sharing and open knowledge and the future of scientific research by hiroaki kitano
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Sharing and Open Knowledge and the Future of Scientific
ResearchHiroaki Kitano
The Systems Biology Institute
Sony Computer Science Laboratories, Inc.
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EGF Receptor Cascade
Oda, et al. Molecular Systems Biology, 2005
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Architectural Feature
Kitano, Nature Reviews Genetics, Nov. 2004
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Copyright ©2007 by the National Academy of Sciences
Kim, Pan-Jun et al. (2007) Proc. Natl. Acad. Sci. USA 104, 13638-13642
Fig. 1. Characteristics of essential and nonessential metabolites in E. coli metabolism
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Ma et al, Molecular Systems Biology, Sept 2007
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Bow-Tie Architecture of Wikipedia links
Capocci, et al., Phys Rev. E 74, 036116, 2006
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EGF Receptor Cascade
Oda, et al. Molecular Systems Biology, 2005
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Oda, et al. Molecular Systems Biology, 2005
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TLR Bow-Tie Structure
Oda and Kitano, Molecular Systems Biology, April 2006
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低下する製薬産業の生産性
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Copyright ©2003 by the National Academy of Sciences
Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 7977-7982
Multicomponent therapeutics that prevent proliferation of fluconazole-resistant C. albicans
CombinatoRX (CRXX: NASDAQ) cHTS
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Copyright ©2003 by the National Academy of Sciences
Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 7977-7982
Chlorpromazine, an antipsychotic agent, and pentamidine, an antiprotozoal agent, together selectively prevent tumor cell growth in vitro and in vivo
Phase 1/2A Stage
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Copyright ©2003 by the National Academy of Sciences
Borisy, Alexis A. et al. (2003) Proc. Natl. Acad. Sci. USA 100, 7977-7982
Chlorpromazine, an antipsychotic agent, and pentamidine, an antiprotozoal agent, together selectively prevent tumor cell growth in vitro and in vivo
Phase 1/2A Stage
Efficacy
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朝鮮人参の成分分析
Wang, M. et al., Phytother Res. 2005 Mar;19(3):173-82
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Open Pharma• Combination of Generic compounds to
generate highly effective drugs• Equivalent efficacy by partial replacement
of compounds• Value lies in “Combination” rather than
compound itself.
• Toward open source pharmaceutical industry
The Rule of the Game Will Change
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“PAYAO”Web 2.0 Community Tagging System
to SBML models
Okinawa Institute of Science and TechnologyThe Systems Biology Institute
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“PAYAO”
• an artificial floating raft where fish congregate
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Payao: Web2.0 Community-Based Biological Knowledge Accumulation System
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SBML Models Tagging System
*CellDesigner files
PAYAOSBML Models Tagging System
Manage Models,
Users,Groups
SBML files
Register a model
Store models, Tags, Comments
Login Users
VisitorsModel OwnerAdd Comments
Add/Edit Tags
to the model
View Models withCellDesigner notation
Group A
Group B
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Model View
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Model View with Tag Marks
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Tag
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View a Tag
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Add Comments to a Tag
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View Comments to a Tag
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PubMed ID Link
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Healthcare & Wellness ConciergeGenome Diagnosis(23 and me)
Wellness(India, etc)
Personalized & Preventive medicine
How to integratemedicine and wellness?
Herbal medicine, meditation, etc.
Novel Drug Design and Integrated Healthcare Support
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Summary
• Networks are complex but has sort of “design principles”
• Long tail drug need to be pursued to create more effective drugs
• Open Pharma may open up a whole new paradigm of drug design, distribution, and services.
• Open infrastructure is the key for success