section 3 wound healing. 1. definition: refers to the body ’ s replacement of destroyed tissue by...
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Section 3 Wound healing
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1. Definition: Refers to the body’s replacement
of destroyed tissue by living tissue
2. Stages in healing of wound
(1) Escape of blood and exudates
(2) Acute inflammation
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(3) Contraction of the wound. The causes of contraction are not known but possible mechanisms are:
①① Shrinkage of scab in superficial woundsShrinkage of scab in superficial wounds
②② Contraction properties of granulation Contraction properties of granulation tissue attributable to contraction of tissue attributable to contraction of myofibroblasts or tissue re-modeling. myofibroblasts or tissue re-modeling.
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(4) Proliferation and migration of fibroblasts and endothelial cells.
(5) Progressive increase in mature collagen fibres during the second week forming a scar.
(6) Loss vascularity and shrinkage of the scar.
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3. Type of wound healing
(1) Healing by fist intention
A clean wound with a minimum of space between the margins.
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healing by first intention
( 参照武忠弼 病理学, 1998 修改 )
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(2) Healing by second intention
Healing by second intention differs from healing by first intention in:
① Greater tissue loss ② More inflammatory exudates and
necrotic material to remove ③ More granulation tissue therefore
a bigger scar
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healing by second intention ( 参照武忠弼 病理学, 1998 修改 )
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④ Wound contraction necessary
⑤ Slower process
⑥ Increased liability to infection
(3) Healing under scab
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4. Factors influencing wound healing
(1) Local factors adversely affecting (1) Local factors adversely affecting healinghealing
① Type of wounding agent; blunt, crushing, tearing etc.
② Infection
③ Foreign bodies in wound
④ Poor blood supply
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⑤ Excessive movement
⑥ Poor apposition of margins, e. g. large haematoma formation
⑦ Poor wound contraction due to tissue tethering
⑧ Infiltration by tumor.
⑨ Previous irradiation.
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(2) General factors adversely affecting healing
① Age
② Poor nutrition Deficiency of protein Lack of Vitamin C results in
abnormal granulation tissue and deficient collagen production
Zinc deficiency
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③ Excessive glucocorticosteroid production or administration
④ Fall in temperature
⑤ Jaundice
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(3) Factors accelerating wound healing
① Ultraviolet light.
② Administration of anabolic steroids, deoxycorticosterone acetate, cell growth factors.
③ Rise in temperature.