serbia - italia bilateral cooperation
DESCRIPTION
Serbia - Italia Bilateral Cooperation ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF THIO-AVAROL DERIVATIVES 25th and 26th June, 2012. Beograd. Pozzuoli - Napoli. The Sponges. Dysidea avara. Dr. Salvatore De Rosa Dirigente di Ricerca National Research Council of Italy - PowerPoint PPT PresentationTRANSCRIPT
Serbia - ItaliaSerbia - Italia Bilateral CooperationBilateral Cooperation
ACETYLCHOLINESTERASE ACETYLCHOLINESTERASE INHIBITORY ACTIVITY OF INHIBITORY ACTIVITY OF
THIO-AVAROL DERIVATIVESTHIO-AVAROL DERIVATIVES
25th and 26th June, 201225th and 26th June, 2012
BeogradBeograd
Pozzuoli - NapoliPozzuoli - Napoli
The SpongesThe Sponges
Dysidea avara
Dr. Salvatore De RosaDr. Salvatore De Rosa
Dirigente di RicercaDirigente di Ricerca
National Research Council of ItalyInstitute of Biomolecular Chemistry
CNR-ICBCNR-ICB
E-mail: [email protected]
Dr. Giuseppina Tommonaro Ricercatore
National Research Council of ItalyInstitute of Biomolecular Chemistry
CNR-ICB
E-mail: [email protected]
Mr. Carmine IodiceCollaboratoreTecnico ente di Ricerca
National Research Council of ItalyInstitute of Biomolecular Chemistry
CNR-ICB
E-mail: [email protected]
Avarol is a marine sesquiterpene
hydroquinone possesing a rearanged drimane skeleton.
Avarone is the quinone form of avarol.
Avarol
Avarone
Avarol was found to have
anti-inflammatory antipsoriatic antioxidant antitumor
antiplatelet analgesic anti-HIV
activities.
Of particular interest isacetylcholinesterase inhibitory
activity of thio-avarol derivatives with a carboxylic group in the
molecule, such as
avarol-3‘-thiobenzoate avarol-3‘–thiolactateavarol-4‘–thiolactate
TLC bioautographic assay(white spot on a purple background)
1 μg
Galanthamine was used a positive control.
Galanthamine 0.01 μg
NO
HO
O
H
Dr. Pietro AmodeoDr. Pietro AmodeoI RicercatoreI Ricercatore
National Research Council of ItalyInstitute of Biomolecular Chemistry
CNR-ICBCNR-ICB
E-mail: [email protected]
Dr. Rosa Maria VitaleRicercatore
National Research Council of ItalyInstitute of Biomolecular Chemistry
CNR-ICB
E-mail: [email protected]
Binding properties of avarol and its inhibitory derivatives to the
enzymehave been characterising by
computationalapproach.
This research aims to design new avarol
derivatives which better inhibitacetylcholinesterase.
Serbia - ItaliaSerbia - Italia
INSIEME NELLA SCIENZA,INSIEME NELLA SCIENZA,
INSIEME NELLA VITAINSIEME NELLA VITA