serlift sun pharma final

®

Alex Team Rana EL.Abd

© Sun Pharmaceutical Industries Limited. All Rights Reserved. 2

Intro of Depression

CausesPathology

TypesTreatment StrategySerlift®

AGENDA


Psychiatric disorder (related to mood)

Affects behavior , thinking , emotions

( Intense feeling of sadness )

DEPRESSION


Endogenous

• Chemicals imbalance (5HT – DA – NE)

Exogenous

•Bad life events (Divorce – Child

death)

CAUSES


TYPESUnipolar

BipolarNormal + Depression• Hopelessness• Sleep / Psychomotor disturbances• Worthlessness• Suicidal tendencies• Low energy / Fatigue• Loss of interest / motivation • GIT disturbances

Depression + Mania(3) Over :• Over-active• Over-talkative• Over-energetic


TREATMENT STRATEGY

Depressive phase

Manic phase

( MAOIs )

Metabolism(Reuptake inhibitors)

Concentration Mood Stabilizers(Lithium

Salts)


REUPTAKE INHIBITORS

SNRIs SSRIsNDRIs


SSRIS

(Selective Serotonin reuptake inhibitors)Ex • Sertraline , Fluoxetine , Paroxetine

, Citalopram

MOA • (-) Reuptake of 5-HT

Uses • Depression – OCD


SSRIS

S.E • Sexual dysfunction ( Libido , Rapid ejaculation )


SNRIS Tricyclic antidepressants (TCAs)

S.E • Block other receptors

Cholinergic Adrenergic α1 Histaminic H1 (Atropine like effect) (Orthostatic Hypotension ) (Sedation)

© Sun Pharmaceutical Industries Limited. All Rights Reserved.

SNRIS

Tricyclic antidepressants (TCAs)

S.E• Cardiac arrhythmia ( NE ,

HR )

• Narrow therapeutic index

( Toxicity )


SSRIS

1st Choice

Advantages

• More tolerated• Less sedation• Safe• No CVS side effects• No Atropine like effects

Over TCAs


PRODUCT PROFILE

Trade name : Serlift®

Generic name : Sertraline HCL

Concentration : 100 mg

Route of administration : Oral

Dosage form : Film coated tablets ( 10 Scored Tab )

Dose : 50mg/day ( may increases ) .. Max. 200 mg/day

Administration : With or without food


Precautions : Dose adjustment in hepatic/renal insufficiency

Interactions : Warfarin – IV Diazepam – TCAs

Side effects : Nausea – Diarrhea – Loose stool – Dyspepsia

SGOT & SGPT – Weight loss – Delayed ejaculation Over dose : Gastric lavage

Activated Charcoal

Oxygenation & ventilation

Price : 40 L.E

PRODUCT PROFILE

FDA approval (Feb 2007)

Published online January 29, 2009 DOI:10.1016/S0140-6736(09)60046-5Lancet

SSRIs Meta analysis in review



A multiple-treatments meta-analysis

Comparison between 12 new-generation

antidepressants on major depression.

Aim




• 117 randomised trials

• 25,928 participants from 1991 up to Nov 30, 2007 .

• Treatment of unipolar major depression in adults using :

Bupropion, Citalopram, Duloxetine, Escitalopram, Fluoxetine,

Fluvoxamine,Milnacipran, Mirtazapine, Paroxetine, Reboxetine,

Sertraline, and Venlafaxine.

MethodologySSRIs Meta analysis in review



• Clinically important differences for both efficacy and acceptability in favour of Escitalopram and Sertraline.

• Sertraline might be the best choice.

• The most favourable balance between benefit acceptability, and acquisition cost.

Findings



Neuro/Psychiatrists

Urologists

Dermatologists GPs

TARGET AUDIENCES

Drug name

Concn Company Tablets’ no.

price

Lustral®

50 mg Pfizer 10 40 L.E

Moodapex®

50 mg Apex 10 18 L.E

Serpass®

100 mg

Global Napi

10 32 L.E

Seserine®

50 mg Adwia 10 18 L.E

COMPETITORS

SERLIFT® MESSAGE

1st Sertraline 100mg introduced in Egypt

FDA approved

Best choice in depression treatment because of :

balance between benefit acceptability, and acquisition cost.

• US National Center for Biotechnology Information (NCBI)

http://www.ncbi.nlm.nih.gov

• North East Valley Division of General Practice Ltd.http://www.nevdgp.org.au

• Journal of Perinatologyhttp://www.nature.com/jp/index.html

•Rx List http://www.rxlist.com/script/main/hp.asp

• Medscapehttp://emedicine.medscape.com

• Pubmedhttp://www.ncbi.nlm.nih.gov/pubmed

REFERENCES

http://www.ncbi.nlm.nih.gov/

http://www.ncbi.nlm.nih.gov/

http://www.nevdgp.org.au/

http://www.nature.com/jp/index.html



http://emedicine.medscape.com/

http://www.ncbi.nlm.nih.gov/pubmed




Thank YouRana El.AbdTel : +91 22 6645 5645, Ext 000Tel Direct : +91 22 66455645Mobile : [email protected]

Thank You! For more information please contact:

© 2010 Sun Pharmaceutical Industries Limited., All Rights Reserved.“SUN Pharma”, The Sun Pharmaceutical Industries Logo are trademarks of Sun Pharmaceutical Industries Limited.

This material was used during an oral presentation; it is not a complete record of the discussion. This work may not be used, sold, transferred, adapted, abridged, copied or reproduced in whole on or in part in any manner or form or in any media without the prior written consent. All product names and company names and logos mentioned herein are the trademarks or registered trademarks of their respective owners.

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