scientiﬁ c programme - aim group...causes and consequences of microrna dysregulation in cancer c...

Scientifi c Programme

52nd Annual Meeting of the Italian Cancer Society

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M ond ay , O ctob er 4

14.00-19.00 REGISTRATION AND POSTER HANGING

15.00-16.15 OPENING CEREM ONY Greetings from the Authorities

Greetings from AACR M . F oti (American Association for Cancer Research, Philadelpia, USA)

16.15-17.00 OPENING LECTURE Functions of w ild type and mutant p53 K . V ou sd en (G lasg ow , UK ) - Sponsored b y F ondaz ione F ederico Calab resi

1 7 .0 0 - 1 9 .0 0 C A N C E R ST E M C E L L S C h airs: S. Pece (M ilan, Italy ), P.G . N atali (Rome, Italy )

Cancer stem cells from solid tumors: tow ards clinical application R . D e M aria (Rome, Italy )

O1 CANCER INITIATING CELLS IN K-RASG12V INDUCED LUNG ADENOCARCINOM A S. M ainardi (F u ndació n Centro N acional de Inv estig aciones O ncoló g icas - M adrid, Spain), M . B arb acid

Endocytosis, stem cells and cancer P.P. D i F iore (M ilan, Italy )

O2 EPITHELIAL-M ESENCHYM AL TRANSITION CONFERS STEM -LIKE PROPERTIES TO LUNG TUM OR CELLS

G . B ertolini (F ondaz ione IRCCS N ational Cancer Institu te, M ilan, Italy ), L . Roz , M . B oeri, G . Soz z i

Stem cells and breast cancer: treatment resistance, markers and novel therapeutic targets R .B . C lark e (M anchester, UK ) - Sponsored b y E ACR

1 9 .0 0 W elcome C ock tail at th e “ C h iostro” and gard en of th e A ngelicu m C ongress C entre

b ridging the gap b etw een cancer researchand effectiv e therap ies


Lost in translation:Lost in translation:Rom e, 4 - 7 October 2010Rom e, 4 - 7 October 2010

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Angelicum Congress CentreAngelicum Congress Centre


T u esd ay , O ctob er 5

8.00 - 18.30 REGISTRATION

0 8 .3 0 - 1 2 .3 0 E PI G E N E T I C A L T E R A T I O N S I N C A N C E R C h airs: S. T ommasi (B ari, Italy ), G . V ecch io (N aples, Italy )

p73/p63 in cancer progression G . M elino (Rome, Italy )

O3 ENDOGENOUS C-JUN ACTS AS A NEGATIVE M ODULATOR IN M OUSE HEPATOCYTE PROLIFERATION INDUCED BY LIGANDS OF NUCLEAR RECEPTORS

A. Colu mb ano (Univ ersity of Cag liari, Italy ) , V . L eoni, G .M . L edda-Colu mb ano, M . Pib iri, C. Salib a, A. Perra, M .A. K ow alik , O .M .V . G rob e, M . Rav o, A. W eisz , E . G hiso, S. G iordano

A systems biology approach to decipher Acute M yeloid Leukemia H .G . Stu nnenb erg (N ijmeg en, T he N etherlands)

O4 ONCOSUPPRESSOR M ETHYLATION: A POSSIBLE KEY ROLE IN COLON M ETASTATIC PROGRESSION

R. Pinto (N ational Cancer Centre “ G iov anni Paolo II” , B ari, Italy), D . Petriella, R. L acalamita, G . Iannelli, N . Silv estris, G . Colu cci, A. Paradiso, S. T ommasi

The epigenetic regulator N F-Y as a track of cell proliferation in vivo G . Piaggio (Rome, Italy )

10.30-11.00 Coffee break

Cancerous microRN As and regulatory RN A binding proteins R . A gami (Amsterdam, T he N etherlands)

O5 M IR-1 DOW NREGULATION PLAYS A CRITICAL ROLE IN THYROID CELL PROLIFERATION V . L eone (IE O S-CN R, “ F ederico II” Univ ersity, N aples, Italy), D . D ’Angelo, P.L . Pallante, A. F erraro, E . B orb one, A. F u sco


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Scientifi c ProgrammeO6 HIPK2-M EDIATED PHOSPHORYLATION OF H2B AT M IDBODY IS REQUIRED FOR CYTOKINESIS

C. Rinaldo (Regina E lena N ational Cancer Institu te, Rome, Italy), A. M oncada, F . Siepi, A. G radi, L . Ciu ffi ni, D . D ’E liseo, G . Pierantoni, F . E sposito, F . T rapasso, A. G iorg i, E . Cu ndari, A. F u sco, E . Schininà , S. Soddu

Causes and consequences of microRN A dysregulation in cancer C .M . C roce (Colu mb u s, USA)

12.30-12.45 Greetings from Italian M inistry of W elfare Sen. M au riz io Sacconi

12.45-13.00 The social burden of cancer and the strategic importance of research F . C ognetti (Rome, Italy )

13.00-14.00 Lunch and poster view ing

14.00-17.00 PARALLEL PO STER DISCUSSIO N S

1 4 .0 0 - 1 5 .3 0 PO ST E R D ISC U SSI O N ( A U L A M A J O R ) :M OL E C U L A R M A R K E R S OF D IA G N OS IS , P R OG N OS IS , A N D R E S P ON S E T O T H E R A P Y

C h airs: G . B ev ilacq u a (Pisa, Italy ), G . Soz z i (M ilan, Italy )

P 3 0 6 M ICRORNA EXPRESSION PROFILES OF TUM ORS, NORM AL LUNG TISSUES AND PLASM A SAM PLES FROM SPIRAL-COM PUTED TOM OGRAPHY (CT) TRIAL FOR EARLY LUNG CANCER DETECTION M . B oeri (F ondaz ione IRCCS N ational Cancer Institu te, M ilan, Italy ), C. V erri, L . Roz , D . Conte, P.G . M odena, F . F acchinetti, C.M . Croce, U. Pastorino, G . Soz z i

P 29 1 M ICRORNAS INVOLVEM ENT IN FLUDARABINE REFRACTORY CHRONIC LYM PHOCYTIC LEUKEM IA M . F erracin (Univ ersity of F errara, Italy ), B . Z ag atti, L . Riz z otto, F . Cav az z ini, M . Ciccone, E . Saccenti, L . L u pini, M . N eg rini, A. Cu neo

P 26 9 PATHW AY PROFILING OF LASER CAPTURE M ICRODISSECTED COLORECTAL CANCER REVEALS THE PRESENCE OF EARLY M ARKERS OF AGGRESSIVENESS A. Silv estri (CRO -IRCCS, N ational Cancer Institu te, Av iano, Italy ), C. B ellu co, M . Pierob on, E . M ammano, V . Calv ert, J . D eng , F . D e M archi, A. Colomb atti, D . N itti, L . L iotta, E . Petricoin




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Scientifi c ProgrammeP 28 2 TRANSCRIPTIONAL M ODULES PREDICTING RESPONSE TO EGFR-TARGETED THERAPY OF

KRAS- AND BRAF-W ILD TYPE COLORECTAL CANCERS E . M edico (Institu te for Cancer Research and T reatment, Univ ersity of T u rin, Candiolo, Italy ),

C. Petti, G . Picco, A. B ertotti, L . T ru solino, C. Isella

P 29 8 A M OUSE TO HUM AN AUTOANTIBODY SIGNATURE IN PANCREATIC DUCTAL ADENOCARCINOM A M . Capello (Center for E x perimental Research and M edical Stu dies (CeRM S), Univ ersity of

T u rin, Italy), P. Cappello, F .C. L inty, A. Scarpa, P. Pederz oli, P. N isticò , M . M ilella, F . N ov elli

P 5 9 HM ENA/HM ENA11A COOPERATE W ITH EGFR FAM ILY SIGNALLING PATHW AYS IN BREAST CANCER P. T rono (Reg ina E lena N ational Cancer Institu te, Rome, Italy ), F . D i M odu g no, M . M ottolese, I .

T errenato, L . D eM onte, A. D i B enedetto, F . B elleu di, A. Santoni, P. N isticò

P 29 0 BLOCKING ERBB-3/P85 INTERACTION BY A PHOSPHOTYROSYL PEPTIDE INDUCES APOPTOSIS IN BREAST CANCER. A NEW STRATEGY TO ESCAPE HERCEPTIN RESISTANCE

V . F olg iero (Reg ina E lena N ational Cancer Institu te, Rome, Italy ), S.E . D i Carlo, G . B on, E . Spu g nini, A. D i B enedetto, M . M ilella, A. F ab i, M . M ottolese, G . B ossi, R. F alcioni

P 27 3 ROLE OF DELTA16HER2 SPLICE VARIANT IN HER2-DRIVEN TUM OR GROW TH S. Pu pa (F ondaz ione IRCCS, N ational Cancer Institu te, M ilan, Italy ), A. Rossini, F . G ab rielli,

C. M archini, V . Cirav olo, P.A. Aiello, M . M ontani, L . Pietrella, M . Iez z i, P. M u siani, E . T ag liab u e, S. M énard, A. Amici

P 26 8 STATHM IN EXPRESSION AND P53 STATUS: A NEW RATIONALE FOR THE M ANAGEM ENT OF OVARIAN CANCER

M . Soneg o (CRO -IRCCS, N ational Cancer Institu te, Av iano, Italy ), M . Schiappacassi, M . B ag noli, A. D all’acq u a, S. L ov isa, S. Canev ari, G . B aldassarre

P 3 0 8 M ASPIN EXPRESSION IS A FAVORABLE PROGNOSTIC FACTOR IN NON-SM ALL CELL LUNG CANCER R. B erardi (Univ ersità Politecnica delle M arche, Ancona, Italy), A. Santinelli, A. O nofri,

M . Scartoz z i, E . Pisa, A. B ru nelli, D . Stramaz z otti, A. Sab b atini, S. G asparini, A. F ianchini, S. Cascinu


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Scientifi c Programme1 4 .0 0 - 1 5 .3 0 PO ST E R D ISC U SSI O N ( A U L A M I N O R ) :C A N C E R G E N E T IC , D N A D A M A G E , S IG N A L T R A N S D U C T ION

C h airs: A . Sacch i (Rome, Italy ), M .L . Poeta (Rome, Italy )

P 214 EPIGENETIC M ECHANISM S UNDERLYING THE TRANSCRIPTIONAL REGULATION OF THE M ICRORNA LET-7C IN ACUTE PROM YELOCYTIC LEUKEM IA

S. Careccia, A. Pelosi (Regina E lena N ational Cancer Institu te, Rome, Italy), V . Az z imato, N .G . Su k u b o, A. G u rtner, J . M artens, M . L ev rero, H .G . Stu nnenb erg , G . Piag g io, M .G . Riz z o

P 17 8 TRANSCRIPTIONAL REPROGRAM M ING BY E1A-ONCOGENE F . N icassio (I F O M F ou ndation, M ilan, Italy ), M . M arz i, E . Pu g g ioni, V . D all’O lio,

L . B ernard, M . Crescenz i, F . B ianchi, P.P. D i F iore

P 218 DECIPHERING THE TRANSCRIPTIONAL COM PLEX CRITICAL FOR EPIGENETIC REGULATION OF ENDOTHELIN-1 GENE EXPRESSION IN OVARIAN CANCER

L . Rosanò (Reg ina E lena N ational Cancer Institu te, Rome, Italy ), R. Cianfrocca, V . D i Castro, F . Spinella, P.G . N atali, A. B ag nato

P 3 22 CHE-1 PROM OTES TUM OR CELL SURVIVAL BY SUSTAINING M UTANT P53 TRANSCRIPTION AND INHIBITING DNA DAM AGE RESPONSE ACTIVATION

A. D esantis, T . B ru no, G . B ossi, S. D i Ag ostino, C. Sorino, F . D e N icola, S. Iez z i, A. F ranchitto,B . B enassi, S. G alanti, F . L a Rosa, A. F loridi, C. Passananti, G . B landino, M . F anciu lli (Reg ina E lena N ational Cancer Institu te, Rome, Italy )

P 3 24 INDUCTION OF OCT-6/TST-1 POU DOM AIN TRANSCRIPTION FACTOR BY DOXORUBICIN: ROLE IN THE CONTROL OF REACTIVE OXYGEN SPECIES

M . Cippitelli (“Sapienz a” Univ ersity and Reg ina E lena N ational Cancer Institu te, Rome, Italy ), D . D i B ona, C. F ionda, G . M alg arini, A. Santoni




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Scientifi c ProgrammeP 6 3 THE EXPRESSION AND SUB-CELLULAR LOCALIZATION OF BCRP ARE AFFECTED BY EGFR

PATHW AY IN NSCLC L . Porcelli (N ational Cancer Institu te “ G iov anni Paolo II” , B ari, Italy ), G . Jansen, E . G iov annetti,

G .L . Scheffer, G .J .P. Peters, A. Paradiso, A. Az z ariti

P 5 7 TARGETING IGF SIGNALING IN HERCEPTIN-RESISTANT BREAST CANCER S. N apoletano (Royal Colleg e of Su rg eons, D u b lin, Ireland), K . Ilm, J.H . H armey

P 19 4 ABLACTIVITY IS REQUIRED FOR M ET-TRIGGERED CELL SURVIVAL AND TUM ORIGENESIS A. F u rlan, A. H u ssain, V . Stagni, S. Richelme, F . Conti, A. M ou men, A. Prodosmo, A. D estro,

I. D el B arco B arrantes, J.S.C. Arthu r, A. N eb reda, M . Roncalli, D . B arilà (IRCCS F ondaz ione Santa L u cia, Univ ersity of T or V erg ata, Rome, Italy ), F . M aina

P 7 1 IDENTIFICATION OF NEW KINASES INVOLVED IN THYROID CARCINOGENESIS THROUGH AN RNA INTERFERENCE SCREEN

M . Castellone (IE O S-CN R, “ F ederico II” Univ ersity, N aples, Italy ), M .C. Cantisani, M . M u thu , R. B ellelli, O . K allioniemi, M . Santoro

P 6 0 ERK5 IS OVEREXPRESSED IN EXPERIM ENTAL LIVER INJURY AND IN HEPATOCELLULAR CARCINOM A (HCC) AND IS M ODULATED BY SOLUBLE FACTORS IN HCC CELLS

E . Rov ida, N . N av ari, S. Cannito, S. G iu ntoli, G . D i M aira (Univ ersity of F lorence, Italy ), P. D ello Sb arb a, M . Parola, F . M arra

1 5 .3 0 - 1 7 .0 0 PO ST E R D ISC U SSI O N ( A U L A M A J O R ) :IN N OV A T IV E T H E R A P IE S A N D M E C H A N IS M S OF D R U G R E S IS T A N C E

C h airs: K . Scotland i (B olog na, Italy ), G . Z u p i (Rome, Italy )

P 27 FREG PEPTIDE INHIBITS M ELANOM A GROW TH IN VITRO AND IN VIVO A. F acchiano (Istitu to D ermopatico dell’Immacolata, Rome, Italy ), M .S. Ag u z z i, D . F araone,

G . T oietta, D . Rib atti, A. Paraz z oli, P. Colomb o, M .C. Capog rossi


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Scientifi c ProgrammeP 0 9 CPTH6 INHIBITS HISTONE ACETYLTRANSFERASE ACTIVITY IN HUM AN LEUKAEM IA CELL LINES Y . Ragaz zoni, C. G ab ellini (Regina E lena N ational Cancer Institu te, Rome, Italy ), A. Pelosi, M . D esideri,

P. F iletici, D . Secci, M .G . Riz z o, D . D el B u falo, D . T risciu og lio

P 4 9 CHARACTERIZATION OF A NEW M YXOID LIPOSARCOM A RESISTANT CELL LINE: INVOLVEM ENT OF TRANSCRIPTION REGULATION

S. D i G iandomenico (M ario N eg ri Institu te for Pharmacolog ical Research, M ilan, Italy ), I . F u so N erini, S. Ub oldi, S. B ernasconi, M . Romano, F . Sala, G . D amia, M . G anz inelli, E . E rb a, M . D ’Incalci

P 4 8 PRECLINICAL RESULTS OF HUM AN M ONOCLONAL ANTIBODY ANTI-IGF1R AVE1642 (SANOFI-AVENTIS) IN EW ING’S SARCOM A AND POSSIBLE M ECHANISM OF RESISTANCE

C. G arofalo (O rthopaedic Riz z oli Institu te, B olog na, Italy ), M .C. M anara, M .T . M arino, P. Picci, K . Scotlandi

P 29 ACTIVITY OF ZOLEDRONIC ACID ON THE INTERACTION BETW EEN M ESENCHYM AL STEM CELLS AND BREAST CANCER CELLS

N . N ormanno (N ational Cancer Institu te “ G . Pascale” , N aples, Italy ), M . G allo, L . L amu ra, A. D e L u ca

P 4 2 THE P38 KINASE PATHW AY IS INVOLVED IN THE RESISTANCE OF PROSTATE CANCER CELLS TO ZOLEDRONIC ACID

B . Pu cci (O ncolog y Research Center, M ercog liano, Italy ), M .R. M ilone, M . Rocco, G . Piro, F . B ru z z ese, A. B u dillon

P 3 8 M ETABOLIC ALTERATIONS AND PROTEOM IC PROFILE OF HUM AN CANCER CELLS RESISTANT TO HER INHIBITORS

R. Rosa (“ F ederico II” Univ ersity, N aples, Italy ), M . V itale, F . M onteleone, L . Cardone, T . G elardi, R. B ianco, V . D amiano, M . Su ccoio, C. D ’amb rosio, A. Scaloni, N . Z amb rano, G . T ortora

P 7 9 COM BINATIONS OF RETINOIDS AND LAPATINIB IN THE TREATM ENT OF BREAST CARCINOM AS W ITH CO-AM PLIFICATION OF THE ERBB2 AND RARA GENES

G . Paroni (M ario N eg ri Institu te for Pharmacolog ical Research, M ilan, Italy ), V . G u arnaccia, A. Z anetti, C. B assano, G . G ardini, E . G arattini




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Scientifi c ProgrammeP 16 SYNERGISTIC ANTITUM OR EFFECTS OF ‘VERTICAL’ COM BINATION STRATEGIES INHIBITING

M ULTIPLE STEPS ALONG THE RAF/M EK/ERK CASCADE M . M ilella (Reg ina E lena N ational Cancer Institu te, Rome, Italy ), M .R. Ricciardi, L . Ciu ffreda,

P. B erg amo, S. Iacov elli, C. D i Sanz a, U. Cesta Incani, F . Cog netti, D . D el B u falo, A. T afu ri

P 14 COM BINATIONS OF CHEM OTHERAPY AND BEVACIZUM AB IN A XENOGRAFT M ODEL OF HUM AN OVARIAN CARCINOM A

P. O liv a (M ario N eg ri Institu te for Pharmacolog ical Research, M ilan, Italy), A. D ecio, V . Castig lioni, D . B elotti, M .R. B ani, R. G iav az z i

1 5 .3 0 - 1 7 .0 0 PO ST E R D ISC U SSI O N ( A U L A M I N O R ) :T U M OR IM M U N OL OG Y A N D M IC R OE N V IR ON M E N T

C h airs: A . A nich ini (M ilan, Italy ), R . F alcioni (Rome, Italy )

P 16 3 ECO-GUIDED INTRATUM ORAL INJECTION OF CCL16 AND CPG COUPLED W ITH SYSTEM IC IL-10 INHIBITION CURES ORTHOTOPICALLY IM PLANTED TRAM P TUM ORS

G . M au ri (F ondaz ione IRCCS N ational Cancer Institu te, M ilan, Italy ), C. T ripodo, L . B ab ini, M . Parenz a, C. Chiodoni, M .P. Colomb o

P 16 7 A NOVEL BIOLOGICAL SYSTEM TO STUDY THE IM M UNE THERAPEUTIC ROLE OF LEPTIN IN CANCER M . G algani (E ndocrinolog y and E x perimental O ncolog y Institu te, CN R, N aples, Italy), G . M atarese

P 16 0 HER2/NEU OVEREXPRESSING BREAST CANCER PATIENTS RETAIN AN IM M UNOLOGICAL PROFICIENCY COM PROM ISED IN HER2/NEU-NEGATIVE CASES

E . M u raro (IRCCS N ational Cancer Institu te, Av iano, Italy), D . M artorelli, E . T u rchet, G . M iolo, S. Scalone, E . Comaro, R. T alamini, A. V eronesi, D . Criv ellari, R. D olcetti

P 10 2 CHEM OKINE NITRATION PREVENTS INTRATUM ORAL INFILTRATION OF ANTIGEN-SPECIFIC T CELLS B . M olon (Istitu to O ncolog ico V eneto IRCCS, Padu a, Italy ), S. Ug el, F . D el Poz z o, C. Soldani,

D . Av ella, A. D e Palma, A. M oneg al, B . Sav ino, A. G asco, A. V iola, V . B ronte

P 9 1 NOTCH SIGNALING PROM OTES OXIDATIVE STRESS DEFENSE: IM PLICATION IN NOTCH CANCER BIOLOGY

S. M anca, S. Cialfi , L . B arb ieri, G . B iolcati, D . Uccelletti, C. Palleschi, A. M ag relli, M . Salv atore, D . T aru scio, I. Screpanti, C. T alora (“Sapienz a” Univ ersity, Rome, Italy )


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Scientifi c ProgrammeP 24 1 M ET-ONCOGENE TRANSFORM S HUM AN PRIM ARY BONE-DERIVED CELLS BY TARGETING OSTEO

PROGENITORS N . D ani, M . O liv ero, S. Patanè, M . V anD u ist, K . M areschi, F . F ag ioli, M .F . D i Renz o (Institu te for

Cancer Research and T reatment, Univ ersity of T u rin, Candiolo, Italy )

P 128 M IRNAS IM PAIR M ET-M EDIATED INVASIVE GROW TH C. M ig liore (Institu te for Cancer Research and T reatment, Univ ersity of T u rin Candiolo, Italy ),

A. Petrelli, E . G hiso, S. Corso, L . Capparu ccia, A. E ramo, V . L eoni, L . Atz ori, L . Z orcolo, G . Casu la, A. Colu mb ano, S. G iordano

P 10 0 HIF-1 UPREGULATION BY IL-1 CONTRIBUTES TO THE M IGRATORY POTENTIAL OF BREAST CANCER CELLS

I . F ilippi, D . M ig lietta, M . M oschetta, R. G iav az z i, F . Carraro, A. N aldini (Univ ersity of Siena, Italy )

P 121 VITAM IN D3 REGULATES PDLIM 2 EXPRESSION IN M CF7 BREAST CANCER CELLS E . V anoirb eek (K atholiek e Univ ersiteit, L eu v en, B elg iu m), G . E elen, I . B u ellens, M . V an Camp,

L . V erlinden, S. M arcelis, K . M archal, R. B ou illon, A. V erstu y f

P 226 THE EFFECTS OF CARBON NANOTUBES ON ANGIOGENESIS AND M ETABOLIC FUNCTIONS E . Cesana (IRCCS M u ltiM edica, Sesto San G iov anni, M ilan, Italy), R. Cammarota, E . Principi, I.

Sogno, A. Parodi, D . N oonan, A. Alb ini


1 7 .2 0 - 1 8 .5 0 C A N C E R M O D E L I N G C h airs: S. G iord ano (T u rin, Italy ), R . G iav az z i (M ilan, Italy )

Pancreatic cancer models and medicine N . C ook (Camb ridg e, UK )

O7 GENERATING A PANCREATIC CANCER M OUSE M ODEL: FROM CANCER STEM CELLS TO IN VIVO IM AGING STRATEGIES

R. Ritelli (ARC-N E T Research Centre, Univ ersity of V erona, Policlinico G .B . Rossi, V erona, Italy ), M . D andrea, L . Calderan, F . B oschi, P. M arz ola, A. Scarpa




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Scientifi c ProgrammeO8 CELL DELIVERY OF PEPTIDES M IM ICKING THE DOCKING SITE OF M ET INHIBITS ANGIOGENESIS AND VASCULAR TUM OR GROW TH

R. Cammarota (IRCCS M u ltiM edica, Sesto San G iov anni, M ilan, Italy), A.R. Cantelmo, D .M . N oonan, C. F ocaccetti, M . Prat, A. Alb ini

M olecular basis of vascular stabilization in tumors E . D ejana (M ilan, Italy )

18.50-19.50 M eeting of SIC Young Investigators


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W ed nesd ay , O ctob er 6

0 8 .4 5 - 1 0 .3 0 M O L E C U L A R M E C H A N ISM S O F SE N E SC E N C E A N D C E L L D E A T H C h airs: R . D olcetti (Av iano, Italy ), A . Santoni (Rome, Italy )

The desirable death... of the cancer cell G . K roemer (V illeju if, F rance)

O9 CHARACTERIZATION OF A NEW CANCER-ASSOCIATED M UTANT OF P53 W ITH A M ISSENSE M UTATION (K351N) IN THE TETRAM ERIZATION DOM AIN

L . T u osto (Istitu to Pasteu r - F ondaz ione Cenci B olog netti, “ Sapienz a” Univ ersity, Rome, Italy ) M . M u scolini, E . M ontagni, S. Caristi, M . Coraz z ari, M . Piacentini, G . B landino, A. Costanz o, K . Sak ag u chi

O10 DELTA-NP63-ALPHA IS AN ONCOGENE THAT INHIBITS SENESCENCE AND PROM OTES TUM OR-INITIATING STEM -LIKE PROLIFERATION

M . Pecoraro, V . Aranda, H . V og el, S. M u thu sw amy, A. M ills, W .M . K ey es (Centre for G enomic Reg u lation, D ifferentiation and Cancer Prog ram, B arcelona, Spain)

Induction of senescence and cell death through interference w ith telomere maintenance mechanisms in human tumorsN . Z affaroni (M ilan, Italy )

Pez coller F ou nd ation sch olarsh ip 2 0 0 8 W inner A w ardTARGETING AUTOPHAGY IN CANCER THERAPYM . Pennati (F ondaz ione IRCCS N ational Cancer Institu te, M ilan, Italy )

10.30 - 11.00 Coffee Break

11.00-12.00 “GIORGIO PRODI” LECTURE

Introduction A . F u sco (N aples, Italy )

“M en, M ice and M olecules: Present-shaping Past” M .A . Pierotti (M ilan, Italy )




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Scientifi c Programme12.00 - 12.45 AW ARD CEREM ONY

“Piero Trivella”, “Graziella Persico” and “EACR” Aw ards for the best posters

“Elena Cappannini” Aw ard for the best 2009 publication

“Pezcoller Foundation” scholarship Aw ard, G ios B ernard i, President

12.45 - 14.40 Lunch and Poster view ing

1 4 .4 0 - 1 6 .4 0 H I G H L I G H T S F R O M PH A R M A I N D U ST R Y C h airs: M . D ’Incalci (M ilan, Italy ), G . T onini (Rome, Italy )

Epiderm al grow th factor receptor and its fi rst tyrosine kinase inhibitor Gefi tinib - a journey of discoveryY . R u k az enk ov (M acclesfi eld, UK )

Developm ent of the PI3K inhibitor at Novartis Oncology M . Peters (B asel, Sw itz erland)

Focusing on new targets for the treatm ent of cancer: PF-3758309, a sm all-m olecule, potent inhibitor of p21activated kinase (PAK)J .D . G allo (M ilan, Italy )

Biom arkers and personalized healthcare in angiogenesis: unravel the tangle S. Sch erer (S. F rancisco, USA)

Pursuing answ ers on m ultiple fronts - Am gen Oncology Developm entT . L illie (Ux b ridg e, UK )

Pem etrexed: a nice story to tell F . R u sso (Sesto F iorentino, Italy )

16.40 - 17.00 Coffee break


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Scientifi c Programme1 7 .0 0 - 1 9 .0 0 D E V E L O PM E N T O F IN N O V A T IV E T H E R A PE U T IC S (Joint M eeting SIC - A IO M ) C h airs: A . B u d illon (N aples, Italy ), P. M arch etti (Rome, Italy )

Tow ards personalized target therapies in colorectal cancer: - The genetic basis of response and resistance F . D i N icolantonio (T u rin, Italy )

- Challenges for patient selection F . C iard iello (N aples, Italy ) IM IDs and bisphosphonates affecting angiogenesis microenvironment and synergizing w ith chemo in patients w ith multiple myeloma A . V acca (B ari, Italy )

The search for new therapeutic targets in sarcomas M . A glietta (T u rin, Italy )

Tumor and leukemia microenvironment: from biology to clinical target M . A nd reeff (H ou ston, USA)

1 9 .0 0 SI C G eneral A ssemb ly

2 0 .3 0 Social D inner at O p en C olonna - Palaz z o d elle E sp osiz ioni




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T h u rsd ay , O ctob er 7

0 9 .0 0 -1 2 .3 0 M I C R O E N V I R O N M E N T A N D T U M O R PR O G R E SSI O N C h airs: A . A lb ini (M ilan, Italy ), V . B ronte (Padu a, Italy )

Cell and matricellular accomplices for tumor development M .P. C olomb o (M ilan, Italy )

O11 M ET UPREGULATION BY IONIZING RADIATION FOSTERS CANCER INVASIVE GROW TH AND RADIORESISTANCE

F . D e B acco (Institu te for Cancer Research and T reatment, Candiolo, T u rin, Italy ), E . Casanov a, P. L u rag hi, G . Reato, B . V iola, T . Perera, P.M . Comog lio, C. B occaccio

O12 L-ARGININE DEPLETION IN THE TUM OR M ICROENVIRONM ENT PROM OTES M AM M ARY TUM ORIGENESIS

S. Astig iano, M . M orini, A. D e L erma B arb aro, P. D amonte, D . N oonan, V . B ronte, O . B arb ieri (Istitu to N az ionale per la Ricerca su l Cancro, G enoa, Italy )

Synaptic proteins tackle angiogenesis F . B u ssolino (T u rin, Italy )


Epithelial plasticity and metastasis S. Piccolo (Padu a, Italy )

O13 HUM AN M YELOID-DERIVED SUPPRESSOR CELLS: INDUCTION IN VITRO W ITH GROW TH FACTORS AND ANALYSIS OF M OLECULAR M ECHANISM S OF IM M UNOSUPPRESSION

S. Solito (Univ ersity of Padu a, Italy ), E . F alisi, L . Pinton, S. F rancescato, G . B asso, P. Z anov ello, V . B ronte, S. M andru z z ato


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Scientifi c ProgrammeO14 M OLECULAR M ECHANISM S CONTROLLING THE EXPRESSION OF NKG2D AND DNAM -1 LIGANDS ON DRUG-INDUCED SENESCENT M M CELLS: ROLE OF ROS AND DNA DAM AGE RESPONSE

M . Iannitto (“ Sapienz a” Univ ersity, Istitu to Pasteu r F ondaz ione Cenci B olog netti, Rome, Italy ), A. Soriani, M . Cippitelli, C. F ionda, G . M alg arini, M .R. Ricciardi, M .T . Petru cci, R. G u arini, R. F oà , A. Santoni

Regulation of Hedgehog/Gli function in neural stem/progenitor and medulloblastoma cellsA . G u lino (Rome, Italy )

12.30-13.00 CLOSING LECTURE

Regulation of self-renew al in cancer stem cells P.G . Pelicci (M ilan, Italy )

13.00 - 13.15 “ISTITUTO REGINA ELENA” AW ARD FOR THE BEST ORAL SELECTED PRESENTATION

13.15 - 13.30 CLOSING REM ARKS

scientiﬁ c programme - aim group...causes and consequences of microrna dysregulation in cancer c...

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