scientific background nobel chemistry 2010

8/8/2019 Scientific Background Nobel Chemistry 2010

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6 OCTOBER 2010

Scientifc Background on the Nobel Prize in Chemistry 2010

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Palladium-Catalyzed Cross Couplings inOrganic Synthesis

Three researchers share this years Nobel Prize in Chemistry, ProfessorRichard F.

Heck, who has been working at University of Delaware, Newark, Delaware, USA,

ProfessorEi-ichi Negishi, Purdue University, West Lafayette, Indiana, USA, and

Professor (emeritus)Akira Suzuki, Hokkaido University, Sapporo, Japan. The Royal

Swedish Academy of Sciences is rewarding the three chemists for: palladium-catalyzed

cross couplings in organic synthesis. The discoveries by the three organic chemists have

had a great impact on academic research, the development of new drugs and materials,

and are used in many industrial chemical processes for the synthesis of pharmaceuticals

and other biologically active compounds. A background and description of their

discoveries are given below.

Introduction

This years Nobel Prize in Chemistry concerns the development of methods for palladium-

catalyzed formation of carbon-carbon bonds via so-called cross-coupling reactions. The

formation of new carbon-carbon bonds is of central importance in organic chemistry and a

prerequisite for all life on earth. Through the assembly of carbon atoms into chains, complex

molecules, e.g. molecules of life, can be created. The importance of the synthesis of carbon-

carbon bonds is reflected by the fact that Nobel Prizes in Chemistry have previously been given

to this area: The Grignard reaction (1912), the Diels-Alder reaction (1950), the Wittig reaction

(1979), and olefin metathesis to Y. Chauvin, R. H. Grubbs, and R. R. Schrock (2005).

Transition metals in synthetic organic chemistry

During the second half of the 20th century, transition metals have come to play an important

role in organic chemistry and this has led to the development of a large number of transition

metal-catalyzed reactions for creating organic molecules. Transition metals have a unique ability

to activate various organic compounds and through this activation they can catalyze the

formation of new bonds. One metal that was used early on for catalytic organic transformations

was palladium. One event that stimulated research into the use of palladium in organic

chemistry was the discovery that ethylene is oxidized to acetaldehyde by air in a palladium-

catalyzed reaction and this became the industrially important Wacker process.1 Subsequentresearch on palladium-catalyzed carbonylation led to new reactions for the formation of carbon-

carbon bonds. In general, transition metals, and in particular palladium, have been of

importance for the development of reactions for the formation of carbon-carbon bonds. In 2005

the Nobel Prize in chemistry was awarded to metal-catalyzed reactions for the formation of

carbon-carbon double bonds. This year the Nobel Prize in chemistry is awarded to the formation

of carbon-carbon single bonds through palladium-catalyzed cross-coupling reactions.

Palladium-catalyzed carbon-carbon bond formation via cross coupling

The principle of palladium-catalyzed cross couplings is that two molecules are assembled on the

metal via the formation of metal-carbon bonds. In this way the carbon atoms bound topalladium are brought very close to one another. In the next step they couple to one another and

this leads to the formation of a new carbon-carbon single bond. There are two types of cross-


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coupling reactions according to this principle that have become important in organic synthesis.

These two types of reactions are shown in equations 1 and 2.

RX + R'Pd(0)

RX + R''MPd(0)

R'R

R R''

via

via PdR''

R

PdR

R'

(1)

(2)

electrophilicpartner

electrophilicpartner

nucleophilicpartner

nucleophilicpartner

organopalladiumintermediate

organopalladiumintermediate

Both reactions are catalyzed by zerovalent palladium and both reactions employ anorganohalide RX (or analogous compound) as the electrophilic coupling partner. However, the

nucleophilic coupling partner differs in the two reactions. In the first type (eq. 1) it is an olefin

whereas in the second type (eq. 2) it is an organometallic compound RM. In this way the

palladium-catalyzed cross-coupling reactions in equations 1 and 2 complement one another as

regards the nucleophilic coupling partner. A common feature of the two types of cross couplings

is that the organic groups from the reagents are assembled on palladium. Furthermore, both

reactions begin by generating an organopalladium complex RPdX from the reaction of the

organic halide with Pd(0). The organopalladium species RPdX will subsequently react with the

nucleophilic coupling partner (see detailed mechanisms below). The reactions are very mild

since they utilize organic halides (or analogous compounds) and olefins or organometallic

compounds RM of low reactivity, where M is typically zinc, boron, or tin.

Hecks pioneering work on cross couplings involving olefins

In 1968 Heck reported in a series of papers2 that in situ-generated methyl- and phenylpalladium

halides (RPdX; R = Me, Ph; X = halide) are added to olefins at room temperature. The addition

of phenylpalladium chloride (PhPdCl) to ethylene followed by elimination of palladium gave

styrene (eq. 3).

PhPdCl + CH2=CH2 CH2 CH2

PdClPh

-hydrideelimination

Ph + HPdCl

-HCl

Pd(0)

(3)

Through this discovery Heck had designed an unprecedented reaction an arylation (or

alkylation) of an olefin. This reaction was to become one of the most important reactions for

making carbon-carbon single bonds. In these early examples the organopalladium compound,

RPdX (R = aryl or alkyl), was generated from an organomercury compound, RHgX, and a

palladium(II) salt. Since palladium(0) is formed at the end of the reaction shown in equation 3,

the overall reaction is not catalytic if it is run without any additives. In one of the papers

published in 1968 Heck demonstrated that the reaction can be made catalytic with respect to

palladium by the use of CuCl2 as a reoxidant for Pd(0) that is formed at the end of the reaction.2d


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Heck gave a correct mechanism for the arylation of olefins,2 and in more detailed studies in 1969

he also provided an explanation for the stereochemical course of the reaction.3

In 1972, Heck made an important modification of his reaction that increased its synthetic

utility.4 In this new version, which became the standard protocol for carrying out the Heck

reaction, the organopalladium complex RPdX is generated from an organohalide, RX, and Pd(0)

in a so-called oxidative addition. Such oxidative additions to Pd(0) had been previously reported

by Fitton,5 who in 1968 found that aryl halides react with Pd(0) to give arylpalladium halides.

Heck was aware of Fittons work and used it for generating the organopalladium complex for the

coupling reaction. Thus, with this new modification an arylation of an olefin was achieved from

the reaction of an aryl halide and an olefin in the presence of a palladium catalyst. The

mechanism of the Heck reaction is shown in Scheme 1.

Scheme 1. Mechanism of the Heck reaction.

The reaction begins when the active Pd(0) catalyst reacts with the organohalide RX in a so-

called oxidative addition. In this reaction the oxidation state of palladium formally changes from

Pd(0) to Pd(II) with the formation of an organopalladium compound RPdX. In this process a

new palladium-carbon bond is formed. In the next step the olefin co-ordinates to palladium, and

the olefin and the R group are now assembled on the metal and can react with one another. In

the next step the R group on palladium migrates to one of the carbons of the co-ordinated olefin

and palladium will shift to the other carbon of the olefin. This process is called a migratory

insertion and generates the carbon-carbon bond. Finally, the release of the organic group occurs

via a -hydride elimination which forms the new olefin in which the R group from the

organohalide RX has replaced a hydrogen atom on the substrate olefin. In this step a short-lived

HPdX species is formed, which loses HX to give Pd(0). The Pd(0) species formed is now ready

to enter another catalytic cycle.


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Other researchers have also contributed to the development of this reaction. I. Moritani and Y.

Fujiwara6 observed in 1967 that benzene reacts with olefins to give styrenes. After Hecks papers

in 1968 and 1969 they realized7 that the reaction occurs via arylpalladium species. In 1971, T.

Mizoroki, stimulated by the earlier studies by Heck and Fujiwara, reported that iodobenzene

arylates alkenes in the presence of a palladium catalyst to give styrenes. 8

Negishis development of a mild cross coupling

Transition metal-catalyzed reactions of Grignard reagents (as arylmagnesium bromides) and

organohalides in the presence of catalytic amounts of salts of cobalt, nickel and iron were

reported by Kharasch in 1941 to give high yields of biaryls, this was however, via homocoupling

of the Grignard reagent.9 Carbon-carbon bond formation via copper-catalyzed coupling between

methylmagnesium bromide and methyl iodide was also reported by Gilman in 1952. 10 These

cross couplings with the aid of copper were further studied in the 60s. Also, Kochis work on

iron-catalyzed cross coupling from 1971 should be mentioned.11 In 1972 the teams of Corriu

(using nickel acetylacetonate)12 and Kumada (using nickel phosphine complexes)13

independently reported nickel-catalyzed cross couplings between Grignard reagents and aryl or

vinyl halides. This reaction was extended to palladium by Murahashi in 1975.14 The highly

reactive organometallic species, RM, such as Grignard reagents, RMgX, or organolithium

compounds, RLi, which had been employed in these early cross-coupling reactions do not

tolerate certain functional groups and are associated with low chemoselectivity. Therefore, the

use of these reagents in cross-coupling reactions was not optimal for synthetic applications.

In 1976, Negishi initiated a series of studies to explore more chemoselective organometallic

species in the palladium-catalyzed couplings with organohalides.15 In the first studies Negishi

employed organozirconium or organoaluminium compounds as coupling partners.15 The

positive results obtained from these studies stimulated him to try even less reactive

organometallic species. The breakthrough came in 1977 when Negishi introduced organozinc

compounds as the nucleophilic coupling partners in palladium-catalyzed cross coupling.16 The

organozinc compounds gave superior yields compared to other organometallic compounds, and

furthermore, they were very mild and highly selective. The use of organozinc compounds in the

palladium-catalyzed cross-coupling reaction allowed for the presence of a wide range of

functional groups; this was in contrast to previous methods employing a Grignard reagent or an

organolithium compound as the nucleophilic coupling partner. The new coupling reactionbecame a very important method for making carbon-carbon single bonds and it is called the

Negishi reaction (eq. 4).

Negishi also noted in 1978 that an alkynylboron compound coupled with an organic halide in

the presence of a palladium catalyst. He did not pursue the use of organoboron compounds as

nucleophilic coupling partners and there is only a single example reported in a book chapter.17The use of organoboron compounds in cross-coupling reactions with organohalides is discussed

below (Suzuki reaction).


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Other researchers have also made important contributions to the use of organozinc reagents in

palladium-catalyzed cross coupling. J. F. Fauvarque and A. Jutand reported in 1977 that zinc

enolates in the form of Reformatzky reagents couple with aryl halides in the presence of a Pd(0)

catalyst to give a new carbon-carbon bond.18 P. Knochel has widened the scope of oligo-

functional organozinc derivatives and thus enhanced the synthetic utility of the Negishi

reaction.19

Suzukis discovery of a practical process

In 1979 Suzuki and co-workers reported in two papers that organoboron compounds in the

presence of a base can be used as coupling partners in palladium-catalyzed cross coupling with

vinyl and aryl halides (eq. 5).20 Thus, base activation of organoboron reagents as boronate

intermediates facilitated the transfer of the organic group from boron to palladium

(transmetallation). The reaction has later been extended to also include couplings with alkyl

groups.

A further significant development came from the observation that arylboronic acids are able to

participate as coupling partners in the palladium-catalyzed cross-coupling reaction. In the latter

case the reaction was even more efficient and weaker bases could be employed. The stability and

weak nucleophilic nature of organoboron compounds has made this reaction very practical. It

tolerates a wide range of functional groups and it is highly chemoselective. Furthermore, boron

compounds are generally non-toxic and the reaction can be run under very mild conditions. This

has made the reaction popular in the pharmaceutical industry. The reaction is called the Suzuki

reaction.

Other researchers have contributed to the development of using organoboron compounds as

coupling partners and in 1975, H. A. Dieck and Heck employed vinyl boronic acids as coupling

partners with olefins in stoichiometric Heck reactions.21 As mentioned above, Negishi showed

one example of coupling with an alkynylboron compound. Also, N. Miyaura (who was Suzukis

associate professor at the time) later made several important improvements on boron

couplings.22 The Suzuki reaction has been extended to aryl chlorides by G. C. Fu by the use of

sterically hindered phosphine ligands.23

The mechanism of the Negishi and Suzuki cross-coupling reactions

In the Negishi and Suzuki cross-coupling reactions an organozinc or organoboron compound,

respectively, couples with an organohalide (or an analogous compound such as an organotriflate

or a diazo compound) in the presence of a catalytic amount of a palladium(0) complex. The

reaction leads to the formation of a new carbon-carbon single bond. The mechanism of these

palladium-catalyzed cross-coupling reactions is given in Scheme 2.


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Scheme 2. Mechanism of the Negishi and Suzuki palladium-catalyzed cross-coupling reactions.

The first step in the Negishi and Suzuki cross-coupling reactions is identical to that of the Heck

reaction. This step is an oxidative addition of RX to Pd(0) to give an organopalladium

compound. In the second step the organic group, R on zinc or boron, is transferred to palladium

in a process called transmetallation. In this way the two organic groups are assembled on the

same palladium atom via palladium-carbon bonds. In the final step the R and R groups couple

with one another to give a new carbon-carbon single bond and R-R is released from palladium.

In this process Pd(II) is reduced to Pd(0) and therefore the final step is called a reductive

elimination. Such a reductive elimination was demonstrated by A. Yamamoto in 1970 with the

use of a diethylnickel complex.24 The nickel complex employed is electronically analogous to the

diaorganopalladium complex formed in the catalytic cycle. Yamamoto found that by heating or

adding an electron-withdrawing ligand to these diethylnickel complexes they underwent a

reductive elimination to give butane and a nickel(0) complex.

Contributions to the understanding of the mechanism of metal-catalyzed cross-coupling

reactions have also been made by M. Kumada and K. Tamao.13 These researchers reported on a

related nickel-catalyzed cross coupling in 1972 and they proposed a mechanism via oxidative

addition, transmetallation, and reductive elimination (cf. Scheme 2). S.-I. Murahashi 14 reported

a palladium-catalyzed cross coupling between Grignard reagents and organohalides in 1975.

Important contributions for the synthetic development of palladium-catalyzed cross coupling

have also been made by the groups of T. Migita25 and J. K. Stille26, who in 1977 and 1978,

respectively, developed palladium-catalyzed cross couplings using an organotin compound as

the nucleophilic coupling partner. Organotin compounds are stable organometallic compoundswith low reactivity and give mild reaction conditions. The reaction developed became known as

the Stille reaction and is used as an alternative to the Negishi and Suzuki reactions for


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substrates with sensitive functional groups. However, the toxicity of organotin compounds has

limited their industrial use.

Application of palladium-catalyzed cross couplingsThe palladium-catalyzed carbon-carbon bond forming reactions developed by Heck, Negishi and

Suzuki have had a large impact on synthetic organic chemistry and have found many

applications in target oriented synthesis. Their widespread use in organic synthetic applications

is due to the mild conditions associated with the reactions together with their tolerance of a wide

range of functional groups. These three cross-coupling reactions have been applied to the

synthesis of a large number of natural products and biologically active compounds of complex

molecular structures. They have also found applications in the fine chemical and pharmaceutical

industries. Some examples of the use of the Heck, Negishi, and Suzuki reactions in natural

product synthesis and industrial applications are given below.

The Heck reaction has been used in more than 100 different syntheses of natural products and

biologically active compounds. Two examples are given in Scheme 3. The first example is for the

synthesis of Taxol, where the Heck reaction was employed for creating the eight-membered

ring.27 The ring closure to complete the rigid tricyclic system is not trivial. In the other example

an intramolecular Heck-type coupling provides the morphine skeleton and the product is

transformed to morphine in a few steps.28

N

MeO

OBn

I

DBS

H

NDBS N

O

Me

OH

OMe OH

Morphine

base, toluene

Heck reaction

Pd(OCOCF3)2PPh3)2OBn

Scheme 3. Examples of the use of the Heck reaction in natural product synthesis (refs. 27 and28)


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The Heck reaction has also been used as an important carbon-carbon bond-forming step in the

synthesis of other complex organic molecules such as steroids,29 strychnine,30 and the

diterpenoid scopadulcic acid B31 with cytotoxic and antitumor activity.

The Negishi and Suzuki reactions have also been frequently employed in natural product

synthesis. Pumiliotoxin A is a toxic alkaloid found in the skin of frogs from the Dendrobatidae

family that the frog uses for its defence. The total synthesis of pumiliotoxin A was performed via

the use of a Negishi coupling in one of the key steps (Scheme 4). 32It is interesting to note that an

alkylzinc compound with -hydrogens is used in this reaction.

Scheme 4. The use of the Negishi coupling in the synthesis of Pumiliotoxin A (ref. 32).

An efficient synthesis of the potent natural antitumor agent (+)-dynemicin A involved a Suzuki

coupling in one of the key carbon-carbon bond forming steps (Scheme 5).33


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Scheme 5. An efficient Suzuki coupling in the synthesis of (+)-dynemicin A (ref. 33).

There are a number of natural product syntheses reported in the literature that rely on the

Negishi and Suzuki couplings for carbon-carbon bond formation. Two more examples are given

in Figure 1. The Negishi coupling was employed in the synthesis of the natural marine antiviral

product hennoxazole A34 and the Suzuki reaction was used for preparing the antiviral

bromoindole alkaloid dragmacidin F.35 At the cross coupling stage there were several sensitive

functional groups present, and therefore mild reagents such as an organoboron or organozinc

reagent are required.

N

N

O

NH

Br

dragamacidin F

NO

H

HO

HN

HN

H2N

H

+

Suzuki couplings

Figure 1. Synthesis of hennoxazole A (ref 34) and dragmacidin F (ref 35) via palladium-catalyzed cross coupling.

The palladium-catalyzed cross-coupling reactions are suitable for carrying out on a large scale

and the Heck reaction has been used for a number of large scale industrial applications. Several

of these processes are run on a multiton scale per year. The sulfonyl urea herbicide Prosulforon

is produced on a large scale with a process developed by Ciba-Geigy (Scheme 6). The key step is

a Heck reaction, where a diazonium salt generates an arylpalldium intermediate, which couples

with the olefin.


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Further reading

Metal-Catalyzed Cross-Coupling Reactions, Eds A. de Meijere and F. Diederich, Wiley-VCH,

Weinheim, 2004, vols 1 and 2.

Accounts of Chemical Research, November Issue 2008, Special Issue on Cross Coupling.

scientific background nobel chemistry 2010

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