POSITIONS OPEN

FACULTY POSITIONMedical Oncology Division

USC/Norris Comprehensive Cancer CenterThe University of Southern California

The USC/Norris Comprehensive Cancer Centeris seeking a faculty member to hold and conduct anactive program in translational research in the area ofbreast cancer. The prospective candidate will be ap-pointed at the ASSISTANT/ASSOCIATE PRO-FESSOR level in the Department of Medicine, KeckSchool of Medicine at the University of Southern Cal-ifornia, Los Angeles, and will be expected to be an in-tegral participant and member of the Women_s CancerProgram at the Cancer Center. There is a competitivestartup and salary package with excellent benefits.Extensive Cancer Center core facilities for transla-

tional research are available, and their use by the can-didate for innovative bench research and correlativeand/or clinical trials will be encouraged. The patientpopulation at Norris Cancer Hospital, University Hos-pital, and LACþUSC Medical Center is a diverse andoutstanding resource for the conduct of clinical andcorrelative trials. At the USC Keck School of Medicineand USC/Norris Comprehensive Cancer Center, sig-nificant growth in clinical and translational research,in laboratory space resources, and in faculty recruit-ment will occur in the next five years as a high priorityof the University of Southern California.Minimum qualifications: translational and/or basic

research experience and clinical expertise in the area ofbreast cancer with a preference for clinical/translationaltrials and/or drug development. Candidates must beBoard-certified or equivalent in medical oncology. Back-ground in clinical and/or translational research, pos-session of a valid California medical license at the timeof appointment, and knowledge of scientific researchmethods will be required. Knowledge of federal guide-lines related to conducting clinical trials and tissue-based research and knowledge of quality assurance aswell as excellent spoken and written communication skillsare required. Candidates should be ready to function asindependent investigators with multidisciplinary teamsof mentors available. Applicants should electronicallysubmit curriculum vitae, and request three letters ofreference to be sent, to:

Michael F. Press, M.D., Ph.D.c/o Isabel Lora at e-mail: admedone@ccnt.usc.edu

The University of Southern California is an Equal Oppor-tunity Employer committed to excellence through diversity andstrongly encourages applications from all qualified applicants,including women and minorities.

RESEARCH MICROBIOLOGIST

Project description: A Research Microbiologist posi-tion is available in the Environmental Sciences and Bio-technology Department at the Savannah River NationalLaboratory (website: http://srnl.doe.gov) for a high-ly motivated individual with demonstrated experiencein microbiology, molecular biology, and biogeochem-istry. The successful candidate will join a multidisci-plinary team of investigators conducting transitionalresearch to elucidate and understand the expressedactivities and ecology of microorganisms in supportof U.S. Department of Energy missions. The successfulcandidate will participate in a wide variety of projectsranging from the microbial ecology of contaminatedenvironments to the genetics, physiology, and scale-upof biological energy production.Qualifications: The position requires a completed

B.S. or M.S. degree in a relevant field and demonstratedexperience in classical microbiological techniques, mo-lecular biology, microscopy, and analytical chemistry.The successful candidate must possess excellent writtenand oral communication skills.How to apply: Qualified applicants are encouraged to

submit a cover letter, detailed curriculum vitae, and ref-erence job number PR-EX-2009-00141 to the SRNLRecruiting Office at e-mail: srnlresearchrecruiting@srnl.doe.gov.

Savannah River National Laboratory is an Equal OpportunityEmployer, Minorities/Females/Persons with Disabilities/Veterans.U.S. citizenship is required. This appointment is open to all qual-ified U.S. citizens without regard to race, color, age, religion, sex,national origin, physical or mental disability, or status as a Vietnam-era veteran or disabled veteran.

POSITIONS OPEN

ASSISTANT OR ASSOCIATE PROFESSORCenter of Excellence for Infectious Diseases

The newly created Center of Excellence for Infec-tious Diseases at the Paul L. Foster School of Medi-cine, Texas Tech University Health Sciences Center,El Paso, Texas, is seeking candidates for tenure-trackfaculty positions at Assistant or Associate Professorlevel. This is part of a state-funded initiative to en-hance research in infectious diseases. The Center isprimarily interested in investigators with research in-terests in molecular immunology, host-pathogen in-teractions, vaccine development, and animal modelsfor translational studies.Successful candidates are expected to develop and

maintain independently funded research programs ininfectious diseases or a related field. The position re-ports to the co-directors of the Center of Excellencefor Infectious Diseases.Minimum qualifications: M.D. or Ph.D. degree in

a related field and at least three years of postdoctoralexperience with a strong publication record.Preferred qualifications: Candidates with funded

grant support and experience in emerging infectiousdiseases and cutting edge technologies are particu-larly encouraged to apply.The Center offers competitive salary and startup

packages, newly constructed laboratory space, BSL-2and BSL-3 laboratories, and a supportive interactiveenvironment. Interested candidates must apply onlineat website: http://jobs.texastech.edu, requisition#77147 by submitting curriculum vitae, a short write-up of research interests, and three letters of recom-mendation. For further information, please e-mail orcontact:

Manjunath Swamy, M.D.E-mail: manjunath.swamy@ttuhsc.edu or

Premlata Shankar, M.D.E-mail: premlata.shankar@ttuhsc.edu

Co-Directors of the Center of Excellence forInfectious Diseases

The positions are open until filled. Application re-view will begin immediately.

Texas Tech University Health Sciences Center is an EqualOpportunity/Affirmative Action Employer.

STANFORD UNIVERSITYNeuroscience Virus Core Facility Director

The Stanford Institute for Neuro-Innovation andTranslational Neurosciences (SINTN) seeks an out-standing and entrepreneurial molecular biologist/virologist to establish and direct a core facility to gen-erate viral vectors and distribute them to Stanford neu-roscientists. The successful candidate will have a Ph.D.and/or M.D., and several years of postdoctoral expe-rience with a strong track record in molecular biol-ogy and cell culture, ideally involving the generationand use of viruses (e.g. lentiviruses, AAVs). Salary willbe commensurate with experience. Please submit a cur-riculum vitae, statement of research experience and have3 letters of recommendation sent to: Kristy Verhines,email: ksn@stanford.edu.

Stanford University is committed to increasing representationof women and members of minority groups on its staff and par-ticularly encourages applications from such candidates.

POST-DOCTORAL POSITIONS are availableto study the molecular mechanisms regulating IgGand complement mediated neutrophil recruitment andeffector functions using in vitro and in vivo approaches.Strong background in cell biology/immunology andsmall animal experimentation especially intravital mi-croscopy is desired. Publication(s) in internationaljournals is a prerequisite. Please send CV and namesof 3 references to: Tanya Mayadas, Ph.D., AssociateProfessor of Pathology, Brigham and Women_sHospital and Harvard Medical School, 77 AvenueLouis Pasteur, NRB 752O, Boston, MA 02115.E-mail: tmayadas2@rics.bwh.harvard.edu; fax:(617) 525-4333.

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26 JUNE 2009 VOL 324 SCIENCE www.sciencecareers.org1736

UNITED STATES & CANADA

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In US/Canada call 202-326-6417 or 1-800-731-4939.In the rest of theworld call +44 (0) 1223 326515.

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The science job market in the London–Oxford–Cambridge triangle, after 10

years of rising public investment in the United Kingdom’s science base, has

never been stronger. But the shockwaves of the financial crisis are undermining

the biotech industry and pharma restructuring is hitting R&D, while academia is

refocusing research with a translational bent. By Nuala Moran

Like the curate’s egg, the scene for science jobs and recruitment in the

London–Oxford–Cambridge triangle is good in parts—the good being

those areas that, as yet, have escaped the fallout from the financial

catastrophe and the restructuring of the pharmaceutical industry; the

bad being those that have not.

To take the prime example of a bad part, the United Kingdom’s biotechnol-

ogy sector, based in the triangle, has been hard hit by the seizure in the capital

markets. In a survey of 295 companies carried out by the UK BioIndustry Asso-

ciation in March, 78 percent said they had found it more difficult to raise cash in

the previous 12 months. More than a third of companies trying to raise equity

financing failed to do so, while a further 47 percent were not able to obtain all

the financing they required.

With fewer products in the pipeline and sources of funding drying up, some

biotechs are shutting their doors. Others are cutting back to conserve cash and

try to hang on until the financing position improves. Companies in the region

that have announced staff cuts include Oxford-based Summit Corporation, a

zebrafish genomics specialist; Alizyme of Cambridge, which is developing

treatments for gastrointestinal diseases; and Silence Therapeutics of London,

an siRNA company.

Meanwhile, the pharmaceutical industry worldwide is undergoing the most

thorough restructuringandconsolidation in itshistory.Whilemanyof thepharma

job cuts of the past two years have involved sales and marketing divisions, the

UK’s previously strong position in pharmaceutical R&D and manufacturing has

left it especially exposed to these shifts.

To cite two examples, GlaxoSmithKline, the largest UK-based pharmaceutical

company, has announced the closure of threeUKR&Dsites in the past two years.

And with Pfizer and Wyeth accounting for over 6,000 jobs in the UK, employees

are braced for the job losses that will likely flow from their recent merger.

Accompanying these macroeconomic factors, changes such as the push to

interdisciplinary and translational research, as well as the addition of innova-

tion and technology transfer to the research and teaching remits of universities,

are changing the nature and practice of academic research and of science-re-

lated jobs.

The Fallout from PharmaDavid Rees, senior vice president of medicinal chemistry at Astex Therapeutics,

a fragment-based drug discovery specialist based in Cambridge, keeps a keen

eye on the recruitment market in the city. Medicinal chemistry has

LOOKING UP INA DOWNMARKET:CAMBRIDGE, OXFORD, AND LONDON

Changes such as the push to

interdisciplinary and translational

research are changing the nature

and practice of academic research

and of science-related jobs.

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FOCUS ONCAREERS AAAS/Science Business Office Feature

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Focus on Cambridge/Oxford/London

“Requirements are changing in response to the environment. Pharma

wants people who are adaptable, and are prepared to collaborate

and interact with the public and private sectors,” says Gales.

There is no less focusonscientific expertise. “Science is still the key

strength, but on the more commercial end of the business there is a

need for peoplewho can engagewith the payers and are comfortable

in dealings with regulators, health technology assessment bodies

such as NICE [the UK’s National Institute for Health and Clinical

Excellence], clinicians, and patient groups.”

Meanwhile, for those embarking on a career in the industry, a first

degree in science leaves a wide number of career avenues open. But

there is no doubt that scientists now need to offer commercial skills

as well. “As the two sides of pharmaceutical companies get closer

together, staff need to work in multifunctional teams, both internally

and externally,” says Gales.

Public Investment Continues to Create Jobs

After 10 years of rising public funding, the UK’s science base has

never been stronger. One manifestation of this investment is the

Diamond Light Source near Oxford, the largest science facility to be

built in the UK in the past 40 years. The synchrotron opened just over

two years ago and is still in the process of building up its operations.

Professor Trevor Rayment, physical sciences director, says 161 staff

are employed in physical sciences; at the full capacity of 15 beam

lines, this will rise to between 400 and 500.

Most recruits are academics, but there is a need for hybrid skills.

“You have to be capable of handling a big machine, and need to

enjoy troubleshooting and getting it to work well. And although our

scientists have their own projects, the emphasis is on providing a

service to our users,” says Rayment.

While public spending on science is at an all-time high, this has

been justifiedasan investment in theknowledgeeconomy. Inevitably,

this has repercussions in terms of the pressures universities are

coming under to adopt a more commercial focus in their research,

professionalize technology transfer, and collaborate with industry.

Universities such as Oxford, Cambridge, University College London

(UCL), and Imperial College pride themselves on their commercial

edge, and as a movement it is becoming hard for academic

researchers to resist, as several recent initiatives highlight.

For instance, beyond generalist technology transfer, the

Biotechnology and Biological Sciences Research Council (BBSRC)

is now funding Innovation and Knowledge Centres to promote

early commercialization of research in specific fields. An example

is Cambridge University’s center specializing in manufacturing

technologies for photonics and electronics. This combines research

with business development, market analysis, and commercial-

ization skills.

Another scheme is bringing industrial “moles” into the heart of

academe through Industrial Impact Fellowships. Researchers from

industry join existing projects and programs with a brief to support

translation of research. ScienceMinister Paul Drayson says, “Fellows

of this scheme will get to share their experience, skills, and contacts

directly with researchers—which is essential to bring innovations

from research to market rapidly.”

long been a specialty where skills are in short supply, but speaking

in March, Rees said there are far fewer job vacancies than 12months

ago. “There are many more people looking for jobs because of

downsizing in pharma.”

Whereas Astex and its biotech peers would previously have taken

doctoral students straight from university, “It is now possible to

recruit people from pharma with lots of experience in chemistry,”

says Rees.

As a consequence, some salaries are falling. “Astex is maintaining

salary levels—which have always been competitive with pharma—

but contract research organizations (CROs) are paying less.” Some

CROs are employing staff on short-term contracts to work on

specific projects.

A curious factor is a shift in the perception of risk. Whereas

scientists in big pharma previously expected to have secure jobs for

life, Rees believes they now have no greater sense of job security

than those in biotech.

“There still aren’t many unemployed chemists, but people do

accept the need to change company more often, and they may

need to look at a move as a way to reinvigorate their skill set,”

advises Rees.

The CEO of another development-stage Cambridge biotech, Tim

Brears of Xention, a discovery company specializing in ion channels,

agrees that the recruitment market in the city suddenly has a very

different feel. “We always expect quite a few applications when

we advertise, but since the pharma downsizing began we are

getting deluged.”

Pharma Changing Its Requirements

The restructuring of the pharmaceutical industry may be happening

under the cover of the global financial crisis, but it was sparked

by factors that are particular to the sector. These include patent

expirations, the rise of competition from generics, a downward

pressure on drug prices, increasing scrutiny from regulators and

health technology assessment bodies, pressure to move research

offshore, and the crisis in R&D productivity.

Ann Gales, a partner at the high-level recruitment consultancy

Heidrick and Struggles in London, advises that these pressures

are reflected in the kinds of people pharma now wants to recruit. continued » CR

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“Pharma wants people

who are adaptable,

and are prepared to

collaborate and interact

with the public and

private sectors.”

ScienceCareers.org

Qualified candidates willturn to this special featurefor information on:

• Which European countriesare increasing/decreasingfunding (FP7 update)

• What impact the currentglobal economy is havingon research in Europe

• Where the highest impactresearch is being done

Please contact yourScience Careers salesrepresentative.Telephone:+44 (0) 1223 326500E-mail:ads@science-int.co.uk

BONUSDISTRIBUTION

Biotechnica6–8OctoberHannover,Germany

Reserve ad space by8 September

Special Career Feature:

25September25September

Career Focus on

Europe

Group Leader

We are seeking a dynamic computational biologist, with a

proven track record, to establish a new research group to

complement our current programme.

As a global centre for biological data, EMBL-EBI hosts the

very large sequence, structure and expression data resources

in Europe as well as eight dedicated research groups. At the

EBI, research is pursued in many different aspects of biology,

exploiting and helping to interpret the biological data held in

the databases. Currently research topics include sequence

analysis, computational genomics, phylogeny, structural

biology, regulatory control networks, functional genomics,

neurobiology and literature/text mining. In addition, research

activities are an important part of several of the large data

resource teams, which also provide services.

We are keen to expand our research into the areas of

comparative genomics, human variation, biomedical

informatics and novel algorithms/statistical approaches,

but will favour outstanding candidates from any area of

computational biology. The candidate will join a strong and

supportive group of research group leaders and will interact

closely with the large database teams, benefiting from their

technical expertise and scientific knowledge.

An initial contract of 5 years will be offered to the successful

candidate. This can be renewed, depending on circumstances

at the time of review.

Further information on the position can be obtained from the

Director of the EMBL-EBI Janet Thornton (doffice@ebi.ac.uk).

To apply, please email a cover letter, CV (in English), three

written references and a concise description of research

interests and future plans quoting ref. no. S/09/052/EBI in

the subject line, to: applications@ebi.ac.uk

EMBL is an inclusive, equal opportunity employer offering

attractive conditions and benefits appropriate to an

international research organisation.

www.embl.org

www.ebi.ac.uk

Part of the European Molecular Biology Laboratory (EMBL), theEuropean Bioinformatics Institute (EBI) is located on the WellcomeTrust Genome Campus at Hinxton, near Cambridge and providescutting-edge research, service and training in the field of bioinformatics.The EBI is a vibrant and multicultural science institute, includingaccess to outstanding students and post-doctoral scientists from aroundEurope and highly developed computational facilities and support.

EMBL-EBI

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Focus on Cambridge/Oxford/London

By importing skills from outside, this program is attempting

to make up for the perceived deficit of entrepreneurial skills and

business knowledge inside universities. But universities are

also offering courses in entrepreneurship to their researchers.

A leading example is Imperial College’s Entrepreneurship Hub,

which teaches all science and technology undergraduates

entrepreneurship skills and provides training for faculty and

researchers in venture creation.

The Push to Translational Research

In medicine in particular, there is a push to create a translational

research chain from laboratory bench, through drug discovery and

development, and into the clinic. This new direction is prompting the

major reorganization of the leading medical schools and teaching

hospitals at Imperial College, UCL, and Cambridge, among others.

The aim is to create American-style academic health science centers,

such as that at Harvard, that integrate research, education, and

clinical care.

Alongside this large-scale restructuring are programs to fill in continued »

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the gaps in the translational research chain. For example, Imperial

College and King’s College London recently won funding for an

Integrative Mammalian Biology program, in which researchers will

be trained in the use of computer models of human physiology to

replace the use of animals in experiments.

One step that exemplifies how the pressure to translate research

through to the market is forcing the pace of multidisciplinary

research is the formation in April of the Center for Stem Cells and

Regenerative Medicine at UCL. The list of specialties that will be

brought together is deep and broad: beyond a swathe of biological

sciences,theyincludephysicalscientists,chemists,mathematicians,

engineers, and material scientists from 130 research groups in

several faculties, hospitals, and research institutes.

Professor Claudio Stern, chair of the center’s steering committee,

says UCL has many scientists in the field of stem cells, but they

were working in relative isolation from each other. “The enhanced

communicationwill greatly improve the flowof information between

basic and clinical scientists that is absolutely crucial for this field to

move forward.”

Featured Participants

Alizymewww.alizyme.com

Astex Therapeuticswww.astex-therapeutics.com

Biotechnology and Biological Sciences Research Councilwww.bbsrc.ac.uk

Bluewater Biowww.bluewater.bio.com

Cambridge Universitywww.cam.ac.uk

Cancer Research UKwww.cancerresearchuk.org

Diamond Light Sourcewww.diamond.ac.uk

GlaxoSmithKlinewww.gsk.com

Heidrick and Struggleswww.heidrick.com

Imperial Collegewww.imperial.ac.uk

King’s College Londonwww.kcl.ac.uk

National Institute for Health and Clinical Excellencewww.nice.org.uk

Oxford Universitywww.ox.ac.uk

Pfizerwww.pfizer.com

Silence Therapeuticswww.silence-therapeutics.com

Summit Corporationwww.summitplc.com

TMO Renewableswww.tmo-group.com

UK BioIndustry Associationwww.bioindustry.org

University College Londonwww.ucl.ac.uk

Wyethwww.wyeth.com

Xentionwww.xention.com

Cambridge London Oxford

Postdoctoral Fellow – Computational GenomicsSalary range £28,000 to £34,433 per annum dependent on experience

TheWellcome Trust Sanger Institute is a world leader in genomic research, with an expanding scientific programme dedicated to under-standing gene function in health and disease.

A post-doctoral bioinformatician is sought for a cutting edge research programme in the Cancer Genome Project. The fellow will focuson the application of new sequencing technologies to identify genetic variants in cancer genomes, including the development of novelalgorithms for sequence analysis and mutation calling, informatic analysis of mutational patterns and cancer gene identification.

Essential Skills:

• PhD which includes a substantial component in bioinformatics or computer science (or equivalent experience).• Experience in the analysis and manipulation of large datasets, such as accessing data via MySQL or commonly usedbioinformatics APIs.

• Proven record of writing analysis programs and scripts to rapidly investigate scientific questions• Ability to work independently to carry out data analysis• Excellent attention to detail and good communication skills

Ideal Skills:

• Interest/previous experience in genomic analysis

Other information: TheWellcome Trust Sanger Institute operates at the forefront of genomics, sequencing and analyses of a wide rangeof genomes from single cell pathogens to higher vertebrates, with an emphasis on genomes relevant to human medicine and welfare.The Cancer Genome Project at the Institute has led the way in the systematic analysis of cancer genomes by using the human genomesequence and high throughput mutation detection techniques to identify somatically acquired sequence variants/mutations and henceidentify genes critical in the development of human cancers. The ideal candidate would be from a programming background interestedin applying their knowledge in the field of genomics. They will be able to work independently, enjoy collaborating with different teams,assimilate tasks easily and generate scripts quickly to analyse genomic data whilst supporting the research of the team and producingpublications.

Benefits: Salary range £28,000 to £34,433 per annum dependent on experience. The Institute has excellent purpose built facilities on theGenome Campus, Hinxton on the outskirts of Cambridge. We offer a comprehensive range of benefits including a final salary pensionscheme and excellent on-site facilities. Further details can be found on our website https://jobs.sanger.ac.uk.

This is a fixed-term contract for 3 years. To submit your CV and apply for this jobplease go to https://jobs.sanger.ac.uk, to register and apply on line.

Research Associate –

influenza research

The Pathogen Evolution Group

LoT applies*

£27,183-£35,469 per annum

We invite applications for a postdoctoral Research Associate to

work in the Department of Zoology, University of Cambridge, UK,

on the development of new analytical techniques for quantifying

the evolutionary selection pressures on influenza viruses. We aim to

better understand their evolutionary dynamics and to inform control

strategies. The project, which is funded by the Human Frontier

Science Program, is start as soon as possible.

The candidate should have a PhD in computational biology, computer

science, virology, epidemiology, a related subject or equivalent and

should have excellent programming skills in C++, Python, Java or

Lisp and ideally other languages.

*The appointment will be for a period of up two years in the

first instance.

Informal email enquiries may be made to Prof. Derek Smith at

am688@cam.ac.uk

To apply see:

http://www.zoo.cam.ac.uk/zooone/administration/vacancy.html

Please quote reference: PF05226.

Closing date: Friday 31 July 2009.

Interviews as soon as possible thereafter.

The University is committed to Equality of Opportunity.

A world of opportunities

www.cam.ac.uk/jobs/

Sir William Dunn School of Pathology

Graduate Research AssistantGrade 6 £25,623 - £30,594 paWe are seeking to appoint a Research Assistant in the laboratory ofProfessor Elizabeth Robertson, FRS, WT-PRF, located at the Sir WilliamDunn School of Pathology.

The post-holder must have a good first degree or equivalent andlaboratory experience in animal models, molecular biology, and/or tissueculture. You should have a keen interest in developmental biology andimmunology. We are seeking an enthusiastic and highly motivatedscientist with good organisational and communication skills to be activelyinvolved in research projects.

Please quote reference LR/09/013.

Post-Doctoral Research AssistantGrade 7 28,839 - £35,469 paWe are seeking to appoint a post-doctoral Research Associate in a WellcomeTrust funded laboratory with research interests in mammalian developmentalbiology located at the Sir William Dunn School of Pathology.

Under the direction of Professor Elizabeth Robertson FRS, WT-PRF, theprogramme focuses on defining the molecular cues responsible for cellallocation and tissue morphogenesis in the developing mammalianembryo. We have exploited transgenic and ES cell technologies toinvestigate the key signalling pathways and transcriptional networks thatregulate expansion of diverse progenitor cell populations. Candidateswith experience in gene targeting construct design, high resolutionimaging, cell sorting, microarrays, CHIP, and/or proteomic approacheswould be especially welcome. We are seeking a well trained andambitious scientist with good organisational and communication skills.

Please quote reference LR/09/014.

Please send your CV and the contact details of three references to theAdministrator, Sir William Dunn School of Pathology, South Parks Road,Oxford OX1 3RE, or email administration@path.ox.ac.uk.

Informal enquiries welcome - please email Prof Robertson atelizabeth.robertson@path.ox.ac.uk (www.path.ox.ac.uk/dirsci).

The closing date is Friday 24 July 2009.

Committed to equality and valuing diversity

www.ox.ac.uk/jobs

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Focus on Cambridge/Oxford/London

The immediate payoff was a commercialization deal in age-related

macular degeneration in which Pfizer became the first big pharma

company to make a move into the use of embryonic stem cells as the

basis for a tissue regeneration therapy.

The Triple Whammy: Multidisciplinarity,

Translation, Commercialization

So how are these huge shifts in the research firmament—multidis-

ciplinarity, translational research, and commercialization—affecting

one of the largest funders of basic biomedical science in the country,

Cancer Research UK?

“We are not turning away from basic research—that is still at

the core of what we do,” says Simon Vincent, the charity’s head of

personal awards. However, he adds, “The nature of basic science is

changing, and this is influencing the kind of people we are looking

to recruit.”

In particular, the charity is moving up the development pathway,

and has begun to establish drug discovery and development

capabilities. “This means we are recruiting more synthetic chemists,

for example,” says Vincent.

Indeed, in thismovetosecurethefoundationsofdrugdevelopment,

CRUK has needed to bridge several skills gaps. An example is

bioinformatics, a specialty inwhich it has set up groups in Cambridge

and London. “This is a reflection of the impact of genomics on the

way we do basic biology,” Vincent says.

In November 2008 CRUK announced its GBP1.5 billion science

strategy for 2009–2014, under which it will establish 20 centers of

excellence linking research, patient care, public engagement, and

prevention. “We are putting more emphasis on translation—that is

our clear objective. We will only work with universities to establish

a center if there is a commitment from academic groups and clinical

departments to get involved,” explains Vincent.

The centers will not require new specializations, but Vincent says

therewill be a need to cultivate researcherswho are capable of seeing

patients in the clinic and then applying their observations in the lab.

Speaking in March, Vincent said CRUK was actively recruiting, and

there was no sign as yet of an increase in applications as a result of

fallout from the pharma and biotech sector.

However, as a charity, CRUK is seeing a fall in donations as the

economy contracts, Vincent says. “It has had an impact; we are ex-

pecting a 4 percent fall this year. But we are not cutting programs.”

Cleantech: A New Source of Science JobsThe sudden contraction in some parts of the science jobs market

may undermine existing career plans of those in pharma and biotech

and require a rethink by new graduates trying to get on the first

rung of the ladder. But avenues are opening up elsewhere. The

UK’s emerging cleantech sector holds prospects for people with

pharmaceutical experience, according to Hamish Curran CEO of TMO

Renewables, a cellulosic biofuels specialist. “We’ve been recruiting

over the past two years, and when I look at our ranks, about one-

third of staff are from the pharmaceutical sector.”

The company was founded in 2002 to develop second generation

biofuels and is currently testing its first demonstration plant. Curran,

himself a veteran of the oil industry, advises that cleantech projects

require a new mix of skills. “There has to be a marriage between

engineering and biology to build a bioprocess plant that can operate

24 hours a day.”

Similarly, sustaining microbial populations is central to the R&D

activity of Bluewater Bio, a wastewater treatment specialist. The

London-based company is in the process of optimizing technology

discovered in South Korea for removing organic material from

wastewater, to suit environmental conditions and wastewater

standards in the UK and elsewhere in Europe. “We have a formula,

but we need to understand more about the effects of changing

the operating parameters on the process,” says Garry Hoyland,

technical director.

There is increasing public investment in the field, too. A notable

example is the GBP27 million Sustainable Bioenergy Centre set up

with the aim of replacing petrol with biofuels. In another initiative the

BBSRC has joined with 10 companies to develop the technologies

required to replace petrochemicals through biorefining.

Potential recruits should be aware that cleantech is opening up a

new interface between disciplines, says Tim Barnes, executive direc-

tor of UCL Advances, the technology transfer and commercialization

arm of University College London. This is reflected in the kinds of

expertise that employers of science graduates are looking for. “Just

look at the problems we are trying to solve: developing a hydrogen-

powered car covers a range of different disciplines—many aspects of

which aren’t really to do with engineering,” says Barnes. Those inter-

ested in working in the field need to demonstrate they can network

and operate across disciplinary barriers.

Traditionally 25 percent of the UCL’s numerate graduates have

gone to work in the City of London’s financial services sector, a

market that has dried up overnight. “Science graduates at any level

are finding it tough to get jobs,” says Barnes who advises that one

tack is to complete another course.

The university is helping by offering discounts on fees for its

postgraduate courses. As well as increasing skills levels, it hopes

that the best students will be attracted into research.

This would be at least one positive outcome of the current finan-

cial crisis.

Nuala Moran is a freelance writer based in Cheshire, United

Kingdom.

DOI: 10.1126/science.opms.r0900073

“We’ve been recruiting

over the past two years,

and when I look at our

ranks, about one-third of

staff are from the pharma-

ceutical sector.”

—Hamish Curran

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Cambridge

Postdoctoral Scientist£25,622 - £27,223 per annum

We are seeking a Postdoctoral Scientist to work in the Group ofDr Ingo Greger, to investigate signalling properties of neuronal andrecombinant AMPA-type glutamate receptors.The project will involve analysisof native AMPA receptors from hippocampus, as well as assaying recombinant,structure-guided receptor mutants in heterologous expression systems.

Applicants should have a PhD in biological and/or physical sciences,and experience in electrophysiological recording techniques applied toligand-gated ion channels. A strong interest in synaptic signalling andion-channel function is essential. A background in calcium imaging techniqueswould be advantageous.

You will be awarded an MRC Career Development Fellowship, which is athree year training and development position for a postdoctoral scientistwho has recently completed their doctoral studies or is moving into anew research discipline.

Your salary is supported by a flexible pay and reward policy, 30 days’annual leave entitlement, an optional MRC final salary pension schemeand excellent on site sports and social facilities.

This position is subject to pre-employment screening.

Applications for this role must now be made online athttp://jobs.mrc.ac.uk inputting reference LMB09/257. If you donot have internet access or experience technical difficultiesplease call 01793 301280.

Closing date: 23 July 2009.

For further information about the MRC please visit www.mrc.ac.uk

The Medical Research Council is an Equal Opportunities Employer

New Faculty and post-doctoral

appointments in The University

of Queensland

Centre for Advanced Imaging (CAI) in

Brisbane, Australia

caicentre for advanced imaging

Department of Veterans Affairs

Office of Research and Development

Biomedical Laboratory Researchand Development Service

2008 William S. Middleton Award

Was presented to:Stephen G. Waxman, M.D., Ph.D.

VAConnecticut Healthcare System, West Haven, CT

TheMiddletonAward is Biomedical Laboratory Research andDevelopment Service’s highest scientific honor, awarded annu-ally to a senior VA investigator for accomplishments in areasof prime importance to the VA’s research mission.

Dr. Waxman was especially honored for his contributions toour understanding of the causes and treatment of neurologi-cal disorders including spinal cord injury, multiple sclerosisand chronic neuropathic pain. The award also recognizes hisexemplary record of service to the VA and to the biomedicalprofession.

ANNOUNCEMENTS

FOCUS ON CAMBRIDGE/OXFORD/LONDON

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Associate or Full Professor

The Institute of Human Virology (IHV) and the Institute for Genome Sciences (IGS), in conjunctionwith the Marlene and Stewart Greenebaum Cancer Center at the University of Maryland School ofMedicine, are searching for a faculty candidate to direct a new Division of Oncological Genomics. Thenew division will be located in the IHV and, coupled with full appointments in IHV and IGS, will havethe ability to recruit junior faculty to support its mission. The appointment will be either at theAssociateor Full Professor level, commensurate with experience.

The successful candidate will have extramural funding and a track record of conducting independent andcollaborative research using approaches that include genomics and bioinformatics, as well as an interestin the field of cancer. The candidate will work closely with tumor cell biologists, molecular biologists,immunologists, and epidemiologists in the IHV to identify high-risk individuals and cancers that mayhave an infectious etiology. Particular emphasis will be placed on cancer associated with adventitiousagents, especially viruses, and the candidate will use appropriate genomics and bioinformatics approachesto identify such agents in tumors, in the tumor microenvironment, and in individuals at high risk forspecific cancers. The qualified individual will have publications utilizing genomics that may be appli-cable to human cancer. The cancers of interest in this institute are those occurring in the context of HIVor Hepatitis C infection and include cancer of the lung, kidney, liver, ovary, prostate, brain, leukemia,lymphoma and epithelial cells. The qualified individual will have familiarity with genomic applicationssuch as transcriptional profiling, genotyping, tiling arrays, exon throughput assays, methylation, real timePCR, microRNA analyses and automated high throughput assays, and be aware of technology leadingto detection of other agents, including possibly novel ones.

IHV and IGS offer excellent laboratory facilities, competitive salary and startup packages, and accessto numerous resources within the School of Medicine, including state-of-the-art BSL3/ABSL3 facilitiesand a large-scale DNA sequencing and analysis core in a strong academic environment.

The faculty search committee will be co-chaired by Dr. Robert Gallo, Director of IHV, and Dr. ClaireFraser-Liggett, Director of IGS.

Please submit a letter of interest, CV, and three references to: Oncologic Genomics Faculty SearchCommittee, c/o Beth Peterson, Institute of Human Virology, 725 West Lombard Street, S307,

Baltimore, MD 21201; bpeterson@ihv.umaryland.edu.

The University of Maryland, Baltimore is an Equal Opportunity, Affirmative Action Employer.Minorities, women, veterans and individuals with disabilities are encouraged to apply.

Clinical Chair inTranslational MedicineNorwichThe University of East Anglia (UEA) is an internationally renowned campus based university that provides topquality academic, social and cultural facilities to over 13,000 students. The School of Medicine was established in2000 and with its strong links with the Norfolk and Norwich University Hospitals NHS Foundation Trust, Institute ofFood Research and John Innes Centre, has an impressive track record of internationally recognised research and ofattracting substantial research funding. UEA is now seeking to appoint an exceptional clinical scientist to the newpost of Clinical Chair in Translational Medicine. The successful candidate will join established groupings of bothlaboratory and social researchers with access to state of the art facilities both at the University and on the hospitalsite. This is a hugely exciting opportunity to play a major role in shaping the clinical research undertaken acrossthe whole of the Faculty of Health over the coming decade.

For further information and a candidate brief containing application details please see www.odgers.com/25956 orcontact us quoting reference CS/25956S. Closing date for applications is 17th July.

The Role:• To contribute to the clinical research strategy and the

expansion of postgraduate research.

• To develop and lead a programme of high calibre researchin an area related to the School of Medicine’s currentresearch strengths.

• To develop external relationships with basic scientists inthe Faculty’s partner organisations and encouragecollaborative working with the Trust to increase thenumber of clinically active academics.

The Candidate:• An exceptional clinical academic with an active research

profile of distinction and a track record of peer reviewedand published papers and of securing external funding.

• Strong intellect and commitment to innovation; s/he willbe a visionary and strategic thinker, able to spotopportunities and assess risks.

• Well developed leadership skills with a commitment to thefacilitation of clinical/translational research within anintegrated academic-clinical unit.

11 Hanover Square,

London W1S 1JJ

0845 1309005

www.odgersberndtson.co.uk

Executive Search

51 offices in 24 countries

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www.merckcareers.jobs/SCIENCE

At Merck, we believe in putting patients first

in all we do. This commitment, along with

our focus on developing novel medicines and

vaccines that address unmet patient needs,

distinguishes us as one of the world s leading

research-driven pharmaceutical companies.

Our Basic Research Biology teams are

therapeutic area based teams supporting

target identification biology, In Vitro target

validation, disease-relevant cellular biology,

compound mechanism of action studies, and

target-related safety and toxicity. Successful

candidates will engage in drug discovery and

basic research efforts with a focus in biology.

To be considered for any of these

opportunities, please visit our career site at

www.merckcareers.jobs/SCIENCE to create

a profile and submit your resume for any of

the open positions that may be of interest.

To view these opportunities, please visit our

career site and search under keywords: BRB.

Merck is an equal opportunity employer,

of its manifestations.

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Brain and spinal cord research Institute (Paris-France), international institute of neurosciences,recruits

Junior and Senior group leaders

The ICM, will open in the Pitié-Salpétrière universityhospital in Autumn 2010. The institute - 22 000 sqm -will host 600 researchers, cutting edge cores facilities, aneuroimaging platform (MRI 3T, MRI 7T, animal MRI11.7 T), a large clinical research center, animal housingand a biotechnological spin off companies area.

The scientific program aims at developing multidisci-plinary research projects of excellence with an emphasison the discovery of new treatments for diseases of thenervous system.

Deadline: September 5, 2009

Further information and application file on:http://www.icm-institute.org/job

Faculty Positions in Biomaterials and Engineering

Soochow University, founded in 1900 in Suzhou, Jiangsu Province, is apremier university in China. The University is committed to excellence ineducation, research and innovation.Amajor expansion of itsmultidisciplinaryresearch programs is underway acrossmany scientific areas including physics,chemistry, materials sciences, textile engineering and design, life sciences,and medicine. A complete listing of open positions is available at http://rsc.suda.edu.cn/zpxx.asp?type=15.

The National Engineering Lab for Silk Exploration Research and Innovation(NELab SERI), SoochowUniversity, invites applications for faculty positionsat the levels of Associate and Full Professors in the following areas:Bio/Functional Materials; Mesoscopic and Nano Materials and Devices;Computational Biophysics; Biosensor and Bioelectronics; Imaging andSpectroscopy Techniques; Textile Engineering and Design; Bio/MedicalChemistry; Synthetic and Supramolecular Chemistry; Surface Sciencesand Optics.

Candidates should have a Ph.D. with an outstanding track record, anddemonstrate a strong commitment to excel in research and teaching in theabove areas. They should possess leadership qualities and are expected toestablish their respective research strengths in the Lab. Candidates withoutstanding potential and promise will also be considered even if their fieldsof specialization do not fall within any of the above categories. Successfulcandidates will be provided with competitive relocation and salary packages,generous start-up funds, and state-of-the-art research facilities.

The recruitment will start immediately and continue until all the vacanciesare filled. Outstanding individuals should send their detailed curriculumvitae, a brief research plan and a statement of research interests, and fullnames and contacts of three referees to: Mr. Zhen Li, HR Department,SoochowUniversity, Box 428, 50DonghuanRd, Suzhou, Jiangsu, 215021,

China; Email: sdrcjl@suda.edu.cn; Tel: 86-512-67503045; Fax: 86-512-

67503248; http://www.suda.edu.cn/.

SOOCHOW UNIVERSITY

Associate Director for Basic ScienceUniversity of Illinois at Chicago Cancer Center

The University of Illinois at Chicago (UIC) Cancer Center is recruiting an outstandingcancer scientist for the key senior leadership position of Associate Director for BasicScience. He/she will have the opportunity to continue to pursue individual laboratoryinterests while providing scientific direction and guidance to the center’s threerobust basic science programs: carcinogenesis and chemoprevention, experimentaltherapeutics and imaging, and tumor cell biology.

This administrative position (25%) reports directly to the UIC Cancer Center Directorand will play a key role in shaping the center’s scientific direction and achievingits overall goals, including building cancer translational research. He/she will workclosely with the associate directors for clinical science and for cancer control andpopulation science.

Specific administrative responsibilities include: i) oversight of intra and inter researchprogram interactions and collaborations; ii) developing program focus, its evaluationand enhancement; iii) guiding and influencing recruitment of new investigators;iv) resource allocation; v) oversight for cancer center basic science sharedresources; and vi) involvement in preparing an application for an NCI Cancer CenterSupport Grant.

Significant institutional resources are available to support this leadership position(dedicated laboratory space, pilot project funds, salary and start-up funds).

The successful candidate must have a PhD and/or MD with a minimum of sevenyears of cancer research experience, including evidence of substantial scholarlycontributions and active, consistent peer-reviewed cancer research funding. Strongleadership, interpersonal, and communication skills are required to advanceinterdisciplinary and translational cancer research among cancer investigators in thesix health science colleges that contribute to the cancer center.

Some administrative experience in an NCI-designated cancer center, an interest intranslational cancer research, and a global perspective on cancer research are alsodesirable.

Academic rank will be determined based on the candidate’s credentials andexperience. An academic department appointment will be in the most appropriatehealth science college.

For fullest consideration, submita cover letter, resume and three(3) references by July 15, 2009 to:jsylvest@uic.edu. UIC is an AA/EOE.

EXPERIMENTAL PATHOLOGY FACULTY POSITIONS

The Department of Pathology and Laboratory Medicine of theWeill CornellMedical College invites applications for faculty positions in experimentalpathology. Candidates are expected to develop and maintain productive,independent, externally funded research programs in basic mechanisms ofhuman disease which fall within the broad areas of molecular oncology andcancer genetics.

Candidates may hold an MD, a PhD, or combined MD and PhD degreesbut must possess a sufficient amount of post-doctoral research training todevelop an independent research program. Teaching responsibilities willinclude graduate and medical students.

The Department offers a supportive intellectual environment in which severalmid-level and senior scientists direct well-funded independent research pro-grams inmolecular oncology, immunobiology, and vascular biology.Modernresearch laboratory facilities, excellent core facilities, and competitive start-uppackages are available.

Interested applicants should submit a curriculum vitae, representative recentpublications, and a brief description of past scientific accomplishments, futureresearch plans, and career objectives, as well as the names of three individualsfamiliar with the applicant and the applicant’s research program. Applica-tions will be accepted until all positions are filled. Please submit via emailto rubinma@med.cornell.edu or to:

Dr. Mark A. Rubin

Vice Chairman for Experimental Pathology

Department of Pathology and Laboratory Medicine

Weill Cornell Medical College

1300 York Avenue, Box #69

New York, New York 10065

Weill Cornell Medical College is an Equal Opportunity/Affirmative ActionEmployer. Women and minority candidates are encouraged to apply.

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Professorial appointment

in Neuro Imaging

Queensland Brain Institute (QBI) and the Centre for

Advanced Imaging (CAI) in Brisbane, Australia

caicentre for advanced imaging

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www.covancecareers.com/biomarkers

Diversity within Covance is alive and universal. EOE

Covance,oneof theworld’s largestandmostcomprehensive

drug development services companies is currently creating

a global Biomarker Center of Excellence in our Greenfield,

IN location. This center of excellence will drive our holistic

approach through the entire spectrum of drug development –

from the biomarker and therapeutic perspective.

We are seeking Biomarker professionals at various levels to

drive solutions for clients across Covance’s varied service

offerings. We have multiple positions available, including:

Sr. Scientist, Biomarkers (Req# 17139)

A PhD in physical or biological science is required focusing

on Oncology, Neuroscience, Immunology or Metabolic

Diseases.

For information on all Biomarker positions, please visit:

www.covancecareers.com/biomarkers or email:

covance.jobs@covance.com.

BIOMARKER CENTER

OF EXCELLENCE

LOOKING FOR THE BEST AND

THE BRIGHTEST

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• Job Postings

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www.sciencecareers.org

Get help

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experts.

Positions for Immunologist and Molecular BiologistThe “Chantal Biya” International Reference Centre for HIV/AIDSResearch on Prevention andTreatment(CIRCB) is located in Yaounde, the capital city of Cameroon, Central Africa.

The mission of CIRCB is to carry out clinical research, prevention and surveillance of HIV infection/AIDS and related infections as a contribution to the global AIDS response. At CIRCB, the Immunol-ogy, Microbiology and Molecular Biology, Bioinformatics and Clinical laboratories provide a researchenvironment that is collaborative and highly conducive to advancing clinical and applied research. TheCentre is equipped with a DNA analyzer, FacsCalibur, ELISPOT chain, fully-automated Biochemistryanalyzer, Haematology analyzer and Leukocyte Differential Counter.

CIRCB is seeking candidates (mid-level or senior scientist) for two full-time positions. They are: (1)Immunologist: candidate should be holder of a doctoral degree (Ph.D., MD or MD/Ph.D.) or equivalentexperience in Immunology, with specialized skills in flow cytometry, cell culture and ELISPOT. (2)Molecular Biologist: candidate should be holder of a doctoral degree, (Ph.D., MD or MD/Ph.D.) orequivalent experience in molecular biology with experience in high-throughput DNA sequencing.

The candidate should have a documented history of research success with a minimum of five yearspost-doctoral experience, a good track record of publications, and the ability to work independently andsupervise his/her technicians and mentor junior investigators. Salary: a competitive salary and benefitspackage will be commensurate with qualifications and experience. These positions are available for threeto five years on a renewable contract.

Cameroonians and otherAfrican scientists working abroad are encouraged to apply. Interested candidatesshould send their curriculum vitae, a two-page statement of research interest covering past accomplish-ments, current and planned research goals, complete bibliography, names and addresses of three refereesto:Pierre Joseph FOUDA, MD, Director

OrJudith Ndongo TORIMIRO, Ph.D.

Chief, Scientific Secretariat

B.P. 3077, Yaounde, Cameroon

Telephone/Fax: (+237) 2231-5456

Email : scientific.circb@yahoo.com

CIRCBCENTRE INTERNATIONAL DE RÉFÉRENCE “CHANTAL BIYA”POUR LA RECHERCHE SUR LA PRÉVENTION ET LA PRISE EN CHARGEDU VIH/SIDA

Photo of CIRCB

FACULTY POSITIONS

SANFORD CHILDREN’S HEALTH RESEARCH CENTER

Sanford Children’s Health Research Center (SCHRC) invites applications from researchers for full time facultypositions within Sanford Research USD and the Department of Pediatrics of the Sanford School of Medicine ofThe University of South Dakota. An historic $400 million gift by philanthropist T. Denny Sanford has allowedfor expansion of Sanford Research USD and dynamic development of programs focused on children’s health. Anadditional donation by Mr. Sanford has led to the creation of a two-campus Sanford Children’s Health Research

Center: at the Burnham Institute for Medical Research in La Jolla, California and Sanford Research USD in Sioux Falls, South Dakota. The collabora-tion between the two locations will establish the basis of an integrated, world class, academic pediatric research network. In addition, SCHRC Facultywill also collaborate with the Sanford Project that centers research on Juvenile Diabetes, the Cardiovascular Health Research Center, the Cancer BiologyResearch Center and the Health Disparities Research Center at Sanford Research USD.

We seek outstanding scientists of any rank with a research interest that focuses on any area of children’s health and disease. Areas of interest include, butare not limited to, genetics, developmental biology and the biological basis of disease. Candidates will be expected to develop an independent extramuralresearch program and complement the energetic interdisciplinary and collaborative nature of the growing SCHRC. Successful candidates will have aPhD and/or MD degrees.

Significant institutional support including laboratory space and research support will be offered. In addition, a comprehensive compensation packagewill be tailored to the individual’s qualifications.

Applications should include a detailed curriculum vitae, a description of research experience and future plans, and the names and contact informationfor at least three references. Application materials should be sent to:

Dr. David A Pearce

Director, Sanford Children’s Health Research Center

Sanford Research USD

Professor, Department of Pediatrics

Sanford School of Medicine of The University of South Dakota

1305 W. 18th St., PO Box 5039

Sioux Falls, SD 57117-5039

Telephone: 605-333-6447 FAX: 605-328-6951

Email: pearced@sanfordhealth.org

Sanford Health is an Equal Opportunity/Affirmative Action Employer.

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POSITIONS OPEN

The Department of Radiation Oncology at theWashington University School of Medicine in SaintLouis, Missouri, seeks qualified applicants for theposition of DIRECTOR, CANCER BIOLOGYDIVISION. The position is a tenure-track facultyappointment at the rank of ASSOCIATE or FULLPROFESSOR. Successful candidates must demonstratesignificant experience in developmental therapeutics incancer research and will be expected to establish aninnovative research program, provide education andmentorship, and participate in service activities withinthe medical school at the senior leadership level.Applicants should forward a cover letter, curricu-

lum vitae, three references, and a description of re-search to:

Dennis E. Hallahan, M.D.Elizabeth H. and James S. McDonnell III

Distinguished Professor and Department HeadDepartment of Radiation Oncology

4511 Forest Park Boulevard, Suite 200St. Louis, Missouri 63108

HARVARD UNIVERSITY. The Department ofPsychology anticipates making one tenure-track ap-pointment at the ASSISTANT PROFESSOR levelto begin July 1, 2010. The Department conducts ex-perimental research in several areas, including cogni-tion, brain, and behavior; psychopathology and clinicalpsychology; developmental psychology; and socialpsychology. Faculty and students in the Departmenthave access to a recently opened state-of-the-art brainimaging facility located nearby the Department.We are particularly interested in individuals who are

working in the areas of judgment and decision making/neuroeconomics, developmental cognitive neuroscience,or human behavioral genetics/brain genomics.Candidates should expect to have completed the re-

quirements for the Ph.D. prior to appointment and tohave demonstrated a promise of excellence in both re-search and teaching. Teaching duties will include offer-ings at both undergraduate and graduate levels.Candidates should submit curriculum vitae and

representative reprints and should have at least threeletters of recommendation sent to: Psychology SearchCommittee, Harvard University, Department ofPsychology, WJH 230, 33 Kirkland Street, Cam-bridge, MA 02138. The closing date for applying isOctober 1, 2009.

Applications from women and members of minority groupsare strongly encouraged. Harvard University is an AffirmativeAction/Equal Opportunity Employer.

POSTDOCTORAL POSITION available imme-diately to study the molecular mechanisms of T lineagedevelopment and transformation using both zebrafishand murine models. Available projects include: (1)executing a zebrafish genetic screen to identify genescontrolling T cell development and transformation;(2) understanding the basis for blockade of T celldevelopment by ribosomal protein L22 deficiency(Immunity 26:759-772, 2007); or (3) investigatingthe role of signal strength in ab/gd lineage commit-ment (Immunity 22:595-606, 2005). Experience inprotein-RNA interactions and/or zebrafish geneticsdesirable but not essential. The successful applicantwill enjoy a competitive salary and will have access tosubsidized housing and child care as well as an activepostdoctoral association. Curriculum vitae and threereferences should be sent to: David L. Wiest, Ph.D.,Fox Chase Cancer Center, 333 Cottman Avenue,Philadelphia, PA 19111-2497. Fax: 215-728-2412. E-mail: david.wiest@fccc.edu. Equal OpportunityEmployer.

International Programme for Advanced Study on theEnvironment and Climate

Istituto Nazionale di Geofisica e Vulcanologia(www.ingv.it)

Centro Euro-Mediterraneo per i Cambiamenti Climatici(www.cmcc.it)

The International Programme forAdvanced Study on the Environment and Climate (PISAC)of the Istituto Nazionale di Geofisica e Vulcanologia (INGV) is currently seeking applicationsfrom distinguished scholars for visitor positions, from 6 months up to 12 months. Seniorand junior positions are available depending on qualifications.

The PISAC is an interdisciplinary effort focusing on climate change issues from a scien-tific, historical and socioeconomic perspective. The Program is carried out in cooperationwith the Centro Euro-Mediterraneo per i Cambiamenti Climatici (CMCC). The CMCC isan Italian Research Consortium consisting of several Italian public and private researchinstitutions involved in climate-related research, including INGV. Research objectives ofCMCC include investigating climate variability and climate change by developing and usingmodels of the Earth System.

Interested individuals are expected to have documented experience in climate researchand being motivated to share their expertise and to interact with local scientists. They willbenefit from the high performance computing facility and the Earth System Models avail-able to CMCC. Possible research themes include process studies on climate variabilityand change from seasonal to decadal to century timescales, the carbon cycle, atmosphericchemistry, and ocean data assimilation. Individuals seeking a location for a sabbaticalwould be suitable applicants.

This is an open call. Applications will be evaluated quarterly. The next deadlines are: 31August 2009, 30 November 2009, 28 February 2010, and 31May 2010. In your application,please include a curriculum vitae and a brief research proposal.

Please send your application by email to :Loredana Amato, email : amato@bo.ingv.itINGV - Viale Aldo Moro 4440127 Bologna, Italy

“The premier food and agricultural research agency of USDA”

ASSISTANT AREA DIRECTOR

(Agricultural Administrator, GS-0401-15)

Pacific West Area Salary Range of $131,873.00 to $153,200.00Midwest Area Salary Range of $111,760.00 to $145,290.00

Applications must be received by July 21, 2009

The USDA, Agricultural Research Service (ARS) is seeking highly qualified candidates for twopermanent full-time leadership positions of Assistant Director for the Pacific West and MidwestAreas, located in Albany, California and Peoria, Illinois, respectively. The Assistant Director is akey member of a Senior Management Team that:• Implements problem-solving research that provides an abundant, nutritious and safe food supply,protects the environment, and generates sustainable bioproducts and biofuels.

• Leads a large, talented cadre of scientists in an eight-state region.• Works collaboratively with scientists and administrators within ARS, the Land-Grant Universi-ties, State Agricultural Experiment Stations, other governmental agencies (Federal, state, local),Non-Governmental Organizations, private industry, and other stakeholder groups in the region,nation, and around the world.

• Manages human, fiscal and physical resources.

Candidates seeking a challenging leadership position that contributes to a secure and sustainableagricultural future are encouraged to apply.Applicants must have professional knowledge of researchmethods related to the biological sciences, environmental sciences, agricultural engineering, foodtechnology or chemistry; knowledge of cooperative and user oriented programs directed towardagricultural research; and excellent leadership and communication skills.

Join us in Advancing the Health and Wealth of the Nation and Its Peoples,

Solving Problems, Expanding Knowledge, Delivering Answers

To apply, print a copy of the vacancy announcement from the ARS Careers Website at http://www.ars.usda.gov/Careers/Careers.htm (Pacific West Area - ARS-X9W-0188) or (MidwestArea - ARS-X9W-0194) and follow the application directions provided. For questions about thesepositions, call (510) 559-6015 (Pacific West Area) OR (309) 681-6633 (Midwest Area).

USDA/ARS is an Equal Opportunity Employer and Provider.

www.ars.usda.gov

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Max Planck Research Award 2010The International Research Award of

the Alexander von Humboldt Foundation and the Max Planck SocietyThe Alexander von Humboldt Foundation and the Max Planck Society jointly confer the Max Planck Research Award on exceptionallyhighly-qualified German and foreign scientists. The researchers are expected to have already achieved international recognition andto continue to produce outstanding academic results in international collaboration � not least with the assistance of this award.Funding for the award is provided by the Federal Ministry of Education and Research.

Every year, two research awards are conferred on internationally renowned academics. One of the awards should be given to a re-searcher working in Germany and the other to a researcher working abroad. As a rule, each Max Planck Research Award is endowedwith 750,000 Euros. Nominations of qualified female academics are especially welcome.

On an annually-alternating basis, the call for nominations addresses areas within the natural and engineering sciences, the life sci-ences, and the humanities.

The Max Planck Research Award 2010 will be awarded in the area of life sciences in the field of

Human EvolutionThe Rectors/Presidents and Deans of German universities or research organisations are eligible to nominate candidates. Nominationsmust be submitted by the Rectors/Presidents of the universities or research organisations to the Administrative Headquarters of theMax Planck Society or the Alexander von Humboldt Foundation. Direct applications by candidates themselves are not possible. Thedeadline for nominations is 26 October 2009.

Please find further information at either www.humboldt-foundation.de or www.mpg.de.

Max-Planck-GesellschaftHofgartenstraße 8D-80539 Münchenphone: +49-(0)89-2108-1265Fax: +49-(0)89-2108-2240E-mail: maxplanck-fp@gv.mpg.de

Alexander von Humboldt-StiftungJean-Paul-Straße 12D-53173 Bonnphone: +49-(0)228/833-197Fax: +49-(0)228/833-212E-mail: leilani.orate@avh.de

Call for nominations

CANADA EXCELLENCE RESEARCH

CHAIR IN MICROBIOME RESEARCH

HAMILTON, ONTARIO, CANADA

Farncombe Family Digestive Health Research InstituteFaculty of Health Sciences

McMaster University

THE OPPORTUNITYMcMaster University has been invited to submit an application for a Canada ExcellenceResearch Chair (CERC) in Microbiome Research. The CERC program was created torecognize that Canada's future prosperity depends on its ability to attract the highestcalibre of researchers and scholars to this country. This prestigious program willaward the chairholder and their research teams with up to $10 million over sevenyears to conduct research in areas of strategic importance to Canada. Moreinformation on the CERC program can be found at http://www.cerc.gc.ca/

QUALIFICATIONS OF THE POTENTIAL APPLICANTWe are seeking an internationally recognized expert in the field of the intestinalmicrobiota and probiotics. The successful applicant will work within a large group ofscientists expert in host physiology, immunology and mucosal vaccine development,behavior, diabetes and obesity, and to exploit the therapeutic potential of themicrobiota in these fields. Applicants must have proven expertise in molecularidentification and manipulation of the intestinal microbiota and/or probiotics andmust be full professors, or associate professors who are expected to be promoted tothe full professor level within one or two years as of November 2009. Alternatively, ifthey come from outside the academic sector, applicants must possess the necessaryqualifications to be appointed at these levels.

The closing date for application is August 31, 2009. The selected candidate will beexpected to participate in compiling the final application to the Canadian government(due November 15, 2009). If successful, the start date for the Chair will be July 1,2010 (negotiable), and will be at the rank of Full Professor in the Department ofMedicine.

Qualified applicants should send their Curriculum Vitae to:

John L. Wallace, PhD, MBA, FRSCDirector, Farncombe Family Digestive Health Research Institute

McMaster University1200 Main Street West, HSC-3N9

Hamilton, Ontario, L8N 3Z5, CanadaTel: (+1) 905-525-9140, extension 22591

Fax: (+1) 905-528-9862wallacejohn@mcmaster.ca

http://farncombe.mcmaster.ca

Note: All qualified candidates are encouraged to apply. However, Canadian citizens and permanentresidents will be considered first for these positions. McMaster University is strongly committed toemployment equity within its community, and to recruiting a diverse faculty and staff. The Universityencourages applications from all qualified candidates, including women, members of visibleminorities, Aboriginal peoples, members of sexual minorities and persons with disabilities. N

W182195RM

The 7th Okazaki Biology Conference“The Evolution of Symbiotic Systems”

Kakegawa, Japan, January 11-14, 2010

TheOkazaki Biology Conferences (OBC) hosted by the National Institutefor Basic Biology (NIBB), one of Japan’s leaders in promoting interna-tional cooperation in the field of biology, are international conferencesdedicated to providing opportunities to create new international networksof scientists as well as to facilitate the development of future areas ofresearch in the biological sciences. They accomplish these goals byproviding both a forum for the presentation and discussion of frontierresearch and an opportunity to discuss and map out the future directionof the field with researchers from around the world. The conferences areheld in relaxing intimate settings that allow participants to get the mostout of the time spent.

The theme of the 7th OBCwill be “The Evolution of Symbiotic Systems”.Symbiosis is a biological phenomenon involving dynamic changes of thegenome,metabolism, and signaling network, and a unified comprehensionof these interactions is requiredwhen studying symbiotic organisms. In theConference, we will explore a new direction of the fundamental science“Symbiotic systems” using a great variety of living species and bridgethe gap between scientists studying various examples of these systems.Organized byMasayoshi Kawaguchi (NIBB).

NIBB is calling for speakers to contribute to this conference. Traveling

and lodging expenses will be provided for those selected.

For more information please see the link to the 7th OBC homepagebelow.

Registration Process and Deadline: Please use the link below todownload the application form and email the completed form toobc7@nibb.ac.jp by August 10th, 2009.

National Institute for Basic Biology

TEL: +81 (0)564-55-7596

E-mail: obc7@nibb.ac.jp

URL: http://www.nibb.ac.jp/obc/7th/

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AWARDS

CONFERENCE

POSITIONS OPEN

PH.D. RESEARCH MICROBIOLOGIST

Project description: A Senior Research Microbiol-ogist position is available in the Environmental Sci-ences and Biotechnology Department at the SavannahRiver National Laboratory (website: http://srnl.doe.gov) for an individual with training in molecular mi-crobiology and biogeochemistry. The successful can-didate will join a multidisciplinary team of investigatorswhose primary focus will be the discovery, develop-ment, and implementation of biological processes forthe remediation of organic pollutants, metals, and mixedwastes in soils and groundwater. We are keenly inter-ested in applicants that can combine approaches (e.g.,stable isotope biogeochemistry, fluorescent in situ hy-bridization, microanalytical and imaging technologies,genomics) to elucidate cellular metabolism and eco-physiological adaptations as they pertain to microbialinteractions during detoxification and stabilization ofsoils in contaminated environments.Qualifications: Candidates must have a completed

Ph.D. with postdoctoral experience in microbiology,molecular biology, and biogeochemistry. The success-ful candidate must have a clear ability to obtain fund-ing and maintain a productive research program.How to apply: Qualified applicants are encouraged

to submit a cover letter, detailed curriculum vitae, andreference job number PR-EX-2009-00143 to the SRNLRecruiting Office at e-mail: srnlresearchrecruiting@srnl.doe.gov.

This appointment is open to all qualified U.S. citizens withoutregard to race, color, age, religion, sex, national origin, physical ormental disability, or status as a Vietnam-era veteran or disabledveteran. U.S. Department of Energy security clearance is requiredfor this position.

POSTDOCTORAL POSITION available to studythe molecular mechanism of hepatocyte growth factor–mediated inhibition of lung fibrosis. Experimentalapproach will involve studies of regulation of gene ex-pression by microRNAs in a mouse model of lung fi-brosis and cell culture model of epithelial-mesenchymaltransition. The successful applicant will have the op-portunity to utilize several cutting-edge technologiesusing outstanding core facilities at the University ofPittsburgh School of Medicine. Our laboratory hassignificant collaborations with both basic and clinicalscience departments. Candidates should have experi-ence in molecular biology. Additional experience inmicroarray analysis, lentivirus-mediated gene transfer,or immunofluorescence microscopy is highly desir-able. Strong written and verbal skills in English are es-sential. This research is funded by NIH. Please send abrief cover letter, curriculum vitae, and the names andtelephone numbers of two references to:Dr. Prabir Ray,Department of Medicine/Pulmonary Division, Uni-versity of Pittsburgh School of Medicine, MUH628 NW, 3459 Fifth Avenue, Pittsburgh, PA 15213.E-mail: rayp@pitt.edu; website: http://www.dept-med.pitt.edu/paccm.

POSTDOCTORAL POSITION (100 percent,multiyear) in mouse genetics and neurodegenerativedisease available immediately at University of Califor-nia, Davis to use mouse models to study the genetic,cellular, molecular, and mitochondrial mechanisms ofneurodegenerative disease. Expertise in cloning, con-ditional knockouts, and overexpression of genes re-quired. Salary depends upon experience (NIH scale).Send curriculum vitae to e-mail: gcortopassi@ucdavis.edu. Website: http://cortopassilab.ucdavis.edu.

UCD is an Affirmative Action/Equal Opportunity Employer.

POSITIONS OPEN

FACULTY POSITIONSin Children_s Nutrition Research

The Children_s Nutrition Research Center of theBaylor College of Medicine announces the availabilityof TENURE-TRACK POSITIONS in nutrition atthe molecular, cellular, and whole organism levels,including translational human nutrition research. Al-though positions are not limited to these areas, spe-cific interests are fetal, neonatal, and early childhoodnutrition (including fundamental mechanisms for thedevelopmental origins of adult health and disease) andobesity (including fundamental adipose tissue biology,regulation of appetite and satiety, development ofeating and physical activity behaviors, and prevention/intervention studies).The level of appointment will be consistent with

the candidate_s qualifications. Candidates should havea record of achievement through publications in peer-review journals and successful competition for extra-mural funding. In addition to a strong independentresearch program, the successful candidate will be ex-pected to have significant potential for research col-laboration with existing research programs within theChildren_s Nutrition Research Center.Interested candidates should submit their curric-

ulum vitae, a statement of research interests, andthree letters of recommendation to: Dennis M. Bier,M.D., Director, Children_s Nutrition ResearchCenter, Baylor College of Medicine, 1100 Bates,Houston, TX 77030-2600.

Baylor College of Medicine is an Equal Access/EqualOpportunity/Affirmative Action Employer.

SENIOR GENOMICS SCIENTIST

Are you interested in systems genetics?Do youwant tomake an impact ongenomics research?At RTI International, you can use your experience,

creativity, and bioinformatics skills to address cutting-edge problems in genetics and genomics.Qualifications include: motivation to establish an

independent research program; demonstrated ability tosecure funding; experience with development of data vi-sualization tools; experience with analysis of complexdata sets.To learn more and apply, visit website: http://

www.rti.org/job11323.We are proud to be an Equal Employment Opportunity/

Affirmative Action Employer, Minorities/Females/Persons withDisabilities/Veterans.

The Center for Genomics and Bioinformatics(CGB) at Indiana University, Bloomington, carriesout independent research in the fields of functionalgenomics, environmental toxicology, ecology and evo-lution. The CGB has recently acquired an Illumina se-quencer to partner with its Roche Titanium sequencer.We seek a Bioinformatics Staff Scientist (at the levelof RESEARCH ASSOCIATE) to handle the datafrom these platforms, and to develop programs to an-alyze the data.The ideal candidate will have strong programming

skills in PERL, Cþþ and possibly Java. Understand-ing of basic biological language would be an asset.Ability to design and develop algorithms would alsobe highly preferred. We require a Masters degree inComputer Science or equivalent. For more details, visitour website: http://cgb.indiana.edu/careers/.Applications received by July 31, 2009 will be as-

sured full consideration for an immediate start date.Send questions to email:job@cgb.indiana.edu. Submita curriculum vitae and a description of your backgroundand interests, and have three (3) letters of recommen-dation sent to: Bioinformatics Staff Scientist CGB-015, Center for Genomics and Bioinformatics, In-diana University, 1001 E. 3rd St., Bloomington, IN47405.

Indiana University is an Affirmative Action Equal Opportu-nity Employer.

POSITIONS OPEN

ASSISTANT PROFESSORPlant Virology

The Plant Pathology Department at the Universityof Wisconsin-Madison invites applications for a tenure-track faculty position in Plant Virology at the assistantprofessor level. Research will focus on the biology ofplant viruses and their interaction with plants. Weexpect the incumbent to interact with other programsto bridge basic and applied research. The incumbentwill mentor graduate and undergraduate students andsupport the university_s teaching and training missions.The 9-month appointment carries a 70% research /30% teaching distribution of effort. Requirements in-clude a Ph.D. in plant pathology, virology, or relateddiscipline; a strong foundation in the principles andconcepts of plant pathology and relevant researchexperience; effective oral and written communicationskills; and a positive attitude for teamwork, includingthe ability to lead and motivate. To apply, submit acurriculum vitae, a cover letter with a statement ofresearch and teaching interests, a copy of undergraduateand graduate transcripts, and three letters of referenceto: Professor Amy Charkowski, Plant PathologySearchChair, 1630LindenDr.,Madison,WI53706.Applications received by August 21, 2009 are as-

sured full consideration; review of applications will con-tinue until a suitable candidate is identified.

TheUniversity ofWisconsin is an EqualOpportunity/AffirmativeAction Employer. Unless confidentiality is requested in writing,information regarding applicants must be released upon request.Finalists cannot be guaranteed confidentiality.For job details see website: http://www.ohr.

wisc.edu/pvl/pv_060664.html

POSTDOCTORAL FELLOW (29UC3649)

The University of Cincinnati is currently acceptingapplications for a Postdoctoral Fellow. The postdoc-toral fellow will participate in ongoing research projectsusing inducible transgenic mouse models created inthe Ophthalmic Research Laboratories in the Depart-ment of Ophthalmology.Job description: to examine the molecular and cel-

lular mechanism(s) of ocular surface morphogenesisduring embryonic development and pathogenesis ofdiseases using binary inducible transgenic mouse linesthat are currently available in the Ophthalmic ResearchLaboratories in the Department of Ophthalmology.Minimum qualifications: Ph.D. in life sciences or

M.D.Ideal qualifications: Individuals with a strong back-

ground in molecular biology, molecular genetics, orprotein chemistry are preferred.To apply for position (29UC3649), please see

website: http://www.jobsatuc.com.The University of Cincinnati is an Affirmative Action/Equal

Opportunity Employer. UC is a smoke-free work environment.

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26 JUNE 2009 VOL 324 SCIENCE www.sciencecareers.org1752