semiconductor solutions for the healthcare challenge...1994 2000 2010 2025 in 2025 7.3% of the...
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Semiconductor Solutions for the Healthcare Challenge
Werner Neumann
electronica Medical Forum
November 11, 2008
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Sept 2008 p.2Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.2
Healthcare – A Challenge
Source: IDF Diabetes Atlas 2006, Wikipedia, Spectaris 2008
• Health cost in Germany 2006: 148B€
• Potential to save 2.7B€ with modern medical electronics
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1994 2000 2010 2025
In 2025 7.3% of the worlds population might suffer from diabetes
Aging pyramid for Germany, Forecast for 2050
Diabetes Impaired Million people ww
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Sept 2008 p.3Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.3
STMicroelectronics’ 3 Pillars in Healthcare
Mass Market ApplicationApproach
• Products ready now
• Development Tools
• Short Time-To-Market
Healthcare Key CTM
Partnership
Develop new dedicated
products and technologies
Government programs,Consortia,Universities
Technology,Investment into
the future
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Sept 2008 p.4Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.4
ST Healthcare Solutions
Hearing Aid, Assembly Tech.
Patient Health Records
Tele-monitoring,Home Health
Imaging
Home HealthImplantsDisposable Healthcare
MolecularDiagnostic
Driving ApplicationsEmerging Applications
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Sept 2008 p.5Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.5
ST Healthcare Solutions
Molecular Diagnostic
MolecularDiagnostic
• Medical Diagnostics – Point of Care
• Environmental Control – Air/Water
• Agro-Industrial Control – Genetically Modified Objects
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Sept 2008 p.6Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.6
ST In-Check™ Platform
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Sept 2008 p.7Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.7
ST Platform Approach To Biotech Market
Expert biologists
Big Central Lab
Automation
Hospital LabIntegration
Quantification
Miniaturization - Automation - Reliability
User friendly
Low cost
Fast
Portable
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Sept 2008 p.8Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.8
In-Check™ Platform: Main Elements
Biochip Core
Reader
Software platform
Thermal Control System
Pathogen A
Pathogen B
Pathogen C
Marker A
Marker B
Biological Content From ST partners
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Sept 2008 p.9Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.9
Core Silicon Chip
Ta/Au electrodes
Thermal Sensors - Al/Si/Cu
Fluidic Inlets - Glass
Buried Channels
Surface Channels - Dry resist
Microarray Detection Area
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Sept 2008 p.10Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.10
Concept & Application
Analysis Time: 1- 2 hours
In-Check is designed as an open platform for fast and highly automated DNA analysis.
Example Screenshot
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Sept 2008 p.11Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.11
Insulin Nanopump™ in MEMS Technology
Disposable
Healthcare
Inlet valve
Pumping chamber
Outlet valveDetector
• Small, Precise, Safe
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Sept 2008 p.12Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.12
European Imaging Project: Megaframe
• Array of diodes in Geiger mode
• One million frames per second imaging
• Count of single photons with a timing resolution of 100ps.
• A new enabler for non-invasivediagnostics with big potential:
– Optical Coherence Tomography (OCT)
– Fluorescence Lifetime Analysis (FLIM)
– Blood glucose metering
– SpO2 Blood oxygen saturation level
– http://www.megaframe.eu
OCT skin analysis video
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Sept 2008 p.13Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.13
Technologies for Implantable Devices
1200V dice
3-D MEMS dice
IGBT
MEMS
HCMOS9 LP/ULL
Low Power CMOSUltra Low Leakage
0.13um CMOS
Selected Technologies
HVG8
High Voltage Gate
0.18um CMOS
High Voltage Switch
ECG Unit(ADC)
HV H-Bridge
HV Control
Switching
High Voltage
Capacitor
Capacitor ChargerControl
CircuitMemory Techno.
Power Management
Communication
MEMS Acce-
lerometer
IPAD Device Integration / Hybrids
Implants
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Sept 2008 p.14Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.14
Solutions For Each Function
PortableHealthcare
• Glucose Meter
• Insulin Pump
• Blood Pressure
• Thermometer
• Fertility Tester
• Sensors
– MEMS accelerometer
– MEMS microphone
– MEMS technology enables implantable sensors
• Analysis
– Low Power Micro / DSP Functionality
– EEPROM Memory
– ADC, Analog Std. product and ASIC
– Power Management
– RF-ASIC/ZigBee/NFC
• Drug Delivery
– Insulin Nanopump
– MCU / Dual Core ASIC
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Sept 2008 p.15Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.15
STM32 Low Power MCU
• ST provides software routines for faster Time-to-market:
• VDE Certified Firmware for STM32 Family according IEC60335 Type B, similar to SIL-2.
• 3DES/AES Encryption Libraries
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Sept 2008 p.16Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.16
Motor Control Solutions
• Respirator
• Wheelchair
• Hospital Drug Delivery
• 8-bit: ST7FMC, 32-bit: STM32Power Electronics
• BLDC, 3ph-Induction, PMSM Motors
• Vector / Field Oriented Control
– FIR and IIR filters, PID controller
– Motor control dedicated PWM peripheral
– Dual 12-bit ADC converter, 1 MS/s with synchronization capabilities
– All libraries available now
• Examples:
– Ultra silent drive
– Voice encoding / decoding for commands
– Fast Fourier Transformation
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Sept 2008 p.17Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.17
STM32-EVALBoard, Small Packages
• Starter Kits from ST, IAR, Keil, Hitex
• Demos for USB, CAN, SD Card etc…available from www.st.com/mcu
• Hotline support
• Ultra small packages available
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Sept 2008 p.18Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.18
EEPROM
• Any Communication interface in any Density:– I2C from 1 Kb to 1 Mb
– SPI from 1 Kb to 1 Mb
– Microwire from 1 Kb to 16 Kb
• On top of standard packages (SO8, SSOP8):– MLP 2x3 up to 128 Kb
– WLCSP for the smallest high density EEPROM in the world
• ST # 1 in EEPROM
• Special Service: custom trimming of key parameter
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Sept 2008 p.19Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.19
Tele-Monitoring: ZigBee, NFC
To continuously monitor variations in:
• Temperature
• Heart rate
• Blood oxygenation
• Respiratory rate
ZigBee SN250 module
Tele-Monitoring,Home Health
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Sept 2008 p.20Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.20
Miniaturized Packages
Stack Die Through Silicon Via
WLCSPWafer Level Chip Scale Package
Bumped die
SIP System in Package
Down to 400µm pitch
µQFN
Assembly Technology
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Sept 2008 p.21Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.21
New ST Micropower Operation Amplifier for Healthcare Analog Front Ends
• Market Leader
– Over 2 Billion units of analog mixed products shipped in 2007
– 6% Market Share WW in 2007
• New Product:
– High merit factor: 5V, 60µA/890kHz
– Low Vio: 1mV max
– Very narrow dispersion of Icc and AC parameters
– Micro Packages: SC70-5, SOT23-8, MSO8-10
• Available in Q1/2009
Vdd
Vss
V
t
NEW
NEW
NEW
NEW
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Sept 2008 p.22Werner Neumann
STMicroelectronics Solutions for Healthcare November 2008 - p.22
Summary
• ST is taking care
– Long term research
– Strong partnerships with market leaders
– State of the art products
– Radical innovative technology
• Products are available now
• Demoboards and support hotline for fast development
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On-Chip Cell Sorting