgery, 2Division of Applied Medicine, 3Renal Medicine, University of Aberdeen and Aberdeen Royal Infirmary, ScotlandP03: THE IMMEDIATE IMPACT OF EXERCISE TRAINING ON INFLAMMATORY MARKERS AND ENDOTHELIAL FUNCTION IN PATIENTS WITH INTERMITTENT CLAUDICATION R Gohil,L Madden, IC Chetter Hull York Medical School, Hull University, Hull and East Yorkshire Hospitals Trust P04: A PRELIMINARY STUDY OF PHOTOPLETHYSMOGRAPHY AND LASER DOPPLER TO IDENTIFY REDUCED PERFUSION: A ROLE IN ACUTE COMPARTMENT SYNDROME? H Shalabi, E Lincoln, C Mann, J Teoh, S Shalabi, J Crowe, B Hayes-Gill, D SharkeySchool of Clinical Sciences, University of Nottingham P05: THE UTILISATION OF THE MUST NUTRITIONAL SCREENING TOOL ON VASCULAR SURGICAL WARDS NTewari1,2, J Rodrigues3, NAltaf3, SAwad1,2

1Division of Gastrointestinal Surgery, University of Nottingham; NIHR Nottingham Digestive Diseases Centre Biomedical Research Unit; 3Nottingham University Hospitals NHS TrustP06: 1H-NMR SPECTROSCOPIC IDENTIFICATION OF BIOMARKERS OF ATHEROSCLEROSIS IN PATIENTS WITH PERIPHERAL ARTERIAL DISEASE P Abdulhannan1, M Twigg1, N Mughal1, D Russell1, S Homer-Vanniasinkam1, J Fisher2

1Leeds Vascular Institute, Leeds General Infirmary, Leeds, UK; 2School of Chemistry, University of Leeds, LeedsP07: HYDROGEN SULPHIDE TREATMENT REDUCES THE EFFECTS OF REMOTE RENAL ISCHAEMIA-REPERFUSION INJURY IN A MODEL OF AORTIC CROSS CLAMPING JP Hunter, SA Hosgood, M Patel, C Hyde, RD Sayers, ML NicholsonUniversity of Leicester P08: SINGLE VISIT ENDOVENOUS LASER TREATMENT FOR SYMPTOMATIC SAPHENO-FEMORAL INCOMPETENCE HAS BETTER PATIENT OUTCOME ON MID-TERM FOLLOW-UP LS Alder2, MA Rahi11Royal Blackburn Hospital; 2Imperial College LondonP09: IMPAIRED PREOPERATIVE RENAL FUNCTION IS ASSOCIATED WITH DECREASED SURVIVAL AFTER ENDOVASCULAR ABDOMINAL AORTIC ANEURYSM REPAIR A Saratzis1, P Sarafidis2, D Kiskinis2, K Ktenidis2, D Christopoulos2, GD Kitas1

1Department of Research and Development, Dudley Group NHS Foundation Trust, Russells Hall Hospital, Dudley, West Midlands, UK; 2Department of Vascular Surgery, Aristotle University of Thessaloniki, Thessaloniki, GreeceP10: PRIMARY AND SECONDARY CARE ATTITUDES TO THE MANAGEMENT OF SUPERFICIAL VENOUS THROMBOSIS TRA Lane, K Sritharan, IJ Franklin, AH DaviesAcademic Section of Vascular Surgery, Imperial College, Charing Cross Hospital, London

P11: A SYSTEMATIC REVIEW AND META-ANALYSIS OF PROGNOSTIC VARIABLES FOR SECONDARY AMPUTATION FOLLOWING SURGICAL REPAIR OF LOWER EXTREMITY VASCULAR TRAUMAZB Perkins1, S Glasgow1, K Brohi1, NRM Tai1, 2

1Trauma Sciences, Barts and the London School of Medicine and Dentistry, Queen Mary, University of London, London, UK; 2Academic Department of Military Surgery and Trauma, Royal Centre for Defence Medicine, UKP12: AN ANALYSIS OF RUPTURE POST EVAR – EXPERIENCE FROM A SINGLE UNIT J McCaslin, L Wilson, M Clarke, R Williams, M WyattFreeman Hospital, NewcastleP13: A UK DISPARITY IN THE TREATMENT OF PATIENTS WITH VARICOSE VEINS HAS BEEN IDENTIFIED HM Moore, TRA Lane, IJ Franklin, AH DaviesAcademic Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College School of Medicine P14: ENDOVASCULAR ANEURYSM REPAIR INCREASES AORTIC STIFFNESS VJ Gokani, B Williams, MJ Bown, RD Sayers University of Leicester P15: HINDFOOT FUSION IN HAEMOPHILIAC ARTHROPATHYM Brklijac, A Yvon, S Shah, C HayManchester Royal Infirmary P16: DEMENTIA AND HIP FRACTURE: HOW CAN ADAPTING ACUTE MANAGEMENT IMPROVE OUTCOME?CL Connelly, The University of Edinburgh P17: REDUCING THE THERMAL EFFECTS OF DRILLING IN BONE: A NOVEL DRILL DESIGNWKM Kieffer, JR GibbsBrighton and Sussex University Hospitals P18: IGF-1 HAS NO EFFECT ON THE PROLIFERATION AND DIFFERENTIATION OF ISCHAEMIC MYOBLASTSN Oikonomopoulos, M Fincher1, D Abraham2, D Baker1, Tsui J1

1Division of Surgery and Interventional Science, UCL, Royal Free Campus, UK; 2Centre for Rheumatology and Connective Tissue Disease, UCL, Royal Free CampusP19: COST AND CLINICAL IMPLICATIONS OF PERFORMING BLOOD TYPE AND SCREEN TESTING PRIOR TO ELECTIVE ORTHOPAEDIC PROCEDURES: A WASTE OF VALUABLE RESOURCES? J Ha1, G Phoenix2, A Williams2

1West Middlesex University Hospital; 2Chelsea and Westminster Hospital P20: RECONSTRUCTION IN SEVERE PELVIC BONE LOSS AND DISCONTINUITY; USING A CONED HEMI-PELVIS WITH A POSTERIOR APPROACH TO THE HIPMK Quraishi1, H Sadique1, S Evans2, LJeys2, R Grimer2

1College of Medical and Dental Sciences, University of Birmingham; 2Royal Orthopaedic Hospital NHSFT, BirminghamP21: AAA: PLASMA PROTEIN BIOMARKERS AND MECHANISTIC PATHWAYS S Ehsan1, S Slade2, D Boocock3, K Herbert1, RD Sayers1, MJ Bown1

1 University of Leicester; 2University of Warwick; 3Nottingham Trent University P22: DIFFERENT LEVELS OF CROSS-LINKING FOR TENDON AUGMENTATION MATERIALSZ Ahmad, R Brooks, F Henson, J Wardale, MAbdus-Samee, N RushtonUniversity of Cambridge P23: ASSESSING THE FACTORS CONTRIBUTING TO THE PRESENTATION OF WOMEN WITHIN THE SCREENING AGE TO SYMPTOMATIC BREAST CLINICSW Al Zawad, S Rajendran, T Roche, A Hill Royal College of Surgeons

29ANNuAl meetiNg 2013

P24: NOVEL CIRCULATING MICRORNA BIOMARKERS FOR LUMINAL A BREAST CANCERLM Martyn, AM McDermott, G Ball, N Miller, MJ KerinDiscipline of Surgery, National University Ireland, Galway P25: THE ROLE OF SENTINEL NODE BIOPSY IN THE MANAGEMENT OF BREAST CANCERNR Hope, B McAlary, C Jones, H Mathers, JM Bingham Altnagelvin Area HospitalP26: RAISING THE STANDARDS OF OUTCOME REPORTING IN RECONSTRUCTIVE BREAST SURGERY – INITIAL RESULTS OF THE BRAVO (BREAST RECONSTRUCTION AND VALID OUTCOMES) STUDY, A MULTICENTRE CONSENSUS PROCESS TO DEVELOP A CORE OUTCOME SETJ Ward1, S Potter1, S Cawthorn2, C Holcombe3, R Warr4, S Wilson4, R Tillett4, E Weiler-Mithoff5, Z Winters6, J Barker2, C Oates4, D Harcourt7, S Brookes1, J Blazeby1,6

1Centre for Surgical Research, School of Social and Community Medicine, University of Bristol; 2Breast Cancer Centre, North Bristol NHS Trust; 3Liverpool and Broadgreen NHS Foundation Trust; 4Department of Plastic Surgery, North Bristol NHS Trust; 5Canniesburn Plastic Surgical Unit; 6University Hospitals Bristol NHS Foundation Trust; 7Institute for Appearance Research, University of the West of EnglandP27: FINDING GRANULOMATOUS MASTITIS IN THE MIDDLE EAST; PRESENTATION, TREATMENT AND OUTCOMES SEEN IN A UAE BREAST CENTREMK Quraishi1, H Badsha2, H Kazim3

1College of Medical and Dental Sciences, University of Birmingham; 2Deptartment of Rheumatology, Dr. Humeira Badsha Medical Center, UAE; 3Dept of Breast Surgery, Well Woman Clinic, Dubai, UAEP28: PERSISTENT SEROMAS IN ABDOMINAL FREE FLAP DONOR SITES AFTER POST-MASTECTOMY BREAST RECONSTRUCTION SURGERYAM MSadeghi1, CM Malata2

1University of Cambridge, School of Clinical Medicine; 2Department of Plastic and Reconstructive Surgery, Cambridge Breast Unit, Addenbrooke’s HospitalP29: INCIDENTAL METASTASES TO INTERNAL MAMMARY LYMPH NODES DETECTED DURING MICROVASCULAR ABDOMINAL FREE FLAP BREAST RECONSTRUCTION: A 15-YEAR REVIEWKY Wong, J Yu, V Broecker, P Forouhi, CM MalataCambridge University Hospitals NHS Foundation Trust P30: PATIENTS’ VIEWS ON USING COMPUTER DECISION AID SYSTEMS FOR TREATMENT OF BREAST CANCERV Jalali1,2, T Davidson1, T Kelleher1, D Whittaker1, N Williams2, D Acosta-Mena2, P Taylor2, M Keshtgar1, 2

1Royal Free London NHS Foundation Trust; 2University College LondonP31: THE GLUTEAL FOLD FLAP: A VERSATILE OPTION FOR PERINEAL RECONSTRUCTION FOLLOWING ANORECTAL CANCER RESECTIONNM Pantelides1, RJ Davies2, NS Fearnhead2, CMMalata1

1Department of Plastic and Reconstructive Surgery, Addenbrooke’s Hospital; 2Cambridge Colorectal Unit, Addenbrooke’s Hospital, Cambridge University Hospitals NHS Foundation Trust, CambridgeP32: THE USE OF ULTRASOUND IN THE ACUTE ABDOMEN IN THE SURGICAL ADMISSIONS UNITJ Torres-Grau, RKrysztopikRoyal United Hospital Bath P33: CONSENTING IN UPPER GASTROINTESTINAL SURGERY: AN AUDITS Constantinou, E Evgeniou, PA DimitriadisGeneral Surgery Department, Royal Berkshire Hospital, Reading

P34: RATIONALISING HISTOLOGY REQUESTS FOR CHOLECYSTECTOMY SPECIMENS JL Griffin, A Godfrey, NJ Carty Salisbury NHS Foundation Trust P35: DAY CASE AND READMISSION RATE OF ELECTIVE LAPAROSCOPIC CHOLECYSTECTOMY IN DISTRICT GENERAL HOSPITALNC Law, Wrightington Wigan and Leigh NHS trust P36: INTRAGASTRIC BALLOON IN THE MANAGEMENT OF MORBID OBESITYM Nnaji, JTham, R Welbourn, D MahonTaunton and Somerset NHS Foundation Trust P37: INVESTIGATION AND MANAGEMENT OF ACUTE PANCREATITISF Akter, Z Little, P Nastro, Ayman HamadeQEQM hospital P38: IMPROVING THE DIAGNOSTIC PATHWAY FOR LOWER GASTROINTESTINAL BLEEDINGA Wilkins, J Yee, M Kostala, M Cartmell, K CrossNorth Devon District HosptialP39: THYROID AND PARATHYROID SURGERY: ARE WE CHECKING THE VOICE?J Mayers1, S El-Shunnar2, E Diakos2, D Costello2

1University of Birmingham; 2Queen Elizabeth Hospital BirminghamP40: ANTIMICROBIAL ADHERENCE: ARE OTOLARYNGOLOGISTS FOLLOWING LOCAL GUIDELINES?N Ranga, JM Hindle, SK El-Shunnar, M WellerRussells Hall Hospital P41: DEFINING THE ROLE OF INTEGRINS IN THE REPAIR AND REGENERATION OF HAIR CELLS IN THE HUMAN VESTIBULAR SYSTEM K Hussain, A Forge, R Taylor, S SaeedUniversity College London Ear Institute P42: TOPONOME IMAGING SYSTEM: MULTIPLEX BIOMARKER POTENTIAL IN THORACIC ONCOLOGYR Evans1, B Naidu1,2

1Department of Thoracic Surgery, Heartlands Hospital Birmingham; 2School of Medicine, University of Warwick, CoventryP43: ADULT STEM CELLS IN THE HUMAN AND MOUSE SPINAL CORD: WHAT ARE THEIR CHARACTERISTICS AND CAN THEY MIGRATE AND REPLICATE UPON EXPOSURE TO GROWTH FACTORSS Stokes1,2, N Mani1,2, L O’Connor-Read1,2, Placzek1

1MRC Centre for Developmental and Biomedical Genetics, University of Sheffield; 2Sheffield Institute for Translational Neuroscience, University of Sheffield, SheffieldP44: EFFECTS OF SIMULTANEOUS BILATERAL STN AND PPN-DBS ON SACCADES IN ADVANCED PARKINSON’S DISEASEAN Khan, MJ Naushahi, S Khalid, D NandiImperial College London P45: SOCIAL NETWORKING USE BY PHYSICIANS AND MEDICAL STUDENTS IN IRELANDC Deane, NM Hogan, MJ Kerin, KJ SweeneyDiscipline of Surgery, School of Medicine, National University of Ireland, Galway P46: EFFECTS OF THE EUROPEAN WORKING TIME DIRECTIVE TWO YEARS AFTER IMPLEMENTATION: A SINGLE-CENTRE SURVEYCL Connelly | The University of Edinburgh

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P47: WITHDRAWNP48: TRANSLATING PATIENT SAFETY CONCEPTS INTO PRACTICE WITH DISCUSSION CARDSR Kwon, E Robertson, L Morgan, P McCullochUniversity of Oxford P49: INVESTIGATING LAPAROSCOPIC RELEVANT MOTOR LEARNING WITH A NOVEL RESEARCH TOOL: THE LAP-KATO Giles1, AD White1,2, EL Burns3, C Mole1, PR Culmer3, RM Wilkie1, M Mon-Williams1, JPA Lodge2

1Institute of Psychological Sciences, University of Leeds; 2Department of Hepatobiliary and Transplant Surgery, St James’s University Hospital; 3School of Mechanical Engineering, University of Leeds, LeedsP50: INTERCOLLEGIATE SURGICAL CURRICULUM PROGRAMME – WHERE ARE WE NOW?SG Coulson1, D Saleh2, J Rawlins2

1Department of Respiratory Medicine, Barnsley District General Hospital; 2Department of Plastic and Reconstructive Surgery, Pinderfields Hospital, WakefieldP51: A PROSPECTIVE ANALYSIS OF SLEEP DEPRIVATION IN SURGICAL PATIENTS R Dolan, J Huh, N Tiwari, J Camilleri-BrennanStirling Royal Infirmary, NHS Forth Valley P52: AUDIO-VISUAL AIDS FOR INFORMED CONSENT FOR INVASIVE HEALTHCARE PROCEDURES: A SYSTEMATIC REVIEWEH Farrell1, K Phillips1, B Morgan1, K Savage1, V Lewis1, RN Whistance2, M Kelly1, M Mann3, JM Blazeby2, K Kinnersley1, AGK Edwards1

1Cochrane Institute of Primary Care and Public Health, Cardiff University, Cardiff; 2Academic Unit of Surgical Research, School of Social and Community Medicine, University of Bristol, Bristol; 3Information Services, Support Unit for Research Evidence (SURE), Cardiff University, CardiffP53: CAN MIDDLE-GRADE SURGEONS PLAY A GREATER ROLE IN LAPAROSCOPIC INGUINAL HERNIA REPAIR WITHOUT COMPROMISING OPERATING LIST EFFICIENCY AND PATIENT SAFETY? AN AUDIT OF HERNIA REPAIRS AT A DISTRICT GENERAL HOSPITALR Vijayan, R Paul, K ToeMilton Keynes General Hospital P54: ARE WE COMPLYING WITH NATIONAL GUIDELINES IN THE ENT PREOPERATIVE ASSESSMENT CLINIC?NM Stobbs*, J Goswamy, M Karim, L RamamurthyDepartment of Otolaryngology Head and Neck Surgery, Stepping Hill Hospital, Cheshire P55: THE IMPACT OF SCREENING ON CLINICOPATHOLOGICAL DETERMINANTS OF OUTCOME IN COLORECTAL CANCER IN THE WEST OF SCOTLAND Y Grant1, D Mansouri1,2, E Crighton2, D McMillan2

1University of Glasgow; 2Glasgow Royal InfirmaryP56: A TOOL TO MEASURE SURGICAL DECISION MAKING IN EMERGENCY ADMISSIONSZM Jessop, N BeharChelsea and Westminster Hospital, LondonP57: THE LONDON BANGLADESHI COMMUNITY: A POPULATION PROTECTED AGAINST THE DISEASE OF WESTERN CIVILISATIONR Lahiri1, A Abeles2, K Burnand3, W Alazawi1, G Foster1, C Knowles2

1Department of Hepatology, Centre for Digestive Diseases, Barts and the London School of Medicine and Dentistry, London; 2National Centre for Bowel Research and Surgical Innovation, Centre for Digestive Diseases, Blizard Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London; 3Department of Paediatric Surgery, Bristol Royal Hospital for Children, Bristol

P58: ROLE OF ULTRASOUND SCANNING IN SUSPECTED ACUTE APPENDICITISPA Dimitriadis, J Lenihan, D McGrath General Surgery Department, Royal Berkshire Hospital, ReadingP59: RELATIONSHIP BETWEEN OMEGA-3 FATTY ACIDS AND COMPLEMENT ACTIVATION IN SEVERE SEPSIS DK Bilku, WY Chung, TC Hall, AR Dennison University Hospitals of Leicester P60: CONTEMPORARY MANAGEMENT AND CLASSIFICATION OF HEPATIC LEIOMYOSARCOMAM Hamed1, KJ Roberts1, W Merchant2, JPA Lodge1

1The Liver Unit, and 2Histopathology Department, St James’s University Hospital, LeedsP61: PREOPERATIVE EMERGENCY PATIENT AUDIT (PEPA): SECOND CYCLEM Gillam, R Llewellyn-Bennett, A Chaudhry, F Hamilton, R LongmanUniversity Hospitals Bristol TrustP62: PREOPERATIVE HAEMOGLOBIN: IS IT IMPORTANT IN THE SURGICAL MANAGEMENT OF GASTRIC ADENOCARCINOMAA Mirza, S Pritchard, I WelchDepartment of Gastrointestinal Surgery, University Hospital of South Manchester P63: WHAT IS THE VALUE OF PREOPERATIVE INVESTIGATIONS IN THE OUTCOME OF TEMPORARY SNS FOR MANAGEMENT OF FAECAL INCONTINENCE?M Feretis, S Karandikar, A Carter, MAS ChapmanDepartment of Colorectal Surgery, Heart Of England NHS Foundation Trust, BirminghamP64: SHORT-TERM AND SURROGATE OUTCOMES IN SURGICAL ONCOLOGY: THE NEED FOR CORE OUTCOME SETSNS Blencowe1,2, P Chana1, RN Whistance1,2, JM Blazeby1,2

1Centre for Surgical Research, University of Bristol; 2University Hospitals Bristol NHS Foundation TrustP65: EARLY CONSULTANT INPUT IMPROVES CARE OF PATIENTS UNDERGOING EMERGENCY LAPAROTOMYNC Law, Wrightington Wigan and Leigh NHS TrustP66: IS CURRENT NATIONAL GUIDANCE FOR BLOOD CROSS MATCH PRIOR TO HEMICOLECTOMY CLINICALLY JUSTIFIABLE OR COST EFFECTIVE?L Safarfashandi, M Patel, R Morjaria, G Phoenix, T Allen-MershChelsea and Westminster Hospital

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THE BRITISH ASSOCIATION OF UROLOGICAL SURGEONS (BAUS) SECTION OF ACADEMIC UROLOGY MEETINGThursday 10 January 2013

The BAUS Section of Academic Urology was formed in June 2007, joining the existing BAUS Sections of Oncology, Endourology, Andrology and Genito-Urethral Surgery, and Female, Neurological and Urodynamic Urology. The Section of Academic Urology aims to promote the development and expansion of high-quality academic urology in the UK and Ireland. It also aims to act as a forum for discussion of practical issues relating to clinical research. The Section is responsible for:

» working in conjunction with the BAUS Sections in order to foster an environment where clinical research can flourish;

» encouraging improved interaction between academic urologists and consultant urologists (in the NHS);

» acting as a reference point for fostering and facilitating high-quality research; » advising on potential sources of funding for research projects; » encouraging the participation of younger urologists in research and academic

urology; and » developing effective working relationships with allied groups and organisations.

The Section has a key link to the Scientific and Education Committee of The Urological Foundation and works to ensure that research interests across the specialty are supported.

The Section has joined SARS for the annual meeting since 2009 and is happy to be part of the 2013 meeting. The Section also organises a one-day meeting immediately preceding the BAUS Annual Meeting in June each year.

All sessions in Wimpole Lecture Theatre unless stated otherwise

08.15Registration

08.45Introduction and welcomeProfessor Rob PickardChairman, Section of Academic Urology

08.50Paper session (15 papers) (6+2 minutes)

10.50Coffee, trade exhibition and posters

11.20Poster presentations (12 papers) (3+2 minutes)

12.25Guest lecture: Biomarkers in OABProfessor Dirk De RidderUniversity Hospitals KU LeuvenIntroduced by Professor Prokar Dasgupta

13.00Lunch, trade exhibition and posters

14.00Patey Prize session 2 (7 papers) (7+3 minutes)Guy Whittle Auditorium

15.10Coffee, trade exhibition and posters

15.30Zachary Cope Lecture (see page 27)Guy Whittle Auditorium

16.00BJS Lecture (see page 27)Guy Whittle Auditorium

16.30Presentation of prizesGuy Whittle Auditorium

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08.50U1: Epigenetic profiling in urine for the detection of aggressive prostate cancerEM Bolton1*, D Moran1*, A Meunier1, A Vajda1, F O’Kelly1, J Thurman1, R O’Connor1, L Marignol3, D Hollywood3, TH Lynch2, AS Perry1

1Prostate Molecular Oncology Group, Institute of Molecular Medicine, Trinity College Dublin; 2Department of Urology, St James’s Hospital; 3Division of Radiation Therapy, School of Medicine, Trinity College Dublin

08.58 U2: BI0087 promotes aggressive prostate cancer by promoting tumour proliferation, migration and invasion LS Lee, A Ramos-Montoya, HC Whitaker, DE NealCambridge Research Institute

09.06U3: Real-time expression analysis of a microRNA signature of prostate cancer in prostate cell lines and tissue specimens EM Bolton EM1*, DC Moran1, A Meunier1, F O’Kelly1, L Marignol3, D Hollywood3, TH Lynch2, AS Perry1

1Prostate Molecular Oncology Group, Institute of Molecular Medicine, Trinity College Dublin; 2Department of Urology, St James’s Hospital; 3Division of Radiation Therapy, School of Medicine, Trinity College Dublin

09.14U4: The effect of Plexin B1 activation on prostate cancer cell motility A Damola, A Legendre, S Ball, M Williamson University College London

09.22U5: Investigating the regulation and effects on androgen receptor expression using a novel stem cell environment model of castration-resistant prostate cancerAC Hepburn, L Gaughan, SC Williamson, D Pal, M Moad, MK Kanani, CN Robson, R HeerNewcastle University, Northern Institute for Cancer Research

09.30U6: Identification of 23 novel prostate cancer susceptibility loci using a custom array (the iCOGS) in an international consortium, PRACTICALL Goh, R Eeles, A Amin Al Olama, S Benlloch, C Goh, E Saunders, D Leongamornlert, M Tymrakiewicz, The PRACTICAL Consortium, Z Kote-Jarai, D Easton The Institute of Cancer Research, Sutton

09.38U7: Stockpiling testosterone; a unique mechanism of progression to castrate-resistant diseaseSC Williamson, AC Hepburn, A Mantilla, L Wilson, HY Leung, CN Robson, R Heer Northern Institute for Cancer Research, Newcastle

BAUS SECTION OF ACADEMIC UROLOGY MEETINGPaper presentations | Chairs: Professor Craig Robson and Professor Kilian Mellon | Wimpole Lecture Theatre

09.46U8: Prostate cancer management over the last decade. Have we changed anything?R Turo, M Smolski, S Bromage, A Thompson, GN Collins Stepping Hill Hospital, Stockport

09.54U9: Exosomal RNA, urine biomarkers for prostate cancer. Our experience H Yazbek, J Clark, R Hurst, M Rochester, R Mills, K Sethia, D Edwards, C Cooper Norfolk and Norwich University Hospital

10.02U10: IL-15 promotes expansion of unique double positive CD4+CD8+ T cells and CD8+CD56+ T cell populations: relevance to prostate cancer immunotherapyOE Elhage, C Sakallariou, C Galustian, O Ukimura, IS Gill, RA Smith, P Dasgupta Kings College London, MRC Centre for Transplantation

10.10U11: The development of a validated data linked tissue microarray of bladder cancer patients undergoing cystectomyRR Robinson, S Anderson, S Verma, G Ashton, M Brown, C Womack, NW ClarkeThe Christie, Manchester

10.18U12: Comparison of the motility and NF-kappaB activating properties of clinical isolates associated with urinary tract infectionsML Lanz, P Aldridge, C Birchall, A Ali, C Townes, K Walton, LY Lim, RS Pickard, J HallInstitute of Cell and Molecular Biosciences, Newcastle upon Tyne

10.26U13: Biomechanical optimisation of a tissue engineered prosthesis for pelvic floor repairI Osman, S Roman, G Gigliobianco, AJ Bullock, C Chapple, S MacNeil Kroto Research Institute, University of Sheffield

10.34U14: Research evaluation of academic urology and development of speciality specific bibliometric scoring systemSF Froghi, K Ahdmed, J Fitzpatrick, MS Khan, P DasguptaMRC Centre for Transplantation, King’s College London, King’s Health Partners

10.42U15: Assessment of the learning curve of a single surgeon for robotic partial nephrectomy for t1a renal tumoursK Patel, M Billia, P Dasgupta, B Challacombe Guy’s and St Thomas’ NHS Foundation Trust

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BAUS SECTION OF ACADEMIC UROLOGY MEETINGPoster presentations | Chairs: Professor David Neal and Professor Howard Kynaston | Wimpole Lecture Theatre

11.20U16: Generation of induced pluripotent stem cells from human urinary tract cellsM Moad, A Hepburn, M Lako, D Pal, S Williamson, C Robson, R Heer Northern Institute for Cancer Research, Newcastle University

11.25U17: The efficacy of NMP22 in screening for early bladder cancerWM Abeysekera, S Patel, F Chinegwundoh, A KhattakNewham University Hospital

11.30U18: WITHDRAWN

11.35U19: Towards derivation of a distinct signature permitting personalised treatment in prostate cancerADG Lamb, NL Sharma, R Russell, A Ramos-Montoya, H Ross-Adams, H Whittaker, G Shaw, K Wadhwa, S Hori, A Warren, DE NealAddenbrooke's Hospital, Cambridge

11.40U20: Towards defining the mechanisms of docetaxel resistance in prostate cancerDJ Lundon, M Prencipe, S Madden, A O'Neill, P Doolan, S Ahearne, JM Fitzpatrick, RW WatsonUniversity College Dublin, National Institute for Cellular Biotechnology, Molecular Therapeutics for Cancer Ireland

11.50U21: Oncological outcomes of robotic assisted radical prostatectomy after more than five yearsM Billia, B Hallacombe, MS Khan, D Cahill, P DasguptaGuy's Hospital, King’s College London, King’s Health Partners

11.55U22: Outcomes following resection of renal cell carcinoma with extensive vascular and intracardiac extension JD Evans, AM Ranasinghe, SJ Rooney, RI Bhatt, TR GrahamQueen Elizabeth Hospital, Birmingham

12.00U23: Effects of holmium: YAG laser energy settings on fiber tip degradationZG Goldsmith, S Rai, A Neisius, GM Astroza, AJ Wang, MW Iqbal, WN Simmons, GM Preminger, ME LipkinDuke University Medical Center

12.05U24: Non palpable testicular masses – should we be worried?H Abboudi, S Malde, A Mchaourab, B Eddy, N Shrotri Kent and Canterbury Hospital

12.10U25: Clinical and educational patient education apps for urologyL LewisUniversity of Warwick

12.15U26: Learning curves for robot-assisted laparoscopic prostatectomyHA Abboudi, KA Ahmed, MSK Shamim-Khan, SF Froghi, PD DasguptaGuy’s Hospital, London

12.20U27: Urinary catheter related attendances to Accident and Emergency and assessing the effect of a catheter record sheetTGB Brenton, RB Begum, RB Barod, HC Chiffins, CBAOC CokerRoyal Sussex County Hospital

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BBA PROGRAMMEGovernors: Naiem Moiemen and Peter Butler

I am delighted to welcome you to our fourth consecutive year for the burns and plastic surgery section of SARS. The quality of abstracts has greatly improved over the years. This year the paper: Design of novel nanocomposite nerve conduits by Tina Sedaghati, Gavin Jell, Afshin Mosahebi, Peter Butler and Alexander M Seifalian from University College London was nominated for the Patey Prize.

Naiem MoiemenOn behalf of the British Burn Association.All sessions in the Seminar Suite unless otherwise stated.

07.30 Registration opens

09.00WelcomeMr Naiem Moiemen

09.15Gibson Prize Session, 9 papersChair: Dean Boyce and Rona Slator

10.45Coffee & Trade Exhibition

11.15Jackson Prize Session, 9 papersChair: Peter Dziewulski and Stuart Watson

13.00Lunch

BBA delegates are invited to join the main SARS meeting after lunch

14.00Patey Prize Session 2, 7 papers (7 min + 3 min)Chair: Professor Andrew Bradley and Professor Rob PickardGuy Whittle Auditorium

15.10Coffee, Trade Exhibition and Poster Rounds

15.30Zachary Cope Lecture Guy Whittle AuditoriumThe androgen receptor and prostate cancerDavid NealProfessor of Surgical OncologyAddenbrooke’s Hospital, CambridgeChair: Professor Derek Alderson

16.00BJS Lecture Guy Whittle AuditoriumAttempts to innovate in coloproctology and beyondProfessor Norman WilliamsPresident, The Royal College of Surgeons of EnglandWe gratefully acknowledge the support of The BJS for this lecture

16.30Presentation of Prizes Guy Whittle Auditorium

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09.15BP1: The methodological quality of RCTs in plastic surgery needs improvement – a systematic reviewRA Agha1,2, CF Camm3, E Edison4, DP Orgill51 National institute for Health and Clinical Excellence Scholar, London, UK; 2Department of Plastic Surgery, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, UK; 3Oxford University Medical School, Oxford, UK; 4University College London Medical School, London, UK; 5Division of Plastic Surgery, Department of Surgery, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA

09.25BP2: The reporting quality of RCTs in plastic surgery needs improvement – a systematic reviewRA Agha1,2, CF Camm3, E Doganay4, E Edison5, MRS Siddiqui6, DP Orgill71National institute for Health and Clinical Excellence Scholar, London; 2Department of Plastic Surgery, Queen Victoria Hospital NHS Foundation Trust, East Grinstead, UK; 3Oxford University Medical School, Oxford, UK; 4University of Southampton Medical School, Southampton, UK; 5University College London Medical School, London; 6St Marks Hospital, Harrow, UK; 7Division of Plastic Surgery, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

09.35BP3: Primary reattachment for narrow pedicle ear avulsionLCE Martin, H Jones, H Schumacher, M Dickson | East and North Hertfordshire NHS trust

09.45BP4: Experience with ruptured PIP breast implants: an algorithmic approachNG Cunniffe, AM Blake, NG Patel, CM Malata | Plastic Surgery Department and Cambridge Breast Unit, Addenbrooke’s University Hospital, Cambridge

09.55BP5: Combination cosmetic surgery – an individual surgeon’s experience in non-post massive weight loss patientsZM Jessop, JT Yu, E Erel, CM MalataPlastic Surgery Department, Addenbrooke’s University Hospital, Cambridge University Hospitals NHS Foundation Trust

10.05BP6: The management of ulnar duplication polydactyly: the six-year Coventry and Warwickshire experienceZeeshan Ahmed, Dept of plastic surgery, UHCW, Coventry

10.15BP7: Outcomes of peripheral nerve schwannoma excision in nf2 patients are as good as in non-nf2 patients – a case control studyC Bendon, D Furniss, H Giele | Department of Plastic, Reconstructive & Hand Surgery, Oxford University Hospitals NHS Trust

10.25BP8: Reinnervation of the interscutularis muscle after nerve repair or graft in yfp miceACS Woollard1,2, K Rolfe1, JW Lichtman2, AO Grobbelaar1 | 1The Royal Free Hospital (UCL); 2Harvard University

10.35BP9: Peripheral nerve compression in nf2 patientsC Bendon, H Giele | Department of Plastic, Reconstructive & Hand Surgery, Oxford University Hospitals NHS Trust

11.15BP10: 105 cases of preventable in scald burnsQ Frew, S Jabir, P Dziewulski | St Andrews Burns Unit

11.25BP11: Distribution of motor vehicle radiator-related burns: a ten-year reviewS Ali, Q Frew, P Dziewulski | St Andrew’s Centre for Plastic Surgery and Burns, Broomfield Hospital, Chelmsford

11.35BP12: Evaluation of a resuscitation formula for paediatric burns that includes albuminA Souéid, N Moiemen | Burns Centre, QEHB, Birmingham

11.45BP13: Hypertrophic scarring in paediatric burns: can we really wait three weeks?E Chipp, L Charles, K Whiting, C Thomas, N Moiemen, Y Wilson | Burns Centre, Birmingham Children’s Hospital

11.55BP14: Tissue targeted regulatory t cell therapy prevents human skin allograft rejection in a humanised mouse modelF Issa, J Hester, K Milward, R Goto, KJ Wood | Transplantation Research Immunology Group, University of Oxford

12.05BP15: A new class of nanoantibiotics directed at multidrug resistant surgical infection – ex vivo release kinetics and targeting potentialEA Azzopardi, EL Ferguson, DW Thomas | School of Dentistry, Cardiff University, Cardiff and The Welsh Centre for Burns and Plastic Surgery, Morriston Hospital Swansea

12.15BP16: Design of novel nanocomposite nerve conduitsT Sedaghati1, G Jell1, A Mosahebi1,2, P Butler1,2, AM Seifalian1

1Centre for Nanotechnology & Regenerative Medicine, UCL Division of Surgery & Interventional Sciences, University College London, London, UK; 2Department of Plastic and Reconstructive Surgery, Royal Free Hampstead NHS Trust Hospital, London

12.25BP17: Maximising efficiency in plastic surgery operating theatres: lessons from a review of theatre utilisation, delays and cancellationsA Jordan, N Sheppard, S Benyon | Cambridge University Hospitals

12.35BP18: Membership benefits survey of plastic surgical societies in developed countries: a postal questionnaire comparison of trainee versus consultant surgeonsC Parker1, AK Shah1, CF Halbert2, CM Malata1

1School of Clinical Medicine, University of Cambridge, Addenbrookes Hospital, Cambridge, UK; 2Orellia Soldiers Memorial Hospital, Orellia, Ontario, Canada

BBA SESSIONSGibson Prize | Thursday 10 January 2013Seminar Suite | Chairs: Dean Boyce and Rona Slator

Jackson Prize | Thursday 10 January 2013Seminar Suite | Chairs: Peter Dziewulski and Stuart Watson

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PROFILES OF SARS COUNCIL MEMBERS 2012

Professor J Andrew Bradley Professor Cliff Shearman Professor Alun Davies

President President Elect Honorary Secretary

Andrew Bradley is Professor of Surgery and Head of the Department of Surgery at the University of Cambridge. He is a transplant surgeon at Addenbrooke’s Hospital, Cambridge. After qualifying MB ChB in Leeds (1975), he undertook surgical training in Leeds and Glasgow where he completed a PhD before his appointment as an NHS consultant surgeon at the Western Infirmary,

Glasgow. In 1994 he was appointed Professor of Surgery and Immunology at the University of Glasgow, before moving to the Chair of Surgery in Cambridge in 1997. He is a fellow and past member of the Council of the Academy of Medical Sciences, past President of the British Transplantation Society and the British Society of Histocompatibility and Immunogenetics, and past Secretary and Treasurer of the International Transplantation Society. His research interests range from basic aspects of transplant immunology to the clinical evaluation of novel immunosuppressive agents and investigation of the donor and recipient factors that influence outcome after kidney transplantation. He is Editor of the Journal of Transplantation, an Associate Editor of the American Journal of Transplantation and chairs the Kidney Transplantation Advisory Group at NHS Blood and Transplant.

Cliff Shearman is a Professor of Vascular Surgery at the University of Southampton and Consultant Vascular Surgeon at the University Hospital Southampton Foundation Trust. He qualified from Guy’s Hospital Medical School, London University, and trained in vascular surgery in Birmingham. He was appointed as a senior lecturer/consultant vascular

surgeon at the Queen Elizabeth Hospital, Birmingham in 1990. In 1994 he moved to Southampton as an NHS consultant vascular surgeon and in 1999 was appointed to the Chair of Vascular Surgery at the University of Southampton.

He currently works in a busy vascular unit, which undertakes most vascular and endovascular treatments of arterial and venous disease. The unit serves a local population of 1.2 million people. His research programme is largely directed at determining factors, both environmental and genetic, that promote the progression of vascular disease and how these might be modified, particularly in diabetes.

He is currently Associate Medical Director for Research and Development. He was a Council member and Chairman of the Training and Education Committee of the Vascular Society of Great Britain and Ireland, and President of the Vascular Society (2009–2010). He was Head of the Wessex Postgraduate School of Surgery (2007–2012) and appointed chair of the newly formed Vascular Specialist Advisory Committee in 2012.

Professor Alun Davies is Professor of Vascular Surgery and Honorary Consultant Surgeon at Imperial College, Charing Cross and St Mary’s Hospitals, London. He trained in Cambridge, Oxford, Plymouth, Boston (USA) and Bristol, prior to taking up a senior lecturer appointment in 1994. Professor Davies has been a Hunterian Professor and Arris and

Gale Lecturer at the Royal College of Surgeons, Abdol Islami Scholar at the American College of Surgeons, and Fellow Emeritus of the Australasian College of Phlebology. He is the Editor-in-Chief of Phlebology and Venous Times. He is past President of the European Venous Forum, past President of the UK Venous Forum at RSM, past council member of the Vascular Society of Great Britain and Ireland and member of the American Venous Forum, the American College of Phlebology and European Society of Vascular Surgery. His main research interests are clinical trials and basic science research related to venous and carotid artery disease. He has written and edited numerous books and published over 300 research papers on many aspects of vascular disease and has lectured in many parts of the world on a wide range of vascular topics. He examines for the Intercollegiate Board of RCS and the European Board of Vascular Surgery and is Chairman of a NICE guidelines committee.

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Dr Sarah Watts Mr Robert Hinchliffe Professor Dileep Lobo

Dr Sarah Watts is a Principal Scientist in the Biomedical Sciences Department at the Defence Science and Technology Laboratory (DSTL) in Porton Down. She graduated from the Royal Veterinary College (RVC), University of London, in 1994 and is a member of the Royal College of Veterinary Surgeons. She spent three years working in a mixed veterinary practice before returning to RVC to undertake a PhD, which was awarded in 2001. She has worked at DSTL since 2000 and has been an academic lead for a research programme that addresses the current and emerging research requirements in combat casualty care for the Surgeon General’s Department since 2003. She also supervises and mentors military surgical trainees registered for higher research degrees.

Mr Robert Hinchliffe qualified from Bristol University, underwent his general surgical training in in Nottingham and was awarded an MD thesis for work on endovascular repair of ruptured abdominal aortic aneurysms. He undertook an endovascular fellowship in Malmo, Sweden, and became a National Institute of Health Research (NIHR)

Clinical Lecturer in Vascular Surgery at St George’s, University of London, in 2008. He received a Clinical Senior Lectureship award from the Higher Education Funding Council for England and took up a post as an honorary consultant in Vascular Surgery at St George’s Vascular Institute in 2011. Mr Hinchliffe has clinical interests in endovascular surgery and diabetes-related complications of the lower limb. His research interests are focused on clinical trials and the introduction of new technology into surgical practice, for which he has received grants from the British Heart Foundation and the NIHR’s Health Technology Assessment programme.

Dileep Lobo is Professor of Gastrointestinal Surgery and Consultant Hepatopancreaticobiliary Surgeon at Queen’s Medical Centre, Nottingham. He qualified from Bangalore University in India and has trained in Chandigarh, Nottingham and Leicester. He was awarded a Doctor of Medicine degree with distinction by the

University of Nottingham for his work on fluid and electrolytes and is a recipient of the Sir David Cuthbertson Medal for his contributions to the field of nutrition and metabolism. His clinical interests focus on surgery of the pancreas and biliary tree and laparoscopic surgery. His research interests include surgical nutrition and metabolism, fluid and electrolyte balance and pancreatic cancer. Dileep is the local Special Interest Group Lead in Surgery for the UK Comprehensive Clinical Research Network. He is also the Surgical Lead for the Nottingham Digestive Diseases Centre NIHR Biomedical Research Unit. He is a member of the editorial board of four peer-reviewed journals and has over 140 publications in peer-reviewed journals. He has lectured both nationally and internationally. He has been awarded the Fellowship of the American College of Surgeons in 2010 and is a member of the scientific committees of the European Society for Clinical Nutrition and Metabolism, the Enhanced Recovery After Surgery Society and the International Society for Surgical Metabolism and Nutrition.

Honorary Treasurer Editorial Secretary Programme Chair

ANNuAl meetiNg 201338

Dr Marilena Loizidou Professor Michael Nicholson Mr Bijan Modarai

Dr Marilena Loizidou is a non-clinical senior lecturer in the Division of Surgery and Interventional Science, University College London (UCL) Medical School, Royal Free Campus. Previously she worked in the Academic Department of Surgery at Southampton University. She trained as a biochemist and a pharmacologist, first in Canada and later in the UK. She has been

involved in academic surgical training throughout her career, supervising more than 30 postgraduate surgeons working towards higher research degrees. She is a tutor of the MSc programme in Surgical Sciences at UCL. She designed and is director of the intercalated BSc in Surgical Science and the MSc in Nanotechnology and Regenerative Medicine at UCL. Her research programme focuses on using nanotechnology in cancer targeting, specifically in therapeutics of colorectal cancer and liver metastases. Additional research areas include multidrug-resistant solid cancers. She is an assistant editor for colorectal cancer at Oncology News and for the International Scholarly Research Network’s open-access journal, ISRN Oncology.

Professor Michael Nicholson qualified in Nottingham and trained in Bristol, Nottingham, Oxford and Leicester. He has been an honorary consultant surgeon for 20 years and has held the Chair of Transplant Surgery at the University of Leicester for the last 16 years. His clinical interests include renal transplantation, vascular access surgery and

endocrine surgery. His research interests are in the fields of renal ischaemia reperfusion injury, normothermic organ preservation and chronic kidney allograft damage. Twenty-four of his clinical research fellows have been awarded the degree of MD and three of them now hold a chair of surgery. He has published more than 300 papers.

Bijan Modarai is a Senior Lecturer in Vascular Surgery in King’s College London and Honorary Consultant Vascular Surgeon at Guy’s and St Thomas’ NHS Foundation Trust. He was awarded a British Heart Foundation Intermediate Clinical Research Fellowship in 2011. He won the Patey Prize for his research work on the role of

angiogenesis in thrombus resolution and graduated with a PhD in Biochemistry in 2006. His research interests include angiogenesis in tissue remodelling, angiogenic cell therapy and novel imaging techniques applied to vascular disease.

Membership Chair Council Member Council Member

ANNuAl meetiNg 2013 39

Professor Charles Knowles Professor Steve White Professor Ajith Siriwardena

Charles Knowles is Professor of Surgical Research at Queen Mary University of London and Consultant Colorectal Surgeon at Barts Health NHS Trust. He qualified from the University of Cambridge and undertook general surgical training in London before being awarded a HEFCE clinical senior lectureship (2006–2011). He is research lead of the Neurogastroenterology Section

of the British Society of Gastroenterology, Deputy Clinical Director of the NHS Bowel Healthcare Technology Cooperative and Chair of the Gastrointestinal Neuromuscular Pathology International Working Group. He is the author of over 90 peer-reviewed publications and 5 books. His main research interests are the pathoaetiology of gastrointestinal neuromuscular diseases; the molecular basis of gut sensorimotor dysfunction, particularly in relation to chronic abdominal pain; the role of colorectal physiological tests when guiding therapy in conditions such as constipation and faecal incontinence (especially focusing on clinical trials of neuromodulation).

Professor Steve White works in a busy supra-regional liver unit, which involves both liver/pancreas oncology and transplantation of the kidney, pancreas and liver. He also has a major interest in advanced laparoscopic surgery and cell transplantation. Over the years he has been very fortunate to work in some highly productive academic institutions. He is a strong believer

in the development of research among surgical trainees and actively encourages this in the north east, having developed and self-funded a successful surgical research training programme.

Professor Ajith Siriwardena is an NHS consultant surgeon in non-transplant hepatobiliary and pancreatic (HPB) surgery. He leads a clinical and basic science research programme, which initially focused on pancreatitis but now encompasses clinical oncology with specific interests in colorectal hepatic megastases. He is a strong advocate for academic endeavour

in complex craft-based branches of medicine and has taken 11 trainees to MD level and 1 to PhD in the last decade. In 2008 he received the ASiT’s Silver Scalpel Award for Best Surgical Trainer in the UK.

Council Member Council Member Council Member

ANNuAl meetiNg 201340

Professor Phil Drew Professor Rob Pickard Mr Vimal Gokani

Professor Phil Drew is an NHS consultant surgeon in oncoplastic breast surgery and Honorary Professor of Surgery at the Royal Cornwall Hospitals Trust in Truro, Cornwall. He was appointed as a senior lecturer in the Academic Surgical Unit in Hull in 2000, achieving a Chair in Tissue Engineering in the Hull York Medical School in 2005. While helping to

develop the unit in Cornwall, he maintains close links with Hull and in particular the basic science research into radio and chemo resistance. Professor Drew was a council member and treasurer at SARS in 1998 and his research interests include MRI and breast disease, quality of life and breast surgery,and proteomics of radio/chemoresistance. He is Deputy Medical Director with a portfolio for research and education, and a council member of the American Board of Surgery.

Professor Rob Pickard trained in urology at Freeman Hospital in Newcastle and was originally an NHS consultant before moving to a university post in 2004. His main clinical and research interest is in benign lower urinary tract disease, particularly lower urinary tract dysfunction, urethral stricture and neurourology. He has been Professor

of Urology in Newcastle since 2009 and co-led a laboratory research group with Dr Judith Hall, investigating innate immunity against urinary tract infection – particularly the interplay between toll-like receptor signalling and release of antimicrobial peptides, which act as the human body’s own antibiotics. On the clinical research side, he is active in large multi-centre clinical trial design, funding and delivery, and also secondary research by systematic review, meta-analysis and modelled prediction of cost-effectiveness. Professor Pickard also contributes to medical device development for urodynamic measurement.

After qualifying from Barts and The London, Vimal Gokani completed foundation training in the North East Thames Deanery. He undertook an MSc in Surgical Sciences at Imperial College London, where he was awarded a distinction. His research looked into vascular malformations and their symptomatology. Vimal

moved to the Midlands to commence an NIHR academic clinical fellowship in vascular surgery in Leicester, and is now a British Heart Foundation clinical research training fellow at the University of Leicester. His main research interests are in the effects of vascular surgery on central aortic haemodynamics.

Council Member BAUS Section of Academic Urology Representative ASiT Representative

ANNuAl meetiNg 2013 41

PROFILE

Mr Frank CT Smith

President of Royal Society of Medicine’s Section of Surgery, 2012–2013

Mr Frank Smith is a Reader in Surgical Education at the University of Bristol and an Honorary Consultant Vascular Surgeon at Bristol Royal Infirmary. After graduating from Birmingham University, he trained in Edinburgh, the West Midlands, Exeter and Bristol. He was awarded Peter Clifford and RCS Edinburgh Travelling Fellowships in 1996, enabling him to undertake further vascular training in Boston, Denver, Los Angeles and Seattle. Research interests have encompassed systemic effects of reperfusion injury in aortic aneurysm surgery, distal bypass surgery and intermittent claudication, in addition to the pathology and attenuation of myointimal hyperplasia. He has specific interests in medical education. He was Honorary Secretary of the Society of Academic and Research Surgery 2009–2012. He is a past Intercollegiate Basic Surgical Skills Tutor at The Royal College of Surgeons of England. He has represented the South West as Regional Specialty Professional Advisor on the Council of the Association of Surgeons of Great Britain and Ireland (ASGBI), and is currently Programme Director for the Confidential Reporting System for Surgery (CORESS), representing ASGBI on the Steering Group of National Confidential Enquiry into Patient Outcome and Death (NCEPOD). He is a member of the Specialist Advisory Committee for Vascular Surgery, examiner for the Intercollegiate MRCS and Chair of the Quality Assurance Board for the Fellowship of European Boards of Vascular Surgery (FEBVS) examinations.

42 ANNuAl meetiNg 2013

John Farndon Lecture

Professor Arnold DK Hill

British Journal Of Surgery Lecture

Professor Norman Williams

Professor Hill, a graduate of University College Dublin, is Professor of Surgery and Chairman of the Department of Surgery at The Royal College of Surgeons in Ireland and at Beaumont Hospital, Dublin. He did his basic surgical training in Dublin and his middle grade surgical training in London. He did a two-year basic research fellowship with Dr John Daly at The Hospital of the University of Pennsylvania and The New York Hospital-Cornell Medical Center in the United States.

He returned to Ireland to do his senior registrar training on the National Training Programme in Ireland. He also did a clinical fellowship in surgical oncology at Memorial Sloan-Kettering Cancer Center in New York, prior to taking up his first consultant appointment at St Vincent’s University Hospital in Dublin.

His clinical interests are in the area of breast cancer and melanoma. His laboratory research interests are in the transcriptional control of breast cancer, in particular the role of the coregulatory proteins in endocrine resistance. In January 2006, Professor Hill took up the Chair of Surgery at The Royal College of Surgeons of Ireland and transferred his clinical practice to Beaumont Hospital, Dublin – the principle teaching hospital of the RCS Ireland.

Professor Norman Williams, Consultant Colorectal Surgeon, became College President in July 2011. He is Professor of Surgery and Director of Innovation at the Academic Surgical Unit of Barts and The London, Queen Mary’s School of Medicine and Dentistry. His main clinical interests are sphincter preservation and reconstructive surgery, and his scientific interests are concentrated on gastrointestinal motility and anorectal physiology.

Professor Williams was elected as a Council member and trustee of the College in 2005, and most recently chaired the Research and Academic Board and the Invited Review Mechanism, and was Lead for the National Fellowship Scheme. Prior to being elected as College President, he was President of the Society of Academic and Research Surgery

and President of national patient charity The Ileostomy And Internal Pouch Support Group. Professor Williams has also been Chairman of the UK Coordinating Committee on Cancer Research committee on colorectal cancer, President of European Digestive Surgery, President of The International Surgical Group and Vice Chairman of the British Journal of Surgery.

Professor Williams is joint editor of Bailey and Love’s Short Practice of Surgery, co-author of Surgery of the Anus, Rectum and Colon and is a trustee of Bowel And Cancer Research. He is a Fellow of the Academy of Medical Sciences, an Honorary Fellow of The American Surgical Association, and in 2011 gave the prestigious Hunterian Oration at the College and was awarded The Cutlers’ Surgical Prize.

GUEST SPEAKER PROFILES

43ANNuAl meetiNg 2013

Zachary Cope Lecture

Professor David Neal

David has been Professor of Surgical Oncology and Honorary Consultant Urologist in Cambridge since 2002. Previously, he was Professor of Surgery, Head of School of Surgical and Reproductive Sciences and Director of Research at the University of Newcastle-upon-Tyne. His main areas of interest are in clinical and translational studies of prostate cancer, in particular the molecular abnormalities of androgen receptor signalling and gene alterations in prostate cancer. He has published over 500 articles, chapters and books. Clinically, his main interest is urological oncology, including robotic prostatectomy and retroperitoneal surgery.

He won the St Peter’s Medal (British Association of Urological Surgeons) in 2001 and is a founding Fellow of

the Academy of Medical Sciences (1998). He was an elected Council member of The Royal College of Surgeons of England in 2002 and in 2012 became Co-Chair of the Prostate Cancer Advisory Group. He was a member of the cancer sub-panel of Research Assessment Exercise in 2008 and an appointed member of the Postgraduate Medical Education and Training Board.

His research is funded through a programme grant from Cancer Research UK, and grants from the Health Technology Assessment of NIHR, the Medical Research Council, the EU and the National Cancer Institute.

44 ANNuAl meetiNg 2013

HONORARY SECRETARY’S REPORT

This has been a year of change for SARS with new members of Council appointed and others retired. To the latter I would like to extend a large vote of thanks for their hard work in helping to make the Society prosper. A further big vote of thanks is owed to Sarah King who administers the Society.

This year we have a joint venture with the Surgical Section of the Royal Society of Medicine and this should be an academically challenging meeting for all. We are delighted that the Association for Surgeons in Training, British Association of Urological Surgeons and British Burn Association are joining us again at our annual meeting. The locations for the 2014 and 2015 meetings have been agreed and are Cambridge and Durham respectively.

2013 sees the Presidency pass on to Professor Cliff Shearman and we would like to thank Professor Andrew Bradley for his hard work in leading the Society for the past two years. It is also my pleasure to inform you that Professor Dion Morton has been appointed as our President Elect.

Council is keen to focus on recruiting more members to join the Society and hopes that it will be able to help foster links between those starting off in surgical research careers and those who have experienced the highs and lows of academic life.

Alun DaviesHonorary Secretary

The accounts for the year ending 31 December 2011 demonstrate that SARS is financially stable and the Society’s thanks go to the previous Treasurer and Council members for their hard work. I will continue to ensure the Society remains in a strong financial position.

The accounts for 2011 show that there was a slight fall in revenue from subscriptions in 2011 but the Council and, in particular, the Membership Chair have been working hard in 2012 to retain members as well as encouraging new ones. The simplified application process, whereby applicants now only require one proposer, will hopefully help.

The Society’s investments have remained untouched, although the income generated from them has been low owing to the recession and it is not anticipated that this situation will change over the next few years. The Council is examining alternative investment opportunities to help boost income.

The annual meeting in Dublin was particularly successful, with the income generated significantly enhancing the Society’s finances. Our thanks go to the organisers for their achievement. It would appear from the accounts that the annual meeting had minimal costs compared with previous years; however, this is misleading and is because the majority of the income and expenses were processed through The Royal College of Surgeons in Ireland (RCSI), with the net profit being paid to SARS after the meeting. The expenses incurred by the RCSI were of similar magnitude to costs associated with previous SARS meetings.

Sarah WattsHonorary Treasurer

HONORARY TREASURER’S REPORT

ANNuAl meetiNg 2013 45

ANNUAL SARS ACCOUNT – YEAR END 2011

Statement of financial activities for the year ended 31 December 2011

Income and expenditure Total (£)

Incoming resources:

Subscriptions 15,434

Donations from meetings 71,673

Investment income 2,771

Total incoming resources 89,878

Resources expended

Charitable activities

Grants and prizes awarded 450

Meetings costs (* see note in Treasurer’s report) 7,508

Journal subscription 3,879

Office and other costs 32,106

Governance costs

Accountancy – current year 3,024

Committee meetings and trustees expenses 2,318

Bank charges 13

Miscellaneous 29

Total resources expended 49,327

Net income/(expenditure) for the year 40,551

Other recognised gains and losses

(Losses)/gains on investments (9,438)

Net movement in funds 31,113

Balance brought forward at 1 January 2010 95,889

Balance carried forward at 31 December 2010 127,002

ANNuAl meetiNg 201346

PRIZE RECIPIENTS 2012

Patey Prize REGULATORY B CELLS INDUCE LONG-TERM ALLO-GRAFT SURVIVAL IN A MOUSE MODEL OF CHRONIC REJECTION

M Mallik, CJ Callaghan, M Negus, JA Bradley, GJ PettigrewUniversity Department of Surgery, Addenbrooke’s Hospital, Cambridge Biomedical Research Centre, Cambridge, United Kingdom

Norman Williams Prize PLACEBO CONTROLLED DOUBLE BLIND RAN-DOMISED CLINICAL TRIAL OF TRANSVERSUS AB-DOMINIS PLANE BLOCK IN LIVE DONOR NEPHREC-TOMY

SA Hosgood, U Thiyaragarajan, JP Hunter, A Bagul, ML NicholsonUniversity of Leicester, Department of 3Is, Transplant Group

Kevin Burnand PrizeCHARACTERISATION OF QUIESCENT INTESTINAL STEM AND CANCER STEM CELLS

S Buczacki1, R Kemp1, A Klein2, RJ Davies3, D Winton1

1Cancer Research UK, Cambridge Research Institute, Cambridge, UK; 2Harvard Medical School, Boston, USA; 3Cambridge Colorectal Unit, Addenbrooke’s Hospital, Cambridge, UK

President’s Poster PrizePREOPERATIVE ORAL CARBOHYDRATE LOADING IN ELECTIVE SURGERY: A META-ANALYSIS

S Awad, KK Varadhan, M Kanagaraj, O Ljungqvist, DN LoboDivision of Gastrointestinal Surgery, Nottingham University Hospitals, Queen’s Medical Centre, Nottingham, UK

ANNuAl meetiNg 2013 47

SARS PAST PRESIDENTS AND HONORARY SECRETARIES

Year President Honorary Secretary

1954 Sir J Patterson-Ross Mr DH Patey

1956 Professor C Illingworth Mr DH Patey

1957 Professor C Illingworth Professor S Taylor

1958–9 Mr D H Patey Professor S Taylor

1960–61 Mr H B Atkins Professor R B Welbourn

1962 Professor Milnes-Walker Professor R B Welbourn

1963 Professor Milnes-Walker Professor APM Forrest

1964–65 Professor H Rodgers Professor APM Forrest

1966–67 Professor DM Douglas Professor G Smith

1968 Professor AW Kay Professor G Smith

1969–70 Professor AW Kay Professor HL Duthie

1971 Professor RB Welbourn Professor HL Duthie

1972 Professor LP Le Quesne Professor HL Duthie

1973 Professor LP Le Quesne Professor R Shields

1974 Professor APM Forrest Professor R Shields

1975 Professor APM Forrest Professor PRF Bell

1976–77 Professor GW Taylor Professor PRF Bell

1978 Professor HL Duthie Professor PRF Bell

1979 Professor HL Duthie Professor A Cuscheri

1980–81 Professor R Calne Professor A Cuscheri

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1982–83 Professor HAF Dudley Professor DC Carter

1984–86 Professor R Shields Professor I Taylor

1987 Professor PRF Bell Professor I Taylor

1988–89 Professor GR Giles Professor RFM Wood

1990 Professor NL Browse Professor RFM Wood

1991 Professor NL Browse Professor JR Farndon

1992–93 Professor LE Hughes Professor JR Farndon

1994–96 Professor TPJ Hennessy Professor RE Mansel

1997 Professor D C Carter Professor JRT Monson

1998 Professor JD Hardcastle Professor JRT Monson

1999–2000 Professor WD George Professor JRT Monson

2001–02 Professor D Boucher-Hayes Professor JRT Monson

2003–04 Professor BJ Rowlands Mr MG Wyatt

2005–06 Professor I Taylor Mr MG Wyatt

2006–07 Professor I Taylor Professor A Hill

2007–08 Professor K Burnand Professor A Hill

2008–09 Professor K Burnand Professor A Hill

2009–11 Professor N Williams Mr FCT Smith

2011–12 Professor JA Bradley Mr FCT Smith

2012–13 Professor JA Bradley Professor A Davies

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CONSTITUTION OF THE SOCIETY OF ACADEMIC AND RESEARCH SURGERY

Aim

SARS is the principal society concerned with academic surgery in the UK and Ireland. Its mission is to promote excellence in surgical research, education and clinical innovation and it does so through the exchange of information and ideas related to surgery, surgical disease, and surgical education. To this end it enables younger surgeons and scientists, particularly those in training, to present their research findings at its scientific meetings, the main one of which is the SARS Annual Meeting.

Scope

The Society was founded as the Surgical Research Society (SRS) in 1954 and subsequently changed its name to Society of Academic and Research Surgery (SARS) in 2001 to better reflect its goal of supporting not only surgical research, but also other aspects of academic surgery, particularly teaching and training, and more specifically the role of research in surgical training. All types of research relevant to surgery are supported, ranging from basic laboratory research through to clinical trials and health service research. In addition to the annual meeting, SARS also organises ad hoc meetings and hosts sessions at other major meetings, to support the development of young surgeons and surgical scientists. SARS is an inclusive society and encourages participation from surgeons, surgical trainees and scientists from all branches of surgery. It has close links with a number of other surgical societies in the UK, including the Association of Surgeons of Great Britain and Ireland, the Association of Surgeons in Training, the British Association of Urologic Surgeons, the Vascular Society of Great Britain and Ireland, and the Association of Upper Gastrointestinal Surgeons.

SARS Annual Meeting

The SARS Annual Meeting is held over a two-day period in January and typically attracts over 250 delegates comprising senior academics from different surgical disciplines, surgical trainees, medical students and surgical scientists. The meeting programme consists of high-quality oral presentations, selected from submitted abstracts presented in plenary as well as parallel sessions. One of the highlights of the annual meeting is the bestowing of the highly competitive David Patey Prize, named in honour of the founder of the Society and awarded to the person (normally a trainee) judged to have given the best presentation to the Society. There are also other prizes for outstanding presentations in basic and clinical science. In addition to high-quality oral and poster presentations, the SARS Annual Meeting incorporates invited presentations by internationally renowned leaders in their field, including the prestigious British Journal of Surgery Lecture and the John Farndon Memorial Lecture. The annual meeting is open to all members and their guests, including medical students and other healthcare professionals. The annual meeting attracts generous sponsorship from a range of companies and includes a trade display. A recent feature of the SARS Annual Meeting has been that it has been held in parallel with scientific meetings hosted by other specialist surgical societies, to allow their attendees to attend joint scientific sessions with SARS.

Membership and Relationships

The elected officers of SARS comprise the President, Honorary Secretary, Honorary Treasurer and Council members and the Annual General Meeting is held during the Annual SARS

Congress. There are currently nearly 250 members of SARS, including many of the senior academics and opinion leaders in UK surgery. Membership is open to all practising surgeons and others occupied in surgical research and teaching, and requires proposal by an existing member. The secretariat of SARS is based at The Royal College of Surgeons of England and SARS enjoys a close working relationship with the College and also with the Association of Surgeons of Great Britain and Ireland. The Society publishes a high-quality SARS Yearbook, a regular newsletter and has published influential contributions such as The Place of Research Issues in Professional Practice and Surgery in the Undergraduate Curriculum, all of which can be downloaded from the SARS website (www.surgicalresearch.org.uk). SARS also seeks to promote interchange of information internationally through collaboration with other national surgical societies and has developed close links with the American Association for Academic Surgery and American Society of University Surgeons, the South African Surgical Research Society and the European Surgical Research Society.

ANNuAl meetiNg 201350

THE ROYAL SOCIETY OF MEDICINE

The origins of the Royal Society of Medicine date back to the 18th century when throughout Europe medical societies began to be founded with the object of bringing together physicians and surgeons in order to further scientific, professional and social communication.

The Medical and Chirurgical Society of London was formed in May 1805 ‘for the purpose of conversation on professional subjects, for the reception of communications and for the formation of a library’. This society was the progenitor of the Royal Society of Medicine (RSM).

The RSM acquired a site on the corner of Wimpole Street and Henrietta Place in 1910. King George V and Queen Mary opened the final home of the Royal Society of Medicine at 1 Wimpole Street in May 1912.

Academic and professional benefits of RSM membership include: » One of the largest postgraduate medical libraries in Europe,

with on and offline facilities » 58 specialty sections and over 400 meetings a year, nearly

all with Continuing Professional Development accreditation » Journal of the Royal Society of Medicine » Online access to seven medical databases and nearly

1,000 full-text e-journals Membership also offers excellent club facilities which include: » Overnight RSM London accommodation at subsidised

prices, from only £126 per room » Members-only restaurant, bar, buttery, common room and

quiet rooms » Reciprocal clubs around the world » Fine wine, music and arts societies

» Free Wi-Fi serviceShould you wish to join the RSM you can visit www.rsmmembership.org and quote SARS13 to have the joining fee waived.

Section of Surgery

Aim: To provide a forum for the discussion and advancement of the art, science and practice of surgery.

History: The Section of Surgery was one of the original 13 Sections of the Royal Society of Medicine after its name was changed from the Medical and Chirurgical Society of London in 1907. The Section of Surgery hosted its first Council Meeting on 3 July 1907 with J Warrington Haward as its first President. The Section has had 93 Presidents in its 105-year history and was the first to approve sub-Sections, specifically orthopaedics, proctology and urology in 1913.

The Section of Surgery typically holds between four and six events per year and includes events held at the RSM, overseas and out of house meetings, prize meetings and a Presidential address. Mr Smith’s programme for 2012–2013 is below.

Previous meetings

Wednesday 3 October 2012: Presidential address 2012 – Surgical safety: Innovation and Education, and Norman Tanner Prize presentation.Delivered by Mr Frank Smith, President, Section of Surgery, RSMWednesday 9 – Thursday 10 January 2013: SARSA joint meeting of the Section of Surgery and the Society of Academic and Research Surgery

Future meetings

Sunday 27 January – Sunday 3 February 2013Winter ski and academic meeting in Champoluc, ItalyTrainees and medical students are encouraged to attendWednesday 13 – Thursday 14 March 2013Educational and careers meetingInvited national speakers and free paper sessionThursday 25 – Friday 26 April 2013Overseas academic meeting in StockholmTo include a visit to Karolinska Institute, StockholmThursday 20 – Friday 21 June 2013President’s day, Bristol

A joint meeting organised by the Section of Surgery and the Surgical Club of South West England, Bristol.

This will include the Adrian Tanner Prize and John Dawson Medical Student Prize presentations.

Section of Surgery prizes

» Norman Tanner and Glaxo Travelling Fellowship Prize » Medical Insurance Agency Prize » Adrian Tanner Prize » John Dawson Medical Student Prize

Consultants, academics, trainees and medical students are welcomed and encouraged to join in the activities of the Section of Surgery.

Contact for further information: surgery@rsm.ac.uk

The SocieTY of AcAdemic And ReSeARch SuRgeRY And The SecTion

of SuRgeRY, RoYAl SocieTY of medicine would like To ThAnk The

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