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SHARON BIOMIX BLENDS
Laboratorie
Laboratories
With Over 30 years’ experience, Sharon
Laboratories specializes in designing and
manufacturing effective preservative solutions
for the global personal care market. Sharon
Laboratories developed a range of broad
spectrum products containing Biosecur® Lab
unique organic citrus extracts, designated for
the preservation of personal care products.
The well-established know-how in cosmetic
preservation gained by Sharon Laboratories
during 30 years of serving the personal
care industry was combined with the
Biosecur® technology. This cooperation
yielded a new family of products that can
meet the worldwide growing demands for
milder and greener cosmetic formulations
without compromising on the performance.
SHARON BIOMIX blends are characterized with
broad spectrum efficacy, good solubility in water
and commonly used solvents, good tolerance
to elevated temperatures and preformance in a
wide pH range. The recommended use level of
these products is less than 1%. These blends
are ideal for Leave-on and Rinse-off products.
SHARON LABORATORIES
SHARON BIOMIX BLENDS
PRESERVATIVE FREE BLENDS
SHARON BIOMIX FREE
INCI of Sharon Biomix Free I :
Phenethyl Alcohol, Glycerine, Citrus Reticulata Fruit Extract, Citrus Aurantium Amara Fruit
Extract, Citrus Sinensis Peel Extract, Ascorbic acid, Citric acid, Lactic acid, Aqua
INCI of Sharon Biomix Free II :
Phenylpropanol, Glycerine, Citrus Reticulata Fruit Extract, Citrus Aurantium Amara Fruit
Extract, Citrus Sinensis Peel Extract, Ascorbic acid, Citric acid, Lactic acid, Aqu a
For those seeking antimicrobial protection to cosmetic products without using common
preservatives, a combination of Biosecur citrus extracts with certain fragrance ingredients such
as Phenethyl Alcohol or Phenylpropanol can be a good broad spectrum solution.
MINIMUM INHIBITION CONCENTRATION (MIC) FOR SHARON BIOMIX FREE
Microorganism + ATCC NumberSHARON BIOMIX FREE I
(Phenethyl Alcohol)SHARON BIOMIX FREE II
(Phenylpropanol)
Staphylococcus aureus 6538 156 125
Escherichia coli 8739 1250 500
Pseudomonas aeruginosa 9027 2500 1250
Bacillus cereus 11778 312 250
Staphylococcus epidermidis 14990 156 62
Aspergillus niger 16404 2000 1000
Candida albicans 10231 625 500
NATURAL PRESERVATIVES BLENDS
SHARON BIOMIX PURE
INCI of Sharon Biomix Pure I :
Natural Benzyl Alcohol, Glycerine, Citrus Reticulata Fruit Extract, Citrus Aurantium Amara Fruit
Extract, Citrus Sinensis Peel Extract, Tocopherol, Ascorbic acid, Citric acid, Lactic acid, Aqua
INCI of Sharon Biomix Pure II :
Natural Phenethyl Alcohol, Glycerine, Citrus Reticulata Fruit Extract, Citrus Aurantium Amara
Fruit Extract, Citrus Sinensis Peel Extract, Ascorbic acid, Citric acid, Lactic acid, Aqua
Sharon Biomix Pure is a blend of citrus extracts in natural Benzyl Alcohol or natural Phenethyl
Alcohol. These preservatives blends are designated to protect natural personal care products.
The natural Benzyl Alcohol is protected from oxidation by Vitamin E of natural source.
Biosecur C160S
Biosecur C160S contains potent citrus extracts with Glycerin of natural source that provides
excellent antimicrobial preservative efficacy against Gram negative and Gram positive Bacteria.
This certified Organic preservative is active at low concentrations, effective over a wide range
of pH and can withstand high temperatures. All this makes C160S suitable for both rinse-off
and leave-on products.
Challenge tests performed by Sharon Labs with these products
Method applied
The method applied is based on the USP 30 guidelines for antimicrobial effectiveness testing.
The microorganisms used for the test are listed in the table below. Five samples of the product
are inoculated with 1 microorganism each. A four week follow up is performed.
Criteria used for results interpretation
The criteria applied are USP 30 criteria for Category 1 Products :
At least 1 log reduction in the bacterial counts by the 7th day.
At least 3 logs reduction in the bacterial counts by the 14th day.
No increase in bacterial counts during the 14 – 28 days period.
No increase in the yeast and mold counts at 7, 14, and 28 days (compared to the initial count)
E. coliATCC 8739
S. aureusATCC 6538
P. aeruginosaATCC 9027
C. albicansATCC 10231
A. nigerATCC 16404
Inoculum 5.9*105 5.1*105 6.6*105 2.8*105 1.9*105
7 days 20 <10 <10 <10 1.7* 103
14 days <10 <10 <10 <10 1* 103
21 days <10 <10 <10 <10 <10
28 days <10 <10 <10 <10 <10
Sample tested : Face cream. pH 6.7
Preservation : 0.8% SHARON BIOMIX CLEAR
E. coliATCC 8739
S. aureusATCC 6538
P. aeruginosaATCC 9027
C. albicansATCC 10231
A. nigerATCC 16404
Inoculum 9.5*105 4.9*105 5.6*105 1.6*105 2*105
7 days 2.1*103 <10 <10 1.9*103 2* 102
14 days <10 <10 <10 <10 <10
21 days <10 <10 <10 <10 <10
28 days <10 <10 <10 <10 <10
Sample tested : Face cream. pH 6.7
Preservation : 0.8% SHARON BIOMIX ECO
E. coliATCC 8739
S. aureusATCC 6538
P. aeruginosaATCC 9027
C. albicansATCC 10231
A. nigerATCC 16404
Inoculum 8.0*105 1.0*106 5.5*105 2.5*105 2.9*105
7 days 1.5* 103 <10 <10 2.0*102 1.5* 104
14 days <10 <10 <10 <10 <10
21 days <10 <10 <10 <10 <10
28 days <10 <10 <10 <10 <10
Sample tested : Face cream. pH 6.7
Preservation : 0.8% SHARON BIOMIX FREE I
E. coliATCC 8739
S. aureusATCC 6538
P. aeruginosaATCC 9027
C. albicansATCC 10231
A. nigerATCC 16404
Inoculum 2.7*105 7.8*105 7.6*105 1.6*105 2.0*105
7 days <10 <10 <10 <10 <10
14 days <10 <10 <10 <10 <10
21 days <10 <10 <10 <10 <10
28 days <10 <10 <10 <10 <10
Sample tested : Face cream. pH 6.9
Preservation : 0.8% SHARON BIOMIX FREE II
Furocoumarins analysisThe natural extract blend was analyzed and no presence of Furocoumarins was detected by
HPLC analysis. Based on the detection limit we can safely conclude that all SHARON BIOMIX
products have a Furocoumarins level of under 1ppm.
PhototoxicityThe phototoxicity potential of Biosecur C160S was tested in Vitro according to OECD guidelines
432. The test results indicate that the product is not phototoxic.
Primary skin irritation testsThe primary skin irritation potential of the natural extract blend was evaluated using human
volunteers.
Solutions, containing 2000 ppm, 5000 ppm, and 10000 ppm extract in saline were applied
under occlusive conditions for 48 hours on the back skin of the volunteers.
An examination of the skin was performed by a dermatologist 15 minutes and 24 hours after
product removal.
The average irritation scores are given hereafter :
As all irritation scores were lower than 0.5, the three solutions can be considered when
applying the Draize criteria as non irritant.
Further information regarding the test procedure is available upon request.
DETERMINATION OF SENSITIZING PROPERTIESThe sensitizing properties were evaluated using Draize repeated insult patch test in 50 human
volunteers.
The tested solution did not induce in the 10th application (challenge phase) a contact dermal
irritation and/or sensitization in any of the tested subjects.
Extract concentrationIrritation score
15 minutes after removalIrritation score
24 hours after removal
2 000 ppm 0.05 0.05
5 000 ppm 0.2 0.15
10 000 ppm 0.3 0.2
PRESERVATIVES BLENDS
SHARON BIOMIX CLEARINCI : Phenoxyethanol, Glycerine, Citrus Reticulata Fruit Extract, Citrus Aurantium Amara Fruit
Extract, Citrus Sinensis Peel Extract, Ascorbic acid, Citric acid, Lactic acid, Aqua
Phenoxyethanol is a popular preservative in leave-on and Rinse-off products, well known for
its low sensitizing qualities. When combining Biosecur citrus extracts with Phenoxyethanol
the blend yields broad spectrum protection to cosmetic formulations, with efficacy against
bacteria, yeast and mold.
MINIMUM INHIBITION CONCENTRATION (MIC) FOR SHARON BIOMIX CLEAR
Microorganism + ATCC Number SHARON BIOMIX CLEAR
Staphylococcus aureus 6538 156
Escherichia coli 8739 1000
Pseudomonas aeruginosa 9027 1500
Bacillus cereus 11778 156
Staphylococcus epidermidis 14990 62
Aspergillus niger 16404 1500
Candida albicans 10231 375
BLENDS THAT FOLLOW
GREEN ORGANIZATIONSSHARON BIOMIX ECOINCI : Benzyl Alcohol, Glycerine, Citrus Reticulata Fruit Extract, Citrus Aurantium Amara Fruit
Extract, Citrus Sinensis Peel Extract, Tocopherol, Citric acid, Lactic acid, Ascorbic acid, Aqua
A combination of citrus extracts with Benzyl Alcohol can be a good solution for those
formulators seeking for green broad spectrum preservative blends. For this special type of
naturally oriented cosmetic products Sharon Biomix Eco was developed. The Citrus extracts
included in this product have organic certification while Benzyl alcohol enjoys high
acceptability in green cosmetic products.
MINIMUM INHIBITION CONCENTRATION (MIC) FOR SHARON BIOMIX ECO
Microorganism + ATCC Number SHARON BIOMIX ECO
Staphylococcus aureus 6538 156
Escherichia coli 8739 312
Pseudomonas aeruginosa 9027 1250
Bacillus cereus 11778 156
Staphylococcus epidermidis 14990 78
Aspergillus niger 16404 800
Candida albicans 10231 187
SHARON LABORATORIES REPRESENTATIVES
JLLC “AmphoChem”Pobeditelej ave. 5, of. 307220004, MinskTel: + 375 17 306 46 05Email: [email protected]
LasersonB.P. 57 - Parc d’Activités Sudessor6, Avenue des Grenots91151 Etampes Cedex, France Tel: +33 1 69 16 82 00 Email: [email protected]
SLI Chemicals GmbHInsterburger Strasse 7D-60487 Frankfurt am Main, GermanyTel: +49 69 747 4280Email: [email protected]
Cellco Chemicals Ltd.19600 Mandra - Attica, GreeceTel: +30 2105 555 495Email: [email protected]
Eigenmann & Veronelli S.p.Via Della Mosa, 6Rho 20017, ItalyTel: +39 02 9353 9343Email: [email protected]
Donauchem Polska ul. Walbrzyska 11/40302-739 Warsaw, PolandCosmetics and Household ChemistryTel: +48 22 549 9211Email: [email protected]
Russo Chemie109542, Moscow Ryazanskiy prospekt, h.86/1, bld.2, RussiaTel: +7 495 231 22 17Email: [email protected]
Comercial Quimica MassoC/VILADOMAT, 321, 5º, SpainTel: +34 93 495 2500Email: [email protected]/fcr
Arisan Kimya Sanayi ve Ticaret ASBarbaros bulvari. Edep sok. No:23 34775 Y. Dudullu-Umraniye, Istanbul, TurkeyTel: +90 216 526 4600 pbxEmail: [email protected]
Azelis UK Life Sciences Ltd.Foxholes Business Park John Tate Road, Hertford Herts. SG13 7YH, UKTel: +44 1992 825 555 Email: [email protected]
Nuplex Specialties Building I, Suite 15, 22 Powers Road Seven Hills, NSW 2147, AustraliaTel: +61 2 9839 4000 Email: [email protected] www.apsg.com.au/health.html
Pioma Chemicals101-103, Shyam Kamal ‘D’ Agarwal Market, Vile Parle-East Mumbai-400 057, IndiaTel: +91 22 2619 2662Email: [email protected]
Maruzen Chemicals Co. Ltd. 4-7, 2-Chome, Doshomachi, Chuo-Ku Osaka, 541-0045, Japan Tel: +81 6 6206 5415 Email: [email protected]
Chang Hyup Trading Co. Ltd.#1009 Life Officetel, 61-3, Youido, Youngdungpo, Seoul, KoreaTel: +82 2 761 7901Email: [email protected]
Accord International, Inc.Accord House, 605 Cordillera St. Mandaluyong City 1550, PhilippinesTel: +63 2 531 4881 to 86Email: [email protected]
Nardev Chemie Pte. Ltd.61 Kaki Bukit Ave 1 #05-01 Shun Li Industrial Park Singapore, 417943 Tel: +65 6743 7480 Email: [email protected]
Propagate Trading Co. Ltd.Ming young building, 3F-3 No 316Chung HO RD, Chung HO cityTaipei HSIN, TaiwanEmail: [email protected]
Namsiang Co. Ltd.19 Sukhumvit 70, Bangna, Bangna Bangkok 10260, ThailandTel: +66 2 361 7301 to 4Email: [email protected]
Ferguson Chemical InnovationBrampton, 235 Advance Road Ontario, L6T 4J2, CanadaTel: +905-453-7131 Email: [email protected]
Acme-Hardesty Company450 Sentry Parkway, Suite 104Blue Bell, PA 19422, USATel: +1 215 591 3610Email: [email protected]
Coast Southwest, Inc.505 South Melrose StreetPlacentia, California, USATel: +1 800 621-0500, Email: [email protected]
M. CassabFondo de la Legua, 111, 2do. Piso, of.B.San Isidro, 1607, Argentina Tel: +541148363310 Email: [email protected]
Sharon Labs Brasil Ltda.A subsidiary of Sharon Laboratories Ltd.Rua Eduardo Borsari, 1679Distrito Industrial Domingos Giomi13.347-320 Indaiatuba – São Paulo, BrasilTel: +55 19 3936 6222Email: [email protected]
Brenntag Chile Ltd.Camino Lo Sierra 02966San Bernardo, Santiago de Chile, ChileTel: +56 2 440 2400Email: [email protected]
Merquimia Colombia S.A.Terminal Terrestre de Carga Oikos, Modulo 5 Bodega 13-14,Autopista Medellin Km 3,5Tel: +578415088Email: [email protected]
Brenntag Caribe S.A.Ave. Isabel Aguiar No. 209,Zona Industrial HerreraSanto Domingo, Rep. DominicanaTel: +8095318060Email: [email protected]
Brenntag Guatemala23 avenida 40 -19 zona 12,Guatemala Ciudad,AP 010012, GuatemalaTel: +50224237777Email: [email protected]
Brenntag MéxicoCalle Tecojotes L8 Mz 4Parque industrial San Martin ObizpoCuatitlan - Estado de MéxicoCP54796 MéxicoTel: +52 55 58996400Email: [email protected]
Hexa Quimica SACPasaje Ismael Castillo 145Lince Lima, PeruTel: + 511 719 8900 Email: [email protected]
Chemsources C.A. Centro Comercial Macaracuay Plaza, Nivel C-3, Caracas, Venezuela 1070Tel: +58212 2575030Email: [email protected]
Zifroni Chemicals Suppliers Ltd.4 Homa St. New Industrial Zone Rishon Le-zion 75655, IsraelTel: +972 3 961 1955 Email: [email protected]
CJP Chemicals (PTY) Ltd.32 Tiger Moth St., AerotonJohannesburg, South Africa Tel: +27 11 494 6700Email: [email protected]
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